With most of them in their 80s and 90s the commemoration is likely to be the last time the survivors come together to remember a battle that still serves as an inspiration to Jews and the state of Israel.
Out of around 750 who took up arms in the ferocious battle only three now survive, and out of those only one could travel to Poland to join a handful of Jewish civilians who were in the ghetto during the insurrection.
Confronted with the certainty of transportation to death camps that had reduced the ghetto's population from about 400,000 to 50,000, on April 19, 1943 the poorly armed Jewish resistance fighters fought back against overwhelming German forces in the full knowledge they faced almost certain death.
Symcha Ratajzer-Rotem, who fought in the ghetto, said: "We wanted to show them that we wouldn't be taken to the gas chambers."
"No words can describe what the Uprising was like, what the Holocaust was like, and what the bestiality of the Germans was like," he told an audience on the spot where 70 years ago the Jewish Combat Organisation, the biggest Jewish resistance group, had its headquarters.
"But despite the cruelty they didn't break the moral of the Jewish people." Bronislaw Komorowski, the president of Poland, said the Nazis has made the ghetto "hell on earth."
"The Uprising has become a reference point in the struggle for human dignity, and it was here in Poland that Polish Jews took up this struggle for human dignity," he added.