Today a large population-based observational study from Italy regarding the potential benefits of screening athletes for their risk of cardiovascular death was published in the Journal of the American Medical Association. This study compiled the incidence of cardiovascular death in athletic and non-athletic individuals between 12 and 35 years of age between 1979 and 2004 in the Veneto region of Italy. After 1982 all participants in competitive sports were required by Italian law to undergo screening for cardiovascular diseases at risk of sudden death during sports. Their evaluation included a family and personal history, physical examination and electrocardiogram (ECG). The findings of the large study demonstrated that there were 55 deaths in the screened athletes compared to 265 deaths in unscreened non-athletes, and the incidence of death decreased from 1 in 27,777 athletes to 1 death in 250,000 athletes over the period studied, an 89% reduction. The presence of an ECG in the screening criteria differs from the current recommendations by the American Heart Association, but is in line with the recommendations of the Sports Cardiology Study Group of the European Society of Cardiology.
Now before leaping to conclusions, there were some significant limitations to this study, many of which were nicely outlined by Paul Thompson, MD and Benjamin Levine, MD in their accompanying editorial published in the same issue. They include:
- The study was not a controlled comparison of the screening versus non-screening of athletes, but rather a population-based observational study.
- The study did not evaluate the routine use of ECGs compared with more limited screening based on just history and physical examination.
- There are differences in disease prevalence in Italy versus the US: hypertrophic cardiomyopathy is more common in the US whereas arrhythmogenic right ventricular dysplasia is more common in Italy.
- The annual death rate of 1:27,000 athletes at the initiation of the study is high compared to other studies, an this initial death rate accounts for much of the reduction seen over the course of the study,
- The lowest death rate reported in this study was 0.4 deaths per 100,000 person-years, and is similar to the 0.44 per 100,000 person-years reported for US high school and college students in the US between 1983 and 1993.
- women were underrepresented in this study
But one thing seems clear to me. An ECG is a remarkably simple and non-invasive test to evaluate the heart. Right ventricular abnormalities, chamber enlargement or ventricular hypertrophy, abnormal electrical pathways (Wolff-Parkinson-White syndrome), repolarization abnormalities (congenital Long QT Syndrome) and arrhythmias can be readily detected. Physical examination often cannot detect these subtle killers. And while this study is not conclusive and has significant limitations, it serves as the most potent longitudinal study to date of the value of screening to prevent death in our young athletes.
The addition of the ECG to screening of athletes, given this study’s data, should be seriously considered. For a small cost, It might just save a young athlete’s life and keep me off the front page of the Chicago Tribune.