Fenben powder is a medication used to treat parasites in animals, particularly roundworms, hookworms, whipworms and some tapeworms. It is also being used as a cancer treatment for humans, and it has shown cytotoxic activity on seven different types of cancer cells.
The invention relates to a novel soluble powder of fenbendazole, which can be easily mixed into animal feed in order to deworm the animal. This can be especially useful in livestock, such as cattle, sheep, goats, pigs and rabbits. In particular, it can be used to treat gastrointestinal nematodes in these animals, as well as lungworms, such as Haemonchus spp and lungworms, such as Chabertia spp. It can also be used to deworm fur animals (foxes, lions, raccoons) as well as birds.
Fenbendazole belongs to the group of broad-spectrum anthelmintics, called benzimidazole carbamates. This family of drugs has been in veterinary and human use for decades and is effective against many different types of worms. It is generally regarded as safe for long-term use in humans and can be used at high doses without significant adverse side effects.
Two commercial formulations of fenbendazole were analyzed in the present study. The samples were dissolved in dimethyl sulfoxide, and the concentration was determined by measuring the absorbance at 254 nm. The dissolved drug was then added to a culture of intestinal nematodes. The culture was incubated at 37 °C and 5% CO2 for 24 h to form a monolayer. At the indicated time points, the culture was rinsed with DMSO and then incubated again in the presence of various concentrations of fenbendazole. Each sample was collected using a 10 mL syringe and immediately filtered through 0.45 m PTFE filters, after which the reconstituted fenbendazole solution was measured in the same way as in the initial analysis.
The results showed that both fenbendazole products tested in the current study released the drug at an identical rate. Neither of the formulations produced any measurable toxicity to the intestinal nematodes. However, the dissolved fenbendazole from one of the commercial formulations was less potent than that of the other commercial product.
The author of the article suggests that the reason for this may be the formulation of the fenbendazole. The fenbendazole in the formulation was more dissoluble than in the other product, which is why it was less potent. The author also notes that this product is not FDA-approved, and it should only be prescribed by a veterinarian. A compounded medication is typically used when there is a specific issue that cannot be managed with an FDA-approved drug, such as if the pet has difficulty taking pill form or if they are allergic to the ingredient in the FDA-approved version of the drug. The veterinarian will recommend a specific dosage, based on the pet’s unique situation. They will also recommend monitoring the pet for a few days to make sure that all of the internal parasites have been killed by the medication. fenben powder