Genomes and Genes
Summary: The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.
Publications288 found, 100 shown here
- From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentationA Dupressoir
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS, UMR 8122, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif, France
Placenta 33:663-71. 2012..out one or both mouse syncytin-A and -B genes provided evidence that they indeed play a critical role in placentation. We discuss the possibility that the immunosuppressive domain embedded within retroviral envelope glycoproteins ..
- Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentationChristian Lavialle
UMR 8122, Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS, Institut Gustave Roussy, 94805 Villejuif, France
Philos Trans R Soc Lond B Biol Sci 368:20120507. 2013....
- Immunology of placentation in eutherian mammalsAshley Moffett
King s College, Cambridge CB2 1ST, UK
Nat Rev Immunol 6:584-94. 2006..At the implantation site, cells from the mother and the fetus intermingle during pregnancy. Unravelling what happens here is crucial to our understanding of why some human pregnancies are successful whereas others are not...
- Ancestral capture of syncytin-Car1, a fusogenic endogenous retroviral envelope gene involved in placentation and conserved in CarnivoraGuillaume Cornelis
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8122, Institut Gustave Roussy, F 94805 Villejuif, France
Proc Natl Acad Sci U S A 109:E432-41. 2012Syncytins are envelope protein genes of retroviral origin that have been captured for a function in placentation. Two such genes have already been identified in simians, two distinct, unrelated genes have been identified in Muridae, and a ..
- The influence of the intrauterine environment on human placental developmentGraham J Burton
Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
Int J Dev Biol 54:303-12. 2010..Protein synthesis inhibition therefore appears to be a common mechanism for regulating placental development under different adverse conditions...
- Placentation and maternal investment in mammalsIsabella Capellini
Evolutionary Anthropology Research Group, Department of Anthropology, Durham University, Dawson Building, South Road, Durham DH1 3LE, United Kingdom
Am Nat 177:86-98. 2011..We suggest that the effects of placental interdigitation on growth rates and the way that these are traded off against gestation length may be promising avenues for understanding the evolutionary dynamics of parent-offspring conflict...
- IFPA Award in Placentology Lecture: Complicated interactions between genes and the environment in placentation, pregnancy outcome and long term healthC T Roberts
Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
Placenta 31:S47-53. 2010..b>Placentation and trophoblast invasion and its inhibitors in other species may provide new ideas for understanding what goes ..
- Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentationG C Gurtner
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
Genes Dev 9:1-14. 1995..A small number of VCAM-1-deficient embryos survived, presumably by circumventing the placentation defects...
- Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentationCécile Esnault
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de la Recherche Scientifique, Institut Gustave Roussy, Villejuif, France
PLoS Genet 9:e1003400. 2013Syncytins are envelope genes of retroviral origin that have been co-opted for a role in placentation. They promote cell-cell fusion and are involved in the formation of a syncytium layer--the syncytiotrophoblast--at the materno-fetal ..
- High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentationJacob Farhi
Infertility and IVF Unit, Department of Obstetrics and Gynecology, Helen Schneider Hospital for Women, Beilinson Campus, Rabin Medical Center, Petach Tikva 49100, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Reprod Biomed Online 21:331-7. 2010..concentration on human chorionic gonadotrophin (HCG) day in IVF cycles on endometrial receptivity and placentation. A retrospective cohort included all women attending the IVF unit in 2006 and 2007, with the best prognosis to ..
- Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interfaceM J Soares
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Placenta 33:233-43. 2012The rat possesses hemochorial placentation with deep intrauterine trophoblast cell invasion and trophoblast-directed uterine spiral artery remodeling; features shared with human placentation...
- Dickkopf-1 secreted by decidual cells promotes trophoblast cell invasion during murine placentationSha Peng
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang District, Beijing 100101, China
Reproduction 135:367-75. 2008..However, the role of Dkk1 in trophoblast cell invasion during placentation remains unclear...
- The mammalian yolk sac placentaClaudia Freyer
Department of Zoology, The University of Melbourne, Melbourne, Victoria, Australia
J Exp Zool B Mol Dev Evol 312:545-54. 2009..Thus, the yolk sac of humans, like that of all viviparous mammals, is a true placenta crucial for early embryonic development and survival...
- Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in miceRoman Szabo
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
Development 136:2653-63. 2009..This study indicates that unregulated matriptase-dependent cell surface proteolysis can cause a diverse array of abnormalities in mammalian development...
- Endogenous retroviruses in trophoblast differentiation and placental developmentSarah G Black
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
Am J Reprod Immunol 64:255-64. 2010....
- Deep placentationR Pijnenborg
Department of Woman and Child, University Hospital Leuven, B 3000 Leuven, Belgium
Best Pract Res Clin Obstet Gynaecol 25:273-85. 2011Deep placentation in human pregnancy is realised by deep invasion of the placental bed by the extravillous trophoblast, involving the decidua and the inner (junctional zone) myometrium...
- Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsiaI Caniggia
Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, Toronto, Ontario, Canada
Placenta 21:S25-30. 2000During early pregnancy, placentation occurs in a relatively hypoxic environment which is essential for appropriate embryonic development...
- Cytokines, chemokines and growth factors in endometrium related to implantationE Dimitriadis
Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
Hum Reprod Update 11:613-30. 2005The complexity of the events of embryo implantation and placentation is exemplified by the number and range of cytokines with demonstrated roles in these processes...
- Abnormal placentation: twenty-year analysisSerena Wu
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Chicago, Ill, USA
Am J Obstet Gynecol 192:1458-61. 2005This study was undertaken to determine whether the rate of abnormal placentation is increasing in conjunction with the cesarean rate and to evaluate incidence, risk factors, and outcomes.
- Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2Susan E Hiby
Department of Pathology, University of Cambridge, Cambridge, UK
J Clin Invest 120:4102-10. 2010..by the fetal trophoblast cells and killer Ig-like receptors (KIRs) on the maternal uNK cells--influence placentation in human pregnancy...
- A guide towards pre-pregnancy management of defective implantation and placentationAdam C Urato
Department of Obstetrics and Gynecology, Tufts Medical Center and Tufts University School of Medicine, 800 Washington Street, Boston, MA 02111, USA
Best Pract Res Clin Obstet Gynaecol 25:367-87. 2011..Currently, the cause of such complications are being increasingly recognised as defective implantation and placentation. The molecular mechanisms responsible for normal and abnormal implantation are an area of active investigation...
