Problem statement: Answer the multiple-choice question.
Question: Which drug has a -25.723% hERG inhibition at a concentration of 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a. CCS(=O)(=O)Nc1cccc(C2=NN(S(=O)(=O)CC)C(c3cccs3)C2)c1
b. CCOc1ncccc1C(=O)OCC(=O)N(CC(C)C)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O
c. CC[C@@]12C(=O)N(c3cccc(C)c3)C(=O)N1[C@H](c1ccc(Br)cc1)[C@@H]1C(=O)N(C(C)(C)C)C(=O)[C@@H]12
d. Cc1ccc(-c2nnn(CC(=O)N(Cc3ccccc3F)C(C(=O)NC3CCCC3)c3ccncc3)n2)o1
e. COc1cc(OC)c(NC(=O)[C@@H]2CCC(=O)N2C2OC(=O)c3c2ccc(OC)c3OC)cc1Cl
Answer: e. COc1cc(OC)c(NC(=O)[C@@H]2CCC(=O)N2C2OC(=O)c3c2ccc(OC)c3OC)cc1Cl
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COc1cc(OC)c(NC(=O)[C@@H]2CCC(=O)N2C2OC(=O)c3c2ccc(OC)c3OC)cc1Cl
COc1cc(OC)c(NC(=O)[C@@H]2CCC(=O)N2C2OC(=O)c3c2ccc(OC)c3OC)cc1Cl
(2S)-N-(5-chloro-2,4-dimethoxyphenyl)-1-(4,5-dimethoxy-3-oxo-1H-2-benzofuran-1-yl)-5-oxopyrrolidine-2-carboxamide