Eight years ago, two former Stanford University postdoctoral fellows, one of them still in California and the other at the Harvard Stem Cell Institute (HSCI) in Cambridge, began exchanging theories about why patients with leukemia stop producing healthy blood cells. What was it, they asked, that caused bone marrow to stop producing normal blood-producing cells?And after almost a decade of bicoastal collaboration, Emmanuelle Passegué, now a professor in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at the University of California, San Francisco, and Amy Wagers, a professor in Harvard’s Department of Stem Cell and Regenerative Biology, have the answer.They have found that cancer stem cells actively remodel the environment of the bone marrow, where blood cells are formed, so that it is hospitable only to diseased cells. This finding could influence the effectiveness of bone marrow transplants, currently the only cure for late-stage leukemia, but with a 25 percent success rate due to repopulation of residual cancer cells.University of California Professor Emmanuelle Passegué (right) also worked with Koen Schepers, who was the first author on the study. Schepers is now at the University Medical Center Utrecht. Photo by Cindy ChewTheir results, which were recently published online in Cell Stem Cell, show that leukemia cells cannot replicate in the bone marrow niche as well as healthy blood-forming stem cells can, so the cancer cells gain the advantage by triggering bone marrow-maintenance cells to deposit collagen and inflammatory proteins, leading to fibrosis — or scarring — of the bone marrow cavity.“They remodel the microenvironment so that it is basically callous, kicking the normal stem cells out of the bone marrow and encouraging the production of even more leukemic cells,” Passegué said. This model is a shift from the widely held theory that cancer cells simply crowd out the healthy cells.Passegué and Wagers stayed in touch, despite the distance between their laboratories, via annual, two-day, “off-the-record” symposiums of junior investigators at the Harvard Stem Cell Institute and the California Institute for Regenerative Medicine (CIRM). The meetings, which began in 2005 and have continued, require all registrants to keep presentations no longer than 15 minutes and only to discuss unpublished work. “It’s sort of Las Vegas rules,” Wagers said.At the second such meeting, Passegué was intrigued by Wagers’ cell isolation-based approach to studying the bone marrow niche, the environment where stem cells are found. In the ensuing years, the two scientists swapped protocols, chemical reagents, mice, and even postdoctoral researchers in the pursuit of discovering what causes healthy blood cell dysfunction in leukemia. “Wagers was really involved as a creative spirit in the development of this story,” Passegué said.The observation that leukemia cells can remodel the bone marrow niche parallels work done by HSCI co-director David Scadden of the Harvard-affiliated Massachusetts General Hospital, who demonstrated that particular genetic modifications of bone-forming cells initiate changes in the marrow cavity that suppress normal blood formation and promote the emergence of leukemic cells. “So there’s this bidirectional communication that’s self-reinforcing, “Wagers said. “And if there’s a communication loop like that, you can think about interrupting in many different ways.”Passegué wants to understand how bone-marrow support cells are manipulated to sustain leukemia cells, instead of normal blood cells, in order to design therapies that block these detrimental changes. In the short term, her work could explain why 75 percent of bone marrow transplants are unsuccessful. “A poor niche is likely a very important contributing factor for failure to engraft,” she said. Her lab has shown that fibrotic bone marrow conditions can be reversed in as little as a few months by removing the bad-acting maintenance cells, and she is now investigating how to restore the healthy bone marrow environment in leukemia patients.Passegué and Wagers believe the success of this research reflects the value of scientific partnerships. “Both HSCI and CIRM understand the importance of fostering the open communication and collaboration that drives innovation in science,” Wagers said. The 2013 HSCI/California Junior Faculty Symposium will take place Nov. 8 and 9 at the University of California, Los Angeles.Koen Schepers, now at the University Medical Center Utrecht, was the first author on this study. The work was supported by the National Institutes of Health, CIRM, a NWO Rubicon Fellowship, and a KWF Fellowship.
