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REFILL PURCHASE: The Boost Hair & Body Wash refill pack arrives in a 100% biodegradable pouch from our partner On Repeat. Please decant the refill into your empty Boost Hair & Body Wash bottle as soon as you receive it.
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Some owners saw improvements in their pups’ digestion and general health after switching to Ollie. K9 of Mine is reader-supported, which suggests we could earn a small fee by way of products bought using hyperlinks on this web page. Ed Malaker is a veteran writer who has contributed to a variety of blogs that cowl instruments, pets, guitars, health, and laptop programming.
It’s a high-protein formulation to offer your dog the energy he wants and help him maintain lean muscle mass as he grows via the pet stage. These kibbles are also fortified with assured reside probiotics for digestive and immune health and the DHA comes from mega-rich fish oil to nourish his brain and vision development. This dry pet meals does comprise grains and is out there in an 18-pound bag, a 34-pound bag, and a 47-pound bag. You’ll often see certain canine meals labeled for small, medium and large breeds — these labels principally take care of the dimensions of the kibble and whether it’s easy for them to ingest. Some brands like Royal Canin supply breed-specific formulation, which may help sure breeds’ needs. “Manufacturers that follow dietary science have developed diets with ingredient content material for specific courses of breeds who’re predisposed to sure issues. Many giant and large breeds can develop joint problems in life — some of which are linked to certain elements — and diets labeled ‘giant breed’ take this into consideration,” Roberts stated.
One of one of the best ways to determine out one of the best dog food for your pup is thru the ingredient record — however it would not at all times provide the whole picture, specialists advised us. Combine this pet kibble with Eukanuba Puppy Wet Dog Food and Eukanuba Puppy Healthy Extras for a whole meal.
Salmon and other seafood flavors could contain greater ranges of omega-3 fatty acids, which are found in fish oil. Chicken meal – a highly-concentrated form of protein that is considered good high quality when from a named source. That’s as a result of bigger breeds can suffer from joint problems like hip dysplasia as they age. As puppies, their fast-growing bones need further calcium for correct growth.
The Low Down on Best Dog Food For Puppies Exposed
As long as your chosen pet food meets the factors for a quality dog food, and consists of an AAFCO label, you’re heading in the good dog food for puppy best direction. Some dogs are perfectly happy with kibble while others prefer moist dog food or a combination.
Vet-trained consultants can be found to make recommendations and an online feeding calculator offers portion suggestions. It’s packed with antioxidants and fiber, which support your child’s digestive and immune techniques to make sure he receives all of the vitamins he needs to develop daily. Puppies must be taken on two or three walks a day, and they should have plenty of time to run and play. We independently analysis, take a look at, review, and recommend the most effective products—learn more about our process.
Royal Canin complies with the AAFCO diet tips and it’s very transparent with the ingredients, feeding guidelines and caloric content material of the meals. Wellness makes use of whole ingredients in its complete catalog, and contains meals acceptable for most diets, sizes and life levels.
But puppies and naturally, canines, end up being expensive to care for, so it’s all the time useful to find methods to save money. Considering that one of the most significant expenses is dog food, it might possibly make proudly owning a puppy more manageable if you can find good puppy meals that won’t empty your pockets too much. In specific, DHA plays a vital function in your puppy’s mind and immune system improvement. Omega fatty acids are essential for healthy eye function in young, rising puppies and as a plus, they may assist your pet have a softer, shinier coat. The downside to Royal Canin is that it’s fairly expensive, particularly when you have multiple puppy. It accommodates rooster by-product as its first ingredient, which is decrease quality meat that we usually attempt to keep away from, particularly when feeding puppies. Royal Canin Medium Puppy Dry Dog Food is a high-protein meals formulated to be extremely digestible so your pet can rapidly obtain the vitality and nutrients it wants.
So, if that’s what you’re looking out for, ensure to scan the reviews above for our top picks in this class. Based on the nutrient evaluation, the minimum percentage of crude protein is 27%. In comparability, the percentage of crude fat and crude fiber is 14% and 4%, respectively. Furthermore, this product incorporates calcium, phosphorus, selenium, vitamin E, omega-3 & omega-6 fatty acids, glucosamine, and chondroitin sulfate. Overall, the shopper critiques are constructive for this top-rated giant breed puppy food.
Dry food can be a good choice for puppies who are already at a wholesome weight. There are a few things to consider when making this choice, similar to your pet’s age, exercise stage, and overall health. If you’re unsure of what sort of food to feed your puppy, consult together with your veterinarian. If you present all of this stuff on your pet, they may develop up to be a cheerful and healthy dog. Finally, you want to make positive that the food is wealthy in nutritional vitamins and minerals. When you’re looking for the best puppy pet food, there are a few things that you should remember.


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We want to stand apart from the crowd as the ones with shiny brighter whiter teeth. Do you wonder what chance we got to take in order to achieve the desired results for teeth whitening? Tried all the local products to make your teeth whiter but failed by the results? Do you wonder what keeps away your teeth from unwanted stains, plaque, tartar and gum diseases? Questions go endless but what is the answer! Well, an amazing solution for getting white teeth is using whitening strips.
What is a teeth whitening strip?
Teeth whitening strips are small, tiny pieces of polyethylene. The tiny piece is coated with a gel that contains formulations which can act on the stains of tooth and remove them. Many types of whitening strips are available in the market from various companies. Some of the famous and reliable teeth whitening strip manufacturing companies in the market are crest teeth whitening strips, Listerine teeth whitening strips etc.
Teeth whitening strips – how much it cost?
Teeth whitening strips are easy to use and it is very cost effective. Depending on the brand and product teeth whitening strips can be priced between the ranges of $30 – $45. For example Crest whitening strips contain 14 packs that could cost around $ 40; each pack has 2 strips for the upper and lower teeth.
How to use teeth whitening strips?
Using a teeth whitening strip is an easy process. The pair of strips is applied in such a way, one strip is applied on the upper teeth and the other one applied on the lower teeth. Ensure whether the gel side adheres on the teeth. Leave the teeth whitening strips for 30 minutes so let them do the magic on your teeth to make it dazzling.
Advantages of using whitening strips
You can scan huge number of teeth whitening products available in the market. How the teeth whitening strips shine one step ahead of the ordinary tooth whitening product? The answer is very simple and straight, you can use these strips anywhere you want. There are no constraints in using these strips while you take a walk to a beach, drive to your office, watching TV, taking shower or while you read your books.
Whitening strips are the most convenient choice for getting brighter teeth because of the assurance it provides us to give prominent results in maintaining our oral health. Since it can be used as one of the home based teeth whitening products, it is the most sort after dental care product of the moment.


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Meal replacement powders and weight gain shakes are NOT ideal for building healthy, lean muscles, although many of these products seem to do just enough to maintain muscle mass but not enough to add bulk to overall size. Weight Gain Stays Strong as Long as Diet Weight gain doesn't stop with diet, shakes can how with lose meal much replacement weight i. Studies from the US National Institutes of Health's Institute for Biomedical Research found that while weight gain continues after a certain threshold, it usually is only a matter of time until the body is so bloated it can no longer use that excess calories for energy so it will just go back to burning fat instead, anabolic steroids online shopping in india. The longer a diet is maintained, however, the greater the risk of having too much of your fat stored as stored body fat and it also comes to the part of your muscles and tendons that burn fuel and provide the bulk to build muscle. Weight gain comes from three main sources: Increased use of energy as fuel: Increased muscle mass and muscle efficiency in your muscles may not be the only reason for weight gain, anabolic steroids pct cycle. The more muscle mass you have, the higher your body's metabolic rate is that allows the body to generate more calories to fuel its daily life (the metabolic rate refers to your body's ability to use available energy). If your body's metabolic rate was slower, it could still pump out enough calories to be able to maintain muscle strength and muscle mass but not be able to store enough extra energy in fat deposits to compensate, anabolic steroids over 40. Increased fat loss; this type of weight retention is caused by the body using excess energy by burning the fat as fuel. You may not have a huge amount of muscle but if you can lose fat, you should be able to gain muscle again after weight loss or dieting. Decreased physical activity: For men who have had a low-quality diet, such as diets that were low in fats and high in alcohol, increased physical activity has been estimated to help lower their rates of obesity, diabetes, and heart disease, anabolic steroids online shopping in india. When You Gain Weight If it isn't due to diet or physical activity, the number of pounds you actually gain each month will be higher than your normal weight when you gain weight. When you stop gaining weight, it's best to start monitoring your caloric intake and how much it is that you are getting from food, which could be the difference between gaining a ton or not even being at all effective, how much weight can i lose with meal replacement shakes. Weight Gain Tips: Keep in mind that the following are important, but may not be required, if you're already losing body weight, anabolic steroids online shopping in india.
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Other Sellers on Amazon
Fiber One Cereal, Original Bran, Whole Grain, 16.2 oz, 6 Pack
Enhance your purchase
|Brand||General Mills Cereals|
About this item
- BRAN CEREAL: Delicious bran cereal that contains whole grains to help get your morning started.
- WHOLESOME INGREDIENTS: Made with 13 grams of whole grain per serving.
- FIBER SNACK: Each bar contains 55% Daily Value of Fiber. Diets high in fiber can help keep your digestive system on track, yet only 1 out of 10 Americans get enough.
- NUTRIENT-RICH: 60 calories per serving and packed with 10 vitamins and minerals.
- BOX CONTAINS: 1 box, 16.2 oz
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From the manufacturer
Fiber One Cereal
Delightfully simple, whole-grain taste, and so many different benefits!
- 55% daily value of Fiber
- 14g Fiber per serving
- 90 Calories per serving
Whole grain wheat, corn bran, modified wheat starch, guar gum, color (caramel color and annatto extract), cellulose gum, salt, baking soda, sucralose, natural flavor.
Fiber One Cereal is made with delicious flakes with honey clusters, brown sugar and toasted oats. All the flavors you love with the benefits of fiber!
- Is Discontinued By Manufacturer : No
- Package Dimensions : 14.4 x 14.2 x 8.9 inches; 1.01 Pounds
- Manufacturer : GENERAL MILLS SALES INC.
- ASIN : B078S8DDZH
- Best Sellers Rank: #7,481 in Grocery & Gourmet Food (See Top 100 in Grocery & Gourmet Food)
- #89 in Cold Breakfast Cereals
- Customer Reviews:
This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings
Whole Grain Wheat, Corn Bran, Modified Wheat Starch, Color (caramel color and annatto extract), Guar Gum, Cellulose Gum, Salt, Baking Soda, Sucralose, Natural Flavor. Vitamins and Minerals: Calcium Carbonate, Vitamin C (sodium ascorbate), Iron and Zinc (mineral nutrients), A B Vitamin (niacinamide), Vitamin B6 (pyridoxine hydrochloride), Vitamin B1 (thiamin mononitrate), Vitamin B2 (riboflavin), A B Vitamin (folic acid), Vitamin B12.
Ready to Eat
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
Reviewed in the United States on December 19, 2018
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Update: Not buying this again from Amazon. The seller increased the price so much that it's now cheaper to buy at the grocery store again. Greedy!
Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.


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The amazing healing powers of Hyaluronic Acid can’t be understated. There countless useful applications for this medicinal supplement. Whether it is used for help with osteoarthritis, speeding up the process of healing severe burns or give skin a firm, full boost, this amazing substance is worth its weight in gold!. Due to its meteoric rise in popularity, hundreds of the cheap low-quality brands have added it to their product line up. Don’t miss out on the full benefits of topical skin care magnificence by investing in watered down products. Keep reading and learn about the Hyaluronic Acid skin supplements that are shown to produce results! The best part is, all these products are organic, keeping your skin moist, beautiful, and natural.
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Sothy’s Hydra 3Ha Hyaluronic Acid Hydrating Gel-Cream
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AnneMarie Borlind Aqua Nature Hyaluronate Eye Cream
The budget-friendly option on our list still packs a major punch. The amazing benefits of hyaluronic acid supplements can be widespread or extremely targeted. This eye cream uses the power of HA to its maximum potential. For those of us over the age of 30 with declining levels and puffiness, this product is a must-have. With an unorthodox topical blend of Hyaluronic Acid and marine plant extracts, it’s sure to stimulate the ocular area in a way very few products do. Kiss lines and puffiness goodbye, while saying hello to the firm lively glow of organic caffeine. At $39.60 it is an eye treatment that can take any skincare routine up a notch in a healthy and affordable way.
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Looking for best blister prevention for shoes? Check these top products from boils and blister category.
