Contains glucosamine (sulfate) and chondroitin Glucosamine sulfate is a normal constituent of glycosaminoglycans . They are located in cartilage matrix and synovial fluid. Glucosamine sulfate is used in the treatment of osteoarthritis, particularly of the knee. Research provides evidence of the benefit of the sulfate in the synovial fluid by strengthening cartilage and aiding glycosaminoglycan synthesis. chondroitin, a glycosaminoglycan derived from articular cartilage.