Task: Please answer the multiple choice question.
Question: Which molecules are not a CYP3A4 substrate?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a. O=C(CO)NCCCOc1cccc(CN2CCCCC2)c1
b. Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1
c. Cc1cccc(Nc2ccncc2S(=O)(=O)NC(=O)NC(C)C)c1
d. CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C
e. O=C1CN=C(c2ccccc2Cl)c2cc([N+](=O)[O-])ccc2N1
Answer: a, c
Task: Please answer the multiple choice question.
Question: Which molecules are {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%CYP3A4_Substrate%}
Answer: {%multiple_choice_result}