Chromosome 16 houses a mutation in gene LOC126862264, MEFV (CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:3293322-3294521| MEFV innate immunity regulator, pyrin). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Familial Mediterranean fever, autosomal dominant