User: Is the molecule with the SMILES COC1=CC(=O)C[C@@H](C)[C@]12Oc1c(Cl)c(OC)cc(OC)c1C2=O metabolized by CYP3A4?
Assistant: No, it is not a CYP P450 3A4 substrate.
User: Is the molecule with the {SMILES__description} {SMILES#} {CYP3A4_Substrate__names__verb}?
Assistant: {CYP3A4_Substrate#No&Yes}, it is {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}.