A variant has been detected on Chromosome 3 in LOC107303340, VHL (3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region| von Hippel-Lindau tumor suppressor). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Hereditary cancer-predisposing syndrome