Flashcards in Organization of the nervous system Deck (40):
Dopamine affects which receptors?
Norepinephrine affects which receptors?
Beta 1 receptors
Epinephrine affects which receptors?
Nonselective, hits all receptors
Which receptor is the cardiovascular control system in the medulla?
Drug that is best alpha 1 receptor agonist?
Drug that is best B1 receptor agonist?
Drug that is best B2 receptor agonist?
Norepinephrine effect on pulse rate?
Norepinephrine effect on blood pressure?
Norepinephrine effect on peripheral resistance?
Epinephrine effect on pulse rate?
Epinephrine effect on blood pressure?
Epinephrine effect on peripheral resistance?
Isoproterenol effect on pulse rate?
Isoproterenol effect on blood pressure?
Isoproterenol effect on peripheral resistance?
Uses for Epinephrine?
Phenylephrine is a substrate for what?
Mydriasis without cycloplegia
Main functional trait of a1 receptor agonist imidazoline?
Basic nature of imidazoline ring causes compounds to exist in ionized form at physiologic pH, not absorbed well so they work locally
Where does clonidine bind to receptors?
a2 receptors in the nucleus of the solitary tract in the medulla
Uses for clonidine?
How do a2 adrenergic agonists reduce blood pressure?
They reduce sympathetic output from the brain
Which a2 receptor agonist has the shortest half life?
Guanfacine is used to treat which behavioral disorder?
a2 receptor agonist we talked about that works as a prodrug?
Tizanidine is used to treat what?
Adverse effects of a2 receptor agonist?
Sodium and water retention
Main function of isoproterenol?
Albuterol is what kind of agonist?
Beta 2 receptor agonist
Albuterol used to treat what?
Problem with using Salmeterol for acute asthma symptoms?
It takes 20 minutes to activate
+ enantiomer of Dobutamine affects what receptors?
B1 receptor agonist, a1 antagonist
- enantiomer of Dobutamine affects what receptors?
a1 agonist, potency of B receptors reduced 10X
Use for Dobutamine?
Acute heart failure/shock
Amphetamines have what effect on sympathetics?
Reverse the NE transporter
Coccaine has what effect on sympathetics?
Blocks the NE transporter
Clinical uses for Amphetamines?
How does D(-)Ephedrine work?
Direct agonist activity at adrenergic receptors