Problem statement: Answer the MCQ question.
Question: Which compound has a -21.272\% human ether-à-go-go related gene (hERG) inhibition at 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1
b COc1cc(C(=O)COC(=O)Cc2cnc3sccn23)cc(OC)c1OC
c COc1cc2c(C(=O)N3CCN(c4cccc(Cl)c4)CC3)cn(C)c(=O)c2cc1OC
d Nc1ccc(C(=O)N2CCN(S(=O)(=O)c3ccc4c(c3)OCCO4)CC2)cc1[N+](=O)[O-]
e O=C(C1CCCC1)N(c1ccccc1)C1C=CS(=O)(=O)C1
Answer: c. COc1cc2c(C(=O)N3CCN(c4cccc(Cl)c4)CC3)cn(C)c(=O)c2cc1OC
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COc1cc2c(C(=O)N3CCN(c4cccc(Cl)c4)CC3)cn(C)c(=O)c2cc1OC
COc1cc2c(C(=O)N3CCN(c4cccc(Cl)c4)CC3)cn(C)c(=O)c2cc1OC
4-[4-(3-chlorophenyl)piperazine-1-carbonyl]-6,7-dimethoxy-2-methylisoquinolin-1-one