Problem statement: Answer the multiple-choice question.
Question: Which drug has a -10.741\% hERG inhibition at 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a O=C(Nc1ccc(C#Cc2ccccc2)cc1)C1CC1
b COC(=O)C1=C(c2ccc(-c3ccccc3)c(F)c2)C[C@@H]2CC[C@H]1N2C(=O)NCc1cc(C)oc1C(F)(F)F
c COc1ccc(NC(=O)CN(C)CC(=O)Nc2ccccc2SC)cc1
d Cc1cc(NC(=O)CSc2nnnn2C)n(-c2ccccc2)n1
e COCCNc1cc(C)nc2c(-c3ccccc3OC)c(C)nn12
Answer: b. COC(=O)C1=C(c2ccc(-c3ccccc3)c(F)c2)C[C@@H]2CC[C@H]1N2C(=O)NCc1cc(C)oc1C(F)(F)F
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COC(=O)C1=C(c2ccc(-c3ccccc3)c(F)c2)C[C@@H]2CC[C@H]1N2C(=O)NCc1cc(C)oc1C(F)(F)F
COC(=O)C1=C(c2ccc(-c3ccccc3)c(F)c2)C[C@@H]2CC[C@H]1N2C(=O)NCc1cc(C)oc1C(F)(F)F
methyl (1R,5S)-3-(3-fluoro-4-phenylphenyl)-8-[[5-methyl-2-(trifluoromethyl)furan-3-yl]methylcarbamoyl]-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate