This is Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 protein, from Human, contains 370 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity), Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524), Acts in concert with an unknown phospholipase A1 to convert palmitate phosphatidylethanolamine (PE) species into stearate ones, Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (By similarity), Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (PubMed:15485873), Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (By similarity), Has no activity toward lysophosphatidic acids (LPA) (By similarity)

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is ER degradation-enhancing alpha-mannosidase-like protein 1 protein, from Human, contains 657 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle, It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L, It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2

Belongs to the glycosyl hydrolase 47 family


This is La-related protein 4B protein, from Human, contains 738 amino acids, is soluble, locates in Cytoplasm.


This is Putative high affinity immunoglobulin gamma Fc receptor IB protein, from Human, contains 280 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A, May function in the humoral immune response

Belongs to the immunoglobulin superfamily, FCGR1 family


This is Small ribosomal subunit protein mS31 protein, from Human, contains 395 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mS31 family


This is DNA repair and recombination protein RAD54-like protein, from Human, contains 747 amino acids, locates in Nucleus.

Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:9774452, PubMed:24798879, PubMed:32457312, PubMed:11459989, PubMed:12205100, PubMed:27264870), Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism, Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized, Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity)

Belongs to the SNF2/RAD54 helicase family


This is Estrogen receptor beta protein, from Human, contains 530 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is Proline-rich protein PRCC protein, from Human, contains 491 amino acids, locates in Nucleus.

May regulate cell cycle progression through interaction with MAD2L2


This is Retinol dehydrogenase 5 protein, from Human, contains 318 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:11675386, PubMed:10588954, PubMed:9931293, PubMed:9115228), Has no activity towards all-trans retinal (By similarity), Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE), Also recognizes steroids (androsterone, androstanediol) as its substrates (PubMed:9931293, PubMed:29541409)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Histone-lysine N-methyltransferase EZH1 protein, from Human, contains 747 amino acids, locates in Nucleus.

Polycomb group (PcG) protein, Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene, Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively, Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity, Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily


This is TATA-binding protein-associated factor 2N protein, from Human, contains 592 amino acids, has 1 RanBP2-type Zinc finger, locates in Cytoplasm.

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters, Can enter the preinitiation complex together with the RNA polymerase II (Pol II)


This is Golgin subfamily A member 1 protein, from Human, contains 767 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in vesicular trafficking at the Golgi apparatus level, Involved in endosome-to-Golgi trafficking


This is Histone acetyltransferase KAT2A protein, from Human, contains 837 amino acids, locates in Nucleus.

(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat, Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes

Belongs to the acetyltransferase family, GCN5 subfamily


This is Probable ATP-dependent RNA helicase DDX17 protein, from Human, contains 729 amino acids, locates in Nucleus.

As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis, Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation, Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867), For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182), This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867), Affects NFAT5 and histone macro-H2A,1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867), In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867), Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2, By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493), In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439), In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784), Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491), Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153), May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity), Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491), Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482), Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701), Enhances NFAT5 transcriptional activity (PubMed:22266867), Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069), May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766), Coactivates MMP7 transcription (PubMed:17226766), Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760), Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription, This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439), During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439), Plays a role in estrogen and testosterone signaling pathway at several levels, Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069), Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493), Plays a role in innate immunity, Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784), Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784), Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637)

Belongs to the DEAD box helicase family, DDX5/DBP2 subfamily


This is Bcl-2-like protein 2 protein, from Human, contains 193 amino acids, is membrane-bound, locates in Mitochondrion.

Promotes cell survival, Blocks dexamethasone-induced apoptosis, Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX


This is Semaphorin-4D protein, from Human, contains 862 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282), Regulates GABAergic synapse development (By similarity), Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity), Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569), Promotes the migration of cerebellar granule cells (PubMed:16055703), Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214), Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703)


This is Transcription factor GATA-6 protein, from Human, contains 595 amino acids, has 2 GATA-type Zinc finger, locates in Nucleus.

GATA-type

GATA-type

Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924), Regulates SEMA3C and PLXNA2 (PubMed:19666519), Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713), May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778), Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity), Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity), In human skin, controls several physiological processes contributing to homeostasis of the upper pilosebaceous unit, Triggers ductal and sebaceous differentiation as well as limits cell proliferation and lipid production to prevent hyperseborrhoea, Mediates the effects of retinoic acid on sebocyte proliferation, differentiation and lipid production, Also contributes to immune regulation of sebocytes and antimicrobial responses by modulating the expression of anti-inflammatory genes such as IL10 and pro-inflammatory genes such as IL6, TLR2, TLR4, and IFNG, Activates TGFB1 signaling which controls the interfollicular epidermis fate (PubMed:33082341)


This is Peroxisomal membrane protein PEX13 protein, from Human, contains 403 amino acids, is membrane-bound, locates in Peroxisome.

Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:8858165, PubMed:28765278), The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity), Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:9653144, PubMed:8858165, PubMed:28765278), Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:9653144, PubMed:8858165)


This is Ribosomal RNA small subunit methyltransferase NEP1 protein, from Human, contains 244 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA, Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA, Is not able to methylate uridine at this position (PubMed:20047967), Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Belongs to the class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase NEP1 family


This is Polyribonucleotide 5'-hydroxyl-kinase Clp1 protein, from Human, contains 425 amino acids, locates in Nucleus.

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids, dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component, Plays a key role in both tRNA splicing and mRNA 3'-end formation, Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810), Its role in tRNA splicing and maturation is required for cerebellar development (PubMed:24766809, PubMed:24766810), Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation, Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC), However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing

Belongs to the Clp1 family, Clp1 subfamily


This is N-alpha-acetyltransferase 80 protein, from Human, contains 286 amino acids, is soluble, locates in Cytoplasm.

N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:30028079, PubMed:29581253), N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253), In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:30028079, PubMed:29581253), In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307), May act as a tumor suppressor (PubMed:10644992)


This is Zinc metalloproteinase nas-37 protein, from Caenorhabditis elegans, contains 765 amino acids, is soluble, locates in Extracellular.

Metalloprotease (By similarity), Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed (PubMed:15255192), Required during ecdysis, the opening of the cuticle to allow the worm to escape (PubMed:15539494)


This is Homeobox protein ceh-37 protein, from Caenorhabditis elegans, contains 278 amino acids, locates in Nucleus.

Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1,5 repeats for binding, Bends telomeric DNA and may provide chromosome stability, Also required for development of AWB olfactory neurons


This is B lymphocyte-induced maturation protein 1 homolog protein, from Caenorhabditis elegans, contains 817 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger, locates in Nucleus.

C2H2-type 5; degenerate

Transcription factor which binds to enhancer elements in the promoter region of genes (PubMed:26234645), Regulates the expression of the transcription factor bed-3 to control vulval development (PubMed:26234645, PubMed:32417234), Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage (PubMed:24613396), Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning (PubMed:24968003), Plays a role in male tail tip morphogenesis (PubMed:21408209)


This is Nose resistant to fluoxetine protein 5 protein, from Caenorhabditis elegans, contains 551 amino acids, is soluble, locates in Extracellular.

Plays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues, Possesses lipid transfer activity, Mediates transport of lipids from intestine to reproductive tract, Binds phosphatidylserine, Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells, Vital for embryonic development

Belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family


This is UDP-galactose/UDP-N-acetylglucosamine transporter srf-3 protein, from Caenorhabditis elegans, contains 368 amino acids, is membrane-bound, locates in Golgi apparatus.

Acts as a transporter of both UDP-galactose and UDP-N-acetylglucosamine into the Golgi lumen (PubMed:15123614, PubMed:15452127), Apparently transports UDP-galactose and UDP-N-acetylglucosamine simultaneously, and independently, by an unknown mechanism (PubMed:17652078), Functions redundantly with nucleotide sugar transporter nstp-4 (PubMed:17652078), May be involved in gonadal development (PubMed:17652078)

Belongs to the nucleotide-sugar transporter family, SLC35A subfamily


This is Guanine nucleotide-binding protein subunit gamma 2 protein, from Mouse-ear cress, contains 100 amino acids, is membrane-bound, locates in Cell membrane.

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems, The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction, Involved in the abscisic acid (ABA) and ethylene signaling pathways, Regulates basipetal transport of auxin (IAA) in roots and hypocotyls, and thus modulates root architecture (e,g, lateral root formation), The heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi probably by modulating cell wall-related genes expression; involved in resistance to Plectosphaerella cucumerina


This is Soluble inorganic pyrophosphatase 1 protein, from Mouse-ear cress, contains 212 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the irreversible hydrolysis of pyrophosphate (PPi) to phosphate, The MgPPi(2-) complex binds to the enzyme only after a free Mg(2+) ion has bound (Ref,9), No activity with glycerol-3-phosphate, glucose-6-phosphate, p-nitrophenylphosphate, ADP, NADP(+), NAD(+),NADH, NADPH or phosphoribosyl pyrophosphate as substrates (Ref,9), Controls the equilibrium of gluconeogenic reactions in the heterotrophic growth phase of early seedling establishment, Determinates the rate of cytosolic glycolysis, providing carbon for seed storage lipid accumulation (PubMed:22566496)


This is Protein FATTY ACID EXPORT 1, chloroplastic protein, from Mouse-ear cress, contains 226 amino acids, is membrane-bound, locates in Plastid.

Mediates the export of free fatty acid from the plastids, Potentially prefers palmitic acid (C16:0) over oleic acid (C18:1) and stearic acid (C18:0), Not involved in fatty acid activation, Required for biogenesis of the outer pollen cell wall, in particular for the assembly of exine and pollen coat and for the release of ketone wax components


This is CBL-interacting serine/threonine-protein kinase 23 protein, from Mouse-ear cress, contains 482 amino acids, is membrane-bound, locates in Cell membrane.

CIPK serine-threonine protein kinases interact with CBL proteins, Binding of a CBL protein to the regulatory NAF domain of CIPK protein leads to activation of the kinase in a calcium-dependent manner, Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1 in low K(+) condition, in response to calcium signaling and during the stomatal opening regulation by monitoring the turgor pressure in guard cells, In response to low nitrate concentration, phosphorylates NRT1,1, switching it from a low-affinity nitrate transporter to a high-affinity transporter, Confers tolerance to low potassium conditions, Involved in drought sensitivity and leaf transpiration

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is Protein LUTEIN DEFICIENT 5, chloroplastic protein, from Mouse-ear cress, contains 595 amino acids, is membrane-bound, locates in Plastid.

Heme-containing cytochrome P450 involved in the biosynthesis of xanthophylls, Specific for beta-ring hydroxylation of alpha- and beta-carotene, Has also a low activity toward the epsilon-rings of alpha-carotene, The beta-ring of alpha-carotene is the preferred substrate in planta


This is THO complex subunit 1 protein, from Mouse-ear cress, contains 599 amino acids, locates in Nucleus.

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, Contributes to the integrity of the endogenous trans-acting small interfering RNA (ta-siRNA) pathway, May process or transport a long RNA molecule so that it can be a template for secondary siRNA production, May participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center, Required for the generation of functional messenger ribonucleoproteins (mRNPs), Plays an important roles in plant innate immunity


This is NifU-like protein 2, chloroplastic protein, from Mouse-ear cress, contains 235 amino acids, is soluble, locates in Plastid.

Molecular scaffold for [Fe-S] cluster assembly of chloroplastic iron-sulfur proteins, Required for biogenesis of ferredoxin, a major photosynthetic electron carrier containing [2Fe-2S] cluster, Required for the assembly of photosystem I complex


This is Protein-S-isoprenylcysteine O-methyltransferase B protein, from Mouse-ear cress, contains 197 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues, resulting in the modulation of the function of prenylated proteins, Involved in negative regulation of abscisic acid signaling, Carboxyl methylation is a reversible and potentially regulated step in the post-translational modification of prenylated proteins

Belongs to the class VI-like SAM-binding methyltransferase superfamily, Isoprenylcysteine carboxyl methyltransferase family


This is Probable pectin methyltransferase QUA3 protein, from Mouse-ear cress, contains 600 amino acids, is membrane-bound, locates in Golgi apparatus.

S-adenosyl-L-methionine (SAM)-dependent methyltransferase (MTase) which mediates the methylesterification of the pectin homogalacturonan (HG) and thus regulates cell wall biosynthesis, at least in suspension-cultured cells

Belongs to the methyltransferase superfamily


This is Chlorophyll a-b binding protein CP29 protein, from Chlamydomonas smithii, contains 280 amino acids, is membrane-bound, locates in Plastid.

The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated, CP29 facilitates the State 1 to State 2 transition, where State I is induced by excess photosystem I (PSI) light and State 2 is induced by excess photosystem II (PSII) light

Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family


This is Protein SENESCENCE-ASSOCIATED GENE 21, mitochondrial protein, from Mouse-ear cress, contains 97 amino acids, locates in Mitochondrion.

Mediates tolerance to oxidative stresses (e,g, hydrogen peroxide H(2)O(2), diamide, menadione and tert-butyl hydroperoxide) by minimizing the negative effects of oxidation and monitoring photosynthesis during stress (PubMed:17092320), Promotes root development, Prevents premature aging (e,g, senescence and flowering), Involved in resistance against compatible pathogens such as Botrytis cinerea and Pseudomonas syringae pv, tomato (PubMed:21736589)


This is Two-component response regulator-like APRR7 protein, from Mouse-ear cress, contains 727 amino acids, locates in Nucleus.

Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression, Represses the expression of other clock proteins and master regulators of plant growth, development and response to abiotic stress, Involved in the positive and negative feedback loops of the circadian clock, Controls photoperiodic flowering response and temperature compensation, Expression of several members of the ARR-like family is controlled by circadian rhythm, APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight, The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock


This is ATP-dependent Clp protease ATP-binding subunit CLPT1, chloroplastic protein, from Mouse-ear cress, contains 238 amino acids, locates in Plastid.

Accessory protein regulating the assembly of the plastidial Clp protease system (PubMed:21266658, PubMed:25921872), CLPT1 first binds to the heptameric P-ring containing the CLP3-6 subunits followed by CLPT2, and only then does the P-ring combine with the R-ring composed of the clpP1 and CLPR1-4 subunits (PubMed:21266658), Once the core complex is fully assembled, it then associates to the CLPC chaperone partner to form the functional protease (PubMed:21266658), CLPT1 and CLPT2 are partially redundant (PubMed:25921872)


This is Galactolipid galactosyltransferase SFR2, chloroplastic protein, from Mouse-ear cress, contains 622 amino acids, is membrane-bound, locates in Plastid.

