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Since 1963, biologists of the Denver Wildlife Research Center have been investigating methods of alleviating agricultural damage by the black-tailed jackrabbit (Lepus californicus). Of the several approaches to control, most biological methods (predation, habitat manipulation, disease and parasites, and chemosterilants) appear impractical with present knowledge. Mechanical control except for fence barriers, usually has limited effectiveness. Currently, the most useful approach is still chemical control. Improved baiting techniques and several chemical control agents, including an experimental toxicant highly selective for jackrabbits, are described.