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homo_sapiens_unfiltered_Diff

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accession
stringlengths
6
10
sequence
stringlengths
6
103k
function
stringlengths
15
5.47k
P52952
<M><F><P><S><P><A><L><T><P><T><P><F><S><V><K><D><I><L><N><L><E><Q><Q><Q><R><S><L><A><A><A><G><E><L><S><A><R><L><E><A><T><L><A><P><S><S><C><M><L><A><A><F><K><P><E><A><Y><A><G><P><E><A><A><A><P><G><L><P><E><L><R><A><E><L><G><R><A><P><S><P><A><K><C><A><S><A><F><P><A><A><P><A><F><Y><P><R><A><Y><S><D><P><D><P><A><K><D><P><R><A><E><K><K><E><L><C><A><L><Q><K><A><V><E><L><E><K><T><E><A><D><N><A><E><R><P><R><A><R><R><R><R><K><P><R><V><L><F><S><Q><A><Q><V><Y><E><L><E><R><R><F><K><Q><Q><R><Y><L><S><A><P><E><R><D><Q><L><A><S><V><L><K><L><T><S><T><Q><V><K><I><W><F><Q><N><R><R><Y><K><C><K><R><Q><R><Q><D><Q><T><L><E><L><V><G><L><P><P><P><P><P><P><P><A><R><R><I><A><V><P><V><L><V><R><D><G><K><P><C><L><G><D><S><A><P><Y><A><P><A><Y><G><V><G><L><N><P><Y><G><Y><N><A><Y><P><A><Y><P><G><Y><G><G><A><A><C><S><P><G><Y><S><C><T><A><A><Y><P><A><G><P><S><P><A><Q><P><A><T><A><A><A><N><N><N><F><V><N><F><G><V><G><D><L><N><A><V><Q><S><P><G><I><P><Q><S><N><S><G><V><S><T><L><H><G><I><R><A><W>
Transcription factor required for the development of the heart and the spleen. May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal. Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression. Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia.<BOP>
Q969K3
<M><K><A><G><A><T><S><M><W><A><S><C><C><G><L><L><N><E><V><M><G><T><G><A><V><R><G><Q><Q><S><A><F><A><G><A><T><G><P><F><R><F><T><P><N><P><E><F><S><T><Y><P><P><A><A><T><E><G><P><N><I><V><C><K><A><C><G><L><S><F><S><V><F><R><K><K><H><V><C><C><D><C><K><K><D><F><C><S><V><C><S><V><L><Q><E><N><L><R><R><C><S><T><C><H><L><L><Q><E><T><A><F><Q><R><P><Q><L><M><R><L><K><V><K><D><L><R><Q><Y><L><I><L><R><N><I><P><I><D><T><C><R><E><K><E><D><L><V><D><L><V><L><C><H><H><G><L><G><S><E><D><D><M><D><T><S><S><L><N><S><S><R><S><Q><T><S><S><F><F><T><R><S><F><F><S><N><Y><T><A><P><S><A><T><M><S><S><F><Q><G><E><L><M><D><G><D><Q><T><S><R><S><G><V><P><A><Q><V><Q><S><E><I><T><S><A><N><T><E><D><D><D><D><D><D><D><E><D><D><D><D><E><E><E><N><A><E><D><R><N><P><G><L><S><K><E><R><V><R><A><S><L><S><D><L><S><S><L><D><D><V><E><G><M><S><V><R><Q><L><K><E><I><L><A><R><N><F><V><N><Y><S><G><C><C><E><K><W><E><L><V><E><K><V><N><R><L><Y><K><E><N><E><E><N><Q><K><S><Y><G><E><R><L><Q><L><Q><D><E><E><D><D><S><L><C><R><I><C><M><D><A><V><I><D><C><V><L><L><E><C><G><H><M><V><T><C><T><K><C><G><K><R><M><S><E><C><P><I><C><R><Q><Y><V><V><R><A><V><H><V><F><K><S>
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells. Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.<BOP>
P33992
<M><S><G><F><D><D><P><G><I><F><Y><S><D><S><F><G><G><D><A><Q><A><D><E><G><Q><A><R><K><S><Q><L><Q><R><R><F><K><E><F><L><R><Q><Y><R><V><G><T><D><R><T><G><F><T><F><K><Y><R><D><E><L><K><R><H><Y><N><L><G><E><Y><W><I><E><V><E><M><E><D><L><A><S><F><D><E><D><L><A><D><Y><L><Y><K><Q><P><A><E><H><L><Q><L><L><E><E><A><A><K><E><V><A><D><E><V><T><R><P><R><P><S><G><E><E><V><L><Q><D><I><Q><V><M><L><K><S><D><A><S><P><S><S><I><R><S><L><K><S><D><M><M><S><H><L><V><K><I><P><G><I><I><I><A><A><S><A><V><R><A><K><A><T><R><I><S><I><Q><C><R><S><C><R><N><T><L><T><N><I><A><M><R><P><G><L><E><G><Y><A><L><P><R><K><C><N><T><D><Q><A><G><R><P><K><C><P><L><D><P><Y><F><I><M><P><D><K><C><K><C><V><D><F><Q><T><L><K><L><Q><E><L><P><D><A><V><P><H><G><E><M><P><R><H><M><Q><L><Y><C><D><R><Y><L><C><D><K><V><V><P><G><N><R><V><T><I><M><G><I><Y><S><I><K><K><F><G><L><T><T><S><R><G><R><D><R><V><G><V><G><I><R><S><S><Y><I><R><V><L><G><I><Q><V><D><T><D><G><S><G><R><S><F><A><G><A><V><S><P><Q><E><E><E><E><F><R><R><L><A><A><L><P><N><V><Y><E><V><I><S><K><S><I><A><P><S><I><F><G><G><T><D><M><K><K><A><I><A><C><L><L><F><G><G><S><R><K><R><L><P><D><G><L><T><R><R><G><D><I><N><L><L><M><L><G><D><P><G><T><A><K><S><Q><L><L><K><F><V><E><K><C><S><P><I><G><V><Y><T><S><G><K><G><S><S><A><A><G><L><T><A><S><V><M><R><D><P><S><S><R><N><F><I><M><E><G><G><A><M><V><L><A><D><G><G><V><V><C><I><D><E><F><D><K><M><R><E><D><D><R><V><A><I><H><E><A><M><E><Q><Q><T><I><S><I><A><K><A><G><I><T><T><T><L><N><S><R><C><S><V><L><A><A><A><N><S><V><F><G><R><W><D><E><T><K><G><E><D><N><I><D><F><M><P><T><I><L><S><R><F><D><M><I><F><I><V><K><D><E><H><N><E><E><R><D><V><M><L><A><K><H><V><I><T><L><H><V><S><A><L><T><Q><T><Q><A><V><E><G><E><I><D><L><A><K><L><K><K><F><I><A><Y><C><R><V><K><C><G><P><R><L><S><A><E><A><A><E><K><L><K><N><R><Y><I><I><M><R><S><G><A><R><Q><H><E><R><D><S><D><R><R><S><S><I><P><I><T><V><R><Q><L><E><A><I><V><R><I><A><E><A><L><S><K><M><K><L><Q><P><F><A><T><E><A><D><V><E><E><A><L><R><L><F><Q><V><S><T><L><D><A><A><L><S><G><T><L><S><G><V><E><G><F><T><S><Q><E><D><Q><E><M><L><S><R><I><E><K><Q><L><K><R><R><F><A><I><G><S><Q><V><S><E><H><S><I><I><K><D><F><T><K><Q><K><Y><P><E><H><A><I><H><K><V><L><Q><L><M><L><R><R><G><E><I><Q><H><R><M><Q><R><K><V><L><Y><R><L><K>
Acts as a component of the MCM2-7 complex. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<BOP>
A6NM03
<M><E><L><R><N><S><T><L><G><S><G><F><I><L><V><G><I><L><N><D><S><G><S><P><E><L><L><Y><A><T><F><T><I><L><Y><M><L><A><L><T><S><N><G><L><L><L><L><A><I><T><I><E><A><R><L><H><M><P><M><Y><L><L><L><G><Q><L><S><L><M><D><L><L><F><T><S><V><V><T><P><K><A><L><A><D><F><L><R><R><E><N><T><I><S><F><G><G><C><A><L><Q><M><F><L><A><L><T><M><G><S><A><E><D><L><L><L><A><F><M><A><Y><D><R><Y><V><A><I><C><H><P><L><K><Y><M><T><L><M><S><P><R><V><C><W><I><M><V><A><T><S><W><I><L><A><S><L><I><A><I><G><H><T><M><Y><T><M><H><L><P><F><C><V><S><W><E><I><R><H><L><L><C><E><I><P><P><L><L><K><L><A><C><A><D><T><S><R><Y><E><L><I><I><Y><V><T><G><V><T><F><L><L><L><P><I><S><A><I><V><A><S><Y><T><L><V><L><F><T><V><L><R><M><P><S><N><E><G><R><K><K><A><L><V><T><C><S><S><H><L><I><V><V><G><M><F><Y><G><A><A><T><F><M><Y><V><L><P><S><S><F><H><S><P><K><Q><D><N><I><I><S><V><F><Y><T><I><V><T><P><A><L><N><P><L><I><Y><S><L><R><N><K><E><V><M><R><A><L><R><R><V><L><G><K><Y><I><L><L><A><H><S><T><L>
Odorant receptor.<BOP>
P07451
<M><A><K><E><W><G><Y><A><S><H><N><G><P><D><H><W><H><E><L><F><P><N><A><K><G><E><N><Q><S><P><V><E><L><H><T><K><D><I><R><H><D><P><S><L><Q><P><W><S><V><S><Y><D><G><G><S><A><K><T><I><L><N><N><G><K><T><C><R><V><V><F><D><D><T><Y><D><R><S><M><L><R><G><G><P><L><P><G><P><Y><R><L><R><Q><F><H><L><H><W><G><S><S><D><D><H><G><S><E><H><T><V><D><G><V><K><Y><A><A><E><L><H><L><V><H><W><N><P><K><Y><N><T><F><K><E><A><L><K><Q><R><D><G><I><A><V><I><G><I><F><L><K><I><G><H><E><N><G><E><F><Q><I><F><L><D><A><L><D><K><I><K><T><K><G><K><E><A><P><F><T><K><F><D><P><S><C><L><F><P><A><C><R><D><Y><W><T><Y><Q><G><S><F><T><T><P><P><C><E><E><C><I><V><W><L><L><L><K><E><P><M><T><V><S><S><D><Q><M><A><K><L><R><S><L><L><S><S><A><E><N><E><P><P><V><P><L><V><S><N><W><R><P><P><Q><P><I><N><N><R><V><V><R><A><S><F><K>
Reversible hydration of carbon dioxide.<BOP>
Q92637
<M><W><F><L><T><T><L><L><L><W><V><P><V><D><G><Q><V><D><T><T><K><A><V><I><T><L><Q><P><P><W><V><S><V><F><Q><E><E><T><V><T><L><H><C><E><V><L><H><L><P><G><S><S><S><T><Q><W><F><L><N><G><T><A><T><Q><T><S><T><P><S><Y><R><I><T><S><A><S><V><N><D><S><G><E><Y><R><C><Q><R><G><L><S><G><R><S><D><P><I><Q><L><E><I><H><R><G><W><L><L><L><Q><V><S><S><R><V><F><M><E><G><E><P><L><A><L><R><C><H><A><W><K><D><K><L><V><Y><N><V><L><Y><Y><R><N><G><K><A><F><K><F><F><H><W><N><S><N><L><T><I><L><K><T><N><I><S><H><N><G><T><Y><H><C><S><G><M><G><K><H><R><Y><T><S><A><G><I><S><Q><Y><T><V><K><G><L><Q><L><P><T><P><V><W><F><H><V><L><F><Y><L><A><V><G><I><M><F><L><V><N><T><V><L><W><V><T><I><R><K><E><L><K><R><K><K><K><W><N><L><E><I><S><L><D><S><G><H><E><K><K><V><I><S><S><L><Q><E><D><R><H><L><E><E><E><L><K><C><Q><E><Q><K><E><E><Q><L><Q><E><G><V><H><R><K><E><P><Q><G><A><T>
May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.<BOP>
O15446
<M><E><E><P><Q><A><G><D><A><A><R><F><S><C><P><P><N><F><T><A><K><P><P><A><S><E><S><P><R><F><S><L><E><A><L><T><G><P><D><T><E><L><W><L><I><Q><A><P><A><D><F><A><P><E><C><F><N><G><R><H><V><P><L><S><G><S><Q><I><V><K><G><K><L><A><G><K><R><H><R><Y><R><V><L><S><S><C><P><Q><A><G><E><A><T><L><L><A><P><S><T><E><A><G><G><G><L><T><C><A><S><A><P><Q><G><T><L><R><I><L><E><G><P><Q><Q><S><L><S><G><S><P><L><Q><P><I><P><A><S><P><P><P><Q><I><P><P><G><L><R><P><R><F><C><A><F><G><G><N><P><P><V><T><G><P><R><S><A><L><A><P><N><L><L><T><S><G><K><K><K><K><E><M><Q><V><T><E><A><P><V><T><Q><E><A><V><N><G><H><G><A><L><E><V><D><M><A><L><G><S><P><E><M><D><V><R><K><K><K><K><K><K><N><Q><Q><L><K><E><P><E><A><A><G><P><V><G><T><E><P><T><V><E><T><L><E><P><L><G><V><L><F><P><S><T><T><K><K><R><K><K><P><K><G><K><E><T><F><E><P><E><D><K><T><V><K><Q><E><Q><I><N><T><E><P><L><E><D><T><V><L><S><P><T><K><K><R><K><R><Q><K><G><T><E><G><M><E><P><E><E><G><V><T><V><E><S><Q><P><Q><V><K><V><E><P><L><E><E><A><I><P><L><P><P><T><K><K><R><K><K><E><K><G><Q><M><A><M><M><E><P><G><T><E><A><M><E><P><V><E><P><E><M><K><P><L><E><S><P><G><G><T><M><A><P><Q><Q><P><E><G><A><K><P><Q><A><Q><A><A><L><A><A><P><K><K><K><T><K><K><E><K><Q><Q><D><A><T><V><E><P><E><T><E><V><V><G><P><E><L><P><D><D><L><E><P><Q><A><A><P><T><S><T><K><K><K><K><K><K><K><E><R><G><H><T><V><T><E><P><I><Q><P><L><E><P><E><L><P><G><E><G><Q><P><E><A><R><A><T><P><G><S><T><K><K><R><K><K><Q><S><Q><E><S><R><M><P><E><T><V><P><Q><E><E><M><P><G><P><P><L><N><S><E><S><G><E><E><A><P><T><G><R><D><K><K><R><K><Q><Q><Q><Q><Q><P><V>
Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Involved in UBTF-activated transcription, presumably at a step following PIC formation. Has been described as a component of preformed T-cell receptor (TCR) complex.<BOP>
P30876
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Catalytic core component of RNA polymerase II. RNA-dependent RNA polymerase that catalyzes the extension of a non-coding RNA (ncRNA) at the 3'-end using the four ribonucleoside triphosphates as substrates. An internal ncRNA sequence near the 3'-end serves as a template in a single-round Pol II-mediated RNA polymerization reaction. May decrease the stability of ncRNAs that repress Pol II-mediated gene transcription.<BOP>
Q13224
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Component of N-methyl-D-aspartate. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.<BOP>
Q9Y4E5
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E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.<BOP>
Q5BKX6
<M><K><M><A><P><Q><N><A><D><P><E><S><M><Q><V><Q><E><L><S><V><P><L><P><D><P><Q><K><A><G><G><A><E><A><E><N><C><E><T><I><S><E><G><S><I><D><R><I><P><M><R><L><W><V><M><H><G><A><V><M><F><G><R><E><F><C><Y><A><M><E><T><A><L><V><T><P><I><L><L><Q><I><G><L><P><E><Q><Y><Y><S><L><T><W><F><L><S><P><I><L><G><L><I><F><T><P><L><I><G><S><A><S><D><R><C><T><L><S><W><G><R><R><R><P><F><I><L><A><L><C><V><G><V><L><F><G><V><A><L><F><L><N><G><S><A><I><G><L><A><L><G><D><V><P><N><R><Q><P><I><G><I><V><L><T><V><L><G><V><V><V><L><D><F><S><A><D><A><T><E><G><P><I><R><A><Y><L><L><D><V><V><D><S><E><E><Q><D><M><A><L><N><I><H><A><F><S><A><G><L><G><G><A><I><G><Y><V><L><G><G><L><D><W><T><Q><T><F><L><G><S><W><F><R><T><Q><N><Q><V><L><F><F><F><A><A><I><I><F><T><V><S><V><A><L><H><L><F><S><I><D><E><E><Q><Y><S><P><Q><Q><E><R><S><A><E><E><P><G><A><L><D><G><G><E><P><H><G><V><P><A><F><P><D><E><V><Q><S><E><H><E><L><A><L><D><Y><P><D><V><D><I><M><R><S><K><S><D><S><A><L><H><V><P><D><T><A><L><D><L><E><P><E><L><L><F><L><H><D><I><E><P><S><I><F><H><D><A><S><Y><P><A><T><P><R><S><T><S><Q><E><L><A><K><T><K><L><P><R><L><A><T><F><L><K><E><A><A><K><E><D><E><T><L><L><D><N><H><L><N><E><A><K><V><P><N><G><S><G><S><P><T><K><D><A><L><G><G><Y><T><R><V><D><T><K><P><S><A><T><S><S><S><M><R><R><R><R><H><A><F><R><R><Q><A><S><S><T><F><S><Y><Y><G><K><L><G><S><H><C><Y><R><Y><R><R><A><N><A><V><V><L><I><K><P><S><R><S><M><S><D><L><Y><D><M><Q><K><R><Q><R><Q><H><R><H><R><N><Q><S><G><A><T><T><S><S><G><D><T><E><S><E><E><G><E><G><E><T><T><V><R><L><L><W><L><S><M><L><K><M><P><R><E><L><M><R><L><C><L><C><H><L><L><T><W><F><S><V><I><A><E><A><V><F><Y><T><D><F><M><G><Q><V><I><F><E><G><D><P><K><A><P><S><N><S><T><A><W><Q><A><Y><N><A><G><V><K><M><G><C><W><G><L><V><I><Y><A><A><T><G><A><I><C><S><A><L><L><Q><K><Y><L><D><N><Y><D><L><S><V><R><V><I><Y><V><L><G><T><L><G><F><S><V><G><T><A><V><M><A><M><F><P><N><V><Y><V><A><M><V><T><I><S><T><M><G><I><V><S><M><S><I><S><Y><C><P><Y><A><L><L><G><Q><Y><H><D><I><K><Q><Y><I><H><H><S><P><G><N><S><K><R><G><F><G><I><D><C><A><I><L><S><C><Q><V><Y><I><S><Q><I><L><V><A><S><A><L><G><G><V><V><D><A><V><G><T><V><R><V><I><P><M><V><A><S><V><G><S><F><L><G><F><L><T><A><T><F><L><V><I><Y><P><N><V><S><E><E><A><K><E><E><Q><K><G><L><S><S><P><L><A><G><E><G><R><A><G><G><N><S><E><K><P><T><V><L><K><L><T><R><K><E><G><L><Q><G><P><V><E><T><E><S><V><V>
Proton-associated sucrose transporter. May be able to transport also glucose and fructose.<BOP>
Q8NH93
<M><G><M><S><N><L><T><R><L><S><E><F><I><L><L><G><L><S><S><R><S><E><D><Q><R><P><L><F><A><L><F><L><I><I><Y><L><V><T><L><M><G><N><L><L><I><I><L><A><I><H><S><D><P><R><L><Q><N><P><M><Y><F><F><L><S><I><L><S><F><A><D><I><C><Y><T><T><V><I><V><P><K><M><L><V><N><F><L><S><E><K><K><T><I><S><Y><A><E><C><L><A><Q><M><Y><F><F><L><V><F><G><N><I><D><S><Y><L><L><A><A><M><A><I><N><R><C><V><A><I><C><N><P><F><H><Y><V><T><V><M><N><R><R><C><C><V><L><L><L><A><F><P><I><T><F><S><Y><F><H><S><L><L><H><V><L><L><V><N><R><L><T><F><C><T><S><N><V><I><H><H><F><F><C><D><V><N><P><V><L><K><L><S><C><S><S><T><F><V><N><E><I><V><A><M><T><E><G><L><A><S><V><M><A><P><F><V><C><I><I><I><S><Y><L><R><I><L><I><A><V><L><K><I><P><S><A><A><G><K><H><K><A><F><S><T><C><S><S><H><L><T><V><V><I><L><F><Y><G><S><I><S><Y><V><Y><L><Q><P><L><S><S><Y><T><V><K><D><R><I><A><T><I><N><Y><T><V><L><T><S><V><L><N><P><F><I><Y><S><L><R><N><K><D><M><K><R><G><L><Q><K><L><I><N><K><I><K><S><Q><M><S><R><F><S><T><K><T><N><K><I><C><G><P>
Odorant receptor.<BOP>
Q9BZX2
<M><A><G><D><S><E><Q><T><L><Q><N><H><Q><Q><P><N><G><G><E><P><F><L><I><G><V><S><G><G><T><A><S><G><K><S><S><V><C><A><K><I><V><Q><L><L><G><Q><N><E><V><D><Y><R><Q><K><Q><V><V><I><L><S><Q><D><S><F><Y><R><V><L><T><S><E><Q><K><A><K><A><L><K><G><Q><F><N><F><D><H><P><D><A><F><D><N><E><L><I><L><K><T><L><K><E><I><T><E><G><K><T><V><Q><I><P><V><Y><D><F><V><S><H><S><R><K><E><E><T><V><T><V><Y><P><A><D><V><V><L><F><E><G><I><L><A><F><Y><S><Q><E><V><R><D><L><F><Q><M><K><L><F><V><D><T><D><A><D><T><R><L><S><R><R><V><L><R><D><I><S><E><R><G><R><D><L><E><Q><I><L><S><Q><Y><I><T><F><V><K><P><A><F><E><E><F><C><L><P><T><K><K><Y><A><D><V><I><I><P><R><G><A><D><N><L><V><A><I><N><L><I><V><Q><H><I><Q><D><I><L><N><G><G><P><S><K><R><Q><T><N><G><C><L><N><G><Y><T><P><S><R><K><R><Q><A><S><E><S><S><S><R><P><H>
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.<BOP>
O60315
<M><K><Q><P><I><M><A><D><G><P><R><C><K><R><R><K><Q><A><N><P><R><R><K><N><V><V><N><Y><D><N><V><V><D><T><G><S><E><T><D><E><E><D><K><L><H><I><A><E><D><D><G><I><A><N><P><L><D><Q><E><T><S><P><A><S><V><P><N><H><E><S><S><P><H><V><S><Q><A><L><L><P><R><E><E><E><E><D><E><I><R><E><G><G><V><E><H><P><W><H><N><N><E><I><L><Q><A><S><V><D><G><P><E><E><M><K><E><D><Y><D><T><M><G><P><E><A><T><I><Q><T><A><I><N><N><G><T><V><K><N><A><N><C><T><S><D><F><E><E><Y><F><A><K><R><K><L><E><E><R><D><G><H><A><V><S><I><E><E><Y><L><Q><R><S><D><T><A><I><I><Y><P><E><A><P><E><E><L><S><R><L><G><T><P><E><A><N><G><Q><E><E><N><D><L><P><P><G><T><P><D><A><F><A><Q><L><L><T><C><P><Y><C><D><R><G><Y><K><R><L><T><S><L><K><E><H><I><K><Y><R><H><E><K><N><E><E><N><F><S><C><P><L><C><S><Y><T><F><A><Y><R><T><Q><L><E><R><H><M><V><T><H><K><P><G><T><D><Q><H><Q><M><L><T><Q><G><A><G><N><R><K><F><K><C><T><E><C><G><K><A><F><K><Y><K><H><H><L><K><E><H><L><R><I><H><S><G><E><K><P><Y><E><C><P><N><C><K><K><R><F><S><H><S><G><S><Y><S><S><H><I><S><S><K><K><C><I><G><L><I><S><V><N><G><R><M><R><N><N><I><K><T><G><S><S><P><N><S><V><S><S><S><P><T><N><S><A><I><T><Q><L><R><N><K><L><E><N><G><K><P><L><S><M><S><E><Q><T><G><L><L><K><I><K><T><E><P><L><D><F><N><D><Y><K><V><L><M><A><T><H><G><F><S><G><T><S><P><F><M><N><G><G><L><G><A><T><S><P><L><G><V><H><P><S><A><Q><S><P><M><Q><H><L><G><V><G><M><E><A><P><L><L><G><F><P><T><M><N><S><N><L><S><E><V><Q><K><V><L><Q><I><V><D><N><T><V><S><R><Q><K><M><D><C><K><A><E><E><I><S><K><L><K><G><Y><H><M><K><D><P><C><S><Q><P><E><E><Q><G><V><T><S><P><N><I><P><P><V><G><L><P><V><V><S><H><N><G><A><T><K><S><I><I><D><Y><T><L><E><K><V><N><E><A><K><A><C><L><Q><S><L><T><T><D><S><R><R><Q><I><S><N><I><K><K><E><K><L><R><T><L><I><D><L><V><T><D><D><K><M><I><E><N><H><N><I><S><T><P><F><S><C><Q><F><C><K><E><S><F><P><G><P><I><P><L><H><Q><H><E><R><Y><L><C><K><M><N><E><E><I><K><A><V><L><Q><P><H><E><N><I><V><P><N><K><A><G><V><F><V><D><N><K><A><L><L><L><S><S><V><L><S><E><K><G><M><T><S><P><I><N><P><Y><K><D><H><M><S><V><L><K><A><Y><Y><A><M><N><M><E><P><N><S><D><E><L><L><K><I><S><I><A><V><G><L><P><Q><E><F><V><K><E><W><F><E><Q><R><K><V><Y><Q><Y><S><N><S><R><S><P><S><L><E><R><S><S><K><P><L><A><P><N><S><N><P><P><T><K><D><S><L><L><P><R><S><P><V><K><P><M><D><S><I><T><S><P><S><I><A><E><L><H><N><S><V><T><N><C><D><P><P><L><R><L><T><K><P><S><H><F><T><N><I><K><P><V><E><K><L><D><H><S><R><S><N><T><P><S><P><L><N><L><S><S><T><S><S><K><N><S><H><S><S><S><Y><T><P><N><S><F><S><S><E><E><L><Q><A><E><P><L><D><L><S><L><P><K><Q><M><K><E><P><K><S><I><I><A><T><K><N><K><T><K><A><S><S><I><S><L><D><H><N><S><V><S><S><S><S><E><N><S><D><E><P><L><N><L><T><F><I><K><K><E><F><S><N><S><N><N><L><D><N><K><S><T><N><P><V><F><S><M><N><P><F><S><A><K><P><L><Y><T><A><L><P><P><Q><S><A><F><P><P><A><T><F><M><P><P><V><Q><T><S><I><P><G><L><R><P><Y><P><G><L><D><Q><M><S><F><L><P><H><M><A><Y><T><Y><P><T><G><A><A><T><F><A><D><M><Q><Q><R><R><K><Y><Q><R><K><Q><G><F><Q><G><E><L><L><D><G><A><Q><D><Y><M><S><G><L><D><D><M><T><D><S><D><S><C><L><S><R><K><K><I><K><K><T><E><S><G><M><Y><A><C><D><L><C><D><K><T><F><Q><K><S><S><S><L><L><R><H><K><Y><E><H><T><G><K><R><P><H><Q><C><Q><I><C><K><K><A><F><K><H><K><H><H><L><I><E><H><S><R><L><H><S><G><E><K><P><Y><Q><C><D><K><C><G><K><R><F><S><H><S><G><S><Y><S><Q><H><M><N><H><R><Y><S><Y><C><K><R><E><A><E><E><R><E><A><A><E><R><E><A><R><E><K><G><H><L><E><P><T><E><L><L><M><N><R><A><Y><L><Q><S><I><T><P><Q><G><Y><S><D><S><E><E><R><E><S><M><P><R><D><G><E><S><E><K><E><H><E><K><E><G><E><D><G><Y><G><K><L><G><R><Q><D><G><D><E><E><F><E><E><E><E><E><E><S><E><N><K><S><M><D><T><D><P><E><T><I><R><D><E><E><E><T><G><D><H><S><M><D><D><S><S><E><D><G><K><M><E><T><K><S><D><H><E><E><D><N><M><E><D><G><M>
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2.<BOP>
Q96T17
