It's difficult to imagine that America wouldn't have a significant role to play during the prophesied "end times", which the world now seems to be entering into, or that biblical prophecy would ignore it.
The key is to identify the names by which today's nations were referred to in the Bible.
Many people believe that the "Ten Lost Tribes of Israel", those taken into captivity by the Assyrians, eventually migrated to north-western Europe, by which time their original identity had been lost.
One obvious case is Denmark:
A 15th-century Latin chronicle, "Chronicon Holsatiae vetus", found in Gottfried Leibniz's Accessiones historicae (1698), states the Danes were of the Tribe of Dan.
The antiquarian Henry Spelman in 1620 had made a similar claim that the Danes were the Israelite Tribe of Dan, based on the apparent similarity in name.
Additionally, proponents of Nordic and British Israelism have made similar claims about descent from the tribe of Dan.
British Israelite authors such as John Cox Gawler and J. H. Allen identified the Tribe of Dan with Denmark.
While another prominent British Israelite author, Edward Hine, took the view that the tribe of Dan had colonized Denmark and Ulster in Ireland.
— Tribe of Dan - Wikipedia
One might also note the Scottish pork taboo, where Scots don't eat pork or eels, perhaps a tradition that has survived two and a half millennia.
Looking to the Bible itself, God promised to Abraham: "a nation and a company of nations shall be of thee" (Genesis 31:11)
Before his death, Abraham passed on this birthright promise, effectively adopting Joseph's two sons as his own:
And it came to pass after these things, that one told Joseph, Behold, thy father is sick: and he took with him his two sons, Manasseh and Ephraim.
And now thy two sons, Ephraim and Manasseh, which were born unto thee in the land of Egypt before I came unto thee into Egypt, are mine; as Reuben and Simeon, they shall be mine.
And Joseph took them both, Ephraim in his right hand toward Israel's left hand, and Manasseh in his left hand toward Israel's right hand, and brought them near unto him.
And Israel stretched out his right hand, and laid it upon Ephraim's head, who was the younger, and his left hand upon Manasseh's head, guiding his hands wittingly; for Manasseh was the firstborn.
And Joseph said unto his father, Not so, my father: for this is the firstborn; put thy right hand upon his head.
And his father refused, and said, I know it, my son, I know it: he also shall become a people, and he also shall be great: but truly his younger brother shall be greater than he, and his seed shall become a multitude of nations.
And he blessed them that day, saying, In thee shall Israel bless, saying, God make thee as Ephraim and as Manasseh: and he set Ephraim before Manasseh.
Manasseh was prophesied to become a great nation, and Ephraim to become a multitude of nations.
This is part of the same prophecy where Judah was given an even greater blessing, to be the ancestor of the Messiah: "The sceptre shall not depart from Judah, nor a lawgiver from between his feet, until Shiloh come; and unto him shall the gathering of the people be.".
The royal line of Israel started with David and continued to be held within Judah.
British author and journalist Melanie Phillips commented on the recent ascension of Charles III:
… the British monarchy is patterned on ancient Israel.
It’s why the monarch is anointed; it’s why words uttered by “Zadok the Priest,” taken from the first Book of Kings, have been sung at every English coronation since 973 CE.
Some British monarchs in the past have even purportedly traced their line back to King David.
True, ancient Israel was a theocracy and was also eventually destroyed by internal divisions.
Nevertheless, it developed a concept of governance that was to serve as a template for both Britain and America.
— The momentous task for King Charles III
In particular, that "Some British monarchs" applies to Queen Victoria.
Since then (and perhaps before), all male heirs to the throne were circumcised by London's chief mohel.
Charles III was crowned while sitting above the Coronation Stone (Lia Fail, Stone of Destiny, Stone of Scone) as were all his ancestors for thousands of years dating back through Scottish monarchs, and Irish before that.
Legend says that this Stone is "Jacob's Pillow" (Genesis 28:11).
Whether it is that actual stone is irrelevant; what's important is that the story is connected with it.
Some Scottish legends surrounding the Stone of Scone, traditionally used for coronations of Scottish kings in the High Middle Ages, have identified this stone with the Stone of Jacob.
Supposedly the Stone of Jacob was brought to Ireland by the prophet Jeremiah and thence to Scotland.
The 17th-century writer John Speed, describing the coronation of James I, calls the stone at Westminster Abbey by the Latin name, saxum Jacobi.
— Stone of Jacob - Wikipedia
Jeremiah not only brought the Stone, he brought the royal line of David and the Ark of the Covenant with him to Ireland.
Looking at today's world, what would be the obvious choice for two brother nations, one by itself "great", and one "a multitude of nations"?
The United States and the British Commonwealth fit these role perfectly.
Each openly acknowledges (at least until very recently) that they have been richly blessed by the God of Abraham, and that their nations are founded upon the morality and principles presented by the Bible.
Not to be confused with the racist "British Israelism" movement, there are many that believe that Britain and its empire and commonwealth were settled by Ephraim, and that Manasseh's descendants left Britain and founded America.
All biblical end-time references to these two tribes are thus prophecies about America and Britain.
Here is a sample of full-length booklets on the subject: