SLE is known around the world as a skin irritant. In fact, the primary purpose why SLS is used in clinical studies is to cause skin irritation that can be used to identify the properties of other chemicals. Another clinical report states that some in depth studies have indicated that SLS enters and maintains residual levels in the heart, liver, lungs and brain from skin contact. Which makes our regular use of shampoos, soaps, cleansers and toothpastes with the said chemicals a potential health threat.
SLE and SLES also cause hormonal imbalance, eye irritation, protein denaturing and carcenogenicity. The last two are related that even as these two toxic substances denatures proteins, it heightens the risk of potential to cause pre-cancerous conditions.