A man died after he was struck by a car on the N2 at Balrath in County Meath at 01:30 local time on Sunday.
Elsewhere, a man in his 30s died after the car he was driving hit a fence at Knockanour, Castlebar, County Mayo.
The incident happened shortly before 19:30 local time on Saturday.

Dieumerci Mbokani is doubtful due to illness, but Abel Hernandez could return after a hamstring injury.
Burnley winger Johann Berg Gudmundsson is out after tweaking a medial knee ligament against Lincoln.
Fellow midfielder Steven Defour is back in training after a hamstring injury but won't feature on Saturday, while Jeff Hendrick is still suspended.
Steve Bower: "At the turn of the year Hull looked doomed; devoid of any confidence and hope. The impact Marco Silva and his new faces have had since has been remarkable.
"The atmosphere has changed and, so too, have their chances of survival. They have used the break to continue to bond at a week-long training camp in Portugal.
"Now the Tigers have an opportunity to record three consecutive home wins in the Premier League for the first time.
"They face a Burnley team who, incredibly, only have a solitary point on their travels.
"That has to change at some stage and Sean Dyche's team will hope for a response after last weekend's cup shock.
"A trip to Hull, though, is a different proposition to earlier in the season."
Twitter: @SteveBowercomm
Hull head coach Marco Silva: "The pressure always stays with the team and the coaches.
"It's one more game and of course we respect Burnley. We want to win and prove ourselves on the pitch."
Burnley manager Sean Dyche on his side's run of four away games in a row:  "I think it's brilliant for us because the timing's magnificent.
"The teams on the opposite side, they are expected (to win) now, we're not because everyone looks at the form book and goes, 'Well it's going to be hard for them to win away because they haven't won any away'.
"Expectancy grows on the team you're playing now. Statistics work in your favour over a season and mindset works in your favour because the pressure is on the opposition."
I think most Burnley fans would rather see their side win this game than have beaten Lincoln in the FA Cup.
Having said that, I don't see Sean Dyche's side beating Hull. The Tigers are scrapping for anything they can get at the moment.
Prediction: 1-1
Lawro's full predictions v Let it Shine judge Martin Kemp
Head-to-head
Hull City
Burnley
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.

The Save Our Falmouth Group organised the event in response to the latest planning applications for large scale student accommodation.
Protestors say the demand on housing is already high and any more students will have a detrimental effect on the town.
A Falmouth University spokesperson said there are two public consultation events taking place this month.

The discovery of the body in Northampton is being linked to the disappearance of Adeyemi Olugbuyi, 32, known as "Big Man", in September 2013.
Nigerian Mr Olugbuyi, who was last seen in North Holme Court, Thorplands, had been involved in an "altercation" in the area.
Police said officers were treating the death as murder.
Known as "Baz" or "Big Man", he is believed to have been involved in an altercation in the area just after 08:00 BST on 13 September.
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Since that time, he has not been in any contact with family or friends.
A police spokesman said: "Investigators believe the body is likely to have been there for some considerable amount of time, possibly months or years."
Police said formal identification had yet to take place.
Officers have been searching green areas around Billing Brook Road, where the body was found, and were using a dog unit at the scene.
Two men have died in separate crashes in the Republic of Ireland.
[NEXT_CONCEPT]
Hull will be without midfielder Sam Clucas this weekend because he is serving a one-match suspension.
[NEXT_CONCEPT]
A demonstration has been held over the rise in the number of students at Falmouth University in Cornwall.
[NEXT_CONCEPT]
The body of a man found in a hedge by litter pickers might have lain undetected for years, police have said.