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Table 6.10. Radionuclide Specific Therapies
||Mechanism of Action
||Blocks thyroid deposition
||Blocks gastrointestinal (GI) absorption and prevents recycling
|Plutonium and transuranics (Americium, Californium, Lanthanum, Curium)
||Acts as chelating agent
||Alkalinizes urine, decreases chances of acute tubular necrosis
||Forced fluids, diuretics
||Oral aluminum phosphate or barium sulfate
||Blocks GI absorption
||Magnesium sulfate lavage
||Stomach lavage, aluminum hydroxide, oral phosphates
||Prevents absorption, blocks cellular deposition
||Gastric lavage, purgatives; penicillamine if severe
||Prevents absorption, acts as chelating agent
Source: National Council on Radiation Protection and Measurements. Management of Persons Accidentally Contaminated with Radionuclides, Report Number 65, 1979. Bethesda, MD. Reprinted with permission.
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