Task: Please answer the multiple choice question.
Question: Which molecules are not a substrate for CYP3A4?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
(a) C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
(b) Cc1ccnc2c1NC(=O)c1cccnc1N2C1CC1
(c) Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1
(d) CC(C)(Oc1ccc([C@@H]2CC2(Cl)Cl)cc1)C(=O)O
(e) Cc1nc(C)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CC2
Answer: c
Task: Please answer the multiple choice question.
Question: Which molecules are {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%CYP3A4_Substrate%}
Answer: {%multiple_choice_result}