EDITOR'S CHOICE IN IMMUNOLOGY
COURTESY OF ROBERT FUJINAMThe paper
M.F. Cusick et al., “Infiltrating macrophages are key to the development of seizures following virus infection,” J Virol, 87:1849-60, 2013.
Of the approximately 2.2 million Americans affected by epilepsy, a third do not respond to current antiseizure treatments, and nearly three quarters of all cases have unknown causes. Though scientists have previously linked more than 100 species of viruses that infect the central nervous system (CNS) to patients suffering from recurring seizures, the significance of viral infections in epilepsy is still unclear.
Researchers at the University of Utah School of Medicine, led by Robert Fujinami, had previously developed a mouse model that suffered from seizures after infection with a CNS-targeting virus. Though the mice could clear...