This is Protein TMA108 protein, from Baker's yeast, contains 946 amino acids, is soluble, locates in Cytoplasm.

Putative zinc aminopeptidase which may be involved in ribosome biogenesis


This is Probable secreted beta-glucosidase SIM1 protein, from Baker's yeast, contains 476 amino acids, is soluble, locates in Extracellular.

Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions, Required for the maintenance of the CLB5 kinase activity


This is Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1 protein, from Baker's yeast, contains 686 amino acids, is membrane-bound, locates in Cell membrane.

Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways, Phosphorylated and activated by TORC2 under favorable growth conditions, Mediates actin polarization via inhibition of calcineurin-dependent transcription, Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization, Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis


This is 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 protein, from Baker's yeast, contains 425 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323), In association with DPH2, transfers a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:15485916, PubMed:31463593, PubMed:34154323, PubMed:24422557, PubMed:27694803)

Belongs to the DPH1/DPH2 family, DPH1 subfamily


This is Actin-regulating kinase PRK1 protein, from Baker's yeast, contains 810 amino acids, is soluble, locates in Cytoplasm.

Protein kinase involved in the regulation of actin cytoskeleton organization and endocytosis (PubMed:9885245, PubMed:10087264, PubMed:11694597, PubMed:11739778), Phosphorylates PAN1 which disrupts the interaction between PAN1 and END3, and between PAN1 and SLA1 (PubMed:9885245, PubMed:11739778, PubMed:13679512), Phosphorylates SCD5 (PubMed:12956961, PubMed:13679512), Preferentially, phosphorylates substrates on threonine residues in a [L/I/V/M]-x-x-[Q/N/T/S]-x-T-G motif (PubMed:9885245, PubMed:11739778, PubMed:12956961, PubMed:13679512)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Vacuolar amino acid transporter 7 protein, from Baker's yeast, contains 490 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Probable amino acid transporter of unknown specificity

Belongs to the amino acid/polyamine transporter 2 family


This is Transcriptional regulatory protein SDS3 protein, from Baker's yeast, contains 327 amino acids, locates in Nucleus.

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, SDS3 is required for the HDAC activity of the complex and for the RPD3-SIN3 association


This is Mitochondrial fission 1 protein protein, from Baker's yeast, contains 155 amino acids, is membrane-bound, locates in Mitochondrion.

Has a role in mitochondrial fission, Has a role in outer membrane fission but not matrix separation, Required for targeting MDV1 to the mitochondria, Regulates the assembly of DNM1 into punctate structures, in the mitochondrial tubules, promoting mitochondrial membrane constriction and/or division


This is Ran-specific GTPase-activating protein 2 protein, from Baker's yeast, contains 327 amino acids, locates in Nucleus.

Important for the export of protein containing nuclear export signal (NES) out of the nucleus, Stimulates the GTPase activity of GSP1


This is [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial protein, from Baker's yeast, contains 394 amino acids, is soluble, locates in Mitochondrion.

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism, Also involved in telomere maintenance

Belongs to the PDK/BCKDK protein kinase family


This is ER membrane protein complex subunit 5 protein, from Baker's yeast, contains 141 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151), Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151), Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151), It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes, By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity)

Belongs to the membrane magnesium transporter (TC 1,A,67) family


This is Peroxiredoxin DOT5 protein, from Baker's yeast, contains 215 amino acids, locates in Nucleus.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events, Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes, Also has a role in the regulation of telomere length, Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth, Preferentially reduces alkyl-hydroperoxides rather than hydrogen peroxide, Acts as an antioxidant necessary for stationary phase survival

Belongs to the peroxiredoxin family, BCP/PrxQ subfamily


This is Mitochondrial nicotinamide adenine dinucleotide transporter 1 protein, from Baker's yeast, contains 373 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial inner membrane carrier protein that mediates the import of NAD(+) into mitochondria (PubMed:16291748, PubMed:32906142, PubMed:33087354), Can transport NAD(+) by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP (PubMed:16291748), Also able to transport NAD(+) by exchange with AMP, GMP or deamido-NAD (+) in vitro (PubMed:16291748)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is ER-retained PMA1-suppressing protein 1 protein, from Baker's yeast, contains 701 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acts as a membrane-bound chaperone in endoplasmic reticulum quality control, Probably facilitates presentation of substrate to membrane-bound components of the degradation machinery

Belongs to the protein disulfide isomerase family


This is Cytosolic Fe-S cluster assembly factor CFD1 protein, from Baker's yeast, contains 293 amino acids, is soluble, locates in Cytoplasm.

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:12970194, PubMed:15660135, PubMed:17401378), Required for maturation of extramitochondrial Fe-S proteins (PubMed:12970194, PubMed:15660135, PubMed:17401378, PubMed:22362766, PubMed:31040179), The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:17401378, PubMed:22362766), Nucleotide binding/hydrolysis seems to be critcal for loading of Fe-S clusters onto CFD1 and NBP35 (PubMed:22362766), Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export (PubMed:15660135)

Belongs to the Mrp/NBP35 ATP-binding proteins family, NUBP2/CFD1 subfamily


This is Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51 protein, from Baker's yeast, contains 946 amino acids, is soluble, locates in Cytoplasm.

Controls the cellular levels and subcellular distribution of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), Does not utilize phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), nor phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P), Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway, Involved in endocytosis and acts as a negative regulator of the Slm pathway which modulates polarized actin assembly and growth

In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family


This is ATP-dependent DNA helicase MPH1 protein, from Baker's yeast, contains 993 amino acids, locates in Nucleus.

ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance (PubMed:10880470, PubMed:15126389, PubMed:15634678, PubMed:16121259), Capable of unwinding D-loops (PubMed:19136626), Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair (PubMed:19136626), Prevents crossovers between ectopic sequences by removing substrates for MUS81-MMS4 or RAD1-RAD10 cleavage (PubMed:24119400), Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable) (PubMed:22912599), Binds to flap-structured DNA but not to non-flap nicked DNA, and participates in Okazaki fragment processing by stimulating the endonuclease activities of FEN1 and DNA2 (PubMed:19181670), Involved in recombination donor preference during mating-type switching via interaction with FKH1 (PubMed:27257873)

Belongs to the DEAD box helicase family, DEAH subfamily, FANCM sub-subfamily


This is Altered inheritance of mitochondria protein 21 protein, from Baker's yeast, contains 679 amino acids, is soluble, locates in Cytoplasm.

Involved in mitochondrial migration along actin filaments


This is ADP-ribosylation factor-like protein 1 protein, from Human, contains 181 amino acids, is membrane-bound, locates in Golgi apparatus.

GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159), Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells (PubMed:22981988)

Belongs to the small GTPase superfamily, Arf family


This is Protein swallow protein, from Fruit fly, contains 548 amino acids, locates in Nucleus.

Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis


This is Torso-like protein protein, from Fruit fly, contains 353 amino acids, is soluble, locates in Extracellular.

Probable ligand that binds to the torso receptor, Implicated in a receptor tyrosine kinase signaling pathway that specifies terminal cell fate


This is DNA mismatch repair protein Mlh1 protein, from Human, contains 756 amino acids, locates in Nucleus.

Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR), DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex, Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2, It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch, DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected, MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR, Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages, Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis

Belongs to the DNA mismatch repair MutL/HexB family


This is Ribosome biogenesis protein RLP7 protein, from Baker's yeast, contains 322 amino acids, locates in Nucleus.

Involved in the biogenesis of the 60S ribosomal subunit, May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs

Belongs to the universal ribosomal protein uL30 family


This is Chloride anion exchanger protein, from Human, contains 764 amino acids, is membrane-bound, locates in Cell membrane.

Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094), Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity)

Belongs to the SLC26A/SulP transporter (TC 2,A,53) family


This is MBF complex negative regulatory component yox1 protein, from Fission yeast, contains 201 amino acids, locates in Nucleus.

Negative regulatory component of the MBF transcription factor complex involved in cell-cycle G1/S phase-specific gene expression and more particularly DNA replication checkpoint-dependent gene expression


This is ADP-ribosylation factor 3 protein, from Mouse-ear cress, contains 182 amino acids, locates in Golgi apparatus.

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus


This is ADP,ATP carrier protein 2, mitochondrial protein, from Mouse-ear cress, contains 385 amino acids, is membrane-bound, locates in Mitochondrion.

ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity), Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity)


This is Chitinase 3 protein, from Yeast, contains 567 amino acids, is soluble, locates in Extracellular.

Chitinase involved in the remodeling of chitin in the fungal cell wall, Plays a role in cell separation

Belongs to the glycosyl hydrolase 18 family, Chitinase class III subfamily


This is Chitin biosynthesis protein CHS6 protein, from Baker's yeast, contains 746 amino acids, is membrane-bound, locates in Golgi apparatus.

Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3


This is Prohibitin-1 protein, from Baker's yeast, contains 287 amino acids, is membrane-bound, locates in Mitochondrion.

Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins, Has an antiproliferative activity, Regulates replicative life span


This is SUMO-conjugating enzyme ubc9 protein, from Fission yeast, contains 157 amino acids, locates in Nucleus.

Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins, Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis, This may be as part of a checkpoint independent recovery process

Belongs to the ubiquitin-conjugating enzyme family


This is RNA polymerase I-specific transcription initiation factor RRN7 protein, from Baker's yeast, contains 514 amino acids, has 1 RRN7-type Zinc finger, locates in Nucleus.

Component of RNA polymerase I core factor complex (CF) that acts as a SUA7/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription, Binds rDNA promoters and plays a role in Pol I recruitment, After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a pre-initiation complex


This is Ribonuclease MRP protein subunit SNM1 protein, from Baker's yeast, contains 198 amino acids, locates in Nucleus.

Essential component of the MRP ribonucleoprotein endoribonuclease that cleaves mitochondrial primer RNA sequences


This is Zinc finger protein on ecdysone puffs protein, from Fruit fly, contains 716 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

May play a role in the process of early and late gene activation, or possibly in RNA processing, for a defined set of developmentally regulated loci


This is Delta-type opioid receptor protein, from Human, contains 372 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling leads to the inhibition of adenylate cyclase activity, Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, Plays a role in the perception of pain and in opiate-mediated analgesia, Plays a role in developing analgesic tolerance to morphine

Belongs to the G-protein coupled receptor 1 family


This is Kappa-type opioid receptor protein, from Human, contains 380 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins, Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling leads to the inhibition of adenylate cyclase activity, Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, Plays a role in the perception of pain, Plays a role in mediating reduced physical activity upon treatment with synthetic opioids, Plays a role in the regulation of salivation in response to synthetic opioids, May play a role in arousal and regulation of autonomic and neuroendocrine functions


This is B-cell lymphoma 6 protein protein, from Human, contains 706 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions, Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes, Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors, In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155, An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response, In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells, Also required for the establishment and maintenance of immunological memory for both T- and B-cells, Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2, In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners, Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation


This is Eukaryotic translation initiation factor 2D protein, from Human, contains 584 amino acids, is soluble, locates in Cytoplasm.

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner, The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs, Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety, Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit, In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits


This is C->U-editing enzyme APOBEC-1 protein, from Human, contains 236 amino acids, is soluble, locates in Cytoplasm.

Cytidine deaminase catalyzing the cytidine to uridine postranscriptional editing of a variety of mRNAs (PubMed:30844405), Form complexes with cofactors that confer differential editing activity and selectivity, Responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the apolipoprotein B mRNA (PubMed:24916387), Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA (PubMed:11727199), May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (By similarity)

Belongs to the cytidine and deoxycytidylate deaminase family


This is Mitogen-activated protein kinase kinase kinase 8 protein, from Human, contains 467 amino acids, is soluble, locates in Cytoplasm.

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses, Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells, Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production, In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4, Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production, May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types, In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis, Plays a role in the cell cycle, Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily


This is C-C chemokine receptor type 2 protein, from Human, contains 374 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection


This is 5-demethoxyubiquinone hydroxylase, mitochondrial protein, from Baker's yeast, contains 233 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis (PubMed:16624818, PubMed:8621692, PubMed:9452453, PubMed:23940037), Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides (PubMed:16624818)


This is Maintenance of mitochondrial morphology protein 1 protein, from Baker's yeast, contains 426 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria (PubMed:19556461), Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:8089172, PubMed:9628893, PubMed:27469264), The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex, The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex (PubMed:17410204), Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (PubMed:11266455, PubMed:12454062, PubMed:14981098)


This is Large ribosomal subunit protein uL16 protein, from Baker's yeast, contains 221 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the universal ribosomal protein uL16 family


This is RNA end formation protein 2 protein, from Baker's yeast, contains 533 amino acids, locates in Nucleus.

RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, Negative regulator of poly(A) synthesis, Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation, REF2 is required for 3'-end formation of snoRNAs


This is Histone-lysine N-methyltransferase E(z) protein, from Fruit fly, contains 760 amino acids, locates in Nucleus.

Polycomb group (PcG) protein, Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene, While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state, The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily


This is Phytepsin protein, from Barley, contains 508 amino acids, locates in Lysosome/Vacuole.

Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles


This is Longitudinals lacking protein, isoform G protein, from Fruit fly, contains 891 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is Longitudinals lacking protein, isoforms H/M/V protein, from Fruit fly, contains 549 amino acids, locates in Nucleus.


This is Protein gurken protein, from Fruit fly, contains 295 amino acids, is membrane-bound, locates in Cell membrane.

Critical for defining the anterior-posterior and dorsal-ventral axes of the egg, May signal directly to dorsal follicle cells through the receptor torpedo (top), During oogenesis this signaling pathway instructs follicle cells to follow a dorsal pathway of development rather than the default ventral pathway


This is Homeobox protein Nkx-2.2 protein, from Mouse, contains 273 amino acids, locates in Nucleus.

Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (PubMed:11076772), May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance, Binds to elements within the NEUROD1 promoter (PubMed:19759004)


This is Dipeptidyl aminopeptidase-like protein 6 protein, from Human, contains 865 amino acids, is membrane-bound, locates in Cell membrane.

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798), Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354), Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821)


This is NEDD8-activating enzyme E1 regulatory subunit AXR1 protein, from Mouse-ear cress, contains 540 amino acids, locates in Nucleus.

Regulatory subunit of the dimeric ECR1-AXR1 E1 enzyme, E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP, E1 finally transfers RUB1 to the catalytic cysteine of RCE1, Plays an important role in auxin response (PubMed:8321287), Regulates the chromosomal localization of meiotic recombination by crossovers (COs) and subsequent synapsis, probably through the activation of a CRL4 complex (PubMed:25116939), Required for E3-mediated protein degradation in response to auxin, jasmonic acid and cold stress, Required for the COP1-COP10-CSN-mediated repression of photomorphogenesis in the dark (PubMed:12368504), May function redundantly with AXL1 in the RUB conjugating pathway (PubMed:17655650), Seems not to be functionally equivalent to AXL1 in vivo (PubMed:21311953)

Belongs to the ubiquitin-activating E1 family, ULA1 subfamily


This is Chaperone protein ClpD, chloroplastic protein, from Mouse-ear cress, contains 945 amino acids, is soluble, locates in Plastid.

Molecular chaperone that interact with a ClpP-like protease involved in degradation of denatured proteins in the chloroplast (PubMed:21737456), The ATPase activity of CLPD is stimulated by CLPT1 (PubMed:25149061), Has no ADPase activity (PubMed:21737456), Interacts with transit peptides with a positional preference (PubMed:21737456, PubMed:22545953), Localization of the signal sequence at the N-terminal end of a protein seems mandatory for interaction to take place (PubMed:22545953)

Belongs to the ClpA/ClpB family, ClpD subfamily


This is 3-ketoacyl-CoA thiolase, mitochondrial protein, from Human, contains 397 amino acids, locates in Mitochondrion.

In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable), Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable), Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable), Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839), Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable), Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312)

Belongs to the thiolase-like superfamily, Thiolase family


This is Cyclin-dependent kinase 4 inhibitor B protein, from Human, contains 138 amino acids, is soluble, locates in Cytoplasm.

Interacts strongly with CDK4 and CDK6, Potent inhibitor, Potential effector of TGF-beta induced cell cycle arrest

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family


This is Glutamyl-tRNA reductase 1, chloroplastic protein, from Mouse-ear cress, contains 543 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA), Probably involved in the tetrapyrrole synthesis required for the chlorophyll biosynthesis

Belongs to the glutamyl-tRNA reductase family


This is Palmitoyltransferase PFA3 protein, from Baker's yeast, contains 336 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Palmitoyltransferase specific for VAC8, Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization

Belongs to the DHHC palmitoyltransferase family, PFA3 subfamily


This is Polyphosphoinositide phosphatase protein, from Baker's yeast, contains 879 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), Major enzyme required for hyperosmotic shock-induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function, In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control, In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol 3,5-bisphosphate


This is Low affinity vacuolar monovalent cation/H(+) antiporter protein, from Baker's yeast, contains 908 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Has a role in promoting intracellular monovalent cation sequestration via the exchange of monovalent cations and especially Na(+) for hydrogen ions across the vacuolar membrane

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family


This is Mitochondrial protein import protein ZIM17 protein, from Baker's yeast, contains 174 amino acids, has 1 DNL-type Zinc finger, is membrane-bound, locates in Mitochondrion.

DNL-type

Involved in protein import into mitochondria, Acts as a Hsp70-specific chaperone that prevents self-aggregation of the matrix Hsp70 chaperones SSC1 (mtHSP70) and SSQ1, thereby maintaining their function in mitochondrial protein import and Fe/S protein biosynthesis, May act together with PAM18 as co-chaperone to facilitate recognition and folding of imported proteins by SSC1 in the mitochondrial matrix


This is Mu-type opioid receptor protein, from Mouse, contains 398 amino acids, is membrane-bound, locates in Cell membrane.

Isoform 9 is involved in morphine-induced scratching and seems to cross-activate GRPR in response to morphine


This is Endothelin-converting enzyme 1 protein, from Rat, contains 762 amino acids, is membrane-bound, locates in Cell membrane.

Converts big endothelin-1 to endothelin-1


This is T-complex protein 1 subunit theta protein, from Mouse, contains 548 amino acids, is soluble, locates in Cytoplasm.

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis, The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance, As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia, The TRiC complex plays a role in the folding of actin and tubulin


This is Mitochondrial import inner membrane translocase subunit TIM16 protein, from Baker's yeast, contains 149 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14, May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation


This is tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial protein, from Baker's yeast, contains 407 amino acids, locates in Mitochondrion.

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine, Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, Involved in mitochondrial genome maintenance


This is Nuclear receptor subfamily 2 group F member 6 protein, from Mouse, contains 390 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Transcription factor predominantly involved in transcriptional repression, Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors, Involved in modulation of hormonal responses, Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene, Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner, The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6, Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity, Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity, Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Neuronal acetylcholine receptor subunit alpha-9 protein, from Rat, contains 479 amino acids, is membrane-bound, locates in Cell membrane.

