Problem statement: Answer the MCQ question.
Query: Which drug has a -81.690\% human ether-à-go-go related gene (hERG) inhibition at 1uM?
Constraint: You must select none, one or more options from a, b, c, or d without using any additional words.
Options:
a) NC(=O)c1ccc(-n2nnnc2SCc2ccc(F)cc2)cc1
b) COC(=O)c1ccc(CN2CCC(CO)(CCOc3ccccc3)CC2)cc1
c) CCOc1ccccc1NC(=O)C1CCCN(c2c(CC)c(C)nc3ncnn23)C1
d) O=C(NC1CCCC1)C(c1ccc(F)cc1)N(C(=O)c1csnn1)C1CCCC1
Answer: b. COC(=O)c1ccc(CN2CCC(CO)(CCOc3ccccc3)CC2)cc1
{#Task|Problem statement!}: Answer the {#multiple choice|multiple-choice|MCQ!} question.
{#Question|Query!}: Which {#compound|drug!} {#has|exhibits!} a {herg_central_at_1uM#}{herg_central_at_1uM__units} {herg_central_at_1uM__names__noun}?
Constraint: You must select none, one or more options from {%multiple_choice_enum%2-5%aA1} without using any {#other|additional!} words.
Options:
{SMILES%herg_central_at_1uM%}
Answer: {%multiple_choice_result}. {SMILES#}
COC(=O)c1ccc(CN2CCC(CO)(CCOc3ccccc3)CC2)cc1
COC(=O)c1ccc(CN2CCC(CO)(CCOc3ccccc3)CC2)cc1
methyl 4-[[4-(hydroxymethyl)-4-(2-phenoxyethyl)piperidin-1-yl]methyl]benzoate