Chromosome 3 houses a mutation in gene LOC107303340, VHL (3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region| von Hippel-Lindau tumor suppressor). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Von Hippel-Lindau syndrome