Advanced Inflammation Pain Relief
Advanced pain relief with Bromelain, Turmeric and Quercetin for inflammation related to arthritis and joint pain.
Arthritis is an inflammation of the joints. If you relieve the inflammation, you relieve the pain that comes with it.
More than one-quarter of all adults experienced lower back pain within the past three months, while 15 percent had severe headaches or migraines. Fifteen percent also reported neck pain.
Chronic pain is any physical discomfort lasting for at least six months. Chronic pain affects up to 50 million Americans, most of whom work full time. Common forms of chronic pain include headaches, backaches, arthritis and trauma caused by sports injuries and car accidents.
New Zealand scientists report that Pfizer’s painkiller Celebrex is no safer than other drugs like Vioxx in the COX-2 inhibitor class that have been pulled from the market, adding to questions about the drug’s future. Unlike other COX-2 inhibitors, like Pfizer’s Bextra and Merck’s Vioxx, Celebrex remains on the market with the FDA’s strongest possible safety warning label.
Doctors have warned that the painkiller ibuprofen can raise the risk of having a heart attack. A study by British researchers suggests regular use of the drug increases the chances of an attack by almost a quarter.
Other painkillers in the same family of anti- inflammatory drugs - used by millions of arthritis patients - are even more hazardous, raising the risk by up to 55 per cent, according to the study.
Inflammation is the body's response to irritation, infection or injury. It begins at the level of the cell when, in response to an injury or irritation, white blood cells in the bloodstream begin to stick to the cells lining the blood vessel wall. The end result of this process is inflammation and pain.
Chronic systemic inflammation is an underlying cause of many seemingly unrelated, age-related diseases. As humans grow older, systemic inflammation can inflict devastating degenerative effects throughout the body (Ward 1995; McCarty 1999; Brod 2000). This fact is often overlooked by the medical establishment, yet persuasive scientific evidence exists that correcting a chronic inflammatory disorder will enable many of the infirmities of aging to be prevented or reversed.
The pathological consequences of inflammation are well documented in the medical literature (Willard et al. 1999; Hogan et al. 2001). Regrettably, the dangers of systemic inflammation continue to be ignored, even though proven ways exist to reverse this process.
NSAIDs (nonsteroidal anti-inflammatories) like aspirin and ibuprofen are effective painkillers, but they often cause stomach upset, ulcers, liver and kidney damage and gastrointestinal bleeding. Too much Tylenol can kill you! Prescription drugs that address arthritis pain (such as Vioxx and Celebrex) prevent the release of cyclooxygenase 2 (more commonly known as COX-2) a chemical in the body that causes inflammation. These COX-2 inhibitors, however, often cause severe side effects, including heart attacks and strokes. More than 260,000 hospitalizations and 26,000 deaths each year are associated with long-term use of anti-inflammatories. In fact, Merck has to withdraw Vioxx from the market for this reason.
Fortunately there are natural and effective options to NSAIDs and COX-2 inhibitors in treating arthritis pain, with a minimum of side effects. This product is especially good for trainers, physical therapists, and athletes for sports injuries and sports medicine.
Advanced Pain Relief Ingredients:
Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. It inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. In addition, it exerts potent antioxidant activity and vitamin C-sparing action.
Quercetin is a flavonoid that forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. Quercetin is found to be the most active of the flavonoids in studies, and many medicinal plants owe much of their activity to their high quercetin content.
Turmeric, the spice that is predominately used in curry powder, is used for various medicinal conditions including arthritis, wound healing, skin infections, liver and urinary tract diseases and as a blood purifier. The major constituent of turmeric is curcumin. Arthritis patients given curcumin showed a significant improvement in morning stiffness, walking time and reduction in joint swelling. An additional side benefit is anticancer properties and tumor suppression. Biological Basis for the Use of Botanicals in Osteoarthritis and Rheumatoid Arthritis: A Review, Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM. Evid Based Complement Alternat Med. 2005 Sep; 2(3): 301-308.
The medicinal properties of the turmeric have for millennia been known to the ancient Indians and its medical properties have been expounded in the Ayurvedic texts. It is only in recent years that researchers have recognised the medicinal properties of turmeric. According to a 2005 article in the Wall Street Journal titled, "Common Indian Spice Stirs Hope," research activity into curcumin, the active ingredient in turmeric, is exploding. Two hundred and fifty-six curcumin papers were published in the past year according to a research of the U.S. National Library of Medicine for its anti-cancer and anti-inflammatory properties and prevention of Alzheimer's disease.
