New-formation of Tissue by Karyomitosis. Genesis of new-formations, from indifferent cells; Metaplasia. I. Hypertrophy, compared with normal growth; Hypertrophy (1) from congenital proclivity; (2) compensatory; (3) from increased blood-supply; (4) from direct stimulation; (5) from friction. II. Regeneration of Tissue; limited powers of restoration in man. III. Repair of Injuries; healing of wounds, chiefly blood, epithelium, and connective tissues, also nerve and muscle. IV. Transplantation, effected by experiment in animals, spontaneously and by operation in man.