Associate Professor Ki-Bum Lee has developed patent-pending technology that may overcome one of the critical barriers to harnessing the full therapeutic potential of stem cells.
One of the major challenges facing researchers interested in regenerating cells and growing new tissue to treat debilitating injuries and diseases such as Parkinson’s disease, heart disease, and spinal cord trauma, is creating an easy, effective, and non-toxic methodology to control differentiation into specific cell lineages. Lee and colleagues at Rutgers and Kyoto University in Japan have invented a platform they call NanoScript, an important breakthrough for researchers in the area of gene expression. Gene expression is the way information encoded in a gene is used to direct the assembly of a protein molecule, which is integral to the process of tissue development through stem cell therapeutics.
Stem cells hold great promise for a wide range of medical therapeutics as they have the ability to grow tissue throughout the body. In many tissues, stem cells have an almost limitless ability to divide and replenish other cells, serving as an internal repair system.
Transcription factor (TF) proteins are master regulators of gene expression. TF proteins play a pivotal role in regulating stem cell differentiation. Although some have tried to make synthetic molecules that perform the functions of natural transcription factors, NanoScript is the first nanomaterial TF protein that can interact with endogenous DNA. ACS Nano, a publication of the American Chemical Society (ACS), has published Lee’s research on NanoScript. The research is supported by a grant from the National Institutes of Health (NIH).
“Our motivation was to develop a highly robust, efficient nanoparticle-based platform that can regulate gene expression and eventually stem cell differentiation,” said Lee, who leads a Rutgers research group primarily focused on developing and integrating nanotechnology with chemical biology to modulate signaling pathways in cancer and stem cells. “Because NanoScript is a functional replica of TF proteins and a tunable gene-regulating platform, it has great potential to do exactly that. The field of stem cell biology now has another platform to regulate differentiation while the field of nanotechnology has demonstrated for the first time that we can regulate gene expression at the transcriptional level.”
NanoScript was constructed by tethering functional peptides and small molecules called synthetic transcription factors, which mimic the individual TF domains, onto gold nanoparticles.
“NanoScript localizes within the nucleus and initiates transcription of a reporter plasmid by up to 30-fold,” said Sahishnu Patel, Rutgers Chemistry graduate student and co-author of the ACS Nano publication. “NanoScript can effectively transcribe targeted genes on endogenous DNA in a nonviral manner.”
The Latest on: Stem Cell Therapeutics
[google_news title=”” keyword=”Stem Cell Therapeutics” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Stem Cell Therapeutics
- Tvardi Therapeutics to Present at the 34th Annual Piper Sandler Healthcare Conferenceon November 29, 2022 at 5:59 am
Tvardi Therapeutics, Inc. ("Tvardi"), a privately held, clinical-stage biopharmaceutical company focused on the development of STAT3 inhibitors, announced that the management team will present at the ...
- Mission Bio's single-cell transduction assay adopted for AVROBIO's gene therapy pipelineon November 29, 2022 at 5:53 am
New assay measures lentiviral vector transduction efficiency in days AVROBIO to present data on the transduction assay at 4th Annual Gene Therapy ...
- Israeli scientists derive male and female cells from same person for first timeon November 29, 2022 at 4:33 am
A Hadassah team created male and female stem cells with the same genetic code from the same person that only differs in sex chromosomes.
- Context Therapeutics® Nominates CTIM-76 Bispecific Antibody Candidate to Develop Treatment for Claudin 6-Positive Solid Tumorson November 29, 2022 at 4:30 am
CTIM-76 named as lead candidate to target Claudin 6 positive cancers IND submission expected in Q1 2024 Context to host webinar on Thursday, December 1, 2022, at 11 a.m. ET PHILADELPHIA, Nov. 29, 2022 ...
- Stem Cell Reconstructive Market Size In 2022 : Future Scope, Demands and Projected Technology Type Growths to 2028 | 100 Pages Reporton November 28, 2022 at 7:54 pm
" Stem Cell Reconstructive Market " report presents a comprehensive overview, market shares, and growth opportunities of Stem Cell Reconstructive market by product type, application, key manufacturers ...
- New method for scheduling radiation therapy could be more effective at killing tumorson November 28, 2022 at 2:54 pm
Researchers at the University of Waterloo have identified a new method for scheduling radiation therapy that could be as much as 22 percent more effective at killing cancer cells than current standard ...
- Promising New Cancer Therapy Developed by Albert Einstein College of Medicineon November 28, 2022 at 12:46 pm
Immune checkpoints are a normal part of the immune system. Their function is to prevent an immune response from being so powerful that it destroys healthy cells in the body. Immunotherapy drugs called ...
- Cimeio Therapeutics Announces Issuance of Key Patent Covering Cell Therapy Platformon November 28, 2022 at 12:02 pm
Cimeio Therapeutics, a biotechnology company developing a novel approach to cell therapies, today announced the U.S. Patent Office has issued a key patent covering the company's Shielded-Cell & Immuno ...
- CAR T-Cell Therapy Sends Lupus into Remission for Patients, Using Specially-Armed Immune Cellson November 28, 2022 at 8:30 am
The revolutionary cancer CAR T-cell therapy has proven to work also in five patients with lupus, sending the disorder into remission.
- Stem Cell Therapy Market Size 2023-2027 Key Geographical Regions Analysis by Top Key Players with New Reporton November 26, 2022 at 11:40 pm
Nov 27, 2022 (The Expresswire) -- "Stem Cell Therapy Market" New Research Insights Report 2023 | [ Stem Cell Therapy market size was valued at USD ...
via Bing News