Canine leucocyte adhesion deficiency (CLAD)
Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease leading to... more
Canine leukocyte adhesion deficiency (CLAD) is a fatal immunodeficiency disease found in Irish Setters. The condition is caused by mutation in a gene encoding a leucocyte surface molecule, leading to a dysfunction of the granulocytes. Therefore, the cell-cell adhesion events are disturbed. Because their healing capacities are impaired, the affected dogs show severe infections of omphalophlebitis, skin infections, osteomyelitis and gingivitis. They die early in life from multiple severe infections, even if treated with massive doses of antibiotics. At the age of 8 -12 weeks, a swelling of the jawbones and joint inflammations could be observed leading to the CLAD typical unsteady gait.
Irish Red and White Setter, Irish Red Setter
3-5 days after arrival of the sample in the lab