Are we going to need COVID-19 booster shots?
Just because Pfizer wants to offer COVID-19 vaccine boosters doesnt mean people will be lining up anytime soon  U.S. and international health authorities say that for now, the fully vaccinated seem well protected. Globally, experts are watching closely to determine if and when people might need another shot. At the same time, many suggest the priority for the time being should be vaccinations, noting that worrisome coronavirus mutants wouldnt be popping up so fast if more of the U.S. and the rest of the world had gotten the initial round of shots. "If you want to stop hearing about the variant of the week," said Jennifer Nuzzo, a Johns Hopkins University public health specialist, "we need to do more work to make sure all countries have more access to vaccines." Here are some questions and answers about vaccine immunity and boosters. U.S. health officials have long said that people one day might need a booster  after all, they do for many other vaccines. That's why studies are underway to test different approaches: simple third doses, mix-and-match tests using a different brand for a third dose, or experimental boosters tweaked to better match different variants. But last week, Pfizer and its German partner BioNTech announced that in August, they plan to seek Food and Drug Administration authorization of a third dose because it could boost levels of virus-fighting antibodies, possibly helping ward off worrisome mutants. Sign up for coronavirus updates Get the latest news on Long Island's reopening from COVID-19 restrictions, updated safety guidelines and vaccination rates. By clicking Sign up, you agree to our privacy policy. The companies haven't publicly released data, and U.S. health officials issued a sharp response that boosters aren't yet needed and that the government, not vaccine makers, will decide if and when that changes. The World Health Organization said Monday there is not enough evidence to show that third doses are needed. It said the scarce shots should be shared with poor countries instead of being used by rich countries as boosters. An Associated Press analysis last month found nearly all COVID-19 deaths in the U.S. are occurring among the unvaccinated. In the last few weeks, infections and hospitalizations have begun rising as the highly contagious delta variant spreads. But the Centers for Disease Control and Prevention says the surges are driven by the least vaccinated parts of a country that has plenty of shots if people would only take them. No vaccine is perfect, meaning fully vaccinated people occasionally will get infected, but those so-called breakthrough cases usually are mild. Officials monitoring the need for boosters are watching closely for any jumps in serious breakthrough infections. So far the news is good: The people first in line for vaccines back in December and January dont seem to be at higher risk for breakthrough infections than those vaccinated more recently, the CDCs Dr. Jay Butler said Tuesday. No, scientists also are watching to see how much vaccinated people's overall immunity to the coronavirus wanes. That, too, could require a booster shot. Virus-fighting antibodies do gradually wane. That's normal since the body doesnt need to be on high alert forever. But antibodies arent its only defense. By the time those levels drop, the body has formed backups. They include memory B cells that, the next time youre exposed, "explode, and they start dividing like mad" to make new antibodies, said University of Pennsylvania immunologist Scott Hensley. Another backup: T cells that kill virus-infected cells to help keep a breakthrough case from becoming severe. Lab studies signal antibodies arent as potent against the delta variant as they are against some earlier versions of the coronavirus but are still protective. Specialists worry more about the prospect of future mutants that might escape todays vaccines, something preventable only by cracking down on viral spread everywhere. Real-world data from England, Scotland, Canada and Israel shows that the vaccines most widely used in Western countries continue to provide strong protection. Researchers in Britain found two doses of the Pfizer vaccine, for example, are 96% protective against hospitalization with the delta variant and 88% effective against symptomatic infection. Israel recently reported preliminary data suggesting protection against mild delta infection has dipped lower, to 64%. But protection against severe illness remained high. Theres less information about how well other vaccines hold up against the delta variant. Thailand announced this week that health workers who had received two doses of a Chinese vaccine would be given a booster shot made by AstraZeneca. Thats possible. Israel just began dispensing third doses of the Pfizer vaccine to transplant recipients and other patients with weak immune systems. The reason: People who take certain immune-suppressing medications dont react as strongly to any vaccinations  not just COVID-19 vaccines  as healthy people. France already had a similar third-dose policy for the immunocompromised. And even though its not authorized in the U.S., some transplant recipients seek out a third dose in hopes of more protection. Its not yet proven if a third dose helps and, if so, who needs one and when. The first large study of the strategy is beginning in thousands of patients in Norway.