New Mechanism for Chronic Kidney Disease Treatment
A New Mechanism May Lead to New Treatment Options for Chronic Kidney Diseases
Chronic kidney disease (CKD) affects millions of people worldwide and is a major cause of morbidity and mortality. Currently, there are limited treatment options available for CKD, and many patients progress to end-stage renal disease, requiring dialysis or kidney transplantation.
However, recent research has identified a new mechanism that may lead to new treatment options for CKD. The mechanism involves the activation of a protein called hypoxia-inducible factor (HIF) in the kidneys.
HIF is a transcription factor that regulates the expression of genes involved in oxygen homeostasis. In the kidneys, HIF plays a critical role in maintaining the balance between oxygen supply and demand. When the kidneys are exposed to low oxygen levels, HIF is activated, leading to the production of erythropoietin (EPO), a hormone that stimulates the production of red blood cells.
Recent studies have shown that HIF activation in the kidneys can also protect against CKD. In animal models of CKD, HIF activation has been shown to reduce inflammation, fibrosis, and oxidative stress, all of which contribute to the progression of CKD.
Furthermore, HIF activation has been shown to promote the regeneration of damaged kidney cells, which could potentially reverse the damage caused by CKD.
These findings suggest that HIF activation could be a promising target for the development of new treatments for CKD. Several drugs that activate HIF are currently in development, and clinical trials are underway to test their efficacy in treating CKD.
In conclusion, the discovery of a new mechanism involving HIF activation in the kidneys may lead to new treatment options for CKD. By targeting HIF, it may be possible to slow or even reverse the progression of CKD, improving the quality of life for millions of people worldwide.
© Article Copyright 1999-2023
If you would like to republish the content of this or any other article from Life Technology™ for non commercial
Copyright And Royalty Free RSS Feeds For Commercial And Non Commercial Use
. If you would like to republish the content of this or any other article from Life Technology™ for commercial
Life Technology™ News Content Syndication Licence
If you would like to advertise here and on all 100,000+ pages of www.lifetechnology.com visit
Advertise At Life Technology™
. If you would like to publish an article at Life Technology™ visit
Publish An Article At Life Technology™
. If you would like to publish an article at Life Technology™ and Google News visit
Publish An Article At Life Technology™ And Google News
. To sponsor an article at Life Technology™ visit
Sponsor An Article At Life Technology™
. For corporate sponsorship visit
Since 1999 Life Technology™ has published medical science and technology news content totally free of charge.
Because we do not charge a subscription fee we would kindly request that you
Make A Donation To Life Technology™
and please, do share this
article with your coworkers, friends, family and favorite social media platform.
Many would-be kidney donors are ineligible because of their weight or smoking habits: A project helps them qualify
Mechanical thrombectomy safe, effective for high-risk pulmonary embolism
Wasabi shows memory-boosting powers in study
The health benefits of volunteering
It's taking longer to schedule abortions in the US. Doctors fear riskier, more complex procedures
Study reveals Zika's shape-shifting machinery—and a possible vulnerability
Doctors discover many inflammatory bowel disease patients screen positive for malnutrition
New cancer study provides insight into underlying gene mutations in myelodysplastic syndromes
Researchers are upbeat about cardiac regeneration
New drug may be effective for contact lens infection
Metabolic biomarkers may aid mood disorder diagnosis
Getting through the holidays with celiac disease
There's no norovirus outbreak in the UK—so why is a sharp rise in patients being reported?
How unhealthy are ultra-processed foods?
New research paints a dynamic picture of how we respond to high or low oxygen levels
Rare pre- and post-operative recordings show what happens after the brain loses a hub
US approves sickle cell breakthrough with gene editing therapy
A shape-shifting robotic catheter could make heart surgery safer
Mexico City Policy on global aid curtailed family planning services in Africa, study finds
High pressure competitive environment impacts performance of top esports players, new study shows
CDC: Chronic fatigue syndrome prevalence 1.3 percent in 2021 to 2022
Updated systemic lupus erythematosus management recommendations
Battle of the AIs in medical research: ChatGPT vs Elicit
Young people find cocaine use increasingly common in party settings, finds report
Recommendations for fatigue management in inflammatory rheumatic and musculoskeletal diseases
Q&A: How serious is FDA warning about revolutionary blood-cancer treatment?
Evolving insights in blood-based liquid biopsies for prostate cancer interrogation
Looking at first results in using new tools to tackle respiratory syncytial virus in Europe
Scientists develop potential new drug treatment for multiple sclerosis
Multinational study finds biologic therapies can control severe asthma
Spanish-speaking children with type 1 diabetes face barriers to using medical technology
Withholding intubation helpful for comatose patients with acute poisoning
Improving dietary habits of gastrointestinal cancer patients and their caregivers
Australian study finds risky increase in antipsychotic drugs for children
Stem cell study reveals how infantile cystinosis causes kidney failure, and how to cure it
Silica is not the only hazard in engineered stone
The quest to bring osteoarthritis to its knees
Some breast cancer survivors may safely de-escalate mammography three years after surgery
New insight into the impact of arsenic exposure on vaccine efficacy in children
Potentially targetable fusion RNAs may be more common in metastatic breast cancer than previously realized
Skipping adjuvant radiotherapy may not impact risk of recurrence or progression in patients with low-risk DCIS
Shaping tobacco control messages for the Chinese lunar new year through effective short videos
Virtual avatars want you to tell them about your pain. Is that the future of health care?
Study finds social factors drive use of scented menstrual products tied to health risks
Even small amounts of physical activity could be valuable in late-stage lung cancer
No spike in overdoses seen with COVID-era expansion of methadone access
How health system hesitancies contributed to COVID risks
Suicide rates among Black women and girls are on the rise for two decades
Video: Sickle cell disease explained
Researchers discover potential source of stem cells in injury-affected brains of patients
Life Technology™ Medical News
Life Technology™ Science News
Life Technology™ Technology News