Ionotropic receptor with a probable role in the modulation of auditory stimuli, Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane, The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane, In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing, This may protect against acoustic trauma, May also regulate keratinocyte adhesion

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily, Alpha-9/CHRNA9 sub-subfamily


This is Adenylate kinase, chloroplastic protein, from Maize, contains 222 amino acids, locates in Plastid.

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP, Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism, The maize enzyme also works with CMP, albeit with 10% of the activity with AMP


This is 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 protein, from Mouse-ear cress, contains 562 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the synthesis of mevalonate, The specific precursor of all isoprenoid compounds present in plants


This is Aquaporin PIP2-1 protein, from Mouse-ear cress, contains 287 amino acids, is membrane-bound, locates in Cell membrane.

Water channel required to facilitate the transport of water across cell membrane, Probably involved in root water uptake, Its function is impaired by Hg(2+)

Belongs to the MIP/aquaporin (TC 1,A,8) family, PIP (TC 1,A,8,11) subfamily


This is Aquaporin PIP2-2 protein, from Mouse-ear cress, contains 285 amino acids, is membrane-bound, locates in Cell membrane.

Water channel required to facilitate the transport of water across cell membrane, Plays an predominant role in root water uptake process in conditions of reduced transpiration, and in osmotic fluid transport, Its function is impaired by Hg(2+), Inhibited by cytosolic acidosis which occurs during anoxia in roots


This is Serine/threonine-protein kinase SRK2G protein, from Mouse-ear cress, contains 353 amino acids, locates in Nucleus.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Receptor protein kinase TMK1 protein, from Mouse-ear cress, contains 942 amino acids, is membrane-bound, locates in Cell membrane.

Transmembrane kinase receptor (PubMed:1332795), Phosphorylates only serine and threonine residues (PubMed:8224199), Involved in auxin signal transduction and cell expansion and proliferation regulation (PubMed:23613767), Forms with ABP1 a cell surface auxin perception complex that activates ROP signaling pathways (PubMed:24578577), Required for auxin promotion of pavement cell interdigitation (PubMed:24578577), Auxin promotes the formation of the ABP1-TMK1 protein complex (PubMed:24578577)


This is Aldehyde dehydrogenase family 3 member B1 protein, from Human, contains 468 amino acids, is membrane-bound, locates in Cell membrane.

Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:17382292, PubMed:23721920), Metabolizes also benzaldehyde (PubMed:17382292), Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920), May not metabolize short chain aldehydes, Can use both NADP(+) and NAD(+) as electron acceptor (PubMed:17382292), May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292)

Belongs to the aldehyde dehydrogenase family


This is Solute carrier family 2, facilitated glucose transporter member 5 protein, from Rat, contains 502 amino acids, is membrane-bound, locates in Cell membrane.

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:26416735, PubMed:8333543, PubMed:9820812), Can mediate the uptake of deoxyglucose, but with low efficiency (PubMed:8333543), Essential for fructose uptake in the small intestine (By similarity), Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity), Required for the development of high blood pressure in response to high dietary fructose intake (By similarity)

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily


This is Enhancer of polycomb-like protein 1 protein, from Baker's yeast, contains 832 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair, Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M

Belongs to the enhancer of polycomb family


This is Bud site selection protein 27 protein, from Baker's yeast, contains 796 amino acids, is soluble, locates in Cytoplasm.

Involved in gene expression controlled by TOR kinase and nutrient signaling, May also be involved in positioning the proximal bud pole signal

Belongs to the prefoldin subunit alpha family


This is Vacuolar transporter chaperone complex subunit 2 protein, from Baker's yeast, contains 828 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Accessory subunit of the vacuolar transporter chaperone (VTC) complex, The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP, VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046), The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046), PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834), Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (PubMed:27080106), Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106), The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419), Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419)


This is 60S ribosomal subunit assembly/export protein LOC1 protein, from Baker's yeast, contains 204 amino acids, locates in Nucleus.

Required for efficient assembly and nuclear export of the 60S ribosomal subunit, Involved in asymmetric localization of ASH1 mRNA


This is MICOS complex subunit MIC19 protein, from Baker's yeast, contains 170 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Belongs to the MICOS complex subunit Mic19 family


This is N-acetyltransferase ECO1 protein, from Baker's yeast, contains 281 amino acids, has 1 CCHH-type Zinc finger, locates in Nucleus.

CCHH-type

Required for establishment of sister chromatid cohesion during S phase but not for its further maintenance during G2 or M phases or for loading the cohesin complex onto DNA, Interacts with the three known alternate replication factor C (RFC) complexes, suggesting that these complexes have essential but redundant activity in cohesion establishment, Acts by acetylating the cohesin complex component SMC3, In vitro, possesses acetyltransferase activity where it can acetylate itself and components of the cohesin complex (MCD1, IRR1 and PDS5), but is unable to acetylate histones

Belongs to the acetyltransferase family, ECO subfamily


This is Chromatin structure-remodeling complex protein RSC8 protein, from Baker's yeast, contains 557 amino acids, has 1 ZZ-type; degenerate Zinc finger, locates in Nucleus.

ZZ-type; degenerate

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is essential for mitotic growth and for repression of CHA1 expression


This is Cys-Gly metallodipeptidase DUG1 protein, from Baker's yeast, contains 481 amino acids, is soluble, locates in Cytoplasm.

Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond, Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides


This is Inner kinetochore subunit CNN1 protein, from Baker's yeast, contains 361 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:22561346), CNN1 is important for the recruitment of the outer kinetochore Ndc80 complex (PubMed:23334295)


This is Citrate synthase 3, mitochondrial protein, from Baker's yeast, contains 486 amino acids, locates in Mitochondrion.

Dual specificity mitochondrial citrate and methylcitrate synthase with similar catalytic efficiency with both acetyl-CoA and propionyl-CoA


This is Alpha-1,3/1,6-mannosyltransferase ALG2 protein, from Baker's yeast, contains 503 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate

Belongs to the glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily


This is Lysophosphatidic acid receptor 6 protein, from Human, contains 344 amino acids, is membrane-bound, locates in Cell membrane.

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA), Intracellular cAMP is involved in the receptor activation, Important for the maintenance of hair growth and texture

Belongs to the G-protein coupled receptor 1 family


This is Protein transport protein SFT1 protein, from Baker's yeast, contains 97 amino acids, is membrane-bound, locates in Golgi apparatus.