Glycosyl hydrolase family protein acting primarily as a highly specific galactosyltransferase (PubMed:25100720), Synthesizes digalactosyldiacylglycerol from monogalactosyldiacylglycerol in the absence of UDP-galactose in vitro (PubMed:14600212), Hydrolyzes o- and p-nitrophenyl beta-D-glucoside in vitro (PubMed:15258268), Plays a role in freezing tolerance (PubMed:15258268, PubMed:18466306, PubMed:20798281), May play a role in chloroplast protection (PubMed:18466306)

Belongs to the glycosyl hydrolase 1 family


This is Protein disulfide-isomerase SCO2 protein, from Mouse-ear cress, contains 187 amino acids, is membrane-bound, locates in Plastid.

Protein disulfide-isomerase involved in chloroplast development in cotyledons, Involved in the process of vesicle-derived thylakoid formation, probably at the level of the integration and folding of LHCB proteins at the initial location of integration, Acts only in germinating seeds after dormancy, during the transition from heterotrophic to autotrophic growth


This is (E,E)-geranyllinalool synthase protein, from Mouse-ear cress, contains 877 amino acids, is soluble, locates in Cytoplasm.

Involved in the biosynthesis of homoterpenes, attractants of herbivores parasitoids and predators (e,g, predatory mites and parasitoid wasps) (PubMed:21334702), Involved in diterpene (C20) biosynthesis (PubMed:18398052, PubMed:18842097), Catalyzes the conversion of geranylgeranyl diphosphate to (E,E)-geranyllinalool, the precursor of the insect-induced volatile C16-homoterpene TMTT (PubMed:18398052, PubMed:18842097)

Belongs to the terpene synthase family, Tpsf subfamily


This is Plastidial pyruvate kinase 3, chloroplastic protein, from Mouse-ear cress, contains 571 amino acids, is soluble, locates in Plastid.

Required for plastidial pyruvate kinase activity


This is Ent-kaurene oxidase, chloroplastic protein, from Mouse-ear cress, contains 509 amino acids, is membrane-bound, locates in Plastid.

Catalyzes three successive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid, a key step in gibberellins (GAs) biosynthesis, GAs, which are involved many processes, including stem elongation, play a central role in plant development


This is Stromal cell-derived factor 2-like protein protein, from Mouse-ear cress, contains 218 amino acids, locates in Endoplasmic reticulum.

Involved in the endoplasmic reticulum (ER) protein quality control and unfolded protein response, May be involved in the quality control of glycoproteins, Forms a complex in the ER with ERDJ3B and MED37A/BIP1 which is required for the proper accumulation and function of the surface-exposed leucine-rich repeat receptor kinases EFR involved in pathogen-associated molecular pattern (PAMP) triggered immunity


This is Peptidyl-prolyl cis-trans isomerase FKBP53 protein, from Mouse-ear cress, contains 477 amino acids, locates in Nucleus.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity), Histone chaperone possibly involved in H3/H4 deposition to the nucleosome, Associates with 18S rDNA chromatin and negatively regulates the level of its expression


This is LL-diaminopimelate aminotransferase, chloroplastic protein, from Mouse-ear cress, contains 461 amino acids, locates in Plastid.

Required for lysine biosynthesis, Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E,coli, Not active with meso-diaminopimelate, lysine or ornithine as substrates

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, LL-diaminopimelate aminotransferase subfamily


This is Protein NSP-INTERACTING KINASE 3 protein, from Mouse-ear cress, contains 632 amino acids, is membrane-bound, locates in Cell membrane.

Involved in defense response to geminivirus infection

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is La protein 1 protein, from Mouse-ear cress, contains 433 amino acids, is soluble, locates in Nucleus.

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation


This is Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A protein, from Mouse-ear cress, contains 779 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation, N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER), All subunits are required for a maximal enzyme activity, This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity), Controls adaptive responses to salt/osmotic stress, Acts as a key glycosylation determinant for EFR function during plant innate immunity (PubMed:12972670, PubMed:19763086, PubMed:19763087)


This is Transcription initiation factor TFIID subunit 12b protein, from Mouse-ear cress, contains 683 amino acids, locates in Nucleus.

TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription, Required for the expression of a subset of ethylene-responsive genes, Probably involved in the negative regulation of cytokinin sensitivity


This is Two-component response regulator ARR1 protein, from Mouse-ear cress, contains 690 amino acids, locates in Nucleus.

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3', Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system, Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes, Could directly activate some type-A response regulators in response to cytokinins, Regulates SHY2 by binding to its promoter (PubMed:19039136), Involved in the root-meristem size determination through the regulation of cell differentiation (PubMed:17363254)

Belongs to the ARR family, Type-B subfamily


This is UDP-N-acetylglucosamine diphosphorylase 1 protein, from Mouse-ear cress, contains 505 amino acids, is soluble, locates in Cytoplasm.

Uridylyltransferase involved in the biosynthesis of UDP-glucosamine, an essential precursor for glycoprotein and glycolipid synthesis, Can use both UDP-glucosamine and the 4-epimer UDP-galactosamine as substrates, but no other sugars or NTPs (PubMed:20557289), Acts redundantly with GLCNAC1PUT2, Required for gametogenesis and embryo development (PubMed:25231969)


This is La-related protein 1A protein, from Mouse-ear cress, contains 826 amino acids, is soluble, locates in Cytoplasm.

Required for acclimation and survival during thermal stress, Heat-specific cofactor of XRN4 required for its targeting to polysomes and subsequent rapid degradation of seedling transcriptome during the early steps of the heat stress response


This is Auxin efflux carrier component 7 protein, from Mouse-ear cress, contains 619 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a component of the auxin efflux carrier (PubMed:14614497, PubMed:20439545), Mediates the initial auxin gradient which contributes to the establishment of the apical-basal axis in early embryogenesis (PubMed:14614497)

Belongs to the auxin efflux carrier (TC 2,A,69,1) family


This is CLAVATA3/ESR (CLE)-related protein 44 protein, from Mouse-ear cress, contains 112 amino acids, is soluble, locates in Extracellular.

Extracellular signal peptide that regulates cell fate, May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins, Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2 (PubMed:28607033)

Belongs to the CLV3/ESR signal peptide family


This is Dynamin-A protein, from Social amoeba, contains 853 amino acids, is soluble, locates in Cytoplasm.

Function in membrane trafficking processes along the endo-lysosomal pathway

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Protein NRT1/ PTR FAMILY 2.10 protein, from Mouse-ear cress, contains 636 amino acids, is membrane-bound, locates in Cell membrane.

High-affinity, proton-dependent glucosinolate-specific transporter, Involved in the distribution of glucosinolates within the leaf, including import into the glucosinolate-rich S-cells located adjacent to the phloem, Involved in bidirectional long-distance transport of aliphatic but not indole glucosinolates, May be involved in removal of glucosinolates from the xylem in roots

Belongs to the major facilitator superfamily, Proton-dependent oligopeptide transporter (POT/PTR) (TC 2,A,17) family


This is Fructose-bisphosphate aldolase 2, chloroplastic protein, from Mouse-ear cress, contains 398 amino acids, is soluble, locates in Plastid.

