Genomes and Genes
Summary: Viruses parasitic on plants higher than bacteria.
Publications324 found, 100 shown here
- Cellular pathways for viral transport through plasmodesmataAnnette Niehl
Institut de Biologie Moleculaire des Plantes du CNRS, Universite de Strasbourg, 12 rue du Général Zimmer, 67084, Strasbourg, France
Protoplasma 248:75-99. 2011b>Plant viruses use plasmodesmata (PD) to spread infection between cells and systemically...
- Intracellular transport of plant viruses: finding the door out of the cellJames E Schoelz
Division of Plant Sciences, University of Missouri, Columbia, MO 65211, USA
Mol Plant 4:813-31. 2011b>Plant viruses are a class of plant pathogens that specialize in movement from cell to cell...
- Insect vector interactions with persistently transmitted virusesSaskia A Hogenhout
Department of Disease and Stress Biology, John Innes Centre, Norwich, NR4 7UH, United Kingdom
Annu Rev Phytopathol 46:327-59. 2008The majority of described plant viruses are transmitted by insects of the Hemipteroid assemblage that includes aphids, whiteflies, leafhoppers, planthoppers, and thrips...
- Virus-induced gene silencing in tomatoYule Liu
Department of Molecular, Cellular and Developmental Biology, OML 451, Yale University, PO Box 208104, New Haven, CT 06520 8104, USA
Plant J 31:777-86. 2002..Using this vector, we have silenced RbcS and an endogenous gene homologous to the tomato EST cLED3L14. In the future, this modified vector system will facilitate large-scale functional analysis of tomato ESTs...
- Cellular remodeling during plant virus infectionJean François Laliberté
INRS Institut Armand Frappier, Institut National de la Recherche Scientifique, Laval, Quebec, Canada H7V 1B7
Annu Rev Phytopathol 48:69-91. 2010..Confining the process of RNA replication to a specific location may also prevent the activation of certain host defense functions...
- Top 10 plant viruses in molecular plant pathologyKaren Beth G Scholthof
Department of Plant Pathology and Microbiology, 2132 TAMU, Texas A and M University, College Station, TX 77843 2132, USA
Mol Plant Pathol 12:938-54. 2011..scientists, if not all, feel that their particular plant virus should appear in any list of the most important plant viruses. However, to our knowledge, no such list exists...
- Behavioural aspects influencing plant virus transmission by homopteran insectsAlberto Fereres
Departamento de Proteccion Vegetal, Consejo Superior de Investigaciones Cientificas CSIC, Centro de Ciencias Medioambientales, Instituto de Ciencias Agrarias, Madrid, Spain
Virus Res 141:158-68. 2009..This review considers how vector behaviour influences the transmission and spread of plant viruses depending on the type of virus-vector relationship...
- Varied movement strategies employed by triple gene block-encoding virusesJeanmarie Verchot-Lubicz
Oklahoma State University, Department of Entomology and Plant Pathology, Stillwater, OK 74078, USA
Mol Plant Microbe Interact 23:1231-47. 2010..We also suggest areas that might profit from future research on viruses harboring this intriguing arrangement of movement proteins...
- Triple gene block: modular design of a multifunctional machine for plant virus movementSergey Yu Morozov
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
J Gen Virol 84:1351-66. 2003..data obtained on both the TGB and well-studied single protein transport systems clearly demonstrate that plant viruses employ host cell pathways for intra- and intercellular trafficking of genomic nucleic acids and proteins, ..
- Hierarchical action and inhibition of plant Dicer-like proteins in antiviral defenseAngelique Deleris
Institut de Biologie Moleculaire des Plantes, CNRS Unité Propre de Recherche UPR 2357, 12, rue du Général Zimmer, 67084 Strasbourg Cedex, France
Science 313:68-71. 2006..These findings define a molecular framework for studying antiviral silencing and defense in plants...
- 3' Cap-independent translation enhancers of positive-strand RNA plant virusesBeth L Nicholson
Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3
Curr Opin Virol 1:373-80. 2011Positive-strand RNA plant viruses that are neither 5'-capped nor 3'-polyadenylated use nontraditional mechanisms to recruit ribosomes to the 5'-end of their viral genomes...
- Next-generation sequencing and metagenomic analysis: a universal diagnostic tool in plant virologyIan P Adams
Central Science Laboratory, Sand Hutton, York, UK
Mol Plant Pathol 10:537-45. 2009..This method expedites the entire process of novel virus discovery, identification, viral genome sequencing and, subsequently, the development of more routine assays for new viral pathogens...
- A systems biology approach to the evolution of plant-virus interactionsSantiago F Elena
Instituto de Biologia Molecular y Celular de Plantas, CSIC UPV, Ingeniero Fausto Elio s n, 46022 Valencia, Spain
Curr Opin Plant Biol 14:372-7. 2011..Here, we review studies identifying host genes regulated by viruses and discuss how these genes integrate in host regulatory and interaction networks, with a particular focus on the physical properties of these networks...
- Differing requirements for actin and myosin by plant viruses for sustained intercellular movementPhillip A Harries
Plant Biology Division, The Samuel Roberts Noble Foundation, Inc 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
Proc Natl Acad Sci U S A 106:17594-9. 2009..the importance of microfilaments and myosins for the sustained intercellular movement of a group of RNA-based plant viruses. We demonstrate that the intercellular movement of viruses from different genera [tobacco mosaic virus (TMV), ..
- Plant viruses spread by diffusion on ER-associated movement-protein-rafts through plasmodesmata gated by viral induced host beta-1,3-glucanasesBernard L Epel
Department of Plant Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Semin Cell Dev Biol 20:1074-81. 2009b>Plant viruses spread cell-to-cell by exploiting and modifying plasmodesmata, coaxial membranous channels that cross cell walls and interlink the cytoplasm, endoplasmic reticulum and plasma-membranes of contiguous cells...
- Broad spectrum resistance to ssDNA viruses associated with transgene-induced gene silencing in cassavaPadmanabhan Chellappan
Danforth Plant Science Center, 975 N Warson Rd, St Louis, MO, 63132, USA
Plant Mol Biol 56:601-11. 2004..The robust cross-resistance reported has important implications for field deployment of transgenic strategies to control geminiviruses...
- How do plant viruses induce disease? Interactions and interference with host componentsVicente Pallas
Instituto de Biología Molecular y Celular de las Plantas, CSIC Universidad Politecnica de Valencia, Avenida de los Naranjos s n, 46022 Valencia, Spain
J Gen Virol 92:2691-705. 2011b>Plant viruses are biotrophic pathogens that need living tissue for their multiplication and thus, in the infection-defence equilibrium, they do not normally cause plant death...
