User: I want to generate a SMILES.
Assistant: This sounds very interesting. Should I consider any constraints for the creation?
User: Yes, please. The molecule should not be metabolized by CYP P450 3A4.
Assistant: Ok, here you go, this SMILES is not metabolized by CYP P450 3A4: O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl
User: I want to {#come up with|create|generate!} a {#molecule |!}{SMILES__description}.
Assistant: {#This sounds very exciting. |This sounds very interesting. !}Should I consider any {#constraints|specific points!} for the {#generation|creation!}?
User: Yes, please. The molecule should {CYP3A4_Substrate#not &NULL}be {CYP3A4_Substrate__names__verb}.
Assistant: {#Ok|Got it!},{# here you go,|!} this {SMILES__description} is {CYP3A4_Substrate#not &NULL}{CYP3A4_Substrate__names__verb}: {SMILES#}