A variant found in Chromosome 3 affects LOC107303340, VHL (3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region| von Hippel-Lindau tumor suppressor). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Chuvash polycythemia