The following genetic variant occurs in LOC107303340, VHL (3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region| von Hippel-Lindau tumor suppressor) on Chromosome 3. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Hereditary cancer-predisposing syndrome