Task: Please answer the multiple choice question.
Question: Which molecule has the highest Caco-2 cell effective permeability?
Constraint: Even if you are not sure, you must pick either a, b, c, d, or e without using any other words.
Options:
a) COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12
b) CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1
c) COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1
d) COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC
e) COCCNC(=O)[C@H](NC(=O)[C@](O)(Cc1ccccc1)CN(Cc1ccc(Br)cc1)NC(=O)[C@H](CC(=O)OC)C(C)(C)C)C(C)C
Answer: e
Task: Please answer the multiple choice question.
Question: Which molecule has the highest {permeability__names__noun}?
Constraint: Even if you are {#uncertain|not sure!}, you must pick either {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%permeability%}
Answer: {%multiple_choice_result}
methyl(3R)-3-[[[(2S)-2-benzyl-2-hydroxy-3-[[(2R)-1-(2-methoxyethylamino)-3-methyl-1-oxobutan-2-yl]amino]-3-oxopropyl]-[(4-bromophenyl)methyl]amino]carbamoyl]-4,4-dimethylpentanoate