The research at Children’s Hospital Los Angeles has undergone and lead to the rise of new liver tumor hepatocellular malignant neoplasm-NOS (HEMNOS). It has two characteristics of the pediatric liver cancer hepatoblastoma (HB), hepatocellular carcinoma (HCC) seen in adults.
HEMNOS had been said to have a very poor course of medication. The research organized and studied the cases of 11 patients with liver cancer age group of 4 to 15 from 2000-2016.
The patients received HB-targeted chemotherapy and complete surgical resection. However, all the patients survived and achieved considered high risk.
Telomerase DNA protein is cause for survival of cancer cells
The doctors performed analyses to define unique group of tumors. The review of pre-chemotherapy revealed six tumors. Overlapping tissue features had predominant HB histology, along with HCC-like histology and HB histology.
Investigators also examined the expression of the telomerase gene (TERT), a protein in DNA complex crucial for the survival of cancer cells. Also found TERT expression in nine of the 11 cases.
In addition the researchers organize a study to know the genomic difference of the HEMNOS tumor. And differentiate both classic hepatoblastoma and hepatocellularcarcinoma to get into the pathophysiology of this cancer.