Pauline Cafferkey, the Scottish nurse who acquired the Ebola virus while treating patients in Sierra Leone back in December 2014, was flown to a London hospital February 23 with re-emerging symptoms.
This is the third time she has been treated since her initial infection 14 months ago.
Officials from the Royal Free hospital in London told the BBC that Cafferkey is in stable condition and that she will be treated "under nationally agreed guidelines."
Cafferkey's experience points to a troubling fact: We still have a lot to learn about this pernicious virus, and many details remain unknown.
One of the biggest mysteries surrounding the Ebola virus is its ability to hide out in survivors' bodies and evade detection by the immune system.
This "trick" of the virus previously became abundantly clear when Cafferkey was readmitted to a London hospital in October 2015 in "serious condition." That was a full nine months after doctors announced she had made a full recovery from Ebola.
"The virus, several experts said, managed to somehow persist and apparently re-emerged to cause a severe disorder of her central nervous system," The New York Times wrote then. "Her spinal fluid had tested positive for traces of Ebola."
As doctors are poignantly learning, saying a patient is "cured" of the virus doesn't necessarily mean it is completely eradicated from the body. Though it's not clear what symptoms Cafferkey is currently experiencing, other Ebola survivors have suffered lingering symptoms such as vision and hearing loss, seizures, insomnia, and body aches that have persisted for months following infection.
The virus — which is transmitted through infected bodily fluids and can cause severe fever, diarrhea, vomiting, headache, pain, and bruising — kills about half of those who contract it.
As of February, the 2014 Ebola epidemic has killed a staggering 11,316 people. The disease spread quickly through West Africa and caused panic in the US and Europe.
While those who count themselves among the survivors are especially lucky to be alive, many are suffering even after getting better. Doctors are still learning what other nasty health issues can flare up long after defeating the primary, life-threatening infection.
One of the best sources of information we have on these latent symptoms is Dr. Ian Crozier, an American Ebola survivor who contracted the illness while treating patients in Sierra Leone in August 2014.
At an infectious-disease conference in San Diego on October 7, 2015, Crozier detailed some of the bizarre and devastating symptoms he had experienced since his more than 40-day recovery at Emory University Hospital in Atlanta.
The most striking of those symptoms were severe eye issues, which began about 10 weeks after his first symptoms of Ebola and nearly caused him to go blind. A report published in The New England Journal of Medicine on May 7, 2015 described the flotilla of symptoms.
When Crozier was released from the hospital 10 weeks after Ebola onset, the virus was not detectable in his blood and urine but was present in his semen.
He experienced difficulty walking, lower-back pain, inflammation of his Achilles tendon, and pins-and-needles sensations in his lower limbs. Crozier also began to feel burning in his eyes, along with the feeling that something was in his eyes and a sensitivity to light. An eye exam revealed scarring on the inside surface of his eye and a small hemorrhage next to one of the scars in his left eye.
About a month later, these symptoms worsened. His doctors took a sample of the fluid that sits between the cornea and lens and — lo and behold — it tested positive for Ebola.
His vision continued to decline in his left eye, and at one point his eye color even turned from blue to bright green.
"In addition to the color change, I lost pressure in my eye, my eye began getting softer and losing its architecture," Crozier said in a video interview with CNN. "So by the time I flew back to Phoenix, it was like looking through a block of cheese."
Eye problems aren't unusual among Ebola survivors. About 25% of Ebola survivors who have been evaluated by medical doctors have reported changes in vision, according to the Associated Press.
Crozier's vision has since improved after what turned out to be cellular debris that was blocking his line of vision detached from his retina. But according to Live Science, it still isn't back to normal.
Since Crozier was released from the hospital, he has continued to experience severe back pain, ringing in his ears, hearing loss, and cognitive problems such as impaired short-term memory. He also suffered a seizure while attending a wedding in England the summer of 2015, according to Live Science, and has since been put on an antiepileptic drug.
Nina Pham, a Texas nurse who contracted the disease while treating a patient at a Dallas hospital in October 2014, has also had lingering health issues, including hair loss, body aches, nightmares, and insomnia.
Few people survive Ebola, so the disease's long-term effects aren't well studied. But lingering symptoms such as body and joint aches and fatigue are what you'd expect after any serious infection, Jesse Goodman, an infectious-disease expert and a professor of medicine at Georgetown University Medical Center in Washington, D.C., told LiveScience.
Chemicals released by the immune system can make people feel sick, Goodman said, and muscles and tissues could have been injured from the dehydration, malnutrition, and low blood pressure during the disease.
Roughly 13,000 other Ebola survivors are experiencing similar problems as Crozier, Pham, and other survivors. To that end, scientists launched a five-year study in June 2015 that will follow 1,500 Ebola survivors and 6,000 people they were in close contact with.
But not all survivors have had such horrendous lasting effects.
Journalist Ashoka Mukpo was emotionally scarred after contracting Ebola while covering the outbreak in Liberia, but in an interview with CNN he said, "I feel pretty strong physically, psychologically, and spiritually right now." And doctor Rick Sacra, who also contracted Ebola in Liberia, experienced only blurry vision and a bad cough after his recovery at a hospital in Nebraska.
"There is an emerging problem in Ebola survivors," Crozier said in the video interview with CNN. "It will be a varied spectrum — some will be mild, but there will be patients who develop severe complications and who are going blind. You can imagine an Ebola survivor who's already been through their own personal hell ... and then through a lonelier hell in an ETU [Ebola Treatment Unit]," Crozier continued. "It's a story we must pay attention to."