<M><E><R><G><G><G><G><S><G><T><G><S><R><P><E><G><T><A><R><G><T><S><L><P><G><K><I><A><E><P><G><A><V><R><T><S><Q><P><N><Y><R><P><Q><G><M><E><G><F><L><K><S><D><E><R><Q><R><L><A><K><E><R><R><E><E><R><E><K><C><L><A><A><R><E><Q><Q><I><L><E><K><Q><K><R><A><R><L><Q><Y><E><K><Q><M><E><E><R><W><R><K><L><E><E><Q><R><Q><R><E><D><Q><K><R><A><A><V><E><E><K><R><K><Q><K><L><R><E><E><E><E><R><L><E><A><M><M><R><R><S><L><E><R><T><Q><Q><L><E><L><K><K><K><Y><S><W><G><A><P><L><A><I><G><P><G><G><H><D><A><C><D><K><L><S><T><S><T><M><S><L><P><K><P><T><E><P><P><M><N><K><R><L><S><S><S><T><V><A><I><S><Y><S><P><D><R><V><F><H><V><C><P><R><L><A><P><L><G><P><L><N><P><S><Y><K><S><S><P><T><R><N><I><E><K><K><K><A><T><S><T><S><T><S><G><A><G><D><V><G><K><E><A><L><S><G><G><E><A><S><L><V><E><K><V><K><R><G><Q><R><T><A><T><S><L><P><V><V><N><F><G><S><P><L><R><R><C><E><F><S><G><G><I><P><K><R><P><S><S><P><V><I><S><K><T><A><T><K><A><Y><P><Q><S><P><K><T><T><K><P><P><Y><P><G><S><P><V><K><Y><R><L><P><A><L><S><G><Q><D><M><P><K><R><K><A><E><K><E><K><S><N><K><E><R><E><G><T><L><A><Q><Q><A><A><G><P><Q><G><E><E><A><L><E><K><H><V><V><D><K><H><A><S><E><K><H><A><A><A><A><G><G><K><A><E><N><S><A><A><L><G><K><P><T><A><G><T><T><D><A><G><E><A><A><K><I><L><A><E><K><R><R><Q><A><R><L><Q><K><E><Q><E><E><Q><E><R><L><E><K><E><E><Q><D><R><L><E><R><E><E><L><K><R><K><A><E><E><E><R><L><R><L><E><E><E><A><R><K><Q><E><E><E><R><K><R><Q><E><E><E><K><K><K><Q><E><G><E><E><K><R><K><A><G><E><E><A><K><R><K><A><E><E><E><L><L><L><K><E><K><Q><E><Q><E><K><Q><E><K><A><M><I><E><K><Q><K><E><A><A><E><T><K><A><R><E><V><A><E><Q><M><R><L><E><R><E><Q><I><M><L><Q><I><E><Q><E><R><L><E><R><K><K><R><I><D><E><I><M><K><R><T><R><K><S><D><V><S><P><Q><V><K><K><E><D><P><K><V><G><V><Q><P><A><V><C><V><E><K><K><T><K><L><V><V><P><N><K><M><E><I><N><G><L><N><T><C><Q><E><V><N><G><V><D><H><A><A><P><E><T><Y><P><Q><D><I><F><S><N><G><L><K><P><A><G><G><L><I><H><L><D><A><L><D><G><K><S><N><S><L><D><D><S><T><E><E><V><Q><S><M><D><V><S><P><V><S><K><E><E><L><I><S><I><P><E><F><S><P><V><S><E><M><I><P><G><V><S><L><D><Q><N><G><T><G><N><A><R><A><L><Q><D><L><L><D><F><T><G><P><P><T><F><P><K><R><S><S><E><N><L><S><L><D><D><C><N><K><N><L><I><E><G><F><N><S><P><G><Q><E><T><P><L><N><T><F><C>
Microtubule-stabilizing protein that plays a role in the control of cell motility and neurite outgrowth via direct binding to the microtubule. Acts as a critical cofactor for kinesin transport. In the proximal axon, regulates kinesin-1 family members, KIF5A, KIF5B and KIF5C recruitment to microtubules and contributes to kinesin-1-mediated transport in the axons.<BOP>
Q9Y233
<M><A><S><L><E><E><P><L><A><P><R><P><Q><G><P><L><P><A><A><G><D><E><P><G><C><G><P><G><K><L><R><P><E><P><R><L><S><A><A><G><G><G><S><A><A><G><P><G><P><A><P><E><W><P><G><R><G><R><A><E><R><A><A><P><P><R><P><P><L><S><S><A><G><R><P><S><P><A><G><G><P><G><A><L><S><A><R><G><G><G><C><G><W><V><A><A><R><A><P><L><A><L><A><F><S><S><R><V><P><S><S><S><P><S><F><F><Y><F><W><P><P><P><P><P><P><P><P><S><F><L><P><S><S><S><A><F><H><L><P><V><R><L><P><G><R><E><G><A><A><A><A><A><A><A><G><G><G><G><D><A><G><G><G><G><G><G><G><Q><E><A><A><P><L><S><V><P><T><S><S><S><H><R><G><G><G><G><S><G><G><G><R><R><R><L><F><L><S><P><A><L><Q><G><L><L><L><P><A><R><A><G><P><R><P><P><P><P><P><R><L><P><L><G><Q><A><A><R><R><A><G><S><P><G><F><P><G><A><G><P><G><G><G><G><Q><T><P><R><R><P><Q><G><A><S><F><A><L><A><A><A><A><A><L><L><F><G><S><D><M><E><D><G><P><S><N><N><A><S><C><F><R><R><L><T><E><C><F><L><S><P><S><L><T><D><E><K><V><K><A><Y><L><S><L><H><P><Q><V><L><D><E><F><V><S><E><S><V><S><A><E><T><V><E><K><W><L><K><R><K><N><N><K><S><E><D><E><S><A><P><K><E><V><S><R><Y><Q><D><T><N><M><Q><G><V><V><Y><E><L><N><S><Y><I><E><Q><R><L><D><T><G><G><D><N><Q><L><L><L><Y><E><L><S><S><I><I><K><I><A><T><K><A><D><G><F><A><L><Y><F><L><G><E><C><N><N><S><L><C><I><F><T><P><P><G><I><K><E><G><K><P><R><L><I><P><A><G><P><I><T><Q><G><T><T><V><S><A><Y><V><A><K><S><R><K><T><L><L><V><E><D><I><L><G><D><E><R><F><P><R><G><T><G><L><E><S><G><T><R><I><Q><S><V><L><C><L><P><I><V><T><A><I><G><D><L><I><G><I><L><E><L><Y><R><H><W><G><K><E><A><F><C><L><S><H><Q><E><V><A><T><A><N><L><A><W><A><S><V><A><I><H><Q><V><Q><V><C><R><G><L><A><K><Q><T><E><L><N><D><F><L><L><D><V><S><K><T><Y><F><D><N><I><V><A><I><D><S><L><L><E><H><I><M><I><Y><A><K><N><L><V><N><A><D><R><C><A><L><F><Q><V><D><H><K><N><K><E><L><Y><S><D><L><F><D><I><G><E><E><K><E><G><K><P><V><F><K><K><T><K><E><I><R><F><S><I><E><K><G><I><A><G><Q><V><A><R><T><G><E><V><L><N><I><P><D><A><Y><A><D><P><R><F><N><R><E><V><D><L><Y><T><G><Y><T><T><R><N><I><L><C><M><P><I><V><S><R><G><S><V><I><G><V><V><Q><M><V><N><K><I><S><G><S><A><F><S><K><T><D><E><N><N><F><K><M><F><A><V><F><C><A><L><A><L><H><C><A><N><M><Y><H><R><I><R><H><S><E><C><I><Y><R><V><T><M><E><K><L><S><Y><H><S><I><C><T><S><E><E><W><Q><G><L><M><Q><F><T><L><P><V><R><L><C><K><E><I><E><L><F><H><F><D><I><G><P><F><E><N><M><W><P><G><I><F><V><Y><M><V><H><R><S><C><G><T><S><C><F><E><L><E><K><L><C><R><F><I><M><S><V><K><K><N><Y><R><R><V><P><Y><H><N><W><K><H><A><V><T><V><A><H><C><M><Y><A><I><L><Q><N><N><H><T><L><F><T><D><L><E><R><K><G><L><L><I><A><C><L><C><H><D><L><D><H><R><G><F><S><N><S><Y><L><Q><K><F><D><H><P><L><A><A><L><Y><S><T><S><T><M><E><Q><H><H><F><S><Q><T><V><S><I><L><Q><L><E><G><H><N><I><F><S><T><L><S><S><S><E><Y><E><Q><V><L><E><I><I><R><K><A><I><I><A><T><D><L><A><L><Y><F><G><N><R><K><Q><L><E><E><M><Y><Q><T><G><S><L><N><L><N><N><Q><S><H><R><D><R><V><I><G><L><M><M><T><A><C><D><L><C><S><V><T><K><L><W><P><V><T><K><L><T><A><N><D><I><Y><A><E><F><W><A><E><G><D><E><M><K><K><L><G><I><Q><P><I><P><M><M><D><R><D><K><K><D><E><V><P><Q><G><Q><L><G><F><Y><N><A><V><A><I><P><C><Y><T><T><L><T><Q><I><L><P><P><T><E><P><L><L><K><A><C><R><D><N><L><S><Q><W><E><K><V><I><R><G><E><E><T><A><T><W><I><S><S><P><S><V><A><Q><K><A><A><A><S><E><D>
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.<BOP>
O75970
<M><L><E><A><I><D><K><N><R><A><L><H><A><A><E><R><L><Q><T><K><L><R><E><R><G><D><V><A><N><E><D><K><L><S><L><L><K><S><V><L><Q><S><P><L><F><S><Q><I><L><S><L><Q><T><S><V><Q><Q><L><K><D><Q><V><N><I><A><T><S><A><T><S><N><I><E><Y><A><H><V><P><H><L><S><P><A><V><I><P><T><L><Q><N><E><S><F><L><L><S><P><N><N><G><N><L><E><A><L><T><G><P><G><I><P><H><I><N><G><K><P><A><C><D><E><F><D><Q><L><I><K><N><M><A><Q><G><R><H><V><E><V><F><E><L><L><K><P><P><S><G><G><L><G><F><S><V><V><G><L><R><S><E><N><R><G><E><L><G><I><F><V><Q><E><I><Q><E><G><S><V><A><H><R><D><G><R><L><K><E><T><D><Q><I><L><A><I><N><G><Q><A><L><D><Q><T><I><T><H><Q><Q><A><I><S><I><L><Q><K><A><K><D><T><V><Q><L><V><I><A><R><G><S><L><P><Q><L><V><S><P><I><V><S><R><S><P><S><A><A><S><T><I><S><A><H><S><N><P><V><H><W><Q><H><M><E><T><I><E><L><V><N><D><G><S><G><L><G><F><G><I><I><G><G><K><A><T><G><V><I><V><K><T><I><L><P><G><G><V><A><D><Q><H><G><R><L><C><S><G><D><H><I><L><K><I><G><D><T><D><L><A><G><M><S><S><E><Q><V><A><Q><V><L><R><Q><C><G><N><R><V><K><L><M><I><A><R><G><A><I><E><E><R><T><A><P><T><A><L><G><I><T><L><S><S><S><P><T><S><T><P><E><L><R><V><D><A><S><T><Q><K><G><E><E><S><E><T><F><D><V><E><L><T><K><N><V><Q><G><L><G><I><T><I><A><G><Y><I><G><D><K><K><L><E><P><S><G><I><F><V><K><S><I><T><K><S><S><A><V><E><H><D><G><R><I><Q><I><G><D><Q><I><I><A><V><D><G><T><N><L><Q><G><F><T><N><Q><Q><A><V><E><V><L><R><H><T><G><Q><T><V><L><L><T><L><M><R><R><G><M><K><Q><E><A><E><L><M><S><R><E><D><V><T><K><D><A><D><L><S><P><V><N><A><S><I><I><K><E><N><Y><E><K><D><E><D><F><L><S><S><T><R><N><T><N><I><L><P><T><E><E><E><G><Y><P><L><L><S><A><E><I><E><E><I><E><D><A><Q><K><Q><E><A><A><L><L><T><K><W><Q><R><I><M><G><I><N><Y><E><I><V><V><A><H><V><S><K><F><S><E><N><S><G><L><G><I><S><L><E><A><T><V><G><H><H><F><I><R><S><V><L><P><E><G><P><V><G><H><S><G><K><L><F><S><G><D><E><L><L><E><V><N><G><I><T><L><L><G><E><N><H><Q><D><V><V><N><I><L><K><E><L><P><I><E><V><T><M><V><C><C><R><R><T><V><P><P><T><T><Q><S><E><L><D><S><L><D><L><C><D><I><E><L><T><E><K><P><H><V><D><L><G><E><F><I><G><S><S><E><T><E><D><P><V><L><A><M><T><D><A><G><Q><S><T><E><E><V><Q><A><P><L><A><M><W><E><A><G><I><Q><H><I><E><L><E><K><G><S><K><G><L><G><F><S><I><L><D><Y><Q><D><P><I><D><P><A><S><T><V><I><I><I><R><S><L><V><P><G><G><I><A><E><K><D><G><R><L><L><P><G><D><R><L><M><F><V><N><D><V><N><L><E><N><S><S><L><E><E><A><V><E><A><L><K><G><A><P><S><G><T><V><R><I><G><V><A><K><P><L><P><L><S><P><E><E><G><Y><V><S><A><K><E><D><S><F><L><Y><P><P><H><S><C><E><E><A><G><L><A><D><K><P><L><F><R><A><D><L><A><L><V><G><T><N><D><A><D><L><V><D><E><S><T><F><E><S><P><Y><S><P><E><N><D><S><I><Y><S><T><Q><A><S><I><L><S><L><H><G><S><S><C><G><D><G><L><N><Y><G><S><S><L><P><S><S><P><P><K><D><V><I><E><N><S><C><D><P><V><L><D><L><H><M><S><L><E><E><L><Y><T><Q><N><L><L><Q><R><Q><D><E><N><T><P><S><V><D><I><S><M><G><P><A><S><G><F><T><I><N><D><Y><T><P><A><N><A><I><E><Q><Q><Y><E><C><E><N><T><I><V><W><T><E><S><H><L><P><S><E><V><I><S><S><A><E><L><P><S><V><L><P><D><S><A><G><K><G><S><E><Y><L><L><E><Q><S><S><L><A><C><N><A><E><C><V><M><L><Q><N><V><S><K><E><S><F><E><R><T><I><N><I><A><K><G><N><S><S><L><G><M><T><V><S><A><N><K><D><G><L><G><M><I><V><R><S><I><I><H><G><G><A><I><S><R><D><G><R><I><A><I><G><D><C><I><L><S><I><N><E><E><S><T><I><S><V><T><N><A><Q><A><R><A><M><L><R><R><H><S><L><I><G><P><D><I><K><I><T><Y><V><P><A><E><H><L><E><E><F><K><I><S><L><G><Q><Q><S><G><R><V><M><A><L><D><I><F><S><S><Y><T><G><R><D><I><P><E><L><P><E><R><E><E><G><E><G><E><E><S><E><L><Q><N><T><A><Y><S><N><W><N><Q><P><R><R><V><E><L><W><R><E><P><S><K><S><L><G><I><S><I><V><G><G><R><G><M><G><S><R><L><S><N><G><E><V><M><R><G><I><F><I><K><H><V><L><E><D><S><P><A><G><K><N><G><T><L><K><P><G><D><R><I><V><E><V><D><G><M><D><L><R><D><A><S><H><E><Q><A><V><E><A><I><R><K><A><G><N><P><V><V><F><M><V><Q><S><I><I><N><R><P><R><K><S><P><L><P><S><L><L><H><N><L><Y><P><K><Y><N><F><S><S><T><N><P><F><A><D><S><L><Q><I><N><A><D><K><A><P><S><Q><S><E><S><E><P><E><K><A><P><L><C><S><V><P><P><P><P><P><S><A><F><A><E><M><G><S><D><H><T><Q><S><S><A><S><K><I><S><Q><D><V><D><K><E><D><E><F><G><Y><S><W><K><N><I><R><E><R><Y><G><T><L><T><G><E><L><H><M><I><E><L><E><K><G><H><S><G><L><G><L><S><L><A><G><N><K><D><R><S><R><M><S><V><F><I><V><G><I><D><P><N><G><A><A><G><K><D><G><R><L><Q><I><A><D><E><L><L><E><I><N><G><Q><I><L><Y><G><R><S><H><Q><N><A><S><S><I><I><K><C><A><P><S><K><V><K><I><I><F><I><R><N><K><D><A><V><N><Q><M><A><V><C><P><G><N><A><V><E><P><L><P><S><N><S><E><N><L><Q><N><K><E><T><E><P><T><V><T><T><S><D><A><A><V><D><L><S><S><F><K><N><V><Q><H><L><E><L><P><K><D><Q><G><G><L><G><I><A><I><S><E><E><D><T><L><S><G><V><I><I><K><S><L><T><E><H><G><V><A><A><T><D><G><R><L><K><V><G><D><Q><I><L><A><V><D><D><E><I><V><V><G><Y><P><I><E><K><F><I><S><L><L><K><T><A><K><M><T><V><K><L><T><I><H><A><E><N><P><D><S><Q><A><V><P><S><A><A><G><A><A><S><G><E><K><K><N><S><S><Q><S><L><M><V><P><Q><S><G><S><P><E><P><E><S><I><R><N><T><S><R><S><S><T><P><A><I><F><A><S><D><P><A><T><C><P><I><I><P><G><C><E><T><T><I><E><I><S><K><G><R><T><G><L><G><L><S><I><V><G><G><S><D><T><L><L><G><A><I><I><I><H><E><V><Y><E><E><G><A><A><C><K><D><G><R><L><W><A><G><D><Q><I><L><E><V><N><G><I><D><L><R><K><A><T><H><D><E><A><I><N><V><L><R><Q><T><P><Q><R><V><R><L><T><L><Y><R><D><E><A><P><Y><K><E><E><E><V><C><D><T><L><T><I><E><L><Q><K><K><P><G><K><G><L><G><L><S><I><V><G><K><R><N><D><T><G><V><F><V><S><D><I><V><K><G><G><I><A><D><A><D><G><R><L><M><Q><G><D><Q><I><L><M><V><N><G><E><D><V><R><N><A><T><Q><E><A><V><A><A><L><L><K><C><S><L><G><T><V><T><L><E><V><G><R><I><K><A><G><P><F><H><S><E><R><R><P><S><Q><S><S><Q><V><S><E><G><S><L><S><S><F><T><F><P><L><S><G><S><S><T><S><E><S><L><E><S><S><S><K><K><N><A><L><A><S><E><I><Q><G><L><R><T><V><E><M><K><K><G><P><T><D><S><L><G><I><S><I><A><G><G><V><G><S><P><L><G><D><V><P><I><F><I><A><M><M><H><P><T><G><V><A><A><Q><T><Q><K><L><R><V><G><D><R><I><V><T><I><C><G><T><S><T><E><G><M><T><H><T><Q><A><V><N><L><L><K><N><A><S><G><S><I><E><M><Q><V><V><A><G><G><D><V><S><V><V><T><G><H><Q><Q><E><P><A><S><S><S><L><S><F><T><G><L><T><S><S><S><I><F><Q><D><D><L><G><P><P><Q><C><K><S><I><T><L><E><R><G><P><D><G><L><G><F><S><I><V><G><G><Y><G><S><P><H><G><D><L><P><I><Y><V><K><T><V><F><A><K><G><A><A><S><E><D><G><R><L><K><R><G><D><Q><I><I><A><V><N><G><Q><S><L><E><G><V><T><H><E><E><A><V><A><I><L><K><R><T><K><G><T><V><T><L><M><V><L><S>
Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.<BOP>
P12724
<M><V><P><K><L><F><T><S><Q><I><C><L><L><L><L><L><G><L><M><G><V><E><G><S><L><H><A><R><P><P><Q><F><T><R><A><Q><W><F><A><I><Q><H><I><S><L><N><P><P><R><C><T><I><A><M><R><A><I><N><N><Y><R><W><R><C><K><N><Q><N><T><F><L><R><T><T><F><A><N><V><V><N><V><C><G><N><Q><S><I><R><C><P><H><N><R><T><L><N><N><C><H><R><S><R><F><R><V><P><L><L><H><C><D><L><I><N><P><G><A><Q><N><I><S><N><C><T><Y><A><D><R><P><G><R><R><F><Y><V><V><A><C><D><N><R><D><P><R><D><S><P><R><Y><P><V><V><P><V><H><L><D><T><T><I>
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.<BOP>
Q8WZ55
<M><A><D><E><K><T><F><R><I><G><F><I><V><L><G><L><F><L><L><A><L><G><T><F><L><M><S><H><D><R><P><Q><V><Y><G><T><F><Y><A><M><G><S><V><M><V><I><G><G><I><I><W><S><M><C><Q><C><Y><P><K><I><T><F><V><P><A><D><S><D><F><Q><G><I><L><S><P><K><A><M><G><L><L><E><N><G><L><A><A><E><M><K><S><P><S><P><Q><P><P><Y><V><R><L><W><E><E><A><A><Y><D><Q><S><L><P><D><F><S><H><I><Q><M><K><V><M><S><Y><S><E><D><H><R><S><L><L><A><P><E><M><G><Q><P><K><L><G><T><S><D><G><G><E><G><G><P><G><D><V><Q><A><W><M><E><A><A><V><V><I><H><K><G><S><D><E><S><E><G><E><R><R><L><T><Q><S><W><P><G><P><L><A><C><P><Q><G><P><A><P><L><A><S><F><Q><D><D><L><D><M><D><S><S><E><G><S><S><P><N><A><S><P><H><D><R><E><E><A><C><S><P><Q><Q><E><P><Q><G><C><R><C><P><L><D><R><F><Q><D><F><A><L><I><D><A><P><T><L><E><D><E><P><Q><E><G><Q><Q><W><E><I><A><L><P><N><N><W><Q><R><Y><P><R><T><K><V><E><E><K><E><A><S><D><T><G><G><E><E><P><E><K><E><E><E><D><L><Y><Y><G><L><P><D><G><A><G><D><L><L><P><D><K><E><L><G><F><E><P><D><T><Q><G>
Regulatory subunit of anion-selective CLCNKA:BSND and CLCNKB:BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing. Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA:BSND and CLCNKB:BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates.<BOP>
Q9Y6N8
<M><T><I><H><Q><F><L><L><L><F><L><F><W><V><C><L><P><H><F><C><S><P><E><I><M><F><R><R><T><P><V><P><Q><Q><R><I><L><S><S><R><V><P><R><S><D><G><K><I><L><H><R><Q><K><R><G><W><M><W><N><Q><F><F><L><L><E><E><Y><T><G><S><D><Y><Q><Y><V><G><K><L><H><S><D><Q><D><K><G><D><G><S><L><K><Y><I><L><S><G><D><G><A><G><T><L><F><I><I><D><E><K><T><G><D><I><H><A><T><R><R><I><D><R><E><E><K><A><F><Y><T><L><R><A><Q><A><I><N><R><R><T><L><R><P><V><E><P><E><S><E><F><V><I><K><I><H><D><I><N><D><N><E><P><T><F><P><E><E><I><Y><T><A><S><V><P><E><M><S><V><V><G><T><S><V><V><Q><V><T><A><T><D><A><D><D><P><S><Y><G><N><S><A><R><V><I><Y><S><I><L><Q><G><Q><P><Y><F><S><V><E><P><E><T><G><I><I><R><T><A><L><P><N><M><N><R><E><N><R><E><Q><Y><Q><V><V><I><Q><A><K><D><M><G><G><Q><M><G><G><L><S><G><T><T><T><V><N><I><T><L><T><D><V><N><D><N><P><P><R><F><P><Q><N><T><I><H><L><R><V><L><E><S><S><P><V><G><T><A><I><G><S><V><K><A><T><D><A><D><T><G><K><N><A><E><V><E><Y><R><I><I><D><G><D><G><T><D><M><F><D><I><V><T><E><K><D><T><Q><E><G><I><I><T><V><K><K><P><L><D><Y><E><S><R><R><L><Y><T><L><K><V><E><A><E><N><T><H><V><D><P><R><F><Y><Y><L><G><P><F><K><D><T><T><I><V><K><I><S><I><E><D><V><D><E><P><P><V><F><S><R><S><S><Y><L><F><E><V><H><E><D><I><E><V><G><T><I><I><G><T><V><M><A><R><D><P><D><S><I><S><S><P><I><R><F><S><L><D><R><H><T><D><L><D><R><I><F><N><I><H><S><G><N><G><S><L><Y><T><S><K><P><L><D><R><E><L><S><Q><W><H><N><L><T><V><I><A><A><E><I><N><N><P><K><E><T><T><R><V><A><V><F><V><R><I><L><D><V><N><D><N><A><P><Q><F><A><V><F><Y><D><T><F><V><C><E><N><A><R><P><G><Q><L><I><Q><T><I><S><A><V><D><K><D><D><P><L><G><G><Q><K><F><F><F><S><L><A><A><V><N><P><N><F><T><V><Q><D><N><E><D><N><T><A><R><I><L><T><R><K><N><G><F><N><R><H><E><I><S><T><Y><L><L><P><V><V><I><S><D><N><D><Y><P><I><Q><S><S><T><G><T><L><T><I><R><V><C><A><C><D><S><Q><G><N><M><Q><S><C><S><A><E><A><L><L><L><P><A><G><L><S><T><G><A><L><I><A><I><L><L><C><I><I><I><L><L><V><I><V><V><L><F><A><A><L><K><R><Q><R><K><K><E><P><L><I><L><S><K><E><D><I><R><D><N><I><V><S><Y><N><D><E><G><G><G><E><E><D><T><Q><A><F><D><I><G><T><L><R><N><P><A><A><I><E><E><K><K><L><R><R><D><I><I><P><E><T><L><F><I><P><R><R><T><P><T><A><P><D><N><T><D><V><R><D><F><I><N><E><R><L><K><E><H><D><L><D><P><T><A><P><P><Y><D><S><L><A><T><Y><A><Y><E><G><N><D><S><I><A><E><S><L><S><S><L><E><S><G><T><T><E><G><D><Q><N><Y><D><Y><L><R><E><W><G><P><R><F><N><K><L><A><E><M><Y><G><G><G><E><S><D><K><D><S>
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.<BOP>
Q9NP78
<M><R><L><W><K><A><V><V><V><T><L><A><F><M><S><V><D><I><C><V><T><T><A><I><Y><V><F><S><H><L><D><R><S><L><L><E><D><I><R><H><F><N><I><F><D><S><V><L><D><L><W><A><A><C><L><Y><R><S><C><L><L><L><G><A><T><I><G><V><A><K><N><S><A><L><G><P><R><R><L><R><A><S><W><L><V><I><T><L><V><C><L><F><V><G><I><Y><A><M><V><K><L><L><L><F><S><E><V><R><R><P><I><R><D><P><W><F><W><A><L><F><V><W><T><Y><I><S><L><G><A><S><F><L><L><W><W><L><L><S><T><V><R><P><G><T><Q><A><L><E><P><G><A><A><T><E><A><E><G><F><P><G><S><G><R><P><P><P><E><Q><A><S><G><A><T><L><Q><K><L><L><S><Y><T><K><P><D><V><A><F><L><V><A><A><S><F><F><L><I><V><A><A><L><G><E><T><F><L><P><Y><Y><T><G><R><A><I><D><G><I><V><I><Q><K><S><M><D><Q><F><S><T><A><V><V><I><V><C><L><L><A><I><G><S><S><F><A><A><G><I><R><G><G><I><F><T><L><I><F><A><R><L><N><I><R><L><R><N><C><L><F><R><S><L><V><S><Q><E><T><S><F><F><D><E><N><R><T><G><D><L><I><S><R><L><T><S><D><T><T><M><V><S><D><L><V><S><Q><N><I><N><V><F><L><R><N><T><V><K><V><T><G><V><V><V><F><M><F><S><L><S><W><Q><L><S><L><V><T><F><M><G><F><P><I><I><M><M><V><S><N><I><Y><G><K><Y><Y><K><R><L><S><K><E><V><Q><N><A><L><A><R><A><S><N><T><A><E><E><T><I><S><A><M><K><T><V><R><S><F><A><N><E><E><E><E><A><E><V><Y><L><R><K><L><Q><Q><V><Y><K><L><N><R><K><E><A><A><A><Y><M><Y><Y><V><W><G><S><G><L><T><L><L><V><V><Q><V><S><I><L><Y><Y><G><G><H><L><V><I><S><G><Q><M><T><S><G><N><L><I><A><F><I><I><Y><E><F><V><L><G><D><C><M><E><S><V><G><S><V><Y><S><G><L><M><Q><G><V><G><A><A><E><K><V><F><E><F><I><D><R><Q><P><T><M><V><H><D><G><S><L><A><P><D><H><L><E><G><R><V><D><F><E><N><V><T><F><T><Y><R><T><R><P><H><T><Q><V><L><Q><N><V><S><F><S><L><S><P><G><K><V><T><A><L><V><G><P><S><G><S><G><K><S><S><C><V><N><I><L><E><N><F><Y><P><L><E><G><G><R><V><L><L><D><G><K><P><I><S><A><Y><D><H><K><Y><L><H><R><V><I><S><L><V><S><Q><E><P><V><L><F><A><R><S><I><T><D><N><I><S><Y><G><L><P><T><V><P><F><E><M><V><V><E><A><A><Q><K><A><N><A><H><G><F><I><M><E><L><Q><D><G><Y><S><T><E><T><G><E><K><G><A><Q><L><S><G><G><Q><K><Q><R><V><A><M><A><R><A><L><V><R><N><P><P><V><L><I><L><D><E><A><T><S><A><L><D><A><E><S><E><Y><L><I><Q><Q><A><I><H><G><N><L><Q><K><H><T><V><L><I><I><A><H><R><L><S><T><V><E><H><A><H><L><I><V><V><L><D><K><G><R><V><V><Q><Q><G><T><H><Q><Q><L><L><A><Q><G><G><L><Y><A><K><L><V><Q><R><Q><M><L><G><L><Q><P><A><A><D><F><T><A><G><H><N><E><P><V><A><N><G><S><H><K><A>
