The cut flower and bulb industry in California is an important part of the state's agricultural economy and it has relied heavily upon the use of methyl bromide as a treatment to control soil-borne pests. With the phase out of methyl bromide, it is important to develop alternatives that will maintain crop productivity. This report describes research testing the efficacy of propargyl bromide against selected nematode, fungal, and weed species. Three sites were selected in California to represent different soil types and environments. Propargyl bromide was applied to soil in large, buried containers at rates ranging from 28 to 168 kg·ha−1 and compared with standard soil fumigants. The citrus nematode (Tylenchulus semipenetrans Cobb) and an isolate of Fusarium oxysporum Schlechtend:Fr were both controlled at the lowest rate of propargyl bromide tested: 28 kg·ha−1. Weed species varied greatly in their sensitivity to propargyl bromide. A 100% reduction in common purslane (Portulaca oleracea L.) and pigweed (Amaranthus retroflexus L.) germination occurred at 112 kg·ha−1 propargyl bromide, regardless of geographical location. Results for annual bluegrass (Poa annua L.) control were more variable across locations and years, but more than 90% control was consistently achieved with 168 kg·ha−1 propargyl bromide. Cheeseweed (Malva parviflora L.) and field bindweed (Convolvulus arvensis L.) were never consistently controlled by propargyl bromide. When compared with the soil fumigants methyl bromide, iodomethane, and metam sodium, propargyl bromide provided comparable control of all soil-borne pests, but at much lower rates. Although higher rates of propargyl bromide, more than 112 kg·ha−1, were needed to control weeds, these rates still were almost half that required of the other standard fumigants.