A recent article in Journal of Cell Biology outlines confirms some recent discoveries about tuft cell function and extends our knowledge a bit further.
Apparently, tuft cells are secretory cells that produce opioids in the gut. They are also the only epithelial cells that produce the COX (cyclooxygenase) enzymes needed to produce prostaglandins involved in inflammation and tumor formation.
Some physiologists had previously proposed a sensory role for tuft cells. Could they be involved in tasting foods in the gut and be part of the signaling mechanism that regulates exocrine and endocrine secretion that controls digestive and metabolic processes?
As we learn more about tuft cells, we are sure to discover a role for them in normal regulation of intestinal function as well as in important pathological processes.
Want to know more?
A fifth amendment to the intestine's constitution
Ben ShortJournal of Cell Biology 2011 192:706. Published March 7, 2011, doi:10.1083/jcb.1925iti2
[Brief synopsis of the discovery and its importance]
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium.
Gerbe, F., et al.
Journal of Cell Biology 2011 Mar 7;192(5):767-80. doi:10.1083/jcb.201010127.
[Original research article. Includes many illustrations, supplements, helps and cross references. FREE full text]
Here's a really nice teaching image from the Gerbe et al. article, which complements Figure 25-18 in the Anatomy & Physiology 7/E textbook: my-ap.us/hmdFub (includes downloadable PowerPoint slide)
Here are all the PowerPoints available with the Gerbe et al. article: my-ap.us/gKY7ZG
Chemosensory Perception in the Gut
Hofer, D., et al.
Physiology February 1999 vol. 14 no. 1 18-23
[Article proposing sensory function of tuft cells; FREE access to full text/PDF; nice images]