Primary lateral sclerosis
Also known as:
Central motor neuron disease, PLS
Primary lateral sclerosis (PLS) is a rare, neuromuscular disorder that affects the central motor neurons and is characterized by painless but progressive weakness and stiffness of the muscles of the legs. Such weakness may progress to affect the arms and the muscles at the base of the brain (bulbar muscles). Less frequently, the muscles of the face are affected. In most cases, the disorder affects adults during midlife. The exact cause of primary lateral sclerosis is unknown.
Providence ALS Center
is the only ALS Association-certified Center of Excellence in Oregon, offering a multidisciplinary approach to ensure ease and excellence. Our program emphasizes treatment, coordinated care, education and early intervention to manage symptoms.