Task: Please answer the multiple choice question.
Question: Which molecules are not penetrating the blood brain barrier to reach the brain?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
(a) CC1(C)S[C@@H]2[C@H](NC(=O)C(C(=O)Oc3ccccc3)c3ccccc3)C(=O)N2[C@H]1C(=O)O
(b) O=C(O)/C=C\C(=O)O.c1csc(Cc2ccccc2OCC2CNCCO2)c1
(c) Cc1cn([C@H]2C=C[C@@H](CO)O2)c(=O)[nH]c1=O
(d) Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2
(e) CNCCC=C1c2ccccc2C2CC2c2ccccc21
Answer: a
Task: Please answer the multiple choice question.
Question: Which molecules are {penetrate_BBB#not &NULL}{penetrate_BBB__names__adjective}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%penetrate_BBB%}
Answer: {%multiple_choice_result}