Jul, 2021 - By SMI
Scientists have pinpointed a protein to prohibit the tumor cells from penetrating into the blood stream by preventing metastasis.
Cancer is a very dangerous disease that becomes fatal when it is spread in the body of a human. Study conducted by the University of John Hopkins have now classified a protein that stops cells from entering the blood system and found that cancer cell disregard it. A new drug objective for the treatment of cancer may be revealed as a result of this study. When cancer is found in one part of the body, it drifts further into the blood system and then into the other parts of the body to forge a strong colony of the rouge cells. This metastasization process makes tracking and removing cancer much harder and tremendously fatal.
In answer to that, a key aspect of cancer research is how to avoid metastasis. Researchers have found proteins, molecules and protein transduction pathways which help tumors expand and provide a good starting point for producing therapeutic strategies. A conventional medicine has already been identified to repair the leaky bloodstreams that can be the major reason of the spreading of the cancer cells in the body. The clogging of nanoparticles immune cells can benefit them to pursue the cancerous cells in the bloodstream or it might reduce the chances of metastasis. In this research, the scientists have recognized a protein that can be a potential new medicine target for the prevention of metastasis. Calcium levels in the cells have long been known to be regulated, but the team has now found that a protein has another function that can contribute to metastasis.
Fascinatingly, healthy cells have shown a much higher TRPM7 than tumor cells, which explains why its spread is more rapid. The scientists tested the cells discovered by the movement of a bloodstream model of ladder-like microchannels, which controlled the flow very carefully. They also found that the healthy fibroblastic cells in response to fluid flow in reverse directions and moved to channels that still contain liquid. Although the finding is still very early, this study showing the prevention the metastasis of cancer by targeting TRPM7 protein could open up the ways for effective treatment.
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