- A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentationGui Ying Nie
Prince Henry s Institute of Medical Research, P O Box 5152, 246 Clayton Road, Clayton, Victoria 3168, Australia
Mol Hum Reprod 9:279-90. 2003..Based on PRSP protein domain structure and its unique expression during pregnancy, we propose that PRSP plays an important role in the formation/function of the placenta...
- Placentation in Sigmodontinae: a rodent taxon native to South AmericaPhelipe O Favaron
Department of Surgery, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
Reprod Biol Endocrinol 9:55. 2011..Sigmodontinae, known as "New World rats and mice," is a large subfamily of Cricetidae for which we herein provide the first comprehensive investigation of the placenta...
- Altered plasma concentrations of leptin, transforming growth factor-beta(1) and plasminogen activator inhibitor type 2 at 18 weeks of gestation in women destined to develop pre-eclampsia. Circulating markers of disturbed placentation?T Clausen
Department of Obstetrics and Gynaecology, Aker and Ulleval University Hospitals, Oslo, Norway
Placenta 23:380-5. 2002In many pre-eclamptic women the placentation process seems to be disturbed...
- How Does the maternal immune system contribute to the development of pre-eclampsia?A Moffett
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Placenta 28:S51-6. 2007..When considering the primary defect of placentation that leads to pre-eclampsia the focus should be on the intermingling of the invasive placental trophoblast ..
- Embryo-maternal communication: signalling before and during placentation in cattle and pigEsben Ostrup
Section of Biomaterials, University of Oslo, PO Box 1109, Blindern, 0317 Oslo, Norway
Reprod Fertil Dev 23:964-75. 2011..and transcriptional changes in the endometrium as well as epigenetic regulation mechanisms directing the placentation. An increasing knowledge of the embryo-maternal communication might not only help to improve the fertility of ..
- Review: Immunogenetics of human placentationP Parham
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
Placenta 33:S71-80. 2012..favor reproductive success and other groups of receptors and ligands that have been correlated with disordered placentation. Human populations that have survived successive episodes of epidemic disease and population bottlenecks ..
- Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentationXiaofei Sun
Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 107:16887-92. 2010In most mammals, placentation is critical for fetal development and pregnancy success. Exposure to marijuana during pregnancy has adverse effects, but whether the placenta is a target of cannabinoid/endocannabinoid signaling is not known...
- The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentationS Afonso
Department of Cell, Developmental and Neurobiology, Nelson Labs, Busch Campus, Rutgers University, Piscataway, NJ 08855, USA
Development 124:3415-25. 1997..This work adds to our understanding of implantation and placentation by reporting the expression and function of another class of proteinases/inhibitors closely related to invasive ..
- A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentationMarc P Stemmler
Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
Dev Dyn 239:2330-44. 2010..Placentas without Cdh1 expression are impaired and incapable of establishing a proper connection between the embryonic and the maternal blood vessels for efficient nutrient and oxygen transport...
- An unusual feature of yolk sac placentation in Necromys lasiurus (Rodentia, Cricetidae, Sigmodontinae)P O Favaron
Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo, Brazil
Placenta 33:578-80. 2012We studied the development of the inverted yolk sac in a New World rodent, Necromys lasiurus during early placentation. Ten implantation sites were investigated by means of histology, immunohistochemistry and electron microscopy...
- Dynamic evolution of endogenous retrovirus-derived genes expressed in bovine conceptuses during the period of placentationSo Nakagawa
Center for Information Biology, National Institute of Genetics, Japan
Genome Biol Evol 5:296-306. 2013..These results suggest that placentation depends on various retrovirus-derived genes that could have replaced endogenous predecessors during evolution.
- Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope geneAnne Dupressoir
Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
Proc Natl Acad Sci U S A 106:12127-32. 2009....
- Osteopontin: roles in implantation and placentationGreg A Johnson
Center for Animal Biotechnology and Genomics, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
Biol Reprod 69:1458-71. 2003..OPN has the potential to profoundly impact pregnancy, and investigators are now challenged to focus on the mechanistic nature of the functions of this multifaceted and major component of the uterine-placental microenvironment...
- Role of platelets in placentationYukiyasu Sato
Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
Med Mol Morphol 43:129-33. 2010..Future studies should aim to elucidate other mechanisms that could regulate endovascular trophoblast infiltration...
- A comparison of placental development and endocrine functions between the human and mouse modelA Malassine
INSERM U 427, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Rene Descartes, Paris, France
Hum Reprod Update 9:531-9. 2003..Herein, the similarities and differences between the human and mouse models are reviewed, with a view to encouraging caution in the extrapolation of results from one model to the other...
- The evolutionary significance of placental interdigitation in mammalian reproduction: contributions from comparative studiesI Capellini
Department of Biological Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, UK
Placenta 33:763-8. 2012..Contrary to suggestions that highly invasive hemochorial placentation is beneficial to fetal development, recent comparative studies have revealed that interdigitation - the degree ..
- Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentationValerie Nadeau
Centre de recherche en cancérologie de l Université Laval, Centre Hospitalier Universitaire de Quebec, L Hôtel Dieu de Québec, Quebec, QC, G1R 2J6, Canada
Development 136:1363-74. 2009..Thus, even though Map2k1 plays a predominant role, these results enlighten the function of Map2k2 in placenta development...
- How does variability of immune system genes affect placentation?F Colucci
Department of Obstetrics and Gynaecology, University of Cambridge Clinical School, The Rosie Hospital, Cambridge, UK
Placenta 32:539-45. 2011..for major histocompatibility complex (MHC) molecules and natural killer receptors (NKR) may impact on human placentation. MHC and NKR are the most polymorphic human genes...
- Comparative placentation: some interesting modifications for histotrophic nutrition -- a reviewA C Enders
Department of Cell Biology and Human Anatomy, University of California, One Shields Avenue, Davis, CA 95616, USA
Placenta 27:S11-6. 2006....
- Genomic imprinting in marsupial placentationMarilyn B Renfree
Department of Zoology, ARC Centre of Excellence for Kangaroo Genomics, The University of Melbourne, Melbourne, Victoria 3010, Australia
Reproduction 136:523-31. 2008..there may have been strong selection for the retention of imprinted regions that arose during the evolution of placentation. There is currently no evidence for genomic imprinting in the egg-laying monotreme mammals...
- Cellular signatures in the primary visual cortex of phylogeny and placentationEric Lewitus
Department of Anthropology, University College London, London, WC1H 0BW, UK
Brain Struct Funct 217:531-47. 2012..We further tested cellular densities against mode of placentation to determine whether a relationship may exist...
- Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activationRoman Szabo
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 8:e1002937. 2012..Hypomorphic mutations in Prss8, encoding the GPI-anchored serine protease, prostasin (CAP1, PRSS8), restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation ..
- Costs and benefits of polyandry in a placental poeciliid fish Heterandria formosa are in accordance with the parent-offspring conflict theory of placentationO Ala-Honkola
Department of Biological and Environmental Sciences, PO Box 65, 00014 University of Helsinki, Finland
J Evol Biol 24:2600-10. 2011..Offspring conflict may thus reduce the benefits of polyandry in viviparous species...
- Review: The evolving placenta: different developmental paths to a hemochorial relationshipA C Enders
Department of Cell Biology and Human Anatomy, School of Medicine, University of California Davis, Davis, CA 95616, USA
Placenta 33:S92-8. 2012..Variations from the major patterns of development also occur. The way in which the definitive placental form is achieved developmentally should be considered when using placental structure to extrapolate evolution of placentation.
- Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal developmentLindsey N Kent
Institute for Reproductive Health and Regenerative Medicine, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Int J Dev Biol 56:255-61. 2012Phenotypic characterization of Akt1 and Igf2 null mice has revealed roles for each in the regulation of placentation, and fetal and postnatal growth...
- Natural killer cells and pregnancyAshley Moffett-King
Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, UK
Nat Rev Immunol 2:656-63. 2002....
- Phylogenetic evidence for early hemochorial placentation in eutheriaM G Elliot
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6
Placenta 30:949-67. 2009..All of these approaches are consistent in indicating that highly invasive hemochorial placentation, as found in human beings and numerous other taxa, was an early evolutionary innovation present in the most ..
- Oxygen, the Janus gas; its effects on human placental development and functionGraham J Burton
Centre for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
J Anat 215:27-35. 2009..Establishing an inviolable maternal blood supply for the second and third trimesters is therefore one of the most crucial aspects of human placentation.
- Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the ratDamien P Hewitt
School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
Endocrinology 147:5568-74. 2006..Our data suggest that glucocorticoid-induced restriction of fetal and placental growth is mediated, in part, via inhibition of placental VEGF expression and an associated reduction in placental vascularization...
- Maternal undernutrition influences placental-fetal developmentLouiza Belkacemi
Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, and David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
Biol Reprod 83:325-31. 2010..This review associates fetal growth with maternal nutrition during pregnancy, placental growth and vascular development, and placental nutrient transport...
- Defective implantation and placentation: laying the blueprint for pregnancy complicationsErrol R Norwitz
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale New Haven Hospital, Yale University School of Medicine, 333 Cedar Street, LCI 800, New Haven, CT 06443, USA
Reprod Biomed Online 13:591-9. 2006Normal implantation and placentation is critical for pregnancy success...
- Equine placentationW R Allen
University of Cambridge, Department of Clinical Veterinary Medicine Equine Fertility Unit, Mertoun Paddocks, Newmarket, Suffolk, UK
Reprod Fertil Dev 13:623-34. 2001..Placental production of progesterone and 5alpha-reduced progestagens, on the other hand, depends on both maternal and fetal adrenal sources of pregnenelone...
- Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriageS E Hiby
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
Hum Reprod 23:972-6. 2008The natural killer (NK) cells at the site of placentation express killer-cell immunoglobulin-like receptors (KIR) that can bind to human leukocyte antigen (HLA)-C molecules on trophoblast cells...
- Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouseV Sapin
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, C U de Strasbourg, Illkirch, France
Dev Dyn 208:199-210. 1997..5 to 19.5 days postcoitum (dpc). During early placentation, RBP and RALDH-2 gene expression are restricted to the endoderm of the visceral yolk sac and the outer uterine ..
- Chemokine CXCL16, a scavenger receptor, induces proliferation and invasion of first-trimester human trophoblast cells in an autocrine mannerYu Huang
Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China
Hum Reprod 21:1083-91. 2006....
- Angiogenesis during primate placentation in health and diseaseChristine Wulff
Department of Obstetrics and Gynaecology of the University of Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany
Reproduction 126:569-77. 2003..In primates including humans, this exchange is attained by successful haemochorial placentation which requires the transformation of maternal intramyometrial spiral arterioles by trophoblast invasion to gain ..
- The effect of intrauterine growth retardation on the expression of developmental factors in porcine placenta subsequent to the initiation of placentationL A Blomberg
Animal Biosciences and Biotechnology Laboratory, Animal and Natural Resources Institute, USDA Agricultural Research Service, Beltsville, MD 20705, USA
Placenta 31:549-52. 2010..Since ENOS could modulate vascular tone and angiogenesis via nitric oxide production, data suggest that the increase in IUGR may be an adaptive response to poor perfusion to maintain pregnancy...
- Role of HERV-W syncytin-1 in placentation and maintenance of human pregnancySamina Noorali
South Carolina Center for Biotechnology, Claflin University, Orangeburg, SC 29115, USA
Appl Immunohistochem Mol Morphol 17:319-28. 2009..The products of 2 of 16 identified genes of HERV-W seem to play a pivotal role in the placentation. These 2 genes are HERV-W env glycoprotein (syncytin-1) and HERV-FRD env glycoprotein (syncytin-2)...
- Pathophysiology of placentation abnormalities in pregnancy-induced hypertensionMitsuko Furuya
Department of Pathology, Yokohama City University Graduate School of Medicine, 3 9 Fuku ura, Kanazawa, Yokohama, Japan
Vasc Health Risk Manag 4:1301-13. 2008..Genetic susceptibilities and poor placentation have been investigated intensively to understand the pathophysiology of PIH...
