Sat, Jan-30-21, 04:36
Saturated fats may protect against inflammation of the pancreas
Being fat can PROTECT you from certain diseases: People who eat foods high in saturated fats including bacon and cheese are less likely to develop acute pancreatitis, study reveals
- Scientists say saturated fats may protect against inflammation of the pancreas
- They highlight how obesity sometimes seems to protect during acute illnesses
- Saturated fat is found in dairy and fatty meats and is linked with heart disease
We're regularly told to minimise the amount of saturated fats we consume, but a new study suggests that eating foods rich in these fats could actually offer some protection against certain diseases.
Researchers have revealed that eating foods rich in saturated fats, including cakes, bacon and cheese, may reduce your risk of acute pancreatitis.
The US team analysed data from people in 11 countries on how different fats consumed by different nations – either unsaturated or saturated – are linked with the serious condition, where the pancreas becomes inflamed.
Saturated fat is found in butter, lard, fatty meats and cheese – foods heavily consumed in western societies – while unsaturated fats are mostly found in oils from plants and fish and are prevalent in Asian and some South American diets.
The scientists found that high levels of unsaturated fat stored around the abdominal organs generates more of a certain type of molecule that triggers cell injury, inflammation and even organ failure.
Official advice from the NHS is to swap saturated fats for unsaturated fats in our diet to reduce the risk of heart disease.
While this study does not challenge this advice, it does suggest obesity can sometimes protect patients during certain types of acute illnesses.
This 'obesity paradox' has already been controversially suggested in previous studies, but not without backlash from other experts.
'Here, we find that a higher proportion of dietary unsaturated fat can worsen AP [acute pancreatitis] outcomes at a lower adiposity than seen in individuals with a higher proportion of saturated fats in their diet,' say the researchers in their paper, published today in Science Advances.
The NHS says too much fat in your diet, especially saturated fats, can raise cholesterol, which increases the risk of heart disease.
'If you want to reduce your risk of heart disease, it's best to reduce your overall fat intake and swap saturated fats for unsaturated fats,' the NHS website says.
'There's good evidence that replacing saturated fats with some unsaturated fats can help to lower your cholesterol level.'
Draft guidelines from the World Health Organisation recommend people get fewer than 10 per cent of their daily calories (150kcal-250kcal) from saturated fat and instead try to replace them with unsaturated.
Current UK government guidelines also advise cutting down on all fats and replacing saturated fat with some unsaturated fat, as a way to curb obesity figures in the country.
Previous reports have observed that obesity appears to protect patients with acute medical issues such as burns, trauma and cardiovascular surgery.
'Obesity sometimes seems protective in disease,' say the study authors, who are from the Mayo Clinic in Arizona and the Washington University School of Medicine in Missouri.
'This obesity paradox is predominantly described in reports from the Western Hemisphere during acute illnesses.'
However, the impact of fat composition on disease severity has remained unclear.
To better understand 'the obesity paradox', researchers assessed how the type of fats populations consume influence body fat composition and correlate with acute pancreatitis severity.
The team used 20 clinical reports from 11 countries that associated pancreatitis severity with a cutoff body mass index (BMI) of 30 – the point at which someone is officially classified as obese.
They also used seven clinical reports with a cutoff BMI of 25, and dietary fat data from the Food and Agriculture Organisation.
The researchers found a moderate correlation between the percentage of patients with severe acute pancreatitis and their unsaturated fat intake.
But they also observed that a severe form of this disease occurred in individuals with lower BMIs in countries that consumed food with fewer saturated fatty acids.
According to the team, visceral fat (stored around the abdominal organs) with a high unsaturated fat content leads to the generation of more non-esterified fatty acids (NEFAs).
These NEFAs trigger cell injury, systemic inflammation, and organ failure even in individuals with comparatively low body mass indexes (BMIs).
In contrast, visceral fat with a higher saturated fat content interferes with the production of these fatty acids, resulting in milder pancreatitis.
Researchers then conducted further experiments with mice in the lab.
To test how fat composition affects pancreatitis outcomes, researchers fed mice either a diet enriched with linoleic acid (an unsaturated fatty acid) or palmitic acid (a saturated fatty acid).
When the researchers induced pancreatitis in the mice, only 10 per cent of those on the linoleic acid diet survived after three days.
This compared with 90 per cent of those on the palmitic acid diet.
By comparing the mice’s fat pads and fatty acid serum levels, the researchers found that saturated fats do not interact favourably with the enzyme pancreatic triglyceride lipase.
This leads to lower production of damaging long-chain NEFAs.
'Therefore, visceral triglyceride saturation reduces the ensuing lipotoxicity despite higher adiposity, thus explaining the obesity paradox,' the researchers say.
The authors note that other factors they did not study, such as sex, genetic background, and the presence of other diseases, may also contribute to severe acute pancreatitis rates in humans.
In 2019, a team of scientists challenged the World Health Organisation's recommendation for people to cut down on saturated fats.
In their article published in the British Medical Journal, they argued that avoiding saturated fats entirely instead of considering the more general health impact of foods may mean important nutrients are missed.
Eggs, dark chocolate, meat and cheese, for example, are high in saturated but also contain a lot of vital nutrients and vitamins.
Researchers criticised the World Health Organisation for recommending that people cut down on saturated fats instead of being more specific.
In their report they said: 'Scientific and policy missteps may have led to many unnecessary deaths globally, and lessons should be learned.'
'OBESITY PARADOX' DEBUNKED BY SCIENTISTS IN 2018
In a 2018 study, scientists debunked the 'obesity paradox' - a counterintuitive finding that showed people who have been diagnosed with cardiovascular disease live longer if they are overweight or obese compared with people who are normal weight at the time of diagnosis.
Obese people live shorter lives and have a greater proportion of life with cardiovascular disease, reported researchers from Northwestern Medicine study at the time in JAMA Cardiology.
The study showed similar longevity between normal weight and overweight people, but a higher risk for those who are overweight of developing cardiovascular disease during their lifespan and more years spent with cardiovascular disease.
'The obesity paradox caused a lot of confusion and potential damage because we know there are cardiovascular and non-cardiovascular risks associated with obesity,” said Dr. Sadiya Khan, an assistant professor of medicine at Northwestern University Feinberg School of Medicine and a Northwestern Medicine cardiologist.
'I get a lot of patients who ask, "Why do I need to lose weight, if research says I’m going to live longer?"' Khan said.
'I tell them losing weight doesn’t just reduce the risk of developing heart disease, but other diseases like cancer.
'Our data show you will live longer and healthier at a normal weight.'
However, the paradox may exist for other conditions, other research suggests.
A 2021 study found data to suggest that eating a diet rich in unsaturated fat and low in saturated fat, as FDA guidelines suggest, may actually exacerbate acute pancreatitis.
The 'obesity paradox' also occurs in other acute scenarios such as burns, acute heart failure, after trauma, cardiovascular surgery, and during critical illnesses,' the researchers of this study said.