Discussion 1 1. Anemia of chronic disease is a common occurrence in elderly patients. What is the pathophysiological mechanism behind this disease process? 2. Virchow's triad refers to states that can produce hypercoagulability. What are the three categories? Give an example for each and explain the pathophysiological changes seen. Discussion 2 1. Discuss the epidemiology of thalassemia and share evidence-based practice guidelines necessary for chronic management. 2. Sickle-cell anemia has treatment parameters in the chronic state and acute exacerbation. The acute phase requires aggressive hydration and pain medication. What is the physiologic pattern for this problem?