Domenico Ghirlandaio (1449 - 11 January 1494) was an Italian Renaissance painter from Florence. Among his many apprentices was Michelangelo.
Ghirlandaio's full name is given as Domenico di Tommaso di Currado di Doffo Bigordi. The occupation of his father Tommaso Bigordi and his uncle Antonio in 1451 was given as 'setaiuolo a minuto,' that is, dealers of silks and related objects in small quantities. He was the eldest of six children born to Tommaso Bigordi by his first wife Mona Antonia; of these, only Domenico and his brothers and collaborators Davide and Benedetto survived childhood. Tommaso had two more children by his second wife, also named Antonia, whom he married in 1464. Domenico's half-sister Alessandra (b. 1475) married the painter Bastiano Mainardi in 1494.
Domenico was at first apprenticed to a jeweller or a goldsmith, most likely his own father. The nickname Il Ghirlandaio (garland-maker) came to Domenico from his father, a goldsmith who was famed for creating the metallic garland-like necklaces worn by Florentine women. In his father's shop, Domenico is said to have made portraits of the passers-by, and he was eventually apprenticed to Alessio Baldovinetti to study painting and mosaic.