Problem statement: Answer the MCQ question.
Question: Which compound has a -26.541% human ether-à-go-go related gene (hERG) inhibition at 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
a) O=C(NCC1CCN(Cc2ccccc2F)CC1)Nc1ccc(F)cc1F
b) CN(C)/C=C/C(=O)c1ccc(F)cc1F
c) COc1ccc(CCNC(=O)c2cc(-c3cc(C)c(C)cc3O)n[nH]2)cc1OC
d) COc1cccc(C(=O)CSc2nnc(-c3cccs3)o2)c1
e) CCCC[C@H]1C2=C3[C@@H](CC(C(=O)OC)=C[C@@H](C(=O)OC)[C@H]3C(C)(C)C2=O)n2c(=O)n(-c3ccccc3)c(=O)n21
Answer: e. CCCC[C@H]1C2=C3[C@@H](CC(C(=O)OC)=C[C@@H](C(=O)OC)[C@H]3C(C)(C)C2=O)n2c(=O)n(-c3ccccc3)c(=O)n21
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
CCCC[C@H]1C2=C3[C@@H](CC(C(=O)OC)=C[C@@H](C(=O)OC)[C@H]3C(C)(C)C2=O)n2c(=O)n(-c3ccccc3)c(=O)n21
CCCC[C@H]1C2=C3[C@@H](CC(C(=O)OC)=C[C@@H](C(=O)OC)[C@H]3C(C)(C)C2=O)n2c(=O)n(-c3ccccc3)c(=O)n21
dimethyl (4R,5R,9R,15S)-15-butyl-3,3-dimethyl-2,11,13-trioxo-12-phenyl-10,12,14-triazatetracyclo[7.6.1.04,16.010,14]hexadeca-1(16),6-diene-5,7-dicarboxylate