Several of the pioneers who migrated across the midwest to claim a part of Symmes' tract are buried in North College Hill's oldest landmark, the LaBoyteaux-Cary cemetery. Established in approximately 1806, the cemetery includes the graves of two Revolutionary War veterans and several members of the Cary family. The last burial in the cemetery was in 1860.
In 1813-14, William Cary, having migrated from New Hampshire to Cincinnati in 1802, purchased north of Cincinnati along what is now Hamilton Avenue (U.S. Route 127). Cary built a log cabin and moved his family to this “wilderness,” then known as Mill Creek Township.
Soon after, William Cary purchased an additional 75 acres north of North Bend Road adjacent to his original tract, and sold part of it to his nephew Robert Cary. Robert called the land Clovernook Farm and initially erected a small frame house for his family. In 1832, he built the white, brick house now known as Cary Cottage (see photo) which stands on the campus of the Clovernook Center for the Blind and Visually Impaired and is listed on the National Register of Historic Places. Within a year of his settlement, Robert also laid out the first community in the area, called Clovernook, on the east side of Hamilton Avenue.
Robert Cary and his wife Elizabeth raised nine children, two of whom, Alice and Phoebe, became well-known poetesses and writers. Both girls began having their poems published as teenagers, and they eventually counted among their admirers Massachusetts poet and abolitionist John Greenleaf Whittier, New York Tribune newspaper editor Horace Greeley, and author Edgar Allan Poe, who pronounced Alice Cary's Pictures of Memory, "one of the most musically perfect lyrics in the English language.
Cary Cottage became the first home for blind women in Ohio through the work of the Trader sisters, Florence and Georgia (who was blind). In 1903 the Cary house and the land surrounding it were purchased by William Procter, grandson of the Procter & Gamble co-founder, in order to give them in trust to the Traders. The sisters used the land to establish the Clovernook home and provide employment to visually impaired women as a source of dignity and direction. Today, the Clovernook Center for the Blind and Visually Impaired offers instruction, employment, community living and low vision services for men and women, and runs three manufacturing departments, including one of the world's largest volume producers of Braille publications.
In the latter part of the nineteenth century, North College Hill was the home of Dr. Isaac Mayer Wise, who has been called “the most prominent Jew of his time in the United States” for his influence as one of the early leaders of Reform Judaism in America. In 1861 Wise and his wife Therese bought a 40 acre farm near the current intersection of Goodman and Hamilton Avenues where they raised a family of ten children. Following Wise's death in 1900, the farm was the home of his daughter and granddaughter, respectively, until 1968.
In 1925 North College Hill Mayor A. R. Pugh was involved in a Prohibition case that rose to national significance when it was appealed all the way to the Supreme Court of the United States. The court's decision in this case continues to provide precedent today in many cases involving judicial impartiality.
Through the nineteenth century, as College Hill to the south and Mount Healthy to the north matured into towns, the area that was to become North College Hill remained largely farmland. Beginning in 1905, saw mill owner John Meyer used his surplus lumber to build a subdivision of small homes north of Galbraith Road and west of Hamilton Avenue and called it Meyerville. Within the next ten years, two other groups of homes – Clovernook, east of Hamilton Avenue, and Sunshine, south of Galbraith and west of Hamilton – were started. The three subdivisions, with a total of about 500 residents, were incorporated as the Village of North College Hill in 1916.
As the automobile stretched commuting distances, the village's affordable housing attracted a growing population, and it increased from about 1,100 to 4,100 residents during the 1920s. In 1941, the village incorporated as a City and continued to grow until the population stabilized at its peak of around 12,000 by 1960. A few homes were removed for the completion of Ronald Reagan Cross County Highway (Ohio State Route 126) in 1997 and as of the 2000 census, the city's population was 10,082.
In 2007, Money magazine listed the city sixth among places "where homes are affordable.
On November 6, 2007 a ballot initiative to make North College Hill a charter city was passed by the voters.
According to the United States Census Bureau, the city has a total area of 1.8 square miles (4.8 km²), all of it land.
As of the census of 2000, there were 10,082 people, 4,191 households, and 2,535 families residing in the city. The population density was 5,491.0 people per square mile (2,115.6/km²). There were 4,488 housing units at an average density of 2,444.3/sq mi (941.8/km²). The racial makeup of the city was 76.20% White, 21.69% African American, 0.23% Native American, 0.26% Asian, 0.01% Pacific Islander, 0.47% from other races, and 1.15% from two or more races. Hispanic or Latino of any race were 0.59% of the population.
There were 4,191 households out of which 30.2% had children under the age of 18 living with them, 42.2% were married couples living together, 14.9% had a female householder with no husband present, and 39.5% were non-families. 34.4% of all households were made up of individuals and 14.4% had someone living alone who was 65 years of age or older. The average household size was 2.33 and the average family size was 3.03.
In the city the population was spread out with 25.5% under the age of 18, 7.5% from 18 to 24, 31.5% from 25 to 44, 17.5% from 45 to 64, and 18.0% who were 65 years of age or older. The median age was 36 years. For every 100 females there were 85.3 males. For every 100 females age 18 and over, there were 78.9 males.
The median income for a household in the city was $37,776, and the median income for a family was $45,149. Males had a median income of $31,964 versus $27,710 for females. The per capita income for the city was $18,915. About 6.8% of families and 8.7% of the population were below the poverty line, including 11.5% of those under age 18 and 10.3% of those age 65 or over.