Problem statement: Answer the MCQ question.
Query: Which drug has a -15.954\% hERG inhibition at a concentration of 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a COc1ccc(CSc2nc3nc(C)cc(C)n3n2)cc1F
b Cc1nc(-c2nc(C(=O)NNS(C)(=O)=O)cs2)cs1
c COC(/C=C/Nc1ccc(Cl)cc1)=C(C#N)C#N
d Cc1ccc(CNC(=O)CCN2C(=O)[C@@H]3Cc4ccccc4CN3C2=O)cc1
e O=C(Nc1ccc(Cl)c(Cl)c1)C1C2C=CC3(O2)C1C(=O)N(CCN1CCCCC1)C3C(=O)NC1CCCCC1
Answer: e. O=C(Nc1ccc(Cl)c(Cl)c1)C1C2C=CC3(O2)C1C(=O)N(CCN1CCCCC1)C3C(=O)NC1CCCCC1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
O=C(Nc1ccc(Cl)c(Cl)c1)C1C2C=CC3(O2)C1C(=O)N(CCN1CCCCC1)C3C(=O)NC1CCCCC1
O=C(Nc1ccc(Cl)c(Cl)c1)C1C2C=CC3(O2)C1C(=O)N(CCN1CCCCC1)C3C(=O)NC1CCCCC1
2-N-cyclohexyl-6-N-(3,4-dichlorophenyl)-4-oxo-3-(2-piperidin-1-ylethyl)-10-oxa-3-azatricyclo[5.2.1.01,5]dec-8-ene-2,6-dicarboxamide