According to Gregory Cole, Professor of medicine and neurology at the David Geffen School of Medicine at UCLA, "Curcumin has been used for thousands of years as a safe anti-inflammatory in a variety of ailments as part of Indian traditional medicine."
Bromelain is a sulfur-containing enzyme that is extracted from the stem of the pineapple and is as effective as nonsteroidal anti-inflammatory medications for reducing pain associated with osteoarthritis. Bromelain also helps reduce the pain associated with rheumatoid arthritis and is helpful as part of long-term treatment for connective tissue disorders including bursitis and tendinitis.
Bromelain can be used in a vast array of medical conditions. It was first introduced in this area in 1957, and works by blocking some proinflammatory metabolites that accelerate and worsen the inflammatory process. It is an anti-inflammatory agent, and so can assist with sports injury, trauma, arthritis, and other kinds of swelling. Its main uses are athletic injuries, digestive problems, phlebitis, sinusitis, and aiding healing after surgery.
Bromelain is also used for arthritis, chronic venous insufficiency, easy bruising, gout, hemorrhoids, menstrual pain, autoimmune disorders and ulcerative colitis. Studies have shown that bromelain can also be useful in the reduction of platelet clumping and blood clots in the bloodstream, especially in the arteries.
Ginger has been commonly used to treat inflammation. It may also have blood thinning and cholesterol lowering properties, making it effective in treating heart disease; while early studies have shown some efficacy, it is too early to determine whether further research will bear this out.
53-4 Advanced Pain Relief 90 Capsules $34.95
People with sore, overworked muscles and painful joints are praising CMO Arthritis - Muscle Pain Control Cream with Cetyl Myristoleate.
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For additional arthritis support we have several other excellent supplements:
Omega 3 Fish Oil
Glucosamine Sulfate Complex
Hyaluronic Acid with MSM
Arthritis Relief Oral Spray Formula
|Diseases Related To Chronic Inflammation |
||Inflammatory cytokines induce autoimmune reactions |
||Chronic inflammation destroys brain cells |
||Inflammatory cytokines attack erythropoietin production |
|Aortic valve stenosis ||Chronic inflammation damages heart valves |
||Inflammatory cytokines destroy joint cartilage and synovial fluid |
||Chronic inflammation causes many cancers |
|Congestive heart failure ||Chronic inflammation contributes to heart muscle wasting |
|Fibromyalgia ||Inflammatory cytokines are elevated |
||Inflammatory cytokines attack traumatized tissue |
|Heart attack ||Chronic inflammation contributes to coronary atherosclerosis |
|Kidney failure ||Inflammatory cytokines restrict circulation and damage nephrons |
||Inflammatory cytokines induce an autoimmune attack |
|Pancreatitis ||Inflammatory cytokines induce pancreatic cell injury |
||Inflammatory cytokines induce dermatitis |
||Chronic inflammation promoted thromboembolic events |
|Surgical complications ||Inflammatory cytokines prevent healing|
In addition to herbs, you can also take dietary steps to reduce inflammation. The specific fats in your diet affect the way the body makes prostaglandins, a group of hormones that regulate inflammation. Some prostaglandins intensify the inflammatory response while others reduce it. To help your body reduce inflammation eliminate polyunsaturated vegetable oils, margarine, vegetable shortening, all partially hydrogenated oils and all foods that contain trans-fatty acids (read food labels to check for the presence of these oils). Instead, use extra-virgin olive oil as your main fat and increase your intake of omega-3 fatty acids found in oily, cold-water fish, flaxseeds or oil, and walnuts.