Vesicle SNARE required for retrograde transport within the Golgi complex


This is Transcription factor GATA-4 protein, from Human, contains 442 amino acids, has 2 GATA-type Zinc finger, locates in Nucleus.

GATA-type

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466), In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724), Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression, Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity), Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity), Promotes cardiac myocyte enlargement (PubMed:20081228), Required during testicular development (PubMed:21220346), May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735)


This is Collagenase 3 protein, from Human, contains 471 amino acids, is soluble, locates in Extracellular.

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN, Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen, Can also degrade collagen type IV, type XIV and type X, May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2, Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification, Required for normal embryonic bone development and ossification, Plays a role in the healing of bone fractures via endochondral ossification, Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2, Plays a role in keratinocyte migration during wound healing, May play a role in cell migration and in tumor cell invasion


This is Palmitoyl-protein thioesterase 1 protein, from Bovine, contains 306 amino acids, locates in Lysosome/Vacuole.

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation, Prefers acyl chain lengths of 14 to 18 carbons

Belongs to the palmitoyl-protein thioesterase family


This is ATP-dependent RNA helicase ROK1 protein, from Baker's yeast, contains 564 amino acids, locates in Nucleus.

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis, Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA, May also have a gene-specific regulatory function since it affects nuclear fusion by regulating KAR4 expression and contributes with KEM1 to ISP-1 sensitivity

Belongs to the DEAD box helicase family, DDX52/ROK1 subfamily


This is Voltage-dependent anion-selective channel protein 2 protein, from Human, contains 294 amino acids, is membrane-bound, locates in Mitochondrion.

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity), The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity), The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity), Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432), Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432)

Belongs to the eukaryotic mitochondrial porin family


This is DNA-(apurinic or apyrimidinic site) endonuclease, chloroplastic protein, from Mouse-ear cress, contains 536 amino acids, is soluble, locates in Plastid.

Repairs oxidative DNA damages, seems also to act as a redox factor (PubMed:7512729), Is multifunctional and may be involved both in DNA repair and in the regulation of transcription (PubMed:7512729), Exhibits apurinic/apyrimidinic (AP) endonuclease activity (PubMed:25569774, PubMed:21781197, PubMed:25228464), Catalyzes the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH (PubMed:25228464), May be involved in base excision repair in chloroplasts (PubMed:19372224), According to a report, has a significant in vitro 3'-phosphatase activity (PubMed:25228464), According to another report, has no in vitro 3'-phosphatase activity (PubMed:25569774), Has a strong non-specific affinity to DNA (PubMed:25228464)

Belongs to the DNA repair enzymes AP/ExoA family


This is Chromobox protein homolog 5 protein, from Human, contains 191 amino acids, locates in Nucleus.

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression, In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph), Can interact with lamin-B receptor (LBR), This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane, Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins


This is Pre-mRNA polyadenylation factor FIP1 protein, from Baker's yeast, contains 327 amino acids, locates in Nucleus.

Polymerase-regulating component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase PAP1, This inhibits the extension of an oligo(A) primer by limiting access of the RNA substrate to the C-terminal RNA binding domain of PAP1, Seems to tether PAP1 to the cleavage factor I


This is Protein NRT1/ PTR FAMILY 8.3 protein, from Mouse-ear cress, contains 585 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Peptide transporter, Mediates the transport of di- and tripeptides, High affinity, low capacity transporter, Can also transport histidine

Belongs to the major facilitator superfamily, Proton-dependent oligopeptide transporter (POT/PTR) (TC 2,A,17) family


This is ATP-dependent DNA helicase Q1 protein, from Human, contains 649 amino acids, locates in Nucleus.

DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens, Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction

Belongs to the helicase family, RecQ subfamily


This is Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase protein, from Human, contains 812 amino acids, locates in Nucleus.

Involved in ribosomal large subunit assembly (PubMed:24120868), S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable), May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable)

Belongs to the class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family


This is Dipeptidyl aminopeptidase-like protein 6 protein, from Rat, contains 859 amino acids, is membrane-bound, locates in Cell membrane.

Promotes cell surface expression of the potassium channel KCND2 (PubMed:12575952), Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:12575952, PubMed:16123112, PubMed:19279261, PubMed:19901547), Has no dipeptidyl aminopeptidase activity (By similarity)


This is Glutamate--cysteine ligase, chloroplastic protein, from Mouse-ear cress, contains 522 amino acids, locates in Plastid.

Seems to play an important role in controlling the expression of resistance responses like the regulation of salicylic acid (SA) and phytoalexin (camalexin) production, Involved in resistance to fungal and bacterial pathogens, Required for the regulation of cell proliferation in root apical meristems through the GSH-dependent developmental pathway, Also participates in the detoxification process, the antioxidant response and is essential for embryo development and proper seed maturation

Belongs to the carboxylate-amine ligase family, Glutamate--cysteine ligase type 2 subfamily


This is sn-2 acyl-lipid omega-3 desaturase (ferredoxin), chloroplastic protein, from Mouse-ear cress, contains 446 amino acids, is membrane-bound, locates in Plastid.

Chloroplast omega-3 fatty acid desaturase introduces the third double bond in the biosynthesis of 16:3 and 18:3 fatty acids, important constituents of plant membranes, It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol

Belongs to the fatty acid desaturase type 1 family


This is Omega-6 fatty acid desaturase, chloroplastic protein, from Mouse-ear cress, contains 448 amino acids, is membrane-bound, locates in Plastid.

Chloroplast omega-6 fatty acid desaturase introduces the second double bond in the biosynthesis of 16:3 and 18:3 fatty acids, important constituents of plant membranes, It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol


This is Delta(12)-fatty-acid desaturase protein, from Mouse-ear cress, contains 383 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

ER (microsomal) omega-6 fatty acid desaturase introduces the second double bond in the biosynthesis of 18:3 fatty acids, important constituents of plant membranes (PubMed:14593172, PubMed:7907506), Delta(12)-desaturase with regioselectivity determined by the double bond (delta(9) position) and carboxyl group of the substrate, Can use both 16:1 and 18:1 fatty acids as substrates (PubMed:8685264), It is thought to use cytochrome b5 as an electron donor and to act on fatty acids esterified to phosphatidylcholine (PC) and, possibly, other phospholipids (PubMed:14593172, PubMed:7907506, PubMed:1730697), Very low constitutive hydroxylation activity (PubMed:11864983), Required for desaturation of fatty acids present in extraplastidial membranes, including mitochondria (PubMed:11104757, PubMed:17507388), Required for salt tolerance during seed germination and early seedling growth (PubMed:22279586)


This is Protein arginine N-methyltransferase 5 protein, from Caenorhabditis elegans, contains 734 amino acids, locates in Nucleus.

Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1 (PubMed:19521535, PubMed:21531333, PubMed:23866019, PubMed:22143770, PubMed:28158808), Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group (PubMed:23866019), Plays a role in the negative regulation of DNA damage-induced apoptosis (PubMed:19521535), By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell death activator egl-1 (PubMed:19521535), Plays a role in heat and oxidative stress resistance (PubMed:28158808)

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family


This is Pyruvate kinase protein, from Yeast, contains 504 amino acids, is soluble, locates in Cytoplasm.


This is Arginase 1, mitochondrial protein, from Mouse-ear cress, contains 342 amino acids, locates in Mitochondrion.

Catalyzes the hydrolysis of L-arginine to urea and L-ornithine (Probable), The latter can be utilized in the urea cycle or as a precursor for the synthesis of both polyamines and proline (Probable), Possesses agmatinase activity, Catalyzes the formation of putrescine from agmatine (PubMed:28716421)


This is Aspartate aminotransferase, mitochondrial protein, from Mouse-ear cress, contains 430 amino acids, is soluble, locates in Mitochondrion.

Amino acid aminotransferase important for the metabolism of amino acids and Krebs-cycle related organic acids, No activity with D-Asp or D-Ala as amino donors, In plants, it is involved in nitrogen metabolism and in aspects of carbon and energy metabolism

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is Aspartate aminotransferase 3, chloroplastic protein, from Mouse-ear cress, contains 449 amino acids, locates in Plastid.


This is DNA-directed RNA polymerase I subunit RPA43 protein, from Baker's yeast, contains 326 amino acids, locates in Nucleus.

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors, Besides, RNA polymerase I has intrinsic RNA cleavage activity, Through its association with RRN3 is involved in recruitment of Pol I to rDNA promoters, In vitro, the A13-A43 subcomplex binds single-stranded RNA

Belongs to the eukaryotic RPA43 RNA polymerase subunit family


This is tRNA-aminoacylation cofactor ARC1 protein, from Baker's yeast, contains 376 amino acids, is soluble, locates in Cytoplasm.

Binds to tRNA and functions as a cofactor for the methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS), Forms a complex with MetRS and GluRS and increases their affinity for cognate tRNAs due to the presence of a tRNA binding domain in its middle and C-terminal part, Binds specifically G4 quadruplex nucleic acid structures (these are four-stranded right-handed helices, stabilized by guanine base quartets), Also required for cytoplasmic confinement of the synthetases and tRNA

Belongs to the tRNA-aminoacylation cofactor ARC1 family


This is D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 protein, from Baker's yeast, contains 530 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate, Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate (PubMed:26774271), In addition to its enzymatic role it could play an important role in the yeast cell morphology (PubMed:10509019)

Belongs to the FAD-binding oxidoreductase/transferase type 4 family


This is Solute carrier organic anion transporter family member 1A1 protein, from Rat, contains 670 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:19129463), Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (By similarity), Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463), Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463)

Belongs to the organo anion transporter (TC 2,A,60) family


This is Small ribosomal subunit protein uS4 protein, from Human, contains 194 amino acids, is soluble, locates in Cytoplasm.

Component of the small ribosomal subunit (PubMed:23636399), The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Belongs to the universal ribosomal protein uS4 family


This is tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 protein, from Baker's yeast, contains 383 amino acids, locates in Nucleus.

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:10779558, PubMed:9851972), GCD14 is also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency (PubMed:9539420)

Belongs to the class I-like SAM-binding methyltransferase superfamily, TRM61 family


This is CTD kinase subunit beta protein, from Baker's yeast, contains 323 amino acids, locates in Nucleus.

Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated, CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats, Involved in RNA polymerase II transcriptional elongation, and as part of the CTDK-I complex, pre-mRNA 3'-end processing and SET2 mediated H3K36 methylation, Together with CTK3, required for CTK1 CTD kinase activation, Required for DNA damage induced transcription, Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose, Required for the integrity of the rDNA locus


This is EKC/KEOPS complex subunit GON7 protein, from Baker's yeast, contains 123 amino acids, locates in Nucleus.

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine, The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex, The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation, The complex is required for efficient recruitment of transcriptional coactivators


This is Probable alpha-1,6-mannosyltransferase MNN11 protein, from Baker's yeast, contains 422 amino acids, is membrane-bound, locates in Golgi apparatus.

The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins

Belongs to the glycosyltransferase 34 family


This is Cell wall mannoprotein CIS3 protein, from Baker's yeast, contains 227 amino acids, is soluble, locates in Extracellular.

Component of the outer cell wall layer, Required for stability of the cell wall and for optimal growth, Required for resistance against several antifungal and cell wall-perturbing agents


This is SPS-sensor serine protease component SSY5 protein, from Baker's yeast, contains 699 amino acids, is membrane-bound, locates in Cell membrane.

Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2, Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs, SSY5 binds as an inactive protease complex to STP1, In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1


This is DNA-directed RNA polymerase I subunit RPA34 protein, from Baker's yeast, contains 233 amino acids, locates in Nucleus.

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors, Besides, RNA polymerase I has intrinsic RNA cleavage activity, The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I

Belongs to the eukaryotic RPA34 RNA polymerase subunit family


This is Glycogenin-2 protein, from Baker's yeast, contains 380 amino acids, is soluble, locates in Cytoplasm.

Self-glucosylating initiator of glycogen synthesis, Catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues, These chains act as primers for the elongation reaction catalyzed by glycogen synthase, Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives

Belongs to the glycosyltransferase 8 family, Glycogenin subfamily


This is Mitochondrial division protein 1 protein, from Baker's yeast, contains 714 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in mitochondrial fission, Has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes, Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division

Belongs to the WD repeat MDV1/CAF4 family


This is GPI-anchored wall transfer protein 1 protein, from Baker's yeast, contains 490 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor, Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins


This is DNA replication regulator DPB11 protein, from Baker's yeast, contains 764 amino acids, locates in Nucleus.

Has a role in the initiation of DNA replication, Required at S-phase checkpoint, Required for the association of PSF1 with origins, Also required for the proper activation of RAD53 in response to DNA damage and replication blocks, Multicopy suppressor of DPB2 mutation, Overexpression restores the growth defect conferred by POL2 mutation


This is Protein PRY1 protein, from Baker's yeast, contains 299 amino acids, is soluble, locates in Extracellular.

Secreted protein required for efficient export of lipids such as acetylated sterols, Acts in detoxification of hydrophobic compounds


This is Mitochondrial import inner membrane translocase subunit TIM54 protein, from Baker's yeast, contains 478 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force, Its precise function within the TIM22 complex is unclear


This is Vacuolar transporter chaperone complex subunit 4 protein, from Baker's yeast, contains 721 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Catalytic subunit of the vacuolar transporter chaperone (VTC) complex, The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP, VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046), The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046), PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834), The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419, PubMed:12584253), Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419), Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules, Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106), The VTC complex is required for microautophagy, It is a constituent of autophagic tubes and is required for scission of microautophagic vesicles from these tubes (PubMed:17079729)


This is DNA-directed RNA polymerase III subunit RPC9 protein, from Baker's yeast, contains 161 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs, The RPC25/RPC8-RPC17/RPC9 subcomplex may bind Pol III transcripts emerging from the adjacent exit pore during elongation

Belongs to the eukaryotic RPC9 RNA polymerase subunit family


This is Nucleolar protein 9 protein, from Baker's yeast, contains 666 amino acids, locates in Nucleus.

RNA-binding nucleolar protein required for pre-rRNA processing, Component of the 90S pre-ribosome involved in production of 18S rRNA and assembly of small ribosomal subunit, Component of the pre-40S ribosome required for release from the nucleolus


This is U3 small nucleolar RNA-associated protein MPP10 protein, from Baker's yeast, contains 593 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing


This is Low affinity K(+) transporter 1 protein, from Baker's yeast, contains 497 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Low affinity potassium transporter that, with PRM6/KCH2, participates in high-affinity Ca(2+) influx system (HACS) activation during the response to mating pheromone (PubMed:21252230, PubMed:23204190), Directly promotes K(+) influx and HACS may electrochemically respond to this K(+) influx (PubMed:23204190), KCH1 and KCH2 act at the apex of the calcium signaling pathway that is used for survival during prolonged exposures to mating pheromones (PubMed:23204190)

Belongs to the KCH1 low affinity K(+) transporter family


This is GPN-loop GTPase 1 protein, from Baker's yeast, contains 385 amino acids, is soluble, locates in Cytoplasm.

Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21844196), May act at an RNAP assembly step prior to nuclear import (PubMed:23267056), Promotes sister chromatid separation during anaphase (PubMed:21532343)


This is Putative glycosyltransferase HOC1 protein, from Baker's yeast, contains 396 amino acids, is membrane-bound, locates in Golgi apparatus.

Belongs to the glycosyltransferase 32 family


This is Chromatin modification-related protein EAF6 protein, from Baker's yeast, contains 113 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair, Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3, Recruitment of NuA3 to nucleosomes requires methylated histone H3, In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation


This is Putative transferase CAF17, mitochondrial protein, from Baker's yeast, contains 497 amino acids, is soluble, locates in Mitochondrion.

Required for lysine and glutamate prototrophy and mitochondrial genome maintenance, Has a role in the maturation of mitochondrial aconitase-type and radical-SAM Fe/S proteins biotin synthase and lipoic acid synthase

Belongs to the GcvT family, CAF17 subfamily


This is Branched-chain-amino-acid aminotransferase, cytosolic protein, from Baker's yeast, contains 376 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine, Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as well as lysine and proline as the amino donors, Involved in cell cycle regulation

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family


This is Paired box protein Pax-7 protein, from Mouse, contains 503 amino acids, locates in Nucleus.

Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration


This is Receptor-like protein kinase 5 protein, from Mouse-ear cress, contains 999 amino acids, is membrane-bound, locates in Cell membrane.

Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates that controls floral organ abscission, May interact with the 'INFLORESCENCE DEFICIENT IN ABSCISSION' (IDA) ligands family

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Mediator of RNA polymerase II transcription subunit 21 protein, from Baker's yeast, contains 140 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 21 family


This is Glucagon receptor protein, from Human, contains 477 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis, Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis, Plays an important role in mediating the responses to fasting, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Promotes activation of adenylate cyclase, Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system

Belongs to the G-protein coupled receptor 2 family


This is Interleukin-11 protein, from Mouse, contains 199 amino acids, is soluble, locates in Extracellular.

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282), Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262), Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300), Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262), The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (By similarity)


This is Glutamine--tRNA ligase protein, from Human, contains 775 amino acids, is soluble, locates in Cytoplasm.

Glutamine--tRNA ligase (PubMed:26869582), Plays a critical role in brain development (PubMed:24656866)

Belongs to the class-I aminoacyl-tRNA synthetase family


This is Bifunctional riboflavin biosynthesis protein RIBA 1, chloroplastic protein, from Mouse-ear cress, contains 543 amino acids, locates in Plastid.

Involved in riboflavin biosynthesis, Catalyzes both the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate and the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate, RIBA2 and RIBA3 together are not able to complement the loss of function of RIBA1

In the C-terminal section; belongs to the GTP cyclohydrolase II family


This is Thioredoxin-1 protein, from Fruit fly, contains 107 amino acids, locates in Nucleus.

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions, As a reducing substrate of peroxiredoxin 1, thioredoxin 2 is preferred over thioredoxin 1, Required for female meiosis and early embryonic development


This is Septin homolog spn3 protein, from Fission yeast, contains 412 amino acids, is soluble, locates in Cytoplasm.

Plays a role in the cell cycle, Involved in a late stage of septum formation leading to the separation of the daughter cells

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family


This is Septin homolog spn4 protein, from Fission yeast, contains 380 amino acids, is soluble, locates in Cytoplasm.


This is NADP-dependent malic enzyme protein, from Human, contains 572 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate


This is Acetylcholine receptor subunit alpha-type acr-16 protein, from Caenorhabditis elegans, contains 498 amino acids, is membrane-bound, locates in Cell membrane.

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity), A subunit of the levamisole-insensitive nicotinic receptor

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily


This is Acetylcholine receptor subunit beta-type unc-29 protein, from Caenorhabditis elegans, contains 493 amino acids, is membrane-bound, locates in Cell membrane.

