Einstein\'s famous equation E=mc2 asserts that energy and mass are different aspects of the same reality. It is usually associated with the idea that small amounts of mass can be converted into large amounts of energy. For fundamental physics, however, the more important idea is just the opposite. Researchers want to explain how mass itself arises, by explaining it in terms of more basic concepts. In this lecture targeted for a general audience, Prof. Wilczek will explain how this goal can, to a remarkable extent, be achieved. He will also discuss some of the consequences - an explanation of why gravity is so feeble - and suggestions for new physical phenomena at the Large Hadron Collider (LHC) in Geneva. Prof. Wilczek is a distinguished scientist and lecturer. He is the author of Fantastic Realities: 49 Mind Journeys and a trip to Stockholm and co-author of Longing for the Harmonies. In addition to many distinguished memberships and affiliations, he is a member of Perimeter Institutes Scientific Advisory Committee.