The article states, “We believe that NVT is a plausible component of the WNV transmission cycle that may have contributed to its rapid spread in North America.” In particular, the results suggest that horses that are immune to WNV because of vaccination may be playing a role in transmission. In all five trials, some initially uninfected mosquitoes became infected, even though the 1-hour feeding time was too short for the mouse to become viremic, the authors report. Of 470 “recipient” mosquitoes that were tested for WNV, 18 became infected, for an average infection rate of 3.8%. In one trial, a 2.3% infection rate was found among 87 previously uninfected mosquitoes that had fed next to one infected mosquito. The current understanding is that mosquitoes contract WNV when they bite infected birds, which carry the virus in their blood. Infected mosquitoes then pass the virus to humans by biting them. Animals that are not susceptible to WNV are believed to be “dead-end hosts” that cannot pass the virus to uninfected mosquitoes. However, at this point the findings don’t necessarily imply a need for changes in WNV control measures, nor do they suggest an increased risk of human cases, Higgs said. Higgs S, Schneider BS, Vanlandingham Dana L, et al. Nonviremic transmission of west Nile virus. Proc Natl Acad Sci 2005 Jun 21;102(25):8871-4 [Full text] The report says most mammals are regarded as dead-end hosts for WNV because they either are not susceptible or because they become infected at too low a level to pass the virus on to biting insects. But the new findings suggests that mammals can play a role in transmission even if they aren’t susceptible to the virus or have immunity through vaccination. “If this is happening in the field, it has two consequences,” Higgs told CIDRAP News. “Transmission time is accelerated because you don’t depend on animals becoming viremic. And if you don’t need viremic animals to be involved, it means that any animal could transmit the virus.” But the new study indicates that mosquitoes can pick up the virus from carrier mosquitoes by feeding on the same host animal at the same time, even if the animal doesn’t have the virus in its bloodstream. The researchers call this “nonviremic transmission” (NVT). Jun 24, 2005 (CIDRAP News) The range of animal species that can contribute to the spread of West Nile virus (WNV) may be much broader than experts have believed, according to a study published recently in the Proceedings of the National Academy of Sciences. Higgs said he doesn’t yet understand how nonviremic transmission occurs. “That’s a darn good question,” he said, adding that he plans several more experiments to try to find the answer. “In terms of control measures and things, we can’t say that anything needs to be different. People are still going to have to do the same things,” he said. Also, “Just because we’ve seen this, it doesn’t influence transmission in terms of numbersit’s not going to have an effect on the number of West Nile cases.” The investigators allowed infected mosquitoes in a container sealed with nylon mesh to feed on an anesthetized, uninfected mouse by placing the mouse over the container. After the uninfected mosquitoes had fed for 5 minutes, a sealed carton containing uninfected mosquitoes was placed next to the first carton, and the mouse was positioned to lie over both cartons. Both infected and uninfected mosquitoes were then allowed to feed on the mouse for an hour, after which the mouse was euthanized and its blood serum was analyzed. The experiment was done five times. An experiment showed that mosquitoes can pick up WNV just by feeding on an uninfected mouse at the same time infected mosquitoes feed on it, according to the report by Stephen T. Higgs, an associate professor in the pathology department at the University of Texas Medical Branch, Galveston, and colleagues. “The population of vertebrates that may contribute to the WNV transmission cycle is probably much greater than was previously believed,” the article says. The authors say this may help explain why the virus spread across North America so quickly. The virus first emerged in New York City in 1999 and has spread to most US states and Canada since then.
