Every day billions of our cells undergo a "programmed cell death" called apoptosis. This natural and essential process plays an important role in the deconstruction and permanent reconstruction of our body. Under normal conditions, apoptosis ensures the organization of our physical appearance, the architecture of our organs but also the elimination of supernumerary cells, damaged or dysfunctional. The secret of the development of living organisms and their homeostasis lies in the balance between proliferation (growth) and cell loss, where any imbalance or disruption of apoptosis is the key to understanding many pathologies.
During aging, this equilibrium is modified because of slower cell growth and degradation of cell functions. This degradation is accompanied by a reduction in protein synthesis and a slowing down of cell division. This apoptotic imbalance is the main cause of several neurodegenerative pathologies (Alzheimer, Parkinson ...) where excessive apoptosis causes damage to vital cells such as nerve cells by the aggregation of a peptide: β-amyloid.
Humanine is a cytoprotective and anti-inflammatory protein. It decreases the deposits of senile plaques by stimulating the expression of neprilysine: enzyme responsible for the degradation of β-amyloid. Humanine activates the PI3K / Akt anti-apoptotic pathway, then as a competitor complex of the β-amyloid protein (abnormal protein that accumulates in the brain), it binds to the FPRL-1 receptors and thus avoids the spread of the apoptotic wave.
Portulaca oleracea and Umbilicus rupestris play an essential role in cell viability by inhibiting apoptosis under adverse environmental conditions. During environmental changes, they offer protection of the cell balance by acting on the mechanism of programmed cell death.
In cell culture, the extract of the plants Portulaca oleracea and Umbilicus rupestris, PNV™ thus protects the nerve cells and this even in the presence of a substance harmful to the central nervous system, the β-amyloid. The BIOMIMETIC REGULATOR® PNV™ in MILACTIF® 200 thus maintains cell integrity.