Non-alpha subunit of nicotinic acetylcholine receptor (nAChR), Involved in nAChR sensitivity to nicotine and levasimole


This is Mitochondrial group I intron splicing factor CCM1 protein, from Baker's yeast, contains 864 amino acids, locates in Mitochondrion.

RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts, Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome


This is Transcription factor RFX3 protein, from Mouse, contains 749 amino acids, locates in Nucleus.

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development, Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis, Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells (PubMed:15121860, PubMed:19671664), Also required for ciliated ependymal cell differentiation (PubMed:16930429), Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells (PubMed:17229940), Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (By similarity), Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5), Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells


This is Nonsense-mediated mRNA decay protein 3 protein, from Baker's yeast, contains 387 amino acids, locates in Nucleus.

Involved in nonsense-mediated decay of mRNAs containing premature stop codons


This is Transcription factor SOX-2 protein, from Chicken, contains 315 amino acids, locates in Nucleus.

Transcriptional activator (PubMed:7628452), Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3' (PubMed:7628452), In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens (PubMed:7628452), Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity), Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (PubMed:14517545), May function as a switch in neuronal development (PubMed:7748786)


This is Transcription factor SOX-2 protein, from Mouse, contains 319 amino acids, locates in Nucleus.

Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285), Binds to the proximal enhancer region of NANOG (PubMed:15863505), Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity), Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669), Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity), May function as a switch in neuronal development (By similarity)


This is Prospero homeobox protein 1 protein, from Mouse, contains 737 amino acids, locates in Nucleus.

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs, Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system, Involved in the regulation of the circadian rhythm, Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3

Belongs to the Prospero homeodomain family


This is Biotin--protein ligase protein, from Baker's yeast, contains 690 amino acids, is soluble, locates in Cytoplasm.

Post-translational modification of specific protein by attachment of biotin, Acts on various carboxylases such as acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase

Belongs to the biotin--protein ligase family


This is Lanosterol synthase protein, from Human, contains 732 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Key enzyme in the cholesterol biosynthesis pathway, Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:7639730, PubMed:26200341), Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341)

Belongs to the terpene cyclase/mutase family


This is Ubiquitin ligase-binding protein BUL1 protein, from Baker's yeast, contains 976 amino acids, is soluble, locates in Cytoplasm.

Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1, The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2


This is Serine/threonine-protein phosphatase PP-X isozyme 1 protein, from Mouse-ear cress, contains 305 amino acids, is soluble, locates in Plastid.

Belongs to the PPP phosphatase family, PP-4 (PP-X) subfamily


This is Poly(A) RNA polymerase protein 1 protein, from Baker's yeast, contains 642 amino acids, locates in Nucleus.

Catalytic subunit of the TRAMP5 complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information, Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met, Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome, TRF5 is also required for proper nuclear division in mitosis and sister chromatid cohesion, Involved in the regulation of histone mRNA levels, May mediate mitotic chromosome condensation

Belongs to the DNA polymerase type-B-like family


This is Serpin B4 protein, from Human, contains 390 amino acids, is soluble, locates in Cytoplasm.

May act as a protease inhibitor to modulate the host immune response against tumor cells

Belongs to the serpin family, Ov-serpin subfamily


This is T-complex protein 1 subunit epsilon protein, from Human, contains 541 amino acids, is soluble, locates in Cytoplasm.

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444), The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444), As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638), The TRiC complex plays a role in the folding of actin and tubulin (Probable)


This is Mannan-binding lectin serine protease 1 protein, from Human, contains 699 amino acids, is soluble, locates in Extracellular.

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them, The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2, Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction, Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5, Also plays a role in development (PubMed:21258343)


This is Sodium/hydrogen exchanger 3 protein, from Human, contains 834 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane Na(+)/H(+) antiporter (PubMed:26358773, PubMed:35613257, PubMed:18829453), Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity), Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:26358773, PubMed:24622516)

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2,A,36) family


This is High-affinity glutamine permease protein, from Baker's yeast, contains 663 amino acids, is membrane-bound, locates in Mitochondrion.

High affinity transport of glutamine, Also transports Leu, Ser, Thr, Cys, Met and Asn

Belongs to the amino acid-polyamine-organocation (APC) superfamily, YAT (TC 2,A,3,10) family


This is Polyunsaturated fatty acid 5-lipoxygenase protein, from Mouse, contains 674 amino acids, locates in Cytoplasm.

Catalyzes the oxygenation of arachidonate to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis of leukotrienes, which are potent mediators of inflammation (PubMed:7629107, PubMed:7809134, PubMed:7969451, PubMed:23246375, PubMed:31642348), Also catalyzes the oxygenation of arachidonic acid into 8-hydroperoxyicosatetraenoic acid (8-HPETE) and 12-hydroperoxyicosatetraenoic acid (12-HPETE) (PubMed:23246375), Displays lipoxin synthase activity being able to convert (15S)-HETE into a conjugate tetraene (By similarity), Although arachidonate is the preferred substrate, this enzyme can also metabolize oxidized fatty acids derived from arachidonate such as (15S)-HETE, eicosapentaenoate (EPA) such as (18R)- and (18S)-HEPE or docosahexaenoate (DHA) which lead to the formation of specialized pro-resolving mediators (SPM) lipoxin and resolvins E and D respectively, therefore it participates in anti-inflammatory responses (PubMed:31642348), Oxidation of DHA directly inhibits endothelial cell proliferation and sprouting angiogenesis via peroxisome proliferator-activated receptor gamma (PPARgamma)(PubMed:21307302), It does not catalyze the oxygenation of linoleic acid and does not convert (5S)-HETE to lipoxin isomers (PubMed:31642348), In addition to inflammatory processes, participates in dendritic cell migration, wound healing through an antioxidant mechanism based on heme oxygenase-1 (HO-1) regulation expression, monocyte adhesion to the endothelium via ITGAM expression on monocytes (PubMed:24226420, PubMed:23720274, PubMed:17392829, PubMed:28965882), Moreover, it helps establish an adaptive humoral immunity by regulating primary resting B cells and follicular helper T cells and participates in the CD40-induced production of reactive oxygen species (ROS) after CD40 ligation in B cells through interaction with PIK3R1 that bridges ALOX5 with CD40 (PubMed:21224059), May also play a role in glucose homeostasis, regulation of insulin secretion and palmitic acid-induced insulin resistance via AMPK (PubMed:28694473, PubMed:18421434), Can regulate bone mineralization and fat cell differentiation increases in induced pluripotent stem cells (PubMed:24906289)