Catherine Marie Hedger, age 64, of North Vernon passed away on Monday October 14, 2019 surrounded by her family and close friends. Catherine was born in Hamilton Ohio on October 29, 1954 the daughter of the late Chester and Mary Lou (Ritchie) Collins. She grew up outside of Osgood and attended school at South Ripley.After school she would marry Stanley Hedger and they raised 2 daughters. Stanley preceded her in death, and she would marry Anthony Tucker on April 9, 2015 and he survives. Catherine worked for several years in custodian supervision for hospitals and nursing homes. She grew up in Osgood, but lived several years in the Hope, In area.Catherine loved her family and spending time with them. She enjoyed baking, growing flowers, and fishing, even with her fear of water.She will be deeply missed by husband Anthony, daughters Peggy (Kamron) Bush of North Vernon and Karen (Timmy) McNally of Brownstown, brother Roy (Penny) Lee Collins of Butlerville, sisters Judy (Roark) Spurlock of Moores Hill and Pauline Cyrus (Dallas) Richter of Aurora, 3 grand children and 5 great grandchildren, and special friend Connie Arnett of Osgood.Visitation will be held on Wednesday October 23, 2019 from 1-3 pm. at Neal’s Funeral Home in Osgood, followed by Funeral services at 3 pm. Burial will follow at Perseverance Cemetery outside of Osgood.
Sadam Juma celebrates after scoring as KCCA FC destroyed FUS Rabat 3-1 at Lugogo on Sunday. PHOTO BY KCCA MEDIATodayKCCA FC ?? 3 FUS Rabat ?? 1Rivers Utd 0 Club Africain 2July 7Africain v KCCA, & FUS v Rivers 11pmJohannesburg, South Africa | AFP | Midfielder ace Sadam Juma showed why KCCA FC went out of the way to sign him mid-season with a beauty goal Sunday that sealed a decisive 3-1 victory for the Kampala side over visiting Moroccans FUS Rabat.The victory puts Mike Mutebi’s KCCA FC joint top of Group A, and firmly back in the running for a CAF Confederation Cup quarter-finals place with a final game against Club Africain left.“Juma’s first goal! Technique, timing & execution – manager Mutebi’s dream,” is how sports journalist Andrew Mwanghuya described the KCCA FC performance on twitter.Another veteran sports journalist Ahmed Hussein added: “Saddam Juma’s goal a beauty to watch anytime to kill off serious stress, ” while Harold Atukwatse concluded that ” Sadam Juma is a gem. Such a joy to watch.” Ex-international David Obua said: “told people before, about Coach Mike Mutebi and these wonderful players! Sadam Juma, Mutyaba and the skillful Nunda will mesmerise you.”Mark Namanya summed it up this way: “KCCA playing sexy football at Lugogo. Moroccan side Rabat dont know what has hit them. The combo of Juma-Mutyaba-Nunda is purism personified.” Club Africain shocks Rivers UnitedIt was a great day for Tunisia in the Confederation Cup as Club Africain ended a run of nine home wins in Group A by winning 2-0 away to Rivers United of Nigeria to go top.Manoubi Haddad scored direct from a free-kick after 63 minutes in wet Port Harcourt and Rivers captain Festus Austine deflected a low cross into his net two minutes from time.Kampala Capital City Authority of Uganda trail Club Africain on goal difference after an impressive 3-1 home triumph over 2010 Confederation Cup winners FUS Rabat of Morocco.Geoffrey Sserunkuma gave Kampala a half-time lead that was stretched to three goals by Saddam Juma and Isaac Muleme before Lamine Diakite grabbed a late consolation goal.Club Africain and Kampala have nine points and FUS and Rivers six, leaving all four teams in contention ahead of the final fixtures next Friday.Standings (played, won, drawn, lost, goals for, goals against, points)Africain 5 3 0 2 9 6 9KCCA 5 3 0 2 7 8 9FUS 5 2 0 3 7 6 6Rivers 5 2 0 3 5 8 6Tweets about @KCCAFC Share on: WhatsApp