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Binds and transports smaller and larger peptides with the same affinity. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.<BOP>
O75521
<M><A><M><A><Y><L><A><W><R><L><A><R><R><S><C><P><S><S><L><Q><V><T><S><F><P><V><V><Q><L><H><M><N><R><T><A><M><R><A><S><Q><K><D><F><E><N><S><M><N><Q><V><K><L><L><K><K><D><P><G><N><E><V><K><L><K><L><Y><A><L><Y><K><Q><A><T><E><G><P><C><N><M><P><K><P><G><V><F><D><L><I><N><K><A><K><W><D><A><W><N><A><L><G><S><L><P><K><E><A><A><R><Q><N><Y><V><D><L><V><S><S><L><S><P><S><L><E><S><S><S><Q><V><E><P><G><T><D><R><K><S><T><G><F><E><T><L><V><V><T><S><E><D><G><I><T><K><I><M><F><N><R><P><K><K><K><N><A><I><N><T><E><M><Y><H><E><I><M><R><A><L><K><A><A><S><K><D><D><S><I><I><T><V><L><T><G><N><G><D><Y><Y><S><S><G><N><D><L><T><N><F><T><D><I><P><P><G><G><V><E><E><K><A><K><N><N><A><V><L><L><R><E><F><V><G><C><F><I><D><F><P><K><P><L><I><A><V><V><N><G><P><A><V><G><I><S><V><T><L><L><G><L><F><D><A><V><Y><A><S><D><R><A><T><F><H><T><P><F><S><H><L><G><Q><S><P><E><G><C><S><S><Y><T><F><P><K><I><M><S><P><A><K><A><T><E><M><L><I><F><G><K><K><L><T><A><G><E><A><C><A><Q><G><L><V><T><E><V><F><P><D><S><T><F><Q><K><E><V><W><T><R><L><K><A><F><A><K><L><P><P><N><A><L><R><I><S><K><E><V><I><R><K><R><E><R><E><K><L><H><A><V><N><A><E><E><C><N><V><L><Q><G><R><W><L><S><D><E><C><T><N><A><V><V><N><F><L><S><R><K><S><K><L>
Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.<BOP>
P46098
<M><L><L><W><V><Q><Q><A><L><L><A><L><L><L><P><T><L><L><A><Q><G><E><A><R><R><S><R><N><T><T><R><P><A><L><L><R><L><S><D><Y><L><L><T><N><Y><R><K><G><V><R><P><V><R><D><W><R><K><P><T><T><V><S><I><D><V><I><V><Y><A><I><L><N><V><D><E><K><N><Q><V><L><T><T><Y><I><W><Y><R><Q><Y><W><T><D><E><F><L><Q><W><N><P><E><D><F><D><N><I><T><K><L><S><I><P><T><D><S><I><W><V><P><D><I><L><I><N><E><F><V><D><V><G><K><S><P><N><I><P><Y><V><Y><I><R><H><Q><G><E><V><Q><N><Y><K><P><L><Q><V><V><T><A><C><S><L><D><I><Y><N><F><P><F><D><V><Q><N><C><S><L><T><F><T><S><W><L><H><T><I><Q><D><I><N><I><S><L><W><R><L><P><E><K><V><K><S><D><R><S><V><F><M><N><Q><G><E><W><E><L><L><G><V><L><P><Y><F><R><E><F><S><M><E><S><S><N><Y><Y><A><E><M><K><F><Y><V><V><I><R><R><R><P><L><F><Y><V><V><S><L><L><L><P><S><I><F><L><M><V><M><D><I><V><G><F><Y><L><P><P><N><S><G><E><R><V><S><F><K><I><T><L><L><L><G><Y><S><V><F><L><I><I><V><S><D><T><L><P><A><T><A><I><G><T><P><L><I><G><V><Y><F><V><V><C><M><A><L><L><V><I><S><L><A><E><T><I><F><I><V><R><L><V><H><K><Q><D><L><Q><Q><P><V><P><A><W><L><R><H><L><V><L><E><R><I><A><W><L><L><C><L><R><E><Q><S><T><S><Q><R><P><P><A><T><S><Q><A><T><K><T><D><D><C><S><A><M><G><N><H><C><S><H><M><G><G><P><Q><D><F><E><K><S><P><R><D><R><C><S><P><P><P><P><P><R><E><A><S><L><A><V><C><G><L><L><Q><E><L><S><S><I><R><Q><F><L><E><K><R><D><E><I><R><E><V><A><R><D><W><L><R><V><G><S><V><L><D><K><L><L><F><H><I><Y><L><L><A><V><L><A><Y><S><I><T><L><V><M><L><W><S><I><W><Q><Y><A>
Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.<BOP>
Q99638
<M><K><C><L><V><T><G><G><N><V><K><V><L><G><K><A><V><H><S><L><S><R><I><G><D><E><L><Y><L><E><P><L><E><D><G><L><S><L><R><T><V><N><S><S><R><S><A><Y><A><C><F><L><F><A><P><L><F><F><Q><Q><Y><Q><A><A><T><P><G><Q><D><L><L><R><C><K><I><L><M><K><S><F><L><S><V><F><R><S><L><A><M><L><E><K><T><V><E><K><C><C><I><S><L><N><G><R><S><S><R><L><V><V><Q><L><H><C><K><F><G><V><R><K><T><H><N><L><S><F><Q><D><C><E><S><L><Q><A><V><F><D><P><A><S><C><P><H><M><L><R><A><P><A><R><V><L><G><E><A><V><L><P><F><S><P><A><L><A><E><V><T><L><G><I><G><R><G><R><R><V><I><L><R><S><Y><H><E><E><E><A><D><S><T><A><K><A><M><V><T><E><M><C><L><G><E><E><D><F><Q><Q><L><Q><A><Q><E><G><V><A><I><T><F><C><L><K><E><F><R><G><L><L><S><F><A><E><S><A><N><L><N><L><S><I><H><F><D><A><P><G><R><P><A><I><F><T><I><K><D><S><L><L><D><G><H><F><V><L><A><T><L><S><D><T><D><S><H><S><Q><D><L><G><S><P><E><R><H><Q><P><V><P><Q><L><Q><A><H><S><T><P><H><P><D><D><F><A><N><D><D><I><D><S><Y><M><I><A><M><E><T><T><I><G><N><E><G><S><R><V><L><P><S><I><S><L><S><P><G><P><Q><P><P><K><S><P><G><P><H><S><E><E><E><D><E><A><E><P><S><T><V><P><G><T><P><P><P><K><K><F><R><S><L><F><F><G><S><I><L><A><P><V><R><S><P><Q><G><P><S><P><V><L><A><E><D><S><E><G><E><G>
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair. The 9-1-1 complex stimulates DNA polymerase beta. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks. RAD9A possesses 3'->5' double stranded DNA exonuclease activity.<BOP>
A0A096LP55
<M><G><L><E><D><E><Q><K><M><L><T><E><S><G><D><P><E><E><E><E><E><E><E><E><E><L><V><D><P><L><T><T><V><R><E><Q><C><E><Q><L><E><K><C><V><K><A><R><E><R><L><E><L><Y><D><E><H><V><S><S><R><S><H><T><E><E><D><C><T><E><E><L><F><D><F><L><H><A><K><D><H><C><V><A><H><K><L><F><N><N><L><K>
May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.<BOP>
P50539
<M><E><R><V><K><M><I><N><V><Q><R><L><L><E><A><A><E><F><L><E><R><R><E><R><E><C><E><H><G><Y><A><S><S><F><P><S><M><P><S><P><R><L><Q><H><S><K><P><P><R><R><L><S><R><A><Q><K><H><S><S><G><S><S><N><T><S><T><A><N><R><S><T><H><N><E><L><E><K><N><R><R><A><H><L><R><L><C><L><E><R><L><K><V><L><I><P><L><G><P><D><C><T><R><H><T><T><L><G><L><L><N><K><A><K><A><H><I><K><K><L><E><E><A><E><R><K><S><Q><H><Q><L><E><N><L><E><R><E><Q><R><F><L><K><W><R><L><E><Q><L><Q><G><P><Q><E><M><E><R><I><R><M><D><S><I><G><S><T><I><S><S><D><R><S><D><S><E><R><E><E><I><E><V><D><V><E><S><T><E><F><S><H><G><E><V><D><N><I><S><T><T><S><I><S><D><I><D><D><H><S><S><L><P><S><I><G><S><D><E><G><Y><S><S><A><S><V><K><L><S><F><T><S>
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.<BOP>
Q7Z418
<M><E><V><S><G><H><P><Q><A><R><R><C><C><P><E><A><L><G><K><L><F><P><G><L><C><F><L><C><F><L><V><T><Y><A><L><V><G><A><V><V><F><S><A><I><E><D><G><Q><V><L><V><A><A><D><D><G><E><F><E><K><F><L><E><E><L><C><R><I><L><N><C><S><E><T><V><V><E><D><R><K><Q><D><L><Q><G><H><L><Q><K><V><K><P><Q><W><F><N><R><T><T><H><W><S><F><L><S><S><L><F><F><C><C><T><V><F><S><T><V><G><Y><G><Y><I><Y><P><V><T><R><L><G><K><Y><L><C><M><L><Y><A><L><F><G><I><P><L><M><F><L><V><L><T><D><T><G><D><I><L><A><T><I><L><S><T><S><Y><N><R><F><R><K><F><P><F><F><T><R><P><L><L><S><K><W><C><P><K><S><L><F><K><K><K><P><D><P><K><P><A><D><E><A><V><P><Q><I><I><I><S><A><E><E><L><P><G><P><K><L><G><T><C><P><S><R><P><S><C><S><M><E><L><F><E><R><S><H><A><L><E><K><Q><N><T><L><Q><L><P><P><Q><A><M><E><R><S><N><S><C><P><E><L><V><L><G><R><L><S><Y><S><I><I><S><N><L><D><E><V><G><Q><Q><V><E><R><L><D><I><P><L><P><I><I><A><L><I><V><F><A><Y><I><S><C><A><A><A><I><L><P><F><W><E><T><Q><L><D><F><E><N><A><F><Y><F><C><F><V><T><L><T><T><I><G><F><G><D><T><V><L><E><H><P><N><F><F><L><F><F><S><I><Y><I><I><V><G><M><E><I><V><F><I><A><F><K><L><V><Q><N><R><L><I><D><I><Y><K><N><V><M><L><F><F><A><K><G><K><F><Y><H><L><V><K><K>
K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors. In thymocytes, conducts K(+) currents upon T cell receptor.<BOP>
P61236
<M><V><R><I><S><K><P><K><T><F><Q><A><Y><L><D><D><C><H><R><R><Y><S><C><A><H><C><R><A><H><L><A><N><H><D><D><L><I><S><K><S><F><Q><G><S><Q><G><R><A><Y><L><F><N><S><V><V><N><V><G><C><G><P><A><E><E><R><V><L><L><T><G><L><H><A><V><A><D><I><H><C><E><N><C><K><T><T><L><G><W><K><Y><E><Q><A><F><E><S><S><Q><K><Y><K><E><G><K><Y><I><I><E><L><N><H><M><I><K><D><N><G><W><D>
Involved in proliferation and apoptosis in myeloid precursor cells.<BOP>
Q86SG2
<M><D><F><I><S><I><Q><Q><L><V><S><G><E><R><V><E><G><K><V><L><G><F><G><H><G><V><P><D><P><G><A><W><P><S><D><W><R><R><G><P><Q><E><A><V><A><R><E><K><L><K><L><E><E><E><K><K><K><K><L><E><R><F><N><S><T><R><F><N><L><D><N><L><A><D><L><E><N><L><V><Q><R><R><K><K><R><L><R><H><R><V><P><P><R><K><P><E><P><L><V><K><P><Q><S><Q><A><Q><V><E><P><V><G><L><E><M><F><L><K><A><A><A><E><N><Q><E><Y><L><I><D><K><Y><L><T><D><G><G><D><P><N><A><H><D><K><L><H><R><T><A><L><H><W><A><C><L><K><G><H><S><Q><L><V><N><K><L><L><V><A><G><A><T><V><D><A><R><D><L><L><D><R><T><P><V><F><W><A><C><R><G><G><H><L><V><I><L><K><Q><L><L><N><Q><G><A><R><V><N><A><R><D><K><I><G><S><T><P><L><H><V><A><V><R><T><R><H><P><D><C><L><E><H><L><I><E><C><G><A><H><L><N><A><Q><D><K><E><G><D><T><A><L><H><E><A><V><R><H><G><S><Y><K><A><M><K><L><L><L><L><Y><G><A><E><L><G><V><R><N><A><A><S><V><T><P><V><Q><L><A><R><D><W><Q><R><G><I><R><E><A><L><Q><A><H><V><A><H><P><R><T><R><C>
May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.<BOP>
A6NMN3
<M><K><C><Y><F><T><D><H><R><G><E><Q><S><P><T><D><G><T><T><L><S><L><T><S><P><E><S><T><E><E><S><V><E><V><F><W><P><G><T><I><Q><R><E><G><S><S><P><R><P><G><P><A><I><P><R><E><E><G><L><Y><F><A><A><R><D><R><G><M><R><D><W><S><S><S><P><S><S><E><S><S><E><Y><Q><S><Y><S><Q><Y><Q><S><C><C><S><C><M><C><D><E><D><N><A><A><P><Q><S><V><C><A><F><Y><T><H><V><Q><T><V><R><G><V><A><V><A><W><E><T><E><A><G><F><E><P><V><T><R><K><P><R><I><H><E><A><Q><F><I><K><R><Q><R><W><N><G><S><S><F><E><M><A><S><N><T><D><M><R><W><D><L><E><A><C><K><S><N><C><S><P><E><P><E><D><I><D><L><L><E><C><C><L><Q><E><L><R><E><P><P><D><W><L><V><T><T><N><Y><G><V><R><C><V><A><C><C><R><V><L><P><S><L><D><A><L><L><E><H><A><Q><H><G><I><R><E><G><F><S><C><Q><I><F><F><E><E><M><L><E><R><R><R><A><Q><G><Q><A><H><D><Q><Q><L><E><E><E><Q><S><P><S><D><N><S><E><C><S><R><P><Q><G><E><V><L><S><A><Q><Q><Q><E><K><Q>
Plays a role in fertilization through the acrosome reaction.<BOP>
O00221
<M><N><Q><R><R><S><E><S><R><P><G><N><H><R><L><Q><A><Y><A><E><P><G><K><G><D><S><G><G><A><G><P><L><S><G><S><A><R><R><G><R><G><G><G><G><A><I><R><V><R><R><P><C><W><S><G><G><A><G><R><G><G><G><P><A><W><A><V><R><L><P><T><V><T><A><G><W><T><W><P><A><L><R><T><L><S><S><L><R><A><G><P><S><E><P><H><S><P><G><R><R><P><P><R><A><G><R><P><L><C><Q><A><D><P><Q><P><G><K><A><A><R><R><S><L><E><P><D><P><A><Q><T><G><P><R><P><A><R><A><A><G><M><S><E><A><R><K><G><P><D><E><A><E><E><S><Q><Y><D><S><G><I><E><S><L><R><S><L><R><S><L><P><E><S><T><S><A><P><A><S><G><P><S><D><G><S><P><Q><P><C><T><H><P><P><G><P><V><K><E><P><Q><E><K><E><D><A><D><G><E><R><A><D><S><T><Y><G><S><S><S><L><T><Y><T><L><S><L><L><G><G><P><E><A><E><D><P><A><P><R><L><P><L><P><H><V><G><A><L><S><P><Q><Q><L><E><A><L><T><Y><I><S><E><D><G><D><T><L><V><H><L><A><V><I><H><E><A><P><A><V><L><L><C><C><L><A><L><L><P><Q><E><V><L><D><I><Q><N><N><L><Y><Q><T><A><L><H><L><A><V><H><L><D><Q><P><G><A><V><R><A><L><V><L><K><G><A><S><R><A><L><Q><D><R><H><G><D><T><A><L><H><V><A><C><Q><R><Q><H><L><A><C><A><R><C><L><L><E><G><R><P><E><P><G><R><G><T><S><H><S><L><D><L><Q><L><Q><N><W><Q><G><L><A><C><L><H><I><A><T><L><Q><K><N><Q><P><L><M><E><L><L><L><R><N><G><A><D><I><D><V><Q><E><G><T><S><G><K><T><A><L><H><L><A><V><E><T><Q><E><R><G><L><V><Q><F><L><L><Q><A><G><A><Q><V><D><A><R><M><L><N><G><C><T><P><L><H><L><A><A><G><R><G><L><M><G><I><S><S><T><L><C><K><A><G><A><D><S><L><L><R><N><V><E><D><E><T><P><Q><D><L><T><E><E><S><L><V><L><L><P><F><D><D><L><K><I><S><G><K><L><L><L><C><T><D>
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.<BOP>
O43900
<M><F><A><R><G><S><R><R><R><R><S><G><R><A><P><P><E><A><E><D><P><D><R><G><Q><P><C><N><S><C><R><E><Q><C><P><G><F><L><L><H><G><W><R><K><I><C><Q><H><C><K><C><P><R><E><E><H><A><V><H><A><V><P><V><D><L><E><R><I><M><C><R><L><I><S><D><F><Q><R><H><S><I><S><D><D><D><S><G><C><A><S><E><E><Y><A><W><V><P><P><G><L><K><P><E><Q><V><Y><Q><F><F><S><C><L><P><E><D><K><V><P><Y><V><N><S><P><G><E><K><Y><R><I><K><Q><L><L><H><Q><L><P><P><H><D><S><E><A><Q><Y><C><T><A><L><E><E><E><E><K><K><E><L><R><A><F><S><Q><Q><R><K><R><E><N><L><G><R><G><I><V><R><I><F><P><V><T><I><T><G><A><I><C><E><E><C><G><K><Q><I><G><G><G><D><I><A><V><F><A><S><R><A><G><L><G><A><C><W><H><P><Q><C><F><V><C><T><T><C><Q><E><L><L><V><D><L><I><Y><F><Y><H><V><G><K><V><Y><C><G><R><H><H><A><E><C><L><R><P><R><C><Q><A><C><D><E><I><I><F><S><P><E><C><T><E><A><E><G><R><H><W><H><M><D><H><F><C><C><F><E><C><E><A><S><L><G><G><Q><R><Y><V><M><R><Q><S><R><P><H><C><C><A><C><Y><E><A><R><H><A><E><Y><C><D><G><C><G><E><H><I><G><L><D><Q><G><Q><M><A><Y><E><G><Q><H><W><H><A><S><D><R><C><F><C><C><S><R><C><G><R><A><L><L><G><R><P><F><L><P><R><R><G><L><I><F><C><S><R><A><C><S><L><G><S><E><P><T><A><P><G><P><S><R><R><S><W><S><A><G><P><V><T><A><P><L><A><A><S><T><A><S><F><S><A><V><K><G><A><S><E><T><T><T><K><G><T><S><T><E><L><A><P><A><T><G><P><E><E><P><S><R><F><L><R><G><A><P><H><R><H><S><M><P><E><L><G><L><R><S><V><P><E><P><P><P><E><S><P><G><Q><P><N><L><R><P><D><D><S><A><F><G><R><Q><S><T><P><R><V><S><F><R><D><P><L><V><S><E><G><G><P><R><R><T><L><S><A><P><P><A><Q><R><R><R><P><R><S><P><P><P><R><A><P><S><R><R><R><H><H><H><H><N><H><H><H><H><H><N><R><H><P><S><R><R><R><H><Y><Q><C><D><A><G><S><G><S><D><S><E><S><C><S><S><S><P><S><S><S><S><S><E><S><S><E><D><D><G><F><F><L><G><E><R><I><P><L><P><P><H><L><C><R><P><M><P><A><Q><D><T><A><M><E><T><F><N><S><P><S><L><S><L><P><R><D><S><R><A><G><M><P><R><Q><A><R><D><K><N><C><I><V><A>
Involved in the planar cell polarity. PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module. Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions. Involved in the organization of the basal body. Involved in cilia growth and positioning. Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase.<BOP>
Q9P2W7
<M><P><K><R><R><D><I><L><A><I><V><L><I><V><L><P><W><T><L><L><I><T><V><W><H><Q><S><T><L><A><P><L><L><A><V><H><K><D><E><G><S><D><P><R><R><E><T><P><P><G><A><D><P><R><E><Y><C><T><S><D><R><D><I><V><E><V><V><R><T><E><Y><V><Y><T><R><P><P><P><W><S><D><T><L><P><T><I><H><V><V><T><P><T><Y><S><R><P><V><Q><K><A><E><L><T><R><M><A><N><T><L><L><H><V><P><N><L><H><W><L><V><V><E><D><A><P><R><R><T><P><L><T><A><R><L><L><R><D><T><G><L><N><Y><T><H><L><H><V><E><T><P><R><N><Y><K><L><R><G><D><A><R><D><P><R><I><P><R><G><T><M><Q><R><N><L><A><L><R><W><L><R><E><T><F><P><R><N><S><S><Q><P><G><V><V><Y><F><A><D><D><D><N><T><Y><S><L><E><L><F><E><E><M><R><S><T><R><R><V><S><V><W><P><V><A><F><V><G><G><L><R><Y><E><A><P><R><V><N><G><A><G><K><V><V><G><W><K><T><V><F><D><P><H><R><P><F><A><I><D><M><A><G><F><A><V><N><L><R><L><I><L><Q><R><S><Q><A><Y><F><K><L><R><G><V><K><G><G><Y><Q><E><S><S><L><L><R><E><L><V><T><L><N><D><L><E><P><K><A><A><N><C><T><K><I><L><V><W><H><T><R><T><E><K><P><V><L><V><N><E><G><K><K><G><F><T><D><P><S><V><E><I>
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.<BOP>
P23280
<M><R><A><L><V><L><L><L><S><L><F><L><L><G><G><Q><A><Q><H><V><S><D><W><T><Y><S><E><G><A><L><D><E><A><H><W><P><Q><H><Y><P><A><C><G><G><Q><R><Q><S><P><I><N><L><Q><R><T><K><V><R><Y><N><P><S><L><K><G><L><N><M><T><G><Y><E><T><Q><A><G><E><F><P><M><V><N><N><G><H><T><V><Q><I><S><L><P><S><T><M><R><M><T><V><A><D><G><T><V><Y><I><A><Q><Q><M><H><F><H><W><G><G><A><S><S><E><I><S><G><S><E><H><T><V><D><G><I><R><H><V><I><E><I><H><I><V><H><Y><N><S><K><Y><K><S><Y><D><I><A><Q><D><A><P><D><G><L><A><V><L><A><A><F><V><E><V><K><N><Y><P><E><N><T><Y><Y><S><N><F><I><S><H><L><A><N><I><K><Y><P><G><Q><R><T><T><L><T><G><L><D><V><Q><D><M><L><P><R><N><L><Q><H><Y><Y><T><Y><H><G><S><L><T><T><P><P><C><T><E><N><V><H><W><F><V><L><A><D><F><V><K><L><S><R><T><Q><V><W><K><L><E><N><S><L><L><D><H><R><N><K><T><I><H><N><D><Y><R><R><T><Q><P><L><N><H><R><V><V><E><S><N><F><P><N><Q><E><Y><T><L><G><S><E><F><Q><F><Y><L><H><K><I><E><E><I><L><D><Y><L><R><R><A><L><N>
Reversible hydration of carbon dioxide. Its role in saliva is unknown.<BOP>
Q9BQK8
<M><N><Y><V><G><Q><L><A><E><T><V><F><G><T><V><K><E><L><Y><R><G><L><N><P><A><T><L><S><G><G><I><D><V><L><V><V><K><Q><V><D><G><S><F><R><C><S><P><F><H><V><R><F><G><K><L><G><V><L><R><S><R><E><K><V><V><D><I><E><L><N><G><E><P><V><D><L><H><M><K><L><G><D><S><G><E><A><F><F><V><Q><E><L><E><S><D><D><E><H><V><P><P><G><L><C><T><S><P><I><P><W><G><G><L><S><G><F><P><S><D><S><Q><L><G><T><A><S><E><P><E><G><L><V><M><A><G><T><A><S><T><G><R><R><K><R><R><R><R><R><K><P><K><Q><K><E><D><A><V><A><T><D><S><S><P><E><E><L><E><A><G><A><E><S><E><L><S><L><P><E><K><L><R><P><E><P><P><G><V><Q><L><E><E><K><S><S><L><Q><P><K><D><I><Y><P><Y><S><D><G><E><W><P><P><Q><A><S><L><S><A><G><E><L><T><S><P><K><S><D><S><E><L><E><V><R><T><P><E><P><S><P><L><R><A><E><S><H><M><Q><W><A><W><G><R><L><P><K><V><A><R><A><E><R><P><E><S><S><V><V><L><E><G><R><A><G><A><T><S><P><P><R><G><G><P><S><T><P><S><T><S><V><A><G><G><V><D><P><L><G><L><P><I><Q><Q><T><E><A><G><A><D><L><Q><P><D><T><E><D><P><T><L><V><G><P><P><L><H><T><P><E><T><E><E><S><K><T><Q><S><S><G><D><M><G><L><P><P><A><S><K><S><W><S><W><A><T><L><E><V><P><V><P><T><G><Q><P><E><R><V><S><R><G><K><G><S><P><K><R><S><Q><H><L><G><P><S><D><I><Y><L><D><D><L><P><S><L><D><S><E><N><A><A><L><Y><F><P><Q><S><D><S><G><L><G><A><R><R><W><S><E><P><S><S><Q><K><S><L><R><D><P><N><P><E><H><E><P><E><P><T><L><D><T><V><D><T><I><A><L><S><L><C><G><G><L><A><D><S><R><D><I><S><L><E><K><F><N><Q><H><S><V><S><Y><Q><D><L><T><K><N><P><G><L><L><D><D><P><N><L><V><V><K><I><N><G><K><H><Y><N><W><A><V><A><A><P><M><I><L><S><L><Q><A><F><Q><K><N><L><P><K><S><T><M><D><K><L><E><R><E><K><M><P><R><K><G><G><R><W><W><F><S><W><R><R><R><D><F><L><A><E><E><R><S><A><Q><K><E><K><T><A><A><K><E><Q><Q><G><E><K><T><E><V><L><S><S><D><D><D><A><P><D><S><P><V><I><L><E><I><P><S><L><P><P><S><T><P><P><S><T><P><T><Y><K><K><S><L><R><L><S><S><D><Q><I><R><R><L><N><L><Q><E><G><A><N><D><V><V><F><S><V><T><T><Q><Y><Q><G><T><C><R><C><K><A><T><I><Y><L><W><K><W><D><D><K><V><V><I><S><D><I><D><G><T><I><T><K><S><D><A><L><G><H><I><L><P><Q><L><G><K><D><W><T><H><Q><G><I><T><S><L><Y><H><K><I><Q><L><N><G><Y><K><F><L><Y><C><S><A><R><A><I><G><M><A><D><L><T><K><G><Y><L><Q><W><V><S><E><G><G><C><S><L><P><K><G><P><I><L><L><S><P><S><S><L><F><S><A><L><H><R><E><V><I><E><K><K><P><E><V><F><K><V><A><C><L><S><D><I><Q><Q><L><F><L><P><H><G><Q><P><F><Y><A><A><F><G><N><R><P><N><D><V><F><A><Y><R><Q><V><G><L><P><E><S><R><I><F><T><V><N><P><R><G><E><L><I><Q><E><L><I><K><N><H><K><S><T><Y><E><R><L><G><E><V><V><E><L><L><F><P><P><V><A><R><G><P><S><T><D><L><A><N><P><E><Y><S><N><F><C><Y><W><R><E><P><L><P><A><V><D><L><D><T><L><D>
Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism.<BOP>
Q8NHH9
<M><A><E><G><D><E><A><A><R><G><Q><Q><P><H><Q><G><L><W><R><R><R><R><T><S><D><P><S><A><A><V><N><H><V><S><S><T><T><S><L><G><E><N><Y><E><D><D><D><L><V><N><S><D><E><V><M><K><K><P><C><P><V><Q><I><V><L><A><H><E><D><D><H><N><F><E><L><D><E><E><A><L><E><Q><I><L><L><Q><E><H><I><R><D><L><N><I><V><V><V><S><V><A><G><A><F><R><K><G><K><S><F><L><L><D><F><M><L><R><Y><M><Y><N><K><D><S><Q><S><W><I><G><G><N><N><E><P><L><T><G><F><T><W><R><G><G><C><E><R><E><T><T><G><I><Q><V><W><N><E><V><F><V><I><D><R><P><N><G><T><K><V><A><V><L><L><M><D><T><Q><G><A><F><D><S><Q><S><T><I><K><D><C><A><T><V><F><A><L><S><T><M><T><S><S><V><Q><V><Y><N><L><S><Q><N><I><Q><E><D><D><L><Q><H><L><Q><L><F><T><E><Y><G><R><L><A><M><E><E><I><Y><Q><K><P><F><Q><T><L><M><F><L><I><R><D><W><S><Y><P><Y><E><H><S><Y><G><L><E><G><G><K><Q><F><L><E><K><R><L><Q><V><K><Q><N><Q><H><E><E><L><Q><N><V><R><K><H><I><H><N><C><F><S><N><L><G><C><F><L><L><P><H><P><G><L><K><V><A><T><N><P><S><F><D><G><R><L><K><D><I><D><E><D><F><K><R><E><L><R><N><L><V><P><L><L><L><A><P><E><N><L><V><E><K><E><I><S><G><S><K><V><T><C><R><D><L><V><E><Y><F><K><A><Y><I><K><I><Y><Q><G><E><E><L><P><H><P><K><S><M><L><Q><A><T><A><E><A><N><N><L><A><A><V><A><G><A><R><D><T><Y><C><K><S><M><E><Q><V><C><G><G><D><K><P><Y><I><A><P><S><D><L><E><R><K><H><L><D><L><K><E><V><A><I><K><Q><F><R><S><V><K><K><M><G><G><D><E><F><C><R><R><Y><Q><D><Q><L><E><A><E><I><E><E><T><Y><A><N><F><I><K><H><N><D><G><K><N><I><F><Y><A><A><R><T><P><A><T><L><F><A><V><M><F><A><M><Y><I><I><S><G><L><T><G><F><I><G><L><N><S><I><A><V><L><C><N><L><V><M><G><L><A><L><I><F><L><C><T><W><A><Y><V><K><Y><S><G><E><F><R><E><I><G><T><V><I><D><Q><I><A><E><T><L><W><E><Q><V><L><K><P><L><G><D><N><L><M><E><E><N><I><R><Q><S><V><T><N><S><I><K><A><G><L><T><D><Q><V><S><H><H><A><R><L><K><T><D>
GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.<BOP>
Q8N2S1
<M><P><R><P><G><T><S><G><R><R><P><L><L><L><V><L><L><L><P><L><F><A><A><A><T><S><A><A><S><P><S><P><S><P><S><Q><V><V><E><V><P><G><V><P><S><R><P><A><S><V><A><V><C><R><C><C><P><G><Q><T><S><R><R><S><R><C><I><R><A><F><C><R><V><R><S><C><Q><P><K><K><C><A><G><P><Q><R><C><L><N><P><V><P><A><V><P><S><P><S><P><S><V><R><K><R><Q><V><S><L><N><W><Q><P><L><T><L><Q><E><A><R><A><L><L><K><R><R><R><P><R><G><P><G><G><R><G><L><L><R><R><R><P><P><Q><R><A><P><A><G><K><A><P><V><L><C><P><L><I><C><H><N><G><G><V><C><V><K><P><D><R><C><L><C><P><P><D><F><A><G><K><F><C><Q><L><H><S><S><G><A><R><P><P><A><P><A><V><P><G><L><T><R><S><V><Y><T><M><P><L><A><N><H><R><D><D><E><H><G><V><A><S><M><V><S><V><H><V><E><H><P><Q><E><A><S><V><V><V><H><Q><V><E><R><V><S><G><P><W><E><E><A><D><A><E><A><V><A><R><A><E><A><A><A><R><A><E><A><A><A><P><Y><T><V><L><A><Q><S><A><P><R><E><D><G><Y><S><D><A><S><G><F><G><Y><C><F><R><E><L><R><G><G><E><C><A><S><P><L><P><G><L><R><T><Q><E><V><C><C><R><G><A><G><L><A><W><G><V><H><D><C><Q><L><C><S><E><R><L><G><N><S><E><R><V><S><A><P><D><G><P><C><P><T><G><F><E><R><V><N><G><S><C><E><D><V><D><E><C><A><T><G><G><R><C><Q><H><G><E><C><A><N><T><R><G><G><Y><T><C><V><C><P><D><G><F><L><L><D><S><S><R><S><S><C><I><S><Q><H><V><I><S><E><A><K><G><P><C><F><R><V><L><R><D><G><G><C><S><L><P><I><L><R><N><I><T><K><Q><I><C><C><C><S><R><V><G><K><A><W><G><R><G><C><Q><L><C><P><P><F><G><S><E><G><F><R><E><I><C><P><A><G><P><G><Y><H><Y><S><A><S><D><L><R><Y><N><T><R><P><L><G><Q><E><P><P><R><V><S><L><S><Q><P><R><T><L><P><A><T><S><R><P><S><A><G><F><L><P><T><H><R><L><E><P><R><P><E><P><R><P><D><P><R><P><G><P><E><L><P><L><P><S><I><P><A><W><T><G><P><E><I><P><E><S><G><P><S><S><G><M><C><Q><R><N><P><Q><V><C><G><P><G><R><C><I><S><R><P><S><G><Y><T><C><A><C><D><S><G><F><R><L><S><P><Q><G><T><R><C><I><D><V><D><E><C><R><R><V><P><P><P><C><A><P><G><R><C><E><N><S><P><G><S><F><R><C><V><C><G><P><G><F><R><A><G><P><R><A><A><E><C><L><D><V><D><E><C><H><R><V><P><P><P><C><D><L><G><R><C><E><N><T><P><G><S><F><L><C><V><C><P><A><G><Y><Q><A><A><P><H><G><A><S><C><Q><D><V><D><E><C><T><Q><S><P><G><L><C><G><R><G><A><C><K><N><L><P><G><S><F><R><C><V><C><P><A><G><F><R><G><S><A><C><E><E><D><V><D><E><C><A><Q><E><P><P><P><C><G><P><G><R><C><D><N><T><A><G><S><F><H><C><A><C><P><A><G><F><R><S><R><G><P><G><A><P><C><Q><D><V><D><E><C><A><R><S><P><P><P><C><T><Y><G><R><C><E><N><T><E><G><S><F><Q><C><V><C><P><M><G><F><Q><P><N><T><A><G><S><E><C><E><D><V><D><E><C><E><N><H><L><A><C><P><G><Q><E><C><V><N><S><P><G><S><F><Q><C><R><T><C><P><S><G><H><H><L><H><R><G><R><C><T><D><V><D><E><C><S><S><G><A><P><P><C><G><P><H><G><H><C><T><N><T><E><G><S><F><R><C><S><C><A><P><G><Y><R><A><P><S><G><R><P><G><P><C><A><D><V><N><E><C><L><E><G><D><F><C><F><P><H><G><E><C><L><N><T><D><G><S><F><A><C><T><C><A><P><G><Y><R><P><G><P><R><G><A><S><C><L><D><V><D><E><C><S><E><E><D><L><C><Q><S><G><I><C><T><N><T><D><G><S><F><E><C><I><C><P><P><G><H><R><A><G><P><D><L><A><S><C><L><D><V><D><E><C><R><E><R><G><P><A><L><C><G><S><Q><R><C><E><N><S><P><G><S><Y><R><C><V><R><D><C><D><P><G><Y><H><A><G><P><E><G><T><C><D><D><V><D><E><C><Q><E><Y><G><P><E><I><C><G><A><Q><R><C><E><N><T><P><G><S><Y><R><C><T><P><A><C><D><P><G><Y><Q><P><T><P><G><G><G><C><Q><D><V><D><E><C><R><N><R><S><F><C><G><A><H><A><V><C><Q><N><L><P><G><S><F><Q><C><L><C><D><Q><G><Y><E><G><A><R><D><G><R><H><C><V><D><V><N><E><C><E><T><L><Q><G><V><C><G><A><A><L><C><E><N><V><E><G><S><F><L><C><V><C><P><N><S><P><E><E><F><D><P><M><T><G><R><C><V><P><P><R><T><S><A><G><T><F><P><G><S><Q><P><Q><A><P><A><S><P><V><L><P><A><R><P><P><P><P><P><L><P><R><R><P><S><T><P><R><Q><G><P><V><G><S><G><R><R><E><C><Y><F><D><T><A><A><P><D><A><C><D><N><I><L><A><R><N><V><T><W><Q><E><C><C><C><T><V><G><E><G><W><G><S><G><C><R><I><Q><Q><C><P><G><T><E><T><A><E><Y><Q><S><L><C><P><H><G><R><G><Y><L><A><P><S><G><D><L><S><L><R><R><D><V><D><E><C><Q><L><F><R><D><Q><V><C><K><S><G><V><C><V><N><T><A><P><G><Y><S><C><Y><C><S><N><G><Y><Y><Y><H><T><Q><R><L><E><C><I><D><N><D><E><C><A><D><E><E><P><A><C><E><G><G><R><C><V><N><T><V><G><S><Y><H><C><T><C><E><P><P><L><V><L><D><G><S><Q><R><R><C><V><S><N><E><S><Q><S><L><D><D><N><L><G><V><C><W><Q><E><V><G><A><D><L><V><C><S><H><P><R><L><D><R><Q><A><T><Y><T><E><C><C><C><L><Y><G><E><A><W><G><M><D><C><A><L><C><P><A><Q><D><S><D><D><F><E><A><L><C><N><V><L><R><P><P><A><Y><S><P><P><R><P><G><G><F><G><L><P><Y><E><Y><G><P><D><L><G><P><P><Y><Q><G><L><P><Y><G><P><E><L><Y><P><P><P><A><L><P><Y><D><P><Y><P><P><P><P><G><P><F><A><R><R><E><A><P><Y><G><A><P><R><F><D><M><P><D><F><E><D><D><G><G><P><Y><G><E><S><E><A><P><A><P><P><G><P><G><T><R><W><P><Y><R><S><R><D><T><R><R><S><F><P><E><P><E><E><P><P><E><G><G><S><Y><A><G><S><L><A><E><P><Y><E><E><L><E><A><E><E><C><G><I><L><D><G><C><T><N><G><R><C><V><R><V><P><E><G><F><T><C><R><C><F><D><G><Y><R><L><D><M><T><R><M><A><C><V><D><I><N><E><C><D><E><A><E><A><A><S><P><L><C><V><N><A><R><C><L><N><T><D><G><S><F><R><C><I><C><R><P><G><F><A><P><T><H><Q><P><H><H><C><A><P><A><R><P><R><A>
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.<BOP>
P22455
<M><R><L><L><L><A><L><L><G><V><L><L><S><V><P><G><P><P><V><L><S><L><E><A><S><E><E><V><E><L><E><P><C><L><A><P><S><L><E><Q><Q><E><Q><E><L><T><V><A><L><G><Q><P><V><R><L><C><C><G><R><A><E><R><G><G><H><W><Y><K><E><G><S><R><L><A><P><A><G><R><V><R><G><W><R><G><R><L><E><I><A><S><F><L><P><E><D><A><G><R><Y><L><C><L><A><R><G><S><M><I><V><L><Q><N><L><T><L><I><T><G><D><S><L><T><S><S><N><D><D><E><D><P><K><S><H><R><D><P><S><N><R><H><S><Y><P><Q><Q><A><P><Y><W><T><H><P><Q><R><M><E><K><K><L><H><A><V><P><A><G><N><T><V><K><F><R><C><P><A><A><G><N><P><T><P><T><I><R><W><L><K><D><G><Q><A><F><H><G><E><N><R><I><G><G><I><R><L><R><H><Q><H><W><S><L><V><M><E><S><V><V><P><S><D><R><G><T><Y><T><C><L><V><E><N><A><V><G><S><I><R><Y><N><Y><L><L><D><V><L><E><R><S><P><H><R><P><I><L><Q><A><G><L><P><A><N><T><T><A><V><V><G><S><D><V><E><L><L><C><K><V><Y><S><D><A><Q><P><H><I><Q><W><L><K><H><I><V><I><N><G><S><S><F><G><A><D><G><F><P><Y><V><Q><V><L><K><T><A><D><I><N><S><S><E><V><E><V><L><Y><L><R><N><V><S><A><E><D><A><G><E><Y><T><C><L><A><G><N><S><I><G><L><S><Y><Q><S><A><W><L><T><V><L><P><E><E><D><P><T><W><T><A><A><A><P><E><A><R><Y><T><D><I><I><L><Y><A><S><G><S><L><A><L><A><V><L><L><L><L><A><G><L><Y><R><G><Q><A><L><H><G><R><H><P><R><P><P><A><T><V><Q><K><L><S><R><F><P><L><A><R><Q><F><S><L><E><S><G><S><S><G><K><S><S><S><S><L><V><R><G><V><R><L><S><S><S><G><P><A><L><L><A><G><L><V><S><L><D><L><P><L><D><P><L><W><E><F><P><R><D><R><L><V><L><G><K><P><L><G><E><G><C><F><G><Q><V><V><R><A><E><A><F><G><M><D><P><A><R><P><D><Q><A><S><T><V><A><V><K><M><L><K><D><N><A><S><D><K><D><L><A><D><L><V><S><E><M><E><V><M><K><L><I><G><R><H><K><N><I><I><N><L><L><G><V><C><T><Q><E><G><P><L><Y><V><I><V><E><C><A><A><K><G><N><L><R><E><F><L><R><A><R><R><P><P><G><P><D><L><S><P><D><G><P><R><S><S><E><G><P><L><S><F><P><V><L><V><S><C><A><Y><Q><V><A><R><G><M><Q><Y><L><E><S><R><K><C><I><H><R><D><L><A><A><R><N><V><L><V><T><E><D><N><V><M><K><I><A><D><F><G><L><A><R><G><V><H><H><I><D><Y><Y><K><K><T><S><N><G><R><L><P><V><K><W><M><A><P><E><A><L><F><D><R><V><Y><T><H><Q><S><D><V><W><S><F><G><I><L><L><W><E><I><F><T><L><G><G><S><P><Y><P><G><I><P><V><E><E><L><F><S><L><L><R><E><G><H><R><M><D><R><P><P><H><C><P><P><E><L><Y><G><L><M><R><E><C><W><H><A><A><P><S><Q><R><P><T><F><K><Q><L><V><E><A><L><D><K><V><L><L><A><V><S><E><E><Y><L><D><L><R><L><T><F><G><P><Y><S><P><S><G><G><D><A><S><S><T><C><S><S><S><D><S><V><F><S><H><D><P><L><P><L><G><S><S><S><F><P><F><G><S><G><V><Q><T>
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.<BOP>
Q6ZWL3
<M><A><G><L><W><L><G><L><V><W><Q><K><L><L><L><W><G><A><A><S><A><L><S><L><A><G><A><S><L><V><L><S><L><L><Q><R><V><A><S><Y><A><R><K><W><Q><Q><M><R><P><I><P><T><V><A><R><A><Y><P><L><V><G><H><A><L><L><M><K><P><D><G><R><E><F><F><Q><Q><I><I><E><Y><T><E><E><Y><R><H><M><P><L><L><K><L><W><V><G><P><V><P><M><V><A><L><Y><N><A><E><N><V><E><V><I><L><T><S><S><K><Q><I><D><K><S><S><M><Y><K><F><L><E><P><W><L><G><L><G><L><L><T><S><T><G><N><K><W><R><S><R><R><K><M><L><T><P><T><F><H><F><T><I><L><E><D><F><L><D><I><M><N><E><Q><A><N><I><L><V><K><K><L><E><K><H><I><N><Q><E><A><F><N><C><F><F><Y><I><T><L><C><A><L><D><I><I><C><E><T><A><M><G><K><N><I><G><A><Q><S><N><D><D><S><E><Y><V><R><A><V><Y><R><M><S><E><M><I><F><R><R><I><K><M><P><W><L><W><L><D><L><W><Y><L><M><F><K><E><G><W><E><H><K><K><S><L><Q><I><L><H><T><F><T><N><S><V><I><A><E><R><A><N><E><M><N><A><N><E><D><C><R><G><D><G><R><G><S><A><P><S><K><N><K><R><R><A><F><L><D><L><L><L><S><V><T><D><D><E><G><N><R><L><S><H><E><D><I><R><E><E><V><D><T><F><M><F><E><G><H><D><T><T><A><A><A><I><N><W><S><L><Y><L><L><G><S><N><P><E><V><Q><K><K><V><D><H><E><L><D><D><V><F><G><K><S><D><R><P><A><T><V><E><D><L><K><K><L><R><Y><L><E><C><V><I><K><E><T><L><R><L><F><P><S><V><P><L><F><A><R><S><V><S><E><D><C><E><V><A><G><Y><R><V><L><K><G><T><E><A><V><I><I><P><Y><A><L><H><R><D><P><R><Y><F><P><N><P><E><E><F><Q><P><E><R><F><F><P><E><N><A><Q><G><R><H><P><Y><A><Y><V><P><F><S><A><G><P><R><N><C><I><G><Q><K><F><A><V><M><E><E><K><T><I><L><S><C><I><L><R><H><F><W><I><E><S><N><Q><K><R><E><E><L><G><L><E><G><Q><L><I><L><R><P><S><N><G><I><W><I><K><L><K><R><R><N><A><D><E><R>
A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye. Catalyzes the omega-hydroxylation of polyunsaturated fatty acids. Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).<BOP>
A0A0A6YYK7
<M><L><T><A><S><L><L><R><A><V><I><A><S><I><C><V><V><S><S><M><A><Q><K><V><T><Q><A><Q><T><E><I><S><V><V><E><K><E><D><V><T><L><D><C><V><Y><E><T><R><D><T><T><Y><Y><L><F><W><Y><K><Q><P><P><S><G><E><L><V><F><L><I><R><R><N><S><F><D><E><Q><N><E><I><S><G><R><Y><S><W><N><F><Q><K><S><T><S><S><F><N><F><T><I><T><A><S><Q><V><V><D><S><A><V><Y><F><C><A><L><S><E>
V region of the variable domain of T cell receptor. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.<BOP>
Q8N4U5
<M><P><F><N><G><E><K><Q><C><V><G><E><D><Q><P><S><D><S><D><S><S><R><F><S><E><S><M><A><S><L><S><D><Y><E><C><S><R><Q><S><F><A><S><D><S><S><S><K><S><S><S><P><A><S><T><S><P><P><R><V><V><T><F><D><E><V><M><A><T><A><R><N><L><S><N><L><T><L><A><H><E><I><A><V><N><E><N><F><Q><L><K><Q><E><A><L><P><E><K><S><L><A><G><R><V><K><H><I><V><H><Q><A><F><W><D><V><L><D><S><E><L><N><A><D><P><P><E><F><E><H><A><I><K><L><F><E><E><I><R><E><I><L><L><S><F><L><T><P><G><G><N><R><L><R><N><Q><I><C><E><V><L><D><T><D><L><I><R><Q><Q><A><E><H><S><A><V><D><I><Q><G><L><A><N><Y><V><I><S><T><M><G><K><L><C><A><P><V><R><D><N><D><I><R><E><L><K><A><T><G><N><I><V><E><V><L><R><Q><I><F><H><V><L><D><L><M><Q><M><D><M><A><N><F><T><I><M><S><L><R><P><H><L><Q><R><Q><L><V><E><Y><E><R><T><K><F><Q><E><I><L><E><E><T><P><S><A><L><D><Q><T><T><E><W><I><K><E><S><V><N><E><E><L><F><S><L><S><E><S><A><L><T><P><G><A><E><N><T><S><K><P><S><L><S><P><T><L><V><L><N><N><S><Y><L><K><L><L><Q><W><D><Y><Q><K><K><E><L><P><E><T><L><M><T><D><G><A><R><L><Q><E><L><T><E><K><L><N><Q><L><K><I><I><A><C><L><S><L><I><T><N><N><M><V><G><A><I><T><G><G><L><P><E><L><A><S><R><L><T><R><I><S><A><V><L><L><E><G><M><N><K><E><T><F><N><L><K><E><V><L><N><S><I><G><I><Q><T><C><V><E><V><N><K><T><L><M><E><R><G><L><P><T><L><N><A><E><I><Q><A><N><L><I><G><Q><F><S><S><I><E><E><E><D><N><P><I><W><S><L><I><D><K><R><I><K><L><Y><M><R><R><L><L><C><L><P><S><P><Q><K><C><M><P><P><M><P><G><G><L><A><V><I><Q><Q><E><L><E><A><L><G><S><Q><Y><A><N><I><V><N><L><N><K><Q><V><Y><G><P><F><Y><A><N><I><L><R><K><L><L><F><N><E><E><A><M><G><K><V><D><A><S><P><P><T><N>
Promotes the migration of muscle-derived satellite cells (MDSCs) during differentiation throught interaction with FMNL2 and therefore may participate in microfilament assembly.<BOP>
Q9NPE2
<M><A><V><T><L><S><L><L><L><G><G><R><V><C><A><A><V><T><R><C><G><F><A><T><R><G><V><A><G><P><G><P><I><G><R><E><P><D><P><D><S><D><W><E><P><E><E><R><E><L><Q><E><V><E><S><T><L><K><R><Q><K><Q><A><I><R><F><Q><K><I><R><R><Q><M><E><A><P><G><A><P><P><R><T><L><T><W><E><A><M><E><Q><I><R><Y><L><H><E><E><F><P><E><S><W><S><V><P><R><L><A><E><G><F><D><V><S><T><D><V><I><R><R><V><L><K><S><K><F><L><P><T><L><E><Q><K><L><K><Q><D><Q><K><V><L><K><K><A><G><L><A><H><S><L><Q><H><L><R><G><S><G><N><T><S><K><L><L><P><A><G><H><S><V><S><G><S><L><L><M><P><G><H><E><A><S><S><K><D><P><N><H><S><T><A><L><K><V><I><E><S><D><T><H><R><T><N><T><P><R><R><R><K><G><R><N><K><E><I><Q><D><L><E><E><S><F><V><P><V><A><A><P><L><G><H><P><R><E><L><Q><K><Y><S><S><D><S><E><S><P><R><G><T><G><S><G><A><L><P><S><G><Q><K><L><E><E><L><K><A><E><E><P><D><N><F><S><S><K><V><V><Q><R><G><R><E><F><F><D><S><N><G><N><F><L><Y><R><I>
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.<BOP>
Q6L8G4
<M><G><C><C><G><C><S><G><G><C><G><S><G><C><G><G><C><G><S><G><S><G><G><C><G><S><G><C><G><G><C><G><S><S><C><C><V><P><I><C><C><C><K><P><V><C><C><C><V><P><A><C><S><C><S><S><C><G><S><C><G><G><S><K><G><G><C><G><S><C><G><S><S><K><G><G><C><G><S><C><G><C><S><Q><S><N><C><C><K><P><C><C><S><S><S><G><C><G><S><F><C><C><Q><S><S><C><S><K><P><C><C><C><Q><S><S><C><C><Q><S><S><C><C><K><P><C><C><C><Q><S><S><C><C><Q><S><S><C><F><K><P><C><C><C><Q><S><S><C><C><V><P><V><C><C><Q><C><K><I>
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.<BOP>
Q01658
<M><A><S><S><S><G><N><D><D><D><L><T><I><P><R><A><A><I><N><K><M><I><K><E><T><L><P><N><V><R><V><A><N><D><A><R><E><L><V><V><N><C><C><T><E><F><I><H><L><I><S><S><E><A><N><E><I><C><N><K><S><E><K><K><T><I><S><P><E><H><V><I><Q><A><L><E><S><L><G><F><G><S><Y><I><S><E><V><K><E><V><L><Q><E><C><K><T><V><A><L><K><R><R><K><A><S><S><R><L><E><N><L><G><I><P><E><E><E><L><L><R><Q><Q><Q><E><L><F><A><K><A><R><Q><Q><Q><A><E><L><A><Q><Q><E><W><L><Q><M><Q><Q><A><A><Q><Q><A><Q><L><A><A><A><S><A><S><A><S><N><Q><A><G><S><S><Q><D><E><E><D><D><D><D><I>
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.<BOP>
Q9UNY4
<M><E><E><V><R><C><P><E><H><G><T><F><C><F><L><K><T><G><V><R><D><G><P><N><K><G><K><S><F><Y><V><C><R><A><D><T><C><S><F><V><R><A><T><D><I><P><V><S><H><C><L><L><H><E><D><F><V><V><E><L><Q><G><L><L><L><P><Q><D><K><K><E><Y><R><L><F><F><R><C><I><R><S><K><A><E><G><K><R><W><C><G><S><I><P><W><Q><D><P><D><S><K><E><H><S><V><S><N><K><S><Q><H><A><S><E><T><F><H><H><S><S><N><W><L><R><N><P><F><K><V><L><D><K><N><Q><E><P><A><L><W><K><Q><L><I><K><G><E><G><E><E><K><K><A><D><K><K><Q><R><E><K><G><D><Q><L><F><D><Q><K><K><E><Q><K><P><E><M><M><E><K><D><L><S><S><G><L><V><P><K><K><K><Q><S><V><V><Q><E><K><K><Q><E><E><G><A><E><I><Q><C><E><A><E><T><G><G><T><H><K><R><D><F><S><E><I><K><S><Q><Q><C><Q><G><N><E><L><T><R><P><S><A><S><S><Q><E><K><S><S><G><K><S><Q><D><V><Q><R><E><S><E><P><L><R><E><K><V><T><Q><L><L><P><Q><N><V><H><S><H><N><S><I><S><K><P><Q><K><G><G><P><L><N><K><E><Y><T><N><W><E><A><K><E><T><K><A><K><D><G><P><S><I><Q><A><T><Q><K><S><L><P><Q><G><H><F><Q><E><R><P><E><T><H><S><V><P><A><P><G><G><P><A><A><Q><A><A><P><A><A><P><G><L><S><L><G><E><G><R><E><A><A><T><S><S><D><D><E><E><E><D><D><V><V><F><V><S><S><K><P><G><S><P><L><L><F><D><S><T><L><D><L><E><T><K><E><N><L><Q><F><P><D><R><S><V><Q><R><K><V><S><P><A><S><G><V><S><K><K><V><E><P><S><D><P><V><A><R><R><V><Y><L><T><T><Q><L><K><Q><K><K><S><T><L><A><S><V><N><I><Q><A><L><P><D><K><G><Q><K><L><I><K><Q><I><Q><E><L><E><E><V><L><S><G><L><T><L><S><P><E><Q><G><T><N><E><K><S><N><S><Q><V><P><Q><Q><S><H><F><T><K><T><T><T><G><P><P><H><L><V><P><P><Q><P><L><P><R><R><G><T><Q><P><V><G><S><L><E><L><K><S><A><C><Q><V><T><A><G><G><S><S><Q><C><Y><R><G><H><T><N><Q><D><H><V><H><A><V><W><K><I><T><S><E><A><I><G><Q><L><H><R><S><L><E><S><C><P><G><E><T><V><V><A><E><D><P><A><G><L><K><V><P><L><L><L><H><Q><K><Q><A><L><A><W><L><L><W><R><E><S><Q><K><P><Q><G><G><I><L><A><D><D><M><G><L><G><K><T><L><T><M><I><A><L><I><L><T><Q><K><N><Q><E><K><K><E><E><K><E><K><S><T><A><L><T><W><L><S><K><D><D><S><C><D><F><T><S><H><G><T><L><I><I><C><P><A><S><L><I><H><H><W><K><N><E><V><E><K><R><V><N><S><N><K><L><R><V><Y><L><Y><H><G><P><N><R><D><S><R><A><R><V><L><S><T><Y><D><I><V><I><T><T><Y><S><L><V><A><K><E><I><P><T><N><K><Q><E><A><E><I><P><G><A><N><L><N><V><E><G><T><S><T><P><L><L><R><I><A><W><A><R><I><I><L><D><E><A><H><N><V><K><N><P><R><V><Q><T><S><I><A><V><C><K><L><Q><A><C><A><R><W><A><V><T><G><T><P><I><Q><N><N><L><L><D><M><Y><S><L><L><K><F><L><R><C><S><P><F><D><E><F><N><L><W><R><S><Q><V><D><N><G><S><K><K><G><G><E><R><L><S><I><L><T><K><S><L><L><L><R><R><T><K><D><Q><L><D><S><T><G><R><P><L><V><I><L><P><Q><R><K><F><Q><L><H><H><L><K><L><S><E><D><E><E><T><V><Y><N><V><F><F><A><R><S><R><S><A><L><Q><S><Y><L><K><R><H><E><S><R><G><N><Q><S><G><R><S><P><N><N><P><F><S><R><V><A><L><E><F><G><S><E><E><P><R><H><S><E><A><A><D><S><P><R><S><S><T><V><H><I><L><S><Q><L><L><R><L><R><Q><C><C><C><H><L><S><L><L><K><S><A><L><D><P><M><E><L><K><G><E><G><L><V><L><S><L><E><E><Q><L><S><A><L><T><L><S><E><L><R><D><S><E><P><S><S><T><V><S><L><N><G><T><F><F><K><M><E><L><F><E><G><M><R><E><S><T><K><I><S><S><L><L><A><E><L><E><A><I><Q><R><N><S><A><S><Q><K><S><V><I><V><S><Q><W><T><N><M><L><K><V><V><A><L><H><L><K><K><H><G><L><T><Y><A><T><I><D><G><S><V><N><P><K><Q><R><M><D><L><V><E><A><F><N><H><S><R><G><P><Q><V><M><L><I><S><L><L><A><G><G><V><G><L><N><L><T><G><G><N><H><L><F><L><L><D><M><H><W><N><P><S><L><E><D><Q><A><C><D><R><I><Y><R><V><G><Q><Q><K><D><V><V><I><H><R><F><V><C><E><G><T><V><E><E><K><I><L><Q><L><Q><E><K><K><K><D><L><A><K><Q><V><L><S><G><S><G><E><S><V><T><K><L><T><L><A><D><L><R><V><L><F><G><I>
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.<BOP>
Q8IUI8
<M><R><G><A><M><E><L><E><P><E><L><L><L><Q><E><A><R><E><N><V><E><A><A><Q><S><Y><R><R><E><L><G><H><R><L><E><G><L><R><E><A><R><R><Q><I><K><E><S><A><S><Q><T><R><D><V><L><K><Q><H><F><N><D><L><K><G><T><L><G><K><L><L><D><E><R><L><V><T><L><L><Q><E><V><D><T><I><E><Q><E><T><I><K><P><L><D><D><C><Q><K><L><I><E><H><G><V><N><T><A><E><D><L><V><R><E><G><E><I><A><M><L><G><G><V><G><E><E><N><E><K><L><W><S><F><T><K><K><A><S><H><I><Q><L><D><S><L><P><E><V><P><L><L><V><D><V><P><C><L><S><A><Q><L><D><D><S><I><L><N><I><V><K><D><H><I><F><K><H><G><T><V><A><S><R><P><P><V><Q><I><E><E><L><I><E><K><P><G><G><I><I><V><R><W><C><K><V><D><D><D><F><T><A><Q><D><Y><R><L><Q><F><R><K><C><T><S><N><H><F><E><D><V><Y><V><G><S><E><T><E><F><I><V><L><H><I><D><P><N><V><D><Y><Q><F><R><V><C><A><R><G><D><G><R><Q><E><W><S><P><W><S><V><P><Q><I><G><H><S><T><L><V><P><H><E><W><T><A><G><F><E><G><Y><S><L><S><S><R><R><N><I><A><L><R><N><D><S><E><S><S><G><V><L><Y><S><R><A><P><T><Y><F><C><G><Q><T><L><T><F><R><V><E><T><V><G><Q><P><D><R><R><D><S><I><G><V><C><A><E><K><Q><D><G><Y><D><S><L><Q><R><D><Q><A><V><C><I><S><T><N><G><A><V><F><V><N><G><K><E><M><T><N><Q><L><P><A><V><T><S><G><S><T><V><T><F><D><I><E><A><V><T><L><G><T><T><S><N><N><E><G><G><H><F><K><L><R><V><T><I><S><S><N><N><R><E><V><V><F><D><W><L><L><D><Q><S><C><G><S><L><Y><F><G><C><S><F><F><Y><P><G><W><K><V><L><V><F>
May play a role in the negative regulation of cell cycle progression.<BOP>
Q7Z4Y8
<M><A><P><F><V><R><N><L><V><E><K><T><P><A><L><V><N><A><A><V><T><Y><L><K><P><R><L><A><A><F><W><Y><Y><T><T><V><E><L><V><P><P><T><P><A><E><I><P><R><A><I><Q><S><L><K><K><I><V><S><S><A><Q><T><G><S><F><K><Q><L><T><V><K><E><A><L><L><N><G><L><V><A><T><E><V><S><T><W><F><Y><V><R><E><I><T><G><K><R><G><I><I><G>
Mitochondrial membrane ATP synthase.<BOP>
Q9UQ05
<M><P><V><M><K><G><L><L><A><P><Q><N><T><F><L><D><T><I><A><T><R><F><D><G><T><H><S><N><F><L><L><A><N><A><Q><G><T><R><G><F><P><I><V><Y><C><S><D><G><F><C><E><L><T><G><Y><G><R><T><E><V><M><Q><K><T><C><S><C><R><F><L><Y><G><P><E><T><S><E><P><A><L><Q><R><L><H><K><A><L><E><G><H><Q><E><H><R><A><E><I><C><F><Y><R><K><D><G><S><A><F><W><C><L><L><D><M><M><P><I><K><N><E><M><G><E><V><V><L><F><L><F><S><F><K><D><I><T><Q><S><G><S><P><G><L><G><P><Q><G><G><R><G><D><S><N><H><E><N><S><L><G><R><R><G><A><T><W><K><F><R><S><A><R><R><R><S><R><T><V><L><H><R><L><T><G><H><F><G><R><R><G><Q><G><G><M><K><A><N><N><N><V><F><E><P><K><P><S><V><P><E><Y><K><V><A><S><V><G><G><S><R><C><L><L><L><H><Y><S><V><S><K><A><I><W><D><G><L><I><L><L><A><T><F><Y><V><A><V><T><V><P><Y><N><V><C><F><S><G><D><D><D><T><P><I><T><S><R><H><T><L><V><S><D><I><A><V><E><M><L><F><I><L><D><I><I><L><N><F><R><T><T><Y><V><S><Q><S><G><Q><V><I><S><A><P><R><S><I><G><L><H><Y><L><A><T><W><F><F><I><D><L><I><A><A><L><P><F><D><L><L><Y><I><F><N><I><T><V><T><S><L><V><H><L><L><K><T><V><R><L><L><R><L><L><R><L><L><Q><K><L><E><R><Y><S><Q><C><S><A><V><V><L><T><L><L><M><S><V><F><A><L><L><A><H><W><M><A><C><I><W><Y><V><I><G><R><R><E><M><E><A><N><D><P><L><L><W><D><I><G><W><L><H><E><L><G><K><R><L><E><V><P><Y><V><N><G><S><V><G><G><P><S><R><R><S><A><Y><I><A><A><L><Y><F><T><L><S><S><L><T><S><V><G><F><G><N><V><C><A><N><T><D><A><E><K><I><F><S><I><C><T><M><L><I><G><A><L><M><H><A><V><V><F><G><N><V><T><A><I><I><Q><R><M><Y><S><R><R><S><L><Y><H><S><R><M><K><D><L><K><D><F><I><R><V><H><R><L><P><R><P><L><K><Q><R><M><L><E><Y><F><Q><T><T><W><A><V><N><S><G><I><D><A><N><E><L><L><R><D><F><P><D><E><L><R><A><D><I><A><M><H><L><N><R><E><I><L><Q><L><P><L><F><G><A><A><S><R><G><C><L><R><A><L><S><L><H><I><K><T><S><F><C><A><P><G><E><Y><L><L><R><R><G><D><A><L><Q><A><H><Y><Y><V><C><S><G><S><L><E><V><L><R><D><N><M><V><L><A><I><L><G><K><G><D><L><I><G><A><D><I><P><E><P><G><Q><E><P><G><L><G><A><D><P><N><F><V><L><K><T><S><A><D><V><K><A><L><T><Y><C><G><L><Q><Q><L><S><S><R><G><L><A><E><V><L><R><L><Y><P><E><Y><G><A><A><F><R><A><G><L><P><R><D><L><T><F><N><L><R><Q><G><S><D><T><S><G><L><S><R><F><S><R><S><P><R><L><S><Q><P><R><S><E><S><L><G><S><S><S><D><K><T><L><P><S><I><T><E><A><E><S><G><A><E><P><G><G><G><P><R><P><R><R><P><L><L><L><P><N><L><S><P><A><R><P><R><G><S><L><V><S><L><L><G><E><E><L><P><P><F><S><A><L><V><S><S><P><S><L><S><P><S><L><S><P><A><L><A><G><Q><G><H><S><A><S><P><H><G><P><P><R><C><S><A><A><W><K><P><P><Q><L><L><I><P><P><L><G><T><F><G><P><P><D><L><S><P><R><I><V><D><G><I><E><D><S><G><S><T><A><E><A><P><S><F><R><F><S><R><R><P><E><L><P><R><P><R><S><Q><A><P><P><T><G><T><R><P><S><P><E><L><A><S><E><A><E><E><V><K><E><K><V><C><R><L><N><Q><E><I><S><R><L><N><Q><E><V><S><Q><L><S><R><E><L><R><H><I><M><G><L><L><Q><A><R><L><G><P><P><G><H><P><A><G><S><A><W><T><P><D><P><P><C><P><Q><L><R><P><P><C><L><S><P><C><A><S><R><P><P><P><S><L><Q><D><T><T><L><A><E><V><H><C><P><A><S><V><G><T><M><E><T><G><T><A><L><L><D><L><R><P><S><I><L><P><P><Y><P><S><E><P><D><P><L><G><P><S><P><V><P><E><A><S><P><P><T><P><S><L><L><R><H><S><F><Q><S><R><S><D><T><F><H>
Pore-forming.<BOP>
Q9H9G7
<M><E><I><G><S><A><G><P><A><G><A><Q><P><L><L><M><V><P><R><R><P><G><Y><G><T><M><G><K><P><I><K><L><L><A><N><C><F><Q><V><E><I><P><K><I><D><V><Y><L><Y><E><V><D><I><K><P><D><K><C><P><R><R><V><N><R><E><V><V><D><S><M><V><Q><H><F><K><V><T><I><F><G><D><R><R><P><V><Y><D><G><K><R><S><L><Y><T><A><N><P><L><P><V><A><T><T><G><V><D><L><D><V><T><L><P><G><E><G><G><K><D><R><P><F><K><V><S><I><K><F><V><S><R><V><S><W><H><L><L><H><E><V><L><T><G><R><T><L><P><E><P><L><E><L><D><K><P><I><S><T><N><P><V><H><A><V><D><V><V><L><R><H><L><P><S><M><K><Y><T><P><V><G><R><S><F><F><S><A><P><E><G><Y><D><H><P><L><G><G><G><R><E><V><W><F><G><F><H><Q><S><V><R><P><A><M><W><K><M><M><L><N><I><D><V><S><A><T><A><F><Y><K><A><Q><P><V><I><Q><F><M><C><E><V><L><D><I><H><N><I><D><E><Q><P><R><P><L><T><D><S><H><R><V><K><F><T><K><E><I><K><G><L><K><V><E><V><T><H><C><G><T><M><R><R><K><Y><R><V><C><N><V><T><R><R><P><A><S><H><Q><T><F><P><L><Q><L><E><N><G><Q><T><V><E><R><T><V><A><Q><Y><F><R><E><K><Y><T><L><Q><L><K><Y><P><H><L><P><C><L><Q><V><G><Q><E><Q><K><H><T><Y><L><P><L><E><V><C><N><I><V><A><G><Q><R><C><I><K><K><L><T><D><N><Q><T><S><T><M><I><K><A><T><A><R><S><A><P><D><R><Q><E><E><I><S><R><L><V><R><S><A><N><Y><E><T><D><P><F><V><Q><E><F><Q><F><K><V><R><D><E><M><A><H><V><T><G><R><V><L><P><A><P><M><L><Q><Y><G><G><R><N><R><T><V><A><T><P><S><H><G><V><W><D><M><R><G><K><Q><F><H><T><G><V><E><I><K><M><W><A><I><A><C><F><A><T><Q><R><Q><C><R><E><E><I><L><K><G><F><T><D><Q><L><R><K><I><S><K><D><A><G><M><P><I><Q><G><Q><P><C><F><C><K><Y><A><Q><G><A><D><S><V><E><P><M><F><R><H><L><K><N><T><Y><S><G><L><Q><L><I><I><V><I><L><P><G><K><T><P><V><Y><A><E><V><K><R><V><G><D><T><L><L><G><M><A><T><Q><C><V><Q><V><K><N><V><I><K><T><S><P><Q><T><L><S><N><L><C><L><K><I><N><V><K><L><G><G><I><N><N><I><L><V><P><H><Q><R><P><S><V><F><Q><Q><P><V><I><F><L><G><A><D><V><T><H><P><P><A><G><D><G><K><K><P><S><I><A><A><V><V><G><S><M><D><A><H><P><S><R><Y><C><A><T><V><R><V><Q><R><P><R><Q><E><I><I><Q><D><L><A><S><M><V><R><E><L><L><I><Q><F><Y><K><S><T><R><F><K><P><T><R><I><I><F><Y><R><D><G><V><S><E><G><Q><F><R><Q><V><L><Y><Y><E><L><L><A><I><R><E><A><C><I><S><L><E><K><D><Y><Q><P><G><I><T><Y><I><V><V><Q><K><R><H><H><T><R><L><F><C><A><D><R><T><E><R><V><G><R><S><G><N><I><P><A><G><T><T><V><D><T><D><I><T><H><P><Y><E><F><D><F><Y><L><C><S><H><A><G><I><Q><G><T><S><R><P><S><H><Y><H><V><L><W><D><D><N><C><F><T><A><D><E><L><Q><L><L><T><Y><Q><L><C><H><T><Y><V><R><C><T><R><S><V><S><I><P><A><P><A><Y><Y><A><H><L><V><A><F><R><A><R><Y><H><L><V><D><K><E><H><D><S><A><E><G><S><H><V><S><G><Q><S><N><G><R><D><P><Q><A><L><A><K><A><V><Q><I><H><Q><D><T><L><R><T><M><Y><F><A>
Required for RNA-mediated gene silencing.<BOP>
Q92538
<M><V><D><K><N><I><Y><I><I><Q><G><E><I><N><I><V><V><G><A><I><K><R><N><A><R><W><S><T><H><T><P><L><D><E><E><R><D><P><L><L><H><S><F><G><H><L><K><E><V><L><N><S><I><T><E><L><S><E><I><E><P><N><V><F><L><R><P><F><L><E><V><I><R><S><E><D><T><T><G><P><I><T><G><L><A><L><T><S><V><N><K><F><L><S><Y><A><L><I><D><P><T><H><E><G><T><A><E><G><M><E><N><M><A><D><A><V><T><H><A><R><F><V><G><T><D><P><A><S><D><E><V><V><L><M><K><I><L><Q><V><L><R><T><L><L><L><T><P><V><G><A><H><L><T><N><E><S><V><C><E><I><M><Q><S><C><F><R><I><C><F><E><M><R><L><S><E><L><L><R><K><S><A><E><H><T><L><V><D><M><V><Q><L><L><F><T><R><L><P><Q><F><K><E><E><P><K><N><Y><V><G><T><N><M><K><K><L><K><M><R><A><G><G><M><S><D><S><S><K><W><K><K><Q><K><R><S><P><R><P><P><R><H><M><T><K><V><T><P><G><S><E><L><P><T><P><N><G><T><T><L><S><S><N><L><T><G><G><M><P><F><I><D><V><P><T><P><I><S><S><A><S><S><E><A><A><S><A><V><V><S><P><S><T><D><S><G><L><E><F><S><S><Q><T><T><S><K><E><D><L><T><D><L><E><Q><P><G><S><P><G><Y><S><T><A><T><E><P><G><S><S><E><L><G><V><P><E><Q><P><D><L><Q><Q><E><G><T><H><V><E><K><S><Q><S><A><S><V><E><S><I><P><E><V><L><E><E><C><T><S><P><A><D><H><S><D><S><A><S><V><H><D><M><D><Y><V><N><P><R><G><V><R><F><T><Q><S><S><Q><K><E><G><T><A><L><V><P><Y><G><L><P><C><I><R><E><L><F><R><F><L><I><S><L><T><N><P><H><D><R><H><N><S><E><V><M><I><H><M><G><L><H><L><L><T><V><A><L><E><S><A><P><V><A><Q><C><Q><T><L><L><G><L><I><K><D><E><M><C><R><H><L><F><Q><L><L><S><I><E><R><L><N><L><Y><A><A><S><L><R><V><C><F><L><L><F><E><S><M><R><E><H><L><K><F><Q><M><E><M><Y><I><K><K><L><M><E><I><I><T><V><E><N><P><K><M><P><Y><E><M><K><E><M><A><L><E><A><I><V><Q><L><W><R><I><P><S><F><V><T><E><L><Y><I><N><Y><D><C><D><Y><Y><C><S><N><L><F><E><E><L><T><K><L><L><S><K><N><A><F><P><V><S><G><Q><L><Y><T><T><H><L><L><S><L><D><A><L><L><T><V><I><D><S><T><E><A><H><C><Q><A><K><V><L><N><S><L><T><Q><Q><E><K><K><E><T><A><R><P><S><C><E><I><V><D><G><T><R><E><A><S><N><T><E><R><T><A><S><D><G><K><A><V><G><M><A><S><D><I><P><G><L><H><L><P><G><G><G><R><L><P><P><E><H><G><K><S><G><C><S><D><L><E><E><A><V><D><S><G><A><D><K><K><F><A><R><K><P><P><R><F><S><C><L><L><P><D><P><R><E><L><I><E><I><K><N><K><K><K><L><L><I><T><G><T><E><Q><F><N><Q><K><P><K><K><G><I><Q><F><L><Q><E><K><G><L><L><T><I><P><M><D><N><T><E><V><A><Q><W><L><R><E><N><P><R><L><D><K><K><M><I><G><E><F><V><S><D><R><K><N><I><D><L><L><E><S><F><V><S><T><F><S><F><Q><G><L><R><L><D><E><A><L><R><L><Y><L><E><A><F><R><L><P><G><E><A><P><V><I><Q><R><L><L><E><A><F><T><E><R><W><M><N><C><N><G><S><P><F><A><N><S><D><A><C><F><S><L><A><Y><A><V><I><M><L><N><T><D><Q><H><N><H><N><V><R><K><Q><N><A><P><M><T><L><E><E><F><R><K><N><L><K><G><V><N><G><G><K><D><F><E><Q><D><I><L><E><D><M><Y><H><A><I><K><N><E><E><I><V><M><P><E><E><Q><T><G><L><V><R><E><N><Y><V><W><N><V><L><L><H><R><G><A><T><P><E><G><I><F><L><R><V><P><T><A><S><Y><D><L><D><L><F><T><M><T><W><G><P><T><I><A><A><L><S><Y><V><F><D><K><S><L><E><E><T><I><I><Q><K><A><I><S><G><F><R><K><C><A><M><I><S><A><H><Y><G><L><S><D><V><F><D><N><L><I><I><S><L><C><K><F><T><A><L><S><S><E><S><I><E><N><L><P><S><V><F><G><S><N><P><K><A><H><I><A><A><K><T><V><F><H><L><A><H><R><H><G><D><I><L><R><E><G><W><K><N><I><M><E><A><M><L><Q><L><F><R><A><Q><L><L><P><K><A><M><I><E><V><E><D><F><V><D><P><N><G><K><I><S><L><Q><R><E><E><T><P><S><N><R><G><E><S><T><V><L><S><F><V><S><W><L><T><L><S><G><P><E><Q><S><S><V><R><G><P><S><T><E><N><Q><E><A><K><R><V><A><L><E><C><I><K><Q><C><D><P><E><K><M><I><T><E><S><K><F><L><Q><L><E><S><L><Q><E><L><M><K><A><L><V><S><V><T><P><D><E><E><T><Y><D><E><E><D><A><A><F><C><L><E><M><L><L><R><I><V><L><E><N><R><D><R><V><G><C><V><W><Q><T><V><R><D><H><L><Y><H><L><C><V><Q><A><Q><D><F><C><F><L><V><E><R><A><V><V><G><L><L><R><L><A><I><R><L><L><R><R><E><E><I><S><A><Q><V><L><L><S><L><R><I><L><L><L><M><K><P><S><V><L><S><R><V><S><H><Q><V><A><Y><G><L><H><E><L><L><K><T><N><A><A><N><I><H><S><G><D><D><W><A><T><L><F><T><L><L><E><C><I><G><S><G><V><K><P><P><A><A><L><Q><A><T><A><R><A><D><A><P><D><A><G><A><Q><S><D><S><E><L><P><S><Y><H><Q><N><D><V><S><L><D><R><G><Y><T><S><D><S><E><V><Y><T><D><H><G><R><P><G><K><I><H><R><S><A><T><D><A><D><V><V><N><S><G><W><L><V><V><G><K><D><D><V><D><N><S><K><P><G><P><S><R><P><G><P><S><P><L><I><N><Q><Y><S><L><T><V><G><L><D><L><G><P><H><D><T><K><S><L><L><K><C><V><E><S><L><S><F><I><V><R><D><A><A><H><I><T><P><D><N><F><E><L><C><V><K><T><L><R><I><F><V><E><A><S><L><N><G><G><C><K><S><Q><E><K><R><G><K><S><H><K><Y><D><S><K><G><N><R><F><K><K><K><S><K><E><G><S><M><L><R><R><P><R><T><S><S><Q><H><A><S><R><G><G><Q><S><D><D><D><E><D><E><G><V><P><A><S><Y><H><T><V><S><L><Q><V><S><Q><D><L><L><D><L><M><H><T><L><H><T><R><A><A><S><I><Y><S><S><W><A><E><E><Q><R><H><L><E><T><G><G><Q><K><I><E><A><D><S><R><T><L><W><A><H><C><W><C><P><L><L><Q><G><I><A><C><L><C><C><D><A><R><R><Q><V><R><M><Q><A><L><T><Y><L><Q><R><A><L><L><V><H><D><L><Q><K><L><D><A><L><E><W><E><S><C><F><N><K><V><L><F><P><L><L><T><K><L><L><E><N><I><S><P><A><D><V><G><G><M><E><E><T><R><M><R><A><S><T><L><L><S><K><V><F><L><Q><H><L><S><P><L><L><S><L><S><T><F><A><A><L><W><L><T><I><L><D><F><M><D><K><Y><M><H><A><G><S><S><D><L><L><S><E><A><I><P><E><S><L><K><N><M><L><L><V><M><D><T><A><E><I><F><H><S><A><D><A><R><G><G><G><P><S><A><L><W><E><I><T><W><E><R><I><D><C><F><L><P><H><L><R><D><E><L><F><K><Q><T><V><I><Q><D><P><M><P><M><E><P><Q><G><Q><K><P><L><A><S><A><H><L><T><S><A><A><G><D><T><R><T><P><G><H><P><P><P><P><E><I><P><S><E><L><G><A><C><D><F><E><K><P><E><S><P><R><A><A><S><S><S><S><P><G><S><P><V><A><S><S><P><S><R><L><S><P><T><P><D><G><P><P><P><L><A><Q><P><P><L><I><L><Q><P><L><A><S><P><L><Q><V><G><V><P><P><M><T><L><P><I><I><L><N><P><A><L><I><E><A><T><S><P><V><P><L><L><A><T><P><R><P><T><D><P><I><P><T><S><E><V><N>
Guanine-nucleotide exchange factor. Involved in the processing of PSAP. Required for the assembly of the Golgi apparatus. The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions. May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate. In neutrophils, involved in G protein-coupled receptor. Plays a role in maintaining mitochondrial morphology.<BOP>
Q6IQ26
<M><S><G><G><G><G><G><G><G><S><A><P><S><R><F><A><D><Y><F><V><I><C><G><L><D><T><E><T><G><L><E><P><D><E><L><S><A><L><C><Q><Y><I><Q><A><S><K><A><R><D><G><A><S><P><F><I><S><S><T><T><E><G><E><N><F><E><Q><T><P><L><R><R><T><F><K><S><K><V><L><A><R><Y><P><E><N><V><E><W><N><P><F><D><Q><D><A><V><G><M><L><C><M><P><K><G><L><A><F><K><T><Q><A><D><P><R><E><P><Q><F><H><A><F><I><I><T><R><E><D><G><S><R><T><F><G><F><A><L><T><F><Y><E><E><V><T><S><K><Q><I><C><S><A><M><Q><T><L><Y><H><M><H><N><A><E><Y><D><V><L><H><A><P><P><A><D><D><R><D><Q><S><S><M><E><D><G><E><D><T><P><V><T><K><L><Q><R><F><N><S><Y><D><I><S><R><D><T><L><Y><V><S><K><C><I><C><L><I><T><P><M><S><F><M><K><A><C><R><S><V><L><E><Q><L><H><Q><A><V><T><S><P><Q><P><P><P><L><P><L><E><S><Y><I><Y><N><V><L><Y><E><V><P><L><P><P><P><G><R><S><L><K><F><S><G><V><Y><G><P><I><I><C><Q><R><P><S><T><N><E><L><P><L><F><D><F><P><V><K><E><V><F><E><L><L><G><V><E><N><V><F><Q><L><F><T><C><A><L><L><E><F><Q><I><L><L><Y><S><Q><H><Y><Q><R><L><M><T><V><A><E><T><I><T><A><L><M><F><P><F><Q><W><Q><H><V><Y><V><P><I><L><P><A><S><L><L><H><F><L><D><A><P><V><P><Y><L><M><G><L><H><S><N><G><L><D><D><R><S><K><L><E><L><P><Q><E><A><N><L><C><F><V><D><I><D><N><H><F><I><E><L><P><E><D><L><P><Q><F><P><N><K><L><E><F><V><Q><E><V><S><E><I><L><M><A><F><G><I><P><P><E><G><N><L><H><C><S><E><S><A><S><K><L><K><R><L><R><A><S><E><L><V><S><D><K><R><N><G><N><I><A><G><S><P><L><H><S><Y><E><L><L><K><E><N><E><T><I><A><R><L><Q><A><L><V><K><R><T><G><V><S><L><E><K><L><E><V><R><E><D><P><S><S><N><K><D><L><K><V><Q><C><D><E><E><E><L><R><I><Y><Q><L><N><I><Q><I><R><E><V><F><A><N><R><F><T><Q><M><F><A><D><Y><E><V><F><V><I><Q><P><S><Q><D><K><E><S><W><F><T><N><R><E><Q><M><Q><N><F><D><K><A><S><F><L><S><D><Q><P><E><P><Y><L><P><F><L><S><R><F><L><E><T><Q><M><F><A><S><F><I><D><N><K><I><M><C><H><D><D><D><D><K><D><P><V><L><R><V><F><D><S><R><V><D><K><I><R><L><L><N><V><R><T><P><T><L><R><T><S><M><Y><Q><K><C><T><T><V><D><E><A><E><K><A><I><E><L><R><L><A><K><I><D><H><T><A><I><H><P><H><L><L><D><M><K><I><G><Q><G><K><Y><E><P><G><F><F><P><K><L><Q><S><D><V><L><S><T><G><P><A><S><N><K><W><T><K><R><N><A><P><A><Q><W><R><R><K><D><R><Q><K><Q><H><T><E><H><L><R><L><D><N><D><Q><R><E><K><Y><I><Q><E><A><R><T><M><G><S><T><I><R><Q><P><K><L><S><N><L><S><P><S><V><I><A><Q><T><N><W><K><F><V><E><G><L><L><K><E><C><R><N><K><T><K><R><M><L><V><E><K><M><G><R><E><A><V><E><L><G><H><G><E><V><N><I><T><G><V><E><E><N><T><L><I><A><S><L><C><D><L><L><E><R><I><W><S><H><G><L><Q><V><K><Q><G><K><S><A><L><W><S><H><L><L><H><Y><Q><D><N><R><Q><R><K><L><T><S><G><S><L><S><T><S><G><I><L><L><D><S><E><R><R><K><S><D><A><S><S><L><M><P><P><L><R><I><S><L><I><Q><D><M><R><H><I><Q><N><I><G><E><I><K><T><D><V><G><K><A><R><A><W><V><R><L><S><M><E><K><K><L><L><S><R><H><L><K><Q><L><L><S><D><H><E><L><T><K><K><L><Y><K><R><Y><A><F><L><R><C><D><D><E><K><E><Q><F><L><Y><H><L><L><S><F><N><A><V><D><Y><F><C><F><T><N><V><F><T><T><I><L><I><P><Y><H><I><L><I><V><P><S><K><K><L><G><G><S><M><F><T><A><N><P><W><I><C><I><S><G><E><L><G><E><T><Q><I><M><Q><I><P><R><N><V><L><E><M><T><F><E><C><Q><N><L><G><K><L><T><T><V><Q><I><G><H><D><N><S><G><L><Y><A><K><W><L><V><E><Y><V><M><V><R><N><E><I><T><G><H><T><Y><K><F><P><C><G><R><W><L><G><K><G><M><D><D><G><S><L><E><R><I><L><V><G><E><L><L><T><S><Q><P><E><V><D><E><R><P><C><R><T><P><P><L><Q><Q><S><P><S><V><I><R><R><L><V><T><I><S><P><N><N><K><P><K><L><N><T><G><Q><I><Q><E><S><I><G><E><A><V><N><G><I><V><K><H><F><H><K><P><E><K><E><R><G><S><L><T><L><L><L><C><G><E><C><G><L><V><S><A><L><E><Q><A><F><Q><H><G><F><K><S><P><R><L><F><K><N><V><F><I><W><D><F><L><E><K><A><Q><T><Y><Y><E><T><L><E><K><N><E><V><V><P><E><E><N><W><H><T><R><A><R><N><F><C><R><F><V><T><A><I><N><N><T><P><R><N><I><G><K><D><G><K><F><Q><M><L><V><C><L><G><A><R><D><H><L><L><H><H><W><I><A><L><L><A><D><C><P><I><T><A><H><M><Y><E><D><V><A><L><I><K><D><H><T><L><V><N><S><L><I><R><V><L><Q><T><L><Q><E><F><N><I><T><L><E><T><S><L><V><K><G><I><D><I>
Guanine nucleotide exchange factor.<BOP>
O95800
<M><N><S><T><G><H><L><Q><D><A><P><N><A><T><S><L><H><V><P><H><S><Q><E><G><N><S><T><S><L><Q><E><G><L><Q><D><L><I><H><T><A><T><L><V><T><C><T><F><L><L><A><V><I><F><C><L><G><S><Y><G><N><F><I><V><F><L><S><F><F><D><P><A><F><R><K><F><R><T><N><F><D><F><M><I><L><N><L><S><F><C><D><L><F><I><C><G><V><T><A><P><M><F><T><F><V><L><F><F><S><S><A><S><S><I><P><D><A><F><C><F><T><F><H><L><T><S><S><G><F><I><I><M><S><L><K><T><V><A><V><I><A><L><H><R><L><R><M><V><L><G><K><Q><P><N><R><T><A><S><F><P><C><T><V><L><L><T><L><L><L><W><A><T><S><F><T><L><A><T><L><A><T><L><K><T><S><K><S><H><L><C><L><P><M><S><S><L><I><A><G><K><G><K><A><I><L><S><L><Y><V><V><D><F><T><F><C><V><A><V><V><S><V><S><Y><I><M><I><A><Q><T><L><R><K><N><A><Q><V><R><K><C><P><P><V><I><T><V><D><A><S><R><P><Q><P><F><M><G><V><P><V><Q><G><G><G><D><P><I><Q><C><A><M><P><A><L><Y><R><N><Q><N><Y><N><K><L><Q><H><V><Q><T><R><G><Y><T><K><S><P><N><Q><L><V><T><P><A><A><S><R><L><Q><L><V><S><A><I><N><L><S><T><A><K><D><S><K><A><V><V><T><C><V><I><I><V><L><S><V><L><V><C><C><L><P><L><G><I><S><L><V><Q><V><V><L><S><S><N><G><S><F><I><L><Y><Q><F><E><L><F><G><F><T><L><I><F><F><K><S><G><L><N><P><F><I><Y><S><R><N><S><A><G><L><R><R><K><V><L><W><C><L><Q><Y><I><G><L><G><F><F><C><C><K><Q><K><T><R><L><R><A><M><G><K><G><N><L><E><V><N><R><N><K><S><S><H><H><E><T><N><S><A><Y><M><L><S><P><K><P><Q><K><K><F><V><D><Q><A><C><G><P><S><H><S><K><E><S><M><V><S><P><K><I><S><A><G><H><Q><H><C><G><Q><S><S><S><T><P><I><N><T><R><I><E><P><Y><Y><S><I><Y><N><S><S><P><S><Q><E><E><S><S><P><C><N><L><Q><P><V><N><S><F><G><F><A><N><S><Y><I><A><M><H><Y><H><T><T><N><D><L><V><Q><E><Y><D><S><T><S><A><K><Q><I><P><V><P><S><V>
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.<BOP>
Q92633
<M><A><A><I><S><T><S><I><P><V><I><S><Q><P><Q><F><T><A><M><N><E><P><Q><C><F><Y><N><E><S><I><A><F><F><Y><N><R><S><G><K><H><L><A><T><E><W><N><T><V><S><K><L><V><M><G><L><G><I><T><V><C><I><F><I><M><L><A><N><L><L><V><M><V><A><I><Y><V><N><R><R><F><H><F><P><I><Y><Y><L><M><A><N><L><A><A><A><D><F><F><A><G><L><A><Y><F><Y><L><M><F><N><T><G><P><N><T><R><R><L><T><V><S><T><W><L><L><R><Q><G><L><I><D><T><S><L><T><A><S><V><A><N><L><L><A><I><A><I><E><R><H><I><T><V><F><R><M><Q><L><H><T><R><M><S><N><R><R><V><V><V><V><I><V><V><I><W><T><M><A><I><V><M><G><A><I><P><S><V><G><W><N><C><I><C><D><I><E><N><C><S><N><M><A><P><L><Y><S><D><S><Y><L><V><F><W><A><I><F><N><L><V><T><F><V><V><M><V><V><L><Y><A><H><I><F><G><Y><V><R><Q><R><T><M><R><M><S><R><H><S><S><G><P><R><R><N><R><D><T><M><M><S><L><L><K><T><V><V><I><V><L><G><A><F><I><I><C><W><T><P><G><L><V><L><L><L><L><D><V><C><C><P><Q><C><D><V><L><A><Y><E><K><F><F><L><L><L><A><E><F><N><S><A><M><N><P><I><I><Y><S><Y><R><D><K><E><M><S><A><T><F><R><Q><I><L><C><C><Q><R><S><E><N><P><T><G><P><T><E><G><S><D><R><S><A><S><S><L><N><H><T><I><L><A><G><V><H><S><N><D><H><S><V><V>
Receptor for lysophosphatidic acid. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation.<BOP>
D6R9N7
<M><E><D><D><S><L><Y><L><G><G><E><W><Q><F><N><H><F><S><K><L><T><S><S><R><P><D><A><A><F><A><E><I><Q><R><T><S><L><P><E><K><S><P><L><S><C><E><T><R><V><D><L><C><D><D><L><A><P><V><A><R><Q><L><A><P><R><E><K><L><P><L><S><S><R><R><P><A><A><V><G><A><G><L><Q><N><M><G><N><T><C><Y><V><N><A><S><L><Q><C><L><T><Y><T><P><P><L><A><N><Y><M><L><S><R><E><H><S><Q><T><C><H><R><H><K><G><C><M><L><C><T><M><Q><A><H><I><T><R><A><L><H><N><P><G><H><V><I><Q><P><S><Q><A><L><A><A><G><F><H><R><G><K><Q><E><D><A><H><E><F><L><M><F><T><V><D><A><M><K><K><A><C><L><P><G><H><K><Q><V><D><H><H><S><K><D><T><T><L><I><H><Q><I><F><G><G><Y><W><R><S><Q><I><K><C><L><H><C><H><G><I><S><D><T><F><D><P><Y><L><D><I><A><L><D><I><Q><A><A><Q><S><V><Q><Q><A><L><E><Q><L><V><K><P><E><E><L><N><G><E><N><A><Y><H><C><G><V><C><L><Q><R><A><P><A><S><K><T><L><T><L><H><T><S><A><K><V><L><I><L><V><L><K><R><F><S><D><V><T><G><N><K><I><A><K><N><V><Q><Y><P><E><C><L><D><M><Q><P><Y><M><S><Q><T><N><T><G><P><L><V><Y><V><L><Y><A><V><L><V><H><A><G><W><S><C><H><N><G><H><Y><F><S><Y><V><K><A><Q><E><G><Q><W><Y><K><M><D><D><A><E><V><T><A><S><S><I><T><S><V><L><S><Q><Q><A><Y><V><L><F><Y><I><Q><K><S><E><W><E><R><H><S><E><S><V><S><R><G><R><E><P><R><A><L><G><A><E><D><T><D><R><R><A><K><Q><G><E><L><K><R><D><H><P><C><L><Q><A><P><E><L><D><E><H><L><V><E><R><A><T><Q><E><S><T><L><D><H><W><K><F><L><Q><E><Q><N><K><T><K><P><E><F><N><V><R><K><V><E><G><T><L><P><P><D><V><L><V><I><H><Q><S><K><Y><K><C><G><M><K><N><H><H><P><E><Q><Q><S><S><L><L><N><L><S><S><T><T><P><T><H><Q><E><S><M><N><T><G><T><L><A><S><L><R><G><R><A><R><R><S><K><G><K><N><K><H><S><K><R><A><L><L><V><C><Q>
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.<BOP>
O43402
<M><P><G><V><K><L><T><T><Q><A><Y><C><K><M><V><L><H><G><A><K><Y><P><H><C><A><V><N><G><L><L><V><A><E><K><Q><K><P><R><K><E><H><L><P><L><G><G><P><G><A><H><H><T><L><F><V><D><C><I><P><L><F><H><G><T><L><A><L><A><P><M><L><E><V><A><L><T><L><I><D><S><W><C><K><D><H><S><Y><V><I><A><G><Y><Y><Q><A><N><E><R><V><K><D><A><S><P><N><Q><V><A><E><K><V><A><S><R><I><A><E><G><F><S><D><T><A><L><I><M><V><D><N><T><K><F><T><M><D><C><V><A><P><T><I><H><V><Y><E><H><H><E><N><R><W><R><C><R><D><P><H><H><D><Y><C><E><D><W><P><E><A><Q><R><I><S><A><S><L><L><D><S><R><S><Y><E><T><L><V><D><F><D><N><H><L><D><D><I><R><N><D><W><T><N><P><E><I><N><K><A><V><L><H><L><C>
Part of the endoplasmic reticulum membrane protein complex. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).<BOP>
P15173
<M><E><L><Y><E><T><S><P><Y><F><Y><Q><E><P><R><F><Y><D><G><E><N><Y><L><P><V><H><L><Q><G><F><E><P><P><G><Y><E><R><T><E><L><T><L><S><P><E><A><P><G><P><L><E><D><K><G><L><G><T><P><E><H><C><P><G><Q><C><L><P><W><A><C><K><V><C><K><R><K><S><V><S><V><D><R><R><R><A><A><T><L><R><E><K><R><R><L><K><K><V><N><E><A><F><E><A><L><K><R><S><T><L><L><N><P><N><Q><R><L><P><K><V><E><I><L><R><S><A><I><Q><Y><I><E><R><L><Q><A><L><L><S><S><L><N><Q><E><E><R><D><L><R><Y><R><G><G><G><G><P><Q><P><G><V><P><S><E><C><S><S><H><S><A><S><C><S><P><E><W><G><S><A><L><E><F><S><A><N><P><G><D><H><L><L><T><A><D><P><T><D><A><H><N><L><H><S><L><T><S><I><V><D><S><I><T><V><E><D><V><S><V><A><F><P><D><E><T><M><P><N>
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing.<BOP>
P02765
<M><K><S><L><V><L><L><L><C><L><A><Q><L><W><G><C><H><S><A><P><H><G><P><G><L><I><Y><R><Q><P><N><C><D><D><P><E><T><E><E><A><A><L><V><A><I><D><Y><I><N><Q><N><L><P><W><G><Y><K><H><T><L><N><Q><I><D><E><V><K><V><W><P><Q><Q><P><S><G><E><L><F><E><I><E><I><D><T><L><E><T><T><C><H><V><L><D><P><T><P><V><A><R><C><S><V><R><Q><L><K><E><H><A><V><E><G><D><C><D><F><Q><L><L><K><L><D><G><K><F><S><V><V><Y><A><K><C><D><S><S><P><D><S><A><E><D><V><R><K><V><C><Q><D><C><P><L><L><A><P><L><N><D><T><R><V><V><H><A><A><K><A><A><L><A><A><F><N><A><Q><N><N><G><S><N><F><Q><L><E><E><I><S><R><A><Q><L><V><P><L><P><P><S><T><Y><V><E><F><T><V><S><G><T><D><C><V><A><K><E><A><T><E><A><A><K><C><N><L><L><A><E><K><Q><Y><G><F><C><K><A><T><L><S><E><K><L><G><G><A><E><V><A><V><T><C><M><V><F><Q><T><Q><P><V><S><S><Q><P><Q><P><E><G><A><N><E><A><V><P><T><P><V><V><D><P><D><A><P><P><S><P><P><L><G><A><P><G><L><P><P><A><G><S><P><P><D><S><H><V><L><L><A><A><P><P><G><H><Q><L><H><R><A><H><Y><D><L><R><H><T><F><M><G><V><V><S><L><G><S><P><S><G><E><V><S><H><P><R><K><T><R><T><V><V><Q><P><S><V><G><A><A><A><G><P><V><V><P><P><C><P><G><R><I><R><H><F><K><V>
Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.<BOP>
Q12837
<M><M><M><M><S><L><N><S><K><Q><A><F><S><M><P><H><G><G><S><L><H><V><E><P><K><Y><S><A><L><H><S><T><S><P><G><S><S><A><P><I><A><P><S><A><S><S><P><S><S><S><S><N><A><G><G><G><G><G><G><G><G><G><G><G><G><G><G><G><R><S><S><S><S><S><S><S><G><S><S><G><G><G><G><S><E><A><M><R><R><A><C><L><P><T><P><P><S><N><I><F><G><G><L><D><E><S><L><L><A><R><A><E><A><L><A><A><V><D><I><V><S><Q><S><K><S><H><H><H><H><P><P><H><H><S><P><F><K><P><D><A><T><Y><H><T><M><N><T><I><P><C><T><S><A><A><S><S><S><S><V><P><I><S><H><P><S><A><L><A><G><T><H><H><H><H><H><H><H><H><H><H><H><H><Q><P><H><Q><A><L><E><G><E><L><L><E><H><L><S><P><G><L><A><L><G><A><M><A><G><P><D><G><A><V><V><S><T><P><A><H><A><P><H><M><A><T><M><N><P><M><H><Q><A><A><L><S><M><A><H><A><H><G><L><P><S><H><M><G><C><M><S><D><V><D><A><D><P><R><D><L><E><A><F><A><E><R><F><K><Q><R><R><I><K><L><G><V><T><Q><A><D><V><G><S><A><L><A><N><L><K><I><P><G><V><G><S><L><S><Q><S><T><I><C><R><F><E><S><L><T><L><S><H><N><N><M><I><A><L><K><P><I><L><Q><A><W><L><E><E><A><E><K><S><H><R><E><K><L><T><K><P><E><L><F><N><G><A><E><K><K><R><K><R><T><S><I><A><A><P><E><K><R><S><L><E><A><Y><F><A><I><Q><P><R><P><S><S><E><K><I><A><A><I><A><E><K><L><D><L><K><K><N><V><V><R><V><W><F><C><N><Q><R><Q><K><Q><K><R><M><K><Y><S><A><G><I>
Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells.<BOP>
P22234
<M><A><T><A><E><V><L><N><I><G><K><K><L><Y><E><G><K><T><K><E><V><Y><E><L><L><D><S><P><G><K><V><L><L><Q><S><K><D><Q><I><T><A><G><N><A><A><R><K><N><H><L><E><G><K><A><A><I><S><N><K><I><T><S><C><I><F><Q><L><L><Q><E><A><G><I><K><T><A><F><T><R><K><C><G><E><T><A><F><I><A><P><Q><C><E><M><I><P><I><E><W><V><C><R><R><I><A><T><G><S><F><L><K><R><N><P><G><V><K><E><G><Y><K><F><Y><P><P><K><V><E><L><F><F><K><D><D><A><N><N><D><P><Q><W><S><E><E><Q><L><I><A><A><K><F><C><F><A><G><L><L><I><G><Q><T><E><V><D><I><M><S><H><A><T><Q><A><I><F><E><I><L><E><K><S><W><L><P><Q><N><C><T><L><V><D><M><K><I><E><F><G><V><D><V><T><T><K><E><I><V><L><A><D><V><I><D><N><D><S><W><R><L><W><P><S><G><D><R><S><Q><Q><K><D><K><Q><S><Y><R><D><L><K><E><V><T><P><E><G><L><Q><M><V><K><K><N><F><E><W><V><A><E><R><V><E><L><L><L><K><S><E><S><Q><C><R><V><V><V><L><M><G><S><T><S><D><L><G><H><C><E><K><I><K><K><A><C><G><N><F><G><I><P><C><E><L><R><V><T><S><A><H><K><G><P><D><E><T><L><R><I><K><A><E><Y><E><G><D><G><I><P><T><V><F><V><A><V><A><G><R><S><N><G><L><G><P><V><M><S><G><N><T><A><Y><P><V><I><S><C><P><P><L><T><P><D><W><G><V><Q><D><V><W><S><S><L><R><L><P><S><G><L><G><C><S><T><V><L><S><P><E><G><S><A><Q><F><A><A><Q><I><F><G><L><S><N><H><L><V><W><S><K><L><R><A><S><I><L><N><T><W><I><S><L><K><Q><A><D><K><K><I><R><E><C><N><L>
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway.<BOP>
P24385
<M><E><H><Q><L><L><C><C><E><V><E><T><I><R><R><A><Y><P><D><A><N><L><L><N><D><R><V><L><R><A><M><L><K><A><E><E><T><C><A><P><S><V><S><Y><F><K><C><V><Q><K><E><V><L><P><S><M><R><K><I><V><A><T><W><M><L><E><V><C><E><E><Q><K><C><E><E><E><V><F><P><L><A><M><N><Y><L><D><R><F><L><S><L><E><P><V><K><K><S><R><L><Q><L><L><G><A><T><C><M><F><V><A><S><K><M><K><E><T><I><P><L><T><A><E><K><L><C><I><Y><T><D><N><S><I><R><P><E><E><L><L><Q><M><E><L><L><L><V><N><K><L><K><W><N><L><A><A><M><T><P><H><D><F><I><E><H><F><L><S><K><M><P><E><A><E><E><N><K><Q><I><I><R><K><H><A><Q><T><F><V><A><L><C><A><T><D><V><K><F><I><S><N><P><P><S><M><V><A><A><G><S><V><V><A><A><V><Q><G><L><N><L><R><S><P><N><N><F><L><S><Y><Y><R><L><T><R><F><L><S><R><V><I><K><C><D><P><D><C><L><R><A><C><Q><E><Q><I><E><A><L><L><E><S><S><L><R><Q><A><Q><Q><N><M><D><P><K><A><A><E><E><E><E><E><E><E><E><E><V><D><L><A><C><T><P><T><D><V><R><D><V><D><I>
Regulatory component of the cyclin D1-CDK4. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.<BOP>
Q8NB78
<M><A><T><P><R><G><R><T><K><K><K><A><S><F><D><H><S><P><D><S><L><P><L><R><S><S><G><R><Q><A><K><K><K><A><T><E><T><T><D><E><D><E><D><G><G><S><E><K><K><Y><R><K><C><E><K><A><G><C><T><A><T><C><P><V><C><F><A><S><A><S><E><R><C><A><K><N><G><Y><T><S><R><W><Y><H><L><S><C><G><E><H><F><C><N><E><C><F><D><H><Y><Y><R><S><H><K><D><G><Y><D><K><Y><T><T><W><K><K><I><W><T><S><N><G><K><T><E><P><S><P><K><A><F><M><A><D><Q><Q><L><P><Y><W><V><Q><C><T><K><P><E><C><R><K><W><R><Q><L><T><K><E><I><Q><L><T><P><Q><I><A><K><T><Y><R><C><G><M><K><P><N><T><A><I><K><P><E><T><S><D><H><C><S><L><P><E><D><L><R><V><L><E><V><S><N><H><W><W><Y><S><M><L><I><L><P><P><L><L><K><D><S><V><A><A><P><L><L><S><A><Y><Y><P><D><C><V><G><M><S><P><S><C><T><S><T><N><R><A><A><A><T><G><N><A><S><P><G><K><L><E><H><S><K><A><A><L><S><V><H><V><P><G><M><N><R><Y><F><Q><P><F><Y><Q><P><N><E><C><G><K><A><L><C><V><R><P><D><V><M><E><L><D><E><L><Y><E><F><P><E><Y><S><R><D><P><T><M><Y><L><A><L><R><N><L><I><L><A><L><W><Y><T><N><C><K><E><A><L><T><P><Q><K><C><I><P><H><I><I><V><R><G><L><V><R><I><R><C><V><Q><E><V><E><R><I><L><Y><F><M><T><R><K><G><L><I><N><T><G><V><L><S><V><G><A><D><Q><Y><L><L><P><K><D><Y><H><N><K><S><V><I><I><I><G><A><G><P><A><G><L><A><A><A><R><Q><L><H><N><F><G><I><K><V><T><V><L><E><A><K><D><R><I><G><G><R><V><W><D><D><K><S><F><K><G><V><T><V><G><R><G><A><Q><I><V><N><G><C><I><N><N><P><V><A><L><M><C><E><Q><L><G><I><S><M><H><K><F><G><E><R><C><D><L><I><Q><E><G><G><R><I><T><D><P><T><I><D><K><R><M><D><F><H><F><N><A><L><L><D><V><V><S><E><W><R><K><D><K><T><Q><L><Q><D><V><P><L><G><E><K><I><E><E><I><Y><K><A><F><I><K><E><S><G><I><Q><F><S><E><L><E><G><Q><V><L><Q><F><H><L><S><N><L><E><Y><A><C><G><S><N><L><H><Q><V><S><A><R><S><W><D><H><N><E><F><F><A><Q><F><A><G><D><H><T><L><L><T><P><G><Y><S><V><I><I><E><K><L><A><E><G><L><D><I><Q><L><K><S><P><V><Q><C><I><D><Y><S><G><D><E><V><Q><V><T><T><T><D><G><T><G><Y><S><A><Q><K><V><L><V><T><V><P><L><A><L><L><Q><K><G><A><I><Q><F><N><P><P><L><S><E><K><K><M><K><A><I><N><S><L><G><A><G><I><I><E><K><I><A><L><Q><F><P><Y><R><F><W><D><S><K><V><Q><G><A><D><F><F><G><H><V><P><P><S><A><S><K><R><G><L><F><A><V><F><Y><D><M><D><P><Q><K><K><H><S><V><L><M><S><V><I><A><G><E><A><V><A><S><V><R><T><L><D><D><K><Q><V><L><Q><Q><C><M><A><T><L><R><E><L><F><K><E><Q><E><V><P><D><P><T><K><Y><F><V><T><R><W><S><T><D><P><W><I><Q><M><A><Y><S><F><V><K><T><G><G><S><G><E><A><Y><D><I><I><A><E><D><I><Q><G><T><V><F><F><A><G><E><A><T><N><R><H><F><P><Q><T><V><T><G><A><Y><L><S><G><V><R><E><A><S><K><I><A><A><F>
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes.<BOP>
O75506
<M><A><E><T><D><P><K><T><V><Q><D><L><T><S><V><V><Q><T><L><L><Q><Q><M><Q><D><K><F><Q><T><M><S><D><Q><I><I><G><R><I><D><D><M><S><S><R><I><D><D><L><E><K><N><I><A><D><L><M><T><Q><A><G><V><E><E><L><E><S><E><N><K><I><P><A><T><Q><K><S>
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.<BOP>
Q7Z7C8
<M><A><D><A><A><A><T><A><G><A><G><G><S><G><T><R><S><G><S><K><Q><S><T><N><P><A><D><N><Y><H><L><A><R><R><R><T><L><Q><V><V><V><S><S><L><L><T><E><A><G><F><E><S><A><E><K><A><S><V><E><T><L><T><E><M><L><Q><S><Y><I><S><E><I><G><R><S><A><K><S><Y><C><E><H><T><A><R><T><Q><P><T><L><S><D><I><V><V><T><L><V><E><M><G><F><N><V><D><T><L><P><A><Y><A><K><R><S><Q><R><M><V><I><T><A><P><P><V><T><N><Q><P><V><T><P><K><A><L><T><A><G><Q><N><R><P><H><P><P><H><I><P><S><H><F><P><E><F><P><D><P><H><T><Y><I><K><T><P><T><Y><R><E><P><V><S><D><Y><Q><V><L><R><E><K><A><A><S><Q><R><R><D><V><E><R><A><L><T><R><F><M><A><K><T><G><E><T><Q><S><L><F><K><D><D><V><S><T><F><P><L><I><A><A><R><P><F><T><I><P><Y><L><T><A><L><L><P><S><E><L><E><M><Q><Q><M><E><E><T><D><S><S><E><Q><D><E><Q><T><D><T><E><N><L><A><L><H><I><S><M><E><D><S><G><A><E><K><E><N><T><S><V><L><Q><Q><N><P><S><L><S><G><S><R><N><G><E><E><N><I><I><D><N><P><Y><L><R><P><V><K><K><P><K><I><R><R><K><K><S><L><S>
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II.<BOP>
Q14642
<M><A><G><K><A><A><A><P><G><T><A><V><L><L><V><T><A><N><V><G><S><L><F><D><D><P><E><N><L><Q><K><N><W><L><R><E><F><Y><Q><V><V><H><T><H><K><P><H><F><M><A><L><H><C><Q><E><F><G><G><K><N><Y><E><A><S><M><S><H><V><D><K><F><V><K><E><L><L><S><S><D><A><M><K><E><Y><N><R><A><R><V><Y><L><D><E><N><Y><K><S><Q><E><H><F><T><A><L><G><S><F><Y><F><L><H><E><S><L><K><N><I><Y><Q><F><D><F><K><A><K><K><Y><R><K><V><A><G><K><E><I><Y><S><D><T><L><E><S><T><P><M><L><E><K><E><K><F><P><Q><D><Y><F><P><E><C><K><W><S><R><K><G><F><I><R><T><R><W><C><I><A><D><C><A><F><D><L><V><N><I><H><L><F><H><D><A><S><N><L><V><A><W><E><T><S><P><S><V><Y><S><G><I><R><H><K><A><L><G><Y><V><L><D><R><I><I><D><Q><R><F><E><K><V><S><Y><F><V><F><G><D><F><N><F><R><L><D><S><K><S><V><V><E><T><L><C><T><K><A><T><M><Q><T><V><R><A><A><D><T><N><E><V><V><K><L><I><F><R><E><S><D><N><D><R><K><V><M><L><Q><L><E><K><K><L><F><D><Y><F><N><Q><E><V><F><R><D><N><N><G><T><A><L><L><E><F><D><K><E><L><S><V><F><K><D><R><L><Y><E><L><D><I><S><F><P><P><S><Y><P><Y><S><E><D><A><R><Q><G><E><Q><Y><M><N><T><R><C><P><A><W><C><D><R><I><L><M><S><P><S><A><K><E><L><V><L><R><S><E><S><E><E><K><V><V><T><Y><D><H><I><G><P><N><V><C><M><G><D><H><K><P><V><F><L><A><F><R><I><M><P><G><A><G><K><P><H><A><H><V><H><K><C><C><V><V><Q>
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.<BOP>
Q15542
<M><A><A><L><A><E><E><Q><T><E><V><A><V><K><L><E><P><E><G><P><P><T><L><L><P><P><Q><A><G><D><G><A><G><E><G><S><G><G><T><T><N><N><G><P><N><G><G><G><G><N><V><A><A><S><S><S><T><G><G><D><G><G><T><P><K><P><T><V><A><V><S><A><A><A><P><A><G><A><A><P><V><P><A><A><A><P><D><A><G><A><P><H><D><R><Q><T><L><L><A><V><L><Q><F><L><R><Q><S><K><L><R><E><A><E><E><A><L><R><R><E><A><G><L><L><E><E><A><V><A><G><S><G><A><P><G><E><V><D><S><A><G><A><E><V><T><S><A><L><L><S><R><V><T><A><S><A><P><G><P><A><A><P><D><P><P><G><T><G><A><S><G><A><T><V><V><S><G><S><A><S><G><P><A><A><P><G><K><V><G><S><V><A><V><E><D><Q><P><D><V><S><A><V><L><S><A><Y><N><Q><Q><G><D><P><T><M><Y><E><E><Y><Y><S><G><L><K><H><F><I><E><C><S><L><D><C><H><R><A><E><L><S><Q><L><F><Y><P><L><F><V><H><M><Y><L><E><L><V><Y><N><Q><H><E><N><E><A><K><S><F><F><E><K><F><H><G><D><Q><E><C><Y><Y><Q><D><D><L><R><V><L><S><S><L><T><K><K><E><H><M><K><G><N><E><T><M><L><D><F><R><T><S><K><F><V><L><R><I><S><R><D><S><Y><Q><L><L><K><R><H><L><Q><E><K><Q><N><N><Q><I><W><N><I><V><Q><E><H><L><Y><I><D><I><F><D><G><M><P><R><S><K><Q><Q><I><D><A><M><V><G><S><L><A><G><E><A><K><R><E><A><N><K><S><K><V><F><F><G><L><L><K><E><P><E><I><E><V><P><L><D><D><E><D><E><E><G><E><N><E><E><G><K><P><K><K><K><K><P><K><K><D><S><I><G><S><K><S><K><K><Q><D><P><N><A><P><P><Q><N><R><I><P><L><P><E><L><K><D><S><D><K><L><D><K><I><M><N><M><K><E><T><T><K><R><V><R><L><G><P><D><C><L><P><S><I><C><F><Y><T><F><L><N><A><Y><Q><G><L><T><A><V><D><V><T><D><D><S><S><L><I><A><G><G><F><A><D><S><T><V><R><V><W><S><V><T><P><K><K><L><R><S><V><K><Q><A><S><D><L><S><L><I><D><K><E><S><D><D><V><L><E><R><I><M><D><E><K><T><A><S><E><L><K><I><L><Y><G><H><S><G><P><V><Y><G><A><S><F><S><P><D><R><N><Y><L><L><S><S><S><E><D><G><T><V><R><L><W><S><L><Q><T><F><T><C><L><V><G><Y><K><G><H><N><Y><P><V><W><D><T><Q><F><S><P><Y><G><Y><Y><F><V><S><G><G><H><D><R><V><A><R><L><W><A><T><D><H><Y><Q><P><L><R><I><F><A><G><H><L><A><D><V><N><C><T><R><F><H><P><N><S><N><Y><V><A><T><G><S><A><D><R><T><V><R><L><W><D><V><L><N><G><N><C><V><R><I><F><T><G><H><K><G><P><I><H><S><L><T><F><S><P><N><G><R><F><L><A><T><G><A><T><D><G><R><V><L><L><W><D><I><G><H><G><L><M><V><G><E><L><K><G><H><T><D><T><V><C><S><L><R><F><S><R><D><G><E><I><L><A><S><G><S><M><D><N><T><V><R><L><W><D><A><I><K><A><F><E><D><L><E><T><D><D><F><T><T><A><T><G><H><I><N><L><P><E><N><S><Q><E><L><L><L><G><T><Y><M><T><K><S><T><P><V><V><H><L><H><F><T><R><R><N><L><V><L><A><A><G><A><Y><S><P><Q>
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex. The TFIID complex consists of TBP and TBP-associated factors. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF5 is involved in two modules of TFIID, in TFIID-A together with TAF3 and TBP, and in TFIID-B with TAF8. Involved in contacts between TFIID and TFIIF in the PIC.<BOP>
Q8IYD8
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><I><L><P><D><D><S><S><E><E><E><N><N><V><N><D><K><R><E><S><N><I><A><V><N><P><S><T><V><K><K><N><K><Q><Q><D><H><C><L><N><S><V><P><S><G><S><S><A><Q><S><K><V><R><S><T><P><R><V><N><P><L><A><K><Q><S><K><Q><T><S><L><N><L><K><D><T><I><S><E><V><S><D><F><K><P><Q><N><H><N><E><V><Q><S><T><T><P><P><F><T><T><V><D><S><Q><K><D><C><R><K><F><P><V><P><Q><K><D><G><S><A><L><E><D><S><S><T><S><G><A><S><C><S><K><S><R><P><H><L><A><G><T><H><T><S><L><R><L><P><Q><E><G><K><G><T><C><I><L><V><G><G><H><E><I><T><S><G><L><E><V><I><S><S><L><R><A><I><H><G><L><Q><V><E><V><C><P><L><N><G><C><D><Y><I><V><S><N><R><M><V><V><E><R><R><S><Q><S><E><M><L><N><S><V><N><K><N><K><F><I><E><Q><I><Q><H><L><Q><S><M><F><E><R><I><C><V><I><V><E><K><D><R><E><K><T><G><D><T><S><R><M><F><R><R><T><K><S><Y><D><S><L><L><T><T><L><I><G><A><G><I><R><I><L><F><S><S><C><Q><E><E><T><A><D><L><L><K><E><L><S><L><V><E><Q><R><K><N><V><G><I><H><V><P><T><V><V><N><S><N><K><S><E><A><L><Q><F><Y><L><S><I><P><N><I><S><Y><I><T><A><L><N><M><C><H><Q><F><S><S><V><K><R><M><A><N><S><S><L><Q><E><I><S><M><Y><A><Q><V><T><H><Q><K><A><E><E><I><Y><R><Y><I><H><Y><V><F><D><I><Q><M><L><P><N><D><L><N><Q><D><R><L><K><S><D><I>
DNA-dependent ATPase component of the Fanconi anemia. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA.<BOP>
P50583
