Chromosome 14 houses a mutation in gene LOC126862021, CALM1 (CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:90870785-90871984| calmodulin 1). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Catecholaminergic polymorphic ventricular tachycardia 4