- Human pregnancy: the role of chemokine networks at the fetal-maternal interfaceKristy Red-Horse
Department of Pathology, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0512, USA
Expert Rev Mol Med 6:1-14. 2004..Thus, as in other systems, at the fetal-maternal interface chemokines might regulate multiple functions...
- Effects of bisphenol A (BPA) on placentation and survival of the neonates in miceToru Tachibana
Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Japan
J Reprod Dev 53:509-14. 2007The effects of bisphenol A (BPA) on placentation have not been fully determined. The aim of this study was to clarify the structural changes of the placenta, abortion rate, and survival of neonates after BPA administration in mice...
- Trophoblast stem cells: models for investigating trophectoderm differentiation and placental developmentGordon C Douglas
Wisconsin National Primate Research Center, University of Wisconsin, 1223 Capitol Court, Madison, Wisconsin 53715 1299, USA
Endocr Rev 30:228-40. 2009..In hemochorial placentation, these cells play especially important roles, interfacing with and modifying the cells of the maternal decidua...
- Uterine natural killer cells in species with epitheliochorial placentationH Engelhardt
Department of Animal and Poultry Science, University of Guelph, Ont, Canada
Nat Immun 15:53-69. 1996..The best known examples of this form of placentation are the domestic livestock species...
- Evolution of invasive placentation with special reference to non-human primatesAnthony M Carter
Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsloewsvej 21, DK 5000 Odense, Denmark
Best Pract Res Clin Obstet Gynaecol 25:249-57. 2011It is now possible to view human placentation in an evolutionary context because advances in molecular phylogenetics provide a reliable scenario for the evolution of mammals...
- Prediction of macrosomia at birth in type-1 and 2 diabetic pregnancies with biomarkers of early placentationS Kuc
Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
BJOG 118:748-54. 2011..To evaluate the value of first trimester placental biomarkers (fβ-hCG, PAPP-A, ADAM12, PP13 and PlGF) and fetal nuchal translucency (NT) in the prediction of macrosomia at birth in pregestational type-1 and type-2 diabetes (PGDM)...
- Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolutionEric Jauniaux
Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
Hum Reprod Update 12:747-55. 2006..In contrast, in pre-eclampsia the trophoblastic invasion is sufficient to allow early pregnancy phases of placentation but too shallow for complete transformation of the arterial utero-placental circulation, predisposing to a ..
- Platelet-endothelial cell adhesion molecule-1 is expressed by a subpopulation of human trophoblasts: a possible mechanism for trophoblast-endothelial interaction during haemochorial placentationG Coukos
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
Mol Hum Reprod 4:357-67. 1998..adhesive interaction between trophoblasts and maternal vascular endothelium during the process of haemochorial placentation. Regulation of PECAM-1 expression by human trophoblasts may play a critical role in normal and abnormal ..
- Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsiaMichelle Silasi
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Kirstein 3182, Boston, MA 02215, USA
Obstet Gynecol Clin North Am 37:239-53. 2010..The molecular pathogenesis of preeclampsia is just now being elucidated. It has been proposed that abnormal placentation and an imbalance in angiogenic factors lead to the clinical findings and complications seen in preeclampsia...
- Mid-trimester placentation assessment in high-risk pregnancies using maternal serum screening and uterine artery DopplerReli Hershkovitz
Maternal Medicine Clinic, The Obstetric Hospital, University College London Hospitals NHS Trust, London, UK
Hypertens Pregnancy 24:273-80. 2005..To determine the value of uterine artery velocimetry and mid-trimester maternal serum AFP/hCG measurements in predicting pregnancy complications in a high-risk group of pregnant patients...
- The evolving placenta: convergent evolution of variations in the endotheliochorial relationshipA C Enders
Department of Cell Biology and Human Anatomy, University of California Davis, School of Medicine, Davis CA 95616, USA
Placenta 33:319-26. 2012..It is concluded that the endotheliochorial placenta is more widespread and diversified than originally thought, with the variant with cellular trophoblast in particular appearing in several species studied recently...
- The fetomaternal interface in the placenta of three species of armadillos (Eutheria, Xenarthra, Dasypodidae)Lorenna C Rezende
Department of Surgery, Faculty of Veterinary Medicine, University of Sao Paulo, Av Prof Dr Orlando Marques de Paiva, no 87, Cidade Universitaria, Sao Paulo, SPCEP 05508 000, Brazil
Reprod Biol Endocrinol 10:38. 2012..Placental characters vary among Xenarthra, one of four supraordinal clades of Eutheria. Armadillos are known for villous, haemochorial placentas similar to humans. Only the nine-banded armadillo has been well studied so far...
- Placentation in the African elephant, Loxodonta africana. IV. Growth and function of the fetal gonadsW R Allen
University of Cambridge, Department of Veterinary Medicine Equine Fertility Unit, Mertoun Paddocks, Woodditton Road, Newmarket, Suffolk CB8 9BH, UK
Reproduction 130:713-20. 2005....
- Evolution of the placenta during the early radiation of placental mammalsAndrea Mess
Museum of Natural History, Department of Research, Humboldt University Berlin, Invalidenstr 43, DE 10115 Berlin, Germany
Comp Biochem Physiol A Mol Integr Physiol 148:769-79. 2007..We show that epitheliochorial placentation, the least invasive type, is a derived state and discuss factors that may have determined its evolution with ..
- Imprinted genes, placental development and fetal growthA L Fowden
Department of Physiology, Cambridge, UK
Horm Res 65:50-8. 2006....
- hCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentationLaurence A Cole
USA hCG Reference Service Reference Service, Women s Health Research, Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM 87131, USA
J Reprod Immunol 82:112-8. 2009..of regular chorionic gonadotropin (CG) and hyperglycosylated CG are linked with the evolution of hemochorial placentation in primates...
- Vascular biology in implantation and placentationBerthold Huppertz
Department of Anatomy II, University Hospital RWTH Aachen, Aachen, Germany
Angiogenesis 8:157-67. 2005..This review tries to cover all the above-mentioned topics and will try to depict the consequences of poor placentation on mother and fetus.
- Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in miceManyu Li
Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Clin Invest 116:2653-62. 2006..to implicate both maternal and, to a lesser extent, embryonic levels of AM in the processes of implantation, placentation, and subsequent fetal growth...
