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Today I talk about my REJUVENATE!™ BERRIES & HERBS high-RNA superfood. I designed it to be a super-delicious, intensely berry flavored superfood with no greens. I put in real organic berries—BLUEBERRY, STRAWBERRY, RASPBERRY, and CRANBERRY—so it bursts with true berry flavors! I recently updated the formula, so it is is more delicious and nutritious than ever.
REJUVENATE! BERRIES & HERBS – A COMPLETE SUPERFOOD
Rejuvenate! Berries & Herbs is a delicious high-RNA (390 mg), high-protein (14.6 g) (organic pea and organic rice), high-antioxidant (ORAC value of 14,000+), high fiber (13 g) superfood with a creamy smoothness and rich berry flavor that tastes beyond great! It also boosts health with a complete multivitamin-multimineral sub-formula and important cell-protective herbs (herbal complex) that includes ginger, dandelion, burdock, turmeric, green tea extract, astragalus, and many other health-building herbs.
How to use Rejuvenate! Berries & Herbs? Just mix in water, juices, nut milks, or smoothies to create a drink with superb health benefits. Or use it creatively in foods, such as nut butters, salads, fruits, sauce/dressings, or desserts. It tastes so good, some people like to eat it by itself—or mixed in a little purified water.
HEALTHY AND HIGH-RNA BY DESIGN
Rejuvenate! Berries & Herbs is among HPDI’s premier high-RNA superfoods. That is, Rejuvenate! Berries & Herbs is one of three Rejuvenate! superfoods, which are the world’s first—and only—dedicated high-RNA superfoods. High-RNA nutrition means high in dietary nucleic acids, which Dr. Benjamin S. Frank considers to be essential nutrients, like vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy). Dr. Frank’s studies demonstrate many benefits of nucleic acids, including: greater energy, endurance, functional strength, easier breathing (anti-anoxic effect), as well as cardiovascular benefits and cosmetic benefits (smoother skin and a more youthful appearance).
• Delicious Berry Flavor Bursts with Real Organic Berries! • Powerful Organic and Wildcrafted Cell-Protective Herbs • High ORAC Value (~14,270 units)
• 390 mg Dietary Nucleic Acids (RNA/DNA) from Vegetarian Sources • Multiple Prebiotics Supporting your Microbiome • Gluten Free, Vegan/Vegetarian, No Artificial Ingredients • Mixes Well with other Rejuvenate!™ Superfoods
My updated formula (as of 12/2018) features, per serving:
– 2.6 g more protein (14.6 g total) – Very little sugar (1.2 g total) – 7.0 g more fiber (13 g total) – 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan – 700 mcg of folate as 5-MTHF (natural, coenzyme folate) – A smooth & delicious taste (even better than before!)
Given all the upgrades I recently made to the formula, I certainly hope you will give it a try. I’m so happy with it, and I use it daily. Berries & Herbs hardly feels (or tastes!) like a nutritional supplement. But believe me, there are few superfoods anywhere that provide as much nutrition—or nutrient density!
HIGHEST QUALITY INGREDIENTS – INCLUDING ORGANIC AND WILDCRAFTED
To give you a better idea of the high-quality ingredients I put into Rejuvenate! Berries & Herbs, check out this complete list of ingredients:
Today I make a tasty smoothie with the new, improved REJUVENATE!™ BERRIES & HERBS superfood. In fact, Rejuvenate! Berries & Herbs is likely the most delicious among HPDI’s Rejuvenate! superfoods, as it contains for types of real organic berries: Blueberries, Strawberries, Raspberries, and Cranberries. This uber-berry superfood was born for smoothies.
Rejuvenate! Berries & Herbs is a uniquely healthy superfood that not only tastes amazingly good, but its high berry content gives it an ultra-high antioxidant value (ORAC) of 14,270 units per serving—an exceedingly high ORAC value compared to typical “superfood” formulas.
Rejuvenate! Berries & Herbs provides 14.6 gm of organic protein (including organic pea and organic rice). It includes a potent cell-protective herbal complex (including green tea extract, ginger, turmeric, astragalus, burdock, dandelion, and rhodiola). In addition, it contains a built-in multivitamin sub-formula including coenzyme vitamins and other highly assimilable forms of important micronutrients.
I especially love Rejuvenate! Berries & Herbs because my father Dr. Hank Liers formulated it to provide the most dietary nucleic acids per serving—390 mg (dietary RNA/DNA)—the most per serving in any Rejuvenate! superfood. Sources of dietary nucleic acids in Rejuvenate! Berries & Herbs include nutritional yeast, yeast extracts, and CGF (chlorella growth factor).
Dietary nucleic acids are proven to provide significant benefits for health. Studies by pioneering nucleic acid researcher Benjamin S. Frank, MD, PhD indicate effects such as greater endurance, easier breathing (anti-anoxic effect), increased energy (ATP production), improved functional strength, warmer body temperature (e.g., cold resistance), and other effects. Dr. Frank asserts that dietary nucleic acids are essential nutrients, not unlike vitamins and minerals (Dietary Nucleic Acid Nutrition & Therapy).
Considering all the benefits conferred by dietary nucleic acids, you really cannot go wrong by consuming more of them daily. And Rejuvenate! Berries & Herbs helps you do that by providing nearly 400 mg of dietary RNA/DNA per serving. That is a therapeutic dose which means you stand to gain all the benefits they confer. Depending on who you are and your health status, that could mean a lot in terms of helping you be healthier.
In sum, Rejuvenate! Berries & Herbs uniquely offers: 1) High RNA (dietary nucleic acids), 2) High Antioxidant Levels, 3) Herbal Sub-Formula, 4) High Protein, 5) Built-in Multivitamin, and 6) SUPER TASTE—that is super delicious in your superfood smoothies.
You just cannot get all these benefits in ANY other superfood, including other Rejuvenate! superfoods, each of which is formulated with a specific purpose. For example, Rejuvenate! PLUS is designed to provide significant levels of greens (think chlorella and spirulina), but lacks berries. Within its berry bailiwick, Rejuvenate! Berries & Herbs truly stands alone as one-of-a-kind.
REJUVENATE! BERRIES & HERBS highlights:
• Delicious Berry Flavor Bursts with Real Organic Berries (blueberries, strawberries, raspberries, cranberries)! • Powerful Organic and Wildcrafted Cell-Protective Herbs • High Antioxidant (ORAC) Value of 14,270 units per serving! • Contains Multiple Prebiotics Supporting Your Microbiome • Suitable for Vegetarians and Vegans & Gluten Free • Mixes Well with other Rejuvenate!™ superfoods (like Rejuvenate! PLUS and Rejuvenate! Original Greens) and smoothie ingredients.
New, improved REJUVENATE! Berries & Herbs features (per serving): • 14.6 g protein • Very little sugar (1.2 g total) • 7.0 g more fiber (13 g total) • 100 mg of organic BiAloe® aloe vera gel powder with over 18% acemannan • 700 mcg of folate as 5-MTHF • Smooth texture & delicious taste!
There you have it. If you’re anything like me—and you love the taste of real, organic berries—consider Rejuvenate! Berries & Herbs to be your greatest ally when it comes it to tasty and healthy superfood nutrition. Make yourself a Berries & Herbs smoothie, and start creating health naturally today! ~
HPDI’s sponsored athlete Irena Ossola has been a bike tour leader in Italy this summer and fall. During that time, she scaled back her nutritional supplement regimen. This is partly because the summer and fall period is one of rest from high-intensity competitive bike training—and because her training for the new racing season has not yet begun. However, she recorded her observations regarding nutritional supplements. She concludes they are important whether or not she is actively training for races. – editor
I have been working like a maniac and nonstop since I arrived in Italy for my bike touring job at the end of August. However, I am feeling good and recovering well and happy to move forward for next year in training. I am starting to really look forward to getting in some hard solid winter training now and especially being in Tucson will be amazing!! I can’t wait to get back into my regular training regime. On another note, I’ve recorded some observations during my time in Italy about my nutrition and vitamins.
“As I am now at the beginning of my touring/working season, I like to use this time as my sort of “off time” for supplements. Regarding vitamins and other nutritional supplements, I have found in the past that I have trouble staying on schedule and taking them while working. I feel that my nutrition is still adequate as I eat vegetables and meat and other necessary things for the amount of effort and activity I am putting my body through. Yet, I also know I will feel the difference without a constant flow of vitamins and supplements from Health Products Distributors, Inc.”
“Now that I am in my moment of break and I’ve been working constantly for about a month, I must stay that I have also not been taking vitamins for a couple weeks and I can definitely feel the difference. Especially in my diet when I am not eating as healthy (as I do when training) or being as consistent with consuming vegetables.
I notice a lack of energy when I am working and lack of intensity on the bike when I’m riding. This is fine for now, and a good test for me as during this time I do not need a high-intensity effort while riding and it is a good test of my energy levels to see the contrast while I’m working compared to training.
I will begin taking some supplements again regularly which I think will help and will also demonstrate the necessity to have a regular schedule of nutritional supplements even when my work and travel schedule is so busy.”
“Boy do I feel the difference! Since I have been regularly taking supplements again I can feel my energy going up and my willingness to push more and have more intensity on the bike. I feel the difference in my regular diet as well as I feel more motivated to eat healthy. This is a big contrast and difference I can see from the period when I was taking supplements to when I stopped and now again to taking them. This shows how big the influence of nutritional supplementation is for my body.
I will continue taking my vitamins and being active while working and also eating a healthy diet to maintain my energy levels and physical ability. I am so busy while working that supplements are often hard to take while changing hotels or setting things up for the day. But if I have my vitamin bag and make sure to keep it somewhere easily accessible, then I am more willing to take them and can easily.
