Problem statement: Answer the MCQ question.
Query: Which drug has a -8.343% human ether-à-go-go related gene (hERG) inhibition at a concentration of 10uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any additional words.
Options:
a. CCOc1ccc(N(C(C)C(=O)NC2CCCCCC2)S(C)(=O)=O)cc1
b. O=C(Oc1cncc(Cl)c1)c1sccc1Cl
c. Cc1ccc2nc(N3CCN(S(=O)(=O)c4ccc(C)c(Cl)c4)CC3)c(C#N)cc2c1
d. COC(=O)C1=C(C)OC(N)=C(C#N)C1c1ccccc1F
e. Cc1ccccc1OCC(=O)NNC(=O)C1CCCCC1C(=O)O
Answer: d. COC(=O)C1=C(C)OC(N)=C(C#N)C1c1ccccc1F
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_10uM#}{herg_central_at_10uM__units} {herg_central_at_10uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_10uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COC(=O)C1=C(C)OC(N)=C(C#N)C1c1ccccc1F
COC(=O)C1=C(C)OC(N)=C(C#N)C1c1ccccc1F
methyl 6-amino-5-cyano-4-(2-fluorophenyl)-2-methyl-4H-pyran-3-carboxylate