HIV P24 (aa 155 - 321) [His], recombinant protein from E. coli
p24 (HIV1) (AAA44987, 155 a.a. - 321 a.a.) partial recombinant protein with His tag expressed inEscherichia coli .
In 20 mM Tris-HCl, 100 mM NaCl, pH 8.0 (0.1 mM PMSF, 10% glycerol)
2-8°C short term, -20°C long term
Human immunodeficiency virus (HIV) is a lentivirus (a member of the retrovirus family) that causes acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. The four major routes of transmission are unsafe sex, contaminated needles, breast milk, and transmission from an infected mother to her baby at birth (perinatal transmission). Screening of blood products for HIV has largely eliminated transmission through blood transfusions or infected blood products in the developed world.
HIV1 performs highly complex orchestrated tasks during the assembly, budding, maturation and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Capsid protein p24 probably forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.
HIV-1 p24; HIV1 p24; CA; Capsid protein p24; Human immunodeficiency virus 1; Human immunodeficiency virus type 1 p24; Retroviridae; Lentivirus