A variant was discovered on Chromosome 3, affecting LOC107303340, VHL (3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region| von Hippel-Lindau tumor suppressor). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Hereditary cancer-predisposing syndrome