Task: Please answer the multiple choice question.
Question: Which molecules are not a CYP3A4 substrate?
Constraint: You must select none, one or more options from a, b, or c without using any other words.
Options:
a: COc1ccc(CN2CCNCC2)c(OC)c1OC
b: O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1
c: CCOC(=O)c1cncn1[C@H](C)c1ccccc1
Answer: a, c
Task: Please answer the multiple choice question.
Question: Which molecules are {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%CYP3A4_Substrate%}
Answer: {%multiple_choice_result}