WEEK - 1
History of Genetics, Scope and significance of genetics
Mendels’ Experiments, Symbols and terminology, Principle of dominance and segregation,
Principle of independent assortment, Mendelian inheritance and probability
WEEK - 2
Allelic variation and gene function- Incomplete dominance, co-dominance, multiple alleles
Gene action-from genotype to phenotype.
Gene interaction, penetrance, expressivity
Epistasis, pleiotropy, interaction with environment.
WEEK - 3
Continuous variation, Quantitative traits - additive alleles, calculating the number of polygenes, significance of polygenic control.
Heritability in broad sense and narrow sense ; Artificial selection.
WEEK - 4
Chromosomes – chromosome number, sex chromosome
Chromosome theory of inheritance - Experimental evidence, non-disjunction as proof of chromosome theory, chromosomal basis of Mendel’s principles of segregation and independent assortment.
Sex linked genes in humans - Haemophilia, colour blindness, fragile X.
Dosage compensation of X- linked genes.
Hyper activation of X-linked gene in male drosophila, Inactivation of X-linked gene in female.
Sex chromosome and sex determination - Human, Drosophila, other animals.
WEEK - 5
Morphology of chromosomes, Structural and Numerical Variations
Linkage, Recombination, Crossing over (Mitotic crossing over)
Chromosome mapping (two point and three point test cross)
WEEK - 6
Maternal Inheritance, Mitochondrial- Snail, poky and petite
Chloroplast – leaf variegation in Mirabilis jalapa, Lojap.
WEEK - 7
Population and gene pool - Allelic frequency, Hardy – Weinberg law - _ Changes in genetic structure of population
Mutation, genetic drift (causes and effect), migration, natural selection.
Non-random mating (heterosis)
WEEK - 8
Introduction – Nature of Genetic material- Discovery of DNA as genetic material
(Griffith, Avery, Hershey Chase)
Strucutre of nucleic acid (A, B and Z model), Super coiling and Topoisomerase,
Types of RNA- Structural and functional.
WEEK - 9
Salient features of prokaryotic and eukaryotic DNA replication.
Homologous recombination, Site specific recombination.
Models of recombination (Holiday model, Double strand break, etc.)
WEEK - 10
Types of mutation, Causes of mutation - Physical and chemical mutagens
Spontaneous and Induced mutations
Molecular basis of mutations
WEEK - 11
Excision Mechanism – Nucleotide, Base
Post Replication Repair- mismatch repair, recombination repair, SOS repair.
Central Dogma, Transcription in prokaryotes, eg: Lac, Tryp operon.
WEEK - 12
Transcription in eukaryotes, RNA processing – nuclear splicing
rRNA and tRNA processing
WEEK - 13
Salient features of genetic code
Translation in prokaryotes
Translation in eukaryotes, Post-translational modification