The SARS-CoV-2 is really a novel member of coronavirus family. Coronavirus are enveloped positive sense single strand RNA viruses (genome size 36C42?kb, diameter: 60C140?nm) having surface projections resembling a crown under the electron microscope. This crown like appearance is the basis behind the name, Coronavirus. These viruses are zoonotic pathogens; they originate in wild animals and spill over from wildlife into humans causing disease. In the past 20?years, two members of the same family, the SARS-CoV and MERS-CoV possess caused epidemic outbreaks of Severe Acute Respiratory Symptoms (SARS) and Middle East Respiratory Symptoms (MERS) respectively. SARS-Cov-2 stocks 88% Goat monoclonal antibody to Goat antiMouse IgG HRP. hereditary similarity with SARS-CoV and 50% similarity with MERS-CoV . Over the last 4?a few months, several studies have already been published on COVID-19 which range from case-reports, case-series and good sized population studies which have reported the clinical features, lab results and diagnostic evaluation of people experiencing this disease. The main cause of loss of life is reported to become adult respiratory problems symptoms (ARDS) with periodic situations of multiorgan failing. Advancement in diagnostics via nucleic acidity testing played a significant role in discovering the sequences of viral genome. But there’s possibility of some extent of misdetection due to the sampling and over-hypersensitivity dependence. As the pathogen proceeds its wrath, the major concern may be the unavailability of any cure still. Just supportive treatment could be administered, thus urging the instant dependence on the development of effective preventive and therapeutic strategies. Rodriguez-Morales et al.  analysed 19 different studies in a meta-analysis and reported that fever, cough and dyspnoea were the most common manifestations among the 656 COVID-19 patients. Around 32.8% developed ARDS, 20.3% patients required critical care, and 6.2% developed shock. Fatal outcomes were seen in 13.9% patients. Later years was from the severity of the condition  significantly. Similar scientific manifestations were seen in another meta-analysis by Yang et al. including eight research with 46,248 contaminated sufferers and reported that hypertension, illnesses of respiratory and heart could be significant risk elements for intensity of COVID-19 . Later, Tipranavir these findings were supported by Emami et al. in another meta-analysis. After systematically analysing the data of 76,993 patients, smoking history and diabetes was added to the list  also. Only a little proportion from the infected patients progress to severe stage needing critical care. Hence, in lack of correct cure, it turns into necessary to delineate the elements that may assist in the severity evaluation of the condition. If individuals vulnerable to developing serious symptoms could be discovered early, administration of the condition may improve to a substantial level. In this framework, many research have got tried to establish the laboratory abnormalities that may aid in discriminating severe and non-severe instances. Among the laboratory guidelines, Guang et al. reported improved alanine transaminase (ALT), lactate dehydrogenase (LDH), D-dimer, C-Reactive Protein, ferritin along with significantly raised interleukins (IL-2R, IL-10, IL-6 and TNF-) in severe instances of COVID-19 in comparison to non-severe instances. A significantly lower complete number of lymphocytes, CD4+T and CD8+T cells along with downregulation of IFN- manifestation in severe instances was also observed . In another pre-print, Xiang et al. reported serum urea, creatinine and cystatin C may be potential biomarkers in severity of COVID-19 . Huang et al. reported higher plasma levels of interleukins (IL-2, IL-7, IL-10) along with other inflammatory markers (GSCF, IP10, MCP1, MIP1A and TNF-) in COVID-19 individuals requiring ICU care versus non-ICU individuals . Since the virus shares genetic similarity with SARS-CoV and MERS-CoV, researchers are expecting a similar molecular pathogenesis. Earlier studies have shown the event of a cytokine storm in SARS and MERS. Cytokine storm syndrome is a state of sudden surge of pro-inflammatory cytokines due to stimulation by drugs or pathogens that disrupts the normal balance of pro- and anti-inflammatory cytokines. Upon infection, the virus may abnormally activate various immune cells like dendritic cells, lymphocytes, natural killer cells and macrophages. Once activated, these cells produce high amounts of pro-inflammatory cytokines which further involves more immune cells leading to a positive feedback cycle. Upon crossing a certain threshold, this may lead to a cytokine storm characterised by aggravation of clinical symptoms along with diffuse intravascular coagulation, shock, multi-organ failure and death. It is now strongly believed that cytokine storm may lead to the transition from mild to severe in COVID-19 patients . If this link can be established, then existing interleukin blockers may be used for management of severe COVID-19 patients. There are several research questions still unanswered in relation to COVID-19. One of our interest is alternative diagnostic modalities. As of now, real time PCR based SARS-CoV-2 RNA detection from respiratory samples is the specific diagnostic test of COVID-19. But there are issues with sampling and other technicalities in this test. Recently, ELISA kits based on detection of IgM and IgG antibodies against N protein of SARS-CoV-2 have been made available . This has opened the possibility of diagnosing an ongoing as well as past