Nose, Olfactory Epithelium, Glands - Hyperplasia
comment:Hyperplasia and dilation of the Bowman’s glands ( Figure 1 and Figure 2 ) are relatively common lesions and are seen to variable degrees in conjunction with olfactory epithelial changes. The hyperplasia may be accompanied by squamous metaplasia or respiratory metaplasia (see Nose, Olfactory Epithelium, Glands - Metaplasia).
recommendation:Hyperplasia of the Bowman's glands should be diagnosed and graded with grading based on the number of Bowman's glands present. The site should be "olfactory epithelium, glands." It is not necessary to specify "Bowman's glands" in the site because glands associated with the olfactory epithelium will be assumed to be Bowman's glands. When both hyperplasia and dilation of the Bowman's glands are present, only Bowman's gland hyperplasia should be diagnosed and given a severity grade, with the dilation described in the pathology pathology narrative. If only dilation is present, then dilation is diagnosed and given a severity grade. A separate diagnosis of respiratory metaplasia, when present, is generally not needed unless warranted by severity. The presence of metaplasia, however, should be described in the pathology narrative.
related links:Nose, Olfactory Epithelium, Glands - Metaplasia
Bogdanffy MS. 1990. Biotransformation enzymes in the rodent nasal mucosa: The value of a histochemical approach. Environ Health Perspect 85:177-186. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/2200661
Maronpot RR. 1990. Pathology Working Group review of selected upper respiratory tract lesions in rats and mice. Environ Health Perspect 85:331-352. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/2384066
Renne R, Brix A, Harkema J, Kittel B, Lewis D, March T, Nagano K, Pino M, Rittinghausen S, Rosenbruch M, Tellier P, Wohrmann T. 2009. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 37(7 suppl):5S-73S. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/20032296
Web page last updated on: February 24, 2015