- Translation initiation factors: a weak link in plant RNA virus infectionChristophe Robaglia
Laboratoire de Genetique et Biophysique des Plantes, CEA CNRS Université Aix Marseille II, Faculte des Sciences de Luminy, F 13009 Marseille, France
Trends Plant Sci 11:40-5. 2006Recessive resistance genes against plant viruses have been recognized for a long time but their molecular nature has only recently been linked to components of the eukaryotic translation initiation complex...
- Codon usage bias amongst plant virusesM J Adams
Plant Pathogen Interactions Division, Rothamsted Research, Harpenden, Herts, UK
Arch Virol 149:113-35. 2004..Mutational bias, rather than translational selection appears to account for the majority of the variation detected. The software is available at http://www.dpvweb.net/analysis/codons.php...
- Selection pressures in the capsid genes of plant RNA viruses reflect mode of transmissionElizabeth R Chare
Department of Zoology, Tinbergen Building, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
J Gen Virol 85:3149-57. 2004..This analysis provided strong evidence that the capsid proteins of vector-borne plant viruses are subject to greater purifying selection on amino acid change than those viruses transmitted by other routes ..
- Insect transmission of plant viruses: a constraint on virus variabilityA G Power
Department of Ecology and Evolutionary Biology, Corson Hall, Cornell University, Ithaca 14853, USA
Curr Opin Plant Biol 3:336-40. 2000..Recent studies of insect-transmitted plant viruses demonstrate highly conserved molecular motifs in viral genomes that regulate the specificity of insect ..
- A multipartite single-stranded negative-sense RNA virus is the putative agent of fig mosaic diseaseToufic Elbeaino
Istituto Agronomico Mediterraneo di Bari, Via Ceglie 9, 70010 Valenzano, Italy
J Gen Virol 90:1281-8. 2009..The consistent association of DMBs with mosaic symptoms and the results of molecular investigations strongly indicate that DMBs are particles of FMV, the aetiological agent of fig mosaic disease...
- Plant virus transport: motions of functional equivalenceHerman B Scholthof
Department of Plant Pathology and Microbiology, Texas A and M University, College Station, 77843, USA
Trends Plant Sci 10:376-82. 2005..In spite of all the different movement strategies and the viral and host components, there are possible functional commonalities in virus-host interactions that govern viral spread through plants...
- Deep sequencing analysis of viruses infecting grapevines: Virome of a vineyardBeatrix Coetzee
Department of Genetics, Stellenbosch University, Matieland, 7602, South Africa
Virology 400:157-63. 2010..The second most prevalent virus detected was a member of the Chrysoviridae family similar to Penicillium chrysogenum virus. Sequences aligning to two other mycoviruses were also detected...
- Cap-independent translation of plant viral RNAsElizabeth L Pettit Kneller
Interdepartmental Plant Physiology Program, Department of Plant Pathology, 351 Bessey Hall, Iowa State University, Ames, IA 50011, USA
Virus Res 119:63-75. 2006The RNAs of many plant viruses lack a 5' cap and must be translated by a cap-independent mechanism...
- Intracellular targeting of a hordeiviral membrane-spanning movement protein: sequence requirements and involvement of an unconventional mechanismMikhail V Schepetilnikov
Department of Botany and Plant Pathology, Oregon State University, Cordley Hall 2082, Corvallis, OR 97331, USA
J Virol 82:1284-93. 2008..The determinants of targeting to plasmodesmata were localized to the C-terminal region of TGBp3, including the conserved hydrophilic and terminal membrane-spanning domains...
- Domain organization of the N-terminal portion of hordeivirus movement protein TGBp1Valentin V Makarov
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119992, Russia
J Gen Virol 90:3022-32. 2009Three 'triple gene block' proteins known as TGBp1, TGBp2 and TGBp3 are required for cell-to-cell movement of plant viruses belonging to a number of genera including Hordeivirus...
- Plasmodesmata: gateways to local and systemic virus infectionYoselin Benitez-Alfonso
John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
Mol Plant Microbe Interact 23:1403-12. 2010..However, viral movement proteins provide valuable tools for the modification of plasmodesmata and will continue to assist in the dissection of plasmodesmal properties in relation to their core roles in cell-to-cell communication...
- Plasmodesmal targeting and intercellular movement of potato mop-top pomovirus is mediated by a membrane anchored tyrosine-based motif on the lumenal side of the endoplasmic reticulum and the C-terminal transmembrane domain in the TGB3 movement proteinJ Tilsner
Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, DD2 5DA, UK
Virology 402:41-51. 2010..Mutation of either of these domains also abolished cell-to-cell movement of the virus. The results are discussed in the context of TGB3 membrane topology...
- RNA helicase activity of the plant virus movement proteins encoded by the first gene of the triple gene blockN O Kalinina
Department of Virology, Moscow State University, Moscow, Russia
Virology 296:321-9. 2002Cell-to-cell and long-distance transport of some plant viruses requires coordinated action of three movement proteins encoded by triple gene block (TGB)...
- Involvement of the plant nucleolus in virus and viroid infections: parallels with animal pathosystemsM E Taliansky
Scottish Crop Research Institute, Invergowrie, Dundee, United Kingdom
Adv Virus Res 77:119-58. 2010..This chapter will highlight studies showing how plant viruses recruit nucleolar functions to facilitate virus translation and replication, virus movement and assembly of ..
- Recessive resistance to plant virusesV Truniger
Centro de Edafología y Biología Aplicada del Segura CEBAS, Consejo Superior de Investigaciones Cientificas CSIC, Apdo Correos 164, 30100 Espinardo Murcia, Spain
Adv Virus Res 75:119-59. 2009..We review actual and probable recessive resistance mechanisms, and bring the chapter to a close by summarizing the current state-of-the-art and offering perspectives on potential future developments...
- Virus-vector interactions mediating nonpersistent and semipersistent transmission of plant virusesJames C K Ng
Department of Plant Pathology, University of California, Riverside, California 92521, USA
Annu Rev Phytopathol 44:183-212. 2006Most plant viruses are absolutely dependent on a vector for plant-to-plant spread...
- Traffic of a viral movement protein complex to the highly curved tubules of the cortical endoplasmic reticulumShu Chuan Lee
Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan
Traffic 11:912-30. 2010Intracellular trafficking of the nonstructural movement proteins of plant viruses plays a crucial role in sequestering and targeting viral macromolecules in and between cells...
