No doubt this incompatibility, which belonged logically within the anatonioclinical experience, had been formulated quietly, or at least suspected by Prost when he had shown that the fevers differed from one another according to 'the organ in which the affection occurred', or according to 'the mode of alteration' of' the tissues,' and by Rccamier and his pupils when they had studied those diseases that were to he so crucial to the future of medicine, the meningitis group, indicating that 'fevers of this order are rarely essential diseases; they may even always be dependent on an affection of the brain such as phlegmasia, or a serous gathering'.'''