Sears is a 1984 graduate and a member of the cheerleading squad. She attended Robert Morris University and finished with a bachelor’s degree in 1989. In 2004, she received a master’s in public administration from the University of Pittsburgh. She currently works as a minority and women’s business specialist for the Pittsburgh Board of Education. “It was a great thing to see,” Sears said. “I think the idea worked out well. The atmosphere was pleasant.”Peabody will close after this season. Quarterback Dontae Forte crossed the goal line for the Highlanders to make sure the team’s supporters would not forget its side in this prolific East End rivalry.“(The Peabody community) is not happy about this,” said athletic director Liza Simmons. “It was a struggle to get the alumni to even come out. The Highlander name no longer exists. The Bulldog will remain, that’s what’s hard to accept.”Former Westinghouse coach George Webb led the Bulldogs for three decades and is looked at by many as a legend. He also expressed opinions on the end of the rivalry.“I’ve seen this happen on many occasions,” Webb said. “It happened with Fifth Avenue, Allegheny, South Hills, South Vo-Tech, and most recently, Peabody and Schenley. What has happened is they’ve phased out the community school. Especially the ones in underprivileged communities and mostly within the past 20 years. I try to stay out of the way, but I know the people that I’ve spoken with about this aren’t happy. Who would, knowing that the place that they are proud of will no longer exist.”Jaylen Coleman scored on a 63-yard pass from Forte to open the scoring, then, Westinghouse answered when Tirell Harris fell on a fumble in the end zone to tie the score at 6-6.Despite the discouraging nature of the situation for Peabody fans, after the game, both Westinghouse and Peabody went on the field in a sign of unity.“We were glad to see so many people show up and support this event,” Sears added. Both sides were in unity and it turned out to be something many will remember.”(Malik Vincent can be reached at [email protected]) by Malik Vincent For New Pittsburgh Courier Peabody and Westinghouse closed out their storied histories with a game for the ages as they went to overtime. The Highlanders came out on top, 12-6.At halftime, Westinghouse’s alumni were acknowledged. “People appreciated the acknowledgement,” said Rhonda Sears, executive director of Westinghouse’s alumni association. “When their names were called, people screamed and chanted. There were also many people there with their Westinghouse apparel and things that represented the program well.” SHOW OF UNITY—Peabody and Westinghouse players join together in the center of the field in a show of unity Oct. 16, at Cupples Stadium. The Bulldogs lost 12-6 in the final meeting between these teams. (Photos by Chris Lopez)
Baltus was named the Smoke Eaters’ Most Improved Player in 2011-12 and the team’s co-MVP this season. Last week he was named to the Interior Conference’s Second All-Star Team.“Brent’s been my offensive leader all season long,” said head coach/general manager Bill Birks. “He’s put in the hard work and it’s extremely rewarding for our program to see him honoured by the league in this way.”Baltus is the first Smoke Eater to be awarded the Vern Dye Memorial Trophy, given to the MVPs from both the Interior and Coastal Conferences. This year’s Coastal Conference MVP is Chilliwack Chiefs goaltender Mitch Gillam.Baltus is also the first Smoke Eater to win a major BCHL award since Justin St. Louis was named Interior Conference Rookie of the Year in 2004.The BCHL announced its 2012-13 award winners Tuesday. The winners were chosen following a survey of BCHL coaches.Trail was eliminated from the post season by Salmon Arm during the final weekend of the season.Salmon Arm finished the season with 58 points, four more than Trail in the race for the final playoff spot in the Interior Division. The Trail Smoke Eaters didn’t advance into the B.C. Hockey League playoffs, but that didn’t stop forward Brent Baltus from being named the 2012-13 Interior Conference Most Valuable Player.Baltus, 20, led the Smoke Eaters in scoring this season with 24 goals and 52 points, including two shorthanded markers and three game-winning goals.In 116 career BCHL games with Trail, Nanaimo and Alberni Valley, the Nanaimo product tallied 38 goals and 83 points. Baltus is committed to the NCAA Division I Alaska-Anchorage Seawolves for the 2013-14 season.