- Genetics of plant virus resistanceByoung Cheorl Kang
Department of Plant Breeding and Genetics, Cornell University, Ithaca, New York 14853, USA
Annu Rev Phytopathol 43:581-621. 2005Genetic resistance to plant viruses has been used for at least 80 years to control agricultural losses to viral diseases...
- An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAsNicolas Bouche
Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, INRA, Versailles, France
EMBO J 25:3347-56. 2006..Given the complexity of the small RNA repertoire in plants, the implication of each DCL, in particular DCL2, in the production of small RNAs that have no known function will constitute one of the next challenges...
- The N-terminal domain of PMTV TGB1 movement protein is required for nucleolar localization, microtubule association, and long-distance movementKathryn M Wright
Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
Mol Plant Microbe Interact 23:1486-97. 2010..The results suggest that PMTV TGB1 requires interaction with nuclear components and, possibly, microtubules for long-distance movement of viral RNA...
- Sequential recruitment of the endoplasmic reticulum and chloroplasts for plant potyvirus replicationTaiyun Wei
Southern Crop Protection and Food Research Centre, AAFC, 1391 Sandford Street, London, Ontario N5V 4T3, Canada
J Virol 84:799-809. 2010..Taken together, these results suggest that plant potyviruses sequentially recruit the ER and chloroplasts for their genome replication...
- Transient coexpression of individual genes encoded by the triple gene block of potato mop-top virus reveals requirements for TGBp1 traffickingAndrey A Zamyatnin
Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences SLU, SE 750 07 Uppsala, Sweden
Mol Plant Microbe Interact 17:921-30. 2004..The C-terminal region of TGBp1 was critical for trafficking mediated by TGBp2 and TGBp3. Mutation analysis also suggested an involvement of the TGBp2 C-terminal region in interactions with TGBp1...
- Two plant-viral movement proteins traffic in the endocytic recycling pathwaySophie Haupt
Programme of Cell to Cell Communication, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, United Kingdom
Plant Cell 17:164-81. 2005Many plant viruses exploit a conserved group of proteins known as the triple gene block (TGB) for cell-to-cell movement...
- The amazing diversity of cap-independent translation elements in the 3'-untranslated regions of plant viral RNAsW A Miller
Plant Pathology Department, 351 Bessey Hall, Iowa State University, Ames, IA 50011, USA
Biochem Soc Trans 35:1629-33. 2007..These results greatly expand our understanding of ways in which mRNAs can recruit ribosomes, and they provide insight into the regulation of virus gene expression...
- Virus adaptation by manipulation of host's gene expressionPatricia Agudelo-Romero
Instituto de Biologia Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas UPV, Valencia, Spain
PLoS ONE 3:e2397. 2008..A major difference is that genes involved in stress and pathogen response are not activated upon infection with the evolved virus, suggesting that selection has favored viral strategies to escape from host defenses...
- Geminivirus strain demarcation and nomenclatureC M Fauquet
Arch Virol 153:783-821. 2008..An updated list of all geminivirus isolates and a phylogenetic tree with one representative isolate per species are provided...
- Geminivirus AL2 and L2 proteins interact with and inactivate SNF1 kinaseLinhui Hao
Department of Molecular Genetics, Plant Biotechnology Center, The Ohio State University, Columbus, Ohio 43210, USA
Plant Cell 15:1034-48. 2003..They also indicate that geminiviruses are able to modify host metabolism to their own advantage, and they provide a molecular link between metabolic status and inherent susceptibility to viral pathogens...
- Nicotiana benthamiana: its history and future as a model for plant-pathogen interactionsMichael M Goodin
Department of Plant Pathology, University of Kentucky, Lexington 40546, USA
Mol Plant Microbe Interact 21:1015-26. 2008..is the most widely used experimental host in plant virology, due mainly to the large number of diverse plant viruses that can successfully infect it. Additionally, N...
- Plant viral movement proteins: agents for cell-to-cell trafficking of viral genomesWilliam J Lucas
Section of Plant Biology, College of Biological Sciences, University of California, One Shields Ave, Davis, CA 95616, USA
Virology 344:169-84. 2006..Pioneering studies on plant viruses revealed that PD allow the cell-to-cell trafficking of virally encoded proteins, termed the movement proteins (..
- Mechanisms of plant resistance to virusesJennifer L M Soosaar
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520 8103, USA
Nat Rev Microbiol 3:789-98. 2005..These pathways function in concert to result in effective protection against virus infection in plants...
- Evidence that a plant virus switched hosts to infect a vertebrate and then recombined with a vertebrate-infecting virusM J Gibbs
Bioinformatics, Research School of Biological Sciences, The Australian National University, G P O Box 475, Canberra 2601, Australia
Proc Natl Acad Sci U S A 96:8022-7. 1999..All characterized caliciviruses infect vertebrates, suggesting that the host-switch happened first and that the recombination took place in a vertebrate...
- The new plant virus family Flexiviridae and assessment of molecular criteria for species demarcationM J Adams
Plant Pathogen Interactions Division, Rothamsted Research, Harpenden, Herts, UK
Arch Virol 149:1045-60. 2004..Based on the distributions and on inspection of the data, it was concluded that, as a general rule, distinct species have less than ca. 72% identical nt or 80% identical aa between their entire CP or replication protein genes...
- Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencingTodd Blevins
Institute of Botany, University of Basel, Schönbeinstrasse 6, 4056 Basel, Switzerland
Nucleic Acids Res 34:6233-46. 2006..Our work highlights the complexity of virus interaction with host silencing pathways and suggests that DCL multiplicity helps mediate plant responses to diverse viral infections...
- Geminivirus disease complexes: an emerging threatShahid Mansoor
Plant Biotechnology Division, National Institute for Biotechnology and Genetic Engineering NIBGE, PO Box 577, Jhang Road, Faisalabad, Pakistan
Trends Plant Sci 8:128-34. 2003....
- Innovative tools for detection of plant pathogenic viruses and bacteriaMaria M Lopez
Instituto Valenciano de Investigaciones Agrarias, Apartado Oficial 46113, Moncada, Valencia, Spain
Int Microbiol 6:233-43. 2003....
- The cysteine-rich proteins of beet necrotic yellow vein virus and tobacco rattle virus contribute to efficient suppression of silencing in rootsIda Bagus Andika
Institute of Plant Science and Resources IPSR, Okayama University, Kurashiki 710 0046, Japan
J Gen Virol 93:1841-50. 2012Many plant viruses encode proteins that suppress RNA silencing, but little is known about the activity of silencing suppressors in roots...
