# Hantavirus pulmonary syndrome: the infection that killed Betsy Arakawa, Gene Hackman’s wife

Virus that caused death of actor’s wife in Santa Fe is rare but serious illness that can damage major organs of the body

Authorities said on Friday that actor  days after his wife, Betsy Arakawa, died from hantavirus pulmonary syndrome (HPS). But what exactly is this rare illness?

Hantavirus pulmonary syndrome is a rare but serious viral disease that can damage the heart, lungs and other organs. The syndrome progresses quickly and can be fatal, according to the , one of the largest and most respected medical centers in the US.



Betsy Arakawa and Gene Hackman at the Golden Globes in 2003. The pair died in New Mexico last week.



## Hantavirus pulmonary syndrome: the infection that killed Betsy Arakawa, Gene Hackman’s wife

Hantaviruses cause two syndromes, including HPS and hemorrhagic fever with renal syndrome, according to the . People can contract HPS by inhaling, eating, drinking or coming into contact with infected mouse or rat feces, urine or saliva. Although not all mice and rats carry hantaviruses, some species, including deer mice, white-footed mice, rice rats and cotton rats, are known carriers in North America.

“Between one and eight weeks after that exposure, someone might begin to feel like they have a flu-like illness,” Dr Sonja Bartolome of the UT Southwestern Medical Center in Dallas told the Guardian.

In the United States, most cases of HPS occur in states west of the Mississippi River.

“It’s mostly in rural areas, because that’s where most of the rodents carrying the disease live,” Bartolome said.

HPS remains rare in the US despite its severe symptoms. Between 1993 and 2022, there were 864 reported US cases.  had the highest number during that time, at 122, followed by Colorado, at 119.

Person-to-person transmission is extremely rare and has only been documented in cases of a hantavirus strain found in Argentina and Chile.

Once the hantavirus enters the body, it replicates and spreads, which can cause a severe amount of damage in the lungs. The virus weakens blood vessels and causes leakage and fluid buildup in the air sacs, making breathing difficult.

In the heart, it damages the heart muscle and weakens blood vessels while reducing the heart’s ability to pump oxygen-rich blood to the body’s organs. If untreated, these effects can lead to shock, organ failure and death.

HPS symptoms work in three phases. The first is the incubation phase, lasting up to eight weeks, during which time the virus is present in the body but no noticeable symptoms are present.

The second phase develops quickly and includes fever, chills, fatigue, muscle aches, stomach pain, nausea, vomiting, diarrhea, rash, dry cough, headache and dizziness. This stage lasts between two and eight days.

About four to 10 days after these initial symptoms, the third and most severe phase begins. This last phase includes internal bleeding, fluid-filled lungs, difficulty breathing, a rapid heartbeat and chest tightness. These symptoms can be life-threatening and require immediate medical attention.

There is no specific treatment or cure, but early medical attention can increase the chance of survival. Patients usually require oxygen therapy, fluid replacement, medications to stabilize blood pressure and antiviral medications such as ribavirin, among other care. If patients survive the late-stage symptoms, recovery typically takes a few weeks.

Although no vaccine exists for HPS, the Cleveland Clinic recommends taking prevention strategies to help reduce risk. These include avoiding wild rodents, sealing entry points in homes, properly cleaning and disinfecting rodent-contaminated areas, using protective gear when handling droppings and keeping food securely stored.

Sweeping or vacuuming droppings is not recommended because it could release virus particles into the air.

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