Pseudomonas aeruginosa is perhaps best known for its ability to become resistent to antibiotics. This process has been faster than our ability to respond with new antibiotics for decades. After a quick glance over the infections caused by P. aeruginosa and over resistance data for Estonia, the review focuses on antibiotic resistance mechanisms, their relevance and new solutions. Some new treatments have been introduced to clinical practice or are currently applicable if needed (diagnostics, dosing regimens, drug combinations, nonfarmacological treatments). Many more Technologies await in the laboratory for further testing but some have reached clinical stages. These studies are brief ly discussed.