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The term nevus (plural: nevi) [1, 2] refers to any benign, circumscribed, hyperplastic skin lesion composed of melanocytes. Some nevi are probably hamartomas arising from an anomaly in embryogenesis while others are more likely acquired neoplasms that developed from melanocytes in the epidermis. Nevi should be distinguished from circumscribed melanosis, which are hyperpigmentations resulting from melanocyte overactivity and are either congenital (café au lait spots), caused by excessive sun exposure in a melanocytic system that is constitutionally susceptible (freckles in redheads) or overtaken by cumulative exposure (age spots), or of exogenous origin.
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