- The expanding field of plant virus ecology: historical foundations, knowledge gaps, and research directionsCarolyn M Malmstrom
Department of Plant Biology, Michigan State University, East Lansing, MI, 48824 1312, USA
Virus Res 159:84-94. 2011b>Plant viruses are widespread in nature, where they operate in intimate association with their hosts and often with vectors...
- Viral diversity and prevalence gradients in North American Pacific Coast grasslandsEric W Seabloom
Oregon State University, Department of Zoology, 3029 Cordley Hall, Corvallis, Oregon 97330, USA
Ecology 91:721-32. 2010..This work demonstrates the need for further studies of processes governing coinfection, and the utility of applying theory developed to explain diversity in communities of free-living organisms to pathogen systems...
- A new eriophyid mite-borne membrane-enveloped virus-like complex isolated from plantsJoanna M Skare
Department of Plant Pathology and Microbiology, Texas A and M University, TX 77843, USA
Virology 347:343-53. 2006..Based on the collective properties, we conclude that HPD is caused by a newly emerged mite-borne virus, for which we propose the name Maize red stripe virus (MRStV)...
- RNA silencing pathways of plants: silencing and its suppression by plant DNA virusesThomas Hohn
Institute of Botany, University of Basel, Basel, Switzerland
Biochim Biophys Acta 1809:588-600. 2011..This article is part of a Special Issue entitled: MicroRNA's in viral gene regulation...
- Key determinants of resistance durability to plant viruses: insights from a model linking within- and between-host dynamicsFrederic Fabre
INRA, UR 407 Unité Pathologie Végétale, Montfavet, France
Virus Res 141:140-9. 2009..Finally, our analyses point out the parameters which should be estimated more precisely to improve durability predictions...
- Analysis of the spacing between the two palindromes of activation sequence-1 with respect to binding to different TGA factors and transcriptional activation potentialStefanie Krawczyk
Albrecht von Haller Institut fuer Pflanzenwissenschaften, Universitaet Goettingen, Untere Karspuele 2, 37073 Goettingen, Germany
Nucleic Acids Res 30:775-81. 2002..We therefore conclude that both DNA binding and transactivation require optimal positioning of TGA factors on the as-1 element...
- cDNA cloning and molecular characterization of cherry green ring mottle virusY P Zhang
Department of Plant Pathology, University of California, Davis 95616, USA
J Gen Virol 79:2275-81. 1998..A chimeric fusion coat protein was expressed in E. coli and antibodies specific for the CGRMV coat protein were raised in rabbits. The antibody was used in Western blot analyses to detect the CGRMV coat protein in infected cherry tissue...
- Formation of protein complexes containing plant virus movement protein TGBp3 is necessary for its intracellular traffickingElena A Shemyakina
Department of Virology, Biological Faculty, Moscow State University, Moscow, Russia
Biochimie 93:742-8. 2011..The C-terminal transmembrane segment is found to be an essential signal of TGBp3 intracellular transport to peripheral sites...
- Eukaryotic translation initiation factor 4E-mediated recessive resistance to plant viruses and its utility in crop improvementAiming Wang
Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, London, ON, Canada, N5V 4T3
Mol Plant Pathol 13:795-803. 2012..Interestingly, of the 14 natural recessive resistance genes against plant viruses that have been cloned from diverse plant species thus far, 12 encode the eukaryotic translation initiation ..
- New research horizons in vector-transmission of plant virusesStephane Blanc
UMR BGPI, INRA CIRAD SupAgro, CIRAD TA A54 K, Campus International de Baillarguet, 34398 Montpellier Cedex 05, France
Curr Opin Microbiol 14:483-91. 2011Understanding the mechanisms controlling vector-transmission of plant viruses requires integrating information from at least three different viewpoints: virus-vector interactions, plant-vector interactions and virus-plant interactions...
- The virulence-transmission trade-off in vector-borne plant viruses: a review of (non-)existing studiesR Froissart
Laboratoire Génétique and évolution des maladies infectieuses GEMI, UMR 2724 CNRS IRD, 911 Avenue Agropolis, 34394 Montpellier, France
Philos Trans R Soc Lond B Biol Sci 365:1907-18. 2010..what extent within-host viral accumulation determines the transmission rate and the virulence of vector-borne plant viruses. Studies suggest that the correlation between within-plant viral accumulation and transmission rate of natural ..
- Ecogenomics: using massively parallel pyrosequencing to understand virus ecologyMarilyn J Roossinck
The Samuel Roberts Noble Foundation, Ardmore, OK 73402, USA
Mol Ecol 19:81-8. 2010..this method we have been able to analyse thousands of plants, and we have discovered several thousand new plant viruses, all linked to their specific plant hosts...
- A comprehensive open reading frame phylogenetic analysis of isometric positive strand ssRNA plant virusesG W Stuart
Department of Life Sciences, Indiana State University, Terre Haute, Indiana 47809, USA
Arch Virol 151:1159-77. 2006..Using a set of 5 togaviruses as an outgroup, a comprehensive phylogeny for 115 isometric positive ssRNA plant viruses was generated based on the simultaneous comparison of over 480 ORFs found within completely sequenced genomes...
- Plant virus RNAs. Coordinated recruitment of conserved host functions by (+) ssRNA viruses during early infection eventsKarine Thivierge
Department of Plant Science, McGill University, Ste Anne de Bellevue, Canada H9X 3V9
Plant Physiol 138:1822-7. 2005....
- Symbiosis versus competition in plant virus evolutionMarilyn J Roossinck
The Samuel Roberts Noble Foundation, Plant Biology Division, Ardmore, Oklahoma 73401, USA
Nat Rev Microbiol 3:917-24. 2005..In this review, the evolution of plant viruses has been reinterpreted in light of these two seemingly opposing theories by using evidence from the earliest ..
- Raspberry leaf blotch virus, a putative new member of the genus Emaravirus, encodes a novel genomic RNAWendy J McGavin
Cell and Molecular Sciences Group, The James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK
J Gen Virol 93:430-7. 2012..The amino acid sequence of the P5 protein does not suggest any potential function; however, when expressed as a GFP fusion, it localized as small aggregates in the cytoplasm near to the periphery of the cell...
- Facilitative and antagonistic interactions between plant viruses in mixed infectionsJerzy Syller
Plant Breeding and Acclimatization Institute National Research Institute, Centre Młochów, 05 831 Młochów, Poland
Mol Plant Pathol 13:204-16. 2012Mixed infections of plant viruses are common in nature, and a number of important virus diseases of plants are the outcomes of interactions between causative agents...
