A genomic change on Chromosome 3 affects LOC107303340, VHL (3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region| von Hippel-Lindau tumor suppressor). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Hereditary cancer-predisposing syndrome