is the most common of these conditions and often presents in early childhood during the first year of life.
Ichthyosis is derived from the Greek word for fish, "ichthys." Ichthyosis vulgaris
, the most common, often presents in early childhood during the first year of life.
Owing to atopic dermatitis, diaper dermatitis, urticaria and dyshidrotic eczema, xerosis, and ichthyosis vulgaris
, 5 (19.2%) cases were referred to the dermatology polyclinic.
Vesicular lesions confined to hands and feet have been reported in two adults in a study from South India.4 Exacerbation of existing dermatoses has been described in CKG.4,11 Exacerbation of psoriasis, ichthyosis vulgaris
, melasma and darkening of melanocytic nevi was observed in this study.
Several studies have shown that the c.3321delA mutation was associated with various AD-associated phenotypes, most of which are related to dry skin phenotypes, including xerosis, ichthyosis vulgaris
(IV), and palmar hyperlinearity.[sup] In this study, we used high-resolution melting analysis (HRMA) with unlabeled probe for the detection of c.3321delA mutation in Chinese AD patients and investigated the genotype-phenotype correlation between c.3321delA and atopic characteristics.
About 1 in 10 individuals of European ancestry carry one FLG null mutation, meaning that such individuals have only about half of the normal FLG protein in their skin, resulting in dry skin and/or ichthyosis vulgaris
and a high risk for AD.
A study of 100 ama X-hosa children in South Africa with severe AD and ichthyosis vulgaris
symptoms revealed no FLG mutations.
Filaggrin genotype in ichthyosis vulgaris
predicts abnormalities in epidermal structure and function.