Plays a key role in glycolysis and gluconeogenesis

Belongs to the class I fructose-bisphosphate aldolase family


This is Serine/threonine-protein kinase WNK8 protein, from Mouse-ear cress, contains 563 amino acids, locates in Nucleus.

Regulates flowering time by modulating the photoperiod pathway, Phosphorylates the vacuolar ATPase subunit C (VATC) and RGS1 (PubMed:16427632, PubMed:18761494), Regulates EDM2 that, in turn, modulates development processes (PubMed:20840782, PubMed:20149132)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, WNK subfamily


This is Set1/Ash2 histone methyltransferase complex subunit ASH2 protein, from Fruit fly, contains 556 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Transcriptional regulator, Regulates a number of genes involved in wing development including activation of net and bs and repression of rho and kni and controls vein-intervein patterning during wing development, Required for correct expression of a number of homeotic genes including Scr in the first leg imaginal disk and Ubx in the third leg imaginal disk and haltere disks, Required for stabilization of the histone-lysine N-methyltransferase trr and for trimethylation of 'Lys-4' of histone H3, Plays a role in maintenance of transcriptionally active chromatin through down-regulation of histone H1 hyperphosphorylation


This is Protein DETOXIFICATION 47, chloroplastic protein, from Mouse-ear cress, contains 543 amino acids, is membrane-bound, locates in Plastid.

Functions as a multidrug and toxin extrusion transporter in the export of salicylic acid (SA) from the chloroplast to the cytoplasm (PubMed:23757404), Plays an essential function in plant defense via the pathogen-induced salicylic acid (SA) accumulation (PubMed:11826312, PubMed:24594657), Acts also as a key component of the Age-related resistance (ARR) pathway (PubMed:11884688, PubMed:19694953, PubMed:24594657)

Belongs to the multi antimicrobial extrusion (MATE) (TC 2,A,66,1) family


This is NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 protein, from Mouse-ear cress, contains 117 amino acids, is membrane-bound, locates in Mitochondrion.

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis, Complex I functions in the transfer of electrons from NADH to the respiratory chain, The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity), Is required for correct plant growth and development


This is Sm-like protein LSM1A protein, from Mouse-ear cress, contains 128 amino acids, is soluble, locates in Cytoplasm.

Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by promoting decapping and leading to accurate 5'-3' mRNA decay, LSM1A and LSM1B are essential for the formation of the cytoplasmic LSM1-LSM7 complex which regulates developmental gene expression by the decapping of specific development-related transcripts (PubMed:23221597, PubMed:23620288), Required for P-body formation during heat stress (PubMed:23221597)


This is Octanoyltransferase LIP2p, chloroplastic protein, from Mouse-ear cress, contains 278 amino acids, locates in Plastid.

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) (PubMed:11602263), Together with LIP1P is essential for de novo plastidial protein lipoylation during seed development, Acts redundantly with LIP2P2 (PubMed:23581459)


This is Probable cytosolic oligopeptidase A protein, from Mouse-ear cress, contains 701 amino acids, is soluble, locates in Cytoplasm.

Oligopeptidase that may be involved in the degradation of proteasome-generated peptides (By similarity), Binds salicylic acid


This is Histone-lysine N-methyltransferase ASHR3 protein, from Mouse-ear cress, contains 497 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Histone methyltransferase (By similarity), Involved in stamen development

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily


This is Dihomomethionine N-hydroxylase protein, from Mouse-ear cress, contains 538 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the conversion of the short chain elongated methionines di-, tri-, and tetrahomomethionine to their respective aldoximes 5-methylthiopentanaldoxime, 6-methylthiohexanaldoxime, and 7-methylheptanaldoxime


This is Peroxiredoxin-2E, chloroplastic protein, from Mouse-ear cress, contains 234 amino acids, is soluble, locates in Plastid.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides (By similarity), May be involved in chloroplast redox homeostasis (Probable)

Belongs to the peroxiredoxin family, Prx5 subfamily


This is Bifunctional purple acid phosphatase 26 protein, from Mouse-ear cress, contains 475 amino acids, locates in Lysosome/Vacuole.

Metallo-phosphoesterase involved in phosphate metabolism, Acid phosphatase activity with phosphoenolpyruvate, inorganic pyrophosphate, phenyl-phosphate and p-nitrophenyl-phosphate as the most effective substrates, No activity with phytic acid, phosphocholine or bis-p-nitrophenyl-phosphate, Has a peroxidase activity at alkaline pH

Belongs to the metallophosphoesterase superfamily, Purple acid phosphatase family


This is Phosphatidate cytidylyltransferase 4, chloroplastic protein, from Mouse-ear cress, contains 391 amino acids, is membrane-bound, locates in Plastid.

May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction, Promotes the biosynthesis of plastidial phosphatidylglycerol (PG) which is required for structure and function of thylakoid membranes and, hence, for photoautotrophic growth


This is Aconitate hydratase 2, mitochondrial protein, from Mouse-ear cress, contains 995 amino acids, locates in Mitochondrion.

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, Contributes to oxidative stress tolerance (PubMed:17013749), Involved in acetate assimilation (PubMed:25061985)

Belongs to the aconitase/IPM isomerase family


This is Alpha-amylase 3, chloroplastic protein, from Mouse-ear cress, contains 887 amino acids, locates in Plastid.

Possesses endoamylolytic activity in vitro, but seems not required for breakdown of transitory starch in leaves, May be involved in the determination of the final structure of glucans by shortening long linear phospho-oligosaccharides in the chloroplast stroma, Can act on both soluble and insoluble glucan substrates to release small linear and branched malto-oligosaccharides (PubMed:24089528), Works synergistically with beta-amylase toward efficient starch degradation (PubMed:24089528), Has activity against p-nitrophenyl maltoheptaoside (BPNP-G7), amylopectin and beta-limit dextrin (PubMed:24089528), Involved in stress-induced starch degradation (PubMed:27436713)

Belongs to the glycosyl hydrolase 13 family


This is Nudix hydrolase 19, chloroplastic protein, from Mouse-ear cress, contains 438 amino acids, locates in Plastid.

mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA, The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity), Mediates the hydrolysis of some nucleoside diphosphate derivatives, Has a high affinity for NADPH compared with that for NADH (PubMed:18815383)

Belongs to the Nudix hydrolase family, NudC subfamily


This is ATP-dependent 6-phosphofructokinase 3 protein, from Mouse-ear cress, contains 489 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Belongs to the phosphofructokinase type A (PFKA) family, PPi-dependent PFK group II subfamily, Atypical ATP-dependent clade 'X' sub-subfamily


This is rRNA 2'-O-methyltransferase fibrillarin 2 protein, from Mouse-ear cress, contains 320 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (Probable), Involved in pre-rRNA processing, Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (Probable), Site specificity is provided by a guide RNA that base pairs with the substrate (Probable), Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (Probable), Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity), Acts as negative regulator of expression of immune responsive genes, including pathogenesis-related gene 1 (PR1), and of resistance against bacterial pathogen (PubMed:30307032), Binds to MED19A, a positive regulator of PR1 expression, to repress the activator activity of MED19A (PubMed:30307032), In response to the bacterial pathogen-associated molecular pattern (PAMP) elf18, associates with the long non-coding RNA (lncRNA) ELENA1 (At4g16355), and releases its repression of MED19A (PubMed:30307032), Possesses ribonuclease activity toward rRNA in vitro (PubMed:29163603), Binds phosphoinositides, phospholipids and phosphatidic acid in vitro (PubMed:29163603)

Belongs to the methyltransferase superfamily, Fibrillarin family


This is 3-isopropylmalate dehydratase large subunit, chloroplastic protein, from Mouse-ear cress, contains 509 amino acids, is soluble, locates in Plastid.

