About the PATH survey
In May 2020, we reported on a number of studies that analyzed data from the PATH survey. To recap, since 2013, there has been a remarkable survey operating in the United States that has deepened our understanding of tobacco and e-cigarettes use and consequences. It is the Population Assessment of Tobacco and Health Survey (PATH) - a longitudinal, nationally representative survey of 46000 Americans. This survey generates information on tobacco and e-cigarette use behaviours, and with its longitudinal design it interviews the same individuals every year. It is planned that the survey will continue at least until 2024.
Since May, more longitudinal analyses have been published using PATH survey data. Three of these explore the relationship between smoking cessation and e-cigarette use and merit a closer look.
PATH study finds e-cigarettes no more effective at helping smokers quit (but keeps more people using nicotine).
The first of these was published by Rufeng Chen and colleagues in June 2020. They followed a subsample of 2,535 people who were smokers in 2014-15, and who had tried at least once to quit smoking by 2015-16. Their success at quitting smoking was assessed at 2016-17. They found that, among those who used e-cigarettes to help them quit, about 13% were successful. However, this success rate was not significantly different from that achieved by smokers who used other methods to quit smoking. Importantly, two-thirds of successful quitters who used e-cigarettes were still using e-cigarettes by the time of the 2016-17 PATH survey. The authors conclude:
These results suggest e-cigarettes may not be an effective cessation aid for adult smokers and, instead, may contribute to continuing nicotine dependence.
Another PATH study finds quitting is no more likely with e-cigarettes.
Many of the same authors of the paper by Rufeng Chen and colleagues also collaborated on an August 2020 paper by John Pierce and colleagues. Pierce and colleagues used similar methods to those used by Chen and colleagues, but studied a slightly different time period, from 2013 to 2016 instead of 2014 to 2017. Use of e-cigarettes, use of approved pharmacotherapy or use of no product, all resulted in a smoking cessation rate of about 10% 1-2 years later. However, over half of e-cigarette users who successfully quit smoking were still using e-cigarettes at the end of the study period.
The authors concluded:
We found no evidence to support our first hypothesis that ENDS [electronic nicotine delivery systems] would be associated with increased abstinence duration from either cigarette or any tobacco. Twelve-month cigarette abstinence was ~10% and comparable across all methods used to quit, and the finding was robust to sensitivity analyses. Over half of those who used e-cigarettes to try to quit were still using e-cigarettes at the W3 follow-up.
Similarly our results did not support our second hypothesis that daily use of ENDS would be associated with increased cigarette abstinence.
PATH study finds frequent e-cigarette use helps smokers quit.
This study suggests that consistent and frequent e-cigarette use over time is associated with cigarette smoking cessation among adults in the US.
At first blush, this conclusion seems at odds with the previous PATH studies, but closer inspection shows the results are the same.
In this study, the authors reported only on the frequency and consistency of e-cigarette use with later quitting success. They did not report on the the relationship between all e-cigarette use and smoking cessation, although that relative risk can be calculated from the data presented in the paper. As it turns out, the RR = 1.0, indicating no relationship between all e-cigarette use and 12 months or more of smoking cessation.
Still, there would be encouraging news for e-cigarettes as a possible smoking cessation method if there were a great many "consistent and frequent" users of e-cigarettes. Regrettably this is not the case. Out of 5894 study participants who were e-cigarettes users at the beginning, only 78, just 1%, were "consistent and frequent" users of e-cigarettes. For that 1% of users, quitting with e-cigarettes was more successful.
One might ask how many e-cigarette users who were trying to quit smoking successfully quit both smoking and e-cigarette use by the end of the study period in 2016? Glasser and colleagues do not provide that datum. However, Pierce and colleagues who analyzed the same PATH data sets over the same time period do provide the information. Here is the answer
None in the daily e-cigarette use group (n=56) and 45% (95% CL, 36.8-53.5%) of the no e-cigarette group (n=162) were abstinent from all tobacco [including e-cigarettes] for 12+ months at W3.
In other words, not a single e-cigarette user who was using e-cigarettes to quit was able to quit both combustible cigarette and e-cigarettes after three years.
In general, the PATH analyses show that, at the population level, e-cigarettes are not helpful in smoking cessation and even e-cigarette users who successfully quit smoking will still be addicted to nicotine in their e-cigarettes.
Would the same findings be true in Canada?
Data from Environics Canada.
Vapers Online Survey to Measure Attitudes and Behaviours
Regarding Vaping Over Time (2019 to 2020).