A Pilot Study- Prevention of Capecitabine Induced Hand and Foot Syndrome
Capecitabine is a common anti cancer drug. One of the most common side effects is a syndrome
called hand and foot syndrome which comprises of hands and feet redness, swelling, dryness
and painful sores. Quite often the drug dose is reduced to suboptimal level due to this side
effect. There is no way to prevent or an effective way to treat this side effect. Our aim is
to investigate whether wearing socks which contain copper fibers may prevent or alleviate
the patient symptoms.
The patients will use socks containing copper-oxide impregnated fibers which are sold in the
Pharma stores without physician's prescription.(EPA numbers 8454-2, 8454-3 from April 30
Drug Toxicity and skin reaction will be documented.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
skin feet toxicity
within the first year from starting Capecitabine use
Rinat Yerushalmi, MD
Rabin Medical Center, Affiliated to Tel-Aviv University, Tel-Aviv, Israel
Israel: Ministry of Health