Question: help me identify which of the options below have a aqueous solubility in pH 7.4 buffer at 20 deg C of 5.200 log(microM).
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options: a COc1ncc(-c2cccc3c2C[C@H](NC(=O)c2ccc(COCC(F)(F)F)nc2)CO3)cn1
b N#CC1(NC(=O)[C@@H]2CCCC[C@H]2C(=O)N2CCc3oc4ccccc4c3C2)CC1
c CN1CCN(CCOc2n[nH]c3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)CC1
d O=C(CN1C(=O)C(NC(=O)c2cc3cc(Cl)sc3[nH]2)Cc2ccccc21)NC(CO)CO
e COc1ccc(-c2csc(NC(=O)c3c(C)noc3C)n2)cc1OC
Answer: a
{#Question:|Q:!} help me identify which of the options below have a {target__names__noun} of {target#} {target__units}.
Constraint: You must select none, one or more options from {%multiple_choice_enum%3-5%aA1} without using any {#other|additional!} words.
Options: {SMILES%target%}
Answer: {%multiple_choice_result}
COc1ncc(-c2cccc3c2C[C@H](NC(=O)c2ccc(COCC(F)(F)F)nc2)CO3)cn1
COc1ncc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(COCC(F)(F)F)nc4
N-[(3S)-5-(2-methoxypyrimidin-5-yl)-3,4-dihydro-2H-chromen-3-yl]-6-(2,2,2-trifluoroethoxymethyl)pyridine-3-carboxamide