User: I want to generate a SMILES.
Assistant: This sounds very exciting. Should it be a special one?
User: Yes, the molecule should not be a substrate for CYP P450 3A4.
Assistant: Got it, this SMILES is not a substrate for CYP P450 3A4: CC1=C(C(=O)OCCN(Cc2ccccc2)c2ccccc2)[C@H](c2cccc([N+](=O)[O-])c2)C(P2(=O)OCC(C)(C)CO2)=C(C)N1
User: I want to {#come up with|create|generate!} a {#molecule |!}{SMILES__description}.
Assistant: {#This sounds very exciting. |This sounds very interesting. !}Should it be a special {#molecule|one!}?
User: Yes, the molecule should {CYP3A4_Substrate#not &NULL}be a {CYP3A4_Substrate__names__noun}.
Assistant: {#Understood|Got it|Ok!}, this {SMILES__description} is {CYP3A4_Substrate#not &NULL}a {CYP3A4_Substrate__names__noun}: {SMILES#}