Yes, Virginia, There Is a Pheromone
WebMD News Archive
April 7, 2000 (Atlanta) -- Women who are nervous, tense, or suffering from
PMS might want to try snuggling up to a man -- preferably one who is hairy and
hasn't showered recently. A new study indicates that women who sniff a chemical
found in male skin and body hair can reduce nervousness, tension, and other
The study, published in a recent issue of Pschoneuroendocrinology,
appears to confirm the existence of a chemical found on human skin that can
change the mood and behavior of other people. And the chemical gains access to
the brain through an organ previously believed to serve no function, according
to the study's authors.
This type of chemical, known as a pheromone, is known to be important in the
animal kingdom and is responsible for many aspects of animal sexual behavior.
The finding that these chemicals also work in humans may lead to new drugs and
a new type of drug-delivery system. In the meantime, it has led to a new drug
Human pheromones have been a subject of debate and research for decades. In
order for a chemical to meet the definition of a pheromone, it not only has to
have an effect on a person's nervous system, it must also alter their behavior.
Pheromones are undetected by the people whom they affect.
"We definitely found that human beings communicate with each other with
pheromones, just like any terrestrial animal, and they do it through the same
organ that all these terrestrial animals have, which is a vomeronasal organ
[VNO], which all human beings have," David L. Berliner, MD, an author of
the study, tells WebMD.
Berliner, who is now president and CEO of Pherin Pharmaceuticals, says that
when he was a professor of anatomy at the University of Utah, he took it for
granted that the human VNO didn't perform any function. In humans, VNOs exist
in small pits inside the nose, but they are very different from the parts of
the nose that detect smells.
Berliner and colleagues at Pherin and the University of Utah School of
Medicine in Salt Lake City set out to see whether a substance called
androstadienone would act as a pheromone on 40 women ages 20 to 45.
The pheromone they studied is a steroid, derived from the male sex hormone
testosterone. It exists most prominently on the male skin surface and body
hair. Before and after they were given the chemical, the women were asked a
battery of questions about their feelings, moods, and personality. Their breath
and heart rates, temperature, heartbeat, and other bodily signs were also
The chemical was applied directly to the VNOs of the research subjects
through a small tube. One second of exposure was enough to produce a response.
Researchers found that the women became less nervous and tense, and had fewer
negative feelings, when the pheromone was applied. They concluded that the
substance had the ability to change human behavior and was therefore a