Recommendation No. 1
Gold Bond Friction Defense Stick 1.75 oz., Soothes & Comforts for Daily Friction Prevention, Package may vary
- CONTAINS: One (1) 1.75-oz. stick of Gold Bond Friction Defense
- FRICTION DEFENSE: This stick reduces friction and comforts skin
- SOOTHES & COMFORTS: Gold Bond Friction Defense moisturizes and soothes skin
- GENTLE ON SENSITIVE SKIN: Gold Bond Friction Defense is non-greasy, unscented and gentle on skin
- EASY TO USE: Apply the formula liberally to the affected area as often as needed
Recommendation No. 2
BodyGlide Foot Anti Blister Balm, 0.80 oz (USA Sale Only)
- Apply before you put on shoes, to help prevent blisters and raw skin caused by rubbing
- Use daily for effective and long lasting protection of toes and feet, even in demanding conditions
- Infused with Vitamin A and C to help soften skin and restore dry, chapped, and chafed feet. Helps minimize inflammation
- Keeps pores clog free. Sweat escapes and lets skin breathe. Footwear safe
- Made with allergen free, plant-derived ingredients. Vegan approved, never tested on animals. Child safe
Recommendation No. 3
Dr.Scholl’s Plantar Fasciitis Pain Relief Orthotics Clinically Proven Relief and Prevention of Plantar Fasciitis Pain for, Standart, standard, Trim to Fit: Women's Size 6-10, standard, 1 Pair
- Designed for people who suffer pain from plantar fasciitis in the heel
- With shock guard technology to provide immediate and all-day relief of pain from plantar fasciitis and can help reduce morning pain from plantar fasciitis
- Full-length insole cushions and supports the entire foot
- Fits casual shoes, sneakers and work boots/shoes. Trim to fit shoe size
Recommendation No. 4
Dr. Scholl’s Moleskin Plus Padding Roll (24" x 4 5/8") / All-Day Pain Relief and Protection from Shoe Friction with Soft Padding That Conforms to the Foot and Can Be Cut To Any Size
- Thin design conforms to the foot and fits in all shoes
- Designed to stay on all day
- Cuttable Moleskin can be shaped to any size
Recommendation No. 5
Band-Aid Brand Hydro Seal Adhesive Bandages for Heel Blisters, Waterproof Blister Pad & Hydrocolloid Gel Bandage, Sterile & Long-Lasting, 6 ct
- Band-Aid Brand Sterile Hydro Seal Waterproof Adhesive Hydrocolloid Gel Bandages for Heel Blisters, Cushioning, Waterproof & Shower Proof Blister Pad for Blister Relief, Long Lasting, 6 ct
- These waterproof blister pads provide an optimal healing environment for blisters and wounds, sealing out dirt, germs, and water and helping prevent formation of scabs, which prolong healing and can cause scarring
- The unique hydrocolloid gel material of this adhesive bandage is designed for long term wear, staying on for multiple days and through showers, and intended to be worn until they begin to detach
- Sterile hydrocolloid gel blister bandage provides the optimal wound healing environment, and is designed to provide cushioning against painful blisters or wounds on heels and shields from further rubbing to prevent re-injury
- From the #1 doctor recommended bandage brand, Hydro Seal Blister Bandages for Heels are sterile and not made with natural rubber latex. First-aid bandage prevents wound from drying out with its dual action seal, sealing out dirt, germs, and water
Recommendation No. 6
MATIE FIX Heel Grips Liner Cushions Inserts for Loose Shoes, Heel Pads Snugs for Shoe Too Big Men Women, Filler Improved Shoe Fit and Comfort, Prevent Heel Slip and Blister (4 Pairs )
- Package Includes: 4 pair *Heel Liners（2 pairs Pale Apricot+2 pairs black）
- Material: Made of Suede materials ,ensure breathable, comfort and cushionin
- Easy to use: these shoe heel stickers have self-adhesive backs; Peeling off the back cover, you can stick them on your shoes backs conveniently
- Wide application: these heel cushion pads fit for many shoes such as high-heels, leather shoes; They are applicable to new shoes and slightly bigger shoes, suitable for all people
- Worry-free products and services: no reason to refund within 30 days.If you have any problem in use, please contact us through Amazon email. Our customer service staff will certainly give you a satisfactory solution. Moreover, we do not want your used products to be returned to Amazon warehouse and sold to other customers
Recommendation No. 7
Dr. Frederick's Original Better Blister Bandages - 12 ct Variety - Waterproof Hydrocolloid Bandages for Foot, Toe, & Heel Blister Prevention & Recovery - Blister Pads
- TREAT & PREVENT BLISTERS: Our large assorted pack of bandage patches is perfect for any active person. Like moleskin for feet protection, our bandage kit protects and prevents any blister. But our blister gel guard bandages do something extra: they treat the blister while you wear it.
- WATERPROOF PROTECTION: Once you apply a heel or toe bandage from our variety pack, the blister is protected from water, germs, sweat, and additional friction, even during the sweatiest hike or dance class.
- ULTRA-STICKY: Our customers have the best results applying the hydrocolloid bandage patches to clean, dry skin. The toe bandages are very sticky, and stay where you want them until they're done absorbing moisture from the blister.
- PERFECT FOR DAILY WEAR: Use these blister pad bandages as heel blister protectors. To mitigate blisters in business meetings or on the golf course, apply our blister kit to hot spots before you leave the house. Blisters are prevented before they can start!
- GET BACK TO IT GUARANTEE: Your results are our top priority. It's part of who we are as physicians. So if your flexible blister pads purchase doesn't help you get back to doing what you love, we'll find something that will or we'll give you your money back. That's our promise to help you Get Back to the Original You.
Recommendation No. 8
Tea Tree Oil Wonder Balm by Puriya, Use with Jock Itch, Athletes Foot, Body Acne, Back Acne Cleansers, Fast Acting Comfort Cream for Dry, Itchy Skin, Plant Powered, Extra Strength, Physician Approved
- Tried And True Formula: Our effective, fast acting tea tree oil balm received the “Family Tested Family Approved” seal for its gentle yet powerful and fast acting relief for skin conditions developed in warm, moist, sweaty environments. Wonder Balm is a proven formula you can trust
- Forms Defense Layer On Skin: Our extra strength cream is powerful to provide fast relief for itchy and irritated skin and is gentle enough to use all over the body daily to form a skin defense layer, including on sensitive areas where moisture and sweat get trapped, such as the groin and between toes
- Extra Strength, Plant Rich Ingredients: Potent doses of tea tree essential oil and eucalyptus essential oil soothe itchy burning skin, nourishing macadamia oil relieves dryness and discomfort. Olive oil quickly penetrates and is absorbed by the skin barrier to work fast for your comfort. No preservatives, parabens, or petroleum, only safe and clean ingredients
- Stay Put Formulation Safeguards Skin For Active Lifestyles: Puriya Wonder Balm is uniquely formulated with beeswax that shields skin from irritants (ones that cause itchy feet, groin discomfort, and ring-shaped rashes) lurking in moist areas, such as gyms, showers, saunas, locker rooms, and swimming pools. Wonder Balm forms a barrier between surfaces and your skin no matter how active you are or how humid the environment
- Sweatproof, Lightweight, Non Greasy Skin Ointment: Puriya Wonder Balm is a sweatproof formula that works around the clock to provide a natural barrier. Apply to feet, between toes, groin, and sensitive, intimate areas for continual relief that isn’t heavy and won’t clog pores. Wonder Balm ensures your skin smells clean, use it daily to avoid embarrassing foot odor
Recommendation No. 9
ZenToes Metatarsal Pads for Women and Men - 4 Pack Ball of Foot Cushions (Beige)
- Unisex Fit - This 4-pack of gel metatarsalgia dancer pads fit men’s size 6-9 and women’s 8-11 to offer more comfort, support and reliability across the entire forefoot. Unlike a shoe insole, our meta pads are designed to be worn over your foot for better fit and protection to the bottom of your feet.
- Reduce Friction & Discomfort - Alleviate pain due to calluses, bunions, corns, sesamoiditis or Morton neuromas caused by long periods of standing, running, dancing, or other high impact activities. The cushioning gel comforts, soothes and balances your forefeet for all day relief, whether wearing high heels, running shoes or loafers.
- 4 Pack of Comforting Foot Supports - Relieves pressure on the ball of your foot by providing weight distribution and shock absorption while walking, running and standing. Protects the fragile sesamoid and metatarsals from further damage.
- Best Value - ZenToes Metatarsal Ball of Foot cushions save you money because they are washable and reusable. Simply hand wash with gentle soap and warm water and lay flat to dry. With 4 pads in each package, you’ll always have a pair ready to wear!
- 100% Satisfaction Guaranteed - ZenToes is dedicated to providing the best foot care aids possible. Our foot care products are made with medical grade materials and prepared for shipment in the United States for quality and durability you can trust every day.
