The nematode <i>Caenorhabditis elegans</i> expresses the <i>ten-1
</i> gene that encodes teneurin. TEN-1 protein is expressed throughout the life of <i>C. elegans</i>. The loss of <i>ten-1
</i> function results in embryonic and larval lethality, highlighting its importance for fundamental processes during development. TEN-1 is expressed in the epidermis and neurons. Defects in neuronal pathfinding and epidermal closure are characteristic of <i>ten-1
</i> loss-of-function mutations. The molecular mechanisms of TEN-1 function in neurite outgrowth, neuronal pathfinding, and dendritic morphology in <i>C. elegans</i> are largely unknown. Its genetic redundancy with the extracellular matrix receptors integrin and dystroglycan and genetic interactions with several basement membrane components suggest a role for TEN-1 in the maintenance of basement membrane integrity, which is essential for neuronal guidance. Identification of the <i>lat-1
</i> gene in <i>C. elegans</i>, which encodes latrophilin, as an interaction partner of <i>ten-1
</i> provides further mechanistic insights into TEN-1 function in neuronal development. However, receptor-ligand interactions between LAT-1 and TEN-1 remain to be experimentally proven. The present review discusses the function of teneurin in <i>C. elegans</i>, with a focus on its involvement in the formation of receptor signaling complexes and neuronal networks.