Problem statement: Answer the multiple choice question.
Query: Which compound has a -1.623\% human ether-à-go-go related gene (hERG) inhibition at 1uM?
Constraint: You must select none, one or more options from a, b, c, d, or e without using any other words.
Options:
a) FC(F)Oc1ccc(NC(=S)N2CCc3ccccc32)cc1
b) C1=CC2c3ccccc3NC(c3ccncc3)C2C1
c) COc1ccc(N2C(=O)CC(N3CCN(S(=O)(=O)c4c(C)cc(C)cc4C)CC3)C2=O)cc1
d) CCOC(=O)c1cnc(-c2ccccc2)nc1N(C)C
e) CCN(CC(=O)Nc1c(F)cccc1F)C(=O)/C=C/c1ccc(C)o1
Answer: c. COc1ccc(N2C(=O)CC(N3CCN(S(=O)(=O)c4c(C)cc(C)cc4C)CC3)C2=O)cc1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COc1ccc(N2C(=O)CC(N3CCN(S(=O)(=O)c4c(C)cc(C)cc4C)CC3)C2=O)cc1
COc1ccc(N2C(=O)CC(N3CCN(S(=O)(=O)c4c(C)cc(C)cc4C)CC3)C2=O)cc1
1-(4-methoxyphenyl)-3-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione