User: Is the molecule with the SMILES COC(=O)Nc1nc2cc(C(=O)c3ccccc3)ccc2[nH]1 metabolized by CYP P450 3A4?
Assistant: No, it is not a substrate for CYP3A4.
User: Is the molecule with the {SMILES__description} {SMILES#} {CYP3A4_Substrate__names__verb}?
Assistant: {CYP3A4_Substrate#No&Yes}, it is {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}.