Symptoms like chills, shaking and fever are the body's way of trying to increase temperature through muscular activity. Chills are particularly common with certain cancer drugs such as interferon, interleukin-2,
Chills are nothing to be concerned about during chemotherapy, but it's unusual for them to persist months after the completion of treatment. They may indicate a separate medical problem, one that may or may not be related to your cancer treatment. One thing to consider is whether you are continuing to take any medications other than chemo that could be causing this side effect. Unless your doctor has advised against it, there's no reason not to treat chills with ibuprofen, acetaminophen, or aspirin. But because there are numerous causes of these symptoms and they've persisted for a long time, you should go to your medical practitioner to determine the specific treatment.
and tumor necrosis factor (TNF), but they can occur after treatment with most chemotherapy agents.