Problem statement: Answer the multiple choice question.
Question: Which drug exhibits a 6.271\% human ether-à-go-go related gene (hERG) inhibition at a concentration of 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
[a] O=C(COC(=O)c1cnccn1)Nc1c(Cl)cc(Cl)cc1Cl
[b] COc1ccc(C(=O)Nc2cccnc2Cl)cc1OC
[c] O=C1N=C(N2CCOCC2)S/C1=C\c1ccccc1OS(=O)(=O)c1ccccc1
[d] COc1cc(Cl)ccc1OCc1cc(C(=O)NCCCN2CCCC2=O)no1
[e] COC(=O)C1=C(C(=O)OC)[C@@H]2Nc3ccccc3[C@@]23C[C@@H](C(=O)OC)N(C(=O)c2ccco2)C3=N1
Answer: e. COC(=O)C1=C(C(=O)OC)[C@@H]2Nc3ccccc3[C@@]23C[C@@H](C(=O)OC)N(C(=O)c2ccco2)C3=N1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COC(=O)C1=C(C(=O)OC)[C@@H]2Nc3ccccc3[C@@]23C[C@@H](C(=O)OC)N(C(=O)c2ccco2)C3=N1
COC(=O)C1=C(C(=O)OC)[C@@H]2Nc3ccccc3[C@@]23C[C@@H](C(=O)OC)N(C(=O)c2ccco2)C3=N1
trimethyl (1S,9R,15S)-14-(furan-2-carbonyl)-8,12,14-triazatetracyclo[7.7.0.01,13.02,7]hexadeca-2,4,6,10,12-pentaene-10,11,15-tricarboxylate