Stocks Close One Percent Lower  NEW YORK (Reuters) - The major stock indexes ended 1  percent lower on Thursday after crude oil rose to a record \$53  a barrel and drug makers like Pfizer Inc. &lt;A HREF="http://www.investor.reuters.com/FullQuote.aspx?ticker=PFE.N target=/stocks/quickinfo/fullquote"&gt;PFE.N&lt;/A&gt; and Merck    Co. &lt;A HREF="http://www.investor.reuters.com/FullQuote.aspx?ticker=MRK.N target=/stocks/quickinfo/fullquote"&gt;MRK.N&lt;/A&gt; sank on worry that the government may intensify  scrutiny of that sector.