Plants have both an intranet and an extranet. Some recent papers investigated further about how plants, though rooted in the ground, keep in touch with the inside and outside economy.Intranet: In 2001 (07/13/2001), and periodically since (10/04/2004, 11/09/2004) we reported the current thinking about how a plant knows when to flower, and described a kind of email system the plant uses to keep in touch with itself. Scientists have been hot on the trail of the mysterious “florigen” (whatever it is) that travels through the vessels to the growing tip and turns on the flowering process. They have known since 1865 that something travels from a sunlit leaf to the apical meristem where flowers are produced. Now, according to both Science April 20 and Nature April 26, they think the packet is not the messenger RNA from the FT gene, as previously announced (08/12/2005), but the protein it encodes. Understanding what the protein does upon receipt is an obvious next step. Then, what in a leaf triggers the email to be sent? And is the packet sent throughout the entire plant? For now, the botanist hackers are just trying to get good at sniffing the internet to find the packets, let alone decode the payload. Down below, at the root level, what happens? A European team reporting in Current Biology thinks they have unmasked the signals that turn on (or off) root cell differentiation: “Analysis of the root meristems of cytokinin mutants, spatial cytokinin depletion, and exogenous cytokinin application indicates that cytokinins act in a restricted region of the root meristem, where they antagonize a non-cell-autonomous cell-division signal, and we provide evidence that this signal is auxin.”Extranet; When plants need to talk to their neighbors through their own kind of VPN (virtual plant network, our joke), they waft volatile compounds into the air. Some of these compounds are chiral – they come in left- and right-handed forms. Scientists are just at the leading edge of understanding what these compounds are and what they do. A news item in Nature described the work of a team that flew a Lear Jet over the forest canopy to gather some of the compounds. “A sophisticated survey of certain volatile organic compounds in the air over forest ecosystems shows how such work can reveal varied emission patterns of different chiral, or mirror-image, forms of these compounds.” Plants emit more volatiles than animals by orders of magnitude, the article states. Some compounds can repel insect pests, while others can attract pollinators. This article described how the plant can send out different chiral forms of the same molecule for different purposes. Some, for instance, appear to be temperature dependent, while others are light dependent. “Volatile organic compounds have a fundamental role in the coexistence of the flora and fauna in ecosystems,” the article explains, “But there is still much to learn about the relationships and interactions between species that can be related to an effect of naturally produced compounds such as monoterpenes.” The compounds may vary by species, by individual plant, and even by tissues within the plant. The scientists are comparing forest emissions from South America, Suriname and Finland.The trees may not talk like the Ents in Lord of the Rings, but they do have a language that humans are just beginning to translate.Don’t talk to your plants unless you learn the language. Suggested learning tool: a Lear Jet.(Visited 12 times, 1 visits today)FacebookTwitterPinterestSave分享0
Nature is kind. That’s nice to know; but what was the context of the statement in New Scientist? “Occasionally, though, nature is kind and fossilisation preserves details of an animal’s soft tissue.” But has nature been kind for tens of millions of years? In an article called “Soft-centred fossils reveal dinosaurs’ true colours,” Jeff Hecht spilled the beans that more researchers are finding soft tissue and original material in dinosaur bones said to be over 65 million years old and older – even more than twice as old. We’ve seen news about soft tissue before (e.g., 12/22/2010), but this article suggests that scientists are becoming more bold to look for it (cf. 02/22/2006). Pete Larson, Phil Manning and Roy Wogelius, in particular, have been using synchrotron radiation at Stanford to look for unfossilized remains of dinosaurs. Hecht suggested that they are not alone; “Their project is one of several challenges to the conventional wisdom that when animals fossilise, all the original organic material, from the bones to the blood, is lost.” Their work could crack open old bones of contention: “First, however, researchers