infection. But there is a strong need to provide newer ELISA kits to detect viral antigens that may provide an alternative to viral RNA Tipranavir detection. Further, most of the research data in relation to COVID-19 has been obtained from studies in Chinese population. With the recent surge of infections in USA, Italy, Spain and other countries, data from these populations would add significant knowledge in understanding this disease. Thus, prospective studies should be planned to evaluate the pathogenesis, viral dynamics, the clinical and laboratory spectrum of the disease and to identify mechanistic changes that may aid in restorative strategies either by book get rid of or by medication repurposing. COVID-19 continues to be the largest public health problems state since Globe Battle II. It hasn’t limited itself like a medical crisis; it is influencing the global overall economy and if appropriate measures aren’t taken, it might possess serious implications in socio-economic position and lives of mankind daily. They have deeply challenged medical care facilities specifically in low- and middle-income countries. Every nationwide country is trying to safeguard its populations and medical workers as effectively as you possibly can. India provides applied countrywide lockdown since March 25 currently, 2020 using the eyesight to break the string of control and infections its transmitting. As the pathogen threatens community pass on, there’s an urgent have to improve facilities, develop novel tests facilities, prepare recruiting, support frontline wellness search and employees for a remedy before Tipranavir fight is won. Footnotes Publisher’s Note Springer Nature continues to be neutral in regards to to jurisdictional promises in published maps and institutional affiliations.. the cases of COVID-19 possess increased within the last 7 alarmingly?days. On March 28, 2020, the full total verified COVID-19 situations had been 775 with 19 fatalities. As on 04 April, 2020, this true number provides risen to 3127 confirmed cases and 86 deaths . The SARS-CoV-2 is really a novel person in coronavirus family members. Coronavirus are enveloped positive feeling one strand RNA infections (genome size 36C42?kb, size: 60C140?nm) having surface area projections resembling a crown beneath the electron microscope. This crown like appearance may be the basis behind the name, Coronavirus. These infections are zoonotic pathogens; they originate in wild animals and spill over from wildlife into humans causing disease. In the past 20?years, two users of the same family, the SARS-CoV and MERS-CoV have caused epidemic outbreaks of Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) respectively. SARS-Cov-2 shares 88% genetic similarity with SARS-CoV and 50% similarity with MERS-CoV . During the last 4?months, several studies have been published on COVID-19 ranging from case-reports, case-series and large population studies that have reported the clinical features, laboratory findings and diagnostic evaluation of individuals suffering from this disease. The major cause of death is reported to be adult respiratory distress syndrome (ARDS) with occasional cases of multiorgan failure. Advancement in diagnostics via nucleic acid testing played a major role in discovering the sequences of viral genome. But there’s probability of some extent of misdetection due to the over-hypersensitivity and sampling dependence. Because the trojan proceeds its wrath, the main concern continues to be the unavailability of any treat. Just supportive treatment could be implemented, thus urging the immediate need for the development of effective preventive and restorative strategies. Rodriguez-Morales et al.  analysed 19 different studies inside a meta-analysis and reported that fever, cough and dyspnoea were the most common manifestations among the 656 COVID-19 individuals. Around 32.8% developed ARDS, 20.3% individuals required critical care and attention, and 6.2% developed shock. Fatal outcomes were observed in 13.9% patients. Old age was significantly associated with the severity of the disease . Similar medical manifestations were observed in another meta-analysis by Yang et al. which included eight studies with 46,248 infected individuals and reported that hypertension, diseases of respiratory and cardiovascular system may be significant risk factors for severity of COVID-19 . Later on, these findings were supported by Emami et al. in another meta-analysis. After systematically analysing the data of 76,993 individuals, smoking history and diabetes was also added to the list . Only a small proportion of the infected individuals progress to severe stage needing crucial care. Therefore, in absence of appropriate cure, it becomes necessary to delineate the elements that may assist in the severity evaluation of the condition. If individuals vulnerable to developing serious symptoms could be discovered early, administration of the condition may improve to a substantial extent. Within this framework, several studies have got tried to determine the lab abnormalities that could assist in discriminating serious and non-severe situations. Among the lab variables, Guang et al. reported elevated alanine transaminase (ALT), lactate dehydrogenase (LDH), D-dimer, C-Reactive Proteins, ferritin alongside significantly elevated interleukins (IL-2R, IL-10, IL-6 and TNF-) in serious situations of COVID-19 compared to non-severe instances. A significantly lower absolute number of lymphocytes, CD4+T and CD8+T cells along with downregulation of IFN- manifestation in severe instances was also observed . In another pre-print,.