Problem statement: Answer the multiple choice question.
Question: What is the hERG inhibition at a concentration of 10uM of a drug with the SMILES COC(=O)Cc1[nH]nc2c1C1(C(=O)N(Cc3ccc(Cl)cc3)c3ccccc31)C(C#N)=C(N)O2?
Constraint: You must return none, one or more options from a, b, c, d, or e without using any additional words.
Options:
(a) 18.211
(b) 11.540
(c) -28.582
(d) -73.416
(e) -1.298
Answer: e. -1.298%.
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: What is the {herg_central_at_10uM__names__noun} of a {#compound|drug!} with the {SMILES__description} {SMILES#}?
Constraint: You must return none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{herg_central_at_10uM%SMILES%}
Answer: {%multiple_choice_result}. {herg_central_at_10uM#}{herg_central_at_10uM__units}.
COC(=O)Cc1[nH]nc2c1C1(C(=O)N(Cc3ccc(Cl)cc3)c3ccccc31)C(C#N)=C(N)O2
COC(=O)Cc1[nH]nc2c1C1(C(=O)N(Cc3ccc(Cl)cc3)c3ccccc31)C(C#N)=C(N)O2
methyl 2-[6-amino-1'-[(4-chlorophenyl)methyl]-5-cyano-2'-oxospiro[2H-pyrano[2,3-c]pyrazole-4,3'-indole]-3-yl]acetate