Gene expression is the process by which the information encoded in a gene is used to direct the assembly of a protein molecule. The cell reads the sequence of the gene in groups of three bases. Each group of three bases (codon) corresponds to one of 20 different amino acids used to build the protein.
To play the media you will need to either update your browser to a recent version or update your Flash plugin
Gene expression is the process the cell uses to produce the molecule it needs by reading the genetic code written in the DNA. To do this, the cell interprets the genetic code, and for each group of three letters it adds one of the 20 different amino acids that are the basic units needed to build proteins.
Fabio Candotti, M.D.
Senior Investigator, Genetics and Molecular Biology Branch; Head, Disorders of Immunity Section
Dr. Candotti's laboratory studies the molecular basis of inherited disorders of the immune system in order to develop better treatments for these conditions. Currently, for many inherited immune deficiency disorders, the only available therapeutic option is hematopoietic stem cell transplantation (HSCT), an intensive procedure that carries a number of risks. Dr. Candotti is seeking treatment alternatives to HSCT, focusing on gene replacement approaches. His laboratory is developing gene therapies for two rare immune deficiency syndromes, adenosine deaminase (ADA) deficiency and Wiskott-Aldrich syndrome (WAS).