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (PubMed:19150812, PubMed:20663849), Functions in both the biosynthesis of leucine and in the methionine chain elongation pathway of aliphatic glucosinolate formation (PubMed:19597944)


This is Gamma carbonic anhydrase 3, mitochondrial protein, from Mouse-ear cress, contains 258 amino acids, is membrane-bound, locates in Mitochondrion.

Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide, Mediates complex I assembly in mitochondria and respiration (By similarity)

Belongs to the gamma-class carbonic anhydrase family


This is Protein PTST, chloroplastic protein, from Mouse-ear cress, contains 277 amino acids, is soluble, locates in Plastid.

Involved in targeting GBSS1 to the starch granule (PubMed:25710501), Was originally thought to be a carbohydrate-binding scaffold protein, but it has been shown that it is mainly found as a soluble protein and that interaction with GBSS1 is a pre-requisite for subsequent starch granule binding (PubMed:19038037, PubMed:25710501), Dissociation from starch as a function of pH, Mg(2+) concentration or redox state is not observed (PubMed:19038037), Interacts primarily with amylopectin and is required for amylose synthesis (PubMed:25710501)


This is D-lactate dehydrogenase [cytochrome], mitochondrial protein, from Mouse-ear cress, contains 567 amino acids, locates in Mitochondrion.

Catalyzes the stereospecific oxidation of D-lactate to pyruvate, Involved in the detoxification of methylglyoxal and D-lactate, but probably not involved in the metabolization of glycolate

Belongs to the FAD-binding oxidoreductase/transferase type 4 family


This is L-aspartate oxidase, chloroplastic protein, from Mouse-ear cress, contains 651 amino acids, locates in Plastid.

Catalyzes the oxidation of L-aspartate to iminoaspartate, Can complement nadB-deficient E,coli mutant, Plays a role in stomatal immunity

Belongs to the FAD-dependent oxidoreductase 2 family, NadB subfamily


This is 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, chloroplastic protein, from Mouse-ear cress, contains 466 amino acids, is soluble, locates in Plastid.

Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), Is essential for chloroplast development


This is ATP-dependent Clp protease proteolytic subunit 4, chloroplastic protein, from Mouse-ear cress, contains 292 amino acids, is soluble, locates in Plastid.

Cleaves peptides in various proteins in a process that requires ATP hydrolysis, Has a chymotrypsin-like activity, Plays a major role in the degradation of misfolded proteins (By similarity), Essential protein required for chloroplast development and integrity (PubMed:16705403, PubMed:17241447), Essential for Embryogenesis (PubMed:23548781)


This is Pre-mRNA-processing factor 19 homolog 1 protein, from Mouse-ear cress, contains 523 amino acids, locates in Nucleus.

Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair (By similarity), Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity


This is Protein MRG1 protein, from Mouse-ear cress, contains 320 amino acids, locates in Nucleus.

Chromatin remodeling factor, Acts as a 'reader' protein by binding to H3K36me3 and H3K36me3 to control histone H4 acetylation, Increases the transcriptional levels of the flowering time genes FLC and FT (PubMed:25183522, PubMed:25211338), Binds the chromatin at the FT promoter upon interaction with CO (Probable)


This is Serine hydroxymethyltransferase 2, mitochondrial protein, from Mouse-ear cress, contains 517 amino acids, locates in Mitochondrion.

Functions outside the photorespiratory pathway in catalyzing the interconversion of serine and glycine with the conversion of tetrahydrofolate (THF) into 5,10-methylene-THF


This is Beta carbonic anhydrase 4 protein, from Mouse-ear cress, contains 280 amino acids, is membrane-bound, locates in Cell membrane.

Reversible hydration of carbon dioxide, Together with BCA1, involved in the CO(2) signaling pathway which controls gas-exchange between plants and the atmosphere by modulating stomatal development and movements, Promotes water use efficiency

Belongs to the beta-class carbonic anhydrase family


This is Gamma-aminobutyrate transaminase POP2, mitochondrial protein, from Mouse-ear cress, contains 504 amino acids, locates in Mitochondrion.

Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor, but not 2-oxoglutarate, The pyruvate-dependent activity is reversible while the glyoxylate-dependent activity is irreversible, Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors, Modulates steady-state GABA levels in diploid pistil cells and the haploid pollen tube, Involved in the formation of a gradient of GABA along the pollen tube path, Involved in the maintenance of the shoot apical meristem (SAM) structure and subsequent adaxial-abaxial axis-dependent development of cotyledons and leaves (PubMed:21690177)

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family


This is Cyclin-dependent kinase inhibitor 7 protein, from Mouse-ear cress, contains 195 amino acids, is soluble, locates in Nucleus.

Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity, May target specifically CDKA-1

Belongs to the CDI family, ICK/KRP subfamily


This is Nectarin-1 protein, from Ornamental tobacco, contains 229 amino acids, is soluble, locates in Extracellular.

May interact with bacterial adhesins thereby protecting the reproductive tissues from microbial attack, Has no oxalate oxidase activity


This is THO complex subunit 4C protein, from Mouse-ear cress, contains 295 amino acids, is soluble, locates in Nucleus.

Export adapter involved in nuclear export of spliced and unspliced mRNA


This is Hydroxyproline O-galactosyltransferase HPGT1 protein, from Mouse-ear cress, contains 338 amino acids, is membrane-bound, locates in Golgi apparatus.

Possesses hydroxyproline O-galactosyltransferase activity, Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs), Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues, The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition, AGP glycans play essential roles in both vegetative and reproductive plant growth

Belongs to the glycosyltransferase 31 family


This is Ubiquitin-like-specific protease ESD4 protein, from Mouse-ear cress, contains 489 amino acids, is membrane-bound, locates in Nucleus.

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins, Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5, Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3, Acts predominantly as an isopeptidase, cleaving SUMO-conjugated proteins better than SUMO peptides, Plays an important role in the control of flowering time


This is Tocopherol cyclase, chloroplastic protein, from Mouse-ear cress, contains 488 amino acids, is soluble, locates in Plastid.

Involved in the synthesis of both tocopherols and tocotrienols (vitamin E), which presumably protect photosynthetic complexes from oxidative stress, Catalyzes the conversion of 2-methyl-6-phytyl-1,4-hydroquinone and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (DMPQ) to delta- and gamma-tocopherol respectively, Converts also 2,3-dimethyl-5-geranylgeranyl-1,4-hydroquinone (DMGQ) to gamma-tocotrienol


This is Long chain base biosynthesis protein 1 protein, from Mouse-ear cress, contains 482 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Serine palmitoyltransferase (SPT), The heterodimer formed with LCB2 constitutes the catalytic core, Involved in the regulation of the programmed cell death (PCD) signaling pathway, Plays an important role during male gametogenesis and embryogenesis

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family


This is Serine hydroxymethyltransferase 3, chloroplastic protein, from Mouse-ear cress, contains 529 amino acids, locates in Plastid.

