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replication is the biological process of producing two identical replicas of
DNA from one original DNA molecule. DNA replication occurs in all living
organisms acting as the basis for biological inheritance.
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polymerase is an enzyme that synthesizes DNA molecules from
deoxyribonucleotides, the building blocks of DNA. These enzymes are essential
for DNA replication and usually work in pairs to create two identical DNA
strands from a single original DNA molecule.
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binding proteins are a class of proteins that have been identified in both
viruses and organisms from bacteria to humans.
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are enzymes that participate in the overwinding or underwinding of DNA. The
winding problem of DNA arises due to the intertwined nature of its
double-helical structure. During DNA replication and transcription, DNA becomes
overwound ahead of a replication fork.
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ligase is a specific type of enzyme, a ligase, that facilitates the joining of
DNA strands together by catalyzing the formation of a phosphodiester bond. It
plays a role in repairing single-strand breaks in duplex DNA in living
organisms, but some forms may specifically repair double-strand breaks.
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replication fork is a very active area where DNA replication takes place. It is
created when DNA helicase unwinds the double helix structure of the DNA. The
replication fork looks like a fork in the road that is composed of a leading
strand and a lagging strand of DNA.
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lagging strand is one of two strands of DNA found at the replication fork, or
junction, in the double helix; the other strand is called the leading strand. A
lagging strand requires a slight delay before undergoing replication, and it
must undergo replication discontinuously in small fragments.
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fragments are short sequences of DNA nucleotides which are synthesized
discontinuously and later linked together by the enzyme DNA ligase to create
the lagging strand during DNA replication.
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linear chromosome is a type of chromosome, found in most eukaryotic cells, in
which the DNA is arranged in multiple linear molecules of DNA. In contrast,
most prokaryotic cells contain circular chromosomes, where the DNA is arranged
in one large circular molecule.
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telomere is a region of repetitive nucleotide sequences at each end of a
chromosome, which protects the end of the chromosome from deterioration or from
fusion with neighboring chromosomes. Its name is derived from the Greek nouns
telos “end” and merοs “part”.
is a reverse transcriptase- it copies a RNA to put the repeated sequence on the
ends of linear chromosomes
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repair is a collection of processes by which a cell identifies and corrects
damage to the DNA molecules that encode its genome.