- HtrA3, a serine protease possessing an IGF-binding domain, is selectively expressed at the maternal-fetal interface during placentation in the mouseG Nie
Prince Henry s Institute of Medical Research, PO Box 5152, 246 Clayton Road, Clayton, Victoria 3168, Australia
Placenta 27:491-501. 2006Hemochorial placentation involves highly regulated interactions between fetal- and maternal-derived cells...
- Chromosome-substituted rat strains provide insights into the genetics of placentationToshihiro Konno
Institute for Reproductive Health and Regenerative Medicine and Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Physiol Genomics 43:930-41. 2011The rat possesses a hemochorial form of placentation. Pronounced intrauterine trophoblast cell invasion and vascular remodeling characterize this type of placentation. Strain-specific patterns of placentation are evident in the rat...
- Evolution and development of fetal membranes and placentation in amniote vertebratesKirsten Ferner
Department of Research, Museum für Naturkunde Leibniz Institute for Research on Evolution and Biodiversity at the Humboldt University Berlin, Berlin, Germany
Respir Physiol Neurobiol 178:39-50. 2011We review aspects of fetal membrane evolution and patterns of placentation within amniotes, the most successful land vertebrates. Special reference is given to embryonic gas supply...
- Human placentation from nidation to 5 weeks of gestation. Part II: Tools to model the crucial first daysJ L James
Department of Obstetrics and Gynecology, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand
Placenta 33:335-42. 2012..and in vitro cell culture models that have been used to study the earliest stages of human implantation and placentation from nidation to 5 weeks of gestation...
- Maternal diabetes affects specific extracellular matrix components during placentationF R C Giachini
Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
J Anat 212:31-41. 2008..b>Placentation is probably guided by the composition and organization of the endometrial extracellular matrix...
- Expression of human leukocyte antigen-G during normal placentation and in preeclamptic pregnanciesXiaoming Zhu
Department of Obstetrics and Gynecology, Tangdu Hospital, The Fourth Military Medical University, Xi an, PR China
Hypertens Pregnancy 31:252-60. 2012This study was undertaken to investigate the expression pattern of human leukocyte antigen-G (HLA-G) during normal placentation and determine whether altered expression of HLA-G is associated with severe preeclampsia.
- IFPA Meeting 2010 Workshop Report I: Immunology; ion transport; epigenetics; vascular reactivity; epitheliochorial placentation; proteomicsC Abad
Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
Placenta 32:S81-9. 2011..5. The workshop on epitheliochorial placentation covered current advances from in vivo and in vitro studies of different domestic species. 6...
- Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentationR E Leach
Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, USA
J Clin Endocrinol Metab 84:3355-63. 1999..These findings suggest that HB-EGF promotes implantation and trophoblast invasion through paracrine and autocrine signaling as cells penetrate the stroma and displace the arteriole endothelium...
- IGF-I Overexpression causes fetal loss during placentation in miceOrie Nakamura
Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University
J Reprod Dev 50:375-80. 2004..Thus, it is likely that IGF-I plays a role in the decidual formation through regulation of uNK cells. This is the first report to demonstrate that IGF-I overexpression can cause fetal loss during murine placentation.
- Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation modelTakako Tabata
Department of Cell and Tissue Biology, School of Dentistry, University of California, San Francisco, USA
Am J Pathol 181:1540-59. 2012..In this in vivo human placentation model, human cytotrophoblasts invade the renal parenchyma, remodel resident arteries, and induce a robust ..
- Trophoblast invasion and placentation: molecular mechanisms and regulationFrédéric van den Brûle
Laboratory of Tumor Biology and Development, Pathology B23, CHU Liege, Liege, Belgium
Chem Immunol Allergy 88:163-80. 2005Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and ..
- Polymorphism A1/A2 in the cell surface integrin subunit β3 and disturbance of implantation and placentation in women with recurrent pregnancy lossPetar D Ivanov
Department of Chemistry and Biochemistry, University of Medicine, Pleven, Bulgaria
Fertil Steril 94:2843-5. 2010..3% versus 16.4% in controls), but it was much more pronounced in 67 women with RPL between 10 and 20 weeks of gestation (41.8%), illustrating its role in recurrent fetal loss...
- Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disordersAnthony M Carter
Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsloewsvej 21, DK 5000 Odense, Denmark
Reproduction 141:391-6. 2011..The fetal genotype is in part derived from the father providing an explanation for the paternal contribution to reproductive disorders...
- Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restrictionAmy S Erickson Hagen
Department of Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
Pediatr Res 58:1228-32. 2005..b>Placentation requires extensive vasculogenesis and subsequent angiogenesis, in both maternal and fetal tissues...
- Placental development during early pregnancy in sheep: vascular growth and expression of angiogenic factors in maternal placentaAnna T Grazul-Bilska
Department of Animal Science, Center for Nutrition and Pregnancy, Cell Biology Center, North Dakota State University, Fargo, North Dakota 58105, USA
Reproduction 140:165-74. 2010..This more complete description of early placental angiogenesis may provide the foundation for determining whether placental vascular development is altered in compromised pregnancies...
- The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheepRyan L Ashley
Department of Animal and Range Sciences, New Mexico State University, Las Cruces, New Mexico, USA
Reprod Biol Endocrinol 9:148. 2011The progression of implantation and placentation in ruminants is complex and is regulated by interplay between sex steroids and local signaling molecules, many of which have immune function...
- Defective placentation and resultant oxidative stress play a similar role in complete hydatidiform mole to that in preeclampsia and early pregnancy lossMuge Harma
Department of Obstetrics and Gynecology, Medical School, Harran University, Sanliurfa, Turkey
Med Hypotheses 66:100-2. 2006Defective placentation and resultant oxidative stress are believed to be largely responsible for preeclampsia and early pregnancy loss...
- Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethalityHiroko Habuchi
Institute for Molecular Science of Medicine and Laboratory Animal Research Center, Aichi Medical University, Nagakute, Aichi 480 1195, Japan
J Biol Chem 282:15578-88. 2007..Thus, despite the presence of three closely related 6-O-sulfotransferase genes in the mouse genome, HS6ST-1 is the primary one used in HS biosynthesis in most tissues...
