Our Unit focuses on the following research topics:
- Use of the Measles virus, a live-attenuated vaccine (LAV), as a platform to develop new vaccines, specifically against DENV, CHIKV, HIV, SARScoV and H5N1. The efficacy of this strategy in humans has been highlighted in recent clinical studies such as that by Ramsauer et al., The Lancet Infectious Diseases, 2015. (Group F. Tangy and Group N. Escriou).
- Development of a high-throughput screening (HTS) assay allowing for the identification of the interaction between cellular proteins and viral proteins or RNA (Group A. Komarova).
- Understanding the mechanisms of attenuation of LAVs, with a specific focus on those against Yellow fever virus and Measles virus (Group N. Jouvenet and Group A. Komarova).