In this chapter will be highlight some important historical facts of
tuberculosis treatment and drug development, such as theories, studies and treatment of
TB between 17-20th Century, historical aspects of TB drug discovery, side effects,
fixed-dose combinations, causes of the resurgence of TB, AIDS, multi-drug-resistant
tuberculosis (MDR TB) and extensive-drug- resistant (XDR).
Tuberculosis, Mycobacterium tuberculosis, drugs, treatment, fixeddose
combinations, multi-drug-resistant tuberculosis (MDR TB), extensive-drugresistant
tuberculosis (XDR TB), natural products, synthesis, AIDS, theories,
Instituto de Tecnologia em Fármacos - Farmanguinhos, FioCruz - Fundação Oswaldo Cruz, R. Sizenando Nabuco, 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil.