Simply put, freeze-drying is the removal of water from a frozen product using a process called sublimation. Sublimation occurs when a frozen liquid transforms directly to a gaseous state without passing back through the liquid phase. The process of freeze-drying consists of three phases: prefreezing, primary drying, and secondary drying.
Food items that are freeze-dried must first be prefrozen below its eutectic temperature, or simply put, freezing the materials (solute) that make up the food. Although a product may appear to be frozen because of all the ice that is present, in actuality it is not completely frozen until all of the solute is frozen as well.
After prefreezing, ice must be removed from the product through sublimation. This requires careful control of two parameters; temperature and pressure. The rate of sublimation depends on the difference in vapor pressure of the product compared to the vapor pressure of the ice collector. Molecules move from the higher pressure sample to the lower pressure sample. Since vapor pressure is related to temperature, it is also necessary for the product temperature to be warmer than the ice collector temperature.
After primary drying, all ice has sublimated but some liquid is still present in the product. Continued drying is necessary to remove the remaining water. The process for removing this excess water is called isothermal desorption. The excess water is desorbed from the product by making the product temperature higher than the ambient temperature.
During the entire freeze-drying process, the exact freezing methodology and proper storage is very important.