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Human parvovirus B19 (B19) is an erythrovirus and causes anaemia. B19 infection results in not only anaemia but also a variety of symptoms resembling autoimmune diseases.1–3 As B19 is detectable in non-erythroid cells in vivo,4,5 B19 infection is of interest for an understanding of the pathogenesis of autoimmune diseases. We investigated the mode of B19 infection in the bone marrow of patients with rheumatic diseases who had B19 viraemia.
A polymerase chain reaction (PCR) was carried out on peripheral blood samples obtained from 92 febrile adult patients with rheumatic disease in our clinic during 1999–2001 to detect B19 DNA (B19 viraemia); an enzyme linked immunosorbent assay (ELISA) was carried out on serum samples from the patients to detect anti-B19 IgM. Informed consent was obtained from …
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