Normally, angiogenesis (the growth of new blood vessels) occurs only in the human uterus and ovaries. Angiogenesis in the eyes can cause blocking of the vision in diabetic retinopathy, age-related macular degeneration, and some glaucoma. The goal of this study was to evaluate the ability of bilberry herb to reduce angiogenesis in event of these eye problems.
There is evidence that bilberry (Vaccinium myrtillus) can block angiogenesis. Bilberry is found in the mountains of Europe and North America. It contains 15 chemicals (anthocyanins) which are strong antioxidants. When given to people with visual disorders, bilberry improves night vision, adaptation to darkness, diabetic eye disease and hypertensive vision problems.
The study results show that bilberry extract does inhibit the formation of tiny tubes (the first stage of artery formation) in cell cultures and live animals. It inhibits the division and migration of cells stimulated by a chemical, VEGF (vascular endothelial growth factor), which causes angiogenesis. VEGF is produced in increased amounts in inflammatory processes.
There is good evidence that bilberry extract acts as an antioxidant also.
CONCLUSION: Bilberry extract inhibits angiogenesis in cell cultures and live animals. It may also reduce the production of VEGF, thereby reducing angiogenesis.
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