Παχυσαρκία και υπογονιμότητα (Master thesis)
Obesity is now an epidemic that increasingly concerns the scientific community. 50% of the population worldwide and 7 in 10 Greeks are obese. Energy imbalance in obesity affects the function of the reproductive axis. The exact mechanism is unclear. Peripheral aromatization of androgens, hyperinsulinemia, insulin resistance, hyperandrogenism, alterations in antipokines and ghrelin play an important role. In obese women are observed menstrual irregularities, anovulation and more prevalent adverse effects of PCOS. The low quality of oocytes they produce, leading to poor quality embryos. The reduced endometrial receptivity leads to increased rates of miscarriages. Also, obesity adversely affects male fertility causing hormonal changes, sexual dysfunction and changes in sperm parameters. Obese women who resort to Assisted Reproductive Technology do not have the same success rates compared with women of normal weight. Larger doses of drugs are administered, less number of oocytes is obtained and smaller proportions of embryos are cryopreserved. It is observed increased cancellation rate, increased failure to achieve clinical intrauterine pregnancy and live births. The impact of increased BMI is higher in women <35 years, whereas in women >35 years age is the main aggravating factor in achieving pregnancy. First-line treatment is weight reduction through lifestyle modification by diet and exercise. Complementary medication is indicated when the above measures considered inadequate or fail. Finally, bariatric surgery is indicated in patients with morbid obesity and it is the most effective treatment for weight loss.
|Institution and School/Department of submitter:||Δημοκρίτειο Πανεπιστήμιο Θράκης. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Subject classification:||Human reproduction|
|Keywords:||Παχυσαρκία,Υπογονιμότητα,Αναπαραγωγή,Μέθοδοι υποβοηθούμενης αναπαραγωγής,Obesity,Infertility,Reproduction,Reproductive technology|
|Appears in Collections:||Π.Μ.Σ. ΑΝΘΡΩΠΙΝΗ ΑΝΑΠΑΡΑΓΩΓΗ|
Files in This Item:
|SiskouM_2016.pdf||Μεταπτυχιακή εργασία||684.22 kB||Adobe PDF||View/Open|
Please use this identifier to cite or link to this item:This item is a favorite for 0 people.
This item is licensed under a Creative Commons License