- Evolution of the interhaemal barrier in the placenta of rodentsA M Mess
Department of Research, Museum of Natural History, Leibniz Community, Berlin, Germany
Placenta 30:914-8. 2009..In contrast the second clade shows multiple character transformations...
- Defective deep placentationYee Khong
SA Pathology, North Adelaide 5006, Australia
Best Pract Res Clin Obstet Gynaecol 25:301-11. 2011Defective deep placentation is characterised by defective remodelling of the utero-placental arteries...
- Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentationC D MacCalman
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
Am J Reprod Immunol 39:96-107. 1998..The cadherins are a gene superfamily of calcium-dependent cell adhesion molecules. To date, the role(s) of the cadherins in human implantation remains poorly defined...
- Trophoblast glycogen cells differentiate early in the mouse ectoplacental cone: putative role during placentationRenato Borges Tesser
Department of Histology and Structural Biology, Medical School of the Federal University of São Paulo, Sao Paulo, SP, Brazil
Histochem Cell Biol 134:83-92. 2010..of mouse GCs in EPC and their relationship with blood cells and trophoblast giant cells (TGCs) during placentation. Implantation sites (E5.5-E12...
- Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gammaYuxiang Hu
Department of Obstetrics and Gynaecology, University of British Columbia, 2H30 4500 Oak Street, Vancouver, BC, Canada
J Immunol 177:8522-30. 2006Abnormal placentation results in either inadequate (consequences: recurrent miscarriage, intrauterine growth restriction, and preeclampsia) or overzealous (consequences: placenta accreta, increta, and percreta) placentation...
- Predictors of Pregnancy Outcome in SLE and APSJane E Salmon; Fiscal Year: 2012....
- Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy anHeather R Burkin; Fiscal Year: 2012..Defining the integrin- mediated signaling pathways that regulate stretch induced activation of the uterine myometrium will have important implications for treating preterm and post term labor. ..
- Integrin Regulation of Stretch-Activated Myometrial Signaling During Pregnancy anHeather R Burkin; Fiscal Year: 2013..Defining the integrin- mediated signaling pathways that regulate stretch induced activation of the uterine myometrium will have important implications for treating preterm and post term labor. ..
- Apoptosis and Trophoblast FusionNEAL STEWART ROTE; Fiscal Year: 2010..Defective placentation may result from exogenous environmental or maternal factors or from inborn genetic anomalies...
- Pluripotent Stem Cells: Modeling syncytiotrophoblast development and pathogenesisDanny J Schust; Fiscal Year: 2013..models of early placental development are essential if we are to better understand and treat diseases of poor placentation. The first goal of this proposal is to generate STB and its mononucleated precursors from human embryonic stem ..
- Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine FetusesKenneth L White; Fiscal Year: 2011..Both spontaneous abortion and preeclampsia, which is associated with abnormal placentation, occur at increased frequency in human and bovine pregnancies established by assisted reproductive technologies ..
- Role of the Renin-Angiotensin system in placental insufficiencyEugenia Mata-Greenwood; Fiscal Year: 2013..In addition, the outcomes of this proposal will shed light into the role of RAS genetics in pregnancy outcomes and will provide the scientific community with a novel animal model to study the genetics of placental insufficiency and PE. ..
- The Effects of Ethanol on Microtubules during Mouse Pre-implantation DevelopmentYixian Zheng; Fiscal Year: 2012..will allow us to establish a specific mechanism for the ethanol-induced impairment of implantation and placentation. PUBLIC HEALTH RELEVANCE: Fetal Alcohol Spectrum Disorders affects as many as 9 out of 1,000 pregnancies in the ..
- Angiogenic factors, abnormal placentation and adverse pregnancy outcomesSarosh Rana; Fiscal Year: 2013..The significance and role of these proteins in normal pregnancy and placentation is not known...
- Role of SATB in placental developmentMohammad A K Rumi; Fiscal Year: 2013..Revealing the fundamental regulators of TS cells will greatly expand our understanding of placental morphogenesis and the pathophysiology of placenta-associated disorders. ..
- Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics?Margareta Pisarska; Fiscal Year: 2013..placenta previa, preterm delivery, and perinatal mortality, many of which may be attributed to abnormalities of placentation and trophoblast differentiation in the first trimester, and also have increased risks for major structural ..
- Fetal HCMV Infection: Role of the Human PlacentaLENORE PALMA PEREIRA; Fiscal Year: 2013..To study the molecular mechanisms in vivo, we developed a novel model of human placentation in which xenografts of human placental villi (fetal) and decidua (maternal) are implanted in severe-combined ..
- Modeling preeclampsia in mice with inducible placenta-specific gene expressionNihar R Nayak; Fiscal Year: 2012....
- Placental shape features, gestational timing and maternal and infant healthCarolyn M Salafia; Fiscal Year: 2011....
- Role of Maternal Platelets in the Placenta and Pregnancy ComplicationsRashmi Sood; Fiscal Year: 2013..These are much-needed investigations into platelet and coagulation activities at the feto-maternal interface with direct significance for pregnancy disorders. ..
- Effects of fetal bisphenol A exposure on mouse epigenomeMartha Susiarjo; Fiscal Year: 2013..The mouse will be used as a model system in the proposed studies to determine the potential etiology of human diseases with underlying environmental causes. ..
- The Viral Life Cycle of Human Endogenous Retrovirus Type KDerek Dube; Fiscal Year: 2013..abstract_text> ..
- Fetal Programming and Environmental Exposures: Implications for Prenatal Care andJeffrey A Whitsett; Fiscal Year: 2012..effect on the trajectory of prenatal development and pre-term birth, including the effects on: implantation;placentation;organogenesis;and neonatal health, and how to combat these effects;(ii) foster and highlight the research ..
- The role of CEACAM1 in CMV pathogenesis in the human placentaTakako Tabata; Fiscal Year: 2012..This project addresses molecular mechanisms of viral damage that impairs functions of the human placenta and could identify novel proteins with clinical importance for development of diagnostic and therapeutic strategies. ..
- Human Cytomegalovirus-Induced Inhibition of Cytotrophoblast InvasionCINDY ANNE MORRIS; Fiscal Year: 2012..during early first trimester pregnancy resulting in impaired remodeling of maternal spiral arteries and shallow placentation. Preliminary studies demonstrate that HCMV infection of first trimester EVT results in inhibition of EVT ..
- Incorporation of Endothelial Progenitor Cells into Placental VaculatureGreg A Johnson; Fiscal Year: 2013....
- GATA Factor Function in TrophoblastSoumen Paul; Fiscal Year: 2013..We will also determine whether GATA3 have differentiation stage specific target genes. ..
- STUDIES OF UTEROPLACENTAL CIRCULATIONCHARLES RICHARD ROSENFELD; Fiscal Year: 2013..the ovarian cycle, contributing to the rise in UBF and the increased likelihood of successful implantation and placentation;2) what is the pattern of BKCa expression in the fetal umbilicoplacental circulation during pregnancy and does ..
- Molecular and Cellular Controls of Placental MetabolismYoel Sadovsky; Fiscal Year: 2013..Our findings may pave the way to clinical research into disease biomarkers, therapeutics and prevention. ..
- Therapeutic Antibodies for CMVWILLIAM ROBERT USINGER; Fiscal Year: 2013..The final deliverable from this project will be an IND-ready native human therapeutic antibody to HCMV, which is highly effective at preventing infection of all relevant cell types by a broad range of HCMV strains. ..
- The Function of the Mia3 Gene in Murine PlacentationAnn E Sutherland; Fiscal Year: 2012....
- Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskRobert M Silver; Fiscal Year: 2013..The Nulliparous Network offers an opportunity to address these health disparities. ..
- Placental morphology and serum biomarkers to predict adverse pregnancy outcomeNadav Schwartz; Fiscal Year: 2013....
- FLOW EFFECTS ON ENDOTHELIAL/TROPHOBLAST INTERACTIONGordon C Douglas; Fiscal Year: 2013..Aim 4 determines whether MUC1 modulates ER function by regulating the intracellular localization of ERs. The final aim uses an optical trap to determine whether cell surface MUC1 responds to directly applied force. ..
- ACE2 Deficiency: A new model of maternal and fetal growth restriction.Liliya M Yamaleyeva; Fiscal Year: 2013..the presence of ACE2 in human placenta and maternal stromal tissue in normal pregnancy suggesting its role in placentation in established pregnancy...
- ERV3 Control of Human PlacentationNEAL STEWART ROTE; Fiscal Year: 2013..Activation of the [unreadable]-hCG promoter may occur secondary to cAMP-dependent transcription factors or directly if ERV3 Env is a transcription factor. Studies will evaluate both potential processes. ..
- FUNCTIONS OF PREGNANCY SPECIFIC GLYCOPROTEINSGabriela S Dveksler; Fiscal Year: 2010..Psg-like proteins are only found in species with hemochorial placentation, in which the maternal blood is in direct contact with fetal tissues...
- Integrating Environmental Cues at the Maternal-Fetal Vascular InterfaceEmin Maltepe; Fiscal Year: 2013..and a human placenta tissue bank to test the hypothesis that atypical HIF-target genes regulate mouse and human placentation, and that this process is disrupted in PE...
- Adrenomedullin Signaling at the Maternal-Fetal InterfaceKathleen M Caron; Fiscal Year: 2013..both maternal and fetal sources of AM signaling are important for orchestrating appropriate implantation and placentation that are required for normal fetal growth...
- Origins and Biological Consequences of Human InfertilityLinda C Giudice; Fiscal Year: 2013..abstract_text> ..
- A Novel Model for Assessing the Effects of BPA Exposures on Human PlacentationSusan J Fisher; Fiscal Year: 2013..Similarly, studies in animals suggest that this environmental chemical disrupts placentation, which results in impaired intrauterine growth...
- Effects of Xenobiotics on CYP26 Activity and Retinoic Acid HomeostasisNina Isoherranen; Fiscal Year: 2012..This proposal aims at characterizing interactions between xenobiotics and retinoic acid metabolizing CYP26 enzymes that alter retinoic acid metabolism and clearance and can lead to adverse effects. ..
- Regulation of Trophoblast Proliferation and Invasion by Pluripotency Factor LIN28QUINTON ALEXANDER WINGER; Fiscal Year: 2012..gene regulatory mechanism, LIN28, in trophoblast cells to determine if disrupted regulation produces defective placentation and poor trophoblast invasion...
- Prepregnancy Phenotype and Predisposition to PreeclampsiaIRA MARK BERNSTEIN; Fiscal Year: 2013..In contrast to the view that abnormal placentation results in the release of one or more placental toxins leading to maternal endothelial injury and systemic ..
- The Genomic and Functional Consequences of Trophoblast AneuploidyY KATHERINE BIANCO; Fiscal Year: 2013..Dr. Fisher's group studies human placentation and stem cell biology. In her proposed mentor's lab, Dr...
- Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskHyagriv N Simhan; Fiscal Year: 2013..Because nulliparas are a large proportion of pregnant women, understanding the mechanism for future prevention of preterm birth and other related adverse pregnancy outcomes will have a significant public health impact. ..
- Dynamic contrast-enhanced MRI of placental circulationAntonio Frias; Fiscal Year: 2013....
- Prenatal Smoking, Maternal &Fetal Genetic Variation &Risk of PreeclampsiaStephanie M Engel; Fiscal Year: 2012..by applicant): The etiology of preeclampsia remains unknown, but is hypothesized to result from abnormal placentation. One of the most common complications of pregnancy, with US incidence rates between 2 per cent and 7 per cent ..
- Mechanisms of Preeclampsia: Impact of ObesityCarl A Hubel; Fiscal Year: 2012..ADMA;an endogenous inhibitor of nitric oxide synthase) is also the milieu we suggest interacts with poor placentation to promote the endothelial dysfunction of PE...
- HIF-1 Alpha Regulation of Trophoblast Differentiation in VivoThomas L Brown; Fiscal Year: 2013..Understanding how oxygen sensing regulators control normal placental development will help us understand how pregnancy-associated disorders arise, can be detected, and treated. ..
- The Role of Leptin in Placental DevelopmentLaura Clamon Schulz; Fiscal Year: 2011..abstract_text> ..
- GENETIC COMPLEMENTATION OF A MOUSE MODEL FOR PWSJames L Resnick; Fiscal Year: 2010..We anticipate that this research will significantly contribute to understanding the roles of individual genes in complex PWS traits, refine mouse models of the disease, and provide new insights into growth and obesity. ..