Research References - Herbs and Inflammation:
1. Hayllyar J et al. Gastro protection and nonsteroidal anti-inflammatory drugs. Drug Safety, 7, 86,:86-105, 1992.
2. Ament P W et al. Prophylaxis and treatment of NSAID-induced gastropathy. Am Fam Phys 1997. 1997;4:1323-6.
3. Silverstein F E et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis. JAMA, 284 (10): 1247-1255, 2000.
4. Simon L S. Osteoarthritis: A Review Clinical Cornerstone. 2 (2):26-34, 1999.
5. Pizzorno, J. Total Wellness. Prima Publishing, 1996 : 169-184
6. Scherak, O., et al. High dosage vitamin E therapy in patients with activated arthrosis. Z-Rheumatol, 1990; Vol.46 (6) : 369-373
7. Heinle, k., et al. Selenium concentration in erythrocytes of patients with rheymatoid arthritis. Clinical and laboratory chemistry infection markers during administration of selenium. Med-Klin, 1997; 92 (suppl), 3 : 29-31
8. Deadhar 50 et al. Preliminary studies on anti rheumatic activity of curcumin. Ind J Med Res 1980; 71:632-34.
9. Satoskar R R et al. Evaluation of anti-inflammatory property of curcumin in patients with post-operative inflammation. Int J Clin Pharmacal Ther Toxical 1986; 24:651-54.
10. Murray M T. The Healing Power of Herbs. Prima Publishing, Rocklin CA; 1995: 327-35.
11. Arora R B et al. Anti-inflammatory studies on curcuma longa (turmeric). Ind J Med, Res 1971; 50: 1289-95.
12. Schweizer S et al. Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acids analogues. J Nat Prod 2000, Aug; 63 (8): 1058-1061.
13. Etzel R. Special extract of boswellia serrata (H15) in the treatment of rheumatoid arthritis. Phytomed 1996; 3: 91-94.
14. Bradley P R et al. British Herbal Compendium, Vol 1, Bournemouth, Dorset, UK: British Herbal Med Assoc., 1992, 224-26.
15. Mills S Y et al. Effects of a proprietary herbal medicine on the relief of chronic arthritic pain: A double-blind study. Br J Rheum 1996; 35: 874-78.
16. Chrubasik S et al. Treatment of low back pain exacerbations with willow bark extract: a randomized double – blind study. Am J Med 2000 July; 109 (1):9-14.
17. Srivastava K C et al. Ginger in rheumatism and musculoskeletal disorders. Medical Hypotheses 1992; 39:342-8.
18. Bliddal H et al. A randomized placebo – controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage. 2000, Jan; 8 (1): 9-12.
19. Klein G et al. Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Invest 19 (1): 15-23, 2000.
20. Cohen A et al. Bromelain therapy in rheumatoid arthritis. Pennsyl Med J, 67: 627-30, June 1964.
21. Seligman B. Bromelain: An anti-inflammatory agent. Angiology, 13: 508-510, 1962.
22. Ferrandiz J L et al. Anti-inflammatory activity and inhibition of arachidonicacid metabolism by flavonoids. Agents Action; 32: 283-287, 1991.
23. Tarayre J P et al. Advantages of a combination of proteolytic enzymes, flavonoids and ascorbic acid in comparison with nonsteroidal anti-inflammatory agents. Arzneium forsch, 27:1144-1149, 1977.
24. Yoshimoto T et al. Flavonoids and potent inhibitors of arachidonate 5 – lipoxygenase. Biochem Biophys Res Comm., 116: 612-18, 1983.
25. Weiss R F. Herbal Medicine. Beaconsfield : Beaconsfield Press, 1988; p.362
26. Grahame R et al. Devil’s Claw: Pharmacological and clinical studies. Ann Rheum Dis, 1 981; 40: 632.
27. Gottleib M.S. Conservative management of spinal osteoarthritis with glucosamine sulfate and chiropractic treatments. J. Manipulative Physiol Ther. 1997 July – Aug; 20 (6): 400-414. (JMPT)
28. McAlindon, T.E., et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA, 2000; 283,11: 1469-1475
Reginster, J.Y., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet, 2000; 357, 9252: 251-256
29. Murray, M. Glucosamine Sulfate: Nature’s arthritis cure. The Chiropractic Journal – March, 1998
30. Richmond, V.L. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sci, 1986; 39: 263-268
31. Sullivan, M.W., et al. The cystine content of the finger nails in arthritis. J Bone Joint Surgery, 1935; 16: 185-188
32. Lawrence, R.M. Methylsulfonylmethane (MSM): A double-blind study of its use in degenerative arthritis. Int J Anti-Aging Medicine, 1998; 1, 1: 50
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