Problem statement: Answer the multiple-choice question.
Question: Which compound exhibits a 16.655% human ether-à-go-go related gene (hERG) inhibition at a concentration of 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
[a] O=C(O)CC(c1ccc(Cl)cc1)N1Cc2ccccc2C1=O
[b] O=C(NCCc1c[nH]c2ccccc12)C(=O)NCC1CCCO1
[c] CCC(C)(C)C1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C(F)(F)F)ccc1N1CCOCC1)C2=O
[d] COc1cc(NS(=O)(=O)c2ccc(-c3ccc(=O)[nH]n3)o2)cc(OC)c1OC
[e] COc1nc(NC(C)=O)nc(C)c1Br
Answer: c. CCC(C)(C)C1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C(F)(F)F)ccc1N1CCOCC1)C2=O
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
CCC(C)(C)C1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C(F)(F)F)ccc1N1CCOCC1)C2=O
CCC(C)(C)C1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C(F)(F)F)ccc1N1CCOCC1)C2=O
2-[8-(2-methylbutan-2-yl)-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl]-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]acetamide