Catalyzes the interconversion of serine and glycine and directs the hydroxymethyl moiety of serine into the metabolic network of H4PteGlu(n)-bound one-carbon units


This is Reactive Intermediate Deaminase A, chloroplastic protein, from Mouse-ear cress, contains 187 amino acids, locates in Plastid.

Hydrolyzes the Ser-derived enamine/imine product of Thr dehydratase, protecting the plastidial branched-chain aminotransferase BCAT3 (AC Q9M401) from inactivation, Involved in Ile biosynthesis


This is T-complex protein 1 subunit theta protein, from Mouse-ear cress, contains 549 amino acids, is soluble, locates in Cytoplasm.

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis, Known to play a role, in vitro, in the folding of actin and tubulin, Contributes to stem cell maintenance through its impact on transcription factors trafficking through plasmodesmata (PubMed:21868675), Probably involved in refolding translocated, partially unfolded proteins, including viral movement proteins (PubMed:21868675, PubMed:22476462)


This is Early light-induced protein 2, chloroplastic protein, from Mouse-ear cress, contains 193 amino acids, is membrane-bound, locates in Plastid.

Probably involved in the integration of pigments into the mature light-harvesting pigment-protein complexes, Light-harvesting chlorophyll (LHC) a/b-binding protein required to ensure a high rate of chlorophyll accumulation during deetiolation in continuous high light, Involved in seed germination, May fulfill a photoprotective functions, Prevents excess accumulation of free chlorophyll by inhibiting the entire chlorophyll biosynthesis pathway (e,g, 5-aminolevulinate synthesis and Mg-protoporphyrin IX chelatase activity), and hence prevent photooxidative stress


This is Rho-N domain-containing protein 1, chloroplastic protein, from Mouse-ear cress, contains 401 amino acids, locates in Plastid.

Binds to and supports processing of specific plastid RNAs, Associates via its C-terminal Rho-N domain to single stranded regions of 16S and 23S rRNAs or to rbcL mRNAs, May be involved in targeting transcripts to RNases such as RNE or RNase J


This is La-related protein 1C protein, from Mouse-ear cress, contains 523 amino acids, is soluble, locates in Cytoplasm.

Promotes leaf senescence mediated by abscisic acid (ABA), salicylic acid (SA) and jasmonic acid (MeJA), probably though the induction of expression of senescence-associated genes (SAGs) and defense-related genes


This is SUMO-conjugating enzyme UBC9 protein, from Caenorhabditis elegans, contains 166 amino acids, locates in Nucleus.

Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17, Required to sumoylate the ETS transcription factor lin-1, Polycomb protein sop-2, and intermediate filament proteins, such as ifb-1 (PubMed:15107848, PubMed:15689373, PubMed:24933177), Required for embryonic development, fertility, vulval morphogenesis, inhibition of vulval cell fates, lifespan, and neuromuscular activity (PubMed:24933177)

Belongs to the ubiquitin-conjugating enzyme family


This is Cathepsin L protein, from Fruit fly, contains 371 amino acids, locates in Lysosome/Vacuole.

Important for the overall degradation of proteins in lysosomes, Essential for adult male and female fertility, May play a role in digestion


This is Basic proline-rich protein protein, from Pig, contains 676 amino acids, is soluble, locates in Extracellular.

The parotid hormone stimulates dentinal fluid transport in teeth


This is Endonuclease G, mitochondrial protein, from Caenorhabditis elegans, contains 308 amino acids, locates in Mitochondrion.

Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation

Belongs to the DNA/RNA non-specific endonuclease family


This is Torsin-like protein protein, from Caenorhabditis elegans, contains 356 amino acids, is soluble, locates in Endoplasmic reticulum.

May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins

Belongs to the ClpA/ClpB family, Torsin subfamily


This is Serine/threonine-protein kinase zyg-8 protein, from Caenorhabditis elegans, contains 802 amino acids, is soluble, locates in Cytoplasm.

Plays a role in spindle positioning during asymmetric division of one-cell stage embryos, Affects spindle position by promoting microtubule assembly during anaphase, Plays a role in regulating thermotaxis responses in AFD thermosensory neurons (PubMed:35675262)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily


This is Protein lin-54 protein, from Caenorhabditis elegans, contains 435 amino acids, locates in Nucleus.

Synthetic multivulva class B (synMuvB) protein, SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription


This is G-protein regulator 1 protein, from Caenorhabditis elegans, contains 525 amino acids, is soluble, locates in Cytoplasm.

In the 1-cell embryo, probably together with gpr-2, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135), Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force (PubMed:12730122), Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122)


This is Cation diffusion facilitator family protein 1 protein, from Caenorhabditis elegans, contains 561 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the regulation of Pn,p cell fate determination (PubMed:12015965), Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling (PubMed:12015965), Involved in zinc transport from the intestinal lumen to the pseudocoelum (PubMed:23717214)

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is F-box-like/WD repeat-containing protein ebi protein, from Fruit fly, contains 700 amino acids, locates in Nucleus.

F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control, E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins, Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation, Required to block the S phase entry in the peripheral nervous system and central nervous system in a process that does not involve the degradation of ttk, Involved in cone cell development by preventing the transcriptional repression mediated by Su(H) on Dl, probably by participating in a E3 complex that contains sno and mediates the ubiquitination and subsequent proteasomal degradation of some component of the Su(H) repressor complex


This is Telomere-binding protein cav protein, from Fruit fly, contains 345 amino acids, locates in Nucleus.

Binds to chromosome ends in a sequence-dependent manner and is required for telomere capping


This is Putative rho GDP-dissociation inhibitor 1 protein, from Social amoeba, contains 197 amino acids, is soluble, locates in Cytoplasm.

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity), Regulates the Rac-dependent signaling pathways controlling cytokinesis, actin reorganization and the contractile vacuole, Required for efficient accumulation of cap at the cell cortex


This is D-amino-acid oxidase protein, from Caenorhabditis elegans, contains 322 amino acids, locates in Peroxisome.

Catalyzes oxidative deamination of D-amino acids, in particular D-alanine, and could be responsible for the degradation of diet-derived D-alanine in the intestine, Acts on a variety of D-amino acids with greater preference towards those with basic and aromatic groups followed by those bearing neutral groups, Has no activity against acidic D-amino acids, L-amino acids or N-methyl-L-aspartic acid, May play a role in egg-laying events and early development


This is Ectopic P granules protein 2 protein, from Caenorhabditis elegans, contains 690 amino acids, is soluble, locates in Cytoplasm.

Involved in autophagy (PubMed:20550938, PubMed:24140420, PubMed:24374177), Thought to act as an adapter protein that brings PGL granules to autophagic structures containing lgg-1 (PubMed:20550938), Association with other adapters such as sepa-1 is required for the accumulation and degradation of germ cell specific P-granules by autophagy in somatic cells (PubMed:24140420, PubMed:28806108), This ensures exclusive localization of the P-granules in germ cells (PubMed:24140420, PubMed:28806108), May also play a role in the removal of sepa-1 from somatic cells (PubMed:28806108)


This is Bromodomain-containing protein bet-1 protein, from Caenorhabditis elegans, contains 853 amino acids, locates in Nucleus.