- Use of multiline cultivars and cultivar mixtures for disease managementC C Mundt
Department of Botany and Plant Pathology, Oregon State University, Corvallis 97331 2902, USA
Annu Rev Phytopathol 40:381-410. 2002..Practical difficulties associated with mixtures have often been overestimated, however, and mixtures will likely play an increasingly important role as we develop more sustainable agricultural systems...
- Characterization of a virus infecting Citrus volkameriana with citrus leprosis-like symptomsMichael J Melzer
University of Hawaii, Honolulu, HI, USA
Phytopathology 102:122-7. 2012..arnottianus and were >98% identical to the RNAs isolated from C. volkameriana. We contend that the virus described in this study is HGSV, and propose that it be the type member of a new virus genus, Higrevirus...
- The coevolution of plants and viruses: resistance and pathogenicityAurora Fraile
Centro de Biotecnología y Genómica de Plantas UPM INIA and E T S I Agrónomos, Universidad Politecnica de Madrid, Campus de Montegancedo, Pozuelo de Alarcon, Madrid, Spain
Adv Virus Res 76:1-32. 2010..Here, we review evidence supporting plant-virus coevolution and point to areas in need of attention to understand the role of viruses in plant ecosystem dynamics, and the factors that determine virus emergence in crops...
- The hrpZ gene of Pseudomonas syringae pv. phaseolicola enhances resistance to rhizomania disease in transgenic Nicotiana benthamiana and sugar beetOurania I Pavli
Department of Crop Sciences, Agricultural University of Athens, Athens, Greece
PLoS ONE 6:e17306. 2011..Possible molecular mechanisms underlying the enhanced resistance and plant growth phenotypes observed in SP/HrpZ transgenic plants are discussed...
- Local context drives infection of grasses by vector-borne generalist virusesElizabeth T Borer
Department of Ecology, Evolution, and Behavior, University of Minnesota, St Paul, MN 55108, USA
Ecol Lett 13:810-8. 2010..For B/CYDV, local context more strongly predicts infection risk than host species traits or regional context; such spatially nested experiments can clarify the factors underlying variation in infection risk...
- Nucleo-cytoplasmic shuttling of the beet necrotic yellow vein virus RNA-3-encoded p25 proteinGuillaume Vetter
Departement de Virologie, Institut de Biologie Moleculaire des Plantes du CNRS, 12 rue du Général Zimmer, 67084 Strasbourg, France
J Gen Virol 85:2459-69. 2004..Studies with mutated derivatives of GFP-p25 revealed that symptom phenotype was altered when the subcellular localization of GFP-p25 was modified...
- Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analysesEugenie Hebrard
UMR 1097 Résistance des Plantes aux Bio agresseurs, IRD, CIRAD, Universite de Montpellier II, BP 64501, 34394 Montpellier Cedex 5, France
Virol J 6:23. 2009..To date, structural data are still limited to small picornaviral VPgs. Recently three phytoviral VPgs were shown to be natively unfolded proteins...
- Synergism of the 3'-untranslated region and an internal ribosome entry site differentially enhances the translation of a plant virus coat proteinDora Chin Yen Koh
Department of Biological Sciences, The National University of Singapore, 14 Science Dr 4, Singapore 117543
J Biol Chem 278:20565-73. 2003..To our knowledge, this is the first report describing a mechanism whereby an IRES, located in the 3' portion of the virus genome, co-operates with the 3'-UTR to enhance gene expression differentially...
- The adaptation of Rice yellow mottle virus to the eIF(iso)4G-mediated rice resistanceOumar Traore
Institut de l Environnement et de Recherches Agricoles, Ouagadougou, Burkina Faso
Virology 408:103-8. 2010..Comparison with the RB process of rymv1-2, a resistance allele found in a few Oryza sativa cultivars, showed similarities in the mode of adaptation but revealed converse virulence specificity of the isolates...
- Tobacco rattle virus mediates gene silencing in a plant parasitic root-knot nematodeG Dubreuil
INRA UNSA CNRS, UMR 1064, Interactions Plantes Microorganismes et Santé Végétale, 400, Route des Chappes, BP 167, F 06903 Sophia Antipolis, France
J Exp Bot 60:4041-50. 2009..However, the heterogeneity in RNAi efficiency between TRV-inoculated plants appears as a limitation to the use of TRV-mediated silencing for the high-throughput functional analysis of the targeted nematode genes...
- Localization of Poa semilatent virus cysteine-rich protein in peroxisomes is dispensable for its ability to suppress RNA silencingN E Yelina
AN Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119899, Russia
J Gen Virol 86:479-89. 2005..These data indicate that gammab functions are not associated with the protein's localization to peroxisomes...
- Arabidopsis synaptotagmin SYTA regulates endocytosis and virus movement protein cell-to-cell transportJennifer D Lewis
Department of Plant Pathology and Plant Microbe Biology, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 107:2491-6. 2010..Our studies show that SYTA regulates endocytosis, and suggest that distinct virus movement proteins transport their cargos to plasmodesmata for cell-to-cell spread via an endocytic recycling pathway...
- A minimal region in the NTPase/helicase domain of the TGBp1 plant virus movement protein is responsible for ATPase activity and cooperative RNA bindingAnna D Leshchiner
A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119992, Russia
J Gen Virol 87:3087-95. 2006....
- Triple gene block protein interactions involved in movement of Barley stripe mosaic virusHyoun Sub Lim
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
J Virol 82:4991-5006. 2008..These experiments suggest that BSMV movement requires physical interactions of TGB2 and TGB3 and that substantial deviation from the TGB protein ratios expressed by the wild-type virus compromises movement...
- Intracellular transport of viruses and their components: utilizing the cytoskeleton and membrane highwaysPhillip A Harries
Department of Biology, Pittsburg State University, Pittsburg, KS 66762, USA
Mol Plant Microbe Interact 23:1381-93. 2010b>Plant viruses are obligate organisms that require host components for movement within and between cells...
- A protein key to plant virus transmission at the tip of the insect vector styletMarilyne Uzest
Unite Mixte de Recherche, Biologie et Génétique des Interactions Plante Parasite, Institut National de la Recherche Agronomique, Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement, AGRO Montpellier, Montpellier, France
Proc Natl Acad Sci U S A 104:17959-64. 2007Hundreds of species of plant viruses, many of them economically important, are transmitted by noncirculative vector transmission (acquisition by attachment of virions to vector mouthparts and inoculation by subsequent release), but virus ..
- Virgaviridae: a new family of rod-shaped plant virusesMichael J Adams
Department of Plant Pathology and Microbiology, Rothamsted Research, Hertfordshire, UK
Arch Virol 154:1967-72. 2009..The chief characteristics of members of the family are presented with phylogenetic analyses of selected genes to support the creation of the family. Species demarcation criteria within the genera are examined and discussed...
