A conditionally essential amino acid is one that can usually be synthesized by the human body. However, under certain conditions like illness or stress the body might not be able, or might be limited in the ability, to synthesize them.
For most amino acid supplements, it is probably best to take them on an empty stomach. Avoid taking any amino acid supplement with food or drink that contains protein. The protein might interfere with the absorption of the amino acids.
Conditionally Essential Amino Acids:
Arginine can usually be synthesized by the human body under normal conditions but preterm infants can not produce arginine internally. For them, arginine is an essential amino acid. This makes supplementation necessary. More about arginine here.
Cysteine can normally be synthesized in the bodies of healthy individuals if there is enough methionine available, but infants, the elderly, those with certain metabolic diseases, or those with malabsorption syndromes may not be able to and require supplements. More information about cysteine is here.
Glutamine can usually be synthesized by the human body under normal conditions but during catabolic states of illness and injury, an individual may require getting glutamine from food or supplements. More information about glutamine is here.
Glycine supplementation can be beneficial for those suffering from illnesses or recovering from injury or surgery. Some medications and stress may limit the amount of glycine the body can produce. More information about glycine is found here.
Proline can usually be produced by the human body under normal conditions by synthesizing it from glutamate. However, in times of illness and stress the body might not be able to produce it and it must be obtained from food or supplements. More information about proline is here.
Serine deficiency is a rare but can result from problems in the biosynthesis of serine. It is an inherited metabolic disorder that may result in severe mental problems. Those with serine deficiency may respond to treatment with oral serine supplements. More info about serine is here.
Tyrosine can normally be synthesized from phenylalanine but the bodies of people with Phenylketonuria (PKU) are not able to, so it must be supplemented. Also those who do not get enough phenylalanine may require tyrosine. More tyrosine info is here.