like Manning must convince other palaeontologists that their fossils really do preserve original material, which won’t be easy.” Other paleontologists have been skeptical, because “Convincing evidence of original soft tissue older than the Ice Age was lacking.” That’s because “DNA degrades much faster than proteins and other soft tissue components and nobody thinks it is possible to recover DNA that is older than about a million years.” Hecht explained that, while soft tissue imprints are exceptional but not unknown, preservation of actual original material has been controversial. Mary Schweitzer famously announced blood vessels, cells and other material in a T. rex femur in 2005 (03/24/2005), but “Schweitzer’s claim was met with scepticism, in part because of the immense age of the bone.” She countered skeptics’ arguments that she had only found recent biofilms (07/30/2008) and then announced finding collagen, haemoglobin, elastin and laminin – strengthening her discovery of original material (04/30/2009). Awaking from their dogmatic slumbers, more paleontologists have started on a soft tissue treasure hunt:Others have begun to report similar findings, and not just from inside bones. Manning and Wogelius have reported finding amino acids in the claw and skin of Dakota, the 66-million-year-old Edmontosaurus mummy (Proceedings of the Royal Society B, vol 276, p 3429). Meanwhile, Orr’s former student Maria McNamara, now splitting her time between Dublin and Yale, claims to have found marrow inside the fossilised bones of 10 million-year old frogs and salamanders preserved in lake-bed deposits from Spain (Geology, vol 34, p 641). Marrow is normally among the first tissues to decay, but she found organic residues preserved in three dimensions that retained the original colour and texture of the marrow. “The fidelity of preservation on a morphological level is remarkable, though it’s very unlikely that the biochemistry would be completely original,” says [Patrick] Orr [University College Dublin]. Preservation of very decay-prone soft tissues is probably more common than we realise, he adds.So what of the latest test at Stanford? Manning and Wogelius had been successful finding original pigment in an Archaeopteryx specimen in 2009 (05/10/2010), Hecht recalled; “Nobody had expected soft-tissue chemistry to be preserved in such places” as feathers. Quoting Wogelius, “It’s amazing that that chemistry is preserved after 150 million years.” Zinc and copper atoms were also detected with the synchrotron machine. Others have found “more surprises,” like melanosomes still intact in a bird feather said to be 108 million years old using a scanning electron microscope; ditto by another team in China.The new techniques have not yet answered any big questions about dinosaurs: researchers like Schweitzer and Manning have devoted much of their effort to persuading sceptics that their results are real. Eventually they think they will win over the doubters and revolutionise palaeontology, but in the meantime they have the satisfaction that drives on amateur and professional fossil hunters alike. “It’s quite amazing to discover something that has never been seen before,” says Wogelius.Unfortunately, Hecht left us hanging on whether Manning’s team found something at Stanford in their latest test. It sounds, though, like more announcements of original tissue preservation in fossils will be forthcoming, now that the credibility gap has been bridged. “The claims are controversial, but if true they promise to breathe new life into our understanding of ancient life,” Hecht said.You can read Hecht’s article and think, if you are intellectually lazy, “Isn’t this nice; science marches on.” But it means that science was marching in the wrong direction for a long, long time. The facts are making evolutionary paleontologists and geologists turn about face, with red faces: they didn’t expect to find soft tissue; they weren’t looking for soft tissue; and they couldn’t believe it when it was shown to them. Schweitzer and Manning are having to act like drill sergeants, barking to the troops that they have been marching in lock step in the wrong direction. There is only one group that is not surprised by these findings: the young-earth creationists. Yes, those despised, hated, expelled Henry Morris followers, relegated to the dregs of society by academia (both secular and theistic evolutionist camps), even shunned by many in the Intelligent Design community, are not at all surprised. Like their foes, they also cannot believe that DNA and protein can last for 80 to 150 million years – because they believe those long ages are a fiction. Now that the sleepers on EST (Evolution Standard Time) have been jolted awake, should we trust their alarm clocks? Should we grant them credibility now, when they say, “Well, I’ll be darned! DNA can survive for 150 million years!”