Chapter 23: Corticosteroids and Corticosteroid Antagonists
Which of the following is not an adverse effect of prolonged systemic glucocorticoid use?
c. Proximal muscle wasting
Which mechanism is partly responsible for the anti-inflammatory actions of glucocorticoids?
a. Increased production of arachidonic acid
b. Increased production of interleukin-1
c. Increased release of lymphocytes in circulation
d. Inhibition of white blood cell migration from circulation to affected tissue
Individuals with chronic adrenal cortical insufficiency (Addison’s disease) must receive exogenous glucocorticoids to survive.
Which of the following is not true regarding adrenal suppression that occurs as a result of chronic systemic glucocorticoid use?
a. Exogenous glucocorticoids must be discontinued when patients have a serious illness.
b. Adrenal suppression can occur when exogenous glucocorticoids are given for less than a month.
c. Higher doses of exogenous glucocorticoids are given when patients have a major surgery.
d. Individuals who have taken glucocorticoids for a long time have their doses tapered gradually to allow recovery of adrenal function.
Which of the following adverse drug reactions might be expected even after short-duration systemic glucocorticoid use?
Which strategy is not used to decrease the toxicity of glucocorticoids?
b. Dose tapering soon after therapeutic response
c. High oral doses for long durations
Which of the following conditions is likely to worsen with glucocorticoid injections?
d. Lateral epicondylalgia