Espostoa guentheriis known from a rather small area is Eastern Bolivia. It occurs in seasonally dry forest vegetation within an inter-Andean valley, often covering a hillside, or forming a cactus forest with other species. The area is dry and hot at times, but wet enough to support leafy trees and shrubs. Espostoa guentheri is quite common where it occurs. Ongoing road construction in the southern end of its range is reducing the population, but there are currently no other known threats. Espostoa guentheri was placed in its own genus Vatricania because it occurs in eastern Bolivia whereas all the Espostoas occur in Peru.