Required for the establishment and maintenance of stable cell fate in several lineages including V5,pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants (PubMed:20181741, PubMed:24346701), Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22, Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells (PubMed:24346701), Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway (PubMed:24285704, PubMed:24349540), Involved in adult locomotion, Acts together with the sumoylation pathway to prevent muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704), May play a role in vulva development (PubMed:24349540)


This is ATP-dependent RNA helicase cgh-1 protein, from Caenorhabditis elegans, contains 430 amino acids, is soluble, locates in Cytoplasm.

Probable RNA helicase required for oocyte and sperm function, Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes

Belongs to the DEAD box helicase family, DDX6/DHH1 subfamily


This is Protein cortex protein, from Fruit fly, contains 483 amino acids, is soluble, locates in Cytoplasm.

Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17251266, PubMed:18020708), Required for the completion of meiosis in oocytes (PubMed:11252055, PubMed:10683177, PubMed:10924478, PubMed:17251266, PubMed:18020708), Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis (PubMed:17251266, PubMed:18020708), Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation (PubMed:18020708), Promotes degradation of mtrm at the oocyte-to-embryo transition (PubMed:24019759)


This is Allene oxide synthase, chloroplastic protein, from Mouse-ear cress, contains 518 amino acids, is soluble, locates in Plastid.


This is Auxin transporter protein 1 protein, from Mouse-ear cress, contains 485 amino acids, is membrane-bound, locates in Cell membrane.

Carrier protein involved in proton-driven auxin influx, Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex, Unloads auxin from the mature phloem to deliver the hormone to the root meristem via the protophloem cell files, Coordinated subcellular localization of AUX1 is regulated by a brefeldin A-sensitive (BFA) vesicle trafficking process, Involved in lateral root formation, trichoblast polarization and root hair elongation, Required for gravitropism and thigmotropism, especially in roots, by modulating responses to auxin, ethylene and cytokinins such as benzyladenine (BA), Needed for ammonium-mediated root-growth inhibition, Confers sensitivity to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D, auxin analog), and to polar auxin transport inhibitors such as N-1-naphthylphthalamic acid (NPA) and 2,3,5-triiodobenzoic acid (TIBA)

Belongs to the amino acid/polyamine transporter 2 family, Amino acid/auxin permease (AAAP) (TC 2,A,18,1) subfamily


This is Phosphoserine aminotransferase 1, chloroplastic protein, from Mouse-ear cress, contains 430 amino acids, locates in Plastid.

Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB), Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family, SerC subfamily


This is Zinc finger protein ZAT10 protein, from Mouse-ear cress, contains 227 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor involved in abiotic stress responses, Can repress the stress responsive genes DREB1A and LTI78, Probably involved in jasmonate (JA) early signaling response, May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade


This is 2-Cys peroxiredoxin BAS1, chloroplastic protein, from Mouse-ear cress, contains 266 amino acids, locates in Plastid.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides, May be an antioxidant enzyme particularly in the developing shoot and photosynthesizing leaf

Belongs to the peroxiredoxin family, AhpC/Prx1 subfamily


This is Importin subunit alpha-1 protein, from Mouse-ear cress, contains 532 amino acids, locates in Nucleus.

Binds to conventional NLS motifs with high affinity in the absence of an importin beta subunit, Mediates nuclear protein import across the nuclear envelope in vitro in the absence of exogenously added importin beta subunit (PubMed:10428841), Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation (PubMed:18836040)


This is ERBB-3 BINDING PROTEIN 1 protein, from Mouse-ear cress, contains 392 amino acids, locates in Nucleus.

Binds RNA, Associates with 28S, 18S and 5,8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA, May be involved in regulation of intermediate and late steps of rRNA processing, May be involved in ribosome assembly (By similarity), Required for expression of cell cycle genes such as CYCD3-1, RNR2A and CDKB1-1, Promotes, in a dose- and auxin-dependent manner, organ growth by stimulating both cell proliferation and expansion, via the regulation of RBR1 levels (PubMed:17024182)


This is Polycomb protein sop-2 protein, from Caenorhabditis elegans, contains 735 amino acids, locates in Nucleus.

Polycomb group (PcG) protein, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, Also required to repress expression of other genes and for localization of sor-1, Binds RNA


This is Spermosin protein, from Sea squirt, contains 388 amino acids, is soluble, locates in Extracellular.

Trypsin-like protease with a narrow substrate specificity, Preferentially hydrolyzes substrates with Pro in the P2 position and Val in the P3 position, Plays a role in fertilization


This is Protein psiA protein, from Social amoeba, contains 557 amino acids, is soluble, locates in Extracellular.

Growth factor that can induce isolated amoebae to differentiate into prespore cells

Belongs to the prespore-cell-inducing factor family


This is General transcription factor 3C polypeptide 6 protein, from Human, contains 213 amino acids, locates in Nucleus.

Involved in RNA polymerase III-mediated transcription, Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters


This is SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 protein, from Human, contains 411 amino acids, locates in Nucleus.

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology), Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner, Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex), During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity), Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs), Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells


This is Sodium-coupled neutral amino acid transporter 4 protein, from Human, contains 547 amino acids, is membrane-bound, locates in Cell membrane.

Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:11342143, PubMed:19015196, PubMed:33928121), The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11414754), Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11414754, PubMed:33928121)

Belongs to the amino acid/polyamine transporter 2 family


This is Interleukin-22 receptor subunit alpha-2 protein, from Human, contains 263 amino acids, is soluble, locates in Extracellular.

Isoform 1 may play a role in establishing and maintaining successful pregnancy

Belongs to the type II cytokine receptor family


This is Ankyrin repeat and BTB/POZ domain-containing protein 1 protein, from Human, contains 478 amino acids, is soluble, locates in Cytoplasm.

May act as a mediator of the PTEN growth-suppressive signaling pathway, May play a role in developmental processes


This is U7 snRNA-associated Sm-like protein LSm10 protein, from Human, contains 123 amino acids, locates in Nucleus.

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing, Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed, Required for cell cycle progression from G1 to S phases, Binds specifically to U7 snRNA, Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner


This is GPI transamidase component PIG-T protein, from Human, contains 578 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the GPI transamidase complex, Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates


This is F-box only protein 32 protein, from Human, contains 355 amino acids, locates in Cytoplasm.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy, Recognizes TERF1


This is DNA topoisomerase I, mitochondrial protein, from Human, contains 601 amino acids, locates in Mitochondrion.

Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand, The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)

Belongs to the type IB topoisomerase family


This is Nucleotide sugar transporter SLC35B4 protein, from Human, contains 331 amino acids, is membrane-bound, locates in Golgi apparatus.

Has UDP-GlcA:UDP-GlcNAc antiporter activity

Belongs to the nucleotide-sugar transporter family, SLC35B subfamily


This is Endonuclease 8-like 2 protein, from Human, contains 332 amino acids, has 1 FPG-type Zinc finger, locates in Nucleus.

