The present research is aimed to formulate and evaluating herbal mouthwash and evaluating its efficacy against microbial oral cavity load. Due to its physicochemical properties and antimicrobial activity, prepared mouthwash was further evaluated. Malvastrum coromandelianum and Neem extracts and the polyherbal mouth rinse demonstrated good sensitivity to micro-organisms such as E. coli and S. aureus. Natural herbs such as malvastrum coromandelianum, Neem and fennel and many others are used as single or in combination have been scientifically proven to be safe and effective medicine against oral health problems such as bleeding gums, halitosis, mouth ulcers, and preventing tooth decay. Clove is most commonly applied directly to the gums for toothache, pain control during work, and other dental-related issues. We have developed a mouthwash with some common food materials and herbs and which can replace costly chemicals like alcohol, coloring agents and preservatives making our mouthwash economically more viable than commercial mouthwash. The anti-inflammatory and anti-infectious properties of neem make it a powerful treatment for gum disease. The results of this study indicate that the existence of compounds such as glycosides, terpenoids, flavanoids and saponins that can be responsible for the antibacterial efficacy of extracts and polyherbal mouthwash rinse against these microorganisms that are known to be mostly responsible for oral cavity bacterial infection.
Cite this article:
Akshay R. Yadav, Shrinivas K. Mohite, Chandrakant S. Magdum. Preparation and Evaluation of Antibacterial Herbal Mouthwash against Oral Pathogens. Asian J. Res. Pharm. Sci. 2020; 10(3):149-152. doi: 10.5958/2231-5659.2020.00028.4
Akshay R. Yadav, Shrinivas K. Mohite, Chandrakant S. Magdum. Preparation and Evaluation of Antibacterial Herbal Mouthwash against Oral Pathogens. Asian J. Res. Pharm. Sci. 2020; 10(3):149-152. doi: 10.5958/2231-5659.2020.00028.4 Available on: https://ajpsonline.com/AbstractView.aspx?PID=2020-10-3-5
1. Kabra A, Bairagi G. In vitro antimicrobial activity and phytochemical analysis of thepeels of Citrus medica (L). International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012; 3(1): 34-36.
2. Ghassemi F, Momenzade M, Najaﬁan M, Kargar Jahromy H. The effect of hydroalcoholic extract of Oak fruit husks on liver function in Rat (Wistar) The hydroalcoholic extract of Oak fruit huskson liver in Rat (Wistar). Pars of Jahrom University Medical Science. 2014;12(3):7–1.
3. Ehigbai I and Oikeh E: Phytochemical, antimicrobial, and antioxidant activities of different citrus juice concentrates. Food Sci Nutr. 2016; 4(1): 103-109.
4. Eccles R. Menthol and Related Cooling Compounds. Journal of Pharmacy and Pharmacology. 1994;46(8): 618–630.
5. Sittiwet C, Jesadanont S, Pongpech P, Naenna P, Pongsamart S. Antibacterial activity of Malvastrum coromandelianum Gracke against methicillin‑sensitive and methicillin‑resistant strains of Staphylococcus aureus. Curr Res Bacteriol 2008;1:42‑5.
6. Jain P, Bansal D, Bhasin P, Anjali. Antimicrobial activity and phytochemical screening of five wild plants against Escherichia coli, Bacillus subtilis and Staphylococcus aureus. J Pharm Res 2010;3:1260‑2.
7. Acharya R, Padiya RH, Patel ED, Rudrapa HC, Shukla VJ, Chauhan MG. Pharmacognostical evaluation of leaf of Bada Rasna [Nelsonia canescens (Lam.) Spreng.; Acanthaceae]. Anc Sci Life 2012;31:194‑7.
8. Mukhtar H, Ansari S, Bhat Z. Antidiabetic activity of an ethanol extract obtained from the stem bark of Psidium guajava (Myrtaceae). Pharmazie. 2006; 61(8): 725–727.
9. Hoque M, Bari M, Inatsu Y, Antibacterial activity of guava (Psidium guajava L.) and Neem (Azadirachta indica A. Juss.) extracts against foodborne pathogens and spoilage bacteria. Foodborne Pathogens and Disease. 2007; 4(4): 481–488.
10. Abdelrahim H, Almagboul A. Antimicrobial Activity of Psidiumguava. L. Fitoterapia. 2002; 73:713–715
11. Joanna A. Cetyl pyridinium Chloride Mouth Rinse on Gingivitis And Plaque. Journal of Dental Hygiene 2008; 5: 28-32.
12. Hoque M, Bari M, Inatsu Y. Antibacterial activity of guava (Psidium guajava L.) and Neem (Azadirachta indica A. Juss.) extracts against foodborne pathogens and spoilage bacteria. Foodborne Pathogens and Disease. 2007; 4(4): 481–488.
13. Ojewole J. Anti-inflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice. Methods and Findings in Experimental and Clinical Pharmacology. 2006; 28(7): 441–446.
14. Sharma R, Hebbal M, Ankola A, Muruga boopathy V, Shetty SJ. Eﬀect of two herbal mouthwashes on gingival health of school children. J Tradit Complement Med. 2014; 4(4):272–8.
15. Sadeghi M, Bahramabadi R, Assar S. Antibacterial effects of Persica and Matrica Herbal mouth washes on common oral microorganisms: An in vitro study. J Mash Dent Sch.2011; 35(2): 107–114.
16. Anushri M and Yashoda R: Herbs: A good alternatives to current treatments for oral health problems. International Journal of Advanced Health Sciences. 2015; 1(12): 26-29.