Host-Defense Activities of Cyclotides
AbstractCyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine knot arrangement of three conserved disulfide bonds. This article provides an overview of the reported pesticidal or toxic activities of cyclotides, discusses a possible common mechanism of action involving disruption of biological membranes in pest species, and describes methods that can be used to produce cyclotides for potential applications as novel pesticidal agents. View Full-Text
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Craik, D.J. Host-Defense Activities of Cyclotides. Toxins 2012, 4, 139-156.
Craik DJ. Host-Defense Activities of Cyclotides. Toxins. 2012; 4(2):139-156.Chicago/Turabian Style
Craik, David J. 2012. "Host-Defense Activities of Cyclotides." Toxins 4, no. 2: 139-156.