Problem statement: Answer the MCQ question.
Query: Which drug has a 1.145\% human ether-à-go-go related gene (hERG) inhibition at a concentration of 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a.) Clc1ccc(-c2noc(/C=C/c3ccccc3)n2)cc1
b.) COC(=O)C1=C(c2cccc(C#N)c2)C[C@@H]2CC[C@H]1N2C(=O)N1CCCCC1
c.) Cc1ccccc1Sc1ncccc1[N+](=O)[O-]
d.) COc1ccc(CC(=O)N2CC3(C)CC2CC(C)(C)C3)cc1OC
e.) COc1ccc(OCC(=O)Nc2cc(NC(=O)COc3ccc(OC)cc3)cc(C(=O)O)c2)cc1
Answer: b. COC(=O)C1=C(c2cccc(C#N)c2)C[C@@H]2CC[C@H]1N2C(=O)N1CCCCC1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COC(=O)C1=C(c2cccc(C#N)c2)C[C@@H]2CC[C@H]1N2C(=O)N1CCCCC1
COC(=O)C1=C(c2cccc(C#N)c2)C[C@@H]2CC[C@H]1N2C(=O)N1CCCCC1
methyl (1R,5S)-3-(3-cyanophenyl)-8-(piperidine-1-carbonyl)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate