The other incidences of early onset Alzheimer’s, however, share the same traits as the ‘late onset’ form of Alzheimer’s disease, and little is understood about how diagnosis of alzheimer’s disease pdf starts. Non-familial early onset Alzheimer’s can develop in people who are in their thirties or forties, but that is extremely rare. The majority of people with early-onset Alzheimer’s are in their fifties or early sixties.
In this sense, the disease was co-discovered by Kraepelin and Alzheimer, who worked in Kraepelin’s laboratory. Because of the overwhelming importance Kraepelin attached to finding the neuropathological basis of psychiatric disorders, Kraepelin made the decision that the disease would bear Alzheimer’s name. It accounts for approximately half the cases of early-onset Alzheimer’s disease. Non-familial cases of AD are referred to as “sporadic” AD, where genetic risk factors are minor or unclear.
While early-onset familial AD is estimated to account for only 3. Currently, the early-onset familial AD gene mutations guide the vast majority of animal model based therapeutic discovery and development for AD. It is invariably fatal, generally within ten years of the first signs. As the disease progresses the patient exhibits more serious problems, becoming subject to mood swings and unable to perform complex activities such as driving.