This ichthy-triptych displays a designer gene zebra fish line (dubbed “The Fishinator” by Mayo researchers). The slow twitch muscle is tagged with a new protein, derived from coral reefs, called red fluorescent protein. In normal light this genetic change is not seen (middle). However, under green light the muscle is readily apparent (top and overlaid, bottom). The laboratory of Stephen Ekker, Ph.D., is using this line to follow the development of muscle in response to genetic and epigenetic changes, environmental stress, and physical activity. Zebra fish are also used in nicotine research and polycystic kidney disease.