The molecule with the SMILES O=C(O)COCCN1CCN([C@H](c2ccccc2)c2ccc(Cl)cc2)CC1 is not a CYP P450 3A4 substrate.
The molecule with the {SMILES__description} {#representation of |!}{SMILES#} is {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}.