The Impacts of Calcium Ions Substitution in Hydroxyapatite with Neodymium and Zinc on Biological Properties and Osteosarcoma Cells
Engineering and Technology Journal,
2022, Volume 40, Issue 12, Pages 1-9
AbstractHydroxyapatite (HA) is one of the important biomaterials in the medical field, especially in bone treatment, because of its biological properties close to human bone. A simple co-precipitation technique was used to integrate neodymium and zinc into HA by adding neodymium nitrate and zinc nitrate as a source of substituted elements during synthesis through the wet precipitation method with controlled temperature and pH. Finally, substituted HA was sintered at 800°C after completing the biomaterial preparation. The resulting Nd-Zn/HA was globe-like with nanoparticle size. The Ca+Nd+Zn/P ratio was equal to 1.63, which is relatively close to the molar ratio of bone. Also, the ability of Nd-Zn/HA to cause apoptosis in osteosarcoma cells was discovered. The anti-tumor actions are amplified when increasing the concentration of substituted HA. Therefore, Nd-Zn/HA is a potentially effective biomaterial in osteosarcoma treatment. Meanwhile, it has antibacterial and fungicidal properties against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Escherichia coli, and Candida albicans—one of the important properties required in biomaterials to protect the part that is being treated after the biomaterial is implanted inside the body. The inhibition zone of Nd-Zn/HA ranged between (20-31)mm, much higher than gentamicin and nystatin.
- The wet precipitation method can use to prepare valuable substituted hydroxyapatite.
- Substituted hydroxyapatite with rare earth elements (Neodymium) and Zinc have antibacterial and fungicide activity.
- Elements used in substitution can be led to a grateful change in the anticancer effect of Nd-Zn/hydroxyapatite.
- Substitute part of calcium ion with other ions can generate safe biomaterial on the human body.
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