? Many of them are sidestepping the fact that soft tissue preservation wreaks havoc on evolutionary age assumptions (cf. 06/03/2005). While these findings do not vindicate the young earth creationists beyond all doubt – there are still many questions and tests to be made – it sure looks like they have the ball, and the momentum is with them. So don’t let the evolutionists put Greek happy-masks over their red faces and spin this story with cheerful talk that such finds are going to “breathe new life into our understanding of ancient life” (how much did they understand before?), or that this is going to “revolutionize paleontology” somehow, in some vague, unspecified way. It ought to revolutionize it, all right: by dismantling the evolutionary timeline and re-opening some old, imprisoned questions about the history of the earth. See also the 01/28/2011 entry for more reasons to doubt the presumed authority of the moyboys.* Don’t let them grab the ball. Don’t let them make predictions that only a young-earth creationist would make, like “We expect more soft tissue will be found in dinosaur bones,” and then, when it is found, declare victory. The ball is headed toward the other goal line, and it will take impartial referees to call the fouls.(Visited 43 times, 1 visits today)FacebookTwitterPinterestSave分享0
Pakistan’s cricketing brothers Kamran and Umar Akmal have sent legal notices to alleged bookmaker Mazhar Majeed for implicating them in the spot-fixing scandal.Their lawyer Saud Nasrullah said that he had dispatched the legal notices to Majeed’s address in the United Kingdom in which the Pakistani bookmaker had been told to either give more details of the involvement of his clients or apologise.”Kamran and Umar are very upset by the allegations made by Mazhar Majeed and believe it is an attempt to defame them and hurt their reputation,” Nasrullah said.”Either he must come up with more details to back his statement that Kamran and Umar were involved with him in spot fixing or he must publicly apologise or face a suit for damages,” he said.Majeed, in a recent video shown on Geo News channel, is heard saying that he has seven Pakistani players working for him.Besides naming the three suspended players, Salman Butt, Muhammad Aamir and Muhammad Asif, Majeed also named the Akmal brothers, Imran Farhat and Wahab Riaz as the players working for him.Imran Farhat has already sent a legal notice to Majeed.Nasrullah said that the Akmal brothers felt that Majeed had tried to misuse his position as the agent for some Pakistani players and bring a bad name to the team.- With PTI inputs
The Manny Pacquiao-Adrien Broner fight took an interesting subplot after the American was reportedly arrested the day after Christmas for failing to attend a court hearing over a traffic violation.He was booked in jail but was immediately released, according to wire reports, over an outstanding 2017 warrant in Florida for speeding.ADVERTISEMENT Don’t miss out on the latest news and information. SEA Games: Biñan football stadium stands out in preparedness, completion Sports Related Videospowered by AdSparcRead Next View comments Private companies step in to help SEA Games hosting Hotel management clarifies SEAG footballers’ kikiam breakfast issue It’s nothing new for the brash 29-year-old Broner, who has had a previous brush with the law for sexual battery.But it was a blow for the American who has been diligently posting his training over his social media account in proving that he had already put his past troubles behind him.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSUrgent reply from Philippine football chiefPacquiao, on the other hand, skipped training and instead took his family to Disneyland right on the same day, according to Dr. Ed de la Vega, who crafts the mouthpiece used by the Filipino boxing great.Pacquiao, 40, is putting his WBA welterweight crown on the line against Broner on Jan. 19 at the MGM Grand in Las Vegas. LOOK: Joyce Pring goes public with engagement to Juancho Triviño PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss TS Kammuri to enter PAR possibly a day after SEA Games opening Legends tennis tournament caps Palawan season MOST READ LATEST STORIES SEA Games: Biñan football stadium stands out in preparedness, completion BREAKING: Corrections officer shot dead in front of Bilibid Is Luis Manzano planning to propose to Jessy Mendiola?