User: I want to design a drug with a particular solubility in aqueous pH 7.4 buffer at 20 deg C.
Assistant: I would need to know the solubility in aqueous pH 7.4 buffer at 20 deg C of the drug you want to design.
User: The solubility in aqueous pH 7.4 buffer at 20 deg C should be 4.350 log(microM).
Assistant: I advise the drug with the SMILES COc1cnc(Cl)c(Nc2ncnc3cc(OCCN4CCN(C(C)=O)CC4)cc(OC(C)C)c23)n1.
User: I want to {#design|discover|find|identify|!} a {#compound|drug|chemical|molecule!} with a particular {target__names__noun}.
Assistant: {#Cool, |Awesome, |Great, |That sounds interesting, |!}I would need to know the {target__names__noun} of the {#compound|drug|chemical|molecule!} you want to design.
User: The {target__names__noun} should be {target#} {target__units}.
Assistant: I {#recommend|suggest|propose|advise|!} the {#compound|drug|chemical|molecule!} with the {SMILES__description} {SMILES#}.
COc1cnc(Cl)c(Nc2ncnc3cc(OCCN4CCN(C(C)=O)CC4)cc(OC(C)C)c23)n1
COc1cnc(Cl)c(Nc2ncnc3cc(OCCN4CCN(CC4)C(=O)C)cc(OC(C)C)c23)n1
1-[4-[2-[4-[(3-chloro-6-methoxypyrazin-2-yl)amino]-5-propan-2-yloxyquinazolin-7-yl]oxyethyl]piperazin-1-yl]ethanone