With a mutation on Chromosome 15 in gene FBN1, LOC126862124 (fibrillin 1| CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:48764566-48765765), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Familial thoracic aortic aneurysm and aortic dissection