For years, medical professionals and the livestock industry have made great efforts not to overuse antibiotics, but drug-resistant microorganisms continue to thrive.
Hua Wang thinks she knows why: Antibiotic usage is just one of the factors causing resistance, she said.
"Antibiotic resistance is a complex issue. Just targeting one source is not enough to take care of the problem," said Wang, a researcher with Ohio State University's Ohio Agricultural Research and Development Center and an associate professor of food science and technology.
In a special commentary in the Oct. 15, 2011, issue of the journal Applied and Environmental Microbiology, Wang offered an analysis of recent research on the issue. She also co-authored three of the 12 accompanying articles that stemmed from a 2009 conference she organized.
"While most people only think about the kinds of bacteria that directly cause diseases -- what we call pathogens -- the genes causing resistance are in fact carried mostly by 'commensal' bacteria that are otherwise harmless, or even beneficial, but which can be transferred to disease-causing bacteria."
Commensal bacteria are commonly found in such foods as yogurt and cheese and are otherwise pervasive in the environment.
"We now understand that commensal bacteria are the main contributor of antibiotic resistance," Wang said "If you see antibiotic resistance coming in commensal bacteria, you can predict it will transfer to pathogenic bacteria. Once it's in pathogenic bacteria, you're way too late to do much about it. This is a strategic shift in attacking the problem."
In her commentary, "Antibiotic Resistance: How Much Do We Know and Where Do We Go from Here?" Wang offers an overview of the current research on the issue, noting that antibiotic-resistant bacteria "have been found not only in various food products and environmental samples but also in hosts without a history of direct exposure to antibiotics."
In fact, one of the accompanying articles, "Acquired Antibiotic Resistance: Are We Born With It?" finds that infants as young as a few days old commonly develop large numbers of intestinal antibiotic-resistant bacteria. In that study, Lu Zhang, a Ph.D. student in Wang's lab, suggests that antibiotic resistance can be easily transferred from the environment to the baby, particularly from the mother, likely during birth delivery and breastfeeding. Data from his study suggests that even a small amount of antibiotic-resistant bacteria getting into the mouth or nose (through food or other exposure) may significantly grow in the gut even without antibiotic exposure.