State of California—Health and Human Services Agency
California Department of Public Health

Erica Pan, MD, MPH, FIDSA, FAAP
Director and State Public Health Officer

 GAVIN NEWSOM
Governor

March 3, 2025

To: All Interested Parties

Subject: Request for Applications (RFA) for Human Immunodeficiency Virus (HIV) Pre-
Exposure Prophylaxis (PrEP) and Post-Exposure Prophylaxis (PEP) Navigator Projects,
2025-2028

Funding for this RFA is established in the California Health and Safety Code Section
120972.1. Upon appropriation in the annual Budget Act, California Department of Public
Health, Office of AIDS (CDPH/OA) shall award grants in the amount of $1.76 million
annually over three years, on a competitive basis, to community-based organizations
(CBOs) and/or local health jurisdictions (LHJs) to establish, integrate, and strengthen
PrEP and PEP navigation services within the funded agency and make low-barrier
PrEP and PEP available to specified priority populations.

Applicants must either demonstrate capacity or propose innovative approaches to
engage priority population(s) and navigate them to PrEP and PEP. For the purposes of
this funding, OA defines “innovative” as the application of new ideas and/or promising
practices to address the needs of the priority population(s). By the end of the project
duration, the funded agencies should have effectively integrated and/or improved low-
barrier access to PrEP and PEP into their existing structures by providing navigation
services and benefits enrollment.

Based on 2022 data from the California HIV Surveillance Report and the HIV/AIDS
Epidemiology and Health Disparities Report, the primary priority population(s) for this
RFA are: 1) men who have sex with men (MSM), transmen who have sex with men,
and/or non-binary people who have sex with men who identify as Black/African
Americans (AA), Latinx, Native Hawaiian/other Pacific Islanders, and American
Indian/Alaska Natives; 2) transgender women; 3) Black/AA and Latinx cisgender
women; 4) people who test positive for syphilis; and 5) MSM with rectal gonorrhea or
rectal chlamydia infections.

The HIV PrEP and PEP Navigator Projects RFA can be accessed at:
www.cdph.ca.gov/Programs/CID/DOA/Pages/RFA-25-10048.aspx

Please note the following important dates:

CDPH Office of AIDS, MS 7700 l P.O. Box 997426 l Sacramento, CA 95899-7426
(916) 449-5900 ● (916) 449-5909
Internet Address: www.cdph.ca.gov

• HIV PrEP and PEP Navigator Projects Pre-Application Webinar will be held on

March 11, 2025 from 1:00 PM to 2:00 PM, Pacific Time.
Zoom link:
us06web.zoom.us/j/81057824485?pwd=isTtJH4prqh6r5pHR50eQX9k8
DuJ0X.1
Meeting ID: 810 5782 4485
Passcode: 886240

• Questions about the HIV PrEP and PEP Navigator Projects RFA must be
submitted in writing by email to PrEPNavRFA@cdph.ca.gov by March 14,
2025 by 5:00 PM, Pacific Time.

• Questions and responses will be posted on the RFA landing page by March

•

21, 2025 by 5:00 PM, Pacific Time.
Mandatory electronic Letter of Intent (LOI) is due on March 26, 2025 by 5:00
PM, Pacific Time. RFA Attachments will be sent to those who submit LOI.
• Electronic applications must be submitted by April 14, 2025 by 5:00 PM,

Pacific Time. Late applications will not be accepted.

• Please see the RFA for LOI and application submission information.

OA looks forward to receiving applications to support, establish, or expand PrEP and
PEP navigator services programs to improve health outcomes, reduce HIV-related
health disparities, reduce new HIV infections, and achieve maximal results in
addressing the HIV epidemic in California. If you have any questions about the
information in this letter, please send an e-mail to PrEPNavRFA@cdph.ca.gov.

Sincerely,

Marisa Ramos, PhD
Office of AIDS Division Chief
Center for Infectious Diseases

HIV PrEP and PEP Navigator Projects RFA Announcement

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