The gut microbiota (GM) is currently considered as a pathogenic factor in a number of diseases. It is known that some gastrointestinal diseases cause a high risk of developing urolithiasis. The study gives modern data demonstrating the influence of the GM, in particular Oxalobacter formigenes, on the formation of oxalate kidney stones. The relationship between the presence of inflammatory bowel diseases and the use of antimicrobial drugs with oxalate homeostasis was demonstrated, methods for correcting the GM in patients with urolithiasis, including the use of probiotics and diet therapy, were analyzed. The studies presented in the article demonstrate that the correction of the GM can be considered as a therapeutic goal and be an actual component of the complex treatment and metaphylaxis of nephrolithiasis.
Implication for health policy/practice/research/medical education:
Urolithiasis is a common disease that affects patients of all ages and significantly reduces the quality of life. With technological advancements and growing expertise, nephrolithiasis can be diagnosed more easily than before. A better understanding of the relationship of this disease with the intestinal microbiota discussed in this study will lead to improved metaphylaxis and proper treatment of nephrolithiasis. This, in turn, will reduce the prevalence of kidney stones.
Please cite this paper as: Sturov NV, Popov SV, Ivanov ZA, Rusanova EI, Kobylyanu GN. State of the gut microbiota in oxalate nephrolithiasis. J Renal Inj Prev. 2023; 12(1): e32060. doi: 10.34172/jrip.2022.32060.