Recommendation No. 10
BSN Medical BEI076168 Leukotape P Sports Tape, 1 1/2 Inch x 15 Yard
- Leukotape P is specifically designed for the patellofemoral (McConnell) taping
- High tensile strength yet hand tearable for easy application
- Rigid joint immobilization and limitation of movement
- Protects skin from scratches and rubbing
Last update on 2022-06-28 / Affiliate links / Images from Amazon Product Advertising API


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If you’ve been in search of an CBD supplement that will help you relax your mind, full spectrum CBD oil might be the way to go. >>> Buy Full Spectrum CBD In Tyler, TX? CLICK HERE To Buy CBD Full Spectrum Online With Our Discount Code And Save More, Or Read On >>> The Full Spectrum CBD oil contains a mix of cannabinoids in varying levels. Unlike CBD isolate which is a single component of the CBD complex it includes all the different cannabinoids in hemp.
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- IRI Pacesetter report shows strength in beauty, consumables
- SymphonyIRI Group rebrands as IRi, commits to supporting CPG growth around the globe
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As expected, sales of sun care products experienced a boost in the most recent 12 weeks, according to SymphonyIRI Group, and it is likely that a greater consumer awareness of the dangers of the sun’s harmful rays and product innovation helped fuel growth.
Energizer Personal Care now has established a sun care division and recently launched its Everyday Essentials Platform, which will aim to change the way people think about and shop for sun care products. By 2020, EPC’s sun care division wants 1-in-2 people across North America to recognize sunscreen as an everyday essential.
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The researchers developed a method for the quantitation of four bioactive forms of vitamin B12 (adenosylcobalamin, cyanocobalamin, hydroxocobalamin, methylcobalamin, collectively known as cobalamins) from dietary ingredients and supplements.
The method, outlined in a paper recently published in Food Chemistry, is called High Performance Liquid Chromatography Diode-Array Detection (or HPLC-DAD), developed and validated to provide an easy-to-implement quality control solution for the dietary supplement industry.
According to the Standard Methods Performance Requirements set by the AOAC, an independent nonprofit association that develops standards on a voluntary consensus founded in 1884, all four cobalamins should be determined individually.
Previously used methods compliant to these standards, however, have some pitfalls.
The AOAC official method is efficient in determining total vitamin B12 using common ultraviolet instrumentation, but the method converts all forms of vitamin B12 into cyanocobalamin and therefore does not distinguish the source of them.
Moreover, most of recent published vitamin B12 analytical methods use high-expense instruments such as mass spectrometry, the researchers argued.
Eurofins' director of research and development, Dr Hong You, led the project and was principal investigator.
More vitamin B12 on the market
Growing demand for vitamin B12 products motivated the need to develop an accurate, efficient, and cost-effective method of quantifying it.
“Theoretically, vitamin B12 deficiency is rare in normal healthy population, but vegans or vegetarians, pregnant women, infants, and eating disorder patients can be vulnerable to vitamin B12 deficiency because of their special dietary customs requirements and physiological needs,” the authors wrote.
With the rise of the brain health category in dietary supplements and functional food and beverage, product formulators are increasingly adding vitamin B12 into products, which has been linked to cognitive benefits.
The researchers purchased supplements on iherb.com for testing.
The contents of dietary supplements were combined prior to sample extraction to ensure homogeneity. For tablets, 20 tablets were ground in a coffee grinder and mixed thoroughly. For capsules, the contents of 20 capsules were combined and ground by mortar and pestle thoroughly. For powders, 10 serving size were combined and ground by mortar and pestle thoroughly. Due to the light sensitivity of vitamin B12 cobalamins, all the sample preparation were conducted in the dark room and/or under UV blocking fluorescent light
To demonstrate the method’s selectivity, an excipient blend (considered as the “Placebo” of tablet, capsule, and powder dietary supplements) expected to be free of active vitamin B12 was tested to evaluate potential chromatographic interferences from the typical filler ingredients used in tablet, capsule, and powder dietary supplements.
“This method is relatively simple (no extensive sample prep; straightforward HPLC method with a single column), quite fast, can distinguish four forms of bioactive vitamin B12, and do so with DAD detection,” the researchers reported.
“Being simple and fast also translates into lower cost.”
Source: Food Chemistry
Published online ahead of print, https://doi.org/10.1016/j.foodchem.2019.125010
“Determination of active vitamin B12 (cobalamin) in dietary supplements and ingredients by reversed-phase liquid chromatography: Single-laboratory validation”
Authors: Xiao Qiu, et al.


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