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The rage and treatment virus used to provide for it
The rage, a word derived from the ancient Indian roots: "Rabh", which means violent behavior, is a disease recognized since ancient times, probably older than the human race;It was considered as the action of supernatural forces on man and other mammals, mainly the dog.(1)
As Leonardo says, ’’ The pain of the irritable dog bite became more in the heat time, which was known as ‘’ Canicicle ‘’ due to the constellation of this can over the sun.’’
Omar Khayyam (1017-1123) in his work Rubaiyat, with an abundance of images, in a box recounts the brevity of life and the fatal destiny that follows the bite of a dog. Jerónimo Falstoro (sixteenth century), said that rage could not be contracted by any kind of contact, except when the skin has been broken by a dog’s bite. Gruner (1881) recommended the inoculation of saliva of sick dogs to healthy animals, as a half diagnosis of the disease. The French biologist chemist, Louis Pasteur establishes, through his investigations, the principle of preventive vaccines, inoculating mikes of attenuated virulence and culminates with the use of the anti -rabies vaccine in 1885.(1)
Cecilia says, “ who discovered the anti -rabies vaccine was the chemist Lois Pasteur, since he wanted to help people suffering from this virus, so he focused on making such a vaccine that I can fight in residing with this, and in1988 this vaccine began to be used.’’
Antirrabic treatment gave rise to a new scientific revolution, the so -called «Pasteurian revolution. This science model crystallized in the foundation of the Pasteur Institute, an institution with specific ideology and whose basic objectives were the elaboration of the anti -rabic vaccine and research, mainly in aspects of microbiology related to public health.
In Peru in 1983 the first meeting of directors of national rabies control programs in Guayaquil, Ecuador in which the strategies of the Action Plan for the Elimination of Urban Rabies were approved.
The rabies virus is assigned to the Rhabdoviridae family (from the Greek irhabdos = cane), which includes five viruses, all serologically related to the rabies virus;Electronic microscopy is defined as a bullet, composed of a core of Helical RNA, 23 of a unique strip, with RNA polymerase.
The virus does not tolerate the pH below 3 or above 11;It is inactivated by ultraviolet light, sunlight, desiccation, exposure to formaldehyde, tripsin, b propionolactone and detergents.7 Once the virus is acquired, it is located in receptors that seem to be of cholinergic type, 26,27 demonstrating experimentally that after viral inoculation, the antigen can be detected by immunofluorescence, in positive colinesterase sites.
According to Juan.” Rabia is one of the diseases over time has been forgotten in scientific development and this is affected by poorest rural communities, especially those children and adolescents under 15 years of age, but children are less than whatThey are mostly affected ”
90% of cases of human rabies in the world are due to the bite of sick dogs, although infection can also occur through saliva contact with mucous membranes and injuries caused by scratches.
According to a study by WHO in 2004, it is estimated that there are about 55.000 deaths annually for this disease worldwide, the vast majority of them in rural areas of Asia and Africa. About 10 million people receive treatment every year after being exposed to suspected animals of rage.
From the epidemiological point of view, despite the deadly outcome of the disease, rage in cities and populated in various parts of the world is maintained by the existence of a considerable proportion of susceptible dogs. The great density of dogs and their high annual reproduction rate are important factors in the epizootics of canine rabies in Latin America and other geographical regions. Other aspects to take into account, in the maintenance of the virus, is the long period of incubation of the disease in some dogs and the different elimination, in time and quantity of the pathogen, through saliva. The virus advances centripetally by nerve laces at a speed of 3 mm per hour, experimentally proven.
Juan says.(3) ” As we already know rabies in a fatal virus that focuses more that is caused by dogs, the persistence of this virus is due to abortive rage and carriers, this virus causes it to violate natural defensesof our body, thus giving this virus act within it and can expand.’’
Rabies being a fatal disease, the persistence of it in nature is due to the existence of the so -called abortive rage and that of bearers. An aspect that has raised controversy for a long time is the possible existence of carriers, that is, clinically normal animals that eliminate viruses by saliva. Upon recent times, there was no reliable evidence that such a state of rating bearer existed. However, in Ethiopia and India, the saliva virus of several asymptomatic dogs and for very prolonged periods has been isolated and for very prolonged periods.
- Leonardo Ll, Eduardo Op. Rabia: viral infection of the central nervous system. 2009;10 (3): 212-9.
- Cecilia Ana, Romo Rde. Antirrabic: The Mexican case *. : 291-316.
- Pasteur l. THE RACHING: Current perspective. 2012;68 (4): 201-2.