Gardening is quite unnatural. It involves unnatural cultivation of mostly unnaturally exotic (nonnative) species of plants. Irrigation delivers more water than seasonal rain provides. Fertilizers contribute more nutrients than endemic soils provide. Pesticides, if necessary, inhibit proliferation of pathogens. Nature simply could not accommodate such demands.
Not only is gardening unnatural, but it also interferes with established ecosystems. Many aggressively invasive plants were formerly desirable exotic plants that naturalized. Many pathogens arrived with exotic plants. Several naturalized plants have potential to distract native pollinators from native plants that rely on their pollination. It is an ecological mess.
Nonetheless, it works. Gardening within the constraints of nature would be unproductive. Most residents of California inhabit chaparral or desert climates that originally sustained limited vegetation. Such limited vegetation sustained a very limited indigenous populace within relatively vast areas. Modern residential parcels would be completely inadequate.
That is the justification for gardening, whether for sustenance, or merely to beautify home environments. Unnatural breeding continues to improve performance of many useful and appealing plants. Unnatural horticultural techniques generate more desirable vegetation within confinement of urban gardens than would naturally inhabit a few acres in the wild.
Nature remains relevant though. All plants originated within nature somewhere. Besides their basic requirements, exotic plants prefer environmental conditions that are similar to those of their natural origin. Some tropical plants crave more warmth and humidity. Some plants prefer more winter chill. Most popular exotic plants rely on supplemental irrigation.
Physical characteristics of many plants necessitate special accommodations also. Roots of plants that naturally compete in dense jungles are likely to damage pavement. Without adequate pruning, native plants that naturally exploit burn cycles can become perilously combustible. Many vines naturally try to overwhelm nearby vegetation and infrastructure.