Over the last decades, several heterocyclic derivatives compounds have been synthesized or
extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of
these heterocyclic derivatives. These compounds consist of an oxygen-containing central heterocyclic structure
with two more cyclic structures fused to the central cyclic compound. It has been shown that xanthane
derivatives are bioactive compounds with diverse activities such as anti-bacterial, anti-fungal, anti-cancer, and
anti-inflammatory as well as therapeutic effects on diabetes and Alzheimer. The anti-cancer activity of such
compounds has been one of the main research fields in pharmaceutical chemistry. Due to this diverse
biological activity, xanthene core derivatives are still an attractive research field for both academia and
industry. This review addresses the current finding on the biological activities of xanthene derivatives and
discussed in detail some aspects of their structure-activity relationship (SAR).
Keywords: Xanthene, structure-activity relationship (SAR), biological activity, polycyclic, natural resources, pharmaceutical activities.
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