- Subcellular sorting of small membrane-associated triple gene block proteins: TGBp3-assisted targeting of TGBp2A G Solovyev
Department of Virology, Moscow State University, Moscow, 119899, Russia
Virology 269:113-27. 2000..This conclusion was further confirmed by similar effects on the PSLV 15K TGBp2 localization induced by TGBp3 proteins of PSLV and potato virus X, which have no detectable sequence similarity to each other...
- Emerging viral diseases of tomato cropsInge M Hanssen
Scientia Terrae Research Institute, Sint Katelijne Waver, Belgium
Mol Plant Microbe Interact 23:539-48. 2010..In this article, emerging viruses of tomato crops are discussed...
- Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate stepElisabeth J Chapman
Department of Botany and Plant Pathology, and Center for Gene Research and Biotechnology, Oregon State University, Corvallis, Oregon 97331, USA
Genes Dev 18:1179-86. 2004RNA silencing suppressors from different plant viruses are structurally diverse...
- Subcellular localisation, protein interactions, and RNA binding of Potato mop-top virus triple gene block proteinsG H Cowan
Scottish Crop Research Institute, Invergowrie, By Dundee, DD2 5DA, Scotland, United Kingdom
Virology 298:106-15. 2002..However, the process is facilitated by RNA-protein rather than protein:protein interactions between the TGBp1 in complex with viral RNA and membrane-localised TGBp2...
- Effects and side-effects of viral RNA silencing suppressors on short RNAsDániel Silhavy
Agricultural Biotechnology Center, Plant Biology, PO Box 411, H 2101, Godollo, Hungary
Trends Plant Sci 9:76-83. 2004..To counteract an antiviral RNA silencing response, plant viruses express silencing suppressor proteins...
- Use of viral vectors for vaccine production in plantsM Carmen Cañizares
John Innes Centre, Norwich, UK
Immunol Cell Biol 83:263-70. 2005..In this review, we discuss advances made in this field...
- Experimental evolution of plant RNA virusesS F Elena
Instituto de Biologia Molecular y Celular de Plantas, CSIC UPV, Valencia, Spain
Heredity (Edinb) 100:478-83. 2008..However, plant viruses provide almost identical advantages for evolutionary studies and, in addition, offer an invaluable tool for ..
- Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of microrna in host gene expressionJun Chen
Institute of Molecular and Cell Biology, National University of Singapore, Singapore 117609
Plant Cell 16:1302-13. 2004..Because p69-expressing plants exhibited disease-like symptoms in the absence of viral infection, our findings suggest a novel mechanism for viral virulence by promoting the miRNA-guided inhibition of host gene expression...
- Antagonistic effects of soybean viruses on soybean aphid performanceJack R Donaldson
Department of Entomology, University of Wisconsin, Madison, WI 53706, USA
Environ Entomol 36:918-25. 2007..Mastumura, a recently introduced pest of soybean in the upper midwestern United States, and a complex of plant viruses vectored to soybean by insects have become a major concern for growers in the region...
- An anchored linkage map for sugar beet based on AFLP, SNP and RAPD markers and QTL mapping of a new source of resistance to Beet necrotic yellow vein virusM K Grimmer
Broom s Barn Research Station, Higham, Bury St Edmunds, IP28 6NP, UK
Theor Appl Genet 114:1151-60. 2007..The availability to breeders of new resistance sources such as Rz4 increases the potential for breeding durable disease resistance...
- Plant and animal rhabdovirus host range: a bug's viewSaskia A Hogenhout
Department of Entomology, 120 Thorne Hall, The Ohio State University OARDC, 1680 Madison Avenue, Wooster, OH 44691, USA
Trends Microbiol 11:264-71. 2003....
- Delivery of macromolecules to plant parasitic nematodes using a tobacco rattle virus vectorTracy A Valentine
Scottish Crop Research Institute, Invergowrie, Dundee, Scotland DD2 5DA, UK
Plant Biotechnol J 5:827-34. 2007..We show also that TRV vectors expressing nematode gene sequences can be used to induce RNAi in the feeding nematodes...
- Distinct expression of endogenous Petunia vein clearing virus and the DNA transposon dTph1 in two Petunia hybrida lines is correlated with differences in histone modification and siRNA productionFaiza Noreen
Friedrich Miescher Institute, Maulbeerstlasse 66, CH 4058 Basel, Switzerland
Plant J 50:219-29. 2007..The predominant association of ePVCV sequences with histone H3 methylated at lysine 9 (H3mK9) in RdC and with about equal amounts of H3mK9 and H3mK4 in W138 indicates a less repressive proviral state in the latter cultivar...
- Evidence that RNA silencing-mediated resistance to beet necrotic yellow vein virus is less effective in roots than in leavesIda Bagus Andika
Research Institute for Bioresources, Okayama University, Kurashiki, Okayama 710 0046, Japan
Mol Plant Microbe Interact 18:194-204. 2005..These results indicate that the RNA silencing-mediated resistance to BNYVV is less effective in roots than in leaves...
- Molecular Biology of Eukaryotic VirusesBert L Semler; Fiscal Year: 2012..Ty3, poliovirus, human rhinovirus, coxsackievirus, mouse hepatitis virus, SARS coronavirus, arenaviruses, herpes simplex virus, Epstein-Barr virus, human papillomavirus, vaccinia virus, and a number of RNA-containing plant viruses.
- Mechanisms of Virus Replication and Gene ExpressionANNE ELIZABETH SIMON; Fiscal Year: 2013..West Nile, caliciviruses, as well as prions, viroids, fungal hypoviruses, and the model plant viruses Tobacco mosaic virus and Turnip crinkle virus...
- Molecular probes for a vOTU from CCHFV using a fluorogenic peptideSCOTT DUSAN PEGAN; Fiscal Year: 2013..Even plant viruses such as the damaging rice stripe virus have been shown to possess a viral ovarian tumor domain protease ..
- Analyses of two RNA helicases that affect intercellular transport via plasmodesmaPatricia C Zambryski; Fiscal Year: 2012..As PD are essential gatekeepers for cell-to-cell transport during development and for the spread of plant viruses and gene silencing signals, our studies will enhance our understanding of how PD control complex developmental ..
- Control of cap-independent translation by a viral 3'UTRWYATT ALLEN MILLER; Fiscal Year: 2013..Although this work focuses on model plant viruses, many growing human viruses such as dengue and hepatitis C viruses use similar mechanisms...
