# Mikey Madison's Oscar win over Demi Moore compared to 'The Substance'

Did life imitate art at the 2025 Academy Awards?

Fans of Demi Moore's performance in "The Substance" have suggested as much. In a tight race, Moore lost the best actress Oscar to "Anora" star Mikey Madison, and social media was quick to compare the outcome to "The Substance" itself.

In the body horror film, Moore stars as an aging film actress and television host, Elisabeth Sparkle, who is fired after turning 50 because the network wants to replace her with a younger star. She begins taking an experimental drug that creates a younger version of herself, Sue, played by Margaret Qualley. Elisabeth soon grows jealous of her alter ego while Sue is rapidly embraced by the public.

Fans couldn't help but see the irony after Moore lost the best actress Oscar to a younger star, Mikey Madison, and social media was quick to compare the outcome to "The Substance" itself.

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