Survey of the currency bills in University of Uyo, for fungal contaminations revealed presence of fungal organisms such as species of Aspergilliusniger, Aspergillus fumigatus, penicillium spp, mucor spp, candida albicans,and Rhizopus spp. This study was carried out using a total of 101 samples of banknotes denomination (N5, N10, N20, N50, N100, N200, N500, and N1000) obtained from different points of collections within University of Uyo. The currencies were processed for fungal isolation using potato dextrose agar medium and streaking technique was employed for the isolation and purification of the colonies. Microscopic and Macroscopic examination revealed that N500 denomination had the highest incidence of organism, and samples from College of Science and Technology buttery were also the most contaminated. Paper money handling should include but not limited to carrying currency notes in wallets, envelops and holding with clean hands. The promotion of a cashless economy is also advocated; Nigerian paper money has been found in this study to be contaminated with Bacteria and could be vehicles for the transmission of fungal diseases of man.