The cerebellum does not reach its normal developmental potential. Global cerebellar hypoplasia may result from a variety of exogenous or endogenous factors. It is found as a result of intrauterine exposure to drugs (eg. Phenytoin) or irradiation, and as an autosomal recessive trait in a variety of chromosomal disorders, such as trisomies 13, 18 and 21. Primary degeneration of the granular layer of the cerebellum occurs as an autosomal regressive disorder. The MATH1 gene may be a candidate for this disorder.
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