Flashcards in Drugs for Inflammation Deck (22):
What is the general action of glucocorticoids?
inhibit AA release and metabolism
What is the action of NSAIDs?
What is the effect of antagonising CysLT1 receptors?
block LTC4 and LTD4 actions. Prevent bronchospasm and nasal congestion
T/F The action of the inducible Cox-2 is not as strong as the constitutive Cox-1
False, Cox-2 can be 100x more potent
What is one reason why tumor cells often cause acute and chronic inflammation
tumors induce Cox-2
Which prostaglandin is most related to inflammation
What prevents us from using prostaglandin as drugs?
too unstable and expensive
T/F Aspirin is indicated for patients with gout
False, although anti-inflammatory, aspirin can compete with the clearance of urea at the kidneys
Why is NSAID useful for gout?
It blocks the action of PGE2, hence reducing inflammation
How does NSAID cause analgesia?
by removing sensitisation from AA products
Why is paracetamol preferred as an antipyretic?
aspirin tends to cause gastric bleeding more so than paracetamol
How does NSAID cause gastric ulcer?
by inhibiting PGE2, it also inhibits the ability to repair gastric mucosa. Without the protective effect of PGE2, there may be acid reaching the gastric lumen
T/F NSAID is an anti-coagulative
T/F low dose aspirin can prevent CV disease
True, because it affects only platelets in the portal circulation, reducing TXA2 but not affecting vascular PGI2
T/F NSAIDs can sometimes cause bronchoconstriction
True, some individuals are hypersensitive, and can overproduce leukotrienes
How is aspirin different to other NSAIDs?
Which drug is Reye's syndrome associated with?
How is paracetamol different to NSAIDs?
it's analgesic, antipyretic, but not anti-inflammatory
What is the theory of COX-2 selectivity?
its hydrophobic pocket for AA is larger than that of COX-1, so it can reduce GIT side effect while retaining efficacy
Why has some COX-2 agents been withdrawn?
they increase CV risk in the long run, because COX-2 is the main contributor of coronary artery integrity
What are the three mechanisms of action of glucocorticoids?