It is neurodegenerative disease. The dopamine levels within the brain reduces which leads to the impairment of motor function. The reason behind the cause of Parkinson’s disease is unknow, though genetic and environmental factors are expected to be the reason behind Parkinson’s disease.
· Involuntary movements
· Slow movement
· Stiff and inflexible muscles
· Loss of memory
· By using medicines
· Brain surgery
Medications used in PD
Carbidopa-Levodopa therapy: Tremor, bradykinesia, rigidity is caused because of the less dopamine levels in the body. This can be treated by administrating the carbidopa and levodopa into the body.
Dopamine agonists: These are not as effective as carbidopa and levodopa. However they are lesser side effects
MAO-B inhibitors: MAO-B enzyme is involved in the degradation of dopamine in the brain. The role of the inhibitor is to block the enzyme, so that the dopamine levels in the brain get maintained.
COMT inhibitors: COMT is a inhibitor involved in the degradation of neurotransmitters in the brain. By giving in combination with carbidopa-levodopa, COMT inhibitors will slow down the degradation of dopamine in the brain