Problem statement: Answer the multiple-choice question.
Question: Which drug exhibits a -23.544% human ether-à-go-go related gene (hERG) inhibition at a concentration of 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a. COc1cccc(CNC(=O)COc2cccc3c2OC(C)(C)C3)c1
b. COc1ccc(N2CC(NC(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1
c. Cc1nn(-c2ccccc2)c(C)c1/C=C/C(=O)OC(C)C(=O)Nc1ncc(Cl)cc1Cl
d. Cn1c(N/N=C/c2c[nH]c3ccccc23)nc2ccccc21
e. Cn1[nH]c(=O)c2ccccc2c1=O
Answer: b. COc1ccc(N2CC(NC(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COc1ccc(N2CC(NC(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1
COc1ccc(N2CC(NC(=O)N3CCN(c4ccccc4)CC3)CC2=O)cc1
N-[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]-4-phenylpiperazine-1-carboxamide