The Kerala study (the full text was sent to me by another blog reader, thanks!) begins with an explanation of angiogenesis, which “is the formation of new blood vessels from preexisting vessels. […] Physiologically, it plays an important role in wound healing and ovulation. Nevertheless, uncontrolled angiogenesis results in many pathological conditions.” Indeed!
Curcumin applied to wounds caused by radiation has strong healing properties. An interesting aside: while I was doing research for this part of the post, I came upon a 2007 study (http://tinyurl.com/2ahqmg) showing that curcumin has both radioprotective AND radiosensitizing properties. How about THAT? So curcumin will protect our healthy cells from the harmful effects of radiation while enhancing the murderous effects of radiation on cancer cells. At the exact same time! Extraordinary. That is why it might be very useful in the radiotherapy treatment of cancer, the study suggests. Well, I already knew about the radioprotective effects of curcumin, and now in fact I am not at all nervous about having my annual skeletal exam, but not the radiosensitizing effects. Curcumin never ceases to amaze me!
A 1999 study (see abstract: http://tinyurl.com/2fs5bw) showed that curcumin both when taken orally and applied topically improved wound healing in diabetic rats and mice.
The above-mentioned Kerala researchers point out that it seemed contradictory for curcumin to have wound healing properties when it is also has these anti-angiogenic properties. So they focused on the cellular microenvironment to see if it had “any effect on the angiogenic potential of curcuminoids.” Well, it does. This was a difficult, very technical study for me to read (the abstract will give you an idea…), but the following is more or less clear: curcuminoids stimulated the expression of proangiogenic factors when there was no extracellular stimulation (of an angiogenic response) by serum or proangiogenic growth factors, whereas, in the presence of those stimuli, curcuminoids appeared to be anti-angiogenic. Okay, perhaps this is not clear at all, now that I reread it! Well, basically, depending on the presence or absence of serum or certain growth factors, curcuminoids help normal cells live happily ever after, but they can also kill cancer cells by cutting off their blood supply.
This study gives us another example of the wonderful dual nature of curcumin, able to distinguish between the good and the bad guys. Yeah!