<M><A><L><R><A><C><G><L><I><I><F><R><R><C><L><I><P><K><V><D><N><N><A><I><E><F><L><L><L><Q><A><S><D><G><I><H><H><W><T><P><P><K><G><H><V><E><P><G><E><D><D><L><E><T><A><L><R><E><T><Q><E><E><A><G><I><E><A><G><Q><L><T><I><I><E><G><F><K><R><E><L><N><Y><V><A><R><N><K><P><K><T><V><I><Y><W><L><A><E><V><K><D><Y><D><V><E><I><R><L><S><H><E><H><Q><A><Y><R><W><L><G><L><E><E><A><C><Q><L><A><Q><F><K><E><M><K><A><A><L><Q><E><G><H><Q><F><L><C><S><I><E><A>
Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate. Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro.<BOP>
Q7Z4K8
<M><A><E><G><E><D><M><Q><T><F><T><S><I><M><D><A><L><V><R><I><S><T><S><M><K><N><M><E><K><E><L><L><C><P><V><C><Q><E><M><Y><K><Q><P><L><V><L><P><C><T><H><N><V><C><Q><A><C><A><R><E><V><L><G><Q><Q><G><Y><I><G><H><G><G><D><P><S><S><E><P><T><S><P><A><S><T><P><S><T><R><S><P><R><L><S><R><R><T><L><P><K><P><D><R><L><D><R><L><L><K><S><G><F><G><T><Y><P><G><R><K><R><G><A><L><H><P><Q><V><I><M><F><P><C><P><A><C><Q><G><D><V><E><L><G><E><R><G><L><A><G><L><F><R><N><L><T><L><E><R><V><V><E><R><Y><R><Q><S><V><S><V><G><G><A><I><L><C><Q><L><C><K><P><P><P><L><E><A><T><K><G><C><T><E><C><R><A><T><F><C><N><E><C><F><K><L><F><H><P><W><G><T><Q><K><A><Q><H><E><P><T><L><P><T><L><S><F><R><P><K><G><L><M><C><P><D><H><K><E><E><V><T><H><Y><C><K><T><C><Q><R><L><V><C><Q><L><C><R><V><R><R><T><H><S><G><H><K><I><T><P><V><L><S><A><Y><Q><A><L><K><D><K><L><T><K><S><L><T><Y><I><L><G><N><Q><D><T><V><Q><T><Q><I><C><E><L><E><E><A><V><R><H><T><E><V><S><G><Q><Q><A><K><E><E><V><S><Q><L><V><R><G><L><G><A><V><L><E><E><K><R><A><S><L><L><Q><A><I><E><E><C><Q><Q><E><R><L><A><R><L><S><A><Q><I><Q><E><H><R><S><L><L><D><G><S><G><L><V><G><Y><A><Q><E><V><L><K><E><T><D><Q><P><C><F><V><Q><A><A><K><Q><L><H><N><R><I><A><R><A><T><E><A><L><Q><T><F><R><P><A><A><S><S><S><F><R><H><C><Q><L><D><V><G><R><E><M><K><L><L><T><E><L><N><F><L><R><V><P><E><A><P><V><I><D><T><Q><R><T><F><A><Y><D><Q><I><F><L><C><W><R><L><P><P><H><S><P><P><A><W><H><Y><T><V><E><F><R><R><T><D><V><P><A><Q><P><G><P><T><R><W><Q><R><R><E><E><V><R><G><T><S><A><L><L><E><N><P><D><T><G><S><V><Y><V><L><R><V><R><G><C><N><K><A><G><Y><G><E><Y><S><E><D><V><H><L><H><T><P><P><A><P><V><L><H><F><F><L><D><S><R><W><G><A><S><R><E><R><L><A><I><S><K><D><Q><R><A><V><R><S><V><P><G><L><P><L><L><L><A><A><D><R><L><L><T><G><C><H><L><S><V><D><V><V><L><G><D><V><A><V><T><Q><G><R><S><Y><W><A><C><A><V><D><P><A><S><Y><L><V><K><V><G><V><G><L><E><S><K><L><Q><E><S><F><Q><G><A><P><D><V><I><S><P><R><Y><D><P><D><S><G><H><D><S><G><A><E><D><A><T><V><E><A><S><P><P><F><A><F><L><T><I><G><M><G><K><I><L><L><G><S><G><A><S><S><N><A><G><L><T><G><R><D><G><P><T><A><G><C><T><V><P><L><P><P><R><L><G><I><C><L><D><Y><E><R><G><R><V><S><F><L><D><A><V><S><F><R><G><L><L><E><C><P><L><D><C><S><G><P><V><C><P><A><F><C><F><I><G><G><G><A><V><Q><L><Q><E><P><V><G><T><K><P><E><R><K><V><T><I><G><G><F><A><K><L><D>
Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.<BOP>
Q96Q91
<M><E><M><K><L><P><G><Q><E><G><F><E><A><S><S><A><P><R><N><I><P><S><G><E><L><D><S><N><P><D><P><G><T><G><P><S><P><D><G><P><S><D><T><E><S><K><E><L><G><V><P><K><D><P><L><L><F><I><Q><L><N><E><L><L><G><W><P><Q><A><L><E><W><R><E><T><G><S><S><S><A><S><L><L><L><D><M><G><E><M><P><S><I><T><L><S><T><H><L><H><H><R><W><V><L><F><E><E><K><L><E><V><A><A><G><R><W><S><A><P><H><V><P><T><L><A><L><P><S><L><Q><K><L><R><S><L><L><A><E><G><L><V><L><L><D><C><P><A><Q><S><L><L><E><L><V><E><Q><V><T><R><V><E><S><L><S><P><E><L><R><G><Q><L><Q><A><L><L><L><Q><R><P><Q><H><Y><N><Q><T><T><G><T><R><P><C><W><G><S><T><H><P><R><K><A><S><D><N><E><E><A><P><L><R><E><Q><C><Q><N><P><L><R><Q><K><L><P><P><G><A><E><A><G><T><V><L><A><G><E><L><G><F><L><A><Q><P><L><G><A><F><V><R><L><R><N><P><V><V><L><G><S><L><T><E><V><S><L><P><S><R><F><F><C><L><L><L><G><P><C><M><L><G><K><G><Y><H><E><M><G><R><A><A><A><V><L><L><S><D><P><Q><F><Q><W><S><V><R><R><A><S><N><L><H><D><L><L><A><A><L><D><A><F><L><E><E><V><T><V><L><P><P><G><R><W><D><P><T><A><R><I><P><P><P><K><C><L><P><S><Q><H><K><R><L><P><S><Q><Q><R><E><I><R><G><P><A><V><P><R><L><T><S><A><E><D><R><H><R><H><G><P><H><A><H><S><P><E><L><Q><R><T><G><R><L><F><G><G><L><I><Q><D><V><R><R><K><V><P><W><Y><P><S><D><F><L><D><A><L><H><L><Q><C><F><S><A><V><L><Y><I><Y><L><A><T><V><T><N><A><I><T><F><G><G><L><L><G><D><A><T><D><G><A><Q><G><V><L><E><S><F><L><G><T><A><V><A><G><A><A><F><C><L><M><A><G><Q><P><L><T><I><L><S><S><T><G><P><V><L><V><F><E><R><L><L><F><S><F><S><R><D><Y><S><L><D><Y><L><P><F><R><L><W><V><G><I><W><V><A><T><F><C><L><V><L><V><A><T><E><A><S><V><L><V><R><Y><F><T><R><F><T><E><E><G><F><C><A><L><I><S><L><I><F><I><Y><D><A><V><G><K><M><L><N><L><T><H><T><Y><P><I><Q><K><P><G><S><S><A><Y><G><C><L><C><Q><Y><P><G><P><G><G><N><E><S><Q><W><I><R><T><R><P><K><D><R><D><D><I><V><S><M><D><L><G><L><I><N><A><S><L><L><P><P><P><E><C><T><R><Q><G><G><H><P><R><G><P><G><C><H><T><V><P><D><I><A><F><F><S><L><L><L><F><L><T><S><F><F><F><A><M><A><L><K><C><V><K><T><S><R><F><F><P><S><V><V><R><K><G><L><S><D><F><S><S><V><L><A><I><L><L><G><C><G><L><D><A><F><L><G><L><A><T><P><K><L><M><V><P><R><E><F><K><P><T><L><P><G><R><G><W><L><V><S><P><F><G><A><N><P><W><W><W><S><V><A><A><A><L><P><A><L><L><L><S><I><L><I><F><M><D><Q><Q><I><T><A><V><I><L><N><R><M><E><Y><R><L><Q><K><G><A><G><F><H><L><D><L><F><C><V><A><V><L><M><L><L><T><S><A><L><G><L><P><W><Y><V><S><A><T><V><I><S><L><A><H><M><D><S><L><R><R><E><S><R><A><C><A><P><G><E><R><P><N><F><L><G><I><R><E><Q><R><L><T><G><L><V><V><F><I><L><T><G><A><S><I><F><L><A><P><V><L><K><F><I><P><M><P><V><L><Y><G><I><F><L><Y><M><G><V><A><A><L><S><S><I><Q><F><T><N><R><V><K><L><L><L><M><P><A><K><H><Q><P><D><L><L><L><L><R><H><V><P><L><T><R><V><H><L><F><T><A><I><Q><L><A><C><L><G><L><L><W><I><I><K><S><T><P><A><A><I><I><F><P><L><M><L><L><G><L><V><G><V><R><K><A><L><E><R><V><F><S><P><Q><E><L><L><W><L><D><E><L><M><P><E><E><E><R><S><I><P><E><K><G><L><E><P><E><H><S><F><S><G><S><D><S><E><D><S><E><L><M><Y><Q><P><K><A><P><E><I><N><I><S><V><N>
Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion. Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium.<BOP>
Q9Y448
<M><A><A><P><E><A><P><P><L><D><R><V><F><R><T><T><W><L><S><T><E><C><D><S><H><P><L><P><P><S><Y><R><K><F><L><F><E><T><Q><A><A><D><L><A><G><G><T><T><V><A><A><G><N><L><L><N><E><S><E><K><D><C><G><Q><D><R><R><A><P><G><V><Q><P><C><R><L><V><T><M><T><S><V><V><K><T><V><Y><S><L><Q><P><P><S><A><L><S><G><G><Q><P><A><D><T><Q><T><R><A><T><S><K><S><L><L><P><V><R><S><K><E><V><D><V><S><K><Q><L><H><S><G><G><P><E><N><D><V><T><K><I><T><K><L><R><R><E><N><G><Q><M><K><A><T><D><T><A><T><R><R><N><V><R><K><G><Y><K><P><L><S><K><Q><K><S><E><E><E><L><K><D><K><N><Q><L><L><E><A><V><N><K><Q><L><H><Q><K><L><T><E><T><Q><G><E><L><K><D><L><T><Q><K><V><E><L><L><E><K><F><R><D><N><C><L><A><I><L><E><S><K><G><L><D><P><A><L><G><S><E><T><L><A><S><R><Q><E><S><T><T><D><H><M><D><S><M><L><L><L><E><T><L><Q><E><E><L><K><L><F><N><E><T><A><K><K><Q><M><E><E><L><Q><A><L><K><V><K><L><E><M><K><E><E><R><V><R><F><L><E><Q><Q><T><L><C><N><N><Q><V><N><D><L><T><T><A><L><K><E><M><E><Q><L><L><E><M>
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin. Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences.<BOP>
P01920
<M><S><W><K><K><A><L><R><I><P><G><G><L><R><A><A><T><V><T><L><M><L><A><M><L><S><T><P><V><A><E><G><R><D><S><P><E><D><F><V><Y><Q><F><K><A><M><C><Y><F><T><N><G><T><E><R><V><R><Y><V><T><R><Y><I><Y><N><R><E><E><Y><A><R><F><D><S><D><V><E><V><Y><R><A><V><T><P><L><G><P><P><D><A><E><Y><W><N><S><Q><K><E><V><L><E><R><T><R><A><E><L><D><T><V><C><R><H><N><Y><Q><L><E><L><R><T><T><L><Q><R><R><V><E><P><T><V><T><I><S><P><S><R><T><E><A><L><N><H><H><N><L><L><V><C><S><V><T><D><F><Y><P><A><Q><I><K><V><R><W><F><R><N><D><Q><E><E><T><T><G><V><V><S><T><P><L><I><R><N><G><D><W><T><F><Q><I><L><V><M><L><E><M><T><P><Q><H><G><D><V><Y><T><C><H><V><E><H><P><S><L><Q><N><P><I><T><V><E><W><R><A><Q><S><E><S><A><Q><S><K><M><L><S><G><I><G><G><F><V><L><G><L><I><F><L><G><L><G><L><I><I><H><H><R><S><Q><K><G><L><L><H>
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.<BOP>
Q96FX8
<M><I><R><C><G><L><A><C><E><R><C><R><W><I><L><P><L><L><L><L><S><A><I><A><F><D><I><I><A><L><A><G><R><G><W><L><Q><S><S><D><H><G><Q><T><S><S><L><W><W><K><C><S><Q><E><G><G><G><S><G><S><Y><E><E><G><C><Q><S><L><M><E><Y><A><W><G><R><A><A><A><A><M><L><F><C><G><F><I><I><L><V><I><C><F><I><L><S><F><F><A><L><C><G><P><Q><M><L><V><F><L><R><V><I><G><G><L><L><A><L><A><A><V><F><Q><I><I><S><L><V><I><Y><P><V><K><Y><T><Q><T><F><T><L><H><A><N><P><A><V><T><Y><I><Y><N><W><A><Y><G><F><G><W><A><A><T><I><I><L><I><G><C><A><F><F><F><C><C><L><P><N><Y><E><D><D><L><L><G><N><A><K><P><R><Y><F><Y><T><S><A>
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Thereby plays a role in barrier function of the skin against infection. Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions. Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis. May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4. Plays a role as an effector in the TP53-dependent apoptotic pathway. Positively regulates apoptosis in T-helper 17. Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3.<BOP>
Q9NZJ0
<M><L><F><N><S><V><L><R><Q><P><Q><L><G><V><L><R><N><G><W><S><S><Q><Y><P><L><Q><S><L><L><T><G><Y><Q><C><S><G><N><D><E><H><T><S><Y><G><E><T><G><V><P><V><P><P><F><G><C><T><F><S><S><A><P><N><M><E><H><V><L><A><V><A><N><E><E><G><F><V><R><L><Y><N><T><E><S><Q><S><F><R><K><K><C><F><K><E><W><M><A><H><W><N><A><V><F><D><L><A><W><V><P><G><E><L><K><L><V><T><A><A><G><D><Q><T><A><K><F><W><D><V><K><A><G><E><L><I><G><T><C><K><G><H><Q><C><S><L><K><S><V><A><F><S><K><F><E><K><A><V><F><C><T><G><G><R><D><G><N><I><M><V><W><D><T><R><C><N><K><K><D><G><F><Y><R><Q><V><N><Q><I><S><G><A><H><N><T><S><D><K><Q><T><P><S><K><P><K><K><K><Q><N><S><K><G><L><A><P><S><V><D><F><Q><Q><S><V><T><V><V><L><F><Q><D><E><N><T><L><V><S><A><G><A><V><D><G><I><I><K><V><W><D><L><R><K><N><Y><T><A><Y><R><Q><E><P><I><A><S><K><S><F><L><Y><P><G><S><S><T><R><K><L><G><Y><S><S><L><I><L><D><S><T><G><S><T><L><F><A><N><C><T><D><D><N><I><Y><M><F><N><M><T><G><L><K><T><S><P><V><A><I><F><N><G><H><Q><N><S><T><F><Y><V><K><S><S><L><S><P><D><D><Q><F><L><V><S><G><S><S><D><E><A><A><Y><I><W><K><V><S><T><P><W><Q><P><P><T><V><L><L><G><H><S><Q><E><V><T><S><V><C><W><C><P><S><D><F><T><K><I><A><T><C><S><D><D><N><T><L><K><I><W><R><L><N><R><G><L><E><E><K><P><G><G><D><K><L><S><T><V><G><W><A><S><Q><K><K><K><E><S><R><P><G><L><V><T><V><T><S><S><Q><S><T><P><A><K><A><P><R><A><K><C><N><P><S><N><S><S><P><S><S><A><A><C><A><P><S><C><A><G><D><L><P><L><P><S><N><T><P><T><F><S><I><K><T><S><P><A><K><A><R><S><P><I><N><R><R><G><S><V><S><S><V><S><P><K><P><P><S><S><F><K><M><S><I><R><N><W><V><T><R><T><P><S><S><S><P><P><I><T><P><P><A><S><E><T><K><I><M><S><P><R><K><A><L><I><P><V><S><Q><K><S><S><Q><A><E><A><C><S><E><S><R><N><R><V><K><R><R><L><D><S><S><C><L><E><S><V><K><Q><K><C><V><K><S><C><N><C><V><T><E><L><D><G><Q><V><E><N><L><H><L><D><L><C><C><L><A><G><N><Q><E><D><L><S><K><D><S><L><G><P><T><K><S><S><K><I><E><G><A><G><T><S><I><S><E><P><P><S><P><I><S><P><Y><A><S><E><S><C><G><T><L><P><L><P><L><R><P><C><G><E><G><S><E><M><V><G><K><E><N><S><S><P><E><N><K><N><W><L><L><A><M><A><A><K><R><K><A><E><N><P><S><P><R><S><P><S><S><Q><T><P><N><S><R><R><Q><S><G><K><K><L><P><S><P><V><T><I><T><P><S><S><M><R><K><I><C><T><Y><F><H><R><K><S><Q><E><D><F><C><G><P><E><H><S><T><E><L>
Substrate-specific adapter of a DCX. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis. The DDB1-CUL4A-DTL E3 ligase complex regulates the circadian clock function by mediating the ubiquitination and degradation of CRY1.<BOP>
Q9NWN3
<M><H><L><K><P><Y><W><K><L><Q><K><K><E><H><P><P><E><V><S><R><E><T><Q><R><T><P><M><N><H><Q><K><A><V><N><D><E><T><C><K><A><S><H><I><T><S><S><V><F><P><S><A><S><L><G><K><A><S><S><R><K><P><F><G><I><L><S><P><N><V><L><C><S><M><S><G><K><S><P><V><E><S><S><L><N><V><K><T><K><K><N><A><P><S><A><T><I><H><Q><G><E><E><E><G><P><L><D><I><W><A><V><V><K><P><G><N><T><K><E><K><I><A><F><F><A><S><H><Q><C><S><N><R><I><G><S><M><K><I><K><S><S><W><D><I><D><G><R><A><T><K><R><R><K><K><S><G><D><L><K><K><A><K><V><Q><V><E><R><M><R><E><V><N><S><R><C><Y><Q><P><E><P><F><A><C><G><I><E><H><C><S><V><H><Y><V><S><D><S><G><D><G><V><Y><A><G><R><P><L><S><V><I><Q><M><V><A><F><L><E><Q><R><A><S><A><L><L><A><S><C><S><K><N><C><T><N><S><P><A><I><V><R><F><S><G><Q><S><R><G><V><P><A><V><S><E><S><Y><S><A><P><G><A><C><E><E><P><T><E><R><G><N><L><E><V><G><E><P><Q><S><E><P><V><R><V><L><D><M><V><A><K><L><E><S><E><C><L><K><R><Q><G><Q><R><E><P><G><S><L><S><R><N><N><S><F><R><R><N><V><G><R><V><L><L><A><N><S><T><Q><A><D><E><G><K><T><K><K><G><V><L><E><A><P><D><T><Q><V><N><P><V><G><S><V><S><V><D><C><G><P><S><R><A><D><R><C><S><P><K><E><D><Q><A><W><D><G><A><S><Q><D><C><P><P><L><P><A><G><V><S><F><H><I><D><S><A><E><L><E><P><G><S><Q><T><A><V><K><N><S><N><R><Y><D><V><E><M><T><D><E><L><V><G><L><P><F><S><S><H><T><Y><S><Q><A><S><E><L><P><T><D><A><V><D><C><M><S><R><E><L><V><S><L><T><S><R><N><P><D><Q><R><K><E><S><L><C><I><S><I><T><V><S><K><V><D><K><D><Q><P><S><I><L><N><S><C><E><D><P><V><P><G><M><L><F><F><L><P><P><G><Q><H><L><S><D><Y><S><Q><L><N><E><S><T><T><K><E><S><S><E><A><S><Q><L><E><D><A><A><G><G><D><S><A><S><E><E><K><S><G><S><A><E><P><F><V><L><P><A><S><S><V><E><S><T><L><P><V><L><E><A><S><S><W><K><K><Q><V><S><H><D><F><L><E><T><R><F><K><I><Q><Q><L><L><E><P><Q><Q><Y><M><A><F><L><P><H><H><I><M><V><K><I><F><R><L><L><P><T><K><S><L><V><A><L><K><C><T><C><C><Y><F><K><F><I><I><E><Y><Y><N><I><R><P><A><D><S><R><W><V><R><D><P><R><Y><R><E><D><P><C><K><Q><C><K><K><K><Y><V><K><G><D><V><S><L><C><R><W><H><P><K><P><Y><C><Q><A><L><P><Y><G><P><G><Y><W><M><C><C><H><R><S><Q><K><G><F><P><G><C><K><L><G><L><H><D><N><H><W><V><P><A><C><H><S><F><N><R><A><I><H><K><K><A><K><G><T><E><A><E><E><E><Y>
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<BOP>
P21673
<M><A><K><F><V><I><R><P><A><T><A><A><D><C><S><D><I><L><R><L><I><K><E><L><A><K><Y><E><Y><M><E><E><Q><V><I><L><T><E><K><D><L><L><E><D><G><F><G><E><H><P><F><Y><H><C><L><V><A><E><V><P><K><E><H><W><T><P><E><G><H><S><I><V><G><F><A><M><Y><Y><F><T><Y><D><P><W><I><G><K><L><L><Y><L><E><D><F><F><V><M><S><D><Y><R><G><F><G><I><G><S><E><I><L><K><N><L><S><Q><V><A><M><R><C><R><C><S><S><M><H><F><L><V><A><E><W><N><E><P><S><I><N><F><Y><K><R><R><G><A><S><D><L><S><S><E><E><G><W><R><L><F><K><I><D><K><E><Y><L><L><K><M><A><T><E><E>
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3-diaminopropane and 1,5-diaminopentane.<BOP>
Q96P09
<M><T><G><Y><E><A><R><L><I><T><F><G><T><W><M><Y><S><V><N><K><E><Q><L><A><R><A><G><F><Y><A><I><G><Q><E><D><K><V><Q><C><F><H><C><G><G><G><L><A><N><W><K><P><K><E><D><P><W><E><Q><H><A><K><W><Y><P><G><C><K><Y><L><L><E><E><K><G><H><E><Y><I><N><N><I><H><L><T><R><S><L><E><G><A><L><V><Q><T><T><K><K><T><P><S><L><T><K><R><I><S><D><T><I><F><P><N><P><M><L><Q><E><A><I><R><M><G><F><D><F><K><D><V><K><K><I><M><E><E><R><I><Q><T><S><G><S><N><Y><K><T><L><E><V><L><V><A><D><L><V><S><A><Q><K><D><T><T><E><N><E><L><N><Q><T><S><L><Q><R><E><I><S><P><E><E><P><L><R><R><L><Q><E><E><K><L><C><K><I><C><M><D><R><H><I><A><V><V><F><I><P><C><G><H><L><V><T><C><K><Q><C><A><E><A><V><D><R><C><P><M><C><S><A><V><I><D><F><K><Q><R><V><F><M><S>
Protects against apoptosis mediated by BAX.<BOP>
Q969G5
<M><R><E><S><A><L><E><R><G><P><V><P><E><A><P><A><G><G><P><V><H><A><V><T><V><V><T><L><L><E><K><L><A><S><M><L><E><T><L><R><E><R><Q><G><G><L><A><R><R><Q><G><G><L><A><G><S><V><R><R><I><Q><S><G><L><G><A><L><S><R><S><H><D><T><T><S><N><T><L><A><Q><L><L><A><K><A><E><R><V><S><S><H><A><N><A><A><Q><E><R><A><V><R><R><A><A><Q><V><Q><R><L><E><A><N><H><G><L><L><V><A><R><G><K><L><H><V><L><L><F><K><E><E><G><E><V><P><A><S><A><F><Q><K><A><P><E><P><L><G><P><A><D><Q><S><E><L><G><P><E><Q><L><E><A><E><V><G><E><S><S><D><E><E><P><V><E><S><R><A><Q><R><L><R><R><T><G><L><Q><K><V><Q><S><L><R><R><A><L><S><G><R><K><G><P><A><A><P><P><P><T><P><V><K><P><P><R><L><G><P><G><R><S><A><E><A><Q><P><E><A><Q><P><A><L><E><P><T><L><E><P><E><P><P><Q><D><T><E><E><D><P><G><R><P><G><A><A><E><E><A><L><L><Q><M><E><S><V><A>
Regulates the traffic and/or budding of caveolae.<BOP>
Q9HCJ5
<M><A><E><R><G><Q><Q><P><P><P><A><K><R><L><C><C><R><P><G><G><G><G><G><G><G><G><S><S><G><G><G><G><G><A><G><G><G><Y><S><S><A><C><R><P><G><P><R><A><G><G><A><A><A><A><A><A><C><G><G><G><A><A><L><G><L><L><P><P><G><K><T><Q><S><P><E><S><L><L><D><I><A><A><R><R><V><A><E><K><W><P><F><Q><R><V><E><E><R><F><E><R><I><P><E><P><V><Q><R><R><I><V><Y><W><S><F><P><R><S><E><R><E><I><C><M><Y><S><S><F><N><T><G><G><G><A><A><G><G><P><G><D><D><S><G><G><G><G><G><A><G><G><G><G><G><G><G><S><S><S><S><P><A><A><T><S><A><A><A><T><S><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><A><G><A><G><A><P><S><V><G><A><A><G><A><A><D><G><G><D><E><T><R><L><P><F><R><R><G><I><A><L><L><E><S><G><C><V><D><N><V><L><Q><V><G><F><H><L><S><G><T><V><T><E><P><A><I><Q><S><E><P><E><T><V><C><N><V><A><I><S><F><D><R><C><K><I><T><S><V><T><C><S><C><G><N><K><D><I><F><Y><C><A><H><V><V><A><L><S><L><Y><R><I><R><K><P><D><Q><V><K><L><H><L><P><I><S><E><T><L><F><Q><M><N><R><D><Q><L><Q><K><F><V><Q><Y><L><I><T><V><H><H><T><E><V><L><P><T><A><Q><K><L><A><D><E><I><L><S><Q><N><S><E><I><N><Q><V><H><G><A><P><D><P><T><A><G><A><S><I><D><D><E><N><C><W><H><L><D><E><E><Q><V><Q><E><Q><V><K><L><F><L><S><Q><G><G><Y><H><G><S><G><K><Q><L><N><L><L><F><A><K><V><R><E><M><L><K><M><R><D><S><N><G><A><R><M><L><T><L><I><T><E><Q><F><M><A><D><P><R><L><S><L><W><R><Q><Q><G><T><A><M><T><D><K><Y><R><Q><L><W><D><E><L><G><A><L><W><M><C><I><V><L><N><P><H><C><K><L><E><Q><K><A><S><W><L><K><Q><L><K><K><W><N><S><V><D><V><C><P><W><E><D><G><N><H><G><S><E><L><P><N><L><T><N><A><L><P><Q><G><A><N><A><N><Q><D><S><S><N><R><P><H><R><T><V><F><T><R><A><I><E><A><C><D><L><H><W><Q><D><S><H><L><Q><H><I><I><S><S><D><L><Y><T><N><Y><C><Y><H><D><D><T><E><N><S><L><F><D><S><R><G><W><P><L><W><H><E><H><V><P><T><A><C><A><R><V><D><A><L><R><S><H><G><Y><P><R><E><A><L><R><L><A><I><A><I><V><N><T><L><R><R><Q><Q><Q><K><Q><L><E><M><F><R><T><Q><K><K><E><L><P><H><K><N><I><T><S><I><T><N><L><E><G><W><V><G><H><P><L><D><P><V><G><T><L><F><S><S><L><M><E><A><C><R><I><D><D><E><N><L><S><G><F><S><D><F><T><E><N><M><G><Q><C><K><S><L><E><Y><Q><H><L><P><A><H><K><F><L><E><E><G><E><S><Y><L><T><L><A><V><E><V><A><L><I><G><L><G><Q><Q><R><I><M><P><D><G><L><Y><T><Q><E><K><V><C><R><N><E><E><Q><L><I><S><K><L><Q><E><I><E><L><D><D><T><L><V><K><I><F><R><K><Q><A><V><F><L><L><E><A><G><P><Y><S><G><L><G><E><I><I><H><R><E><S><V><P><M><H><T><F><A><K><Y><L><F><T><S><L><L><P><H><D><A><E><L><A><Y><K><I><A><L><R><A><M><R><L><L><V><L><E><S><T><A><P><S><G><D><L><T><R><P><H><H><I><A><S><V><V><P><N><R><Y><P><R><W><F><T><L><S><H><I><E><S><Q><Q><C><E><L><A><S><T><M><L><T><A><A><K><G><D><V><R><R><L><E><T><V><L><E><S><I><Q><K><N><I><H><S><S><S><H><I><F><K><L><A><Q><D><A><F><K><I><A><T><L><M><D><S><L><P><D><I><T><L><L><K><V><S><L><E><L><G><L><Q><V><M><R><M><T><L><S><T><L><N><W><R><R><R><E><M><V><R><W><L><V><T><C><A><T><E><V><G><V><Y><A><L><D><S><I><M><Q><T><W><F><T><L><F><T><P><T><E><A><T><S><I><V><A><T><T><V><M><S><N><S><T><I><V><R><L><H><L><D><C><H><Q><Q><E><K><L><A><S><S><A><R><T><L><A><L><Q><C><A><M><K><D><P><Q><N><C><A><L><S><A><L><T><L><C><E><K><D><H><I><A><F><E><T><A><Y><Q><I><V><L><D><A><A><T><T><G><M><S><Y><T><Q><L><F><T><I><A><R><Y><M><E><H><R><G><Y><P><M><R><A><Y><K><L><A><T><L><A><M><T><H><L><N><L><S><Y><N><Q><D><T><H><P><A><I><N><D><V><L><W><A><C><A><L><S><H><S><L><G><K><N><E><L><A><A><I><I><P><L><V><V><K><S><V><K><C><A><T><V><L><S><D><I><L><R><R><C><T><L><T><T><P><G><M><V><G><L><H><G><R><R><N><S><G><K><L><M><S><L><D><K><A><P><L><R><Q><L><L><D><A><T><I><G><A><Y><I><N><T><T><H><S><R><L><T><H><I><S><P><R><H><Y><S><E><F><I><E><F><L><S><K><A><R><E><T><F><L><M><A><H><D><G><H><I><Q><F><T><Q><F><I><D><N><L><K><Q><I><Y><K><G><K><K><K><L><M><M><L><V><R><E><R><F><G>
