Y sex-determining region: A region on the Y chromosome that determines the sex of the individual. This region goes by the symbol SRY (sex region Y). SRY is necessary and sufficient for male sex determination. It is the testis-determining factor.
Mutations in SRY give rise to XY females with gonadal dysgenesis who appear to be normal females at birth, but at puberty do not develop secondary sexual characteristics (breasts, etc.), do not menstruate, and have streak (fibrous) gonads without eggs. There is a high incidence of neoplasia (gonadoblastoma and germinoma) in the streak gonads.
Translocation (transfer) of the part of the Y chromosome containing SRY to the X chromosome results in XX males -- individuals who have XX sex chromosomes but appear male.
SRY resides in chromosome band Yp11.3 and encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA binding proteins.
Y sex-determining region: A region on the Y chromosome that determines the sex of the individual. This region goes by the symbol SRY (sex region Y).
NM_003140.1: Homo sapiens sex determining region Y (SRY), mRNA: P: BC074923.2: Homo sapiens sex determining region Y, mRNA (cDNA clone MGC:103878 IMAGE:30915260), complete cds
The official name of this gene is â€œsex determining region Y.â€ SRY is the gene's official symbol. The SRY gene is also known by other names, listed below.
What is the normal function of the SRY gene? The SRY gene provides instructions for making a transcription factor called the sex-determining region Y protein.
SRY (which stands for sex-determining region Y gene) is found on the Y chromosome. In the cell, it binds to other DNA and in doing so distorts it dramatically out of shape.