Problem statement: Answer the MCQ question.
Question: Which drug has a 10.546\% human ether-à-go-go related gene (hERG) inhibition at 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
a.) Cc1nn(S(=O)(=O)c2ccc(C(C)(C)C)cc2)c(C)c1S(=O)(=O)N1CCOCC1
b.) Cc1cccc2nc(-c3ccccc3)nc(N3CCC(O)(c4ccc(Cl)cc4)CC3)c12
c.) CC(CCc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1.Cl
d.) Cc1ccc(N2C(=O)CC(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3)C2=O)c(C)c1
e.) C[C@@]12C(=O)N(c3cccc(Cl)c3)C(=O)N1[C@H](c1ccc(Cl)cc1)[C@@H]1C(=O)N(C3CCCCC3)C(=O)[C@@H]12
Answer: e. C[C@@]12C(=O)N(c3cccc(Cl)c3)C(=O)N1[C@H](c1ccc(Cl)cc1)[C@@H]1C(=O)N(C3CCCCC3)C(=O)[C@@H]12
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
C[C@@]12C(=O)N(c3cccc(Cl)c3)C(=O)N1[C@H](c1ccc(Cl)cc1)[C@@H]1C(=O)N(C3CCCCC3)C(=O)[C@@H]12
C[C@@]12C(=O)N(c3cccc(Cl)c3)C(=O)N1[C@H](c1ccc(Cl)cc1)[C@@H]1C(=O)N(C3CCCCC3)C(=O)[C@@H]12
(1S,2R,7S,8R)-4-(3-chlorophenyl)-7-(4-chlorophenyl)-10-cyclohexyl-2-methyl-4,6,10-triazatricyclo[6.3.0.02,6]undecane-3,5,9,11-tetrone