- Structure and function of icosahedral virusesMichael G Rossmann; Fiscal Year: 2013..With the attainment of this goal some eight years later, attention shifted from plant viruses to the greater challenge of animal viruses...
- Molecular biology of viral capsidsCHENG C KAO; Fiscal Year: 2013..The latter set of observations led to the hypothesis that plant viruses gain entry into cells through a protein transduction mechanism...
- Control of Macromolecular Traffic Through PlasmodesmataVITALY H CITOVSKY; Fiscal Year: 2013..Whereas both mammalian and plant pathogens, e.g., prions and (potentially) HIV as well as most plant viruses, utilize cell-to-cell transport pathways, the first such capability was identified for plant viruses...
- Research Training in Comparative Viral PathogenesisCharles Wood; Fiscal Year: 2013..This highly successful program is unique because it boasts research strengths in human, animal, and plant viruses, and its research experiences are comparative in nature, an emphasis not available at other institutions...
- TRAINING IN MOLECULAR VIROLOGY AND PATHOGENESISColin R Parrish; Fiscal Year: 2010..cell replication mechanisms, retrovirus capsid assembly, baculovirus replication, and the interactions between plant viruses and their host cell transport pathways...
- Nebraska Center for VirologyCharles Wood; Fiscal Year: 2011..NCV investigators study human, animal, and plant viruses;their collective expertise presents a national strength and an exceptional opportunity to collaborate on model ..
- Nebraska Center for VirologyCharles Wood; Fiscal Year: 2013..NCV investigators study human, animal, and plant viruses;their collective expertise presents a national strength and an exceptional opportunity to collaborate on model ..
- STRUCTURE OF VIRAL RNA IN RIBOSOMAL FRAMESHIFTINGAlexander Rich; Fiscal Year: 2004..The -1 frameshifting is not only found in retroviruses, but also found in coronaviruses, yeast and plant viruses, as well as bacterial systems...
- REGULATION OF PROTEIN TOBACCO MOSAIC VIRUS RNA COMPLEXESVitaly Citovsky; Fiscal Year: 2002..connections, termed gap Cell-to-cell translocation of tobacco mosaic virus (TMV), one of the best studied plant viruses, is mediated by its movement protein (MP), proposed to form complexes with the genomic TMV RNA and target them ..
- CONFERENCE ON POSITIVE-STRAND RNA VIRUSESMARGO BRINTON; Fiscal Year: 1992..At least seven families of animal viruses, the majority of the plant viruses, one family of insect viruses and one family of bacteriophages are of this type...
- Silencing Suppression Mechanism of a Herpes Simplex Virus Virion ComponentNIL CELEBI CHERUKURI; Fiscal Year: 2009..In an effort to overcome RNA silencing, plant viruses encode RNA silencing suppressor proteins...
- CONFERENCE ON POSITIVE-STRAND RNA VIRUSESMARGO BRINTON; Fiscal Year: 2001..Positive-strand RNA viruses comprise seven families of animal viruses, eighteen families of plant viruses, one family of insect viruses and one family of bacteriophages...
- HOST PROTEINS REQUIRED FOR GEMINIVIRUS INFECTIONIAN PETTY; Fiscal Year: 2000..viruses, little is known about the molecular interactions which determine the host-adaptation of plant viruses. This proposal focuses on geminiviruses, which are plant-infecting viruses with small DNA genomes...
- PLANT VIRUS CHIMERAS AS VACCINES AND ANTIVIRALSMarianne Manchester; Fiscal Year: 2003..Plant virus particles provide an excellent means to combat this problem. Plant viruses are inexpensive, stable, and easy to produce in large quantities...
- Hsp70 as Dispatcher of Virus Assembly and TraffickingVALERIAN DOLJA; Fiscal Year: 2007Infection cycles of the human, animal, and plant viruses include processes of virion assembly and dissemination within the infected organism...
- STRUCTURE AND ASSEMBLY OF HELICAL PLANT VIRUSESGerald Stubbs; Fiscal Year: 1991..We plan to improve the quality of our TRV diffraction patterns, by varying the solution conditions under which specimens for X- ray diffraction experiments are made...
- Plant Viruses as Platforms for BiomaterialsJohn Johnson; Fiscal Year: 2006Many icosahedral and helical plant viruses produce at high levels in susceptible hosts, with yields in excess of 1 gram/Kg of leaves being common...
- Mapping the sgRNA2 and sgRNA3 Promoters of BYDVJACQUELYN JACKSON; Fiscal Year: 2005..It is a very widespread pathogen of wheat, barley and oats. Plant viruses, whose genomes are usually smaller than animal viruses, are easier to culture and use in a variety of in vitro ..
- Suppression of RNA Interference by Herpes Simplex VirusDEBORAH PARRIS; Fiscal Year: 2006..In plants, RNAi is an important adaptive defense which is induced by and targets viruses. Plant viruses counter this attack by producing proteins that suppress components of the pathway, and these silencing ..
- EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONPrem S Paul; Fiscal Year: 2010..NCV scientists conduct basic research on human, animal, and plant viruses, including HIV, herpesvirus, human papillomavirus, PRRSV, and zoonotic viral diseases, with the ultimate goal ..
- SYNTHESIS OF INFECTIOUS BACTERIOPHAGE PARTICLESMasaki Hayashi; Fiscal Year: 1992..an excellent model system for the assembly process of the other spherical viruses, including animal and plant viruses. The linkage of DNA replication and packaging in phi X174 Stage III provides a unique opportunity to ..
- Display of HIV-1 Epitopes on Plant Virus ParticlesKenneth Palmer; Fiscal Year: 2004..Large Scale Biology Corporation has developed a virus-like particle antigen display system based on rod-shaped plant viruses. Linear epitopes that represent the binding site of HIV-1 neutralizing antibodies, and HIV-1 surface ..
- ELECTRON MICROSCOPE AND MICRODENSITOMETERPAULA FLICKER; Fiscal Year: 1991..Dr. Stubbs is determining molecular structure of helical plant viruses, Dr. LeStourgeon is concerned with the structure of nuclear ribonucleoprotein particles, and Dr...
- FASEB CONFERENCE: VIRUS ASSEMBLYJohn Johnson; Fiscal Year: 2002..We also seek to encourage unconventional aspects of virology as represented at our last meeting by presentations describing plant viruses as bio materials and nano reaction vessels.
- FASEB Conference on Virus AssemblyPeter Tattersall; Fiscal Year: 2004..relatively unorthodox applications of virology, as represented at our last meeting by presentations describing plant viruses as scaffolds for nanoelectronics, and animal viruses as platforms for vaccines against infectious diseases and ..