Almost daily articles, reports, or studies appear claiming nutritional supplements are not effective. The claims vary, but the verdict is always there is little or no scientific evidence proving supplements (or the nutrients in supplements) work. Others assert that people who take supplements have the world’s most expensive urine. This is nonsense! The scientific evidence is clear, available, and it has been for a long time.
Among the many problems with these reports is bashing supplements based on studies using low dose or non-therapeutic levels of nutrients. There is frequently failure to consider the importance of synergy among nutrients. Often there is data manipulation via statistical methods (often in meta-analyses).
Well beyond the question of whether supplements support health are the factors in modern life that create a greater needs for supplementing with important vitamins, minerals, cofactors, and other nutrients.
This month we present “Seven Arguments for Nutritional Supplements.” As the title implies, there are at least seven solid arguments for nutritional supplementation. There are actually a lot more.
To preview these arguments in favor of taking supplements, they are: 1) reduced food quality, 2) nutrient density varies by location, 3) modern lifestyles and stress, 4) environmental pollution, 5) too low RDAs, and 6) promotion of health and delaying of aging, and 7) the human right to correct information.
Essential Fatty Acids (EFA) are one type of essential nutrient required for health.
We at HPDI re-publish articles from the Orthomolecular News Service (OMNS) because the authors provide much needed truth. Truth the form of correcting the false assumptions of anti-supplement propagandists to clarify the benefits of nutritional supplements. This information can help people be healthier easily and at relatively low cost.
HPDI offers a full line of foundational nutritional supplements, including multivitamins, vitamin C and antioxidant formulas, essential fats, and high-RNA Rejuvenate! superfoods. We also offer nearly 100 other nutritional supplements from single nutrients to condition specific formulas. See our full product overview.
Enjoy this article from the Orthomolecular News Service (OMNS). ~
Seven Arguments for Taking Nutritional Supplements
by Dag Viljen Poleszynski, PhD
(OMNS Sept 12 2018)
One of the most vitamin-restrictive countries in the world is Norway. There, authorities limit potencies to only slightly higher than RDA (Recommended Dietary Allowance) levels for dietary supplements sold outside of pharmacies. The traditional reasoning is that most people receive the nutrients they need from a “balanced diet.”
The authorities are also obsessively concerned that some vitamins and minerals are harmful in high doses. And, since an intake of water-soluble vitamins in excess of needs is excreted in the urine, Norwegian “experts” advise that taking supplements is a waste of money.
Accordingly, the argument goes, the public should be protected not only from possible harm, but also from wasting money on unnecessary nutrients. The official policies on nutritional supplements vary within OECD (Organization for Economic Cooperation and Development) countries. Some are more liberal, while others are even more restrictive.
The official view on the connection between nutrient intake and possible toxicity is illustrated by the Norwegian Food Authority in a graph.
Perceived risk from intake of nutrients. (Source: Expert Group on Vitamins and Minerals. Safe upper limits for Vitamins and Minerals. May 2003: Food Standards Agency, UK.)
The graph illustrates the official view on nutrients, assuming that nutrients function in the same way as pharmaceuticals, which they do not. Supplements of most vitamins, but also minerals and other nutrients, do not have very serious side effects even when taken at very high levels – in contrast with most drugs. [3,4] The fact that most of the chemotherapeutic drugs used against cancer have none or even just marginal effects against most cancers , while at the same time cause a lot of serious side effects, is rarely up for discussion.
The idea that nutritional supplements are not safe has a legal underpinning in Norwegian Food Law, which in section 16 prohibits sale of any food which is not safe: “Any food shall be considered not to be safe if it is seen as detrimental to health or not fit for consumption.”
However, the Norwegian authorities do admit that vitamin D supplements are needed during part of the year.  Only part of the year? One third of Norway is within the Arctic Circle. Norway has far too little sunshine (especially during winter months) to get adequate levels of vitamin D from UVB radiation on the skin.
The authorities also recommend that pregnant women take folic acid to prevent birth defects, and omega-3-fatty acids may be advisable for those who do not eat fish regularly. Norwegians have a long tradition of giving children cod liver oil, which in a daily tablespoon provides enough vitamin A and D and essential fatty acids to cover basic needs.
Essential and conditionally essential nutrients
There are thousands of dietary supplements on the market, including 40+ essential nutrients alone and in various combinations, i.e. vitamins, minerals, trace elements and fatty acids. However, a number of other nutrients are “conditionally essential”, meaning that the body normally can make these molecules, but some people do not make optimal amounts. Examples are L-carnitine, alpha-lipoic acid, the methyl donor betaine,  chondroitin sulfate, coenzyme Q10, choline, amino acids such as tyrosine or arginine, and “essential” sugars normally formed in the body.
Healthy young people normally make sufficient amounts of conditionally essential molecules in the body, although the levels are not always optimal. With inadequate levels of minerals or vitamins, key enzymes in biochemical pathways may not function optimally.
Due to genetic mutations, some enzymes may have increased needs for certain cofactors (vitamins), which can prevent them from functioning optimally. Some enzymes only function normally when supplied with cofactors in greater amounts than normally required.
If supplements of essential nutrients prove insufficient for optimal enzyme function, “conditionally essential” nutrients may be added as part of a comprehensive, therapeutic program.
Parents are advised to become familiar with the literature on essential nutrients, for instance by consulting the Orthomolecular News Service. Children should be given supplements in appropriate doses and in a suitable form. Pills should not be given before children can control the swallowing reflex. Multivitamin powder can be given dissolved in water or juice. Parents should not dose vitamin C so high that a child comes to school or kindergarten with loose bowels or diarrhea.
In high doses, niacin may cause unpleasant side effects such as flushing and itching lasting up to several hours.  Although this is not dangerous, it may cause a child to feel unwell and anxious. Starting niacin supplementation with a low dose and gradually increasing it will allow the body to adapt and avoid the niacin flush.
A multivitamin supplement containing moderate amounts of niacin is often adequate until a child is 8-10 years old. For younger children, the dosage should start with only a few tens of milligrams, and not increased to more than 50-100 mg/day. Adults may gradually get used to taking 1,000-1,500 mg/d divided into 3 doses per day.
When it comes to omega-3 fatty acids (omega = ω) such as EPA and DHA, children may be given cod liver oil and served fish and/or other seafood 2-3 times a week. It is important to check the dose of vitamin A supplied, as it can be toxic in high doses, especially for children. One problem with cod liver oil today is that vitamin D has been removed during processing, thus changing the natural ratio of the two vitamins so that we ingest relatively too much of vitamin A.
Higher dosages may be given after having consulted a therapist who has measured the ratio of omega-6 to omega-3 fatty acids in relevant cell membranes (red blood cells). In most industrialized countries, many people get too much of the omega-6 fatty acids, and would therefore benefit from eating more seafood or taking supplements with omega-3 fatty acids derived from organisms low in the food chain (algae, krill).
Flax seeds contain a high level of the essential omega-3 fatty acid alpha-linolenic acid, and freshly ground flaxseed meal or flax oil can be mixed with breakfast cereals or smoothies. Note that it may be advisable to limit eating farmed fish to once per week, since their fodder contains less omega-3 fatty acids than the food eaten by wild fish, and possibly also contains more contaminants.  Some researchers even warn against letting children eat too much fish because of the content of environmental toxins. [13,14]
Reasons for high-dose supplements of micronutrients
I have identified a number of arguments in favor of supplementing the modern diet with essential nutrients, here summarized with seven headlines. Most people should consider taking a multivitamin supplement containing vitamins and minerals even if they eat a nutritionally balanced diet.
Additional nutrients may contribute to better health and, in some cases, can be of vital importance in our modern world. The arguments are presented in random order, i.e. the order does not reflect priority.
1. The agricultural revolution has reduced food quality
The transition from an existence as hunter and gatherers to urban agriculture around 10,000 years ago began an epoch when foods were mass-produced but had lower nutritional density, compared with the previous food eaten by our ancestors. The nutritional density in many foods has fallen significantly since human societies transformed from hunter-gatherers into resident farmers. This is especially true in the last 60-70 years after agriculture was changed from small, versatile ecologically driven family farms to large, chemical-based, industrial agriculture.
The reduction of nutritional content in modern crops, compared with older varieties, is well documented.  It is a consequence of soil erosion, loss of essential minerals from continual heavy use, combined with breeding of new varieties, which has increased the size and growth rate of plants by increasing the content of sugar and water and decreasing their mineral content compared to ancient species. At the same time, the relative content of other macronutrients (fat, protein/amino acids) and antioxidants may have been reduced.
Reduced nutritional density in many foods, combined with the use of refined “foods” like sugar, white flour and refined oils, places a greater priority on eating the most nutritious foods.
Farm produce grown organically generally has higher levels of essential nutrients such as trace minerals because the soil contains higher levels of trace minerals and the produce grows slower and thus has more time to absorb nutrients from the soil. Examples of nutrient dense foods are sardines, wild salmon, shellfish, eggs, liver, kale, collards and spinach, sea plants (seaweed), garlic, blueberries, and dark chocolate.
2. Nutritional content of food varies with geographical location
Nutritional density varies considerably geographically between different regions, even with the same agricultural methods. This was documented in the United States in 1948 by a researcher at Rutgers University in the so-called Firman Bear report.  At that time agriculture was little mechanized, and artificial fertilizers and pesticides were hardly used.
The analysis found large differences in the content of minerals in the same food. The largest variations were found for potassium, sodium, boron and iron in spinach, while the greatest differences in calcium, magnesium and copper content were found in tomatoes.
The soil in areas with relatively low rainfall may in some cases contain an extremely high concentration of minerals, which is reflected in the plants growing there. This was well documented 70 years ago in the book Tomorrow’s Food.  The dentist George W. Heard found that the soil in Hereford, Texas, was exceptionally rich in minerals.
Hereford became known as the “town without a toothache” after a newspaper article from January 29, 1942, reported that Hereford had the lowest incidence of tooth decay of any city in the United States.  Dr. Heard found that people in Hereford had exceptionally few dental cavities and also that the soil locally was especially rich in minerals. He emphasized that the population in the county ate unprocessed food and was drinking raw milk.
Recent research shows that differences in the content of the selenium in the soil can cause major differences in the concentration of selenium in meat.  For instance, since the soil in Finland is poor in selenium, the authorities decided in the early 1980s to add selenate to commercial fertilizers. A survey of selenium status among 108 healthy young people showed an increase in the blood selenium level of about 50 percent after four years.
A similar problem with the level of minerals in the soil exists for the content of magnesium. Often when the soil gets depleted of magnesium from heavy use, this essential mineral is not included in soil amendment with fertilizers. Produce grown in soil with an adequate level of magnesium will contain more magnesium than produce grown in soil deficient in magnesium.
Perhaps as many as 70-80% of the US population is magnesium-deficient, which causes many health problems.  Magnesium supplements (chloride, malate or citrate) can provide an adequate level when vegetables grown in soil with adequate magnesium are not available.
3. Stress and the modern lifestyle increase the need for nutrients
Mental stress increases the excretion and hence the need for many nutrients. Among the most important are magnesium and vitamin C, both of which are used by the body in larger quantities during periods of physical and mental stress. [24,25] Compared with our past as hunters and gatherers, today´s stress is often of a more permanent nature. Instead of experiencing occasional situations where we had to fight or flee, many of us live with recurring stress day in and out.
Vitamin C protects the brain and nervous system from damage caused by stress because the synthesis and maintenance of chemical neurotransmitters such as adrenaline and noradrenaline requires adequate levels of vitamin C.
Vitamin C is also needed to repair collagen which is essential for skin, blood vessels, bones and joints, and muscles. When these are damaged by physical stress, extra vitamin C is necessary.
A controlled trial of 91 adults who experienced increased anxiety and stress 2-3 months after an earthquake in New Zealand in 2011 was divided into three groups, two were given a broad spectrum supplement of micronutrients in low or higher doses.  The supplements were found to alleviate the experience of stress, with the biggest dose having the biggest effect.
Our sedate, modern lifestyle reduces the need for energy from food, which implies a lower food intake or obesity. Loren Cordain, PhD, and coworkers have estimated that hunter-gatherers had significantly higher energy needs than the typical modern office worker.
A lower energy intake generally reduces the absolute intake of all nutrients, while the need for some nutrients is not always reduced proportionally with energy intake. Overall this suggests that more exercise along with a more nutritious diet, including supplements of essential nutrients and less carbohydrates, will help to prevent obesity and maintain health.
Processing of food reduces its nutritional content, and the finished products are often based on fractions of the original foods. One example is milling grain to make white flour,  which has a lower nutritional density than whole grain flour.
The reduction in nutritional value has accelerated since whole foods are now divided into pieces, for example, boneless chicken breast. When meat is injected with saline to increase the volume, the relative level of essential nutrients is reduced. In the United States, many supermarkets in low-income rural and inner city areas have a limited selection of nutrient-dense foods, compared with high-income areas.
4. Environmental pollutants increase the need for nutrients
The need for efficient detoxification and excretion is greatly increased by environmental pollution from the chemical industry, herbicides and pesticides used by industrial agriculture, antibiotic treatment of animals, transport, and plastic packaging.
In our polluted world, the increased toxic load may be compensated for by an increase in nutrients to promote detoxification. One can respond by taking large doses of supplements of essential nutrients, for example, antioxidants vitamin C and E, and an adequate dose of selenium, which help the body detoxify harmful chemicals. Also helpful is regularly taking sauna baths, fasting periodically, and eating an excellent diet that includes generous portions of dark green leafy vegetables and colorful vegetables and fruits.
A recent study predicts that global warming may reduce the nutrient density in many foods worldwide.  Atmospheric CO2 is estimated to surpass 550 ppm in the next 30-80 years, leading to larger crops with lower content of protein, iron and zinc per energy unit.
Assuming that diets remain constant, while excluding other climate impacts on food production, the researchers estimated that elevated CO2 could cause an additional 175 million people to be zinc deficient and an additional 122 million people to be protein deficient in 2050. Anemia would increase significantly if crops lose even a small amount of iron. The highest risk regions – South and Southeast Asia, Africa, and the Middle East – are especially vulnerable, since they do not have the means and access to compensate using nutritional supplements.
5. The RDA for essential nutrients is too low
The recommended nutrient reference intake (NRI) has been defined by UK authorities and the EU Food Safety Agency as the dose that is adequate for 95 percent of the population.  These authorities have given recommendations for a total of 41 chemical substances,  including 13 vitamins, 17 minerals/trace elements, 9 amino acids and two fatty acids. The problem with such guidelines is that when using the same 0.95 fraction for just 16 of the essential nutrients, the fraction of the overall population that has their needs met with the RDA is less than half (0.9516 = 0.44).
Given the above assumption, the proportion of the population having all nutrient needs met falls below 25 percent for 30 nutrients (0.9530 = 0.21). These 25 percent will not necessarily get optimal amounts, just enough so that they probably will have no deficiencies in accordance with established standards. Each individual is different and has different biochemical needs, so we all need different doses of essential nutrients. Many vitamins and minerals can give additional benefit when taken at higher doses.
The need for several essential nutrients increases with age and sickness. This applies, for example, to vitamin C, vitamin D, magnesium, and iron. In 2017 the Norwegian Food Safety Authority proposed to revise the official maximum levels for vitamins and minerals in dietary supplements.
Their proposal introduced four different age categories with separate maximum intakes. Initially, the agencies proposed to revise the daily doses allowed in dietary supplements for folic acid, magnesium, calcium, vitamin C and D. At the same time, maximum rates were temporarily suspended for vitamins A, E, K, thiamine (B1), riboflavin (B2), niacin (B3), pantothenate (B5), pyridoxine (B6), cobalamine (B12), biotin, and for phosphorus, iron, copper, iodine, zinc, manganese, selenium, chromium, molybdenum, sodium, potassium, fluoride, chloride, boron and silicon.
The upper limits for some nutrients may be changed in the future. Unfortunately, Norwegian nutrition “experts” will likely continue to limit allowable doses below those freely available in the US and even Sweden.
6. An optimal nutrient intake promotes health and delays aging
A spokesperson for optimal nutritional intake is the well-known biochemist Bruce Ames, who proposed the “triage theory of nutrients,” in which enzymes responsible for cell maintenance functions evolved to have lower affinity for the essential vitamin and mineral cofactors than the enzymes responsible for short-term survival, to preserve life during times of famine.
Thus, higher levels of vitamins and minerals may delay mitochondrial aging, speed up the repair of large molecules such as DNA and collagen, and generally improve other cellular functions. This is an important rationale for taking higher doses of vitamins and minerals than recommended reference intakes.
Dietary supplements can slow the aging process, in part by reducing the harmful effects of free radicals, known to be involved in many diseases such as cardiovascular disease and cancer.
Naturally occurring hormones and/or supplements of cofactors needed for optimal hormone production in the body can have a significant life-prolonging effect if the body produces less than optimal amounts.  This is especially relevant for those with a genetic predisposition for disease.
An optimum intake of all nutrients is difficult to achieve even for those who eat almost exclusively an excellent diet of nutrient dense foods, such as meat and innards, fish, shellfish, fowl, eggs, nuts, mushrooms, and vegetables, berries and nutritious fruits. Some nutrients such as folic acid or carotenoids in vegetables are absorbed better from processed than unprocessed foods.
Although vegetables are often considered to be a good source of vitamins, for example vitamin A from carrots, vitamin A is only found in animal products such as liver, egg yolk, fish cod and cod liver oil. Although eating raw vegetables is helpful for several reasons (vitamin C, fiber, microbiota), carotenoids (alpha/beta-carotene, lutein, lycopene) in vegetables are less well absorbed from raw than cooked food and better absorbed in the presence of added fat. [38,39].
Nutrients in vegetables are better absorbed when finely chewed, graded, or mashed , and cooking and grinding meat reduces the energy required to digest it  and increases nutrient absorption .
Orthomolecular pioneer Abram Hoffer and Orthomolecular News Service Editor Andrew W. Saul suggested this list of daily intakes of vitamins and minerals.  The Norwegian 2017 recommendations for adult men and women  are given in comparison. Individual needs may vary substantially from person to person and also with health status.
The figures for optimal intake are obtained from the Independent Vitamin Safety Review Panel of physicians, researchers and academics, who concluded:
“People are deceived in believing that they can get all the nutrients they need from a ‘balanced diet’ consisting of processed foods. To achieve an adequate intake of vitamins and minerals, a diet of unprocessed whole foods, along with intelligent use of dietary supplements is more than just a good idea: it is vital.” [44: 55]
A well-known example is vitamin C, which can effectively fight viral infections, prevent or reverse disease caused by bacteria, and help the body detoxify organic and inorganic toxins.  Vitamin C also reduces the risk for cancer, strengthens connective tissues (collagen), and counteracts stress by increasing the adrenal´s production of cortisol. The dose required is set according to the body’s need.
Nobel Price Laureate Linus Pauling suggested that an optimal daily intake of vitamin C could vary from at least 250 mg up to 20 grams per day.  Because unabsorbed vitamin C attracts water into the gut, some people may experience loose stools, gas and/or diarrhea by ingesting only 1-2 grams at a time, while others with a higher level of stress may tolerate 5-6 grams or more. The dose that causes loose stools is called the “bowel tolerance” for vitamin C.  To avoid the laxative effect of high doses, it is best to take vitamin C throughout the day in smaller divided doses.
When the body is stressed by disease, the gut will naturally absorb more vitamin C because the body needs more. To find the optimal dose, the intake should be increased until bowel tolerance is reached. Some people can tolerate more than 100,000 mg/d of vitamin C in divided doses during serious illness without having loose stool.
Liposomal vitamin C bypasses the normal bowel tolerance because it is absorbed directly through cell membranes, so higher doses can be tolerated without diarrhea.
7. A human right to receive correct information
Access to correct information about food and essential nutrients, including knowledge about the importance of food for health is a fundamental human right. Such information should not only provide a summary of the nutrient content of food, but in our opinion should also explain how dietary supplements can counteract deficiencies and prevent and reverse disease caused by nutrient deficiencies.
We should be free to purchase quality-controlled supplements of essential nutrients and to use them to counteract aging and damage from stress as part of a long-term health plan. The right to reject recommendations by doctors for symptomatic treatment with synthetic, some times life-threatening, drugs to alleviate symptoms should be included. [48,49]
I have not found any formulation of such rights from the Norwegian authorities. The role of parents and their right to receive correct health information is addressed in a book by lawyer Anne Kjersti C. Befring, a fellow at the University of Oslo since 2014.
The use of dietary supplements is widespread. High doses of vitamins are thought to be helpful because they help the body recover from damage and maintain itself long-term. Many vitamins are not harmful in doses even 10 to 100-fold higher than officially recommended.
Some governments warn about possible negative side effects, even including increased mortality from “excessive” intake of certain supplements. However, supplements of essential nutrients have been available for more than 80 years. They are known to be safe, and the observed side effects are generally mild with few exceptions.
It is possible to ingest too much of certain vitamins and minerals (vitamin A, calcium, iron, copper, selenium) which may exacerbate an existing imbalance or lack of another mineral (magnesium, zinc). It is also important to balance intake of fatty acids in the omega-6 and omega-3 series, as most people get too much omega-6 and not enough omega-3.
Small children can be overdosed with adult doses of for example vitamin A or iron, and pills may be dangerous for babies or young children because they can get stuck in the throat. Therefore, I recommend consulting a doctor or nutritionist educated in orthomolecular medicine. Most people are likely to benefit from taking a broad-spectrum multivitamin/mineral supplement as a basic insurance against deficiencies.
Compared to pharmaceutical drugs, supplements of most essential nutrients are quite harmless. However, some supplements may have poor quality, or contain toxic metals such as lead or cadmium. Therefore, it is the duty of our authorities to ensure that potentially hazardous products or supplements of poor quality are not sold, and that consumers are offered fair prices in a free market.
An example where the Norwegian authorities do not follow up such basic duties is that pharmacies demand more than 1,600 Norwegian Kroner (about $190) per kg of vitamin C in powder form, which would cost less than $20 with free competition and no restrictions in permitted doses or outlets.
Those who want to use natural healing methods, such as the use of food and supplements of essential nutrients to prevent or reverse illness, should consult therapists who are qualified to give advice on how natural therapies can help.
I recommend that anyone interested in supplements read the references for this article as well as the archives of the Journal of Orthomolecular Medicine http://orthomolecular.org/library/jom/ and the Orthomolecular Medicine News Service http://orthomolecular.org/resources/omns/index.shtml . Both are free access online.
(Dag Viljen Poleszynski, PhD, is the editor of Helsemagasinet [Health Magazine] https://vof.no/arkiv/ . He has translated and published a large number of OMNS releases in Norwegian.)
1. National Nutrition Council. Dietary advice to promote public health and prevent chronic disease. Directorate of Health, Oslo January 2011.
22. Hintze KJ, Lardy GP, Marchello MJ, et al. Areas with high concentration of selenium in the soil and forage produce beef with enhanced concentrations of selenium. Journal of Agricultural and Food Chemistry 2001; 49: 1062-7. https://pubs.acs.org/doi/abs/10.1021/jf000699s
23. Mäkelä AL, Näntö V, Mäkela P, et al. The effect of nationwide selenium enrichment of fertilizers on selenium status of healthy Finnish medical students living in South Western Finland. Biological Trace Element Research 1993; 36: 151-7. https://link.springer.com/article/10.1007/BF02783174
24. Dean C. The Magnesium Miracle. Second Edition. New York: Ballantine Books, 2017. ISBN-13: 978-0399594441
25. Hickey S, Saul AW. Vitamin C: the real story. Laguna Beach, CA: Basic Health Publications, Inc., 2008. ISBN-13: 978-1591202233
26. Rucklidge JJ, Andridge R, Gorman B, et al. Shaken but unstirred? Effects of micronutrients on stress and trauma after an earthquake: RCT evidence comparing formulas and doses. Human Psychopharmacology and Clinical Experience 2012; 27: 440-54. https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.2246
27. Cordain L, Gotshall RW, Eaton SB. Evolutionary aspects of exercise. In: Simopoulos AP, ed.: Nutrition and fitness: Evolutionary aspects. World Review of Nutrition and Diet 1997; 81: 49-60. https://www.ncbi.nlm.nih.gov/pubmed/9287503
28. Zenk SN, Powell LM, Rimkus L, et al. Relative and absolute availability of healthier food and beverage alternatives across communities in the United States. American Journal of Public Health 2014; 104: 2170-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202991/
29. Waldbott GL. Health effects of environmental pollutants. Second edition. St. Louis, MI: The C. V. Mosby Company, 1978. ISBN-13: 978-0801653308
36. Halliwell B, Gutteridge HMC. Free radicals in biology and medicine. 5th edition. Oxford, NY: Clarendon Press, 2015. ISBN-13: 978-0198717485
37. Hertoghe T. The hormone handbook. Copyright (c) 2006 Thierry Hertoghe. Surrey, UK: International Medical Publications, 2006.
38. Edwards AJ, Nguyen CH, You CS, et al. a- og ß-carotene from a commercial carrot puree are more bioavailable to humans than from boiled-mashed carrots, as determined using an extrinsic stable isotope reference method. Journal of Nutrition 2002; 132: 159-67. https://academic.oup.com/jn/article/132/2/159/4687130
39. Unlu NZ, Bohn T, Clinton SK et al. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. The Journal of Nutrition 2005; 135: 431-6. https://www.ncbi.nlm.nih.gov/pubmed/15735074
40. Boback SM, Cox CL, Ott BD et al. Cooking and grinding reduces the cost of meat digestion. Comparative biochemistry and physiology. Part A, molecular & integrative physiology 2007; 148: 651-6. https://www.ncbi.nlm.nih.gov/pubmed/17827047
The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.
Editorial Review Board:
Ilyès Baghli, M.D. (Algeria)
Ian Brighthope, M.D. (Australia)
Prof. Gilbert Henri Crussol (Spain)
Carolyn Dean, M.D., N.D. (USA)
Damien Downing, M.D. (United Kingdom)
Michael Ellis, M.D. (Australia)
Martin P. Gallagher, M.D., D.C. (USA)
Michael J. Gonzalez, N.M.D., D.Sc., Ph.D. (Puerto Rico)
William B. Grant, Ph.D. (USA)
Tonya S. Heyman, M.D. (USA)
Suzanne Humphries, M.D. (USA)
Ron Hunninghake, M.D. (USA)
Michael Janson, M.D. (USA)
Robert E. Jenkins, D.C. (USA)
Bo H. Jonsson, M.D., Ph.D. (Sweden)
Jeffrey J. Kotulski, D.O. (USA)
Peter H. Lauda, M.D. (Austria)
Thomas Levy, M.D., J.D. (USA)
Homer Lim, M.D. (Philippines)
Stuart Lindsey, Pharm.D. (USA)
Victor A. Marcial-Vega, M.D. (Puerto Rico)
Charles C. Mary, Jr., M.D. (USA)
Mignonne Mary, M.D. (USA)
Jun Matsuyama, M.D., Ph.D. (Japan)
Dave McCarthy, M.D. (USA)
Joseph Mercola, D.O. (USA)
Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
Karin Munsterhjelm-Ahumada, M.D. (Finland)
Tahar Naili, M.D. (Algeria)
W. Todd Penberthy, Ph.D. (USA)
Dag Viljen Poleszynski, Ph.D. (Norway)
Jeffrey A. Ruterbusch, D.O. (USA)
Gert E. Schuitemaker, Ph.D. (Netherlands)
Thomas L. Taxman, M.D. (USA)
Jagan Nathan Vamanan, M.D. (India)
Garry Vickar, MD (USA)
Ken Walker, M.D. (Canada)
Anne Zauderer, D.C. (USA)
Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
Robert G. Smith, Ph.D. (USA), Associate Editor
Helen Saul Case, M.S. (USA), Assistant Editor
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Comments and media contact: email@example.com OMNS welcomes but is unable to respond to individual reader emails. Reader comments become the property of OMNS and may or may not be used for publication.
I previously published “Homocysteine Genetics – Coenzyme B Vitamins” in which I considered in-depth how homocysteine (an intermediate chemical in the Methylation Cycle) is formed from methionine, how genetics affects the metabolic pathways, and how B vitamins are used in metabolic pathways. I also wrote “Folate Ingredients – Folinic Acid & 5-MTHF” which discussed how coenzyme folate vitamins are far superior to the synthetic folic acid form. In today’s article, I take a broader view of the topic that encompasses the Methylation Cycle, genetics, and B vitamins.
