User: Can you create the SMILES of a molecule that is a not CYP P450 3A4 substrate?
Assistant: Of course, here you go: CCN(CC)CCS(=O)(=O)[C@@H]1CCN2C(=O)c3coc(n3)CC(=O)C[C@H](O)C=C(C)C=CCNC(=O)C=C[C@@H](C)[C@@H](C(C)C)OC(=O)[C@@H]12
User: Can you {#give me|create|generate!} the {SMILES__description} of a molecule that is a {CYP3A4_Substrate#not &NULL}{CYP3A4_Substrate__names__noun}?
Assistant: {#Yes|Of course|Sure|Yes, I'm happy to help!}, here you go: {SMILES#}