- A longitudinal study of loss of imprinting in the placentaRonald Wapner; Fiscal Year: 2012..of these obstetrical disorders have their origins in an early intrauterine environment associated with aberrant placentation and trophoblast invasion...
- Preterm Delivery and Maternal Cardiovascular Disease RiskClaudia B Holzman; Fiscal Year: 2013..to CVD and that inflammation, dyslipidemia and thrombogenesis converge in pregnancy to compromise placentation and/or maternal vascular integrity among a subset of women who deliver preterm...
- Novel Ubiquitin Dependent Pathways Regulating Neural Tube Closure &PlacentationIrene E Zohn; Fiscal Year: 2013..We identified a novel ubiquitin ligase that plays a critical role in neural tube closure and placentation. Our goal is to understand how regulation of protein function by this novel ubiquitin ligase regulates ..
- A Primate In Vitro Implantation ModelThaddeus Golos; Fiscal Year: 2009..The development of new models with which we can investigate the early formation of the human placenta will be a major step in improving maternal-fetal health. ..
- Use of OET to assess mouse preimplantation quality for uterine transferMAURICE MARCEL GARCIA; Fiscal Year: 2013....
- Embryotropic actions of follistatin: mechanisms and translational relevanceGeorge W Smith; Fiscal Year: 2013....
- TROPHOBLAST DIFFERENTIATIONMichael J Soares; Fiscal Year: 2013DESCRIPTION (provided by applicant): Hemochorial placentation occurs in many mammalian species including primates and rodents...
- Aspen Perinatal Biology ConferenceLoren P Thompson; Fiscal Year: 2010....
- Maternal Genetic Variation and Risk of Adverse Pregnancy OutcomesStephanie M Engel; Fiscal Year: 2010..The priority pathways we have identified bear relevance to the period of placentation, which is a period of development at which these outcomes may be etiologically linked...
- Sirt1-PPARgamma signaling in placental development and fetal growth disordersMana M Parast; Fiscal Year: 2013..growth has been associated with disorders of trophoblastic differentiation and function during early events in placentation, which lead to chronic feto-placental hypoxia...
- Predictors of Dietary Quality in Low-Income Pregnant WomenEileen R Fowles; Fiscal Year: 2010..More effective targeted strategies initiated within this narrow window of time may reduce the number of low birth weight infants and improve obstetrical outcomes. ..
- The Colorado Building Interdisciplinary Research Careers in Women's Health PrograNanette F Santoro; Fiscal Year: 2013..Pregnancy: placentation, lactation, fetal/neonatal programming, 2. Immunology/Rheumatology/Inflammation and 3...
- A singular opportunity to determine the evolutionary genetics of retroviral invasALFRED LOUIS ROCA; Fiscal Year: 2013..Endogenous retroviruses (ERVs) comprise ca. 8% of the human genome, where they play a role in placentation and in a number of diseases...
- Interruption of maternal-fetal transmission of HIVJoseph M McCune; Fiscal Year: 2012..in the context of the SIV-infected rhesus macaque, a well-developed model with unique similarities to human placentation and HIV infection...
- Localizing Maternal and Fetal Message in Translation of Preeclampsia Candidate GeSandra A Founds; Fiscal Year: 2013..This impedes our ability to interpret the maternal versus fetal contributions to placentation or pathogenesis...
- Transcriptional Control of Human Placental DifferentiationStuart Handwerger; Fiscal Year: 2013..new insights into the molecular mechanisms of placental differentiation and the pathogenesis of the defective placentation in preeclampsia and IUGR...
- REGULATION OF MHC GENES IN TROPHOBLASTDOUGLAS ANTCZAK; Fiscal Year: 1999..Our proposed studies of equine pregnancy are, therefore, likely to shed light on mechanisms that operate in human pregnancy. They may also have relevance to MHC gene regulation in tumor growth and transplantation biology. ..
- Dissociating hypoxia from pathology in preeclampsia and*Stacy Zamudio; Fiscal Year: 2007..The advantage of this unique in vivo model is an unparalleled potential to elucidate the underlying pathological causes of preeclampsia and/or IUGR while controlling for the effects of placental hypoxia. [unreadable] [unreadable]..
- The Role of Leptin in Placental DevelopmentLaura Schulz; Fiscal Year: 2009..Second, this project will increase our understanding of the ways in which maternal nutrition during pregnancy, may influence placental development, and even adult health.; ..
- Primate Endometrial Responses to Placental MHC Class I MoleculesThaddeus Golos; Fiscal Year: 2009....
- Misregulation of apoptosis in cloned pig embryosHeide Schatten; Fiscal Year: 2007..Insufficient placentation is the primary cause for cloned fetal loss...
- Trophoblast Selectins and Their Uterine Mucin LigandsSusan Fisher; Fiscal Year: 2006..adhere to and then invade the uterine wall is an integral component first of implantation and subsequently of placentation We have a longstanding interest in the adhesive properties of the human mononuclear Tbs, termed ..
- IMMUNE TROPHOBLAST INJURYKeith McCrae; Fiscal Year: 1992..and preeclampsia--three diseases in which deficient trophoblast-mediated PA activity may result in inadequate placentation and subsequent placental ischemia. Finally, Dr...
- Novel 3-D Model of Placental Cytomegalovirus InfectionCindy Morris; Fiscal Year: 2006..maternal-fetal interface during pregnancy, and 4) the molecular mechanism(s) that regulate the effect of CMV on placentation and pregnancy outcome...
- Mechanisms of Arsenic Toxicity in Vascular DevelopmentJ Douglas Coffin; Fiscal Year: 2003..deformations and developmental anomalies in other systems and vascular abnormalities often form the basis for placentation defects linked to miscarriage...
- Gap Junctions in Placental DevelopmentStephen Lye; Fiscal Year: 2004..This novel investigation integrates the experience and efforts of three laboratories, each recognized internationally for their independent investigations on placental development. ..
- Transcriptional Control of Placental DevelopmentYaacov Barak; Fiscal Year: 2007..These aims will provide valuable insights into the regulation of developmental processes in the placenta, improving our understanding of health and disease processes of the fetus and the pregnant mother. ..