FVII deficiency is a rare inherited bleeding disorder in which only low levels of factor VII are present in the blood so that the blood does not clot properly after blood vessel injury. It occurs in approximately 1 in 500,000 persons and can affect males and females equally. The frequency and severity of bleeding episodes can be very different between patients with FVII deficiency. Common sites of bleeding are the nasal cavity and gums, muscles and the joints. Uncontrolled bleeding during menstruation, during and after surgery as well as easy bruising also occur. Treatments rely on replacement therapy using recombinant or plasma derived factor VII or prothrombin complex concentrates.
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HQMMA/N7/0914/0067. November 2014.