Vitamin D and Type 1 Diabetes Mellitus
In a retrospective, cross-sectional analysis involving 472 subjects (203 with type 1 diabetes mellitus, 116 first-degree relatives of type 1 diabetics, and 153 controls without diabetes), serum vitamin D-binding protein levels were found to be highest in the healthy controls (median: 423.5 microg/mL), intermediate in first-degree relatives of diabetics (402.9 microg/mL) and lowest among type 1 diabetics (385.3 microg/mL). Overall, vitamin D-binding protein levels were lower in male subjects (374.7 microg/mL) than females (433.4 microg/mL). The authors conclude, "These studies suggest that multiple components in the metabolic pathway of vitamin D may be altered in type 1 diabetes and, collectively, have the potential to influence disease pathogenesis."
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