The aging procedure in humans is intrinsically tied to NAD or nicotinamide adenine dinucleotide, an important cellular component that contributes to several biological procedures. However, the body’s NAD-producing ability deteriorates with time, thus showing signs of aging.
But there’s a solution! Scientists have stated that NAD precursors, like NMN or nicotinamide mononucleotide, can improve NAD production, thus slowing down the biological clock.
An instant NAD precursor, NMN, comes with the Slc12a8 transporter that transfers the NMN molecule into the cells, where it is used to produce NAD. Though it is naturally available in different vegetables and fruits, NMN supplementation is a wiser idea. Read on to further understand NAD and NMN and their real advantages in slowing down the effects of cell aging on the human body.
1. May Promote Longevity
Mitochondria, or the cell powerhouse, starts decreasing and getting impaired with age, largely due to a decrease in NAD+ levels. Cell aging further leads to cellular senescence, where the cells stop dividing and lose function. However, such cells do not leave the human body; they create damaging inflammatory elements that aggravate the aging procedure. And that’s where NMN comes into effective play.
When taken orally, NMN may get absorbed into the cells rapidly and convert into NAD, further increasing NAD biosynthesis to boost insulin secretion and action, suppress age-related adipose tissue inflammation, and improve neuronal brain function while also supporting physical activity, healthy weight gains, and energy metabolism, all linked to healthy aging.
Animal studies have shown that increasing NAD+ synthesis in the human body may extend the lifespan of flies, worms, and yeast. At the same time, rodent research suggests that proper NMN supplementation may mitigate the decrease in NAD+ levels and concurrent organ decline that can result in age-related problems. To reap the best NMN benefits, go for NMN supplements available online at some of the most reputable stores.
2. May Offer Cognitive Support
When there’s a decrease in brain NAD+ levels, the mitochondrial function is impaired, resulting in age-related cognitive decline. Nevertheless, Studies suggest replenishing NAD+ decline with NMN may reduce age-related mitochondrial and cellular dysfunction and degeneration.
As per research, NMN may inhibit beta-amyloid plaque formation related to neurological issues while improving spatial working memory, neurovascular health, and coordination in older mice.
Further studies show that NMN leads to complete neurovascular rejuvenation in older mice by improving the integrity and health of the brain and the cerebral blood flow system. Hence, finding the best NMN supplements to maintain neurovascular health has the potential to support varied age-related neurological conditions.
3. May Maintain Healthy Blood Sugar Levels
NAD metabolism is crucial for maintaining healthy blood sugar levels, and by making up for NAD deficiency, NMN has a bigger role to play in this procedure. Studies put down that long-term NMN administration in mice perfected age-related decline of the cells in the liver, fat, and muscles that do not respond well to taking up blood sugar.
NMN treatment may also improve age-related decrease in cells’ potential to use blood glucose effectively, which can further lead to blood sugar level buildup.
4. May Support Healthy Weight
Excessive body weight or obesity is a danger for chronic conditions, such as type 2 diabetes, high blood pressure, gallbladder disease, coronary heart disease, and stroke. Although obesity may occur at any age, older individuals might experience age-related weight gain because of declined metabolism.
Such individuals generally have lower levels of ATP and NAD, which further reduces energy production. Nevertheless, replenishing NAD stores with NMN may reverse the trend, improve metabolic pathways, and promote healthy weight.
Studies published in Cell Metabolism suggest that 100 to 300 mg NMN may reduce around 4% to 9% weight in older mice if administered continuously for 12 months. The best thing about NMN is that it does not reduce excessive body weight by suppressing appetite; instead, it increases oxygen consumption and energy expenditure.
Though there’s limited clinical evidence on whether NMN results in more energy, sufficient mice studies indicate an increase in endurance and stamina by around 80% with NMN. Anecdotal evidence also abounds in this category.
5. May Treat Infertility in Women of Advanced Age
As per studies in Cell Reports, reproductively aged female mice who received low NMN doses experienced improved fertility rates, better in vitro fertilization results, and decreased time to pregnancy. Since obesity is a major cause of infertility, NMN’s healthy weight management advantages rightly contribute to enhanced fertility and better pregnancy rates in older women.
6. May Improve Muscle Function
Regrettably, muscle function declines with age; skeletal mass and muscle strength diminish as early as the 30s, with many losing around 5% per decade. This major drop in the muscle potential of older individuals due to a decline in NAD levels takes a toll on independence and quality of life, further increasing the risk of fractures, frailty, and falls.
However, revitalizing NAD, the crucial coenzyme through its NMN precursor, may help prevent muscular decline and diminished physical strength. Studies by the University of Tokyo state that NMN improves muscle performance and strength indicators, such as walking speed and grip strength in older men.
Besides this, NMN also improves general fitness and conditioning levels by increasing NAD levels that break down glucose and fatty acids, which the muscles use to maintain their structure and remain strong.
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The Bottom Line
To conclude, NMN increases NAD, a coenzyme that may help metabolism, and more than 500 enzymatic reactions. Several studies have found that NMN reverses aging and promotes longevity, improving cell function and increasing lifespan.
Hence, by maintaining higher NAD levels through proper NMN supplementation, older individuals can ensure that vital procedures, like mitochondrial functionality, DNA repair, insulin production, and muscle regeneration, occur smoothly.