is a condition characterized by hemolytic anemia (when red blood cells are destroyed earlier than normal). Signs and symptoms may include pale skin, fatigue, anemia, jaundice, gallstones, and enlargement of the spleen. The condition is caused by mutations in any of several genes, including the ANK1, EPB42, SLC4A1, SPTA1, and SPTB genes. It is most commonly inherited in an autosomal dominant pattern, but may also be inherited in an autosomal recessive pattern. Different types of hereditary spherocytosis exist and are distinguished by their severity and genetic cause. Depending on severity, treatment may involve folic acid replacement, red cell transfusions, splenectomy, and cholecystectomy. Source: Genetic and Rare Diseases Information Center (GARD), supported by ORDR-NCATS and NHGRI.