The new scope of Technology, Knowledge and Learning emphasizes on the increased interest on adaptive and personalized digital learning environments. Educational researchers are faced with new research challenges in the beginning of the twenty-first century, specifically focusing on digital learning, game-based learning, automated assessment, and learning analytics. Digital learning is defined as any set of technology-based methods that can be applied to support learning and instruction. There are many emerging opportunities for research in digital learning aiming to improve the learner's experience and promoting deeper engagement to achieve higher-order thinking skills and to optimize learning outcomes along with ensuring high-quality learning design and instruction. Digital game-based technologies are entering this field to redefine the meaning of learning and instruction in the twenty-first century.