Task: Please answer the multiple choice question.
Question: Which molecules are not penetrating the blood brain barrier to reach the brain?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
(a) O=C1CN=C(C2=CCCCC2)c2cc(Cl)ccc2N1
(b) CN1C(=O)CN=C(C2=CCCCC2)c2cc([N+](=O)[O-])ccc21
(c) CC[C@@]1(O)C[C@H](OC2CC(N(C)C)C(OC3CC(O)C(OC4CCC(=O)C(C)O4)C(C)O3)C(C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC
(d) CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)/C(=N/OCOCCOC)[C@H](C)[C@@H](O)[C@]1(C)O
(e) CCOC1c2ccccc2C(=O)N(C)c2ccccc21
Answer: c, d
Task: Please answer the multiple choice question.
Question: Which molecules are {penetrate_BBB#not &NULL}{penetrate_BBB__names__adjective}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%penetrate_BBB%}
Answer: {%multiple_choice_result}