Task: Please answer the multiple choice question.
Question: Which molecules are not a CYP P450 3A4 substrate?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a. C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1
b. CCn1cc(C(=O)O)c(=O)c2ccc(C)nc21
c. CCOCn1c(Cc2ccccc2)c(C(C)C)c(=O)[nH]c1=O
d. N#Cc1ccc(C(c2ccc(C#N)cc2)n2cncn2)cc1
e. COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2CCN(C(c3ccccc3)c3ccccc3)CC2)[C@H]1c1cccc([N+](=O)[O-])c1
Answer: a, b
Task: Please answer the multiple choice question.
Question: Which molecules are {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%CYP3A4_Substrate%}
Answer: {%multiple_choice_result}