Chromosome 2 houses a mutation in gene UGT1A, UGT1A5, UGT1A7, UGT1A8, UGT1A9, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6 (UDP glucuronosyltransferase family 1 member A complex locus| UDP glucuronosyltransferase family 1 member A5| UDP glucuronosyltransferase family 1 member A7| UDP glucuronosyltransferase family 1 member A8| UDP glucuronosyltransferase family 1 member A9| UDP glucuronosyltransferase family 1 member A1| UDP glucuronosyltransferase family 1 member A10| UDP glucuronosyltransferase family 1 member A3| UDP glucuronosyltransferase family 1 member A4| UDP glucuronosyltransferase family 1 member A6). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Crigler-Najjar syndrome