There was no significant difference between the performance of DOTA PET/CT and the optimal therapy. A good correlation between clinical and pretreatment imaging findings was observed.
This highlights the necessity of a multidisciplinary approach and the importance of the physician's awareness of the patient's personal history of endocrine diseases and comorbidities.
The most commonly used medications are thyroxine, liothyronine, propylthiouracil, and methimazole. These can be found by searching for clinical trials in the ClinicalTrials.gov database using the specific condition, medication, and site of interest.
Thyroid disease can cause a number of health problems due to an imbalance between production of thyroxine (T4) and triiodothyronine (T3). Symptoms such as lethargy, weight gain, heat intolerance, palpitations and irritability can occur. The underlying cause may be an autoimmune thyroid disease, a tumour or medications used for hyperthyroidism. Patients should be questioned about their symptoms and history of exposure to radiation.
Thyroid diseases are relatively common. Female patients have a higher prevalence of Hashimoto's thyroiditis, while male patients have more frequently Graves' disease and multinodular goitre. Male patients also had higher TG levels than female patients. Age of onset of thyroid diseases is different between genders, with females being diagnosed at an earlier age (19.4±9.4 years) compared with males (23.6±11.8 years). Gender differences in thyroid disorders are not apparent prior to puberty, but become evident after puberty.
Thyroid disease is a common disorder worldwide, which has become more prevalent in recent years because of increasing rates of obesity and type 2 diabetes, and increasing prevalence of autoimmune thyroid diseases. The differential diagnosis of nodular thyroid diseases includes Hashimoto's thyroiditis, Graves' disease, and subacute thyroiditis. The clinical presentation of thyroid disease varies widely depending on the underlying etiology. In addition, the terminology and classification of thyroid disorders vary greatly between countries. These differences make it challenging to understand and communicate the medical knowledge among clinicians and researchers across different countries.
Thyroid disorders continue to be prevalent among adolescents and young adults. As we learn more about the disorder, new treatments, drugs and procedures appear. Many are available today such as radioiodine therapy, radioactive iodine uptake assay and thyroid scanning. The challenge for researchers continues to be developing effective, safe and cost effective treatments.\n
Findings from a recent study showed that 108 scintigraphically negative patients were treated for 72 weeks, after which time only four of them demonstrated biochemical evidence of disease progression, while all of the remaining 100 patients remained clinically free of disease. Findings from a recent study suggest the efficacy of DOTA-PET/CT in detecting metastatic thyroid cancer.
The main cause of thyroid disease is not related to the presence of iodine deficiency. Compensatory hyperthyroidism can occur when there is an excessive production of thyroid hormones (thyroxine or triiodothyronine), which occurs if the pituitary gland produces more thyroid-stimulating hormone. This may happen due to genetic factors or irritable bowel syndrome. Thyrotoxicosis may also occur when the body does not produce enough thyroid hormone because the thyroid gland has been damaged by radiation or inflammation, or because it is not producing enough thyroid stimulating hormone. Low thyroid levels are usually caused by Hashimoto's thyroiditis, a chronic autoimmune disorder where the body attacks its own thyroid tissue.
Side effects were not uncommon in our study population. Most of the side effects we reported were mild to moderate and self-limited. There were no cases of life-threatening side effects. The risk of serious side effects was low. While our data suggest that 68-Ga-DOTA PET/CT may be associated with an increased risk of mild to moderate adverse events, all cases of serious adverse events reported were also mild or moderate. Therefore, we recommend caution when considering this diagnostic modality in cases of suspected malignancy.