Celiac.com 10/24/2016 - A team of researchers led by Mahmoud A Ghannoum, PhD, professor and director of the Center for Medical Mycology at Case Western Reserve and University Hospitals Cleveland Medical Center, has made a breakthrough in understanding Crohn's disease.
For their study, the team analyzed fecal samples from 20 Crohn's patients, and from 28 Crohn's-free patients from nine families, and of 21 Crohn's-free patients from four nearby families. The team found that people with Crohn's disease showed strong fungal-bacterial interaction. Specifically, in Crohn's, two bacteria, Escherichia coli and Serratia marcescens, acted in unison with the fungus Candida tropicalis.
Family members with Crohn's showed substantially higher numbers of all three microbes, as compared to their healthy relatives, suggesting co-action between the bacteria and fungus in the gut. The team's lab tests confirmed that the three work together by E. coli cells fusing to the fungal cells, while S. marcescens acts as a bridge to connect the microbes. This produces what is called a biofilm, a thin, slimy layer of microorganisms that, among other things, coats part of the intestinal tract, triggering the inflammation seen in Crohn's disease.
Researchers had previously found the fungus in mice with Crohn's, but this is the first time any fungus has been linked to Crohn's in humans. The study is also the first to document S. marcescens as a main factor in Crohn's.
The team also found that Crohn's patients suffer from substantially reduced numbers of beneficial bacteria, which corroborated earlier study findings. These findings could lead to helpful new treatment approaches to the traditionally stubborn condition that is Crohn's disease.
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