FPG-type

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents, Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles), Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine, Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand, Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates


This is Transmembrane protein 203 protein, from Human, contains 136 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the regulation of cellular calcium homeotasis (PubMed:25996873), Required for spermatogenesis (PubMed:25996873)


This is Ubiquitin-conjugating enzyme E2 E3 protein, from Human, contains 207 amino acids, locates in Cytoplasm.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination, Participates in the regulation of transepithelial sodium transport in renal cells, May be involved in cell growth arrest


This is F-box/WD repeat-containing protein 5 protein, from Human, contains 566 amino acids, is soluble, locates in Cytoplasm.

Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes, Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication, The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression, Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2, May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway


This is tRNA modification GTPase GTPBP3, mitochondrial protein, from Human, contains 492 amino acids, locates in Mitochondrion.

GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, TrmE GTPase family


This is FAST kinase domain-containing protein 4 protein, from Human, contains 631 amino acids, locates in Mitochondrion.

Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6, May play a role in cell cycle progression (PubMed:9383053)


This is Protein FAM162A protein, from Human, contains 154 amino acids, is membrane-bound, locates in Mitochondrion.

Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785), May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785), May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity)


This is Adiponectin receptor protein 1 protein, from Human, contains 375 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337), Required for normal glucose and fat homeostasis and for maintaining a normal body weight, ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis, Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity)


This is Ras-related and estrogen-regulated growth inhibitor protein, from Human, contains 199 amino acids, is soluble, locates in Cytoplasm.

Binds GDP/GTP and possesses intrinsic GTPase activity, Has higher affinity for GDP than for GTP, In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential

Belongs to the small GTPase superfamily, Ras family


This is Janus kinase and microtubule-interacting protein 2 protein, from Human, contains 810 amino acids, locates in Golgi apparatus.


This is SOSS complex subunit B2 protein, from Human, contains 204 amino acids, locates in Nucleus.

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint, In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines, The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability, Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways

Belongs to the SOSS-B family, SOSS-B2 subfamily


This is Adrenocortical dysplasia protein homolog protein, from Human, contains 458 amino acids, locates in Nucleus.

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, Promotes binding of POT1 to single-stranded telomeric DNA, Modulates the inhibitory effects of POT1 on telomere elongation, The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity, May play a role in organogenesis


This is Pre-B-cell leukemia transcription factor-interacting protein 1 protein, from Human, contains 731 amino acids, locates in Cytoplasm.

Regulator of pre-B-cell leukemia transcription factors (BPXs) function, Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1, Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling


This is Mitochondrial calcium uniporter regulator 1 protein, from Human, contains 359 amino acids, is membrane-bound, locates in Mitochondrion.

Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564), Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883), Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846)


This is Transcription factor E2F7 protein, from Human, contains 911 amino acids, locates in Nucleus.

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response, Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3', Directly represses transcription of classical E2F transcription factors such as E2F1, Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes, Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3), Required for placental development by promoting polyploidization of trophoblast giant cells, Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication, Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene, Acts as a negative regulator of keratinocyte differentiation


This is EEF1A lysine methyltransferase 3 protein, from Human, contains 226 amino acids, is soluble, locates in Cytoplasm.

Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner, EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation

Belongs to the methyltransferase superfamily, METTL21 family


This is Mitochondrial import receptor subunit TOM6 homolog protein, from Human, contains 74 amino acids, is membrane-bound, locates in Mitochondrion.


This is Transmembrane and immunoglobulin domain-containing protein 2 protein, from Human, contains 282 amino acids, has 1 Ig-like Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Plays a role in cell-cell interaction, cell migration, and angiogenesis, Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation, Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade


This is Ubiquitin thioesterase otulin protein, from Human, contains 352 amino acids, is soluble, locates in Cytoplasm.

Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:26997266, PubMed:23708998, PubMed:23746843, PubMed:23806334, PubMed:23827681, PubMed:27523608, PubMed:27559085, PubMed:24726323, PubMed:24726327, PubMed:28919039, PubMed:35170849, PubMed:35587511), Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998), Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (PubMed:23746843, PubMed:23806334), OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:26670046), Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608), In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608), Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (PubMed:23806334)

Belongs to the peptidase C65 family, Otulin subfamily


This is Cytochrome c oxidase assembly factor 7 protein, from Human, contains 231 amino acids, is soluble, locates in Mitochondrion.

Required for assembly of mitochondrial respiratory chain complex I and complex IV

Belongs to the hcp beta-lactamase family


This is Armadillo repeat-containing protein 5 protein, from Human, contains 935 amino acids, is soluble, locates in Cytoplasm.

Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity), Negatively regulates adrenal cells survival, Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429)


This is 5-methylcytosine rRNA methyltransferase NSUN4 protein, from Human, contains 384 amino acids, locates in Mitochondrion.

Involved in mitochondrial ribosome assembly, 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU), Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled, In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4

Belongs to the class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family


This is HAUS augmin-like complex subunit 1 protein, from Human, contains 278 amino acids, is soluble, locates in Cytoplasm.

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex


This is FAD-dependent oxidoreductase domain-containing protein 1 protein, from Human, contains 486 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554), Involved in mid-late stages of complex I assembly (PubMed:25678554)


This is Netrin-G2 protein, from Human, contains 530 amino acids, is membrane-bound, locates in Cell membrane.

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels, Promotes neurite outgrowth of both axons and dendrites


This is 60S ribosomal export protein NMD3 protein, from Human, contains 503 amino acids, locates in Cytoplasm.

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit


This is EP300-interacting inhibitor of differentiation 2B protein, from Human, contains 161 amino acids, locates in Nucleus.

Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation


This is Regulator of microtubule dynamics protein 1 protein, from Human, contains 314 amino acids, is soluble, locates in Cytoplasm.


This is Carboxymethylenebutenolidase homolog protein, from Human, contains 245 amino acids, is soluble, locates in Cytoplasm.

Cysteine hydrolase, Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine, May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin

Belongs to the dienelactone hydrolase family


This is Endoplasmic reticulum resident protein 27 protein, from Human, contains 273 amino acids, is soluble, locates in Endoplasmic reticulum.

Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates (PubMed:16940051, PubMed:23192347), Binds protein substrates via a hydrophobic pocket in the C-terminal domain (PubMed:16940051, PubMed:23192347), May play a role in the unfolded stress response (PubMed:23192347)

Belongs to the protein disulfide isomerase family


This is Inositol-trisphosphate 3-kinase C protein, from Human, contains 683 amino acids, locates in Cytoplasm.

Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803), Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity)

Belongs to the inositol phosphokinase (IPK) family


This is Ankyrin repeat and SOCS box protein 9 protein, from Human, contains 294 amino acids, locates in Mitochondrion.

Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Recognizes at least two forms of creatine kinase, CKB and CKMT1A

Belongs to the ankyrin SOCS box (ASB) family


This is RecQ-mediated genome instability protein 2 protein, from Human, contains 147 amino acids, locates in Nucleus.

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates, It is required to regulate sister chromatid segregation and to limit DNA crossover, Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM, In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM


This is Dehydrodolichyl diphosphate synthase complex subunit NUS1 protein, from Human, contains 293 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery, Both subunits contribute to enzymatic activity, i,e, condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466), Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466), Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol, Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300)


This is Killer cell lectin-like receptor subfamily G member 1 protein, from Human, contains 195 amino acids, is membrane-bound, locates in Cell membrane.

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands, May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells