Saint Macedonia was martyred during the persecution in the reign of Decius (249-251), along with Sts Pionius and Limnus, Sabina, and Asclepiades. They suffered at Smyrna, a mercantile city on the eastern shores of the Aegean Sea.
St Macedonia was from the village of Karine. She and her husband Limnus, a priest of the Church of Smyrna, had been cast into prison for confessing Christ. That is where St Pionius and his companions met them.
The Life of St Pionius does not record the details of the martyrdom of Sts Limnus or Macedonia.