“The paper … is a review and hypothesis paper identifying the missing link in Otto Warburg’s central theory,” Seyfried explains. “[Warburg] defined the origin of cancer very accurately back in the 1920s, ’30s, ’40s and ’50s in his work in Germany. Basically, he argued and provided data showing that all cancer cells, regardless of tissue origin, were fermenters. They fermented lactic acid from glucose as a substrate.
Here, we discuss the mechanisms of cancer and the influence of mitochondrial function, which plays a crucial role in the development and treatment of this disease. His landmark cancer theory is available as a free PDF.