Memory impairments and other early symptoms of Alzheimer’s are often difficult to differentiate from the effects of normal aging.
The inability to accurately diagnose Alzheimer’s in the early stages makes it difficult for doctors to recommend treatment for those affected until the disease has progressed.
Care for Alzheimer’s is a critical issue as the number of Americans living with the disease will increase from five million in 2014 to as many as 16 million by 2050.
Previous studies have shown that a part of the brain called the hippocampus is important to relational memory — the “ability to bind together various items of an event,” said Jim Monti, Ph.D., of the University of Illinois.
Being able to connect a person’s name with his or her face is one example of relational memory.
“These two pieces of information are stored in different parts of the brain, but the hippocampus ‘binds’ them so that the next time you see that person, you remember his or her name,” Monti said.
As prior studies have shown that people with Alzheimer’s disease often have impairments in hippocampal function, researchers designed a task that tested participants’ relational memory abilities.
Participants were shown a circle divided into three parts, each having a unique design. Similar to the process of name-and-face binding, the hippocampus works to bind these three pieces of the circle together.
After the participants studied a circle, they would pick its exact match from a series of 10 circles, presented one at a time.
People with very mild Alzheimer’s disease did worse overall on the task than those in the healthy aging group, who, in turn, did worse than a group of young adults.
The task also revealed an additional memory impairment unique to those with very mild Alzheimer’s disease, indicating the changes in cognition that result from Alzheimer’s are qualitatively different than healthy aging.
“This unique impairment allows researchers to statistically differentiate between those who did and those who did not have Alzheimer’s more accurately than some of the classical tests used for Alzheimer’s diagnosis,” Monti said.
“That was illuminating and will serve to inform future work aimed at understanding and detecting the earliest cognitive manifestations of Alzheimer’s disease,” Monti said.
“Although this new tool could eventually be used in clinical practice, more studies need to be done to refine the test,” he said.
“We’d like to eventually study populations with fewer impairments and bring in neuroimaging techniques to better understand the initial changes in brain and cognition that are due to Alzheimer’s disease,” Monti said.