- Roles of host RNA binding proteins in virus replicationPeter Nagy; Fiscal Year: 2008..The tractable in vitro and in vivo TBSV system developed by the investigator could prove beneficial to studies of other, less amenable RNA viruses. [unreadable] [unreadable] [unreadable]..
- Dissecting the mechanism of viral RNA recombinationPeter Nagy; Fiscal Year: 2004..Knowledge of recombination promises untold health benefits by providing means to limit virus infections and safer vaccines. ..
- Regulation of West Nile virus gene expressionTheo Dreher; Fiscal Year: 2004..Though well studied with plant viruses, the involvement of RNAi in the virus/host interplay is in its infancy with animal viruses...
- Upstream ORFs: A general strategy for virus attenuationTheo Dreher; Fiscal Year: 2006..abstract_text> ..
- Role of an essential RNA chaperone in virus replicationPeter Nagy; Fiscal Year: 2006..animal viruses (hepatitis C virus, flavivirus, including West Nile virus and dengue virus, pestiviruses) and plant viruses (luteo- and carmoviruses), understanding the mechanism of RNA replication in tombusviruses is expected to help ..
- Host factors involved in viral RNA recombinationPeter Nagy; Fiscal Year: 2006..Accordingly, RNA recombination has been demonstrated to occur for a large number of human, animal and plant viruses, including poliovirus, dengue virus, infectious bronchitis virus, influenza A virus, hantavirus, hepatitis D ..
- DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSESJames Van Etten; Fiscal Year: 2009..Thus, chlorella viruses are an important model for studying large nucleocytoplasmic dsDNA viruses because they have evolutionary ties to important mammalian viruses, such as the pox viruses and the quarantined African swine fever virus. ..
- Rhabdovirus phosphoproteins: RNA silencing and complex formationMichael Goodin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Role of RNA Structural Switches in the Replication of a (+)-Strand RNA VirusANNE ELIZABETH SIMON; Fiscal Year: 2010....
- Gene Duplication and Genome EvolutionAustin Hughes; Fiscal Year: 2004..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
- Perception of Mechanical Stimuli by Arabidopsis RootsROBYN PERRIN; Fiscal Year: 2004..abstract_text> ..
- Structure and Folding of Frameshifting mRNA PseudoknotsDAVID GIEDROC; Fiscal Year: 2006..These experiments will significantly enhance our understanding of how mRNA structure, stability and folding influence ribosomal recoding required for replication and propagation of infectious plant and human RNA viruses. ..
- REGULATION OF POST-TRANSCRIPTIONAL GENE SILENCINGVicki Vance; Fiscal Year: 2004..Given the antiviral nature of gene silencing in plants, understanding PTGS in plants could well lead to the development of antiviral strategies in humans. ..
- VIRUS BASED BIO-IMAGING & THERAPEUTIC DELIVERY SYSTEMSMark Young; Fiscal Year: 2002..We propose to use site-directed mutagenesis to engineer disulfide linkages and altered pH gating switches at these pores and test for their ability to entrap and release therapeutic materials. ..
- Synaptotagmin function in virus movement and plant developmentSondra G Lazarowitz; Fiscal Year: 2010..As such, it can impact public health by improving nutrition, providing knowledge about growth defects, and identifying novel ways to limit the spread of HIV and other retroviruses. ..
- REOVIRUS OUTER-CAPSID ASSEMBLY & FUNCTIONS IN CELL ENTRYMAX NIBERT; Fiscal Year: 2005..These in vitro recoating methods have been adapted into a new style of molecular genetic analysis of reovirus outer-capsid structure and function by using mutant forms of recombinant proteins for recoating. ..
- Molecular Mechanisms in Reovirus mRNA SynthesisMAX NIBERT; Fiscal Year: 2006..The results of these studies will enhance our understanding of the reovirus core as an elegantly designed molecular machine for mRNA synthesis. ..
- Receptor utilization for influenza virus entry in vivoGARY WHITTAKER; Fiscal Year: 2006..abstract_text> ..
- Multifunctional Nanoparticles for Intracellular DeliveryStefan Franzen; Fiscal Year: 2006..5. Develop strategies for covalent attachment of proteins and oligonucleotides to nanoparticles. 6. Determine of the efficiency of regulated in vitro protein expression using a well-characterized model system. ..
- Entry of Coronaviruses into Host CellsGARY WHITTAKER; Fiscal Year: 2005..IBV would serve as an excellent model system to understand coronavirus entry and fusion, and facilitate the development of future anti-viral drugs. ..
- Reverse genetic analysis of a NecleorhabdovirusAndrew Jackson; Fiscal Year: 2005....
- Characterization of a virus-activated RNA-induced silencing complex(RISC)HERMAN SCHOLTHOF; Fiscal Year: 2007..adapted for this purpose in the laboratory, and to compare the properties with RISC induced by other plant viruses. The underlying hypothesis of the application is that antiviral RISCs not only share many properties but also ..
- Biacore T100Charles Arntzen; Fiscal Year: 2007..unreadable] [unreadable]..
- Trafficking, persistence and evolution of HIV in the CNSPeter Simmonds; Fiscal Year: 2005....
- Control of cap-independent translation by a viral 3' UTRWYATT MILLER; Fiscal Year: 2007..g. dengue, West Nile) that regulate gene expression and replication by long-distance RNA base pairing. Finally, the research will provide fundamental insight on eukaryotic translation initiation mechanisms. ..
- "Analyses of two genes that affect plasmodesmata structure and function"Patricia Zambryski; Fiscal Year: 2007..As PD are essential gatekeepers for cell-to-cell transport during development and for the spread of plant viruses and gene silencing signals, our studies will impact how PD control complex developmental programs and plant ..
- Intracellular mechanisms of reovirus genome replication and particle assemblyMAX NIBERT; Fiscal Year: 2007..abstract_text> ..
- Plant-Made Microbicides and Mucosal Vaccines for STIsCharles Arntzen; Fiscal Year: 2008..The outcomes of this study will define the safety and surrogate effectiveness of a layered system of plant-derived public health products for STIs. ..
- Development of a vaccine for Ebola virus in plant systemCharles Arntzen; Fiscal Year: 2008..An existing murine model will be utilized for immunogenicity and challenge trials, which will be followed by non-human primate vaccine evaluation of the lead vaccine candidates. [unreadable] [unreadable]..
- Understanding the Mechanism of RNA Interference (RNAi)Phillip Zamore; Fiscal Year: 2009....
- EVOLUTION OF IMMUNE RECOGNITION AND EVASIONAustin L Hughes; Fiscal Year: 2010..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..