Quantifying Adaptive Evolution in the Drosophila Immune System
Well-characterised immune-related genes arranged by pathway and cellular location, coloured according to the inferred rate of adaptive substitution (a: adaptive substitutions per non-synonymous site between D. melanogaster and D. simulans). Red indicates high rates of adaptive substitution, blue indicates an excess of weakly-deleterious polymorphism. Asterisks indicate those genes that individually display a significant deviation from neutrality in a classical single-locus MK test using the data presented here. In addition to effect size, single-gene significance also strongly reflects the power of the test and will be affected by (e.g.) gene length. To achieve maximum coverage of the immune system, the analysis presented in this figure uses all the sampled populations of D. melanogaster and D. simulans.