involved in nervous system development, important for striatal morphology and motor regulation.<BOP>
Q92915
<M><A><A><A><I><A><S><G><L><I><R><Q><K><R><Q><A><R><E><Q><H><W><D><R><P><S><A><S><R><R><R><S><S><P><S><K><N><R><G><L><C><N><G><N><L><V><D><I><F><S><K><V><R><I><F><G><L><K><K><R><R><L><R><R><Q><D><P><Q><L><K><G><I><V><T><R><L><Y><C><R><Q><G><Y><Y><L><Q><M><H><P><D><G><A><L><D><G><T><K><D><D><S><T><N><S><T><L><F><N><L><I><P><V><G><L><R><V><V><A><I><Q><G><V><K><T><G><L><Y><I><A><M><N><G><E><G><Y><L><Y><P><S><E><L><F><T><P><E><C><K><F><K><E><S><V><F><E><N><Y><Y><V><I><Y><S><S><M><L><Y><R><Q><Q><E><S><G><R><A><W><F><L><G><L><N><K><E><G><Q><A><M><K><G><N><R><V><K><K><T><K><P><A><A><H><F><L><P><K><P><L><E><V><A><M><Y><R><E><P><S><L><H><D><V><G><E><T><V><P><K><P><G><V><T><P><S><K><S><T><S><A><S><A><I><M><N><G><G><K><P><V><N><K><S><K><T><T>
Probably involved in nervous system development and function.<BOP>
P56381
<M><V><A><Y><W><R><Q><A><G><L><S><Y><I><R><Y><S><Q><I><C><A><K><A><V><R><D><A><L><K><T><E><F><K><A><N><A><E><K><T><S><G><S><N><V><K><I><V><K><V><K><K><E>
Subunit epsilon, of the mitochondrial membrane ATP synthase complex. May be essential for the assembly of F(1) and may play an important role in the incorporation of the hydrophobic subunit c into the F(1)-c oligomer rotor of the mitochondrial ATP synthase complex.<BOP>
Q11201
<M><V><T><L><R><K><R><T><L><K><V><L><T><F><L><V><L><F><I><F><L><T><S><F><F><L><N><Y><S><H><T><M><V><A><T><T><W><F><P><K><Q><M><V><L><E><L><S><E><N><L><K><R><L><I><K><H><R><P><C><T><C><T><H><C><I><G><Q><R><K><L><S><A><W><F><D><E><R><F><N><Q><T><M><Q><P><L><L><T><A><Q><N><A><L><L><E><D><D><T><Y><R><W><W><L><R><L><Q><R><E><K><K><P><N><N><L><N><D><T><I><K><E><L><F><R><V><V><P><G><N><V><D><P><M><L><E><K><R><S><V><G><C><R><R><C><A><V><V><G><N><S><G><N><L><R><E><S><S><Y><G><P><E><I><D><S><H><D><F><V><L><R><M><N><K><A><P><T><A><G><F><E><A><D><V><G><T><K><T><T><H><H><L><V><Y><P><E><S><F><R><E><L><G><D><N><V><S><M><I><L><V><P><F><K><T><I><D><L><E><W><V><V><S><A><I><T><T><G><T><I><S><H><T><Y><I><P><V><P><A><K><I><R><V><K><Q><D><K><I><L><I><Y><H><P><A><F><I><K><Y><V><F><D><N><W><L><Q><G><H><G><R><Y><P><S><T><G><I><L><S><V><I><F><S><M><H><V><C><D><E><V><D><L><Y><G><F><G><A><D><S><K><G><N><W><H><H><Y><W><E><N><N><P><S><A><G><A><F><R><K><T><G><V><H><D><A><D><F><E><S><N><V><T><A><T><L><A><S><I><N><K><I><R><I><F><K><G><R>
A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser. Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively.<BOP>
Q8WVH0
<M><A><F><M><V><K><T><M><V><G><G><Q><L><K><N><L><T><G><S><L><G><G><G><E><D><K><G><D><G><D><K><S><A><A><E><A><Q><G><M><S><R><E><E><Y><E><E><Y><Q><K><Q><L><V><E><E><K><M><E><R><D><A><Q><F><T><Q><R><K><A><E><R><A><T><L><R><S><H><F><R><D><K><Y><R><L><P><K><N><E><T><D><E><S><Q><I><Q><M><A><G><G><D><V><E><L><P><R><E><L><A><K><M><I><E><E><D><T><E><E><E><E><E><K><A><S><V><L><G><Q><L><A><S><L><P><G><L><N><L><G><S><L><K><D><K><A><Q><A><T><L><G><D><L><K><Q><S><A><E><K><C><H><V><M>
Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release.<BOP>
Q06055
<M><F><A><C><S><K><F><V><S><T><P><S><L><V><K><S><T><S><Q><L><L><S><R><P><L><S><A><V><V><L><K><R><P><E><I><L><T><D><E><S><L><S><S><L><A><V><S><C><P><L><T><S><L><V><S><S><R><S><F><Q><T><S><A><I><S><R><D><I><D><T><A><A><K><F><I><G><A><G><A><A><T><V><G><V><A><G><S><G><A><G><I><G><T><V><F><G><S><L><I><I><G><Y><A><R><N><P><S><L><K><Q><Q><L><F><S><Y><A><I><L><G><F><A><L><S><E><A><M><G><L><F><C><L><M><V><A><F><L><I><L><F><A><M>
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.<BOP>
P55735
<M><V><S><V><I><N><T><V><D><T><S><H><E><D><M><I><H><D><A><Q><M><D><Y><Y><G><T><R><L><A><T><C><S><S><D><R><S><V><K><I><F><D><V><R><N><G><G><Q><I><L><I><A><D><L><R><G><H><E><G><P><V><W><Q><V><A><W><A><H><P><M><Y><G><N><I><L><A><S><C><S><Y><D><R><K><V><I><I><W><R><E><E><N><G><T><W><E><K><S><H><E><H><A><G><H><D><S><S><V><N><S><V><C><W><A><P><H><D><Y><G><L><I><L><A><C><G><S><S><D><G><A><I><S><L><L><T><Y><T><G><E><G><Q><W><E><V><K><K><I><N><N><A><H><T><I><G><C><N><A><V><S><W><A><P><A><V><V><P><G><S><L><I><D><H><P><S><G><Q><K><P><N><Y><I><K><R><F><A><S><G><G><C><D><N><L><I><K><L><W><K><E><E><E><D><G><Q><W><K><E><E><Q><K><L><E><A><H><S><D><W><V><R><D><V><A><W><A><P><S><I><G><L><P><T><S><T><I><A><S><C><S><Q><D><G><R><V><F><I><W><T><C><D><D><A><S><S><N><T><W><S><P><K><L><L><H><K><F><N><D><V><V><W><H><V><S><W><S><I><T><A><N><I><L><A><V><S><G><G><D><N><K><V><T><L><W><K><E><S><V><D><G><Q><W><V><C><I><S><D><V><N><K><G><Q><G><S><V><S><A><S><V><T><E><G><Q><Q><N><E><Q>
Functions as a component of the nuclear pore complex. As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex.<BOP>
Q5VV42
<M><P><S><A><S><C><D><T><L><L><D><D><I><E><D><I><V><S><Q><E><D><S><K><P><Q><D><R><H><F><V><R><K><D><V><V><P><K><V><R><R><R><N><T><Q><K><Y><L><Q><E><E><E><N><S><P><P><S><D><S><T><I><P><G><I><Q><K><I><W><I><R><T><W><G><C><S><H><N><N><S><D><G><E><Y><M><A><G><Q><L><A><A><Y><G><Y><K><I><T><E><N><A><S><D><A><D><L><W><L><L><N><S><C><T><V><K><N><P><A><E><D><H><F><R><N><S><I><K><K><A><Q><E><E><N><K><K><I><V><L><A><G><C><V><P><Q><A><Q><P><R><Q><D><Y><L><K><G><L><S><I><I><G><V><Q><Q><I><D><R><V><V><E><V><V><E><E><T><I><K><G><H><S><V><R><L><L><G><Q><K><K><D><N><G><R><R><L><G><G><A><R><L><D><L><P><K><I><R><K><N><P><L><I><E><I><I><S><I><N><T><G><C><L><N><A><C><T><Y><C><K><T><K><H><A><R><G><N><L><A><S><Y><P><I><D><E><L><V><D><R><A><K><Q><S><F><Q><E><G><V><C><E><I><W><L><T><S><E><D><T><G><A><Y><G><R><D><I><G><T><N><L><P><T><L><L><W><K><L><V><E><V><I><P><E><G><A><M><L><R><L><G><M><T><N><P><P><Y><I><L><E><H><L><E><E><M><A><K><I><L><N><H><P><R><V><Y><A><F><L><H><I><P><V><Q><S><A><S><D><S><V><L><M><E><M><K><R><E><Y><C><V><A><D><F><K><R><V><V><D><F><L><K><E><K><V><P><G><I><T><I><A><T><D><I><I><C><G><F><P><G><E><T><D><Q><D><F><Q><E><T><V><K><L><V><E><E><Y><K><F><P><S><L><F><I><N><Q><F><Y><P><R><P><G><T><P><A><A><K><M><E><Q><V><P><A><Q><V><K><K><Q><R><T><K><D><L><S><R><V><F><H><S><Y><S><P><Y><D><H><K><I><G><E><R><Q><Q><V><L><V><T><E><E><S><F><D><S><K><F><Y><V><A><H><N><Q><F><Y><E><Q><V><L><V><P><K><N><P><A><F><M><G><K><M><V><E><V><D><I><Y><E><S><G><K><H><F><M><K><G><Q><P><V><S><D><A><K><V><Y><T><P><S><I><S><K><P><L><A><K><G><E><V><S><G><L><T><K><D><F><R><N><G><L><G><N><Q><L><S><S><G><S><H><T><S><A><A><S><Q><C><D><S><A><S><S><R><M><V><L><P><M><P><R><L><H><Q><D><C><A><L><R><M><S><V><G><L><A><L><L><G><L><L><F><A><F><F><V><K><V><Y><N>
Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.<BOP>
Q16881
<M><G><C><A><E><G><K><A><V><A><A><A><A><P><T><E><L><Q><T><K><G><K><N><G><D><G><R><R><R><S><A><K><D><H><H><P><G><K><T><L><P><E><N><P><A><G><F><T><S><T><A><T><A><D><S><R><A><L><L><Q><A><Y><I><D><G><H><S><V><V><I><F><S><R><S><T><C><T><R><C><T><E><V><K><K><L><F><K><S><L><C><V><P><Y><F><V><L><E><L><D><Q><T><E><D><G><R><A><L><E><G><T><L><S><E><L><A><A><E><T><D><L><P><V><V><F><V><K><Q><R><K><I><G><G><H><G><P><T><L><K><A><Y><Q><E><G><R><L><Q><K><L><L><K><M><N><G><P><E><D><L><P><K><S><Y><D><Y><D><L><I><I><I><G><G><G><S><G><G><L><A><A><A><K><E><A><A><Q><Y><G><K><K><V><M><V><L><D><F><V><T><P><T><P><L><G><T><R><W><G><L><G><G><T><C><V><N><V><G><C><I><P><K><K><L><M><H><Q><A><A><L><L><G><Q><A><L><Q><D><S><R><N><Y><G><W><K><V><E><E><T><V><K><H><D><W><D><R><M><I><E><A><V><Q><N><H><I><G><S><L><N><W><G><Y><R><V><A><L><R><E><K><K><V><V><Y><E><N><A><Y><G><Q><F><I><G><P><H><R><I><K><A><T><N><N><K><G><K><E><K><I><Y><S><A><E><R><F><L><I><A><T><G><E><R><P><R><Y><L><G><I><P><G><D><K><E><Y><C><I><S><S><D><D><L><F><S><L><P><Y><C><P><G><K><T><L><V><V><G><A><S><Y><V><A><L><E><C><A><G><F><L><A><G><I><G><L><D><V><T><V><M><V><R><S><I><L><L><R><G><F><D><Q><D><M><A><N><K><I><G><E><H><M><E><E><H><G><I><K><F><I><R><Q><F><V><P><I><K><V><E><Q><I><E><A><G><T><P><G><R><L><R><V><V><A><Q><S><T><N><S><E><E><I><I><E><G><E><Y><N><T><V><M><L><A><I><G><R><D><A><C><T><R><K><I><G><L><E><T><V><G><V><K><I><N><E><K><T><G><K><I><P><V><T><D><E><E><Q><T><N><V><P><Y><I><Y><A><I><G><D><I><L><E><D><K><V><E><L><T><P><V><A><I><Q><A><G><R><L><L><A><Q><R><L><Y><A><G><S><T><V><K><C><D><Y><E><N><V><P><T><T><V><F><T><P><L><E><Y><G><A><C><G><L><S><E><E><K><A><V><E><K><F><G><E><E><N><I><E><V><Y><H><S><Y><F><W><P><L><E><W><T><I><P><S><R><D><N><N><K><C><Y><A><K><I><I><C><N><T><K><D><N><E><R><V><V><G><F><H><V><L><G><P><N><A><G><E><V><T><Q><G><F><A><A><A><L><K><C><G><L><T><K><K><Q><L><D><S><T><I><G><I><H><P><V><C><A><E><V><F><T><T><L><S><V><T><K><R><S><G><A><S><I><L><Q><A><G><C><U><G>
Reduces disulfideprotein thioredoxin. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis. Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. Enhances the transcriptional activity of the estrogen receptor ESR2 only. Mediates cell death induced by a combination of interferon-beta and retinoic acid.<BOP>
P20674
<M><L><G><A><A><L><R><R><C><A><V><A><A><T><T><R><A><D><P><R><G><L><L><H><S><A><R><T><P><G><P><A><V><A><I><Q><S><V><R><C><Y><S><H><G><S><Q><E><T><D><E><E><F><D><A><R><W><V><T><Y><F><N><K><P><D><I><D><A><W><E><L><R><K><G><I><N><T><L><V><T><Y><D><M><V><P><E><P><K><I><I><D><A><A><L><R><A><C><R><R><L><N><D><F><A><S><T><V><R><I><L><E><V><V><K><D><K><A><G><P><H><K><E><I><Y><P><Y><V><I><Q><E><L><R><P><T><L><N><E><L><G><I><S><T><P><E><E><L><G><L><D><K><V>
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.<BOP>
P49914
<M><A><A><A><A><V><S><S><A><K><R><S><L><R><G><E><L><K><Q><R><L><R><A><M><S><A><E><E><R><L><R><Q><S><R><V><L><S><Q><K><V><I><A><H><S><E><Y><Q><K><S><K><R><I><S><I><F><L><S><M><Q><D><E><I><E><T><E><E><I><I><K><D><I><F><Q><R><G><K><I><C><F><I><P><R><Y><R><F><Q><S><N><H><M><D><M><V><R><I><E><S><P><E><E><I><S><L><L><P><K><T><S><W><N><I><P><Q><P><G><E><G><D><V><R><E><E><A><L><S><T><G><G><L><D><L><I><F><M><P><G><L><G><F><D><K><H><G><N><R><L><G><R><G><K><G><Y><Y><D><A><Y><L><K><R><C><L><Q><H><Q><E><V><K><P><Y><T><L><A><L><A><F><K><E><Q><I><C><L><Q><V><P><V><N><E><N><D><M><K><V><D><E><V><L><Y><E><D><S><S><T><A>
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.<BOP>
Q8NGS1
<M><K><R><E><N><Q><S><S><V><S><E><F><L><L><L><D><L><P><I><W><P><E><Q><Q><A><V><F><F><T><L><F><L><G><M><Y><L><I><T><V><L><G><N><L><L><I><I><L><L><I><R><L><D><S><H><L><H><T><P><M><F><F><F><L><S><H><L><A><L><T><D><I><S><L><S><S><V><T><V><P><K><M><L><L><S><M><Q><T><Q><D><Q><S><I><L><Y><A><G><C><V><T><Q><M><Y><F><F><I><F><F><T><D><L><D><N><F><L><L><T><S><M><A><Y><D><R><Y><V><A><I><C><H><P><L><R><Y><T><T><I><M><K><E><G><L><C><N><L><L><V><T><V><S><W><I><L><S><C><T><N><A><L><S><H><T><L><L><L><A><Q><L><S><F><C><A><D><N><T><I><P><H><F><F><C><D><L><V><A><L><L><K><L><S><C><S><D><I><S><L><N><E><L><V><I><F><T><V><G><Q><A><V><I><T><L><P><L><I><C><I><L><I><S><Y><G><H><I><G><V><T><I><L><K><A><P><S><T><K><G><I><F><K><A><L><S><T><C><G><S><H><L><S><V><V><S><L><Y><Y><G><T><I><I><G><L><Y><F><L><P><S><S><S><A><S><S><D><K><D><V><I><A><S><V><M><Y><T><V><I><T><P><L><L><N><P><F><I><Y><S><L><R><N><R><D><I><K><G><A><L><E><R><L><F><N><R><A><T><V><L><S><Q>
Odorant receptor.<BOP>
P80404
<M><A><S><M><L><L><A><Q><R><L><A><C><S><F><Q><H><S><Y><R><L><L><V><P><G><S><R><H><I><S><Q><A><A><A><K><V><D><V><E><F><D><Y><D><G><P><L><M><K><T><E><V><P><G><P><R><S><Q><E><L><M><K><Q><L><N><I><I><Q><N><A><E><A><V><H><F><F><C><N><Y><E><E><S><R><G><N><Y><L><V><D><V><D><G><N><R><M><L><D><L><Y><S><Q><I><S><S><V><P><I><G><Y><S><H><P><A><L><L><K><L><I><Q><Q><P><Q><N><A><S><M><F><V><N><R><P><A><L><G><I><L><P><P><E><N><F><V><E><K><L><R><Q><S><L><L><S><V><A><P><K><G><M><S><Q><L><I><T><M><A><C><G><S><C><S><N><E><N><A><L><K><T><I><F><M><W><Y><R><S><K><E><R><G><Q><R><G><F><S><Q><E><E><L><E><T><C><M><I><N><Q><A><P><G><C><P><D><Y><S><I><L><S><F><M><G><A><F><H><G><R><T><M><G><C><L><A><T><T><H><S><K><A><I><H><K><I><D><I><P><S><F><D><W><P><I><A><P><F><P><R><L><K><Y><P><L><E><E><F><V><K><E><N><Q><Q><E><E><A><R><C><L><E><E><V><E><D><L><I><V><K><Y><R><K><K><K><K><T><V><A><G><I><I><V><E><P><I><Q><S><E><G><G><D><N><H><A><S><D><D><F><F><R><K><L><R><D><I><A><R><K><H><G><C><A><F><L><V><D><E><V><Q><T><G><G><G><C><T><G><K><F><W><A><H><E><H><W><G><L><D><D><P><A><D><V><M><T><F><S><K><K><M><M><T><G><G><F><F><H><K><E><E><F><R><P><N><A><P><Y><R><I><F><N><T><W><L><G><D><P><S><K><N><L><L><L><A><E><V><I><N><I><I><K><R><E><D><L><L><N><N><A><A><H><A><G><K><A><L><L><T><G><L><L><D><L><Q><A><R><Y><P><Q><F><I><S><R><V><R><G><R><G><T><F><C><S><F><D><T><P><D><D><S><I><R><N><K><L><I><L><I><A><R><N><K><G><V><V><L><G><G><C><G><D><K><S><I><R><F><R><P><T><L><V><F><R><D><H><H><A><H><L><F><L><N><I><F><S><D><I><L><A><D><F><K>
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively.<BOP>
P16619
<M><Q><V><S><T><A><A><L><A><V><L><L><C><T><M><A><L><C><N><Q><V><L><S><A><P><L><A><A><D><T><P><T><A><C><C><F><S><Y><T><S><R><Q><I><P><Q><N><F><I><A><D><Y><F><E><T><S><S><Q><C><S><K><P><S><V><I><F><L><T><K><R><G><R><Q><V><C><A><D><P><S><E><E><W><V><Q><K><Y><V><S><D><L><E><L><S><A>
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.<BOP>
P23769
<M><E><V><A><P><E><Q><P><R><W><M><A><H><P><A><V><L><N><A><Q><H><P><D><S><H><H><P><G><L><A><H><N><Y><M><E><P><A><Q><L><L><P><P><D><E><V><D><V><F><F><N><H><L><D><S><Q><G><N><P><Y><Y><A><N><P><A><H><A><R><A><R><V><S><Y><S><P><A><H><A><R><L><T><G><G><Q><M><C><R><P><H><L><L><H><S><P><G><L><P><W><L><D><G><G><K><A><A><L><S><A><A><A><A><H><H><H><N><P><W><T><V><S><P><F><S><K><T><P><L><H><P><S><A><A><G><G><P><G><G><P><L><S><V><Y><P><G><A><G><G><G><S><G><G><G><S><G><S><S><V><A><S><L><T><P><T><A><A><H><S><G><S><H><L><F><G><F><P><P><T><P><P><K><E><V><S><P><D><P><S><T><T><G><A><A><S><P><A><S><S><S><A><G><G><S><A><A><R><G><E><D><K><D><G><V><K><Y><Q><V><S><L><T><E><S><M><K><M><E><S><G><S><P><L><R><P><G><L><A><T><M><G><T><Q><P><A><T><H><H><P><I><P><T><Y><P><S><Y><V><P><A><A><A><H><D><Y><S><S><G><L><F><H><P><G><G><F><L><G><G><P><A><S><S><F><T><P><K><Q><R><S><K><A><R><S><C><S><E><G><R><E><C><V><N><C><G><A><T><A><T><P><L><W><R><R><D><G><T><G><H><Y><L><C><N><A><C><G><L><Y><H><K><M><N><G><Q><N><R><P><L><I><K><P><K><R><R><L><S><A><A><R><R><A><G><T><C><C><A><N><C><Q><T><T><T><T><T><L><W><R><R><N><A><N><G><D><P><V><C><N><A><C><G><L><Y><Y><K><L><H><N><V><N><R><P><L><T><M><K><K><E><G><I><Q><T><R><N><R><K><M><S><N><K><S><K><K><S><K><K><G><A><E><C><F><E><E><L><S><K><C><M><Q><E><K><S><S><P><F><S><A><A><A><L><A><G><H><M><A><P><V><G><H><L><P><P><F><S><H><S><G><H><I><L><P><T><P><T><P><I><H><P><S><S><S><L><S><F><G><H><P><H><P><S><S><M><V><T><A><M><G>
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.<BOP>
Q9Y210
<M><S><Q><S><P><A><F><G><P><R><R><G><S><S><P><R><G><A><A><G><A><A><A><R><R><N><E><S><Q><D><Y><L><L><M><D><S><E><L><G><E><D><G><C><P><Q><A><P><L><P><C><Y><G><Y><Y><P><C><F><R><G><S><D><N><R><L><A><H><R><R><Q><T><V><L><R><E><K><G><R><R><L><A><N><R><G><P><A><Y><M><F><S><D><R><S><T><S><L><S><I><E><E><E><R><F><L><D><A><A><E><Y><G><N><I><P><V><V><R><K><M><L><E><E><C><H><S><L><N><V><N><C><V><D><Y><M><G><Q><N><A><L><Q><L><A><V><A><N><E><H><L><E><I><T><E><L><L><L><K><K><E><N><L><S><R><V><G><D><A><L><L><L><A><I><S><K><G><Y><V><R><I><V><E><A><I><L><S><H><P><A><F><A><E><G><K><R><L><A><T><S><P><S><Q><S><E><L><Q><Q><D><D><F><Y><A><Y><D><E><D><G><T><R><F><S><H><D><V><T><P><I><I><L><A><A><H><C><Q><E><Y><E><I><V><H><T><L><L><R><K><G><A><R><I><E><R><P><H><D><Y><F><C><K><C><N><D><C><N><Q><K><Q><K><H><D><S><F><S><H><S><R><S><R><I><N><A><Y><K><G><L><A><S><P><A><Y><L><S><L><S><S><E><D><P><V><M><T><A><L><E><L><S><N><E><L><A><V><L><A><N><I><E><K><E><F><K><N><D><Y><K><K><L><S><M><Q><C><K><D><F><V><V><G><L><L><D><L><C><R><N><T><E><E><V><E><A><I><L><N><G><D><V><E><T><L><Q><S><G><D><H><G><R><P><N><L><S><R><L><K><L><A><I><K><Y><E><V><K><K><F><V><A><H><P><N><C><Q><Q><Q><L><L><S><I><W><Y><E><N><L><S><G><L><R><Q><Q><T><M><A><V><K><F><L><V><V><L><A><V><A><I><G><L><P><F><L><A><L><I><Y><W><F><A><P><C><S><K><M><G><K><I><M><R><G><P><F><M><K><F><V><A><H><A><A><S><F><T><I><F><L><G><L><L><V><M><N><A><A><D><R><F><E><G><T><K><L><L><P><N><E><T><S><T><D><N><A><K><Q><L><F><R><M><K><T><S><C><F><S><W><M><E><M><L><I><I><S><W><V><I><G><M><I><W><A><E><C><K><E><I><W><T><Q><G><P><K><E><Y><L><F><E><L><W><N><M><L><D><F><G><M><L><A><I><F><A><A><S><F><I><A><R><F><M><A><F><W><H><A><S><K><A><Q><S><I><I><D><A><N><D><T><L><K><D><L><T><K><V><T><L><G><D><N><V><K><Y><Y><N><L><A><R><I><K><W><D><P><S><D><P><Q><I><I><S><E><G><L><Y><A><I><A><V><V><L><S><F><S><R><I><A><Y><I><L><P><A><N><E><S><F><G><P><L><Q><I><S><L><G><R><T><V><K><D><I><F><K><F><M><V><I><F><I><M><V><F><V><A><F><M><I><G><M><F><N><L><Y><S><Y><Y><I><G><A><K><Q><N><E><A><F><T><T><V><E><E><S><F><K><T><L><F><W><A><I><F><G><L><S><E><V><K><S><V><V><I><N><Y><N><H><K><F><I><E><N><I><G><Y><V><L><Y><G><V><Y><N><V><T><M><V><I><V><L><L><N><M><L><I><A><M><I><N><S><S><F><Q><E><I><E><D><D><A><D><V><E><W><K><F><A><R><A><K><L><W><F><S><Y><F><E><E><G><R><T><L><P><V><P><F><N><L><V><P><S><P><K><S><L><F><Y><L><L><L><K><L><K><K><W><I><S><E><L><F><Q><G><H><K><K><G><F><Q><E><D><A><E><M><N><K><I><N><E><E><K><K><L><G><I><L><G><S><H><E><D><L><S><K><L><S><L><D><K><K><Q><V><G><H><N><K><Q><P><S><I><R><S><S><E><D><F><H><L><N><S><F><N><N><P><P><R><Q><Y><Q><K><I><M><K><R><L><I><K><R><Y><V><L><Q><A><Q><I><D><K><E><S><D><E><V><N><E><G><E><L><K><E><I><K><Q><D><I><S><S><L><R><Y><E><L><L><E><E><K><S><Q><N><T><E><D><L><A><E><L><I><R><E><L><G><E><K><L><S><M><E><P><N><Q><E><E><T><N><R>
Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol. Seems not to be activated by intracellular calcium store depletion.<BOP>
Q8WXA9
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Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3.<BOP>
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