THE METHYLATION CYCLE
The Methylation Cycle is considered to be one of the most important metabolic pathways in the human body. Its most important function is to provide methyl groups via SAM (S-adenosyl methionine) to hundreds of different body substrates. Methylation is continually occurring in the body, transforming many millions of molecules throughout the body every second. Molecules receive methyl groups, then separate and recombine continuously, transforming and reforming constantly in the ongoing process of life!
As a reminder of the pathways involved in the Methylation Cycle, the following figure provides a flow chart showing the details.
Figure 1. Metabolic Pathways in Methylation Cycle
A key purpose of this cycle is to provide methyl groups (CH3) needed by a broad range of of body functions (over 200 different functions). Examples include:
Influences the genetic expression that parents give their children and helps guide the development of the embryo.
Is needed by the nervous system to produce neurotransmitters and maintain the nerves.
Mobilizes fats and cholesterol so they do not accumulate where they are harmful, such as the arteries and liver.
Regulates hormones, including, estrogen, adrenaline, and melatonin.
Detoxifies harmful chemicals and histamine a prime substance involved in inflammation.
Helps repair damaged proteins in the cells so they can function properly.
Protects the DNA in the genome (genetic code) to reduce the chances of mutation.
Creates antioxidants used in the antioxidant defense system.
DESCRIPTION OF PATHWAYS WITHIN THE METHYLATION CYCLE
The overall flow of the Methylation Cycle begins with dietary methionine (an essential amino acid) which combines with ATP (adenosine triphosphate – body energy) to form SAM (S-adenosyl methionine) – the common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. When SAM transfers a methyl group to a body chemical the residue from this reaction leads to the production of homocysteine.
Homocysteine can be converted in the transsulfuration pathway that requires coenzyme vitamin B6 to produce cysteine, glutathione, taurine, and sulfates. These sulfur containing substances provide important antioxidant protection and detoxification functions in the body.
Homocysteine can be converted back to methionine through the betaine (trimethyl glycine) pathway which requires zinc and magnesium. This pathway also requires dietary betaine or choline which the body can convert into betaine.
Also, homocysteine can be converted back to methionine via the remethylation pathway which requires 5-MTHF, coenzyme vitamin B2 and methylcobalamin (B12).
It is important to understand that each of the pathways described above are able to be executed only in the presence of enzymes (shown in blue boxes in the diagram) created by specific genes in your genetic code. For example, Betaine-Homocysteine S-Methyltransferase (BHMT) is the enzyme required in the betaine pathway, Cystathione Beta Synthase (CBS) is the enzyme required in the transsulfuration pathway, and Methylenetetrahydrofolate Reductase (MTHFR) and Methionine Synthase (MS) are enzymes required in the remethylation pathway.
Assuming that you have perfect genetics (no mutations, SNPs, free radical damage, insertions/deletions, etc.), the proper functioning of these pathways are still subjected to the fact that the required vitamins and minerals (vitamin B6, vitamin B2, Folate, vitamin B12, zinc, magnesium, and betaine) need to be provided by your diet or from supplements for the body to function correctly.
In addition, exposure to high levels of toxins from your environment and high levels of stress require that the nutritional needs will be even higher for the pathways to work properly. For example, exposure to high levels of toxins requires that the transsulfuration pathway be more active possibly reducing the amount of available methionine to support necessary methyl transfer reactions.
For these reasons alone the consensus of knowledgeable practitioners is that you should be eating an organic whole foods diet, taking appropriate nutritional supplements, avoiding and eliminating toxins from food, water, and air (living in a clean environment), and avoiding an unduly stressful life. All of these actions fall into the category of Epigenetics which you generally have control over!! Doing these things alone could significantly balance the functioning of your Methylation Cycle and improve your health.
Unfortunately, few people have perfect genetics which often causes the various pathways in the Methylation Cycle to become imbalanced and unable to correct the dysregulation imposed upon the body. For example, the enzyme MTHFR can have heterozygous (single chromosome) genetic variations in up to 50% of certain populations and homozygous genetic variations (both chromosomes) in 10% or more of certain populations.
Some disorders that researchers have associated with MTHFR genetic variations include:
Chronic fatigue syndrome
High blood pressure
Irritable bowel syndrome
Migraines with aura
Nitrous oxide toxicity
Unexplained neurologic disease
This extensive list is highly significant and tells us that it is very important to have genetic testing done for the genes/enzymes in the Methylation Cycle pathway. I prefer the BodySync genetic test which evaluates the key Methylation Cycle genes plus many other important genes in a single test.
B VITAMINS AND MINERALS
We are strong believers that everyone should start their nutritional program by eating a balanced, organic, whole foods diet. We have been doing this ourselves for the past 30 years. Unfortunately, only a small percentage of people follow this advice and in most cases this leads to poor nutritional status that does not adequately support the body’s needs. This is especially true with respect to obtaining the nutrients needed to support the Methylation Cycle.
Nine of our family members and associates have taken the BodySync genetic test which evaluates the condition of 45 different enzymes including CBS, MTHFR (2 variations), MTR (related to B12 and 5-MTHF as they relate to methionine synthase – MS), and MTRR (related to maintaining B12 levels needed by the MTR enzyme). In every case the results showed at least 2 and up to 4 enzymes had genetic variations. These results indicate that the nutritional requirements for folate as 5-MTHF, vitamin B12 as methylcobalamin, vitamin B6, vitamin B2, magnesium and zinc will likely be significantly greater than normal.
Given the above information, it seems essential for good health to take nutritional supplements that provide the important nutrients. Below I will discuss various formulas that I have developed and refined over many years that are useful especially for the Methylation Cycle.
Please note that Health Products Distributors, Inc. (HPDI) is the preferred supplier of nutritional supplements by the BodySync genetic testing company.
When looking at the total needs the body has for nutrients that the body does not produce, including fat soluble vitamins (A, D (some), E, K1 and K2), vitamin C, B vitamins (B1, B2, B3, B5, B6, folate, B12, biotin, choline, and inositol), minerals (Ca, Mg, Zn, Se, Cu, Mn, Cr, Mo, K, boron, and vanadium), and betaine it only seems wise to include as a top priority a Multivitamin that includes all of these in what I term therapeutic amounts (carefully selected after evaluating thousands of research studies carried out over many years.)
In this context, it is important to recognize that every enzymatic reaction in the body requires mineral cofactors in order to carry out its function. A good multivitamin provides many of these required minerals.
Additionally, the multivitamin should contain ingredient forms that research has confirmed to be the most absorbable and usable by the body. These include coenzyme B vitamins, Krebs cycle (citrate, alpha-ketoglutarate, succinate, fumarate, & malate) minerals, and amino acid chelates.
In the context of supporting the Methylation Cycle we are looking for specific forms and amounts of B vitamins that can adequately provide the body’s needs. The means that there should be coenzyme folate as 5-MTHF of at least 400 mcg, coenzyme vitamin B-12 as methylcobalamin of at least 200 mcg, Vitamin B6 (including significant amounts of pyridoxal 5′ phosphate) of at least 40 mg, and Vitamin B2 (including significant amounts of riboflavin 5′ phosphate) of at least 25 mg. In addition, magnesium (100 mg) and zinc (at least 20 mg) should be provided.
Please note that the body’s requirements for magnesium is generally accepted by nutritional experts to be higher than 400 mg daily (and as high as 1,000 mg daily). For this reason we generally recommend that a person take supplemental magnesium (such as HPDI’s MYO-MAG) at levels over 400 mg daily.
The two multivitamin formulas Health Products Distributors provides for adults that meet these requirements (and more) are the Hank & Brian’s Mighty Multi-Vite and Multi Two (in both capsule and tablet forms). Click on the bottles below for technical details.
In situations where significant genetic variations are present it may be wise to add a B COMPLEX supplement to the MULTIVITAMIN to provide even larger amounts of the needed B vitamins. HPDI provides a B-Complex-50 product that includes significant amounts of coenzyme forms and contains 50 mg of Vitamin B1, 50 mg of Vitamin B2, 100 mg of Vitamin B3, 50 mg of Vitamin B6, 500 mcg of coenzyme folate (both folinic acid and 5-MTHF), 100 mcg of B12 (both methylcobalamin and hydroxocobalmin), 50 mg of Vitamin B5 (pantothenic acid), 500 mg of Biotin, 50 mg of choline, and 50 mg of inositol. Click on the bottle below for technical details.
FOLATE AS 5-MTHF
In situations where an inadequate diet is present and genetic testing indicates an MTHFR variation (especially a homozygous variation) Health Products Distributors provides a 5-MTHF folate supplement that easily absorbs into the body and can be directly used in combination with Vitamin B12 to convert homocysteine to methionine. Click on the bottle below for technical details.
5-MTHF 1 mg in veggie cap
B-12 as METHYLCOBALAMIN
It is often the case for older patients and vegetarians that Vitamin B12 is deficient. In these cases it is wise to supplement with a significant amount of methylcobalamin to ensure that the Methylation Cycle has sufficient to effectively convert homocysteine into methionine. Health Products Distributors Vitamin B12 contains 5 mg of methylcobalamin in sublingual lozenge form that supports excellent absorption even if swallowed and absorbed by diffusion. Click on the bottle below for technical details.
Magnesium and zinc are two important minerals used in the betaine pathway of the Methylation Cycle in which homocysteine is converted back to methionine.
In the body magnesium is involved in more than 400 essential metabolic reactions and is required by the adenosine triphosphate (ATP)-synthesizing protein in mitochondria. ATP, the molecule that provides energy for almost all metabolic processes, exists primarily as a complex with magnesium (MgATP). Therefore, it also is involved in converting methionine to SAM.
Over 300 different enzymes depend on zinc for their ability to catalyze vital chemical reactions. Zinc-dependent enzymes can be found in all known classes of enzymes.
Health Products Distributors provides 100 mg magnesium/vcap in its MYO-MAG supplement which is especially important in increasing ATP in the Krebs Cycle. This product also contains vitamin B1, vitamin B2, and vitamin B6 with substantial amounts of coenzyme forms and manganese. Click on the bottle below for technical details.
MYO-MAG with 100 mg magnesium per serving and key B vitamins.
Health Products Distributors provides 25 mg zinc/serving in its Double Zinc Plussupplement. This formula provides zinc in the picolinate and citrate forms as well as 3 mg of P5P (coenzyme B6). Click on the bottle below for technical details.
Double Zinc Plus supplement with P5P and 25 mg zinc
The Methylation Cycle is recognized as one of the most important metabolic pathways in the human body. When not properly supported by key B vitamins and minerals, the Methylation Cycle can become severely imbalanced which can lead to a very wide range of poor health conditions. Furthermore, genetic variations in the genes that produce important enzymes allowing the Methylation Cycle to function correctly lead to even further imbalances and greater possibility for conditions of poor health.
In this article, I have provided insight into how the Methylation Cycle works and how it can be significantly supported by lifestyle changes regarding diet and environment (Epigenetics) and by specific B vitamins and mineral supplements that I have developed over many years. In addition, we have shown that knowledge gained from genetic testing can further provide a critical understanding of your specific needs so that your health can be optimized.


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Annual Care Packages
Every pet owner has something in common with Access Veterinary Care - we both want your pet to get everything they need to stay health, happy, and excited about life. With that in mind, we offer several Annual Care Packages that include everything recommended to keep your pet's as healthy as possible and detect problems early. Whenever recommended by American Animal Hospital Guidelines, we use 3-year vaccine protocols to ensure Fluffy gets the protection she needs - and nothing she doesn't.
- Canine Gold-Standard Wellness: $125
- Includes: Complete physical exam, heartworm testing, fecal exam, recommended updates on all core vaccines (Rabies, Distemper/Parvo/Hepatitis, Leptospirosis)
- Canine Social Wellness: $165
- Recommended for all dogs who socialize (boarding, day care, grooming, etc.). Includes Bordatella and Influenza vaccination in addition everything in the standard package.
- Feline Indoor Gold-Standard Wellness: $80
- Includes: Complete physical exam, fecal exam, recommended updates on all core vaccines (Rabies, Feline Viral Rhinotracheitis, Calicivirus, Panleukopenia)
- Canine/Feline Annual Wellness Bloodwork (Recommended for pets 7+): Add $55-60
- Wellness Screening Bloodwork to check the liver, kidneys, blood counts, etc. for early detection of disease.
We also provide all wellness clients with a Pet Health File to organize all their physical records, and we update it at each visit. Pet ID Cards and online portal access is provided annually as well.
Puppies & Kittens
We offer special pricing for those situations that require "return visits" - such as new puppies, kittens, and pets that need a second booster of a given vaccine.
- New Puppy/Kitten Package: $285 /$245
- Two to four complete veterinary exams over the course of the initial vaccine series, plus a free semi-annual exam to check in mid-year.
- A complete series of all recommended core vaccinations, including Bordetella for puppies.
- Kittens receive Feline Leukemia testing & vaccination following AHAA and AAFP guidelines.
- Broad-spectrum deworming is performed at every visit and fecal examinations are done at least up to twice.
- Your pet's first nail trim, with a demo on how to do it at home.
- Dental Starter Kit and demo on toothbrush training.
- First dose of heartworm prevention and flea/tick prevention.
- Copy of "How To Behave so Your Dog Behaves" for puppies to start training right.
- A Pet Health File and wallet ID Card.
- Substantial discounts for Microchip placement and Canine Influenza vaccination
- Puppy/Kitten Visit (No Package): $90-150 per visit, varies based on age/needs. Packages represent a significant savings ($100-300) and are recommended, but not required.

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UV and Skin
Sensitive skin and UV: the dangers of daily sun exposure
For most people, the sun is a universal symbol of positivity, the most natural phenomenon of mood-booster. And yet, 365 days a year, regardless of summer or winter, sun exposure appears as our skin’s biggest enemy.
On your morning commute or during a quick lunch-break, even though with strong cloud cover, the UV rays will still reach your deeper skin tissues and triggers the following side effects:
- With the high temperature heat induced by the sun rays, the skin will be irritated while accompanied by redness and discomfort.
- UVA and UVB rays then set off oxidative stress, leading to micro-inflammation.
- This causes blood vessels to dilate and nerve endings to fire off pain signals.
- The sun rays thus cause dehydration to your skin’s superficial layers, damaging its protective film and leaving it exposed to external aggressors.
- UV also act as a pro-oxidant tag team with pollution particles, further worsening the oxidative stress and irritation within your skin.
- Long term, long-UVA, which are particularly present throughout the day regardless of the weather, exacerbates the skin’s sensitivity and accelerates darkening.
Sun protection is not just for the beach.
Daily exposure to sunlight is the skin’s top stressor which detracts your skin quality as well as its uniformity.
What Are The Criteria Which Makes The Best Sun Care For Your Skin?
1. First of all, ensure your sunscreen comes in a silky, lightweight, spreadable texture to avoid excessive rubbing.
2. Make sure that your sunscreen contains a high protection, broad spectrum UVA-UVB filter with SPF 30 plus long-UVA protection.
3. Lastly, it has been tested on sensitive and sun-allergic skin and free of irritant and paraben.
Further, it is enriched with Hyaluronic Acid and Ceramide which immerse the skin with a protective layer of lipid while sustaining the skin’s natural healthy functions and restoring its vital moisture.
The good news is: Our innovative Timeless Sun Care fulfills all the above criteria and it is encapsulated in formulation with a potent effective array of anti-oxidants and skin restoring ingredients to safeguard our skin from environmental damage.
Don’t feel like using foundation every day?
Timeless Sun Care is also a multitasking sunscreen that melts into your face like a second skin. It diminishes discoloration, reduces signs of sun damage while acting as a non-makeup makeup base. As it calms sensitive and irritated skin, it certainly offers as a great alternative to makeup foundation for sensitive and acne prone skin.
Besides, Timeless Sun Care is also composed of highly concentrated Vitamin C which has shown to deliver amazing skin lightening benefits. As such, it increases the skin protection against free radical attacks from UVA & UVB rays while accelerating wound healing for photo-damage skin.


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Heck if anything show up and interact for a fun time and a drawing for some free stuff just for showing up and commending during the FB Live event!
Can’t wait to see you there! And if you want to learn more about connection essential oils to your whole health contact me at email@example.com so we can set up a private session. Or message me on Facebook.
You can also learn more about essential oils at www.mydoterra.com/kellyfrick


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This luxurious, shimmery blue mask supports the skin’s ability to resist stress that contributes to the visible signs of skin aging.
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How is Planet Fitness better (and worse) than other gyms?
How is Planet Fitness better than other gyms ?Introduction:
In a market saturated with fitness options, the decision to choose the right gym involves nuanced evaluation. Planet Fitness has gained attention for its unique approach to the fitness industry. This article explores the features that set Planet Fitness apart, considering both the positive aspects and potential shortcomings compared to other gyms.
Affordability and Accessibility:
Planet Fitness is widely recognized for its commitment to making fitness accessible to everyone. With a reasonable monthly fee and straightforward approach, it removes financial barriers, helping individuals achieve fitness without putting a strain on their budget.
Adopting a “judgment-free zone” ethos, Planet Fitness promotes inclusivity. This philosophy creates a welcoming space for individuals of all fitness levels, removing the intimidating gym culture often associated with other fitness establishments.
Comprehensive Cardio Equipment:
Planet Fitness offers a diverse range of cardio equipment to ensure effective cardiovascular workouts. A variety of treadmills, elliptical machines, and stationary bikes cater to different fitness preferences.
Recognizing the demands of modern lifestyle, Planet Fitness offers 24/7 access, accommodating early birds, night owls and everyone in between.
Limited Strength Training Equipment:
Planet Fitness emphasizes simplicity, which may be a drawback for those looking for a more comprehensive selection of weights and resistance machines for strength training.
Lack of personal training programs:
Unlike some competitors, Planet Fitness doesn’t prioritize personal training programs, which limits options for those wanting a tailored workout plan and guidance.
“Lunk Alarm” controversy:
“Lunk alarms” designed to discourage loud behavior have sparked controversy. Some argue that this may discourage serious fitness enthusiasts from creating a focused environment.
Additional charges for some features:
While offering a basic membership at a low price, Planet Fitness charges extra for amenities like massage chairs or tanning beds. This à la carte approach may not appeal to those seeking an all-inclusive experience.
Planet Fitness has carved a unique niche with its affordability, inclusivity and accessibility.
However, its limitations in strength training equipment, personal training programs, and controversial policies may lead fitness enthusiasts to consider other options.
Ultimately, the choice between Planet Fitness and other gyms depends on personal preferences, emphasizing the importance of considering personal fitness needs and values when selecting a fitness center.
Q1: What makes Planet Fitness stand out in the fitness industry?
A1: Planet Fitness stands out for its affordability, inclusive atmosphere, and commitment to providing a judgment-free zone where individuals of all fitness levels feel welcome.
Q2: Does Planet Fitness offer personal training programs?
A2: No, Planet Fitness does not prioritize personal training programs. While the gym offers a supportive environment, individualized training is not a central feature of its services.
Q3: Can I access Planet Fitness facilities at any time of the day?
A3: Yes, Planet Fitness provides 24/7 access to its facilities, allowing members to work out at their convenience, whether early in the morning or late at night.
Q4: What is the controversy surrounding the “Lunk Alarm” at Planet Fitness?
A4: The “Lunk Alarm” is designed to discourage loud and intimidating behavior. However, it has sparked controversy, with some arguing that it may discourage serious fitness enthusiasts from creating a focused workout atmosphere.
Q5: Are there limitations in strength training equipment at Planet Fitness?
A5: Yes, Planet Fitness may have a more limited selection of strength training equipment compared to some other gyms. The focus is often on providing a simple and approachable fitness experience.
Q6: What amenities at Planet Fitness may come with additional charges?
A6: While Planet Fitness offers a basic membership at a low cost, certain amenities such as massage chairs or tanning beds may come with extra charges.
Q7: How does Planet Fitness create an inclusive environment for members?
A7: Planet Fitness fosters inclusivity through its “Judgment-Free Zone” philosophy, aiming to eliminate intimidation and create a comfortable space for individuals of all fitness levels.
Q8: Does Planet Fitness provide individualized workout guidance or assistance?
A8: While staff may be available to assist, Planet Fitness does not prioritize personal training programs, and individualized workout guidance is not a central focus.
Q9: Are group fitness classes offered at Planet Fitness?
A9: While policies may vary, Planet Fitness typically emphasizes individual workouts, and group fitness classes may not be as central to its offerings.
Q10: Can I bring a guest to Planet Fitness?
A10: Many Planet Fitness locations allow members to bring a guest, either for free or at a nominal fee, promoting a social and supportive fitness environment.
Q11: Does Planet Fitness offer trial periods for potential members?
A11: Some Planet Fitness locations may offer trial periods or day passes for prospective members to experience the facilities before committing to a membership.
Q12: What potential drawbacks should individuals consider when choosing Planet Fitness?
A12: Drawbacks may include limited strength training equipment, the absence of personal training programs, and additional charges for certain amenities beyond the basic membership fee.
Q13: How does Planet Fitness cater to individuals with specific fitness goals?
A13: While Planet Fitness aims to cater to a broad audience, it may not be as tailored to individuals with specific fitness goals, such as advanced strength training or specialized training programs.


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For All Skin Types
Black Tea Grass Jelly Anti-oxidant Moisturizer effectively soothe the skin while also providing intense protection against free radicals.
Formulated to sink deep into the skin, this moisturizer combats signs of aging by nourishing skin with powerful hydration and beneficial antioxidants so skin looks firmer, brighter, and more youthfully radiant.
Pu erh black tea is concentrated with protective antioxidants.
Just as sunblck protects the sun, black tea protects against and. reverse damages from free radicals that cause signs of aging.
Grass Jelly is a reparative concoction of hydrating plant saccharides and super soothing tiger grass.
Q. What are the benefits of using the Black Tea Grass Jelly Anti-oxidant Moisturizer?
A. The Black Tea Grass Jelly Anti-oxidant Moisturizer is designed to provide hydration to all skin types while also protecting your skin from environmental damage. It helps to improve skin texture and firmness, while also providing essential nutrients to protect your skin from premature aging and free radicals.
Q. How do I use the Black Tea Grass Jelly Anti-oxidant Moisturizer?
A. Apply a small amount of the Black Tea Grass Jelly Anti-oxidant Moisturizer to your face and neck after cleansing and toning. Massage the cream gently into your skin until it is fully absorbed. For best results, use morning and night.
Q. Is the Black Tea Grass Jelly Anti-oxidant Moisturizer suitable for sensitive skin?
Q. Can I wear makeup over the Black Tea Grass Jelly Anti-oxidant Moisturizer?
A. Yes, you can wear makeup over the Black Tea Grass Jelly Anti-oxidant Moisturizer. It creates a smooth base that helps your makeup to glide on easily and stay in place throughout the day. However, if you have extremely oily skin, you may want to use a mattifying primer or powder to help control shine.
Apply onto cleansed skin for instant, long lasting hydration.
1.7 fl oz / 50 ml
Made in USA
COMPLETE LIST OF INGREDIENTS:
Organic Aloe Barbadensis (Aloe) Leaf Juice, Helianthus Annuus (Sunflower) Seed Oil, Vegetable Glycerin, Organic Camellia Sinensis Leaf (Black Tea) Extract, Tocopherol (Vitamin E), Organic Rosa Damascena Flower (Rose) Water, Olive Squalane, Lauryl Glucoside (Plant Derived), Myristyl Glucoside (Plant Derived), Polyglyceryl-6 Laurate (Plant Derived), Caprylhydroxamic Acid (Coconut Derived), Glyceryl Caprylate (Plant Derived), Epigallocatechin Gallate (Green Tea EGCG), Sodium Hyaluronate (Hyaluronic Acid), Polyglutamic Acid (Natto Beans Derived), Panax Ginseng Extract, Centella Asiatica (Gotu Kola) Extract, Bakuchiol, Morus Alba (Fuji Mulberry) Root Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Lycium Barbarum (Goji Berry) Fruit Extract, Camellia Oleifera Seed Oil, Pelargonium Graveolens (Geranium Flower) Oil, Rosa Damascena (Rose) Flower Oil, Lavandula Angustifolia (Lavender) Flower Extract, Xanthan Gum (Polysaccharide)
Natural ingredients may vary in color and consistency


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Keeping inmates active and healthy is more than just a humanitarian effort; it also helps maintain peace and order within prison walls. Physical activities can reduce inmate-on-inmate violence, improve mental health, and boost self-esteem. As such, fitness is critical in any correctional facility.
Fitness Program Using Correctional Fitness Equipment
Designing a fitness program using correctional fitness equipment for inmates is a multifaceted process that requires careful planning and consideration of various factors. Such a program aims to promote physical health, rehabilitation, discipline, and well-being among incarcerated individuals. Here‘s a more detailed expansion on how to design such a program:
1. Assess Inmate Needs and Goals
Start by comprehensively assessing the inmates’ fitness levels, health conditions, and individual goals. This assessment should consider factors such as age, physical limitations, medical conditions, and the length of their incarceration. Understanding their unique circumstances will allow you to tailor the program to their needs.
2. Select Appropriate Equipment
Choose correctional fitness equipment that aligns with the identified needs and goals of the inmates. Ensure that the selected equipment is suitable for their fitness levels and safe, durable, and resistant to tampering or misuse, which is particularly crucial within a correctional facility environment. Click here to learn more about what equipment is specifically designed to be utilized in a prison setting.
3. Create a Structured Exercise Plan
Develop a structured exercise plan encompassing a wide range of exercises and activities. These should target different muscle groups and fitness components, including strength, endurance, flexibility, and balance. A well-rounded program helps inmates improve their overall fitness and reduces the risk of injury.
4. Set Realistic Progression Goals
Establish short-term and long-term fitness goals that are both realistic and achievable for the inmates. These goals serve as motivators and benchmarks for measuring progress. Tailor the goals to each individual’s abilities and limitations, ensuring they are challenging yet attainable.
5. Incorporate Safety Measures
Prioritize safety by providing clear and detailed instructions on equipment usage and proper exercise techniques. Inmates should be educated on the correct form and posture to prevent injuries. Encourage using spotters, especially during exercises involving heavy lifting or resistance.
6. Implement Supervision and Monitoring
Assign qualified fitness personnel or trainers to supervise and monitor the program regularly. These professionals can ensure that inmates are following the program correctly and safely. Regular assessments and progress tracking help adjust the program to meet individual needs and challenges.
7. Include Warm-Up and Cool-Down
Integrate warm-up and cool-down routines into each workout session. Warm-ups prepare the body for exercise by increasing blood flow and flexibility, reducing the risk of injury. Cool-downs help with relaxation and reduce post-exercise soreness, enhancing overall recovery.
8. Promote Consistency and Routine
Establish a consistent workout schedule and emphasize the importance of routine. Consistency is crucial for achieving fitness goals and maintaining motivation. Inmates should understand the benefits of regular exercise and make it a part of their daily lives.
9. Offer Variety and Novelty
Keep the program engaging by introducing a variety of exercises and workouts. Incorporate new exercises, change routines, or organize fitness challenges to prevent monotony and keep inmates motivated and interested.
10. Emphasize Rehabilitation and Recovery
Integrate specific exercises and therapeutic interventions into the program for inmates with injuries or rehabilitation needs. Collaborate closely with medical staff to ensure rehabilitation efforts align with medical recommendations, promoting inmates’ physical recovery.
11. Promote Positive Behavior and Discipline
Use the fitness program to instill positive behavior, discipline, and teamwork among inmates. Encourage a supportive and respectful environment during workouts, fostering a sense of community and shared goals.
Choosing Suitable Correctional Fitness Equipment
Selecting suitable correctional fitness equipment is a critical decision that should be made with careful consideration of several factors.
- Fitness Levels of Inmates: Consider the varying fitness levels of the inmates within the correctional facility. Some individuals may be beginners, while others may have more advanced fitness capabilities. Ensure that the chosen equipment caters to various fitness levels, offering entry-level and more challenging options.
- Available Space: Assess the space within the facility designated for fitness activities. Different types of equipment require varying amounts of space. Ensure that the chosen equipment can fit comfortably within the allocated area and allow for safe and effective workouts.
- Program Requirements: Define the specific fitness program requirements you intend to implement. For example, cardio machines like stationary bikes or elliptical trainers may be essential if the program focuses on cardiovascular fitness. Weight-lifting equipment such as resistance machines or free weights might be necessary if strength training is a priority.
- Durability: Correctional fitness equipment needs to be exceptionally durable. Inmates may use the equipment regularly, and it should withstand heavy use without breaking down or becoming unsafe. Look for equipment made from high-quality materials like heavy-duty steel to ensure longevity.
- Low-Maintenance: Maintenance requirements should be minimal to reduce disruptions in the fitness program. Choose equipment that is easy to clean and maintain. This can help ensure the equipment remains in good working condition over time.
- Versatility: Versatile equipment is valuable in a correctional setting. Look for products that offer a wide range of exercise options. For example, resistance bands and yoga mats can be used for various exercises, making them versatile additions to the fitness facility.
- Safety Features: Prioritize safety when selecting equipment. Ensure the chosen products have safety features such as tamper-proof fasteners and secure locking mechanisms to prevent misuse or accidents. Instructions and training should also be provided to inmates to promote safe usage.
- Budget Considerations: Stay within the allocated budget for fitness equipment. While durability and quality are essential, managing costs effectively is also important. Compare prices, consider warranties, and make informed decisions that balance quality with budget constraints.
- Accessibility: Ensure the selected equipment is accessible to all inmates, including those with mobility challenges or disabilities. Consider the ergonomics and adjustability of the equipment to accommodate diverse user needs.
Measuring Progress of Inmates
Progress measurements help determine if the fitness program is achieving its goals. These measurements can be quantitative, such as increased strength or endurance, or qualitative, such as better mood or enhanced well-being. Instructors should regularly collect, analyze, and present these measurements to motivate inmates and to inform program adjustments.
Incorporating Mental Fitness
A comprehensive inmate fitness program should also address mental health. Activities like yoga, mindfulness, and meditation can improve mental well-being. Implementing this aspect of fitness in a prison environment can lead to decreased incidents of violence, better inmate behavior, and a more peaceful atmosphere.
Designing a fitness program for inmates can be complex, involving a high degree of planning and execution. However, a successful program with the right corrective fitness equipment, a well-structured schedule, a diverse set of activities, and regular progress measurements may be within reach.


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"The health benefits of blueberries are almost endless but paired with the well known advantages of green tea, makes this delicious beverage an incredible health kick and vitamin boost for your body.
Serve: Hot or Cold
Measure: 1 teaspoon (3gm) to 1 cup (300mL)
Time: 3 minutes
Ingredients: Organic Sencha, freeze dried blueberries, cornflowers.
Success! Feel free to
or head to your


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Your time is valuable. You try your best to save time by using apps, curbside grocery pickup, dry cleaning delivery and so much more. But, have you ever thought of how much time you spend on small lifestyle tasks?
The average woman will spend 70 hours in her lifetime shaving her legs. That’s almost 3 full days of just shaving your legs. Add in the time spent on your underarms, bikini area and any other bodily regions that your maintenance routine covers and the results are baffling! Now that we’ve convinced you that your time is worth it, when is the best time for laser hair removal?
The dreary, damp fall and the frigid winter temperatures are not often associated with bare skin. However, the fall and winter months are the best time for laser hair removal. This is mostly due to the convenience of avoiding the elements and processes that become necessary during the spring and summer time.
The professional administering your treatment will advise on what restrictions to follow weeks before your treatment. Some physicians recommend that you avoid sunlight for approximately 4-6 weeks before you undergo a laser treatment. In addition to avoiding UV lights, you should refrain from waxing or tweezing hair for a period of time as well. However, shaving is very acceptable. In fact, it is recommended that you shave before your treatment in order to encourage new growth in the follicle.
Just as with pre-treatment, during your post-treatment care you should refrain from tweezing or waxing the treated hair. Taking proper precautions to avoid sun exposure is also a best practice for several weeks after the removal procedure.
If you are ready to make the investment to benefit your time, make your laser hair removal appointment today with Dr. Wooming by calling 972-661-5476 or request an appointment online.


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Rosaliac (5 products)
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Canine CryoprecipitateThis page contains information on Canine Cryoprecipitate for veterinary use.
The information provided typically includes the following:
- Canine Cryoprecipitate Indications
- Warnings and cautions for Canine Cryoprecipitate
- Direction and dosage information for Canine Cryoprecipitate
Canine CryoprecipitateThis treatment applies to the following species:
FOR INTRAVENOUS USE IN DOGS ONLY
Caution: This blood component may only be used by or on the order of a licensed veterinarian.
Canine Cryoprecipitate Indications And Usage
Canine cryoprecipitate, lyophilized, is indicated for the treatment of inherited coagulopathies and von Willebrand’s crisis or prevention. Cryoprecipitate can also be used as a topical hemostatic in surgery or dental procedures. Administration of this product is a temporary means of support and not intended to permanently alleviate clinical signs of coagulopathies or von Willebrand’s crisis.
Canine cryoprecipitate is recommended for intravascular administration through either a Hemo-Nate (or equivalent) filter or standard blood administration set. Topical application is recommended to control bleeding during surgery or dental procedures. This solution may be administered in conjunction with or combined with whole blood, pRBCs, plasma, saline and glucose. The solution is isotonic when rehydrated. It is not recommended to co-administer this product with any blood product or IV fluid other than 0.9% sterile saline.
For IV administration, we recommend administration by syringe with an extension set and catheter. Specifically, connect the male end of the syringe into the female end of the Hemo-Nate filter. Connect the male end of the Hemo-Nate filter into the female end of the extension set. Administer at a rate of 2-5 ml/kg/hour based on recommended dosages. A small amount of 0.9% NaCl may be used to “flush” the cryoprecipitate through the extension set and into the catheter.
If this product is given as a pretreatment for coagulopathy before surgery, it should be given within two to four hours of the event. This dose may be repeated every thirty minutes during highly invasive surgical techniques to maintain normal coagulation.
Topical application is recommended to control bleeding during surgery or dental procedures.
The cryoprecipitate should be transferred by syringe and applied directly to the site of hemorrhage.
One vial of lyophilized cryoprecipitate has an approximate minimum equivalency to a 250-300 milliliter unit of fresh frozen plasma (FFP). There is no research confirmed standard dosage for cryoprecipitate but the current literature recommends an empiric dosage of 1 unit of cryoprecipitate obtained from a 250 ml bag of FFP for each 10-12 kilograms of body weight. Extrapolating equivalency dosages yields a dosage of one vial of lyophilized cryoprecipitate for every 12 kilograms of body weight. As the severity of coagulaopathy’s varies between patients, it is up the clinician’s careful judgment to determine an appropriate dose for each individual patient.
Product should sit at room temperature for 5-10 minutes before adding diluent. Do not use needles larger than 20 GA as septum coring may result. Canine cryoprecipitate, lyophilized, should be rehydrated by adding 70ml of 0.9% sterile saline. Mix by swirling and gentle inversion of the product until all powder is rehydrated. Once diluent is added, the vial may be warmed in a 37°C (98.6°F) water bath to speed rehydration. Put in water tight plastic bag to protect injection port. DO NOT EXCEED 15 MINUTES IN 37°C OR TEMPERATURES GREATER THAN 37°C.
A history of anaphylaxis to plasma containing products is a contraindication for use. If necessary, minor crossmatch should be performed to support compatibility.
Warnings And Precautions
This product must be used within twenty-four (24) hours of rehydration to assure stability of the coagulation factors, particularly factor VIII.
Due to the delicate nature of clotting factors it is recommended that this product be rehydrated immediately before use. Allowing it to sit in a rehydrated state, over time, will result in decreased potency due to clotting factor degradation.
DO NOT use sterile water for rehydration of this product.
This product is made from source canine donor plasma. As with all blood products and components there is a risk of infectious disease. The risk has been minimized by prescreening donors and carefully monitoring for bacterial and fungal growth through culture and endotoxin evaluation during processing. All source plasma must meet in-house infectious disease standards which includes donors free of Dirofilaria, Lyme, Babesia, Anaplasma, Ehrlichia, Rocky Mountain Spotted Fever, Hepatozoon, Leishmania, Neorickettsia, Bartonella and hemotropic Mycoplasmas (Mycoplasma haemocanis and Candidatus mycoplasma haematoparvum). However, owners of patients should be made aware of the use of cryoprecipitate and its possible side effects. All infections thought by a veterinarian possibly to have been transmitted by administration of this product should be reported to the Department of Veterinary Services at Animal Blood Resources International, 1-800-243-5759.
Potential reactions to canine cryoprecipitate in recipient dogs may include nausea, peripheral vasodilation and urticaria. Individual anaphylactic reactions cannot be ruled out but are considered extremely rare.
Canine cryoprecipitate, lyophilized, is made from a controlled thaw of source pooled fresh frozen plasma from active donors in the ABRI donor population. It is a sterile, nonpyrogenic white to pale amber powder. It contains a concentration of the cold insoluble portion of plasma containing approximately 50% Factor VIII, 20% fibrinogen and some Factor XIII, vWF and VIIIc. More specifically, each 70 ml reconstituted unit contains a minimum of 150 mg fibrinogen, 80 IU von Willebrand’s factor and 80 IU Factor VIII derived from a 250-300 ml equivalent unit of canine fresh frozen plasma. It is produced without preservative. All source plasma must meet CDFA and in-house infectious disease standards. Canine cryoprecipitate does not contain DEA isoagglutins; therefore, blood typing is not required prior to administration. If the patient has received multiple plasma transfusions, a minor crossmatch is recommended to support compatibility.
This product is shipped refrigerated or frozen. Canine cryoprecipitate should be stored at 4-6°C (refrigerated) until use. Product, before rehydration, is stable for 18 months as labeled.
Refrigerated storage of rehydrated product is required if the product will not be administered within two hours. Rehydrated product should be discarded after 24 hours as stability of the coagulation factors cannot be validated beyond 24 hours.
Canine Cryoprecipitate is prepared and supplied by Animal Blood Resources International, PO Box 609, Stockbridge, MI 49285
P.O. BOX 609, STOCKBRIDGE, MI, 49285
Copyright © 2023 Animalytix LLC. Updated: 2023-02-28


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