IntroductionSuperoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been dentified. Among these, ec SOD, also known as extracellular SOD or SOD3, is a heparin-binding multimer of disulfide-linked dimers. SOD3 is primarily expressed in lungs, vessel walls and airways (4) where it can be found extracellularly in interstitial spaces.References:
1) Kuninaka, S. et al. (2000) Br. J. Cancer. 83:928-934.
2) Strange, R.W. et al. (2003) J. Mol. Biol. 328: 877-891.
3) Weisiger, R. A., and Fridovich, I. (1973) J. Biol. chem. 248: 3582-3592.
4) Enghild, J. J. et al. (1999) Biochem J. 317:51-57.
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