While postdoctoral fellows at the NIH, Joe Goldstein and Michael Brown were presented with a young patient with familial hypercholesterolemia (FH), a disease characterized by high LDL cholesterol and atherosclerosis. Scientific curiosity along with a desire to help these patients led Brown and Goldstein to dedicate themselves to understanding the biological basis for FH. This video by Youreka Science describes the experiments that led to the Nobel Prize winning discovery of LDL receptors and the mechanism of receptor-mediated endocytosis.
Youreka Science was created by Florie Mar, PhD, while she was a cancer researcher at UCSF. While teaching 5th graders about the structure of a cell, Mar realized the importance of incorporating scientific findings into classroom in an easy-to-understand way. From that she started creating whiteboard drawings that explained recent papers in the scientific literature… Continue Reading