My mother in law was recently diagnosed with breast cancer and just texted us tonight and told us she is CHEK2 positive. She told us that my husband has a 50% chance of having it, and if he does our children have a 50% chance of also having it. We’ve been stress googling tonight and learning a little about it, and are also going to consult a genetic counselor and get my husband tested as soon as possible. But, we are of course panicking with little information now, and not a great understanding on what this really means. From what I read, it sounds like if he and/or our kids have it, they’re at a largely increased risk of developing multiple types of cancer. We aren’t close with his mother, and I doubt she will give us any further information on her diagnosis other than being positive for it. Could anyone explain what this means and how much of a risk he and my children really have for cancer? Does this mean, if positive, he will definitely get cancer in the future? To add to this, we were planning on starting trying for our final child in the new year. Is the severity of this high enough we should hold off?