This study will determine whether short term intravenous infusion of vitamins A and E in
patients with abetalipoproteinemia can reverse disease symptoms in these patients.
Abetalipoproteinemia is an inherited metabolic defect that prevents fat-soluble vitamins,
such as A and E, from being absorbed from the intestines into the bloodstream and from being
secreted by the liver. The deficiencies of vitamins A and E can result in severe vision
impairment and a gait disorder. Treatment with megadoses of these vitamins, taken by mouth,
may delay or arrest symptoms, but many continue to progress.
For this study, a single patient with moderately severe eye and neurological defects will be
given essential fatty acids and fat soluble vitamins directly through a vein (intravenously)
using FDA-approved replacements with a fat emulsion and multivitamins containing fat-soluble
vitamins. This route of administration will bypass the digestive tract, where the
absorption problem occurs. The infusions will be given twice a week for one month and then
weekly for another month. Blood tests will be done weekly to measure blood lipids (fatty
acids and other substances), cell counts, and vitamin levels. Eye and neurological
examinations will be done once a month.
Fat-soluble vitamins are normally absorbed from the diet through the gastrointestinal tract
and incorporated into fat-rich particles called chylomicrons made in the intestinal wall.
Chylomicrons are secreted by the intestine into the bloodstream. In a rare lipid metabolic
disorder called abetalipoproteinemia, a defect in the assembly of the fat and vitamin
containing particles prevents the formation of chylomicrons resulting in the malabsorption
of fat and fat-soluble vitamins. A similar assembly defect of fat and fat-soluble vitamins
occurs in the liver and prevents the secretion of these particles. Severe fat-soluble
vitamin deficiency results even despite mega doses of oral fat-soluble vitamins.
Clinically, the subjects develop neurologic and ophthalmologic symptoms similar to those in
Vitamin A and E deficiency. This study is designed to determine whether short-term
intravenous fat-soluble vitamins and fat emulsion can reverse the neurologic and
ophthalmologic complications of fat-soluble vitamin deficiency based on noninvasive
procedures routinely employed in clinical practice.
None provided - protocol is intended for one patient only.