Could the controversial drug ivermectin save lives?
The antiparasitic drug ivermectin holds promise as a COVID-19 treatment, according to a new study published in the  . The study authors conclude that ivermectin could reduce the risk of COVID-19-related death with moderate-certainty evidence. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease, they conclude, adding that the drug is likely to have a significant impact on the SARS-CoV-2 pandemic globally.  The meta-analysis analyzed databases up to April 2021, drawing from 24 randomized controlled trials with 3,406 patients. Another study published in Lancet found a concentration-dependent antiviral activity of oral high-dose ivermectin in a trial involving 45 patients. Many experts, however, have voiced skepticism regarding the use of ivermectin as a COVID-19 treatment. In May, Health Feedback concluded that ivermectin did not slow the infection rate in countries with high COVID-19 caseloads. A randomized study published in JAMA concluded that ivermectin did not appear to be an efficacious COVID-19 treatment for mild COVID-19, but critics pointed to methodological flaws in that study. FDA has warned consumers of using the drug to treat or prevent COVID-19, as the agency has not authorized the use of the drug as a treatment for the novel coronavirus, and large doses of the drug can cause serious side effects. WHO and NIH have come to similar conclusions regarding the use of ivermectin as a COVID-19 treatment. In March, WHO concluded that ivermectin should only be used as a COVID-19 treatment in clinical trials. In February, ivermectin manufacturer Merck concluded there was no solid scientific basis for using ivermectin as a COVID-19 treatment.