With continued transfusion, reticuloendothelial cells
can no longer safely store all the excess iron, which thus enters the circulation in amounts that exceed the binding capacity of Tf, and NTBI develops .
Labeled leukocytes accumulate in the reticuloendothelial cells
, or fixed macrophages of the bone marrow, the normal distribution of which closely parallels that of the hematopoietically active marrow, which is limited to the axial skeleton and proximal humeri and femurs in normal adults.
Rickettsia are gram-negative, obligate intracellular bacteria that are able to invade various eukaryotic host cells such as reticuloendothelial cells
and vascular endothelial cells in vertebrates, and epithelial cells in their invertebrate arthropod vectors.
TSAT reflects iron that is readily available for erythropoiesis, while serum ferritin level is correlated with storage iron found in the liver, spleen, and bone marrow reticuloendothelial cells
(National Kidney Foundation, 2000).
Theories proposed include development from embryonic mesenchymal rests in the adrenal glands, development from hematogenously seeded bone marrow emboli, and metaplasia of reticuloendothelial cells
. (4,8) The association of myelolipomas with hormonally active states and neoplastic conditions raises the possibility that the hormonal microenvironment may play a role in the development of myelolipomas.
Stiffel, "The physiopathology of the reticuloendothelial cells
of the liver and spleen," Progress in Liver Diseases, vol.
Pertoft, "Preparation of pure hepatocytes and reticuloendothelial cells
in high yield from a single rat liver by means of Percoll centrifugation and selective adherence," Journal of Leukocyte Biology, vol.