Problem statement: Answer the multiple-choice question.
Question: Which drug has a -3.638\% human ether-à-go-go related gene (hERG) inhibition at 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
[a] Cc1ccc([N+](=O)[O-])cc1NC(=S)NC(=O)c1ccco1
[b] C#Cc1ccc([C@@H]2C=C(C(=O)NCc3nc4ccccc4[nH]3)O[C@H](OCC)[C@H]2CCCO)cc1
[c] CC(NC(=O)COC(=O)COc1cccc2c1OC(C)(C)C2)c1ccccc1
[d] O=C(COC(=O)c1ccc(NS(=O)(=O)c2cccs2)cc1O)Nc1ccc(F)cc1
[e] Cc1ccc(S(=O)(=O)NCC2CCC(C(=O)N3CCN(C)CC3)CC2)cc1
Answer: b. C#Cc1ccc([C@@H]2C=C(C(=O)NCc3nc4ccccc4[nH]3)O[C@H](OCC)[C@H]2CCCO)cc1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
C#Cc1ccc([C@@H]2C=C(C(=O)NCc3nc4ccccc4[nH]3)O[C@H](OCC)[C@H]2CCCO)cc1
C#Cc1ccc([C@@H]2C=C(C(=O)NCc3nc4ccccc4[nH]3)O[C@H](OCC)[C@H]2CCCO)cc1
(2S,3S,4R)-N-(1H-benzimidazol-2-ylmethyl)-2-ethoxy-4-(4-ethynylphenyl)-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxamide