By Naoyuki Taniguchi, Koichi Honke, Minoru Fukuda
This guide, now in a brand new, moment variation, is an important source for scientists with an curiosity within the function of glycosyltransferases and comparable genes concerned about the biosynthesis of glycoproteins, glycolipids, and proteoglycans.
The first version of the Handbook of Glycosyltransferases and comparable Genes, released in 2002, contained descriptions of greater than a hundred mammalian genes via over a hundred scientists who initially remoted and/or cloned those genes. due to the fact then, there was a starting to be physique of proof about the roles of glycosyltransferases, and extra glycosyltransferases were pointed out. Now greater than two hundred glycosyltransferases were remoted from mammalian tissue, akin to nearly 1–2% of the entire human genome. a few were came upon to be interested by improvement and copy, sign transduction, mobile loss of life, better frightened functioning, immunity, and different vital organic techniques. Glycosyltransferases have additionally been implicated within the improvement of way of life ailments resembling diabetes, melanoma, power obstructive lung affliction (COPD), neuromuscular illnesses, and infectious ailments.
A useful glycomics procedure utilizing gene concentrating on in mice and analytical tools using glycan arrays, lectin arrays, HPLC, and mass spectrometry pointed out the objective glycoprotein(s) on which glycans are hooked up by means of the catalytic response of glycosyltransferases. many of the aim proteins were proven to be mobile floor membrane proteins reminiscent of development issue receptors and transporters. The three-d buildings of a few glycosyltransferases have additionally been characterised, making it attainable to categorise them into keeping and inverting enzymes. Such structural details can be integrated during this important new edition.
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Additional info for Handbook of Glycosyltransferases and Related Genes
GalCer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ganglio Series . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Globo Series . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Further Reading . . . . . . . .
1273 Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, Dubbelhuis PF, Aten J, Kuipers F, Serlie MJ, Wennekes T, Sethi JK, O’Rahilly S, Overkleeft HS (2007) Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes 56:1341–1349. 2337/db06-1619 Alfonso P, Navascue´s J, Navarro S, Medina P, Bolado-Carrancio A, Andreu V, Iru´n P, Rodrı´guezRey JC, Pocovı´ M, Espan˜a F, Giraldo P (2013) Characterization of Variants in the Glucosylceramide Synthase Gene and their Association with Type 1 Gaucher Disease Severity.
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Handbook of Glycosyltransferases and Related Genes by Naoyuki Taniguchi, Koichi Honke, Minoru Fukuda