User: I want to come up with a SMILES.
Assistant: This sounds very exciting. Should I consider any constraints for the generation?
User: Yes, please. The molecule should not be active against HIV.
Assistant: Ok, this SMILES is not active against HIV: COc1cc2c(oc(=O)c3cc4ccoc4c(OC)c32)c2cccc(O)c12
User: I want to {#come up with|create|generate!} a {#molecule |!}{SMILES__description}.
Assistant: {#This sounds very exciting. |This sounds very interesting. !}Should I consider any {#constraints|specific points!} for the {#generation|creation!}?
User: Yes, please. The molecule should {activity_HIV#not &NULL}be {activity_HIV__names__adjective}.
Assistant: {#Ok|Got it!},{# here you go,|!} this {SMILES__description} is {activity_HIV#not &NULL}{activity_HIV__names__adjective}: {SMILES#}
18-hydroxy-3,20-dimethoxy-5,12-dioxapentacyclo[11.8.0.02,10.04,8.014,19]henicosa-1(21),2(10),3,6,8,13,15,17,19-nonaen-11-one