The earliest immigrants to the Americas brought with them a subset of the maternal and paternal DNA lineages present in their Asian source populations. An excellent summary of the distribution of global mtDNA and YDNA lineages can be found here.
The four major Native American founding lineages have been renamed A2, B2, C1, and D1 to distinguish them from closely related lineages in Asia.
A small proportion of mtDNA lineages found in indigenous peoples (<1%) are derived from recent non-native (European or African) admixture (Gonzales et al. 2003; Richards et al. 1996). The majority of these mtDNAs belong to lineage H, the most common mtDNA lineage family in European populations such as Spain and the United Kingdom (Figure 1.3.). The most common mtDNA lineage among Ashkenazi Jews is lineage K (Behar et al. 2004). Lineage L is the most common lineage in African populations.