By definition, a chromosomal rearrangement is a chromosome abnormality that involves a change in the structure of the native chromosome. Individuals with chromosome rearrangements, such as balanced translocations or inversions, are at increased risk to produce chromosomally abnormal embryos. Genesis Genetics uses state-of-the-art technology to analyze embryo biopsies for chromosome abnormalities related to an individual’s specific rearrangement.
Each chromosome rearrangement case is thoroughly reviewed and analyzed by our team of genetic specialists. Patients have the option to speak with one of our genetic counselors about the specifics of their case prior to and/or following their embryo analysis.
Imagine the following strand of letters represents a chromosome that contains some of your genetic makeup: ABCDEFG. Now, what would happen if we took a small portion of this strand, say, “EFG,” and flipped it 180 degrees? The strand would now read, ABCDGFE. This occurrence is known as an inversion, which is a type of rearrangement where some of the chromosome is rotated, but is still located in the same spot.
A translocation arises when there is an exchange of material between two chromosomes. Specifically, a break occurs in two different chromosomes, and the two chromosome pieces that broke off switch positions. Translocations can be inherited or can occur spontaneously. A large majority of translocation carriers are healthy and are unaware of their carrier status until they try to have children. There are two types of common chromosomal translocations that can arise: