The largest solar telescope, the 1.6-m New Solar Telescope (NST) has been installed and is being commissioned at Big Bear Solar Observatory (BBSO). It has an off-axis Gregorian configuration with a focal ratio of F/52. Early in 2009, first light scientific observations were successfully made at the Nasmyth focus, which is located on the east side of the telescope structure. As the first available scientific instruments for routine observation, Nasmyth focus instrumentation (NFI) consists of several filtergraphs offering high spatial resolution photometry in G-band 430 nm, Ha 656 nm, TiO 706 nm, and covering the near infrared 1083 nm, 1.6 μm, and 2.2 μm. With the assistance of a local correlation tracker system, diffraction limited images were obtained frequently over a field-of-view of 70 by 70 after processed using a post-facto speckle reconstruction algorithm. These data sets not only serve for scientific analysis with an unprecedented spatial resolution, but also provide engineering feedback to the NST operation, maintenance and optimization. This paper reports on the design and the implementation of NFI in detail. First light scientific observations are presented and discussed.