This is Mitochondrial import inner membrane translocase subunit TIM18 protein, from Baker's yeast, contains 192 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force, Its role in the complex is unclear but it may be involved in the assembly and stabilization of the TIM22 complex


This is Bud site selection protein 7 protein, from Baker's yeast, contains 746 amino acids, is membrane-bound, locates in Golgi apparatus.

Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3, May be involved in positioning the proximal bud pole signal


This is RNA-binding protein VTS1 protein, from Baker's yeast, contains 523 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein involved in post-transcriptional regulation through transcript degradation of SRE (SMG-recognition elements) bearing mRNAs


This is Syntaxin-5 protein, from Rat, contains 355 amino acids, is membrane-bound, locates in Golgi apparatus.

Mediates endoplasmic reticulum to Golgi transport (PubMed:10930451, PubMed:14742712, PubMed:9506515), Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus (PubMed:18167358)


This is Microphthalmia-associated transcription factor protein, from Mouse, contains 526 amino acids, locates in Nucleus.

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival, Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) (PubMed:23207919), Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1), Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium


This is Guanine nucleotide-binding protein subunit beta 1 protein, from Baker's yeast, contains 897 amino acids, is soluble, locates in Cytoplasm.

Beta subunit of a guanine nucleotide-binding protein (G proteins), G proteins are involved as modulators or transducers in various transmembrane signaling systems, The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction, Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase, Required for the control of pseudohyphal and haploid invasive growth


This is Ferric reductase transmembrane component 3 protein, from Baker's yeast, contains 711 amino acids, is membrane-bound, locates in Cell membrane.

Siderophore-iron reductase responsible for reducing extracellular iron prior to import, Catalyzes the reductive uptake of Fe(3+) bound to di- and trihydroxamate siderophores, Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane

Belongs to the ferric reductase (FRE) family


This is Histone deacetylase complex subunit CTI6 protein, from Baker's yeast, contains 506 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of the RPD3C(L) histone deacetylase complex (HDAC), Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, CTI6 links the SAGA coactivator to the CYC8-TUP1 corepressor, Involved in transcription regulation of heme-regulated genes and required for GCN5 recruitment, histone H3 acetylation and SPT15/TBP binding to promoters


This is FACT complex subunit SSRP1 protein, from Human, contains 709 amino acids, locates in Nucleus.

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes, The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair, During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure, It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II, The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II), Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin, May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA, Also acts as a transcriptional coactivator for p63/TP63


This is Phosphatidylglycerol phospholipase C protein, from Baker's yeast, contains 321 amino acids, is membrane-bound, locates in Mitochondrion.

Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C-type degradation mechanism

Belongs to the glycerophosphoryl diester phosphodiesterase family


This is Flavin carrier protein 1 protein, from Baker's yeast, contains 793 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding

Belongs to the transient receptor potential (TRP) ion channel family


This is S-adenosylmethionine permease SAM3 protein, from Baker's yeast, contains 587 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source

Belongs to the amino acid-polyamine-organocation (APC) superfamily, YAT (TC 2,A,3,10) family


This is Probable glutathione-independent glyoxalase HSP32 protein, from Baker's yeast, contains 237 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step, May play a role in detoxifying endogenously produced glyoxals, Involved in protection against reactive oxygen species (ROS) (By similarity), Important for viability in stationary phase, May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893)

Belongs to the peptidase C56 family, HSP31-like subfamily


This is Mitotic-spindle organizing protein 1 protein, from Human, contains 82 amino acids, is soluble, locates in Cytoplasm.

Required for gamma-tubulin complex recruitment to the centrosome


This is Multicilin protein, from African clawed frog, contains 374 amino acids, locates in Nucleus.

Transcription regulator specifically required for multiciliate cell differentiation, Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis, Activates genes required for centriole assembly (plk4, cep152) and genes specifically required for motile cilia formation (foxj1), Also promotes the deuterosome pathway of centriole biogenesis by activating expression of ccdc67/deup1, but not its paralog cep63


This is Sialic acid-binding Ig-like lectin 14 protein, from Human, contains 396 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Putative adhesion molecule, Sialic acid-binding paired receptor which may activate associated receptors

Belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family


This is 3'-5' exonuclease eri1 protein, from Fission yeast, contains 313 amino acids, is soluble, locates in Cytoplasm.

RNA exonuclease that acts as a negative regulator of RNA interference (RNAi), Acts by degrading the 3'-overhangs of double-stranded short interfering RNAs (siRNAs), Represses the accumulation of heterochromatic siRNAs leading to negative regulation of the RNAi-mediated heterochromoatin assembly, Also involved in rRNA biogenesis, trimming the 5,8S ribosomal RNA (rRNA) from a slightly longer pre-5,8S RNA in the cytoplasm


This is Locomotion-related protein Hikaru genki protein, from Fruit fly, contains 958 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C2-type

Plays a role in the formation of functional neural circuits from the early stages of synapse formation, Has a role in the development of CNS functions involved in locomotor activity


This is Purple acid phosphatase protein, from Soybean, contains 464 amino acids, is soluble, locates in Extracellular.

Belongs to the metallophosphoesterase superfamily, Purple acid phosphatase family


This is High affinity cationic amino acid transporter 1 protein, from Mouse, contains 622 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Acts as a receptor for the ecotropic murine retroviral leukemia virus

Belongs to the amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2,A,3,3) family


This is Fem-3 mRNA-binding factor 2 protein, from Caenorhabditis elegans, contains 632 amino acids, is soluble, locates in Cytoplasm.

Involved in the control of stem cells and sex determination in the C,elegans hermaphrodite germline (PubMed:9393998), May also play a role in the hermaphrodite germline proliferation and oogenesis (PubMed:15454534, PubMed:27864381), By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone (PubMed:16319922), Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch (PubMed:9393998), Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR (PubMed:15454534), Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes (PubMed:22820175)


This is Sentrin-specific protease protein, from Caenorhabditis elegans, contains 697 amino acids, locates in Nucleus.

Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form


This is Serine/threonine-protein kinase/endoribonuclease ire-1 protein, from Caenorhabditis elegans, contains 967 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:11779465), The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes (PubMed:11779465), Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis (PubMed:11779465, PubMed:16184190), Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 and many other genes, upon ER stress (PubMed:18216284, PubMed:16184190), By activating the UPR pathway during non-lethal hypoxia pre-conditioning, confers adaptive protection to subsequent exposure to hypoxia (PubMed:20733002), ire-1 and pek-1 are redundant genes that control a pathway essential for larval development and survival (PubMed:11779465, PubMed:16184190), Plays a role in the nuclear retention of unspliced mRNAs (PubMed:23149939)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Myosin regulatory light chain protein, from Caenorhabditis elegans, contains 172 amino acids, is soluble, locates in Cytoplasm.

Regulates myosin II activity and organization during embryo elongation, May be involved in the organization of mlc-5 into bundles (PubMed:19675126), Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity (PubMed:10427096)


This is Homeobox protein vab-15 protein, from Caenorhabditis elegans, contains 225 amino acids, locates in Nucleus.

Probable transcription factor needed for the proper production of touch cell precursors (PubMed:11333230), Involved in specification of lateral neuroblasts (PubMed:28716930), Essential for embryonic morphogenesis (PubMed:11333230)


This is DNA repair protein rad32 protein, from Fission yeast, contains 649 amino acids, locates in Nucleus.

Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation, May work in conjunction with rhp51


This is Rho-GTPase-activating protein 8 protein, from Fission yeast, contains 777 amino acids, is soluble, locates in Cytoplasm.

Acts in signal transduction, Negatively regulates the pak1/shk1 control pathway


This is Lanosterol 14-alpha demethylase erg11 protein, from Fission yeast, contains 495 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions (PubMed:27585850, PubMed:28893786) (Probable), The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity), In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity), Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol (Probable), Can also use susbtrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity)


This is Serine/threonine-protein kinase ppk5 protein, from Fission yeast, contains 836 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily


This is GTP-binding protein rho1 protein, from Fission yeast, contains 202 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the regulation of cell wall growth and actin cytoskeleton organization, Activates (1,3)-beta-D-glucan synthase

Belongs to the small GTPase superfamily, Rho family


This is Phosphoprotein p93 protein, from Fission yeast, contains 882 amino acids, is soluble, locates in Cytoplasm.

Has a role in sister chromatid separation


This is NIP3 homolog protein, from Caenorhabditis elegans, contains 221 amino acids, is membrane-bound, locates in Mitochondrion.

Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes (PubMed:11114722), Has a role in lifespan and tumor growth (PubMed:16380712, PubMed:17934462), Required for the induction of mitophagy under stress conditions (PubMed:25896323)


This is Leucine-rich repeat-containing protein ODA7 protein, from Chlamydomonas smithii, contains 432 amino acids, is soluble, locates in Cytoplasm.

Cilium-specific protein required for cilia structures, Axonemal dynein-associated protein that participates in a structural link between inner and outer row dyneins


This is Guanine nucleotide-binding protein alpha-1 subunit protein, from Rice, contains 380 amino acids, is membrane-bound, locates in Cell membrane.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable), May function in a signal transduction pathway required for normal growth and development of internodes, leaves, panicles and seeds (PubMed:10377457), Involved in gibberellin signal transduction (PubMed:10468600, PubMed:11027362), Involved in R gene-mediated disease resistance, Functions upstream of the small GTPase RAC1 in the early steps of signaling (PubMed:12237405), Involved in brassinosteroid (BR) response, May not be a signaling molecule in BRI1-mediated perception or transduction (PubMed:17117160, PubMed:19036785), Acts together with the E3 ubiquitin ligase TUD1 to mediate a BR signaling pathway that affects plant growth and development (PubMed:23526892)


This is Sperm flagellar protein 1 protein, from African clawed frog, contains 229 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation, Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (PubMed:25070955), Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity), Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities (By similarity), Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (PubMed:29514918)


This is DEAD-box ATP-dependent RNA helicase 56 protein, from Rice, contains 432 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in pre-mRNA splicing, Required for the export of mRNA out of the nucleus (By similarity), Required for tapetal programmed cell death (PCD) and degeneration during anther development, Forms dimer with AIP2 and binds the promoter region of the cysteine protease CP1, Can complement the yeast RNA helicase SUB2, Plants silencing AIP1 and AIP2 are male sterile (PubMed:21467577)

Belongs to the DEAD box helicase family, DECD subfamily


This is 4-hydroxy-2-oxoglutarate aldolase, mitochondrial protein, from Bovine, contains 327 amino acids, locates in Mitochondrion.

Catalyzes the final step in the metabolic pathway of hydroxyproline


This is Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial protein, from Pig, contains 664 amino acids, is membrane-bound, locates in Mitochondrion.

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable), Can act as a tumor suppressor (By similarity)

Belongs to the FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily


This is Hypoxia-inducible factor 3-alpha protein, from Mouse, contains 662 amino acids, locates in Cytoplasm.

Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:18070924), Also plays a role in the development of the lung and heart during embryonic and neonatal stages (PubMed:18070924)


This is Protein INCA1 protein, from Human, contains 236 amino acids, locates in Nucleus.

Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187), Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity), Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity)


This is Fanconi anemia core complex-associated protein 100 protein, from Human, contains 881 amino acids, locates in Nucleus.

Plays a role in Fanconi anemia-associated DNA damage response network, Regulates FANCD2 monoubiquitination and the stability of the FA core complex, Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed


This is Ragulator complex protein LAMTOR4 protein, from Human, contains 99 amino acids, locates in Lysosome/Vacuole.

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids, Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag, Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated


This is ABC transporter B family member 27 protein, from Mouse-ear cress, contains 644 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Probably involved in redistribution of internalized aluminum, May mediate vacuolar sequestration of a metal complex

Belongs to the ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3,A,1,201) subfamily


This is 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 3, chloroplastic protein, from Mouse-ear cress, contains 812 amino acids, locates in Plastid.

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation

Belongs to the vitamin-B12 independent methionine synthase family


This is Ethylene receptor 2 protein, from Mouse-ear cress, contains 773 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Ethylene receptor related to bacterial two-component regulators, Acts as a redundant negative regulator of ethylene signaling


This is mRNA export factor GLE1 protein, from Mouse-ear cress, contains 611 amino acids, locates in Nucleus.


This is Peptidyl-prolyl cis-trans isomerase FKBP20-2, chloroplastic protein, from Mouse-ear cress, contains 242 amino acids, locates in Plastid.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity), Involved in the accumulation of the PSII complex


This is Protein RRP6-like 1 protein, from Mouse-ear cress, contains 637 amino acids, is soluble, locates in Nucleus.

Acts as an important epigenetic regulator through multiple silencing mechanisms (PubMed:23555312, PubMed:24726328, PubMed:24719467, PubMed:25211139), Involved in transcriptional gene silencing (TGS), Plays a role for DNA methylation in the RNA-directed DNA methylation (RdDM) pathway, Contributes to the methylation status of the retrotransposon SN1, Required for DNA methylation only at a subset of RdDM target loci (PubMed:24719467), Plays a regulatory role in RdDM through retention of non-coding RNAs (ncRNAs) in normal cells, Helps to retain Pol V-transcribed RNAs in chromatin to enable their scaffold function and is required for genome-wide Pol IV-dependent siRNA (24 nt siRNA) production that may involve retention of Pol IV transcripts (PubMed:24726328), Involved in association with RRP6L2 in the silencing of the solo LTR locus, Controls levels of ncRNAs from the solo LTR locus, Seems to function independently of the RdDM pathway (PubMed:23555312), Functions redundantly with RRP6L2 in the regulation of FLC locus, Participates in the maintenance of trimethylated 'Lys-27' (H3K27me3) at FLC locus via the regulation of antisense long non-coding RNAs (lncRNAs) and the regulation of diverse antisense RNAs derived from the FLC locus (PubMed:25211139), Seems not involved in the exosomal RNA degradation (PubMed:24726328, PubMed:25211139), Can complement the growth defect of a yeast mutant lacking RRP6 exonuclease (PubMed:18285452)


This is Microtubule integrity protein mal3 protein, from Fission yeast, contains 308 amino acids, is soluble, locates in Cytoplasm.

May play a role in regulating the integrity of microtubules possibly by influencing their stability, Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends, Strongly stimulates the ATPase activity of tea2


This is GTP-binding protein rho2 protein, from Fission yeast, contains 200 amino acids, is membrane-bound, locates in Cell membrane.

Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity, Regulates the synthesis of alpha-D-glucan through activation of pck2


This is Nucleoporin nsp1 protein, from Fission yeast, contains 598 amino acids, is membrane-bound, locates in Nucleus.

Functions as a component of the nuclear pore complex (NPC), NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors, Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope

Belongs to the nucleoporin NSP1/NUP62 family


This is Putative glycine--tRNA ligase protein, from Fission yeast, contains 652 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP), Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs, Thereby, may play a special role in Ap4A homeostasis

Belongs to the class-II aminoacyl-tRNA synthetase family


This is Septation protein imp2 protein, from Fission yeast, contains 670 amino acids, is soluble, locates in Cytoplasm.

Required for normal septation, Involved in the disassembly of the medial ring during septation


This is Telobox protein 1 protein, from Fission yeast, contains 390 amino acids, locates in Nucleus.

General transcription factor with prominent roles in controlling histone levels and stability, Binds and regulates the activities of many promoters, including those controlling the expression of all four types of canonical histones, Is also involved in the centromeric loading of cnp1 and maintenance of centromere identity, Moreover, regulates the expression of cdc2, a protease capable of histone clipping


This is Poly(A) polymerase pla1 protein, from Fission yeast, contains 566 amino acids, locates in Nucleus.

Polymerase that creates the 3'-poly(A) tail of mRNA's, May acquire specificity through interaction with a cleavage and polyadenylation factor (CF I)

Belongs to the poly(A) polymerase family


This is Probable E3 ubiquitin-protein ligase dma1 protein, from Fission yeast, contains 267 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised, Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation, The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB


This is Serine O-succinyltransferase protein, from Fission yeast, contains 504 amino acids, locates in Mitochondrion.

Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine, Has also weak serine acetyl transferase activity and homoserine succinyl transferase activity

Belongs to the AB hydrolase superfamily, MetX family


This is Cruciform cutting endonuclease 1, mitochondrial protein, from Fission yeast, contains 258 amino acids, locates in Mitochondrion.

Capable of resolving Holliday junctions, Specific for 4-way junctions, Seems to be important for the maintenance of mitochondrial DNA, Cleaves fixed junctions at the point of strand exchange, Cleaves after 5'-CT-3' and 5'-TT-3' sequences


This is F-actin-capping protein subunit alpha protein, from Fission yeast, contains 256 amino acids, is soluble, locates in Cytoplasm.

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends, Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments, Competes with formin cdc12 for attachment to the actin filaments barbed ends, Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction

Belongs to the F-actin-capping protein alpha subunit family


This is Nuclease 1, mitochondrial protein, from Fission yeast, contains 322 amino acids, is membrane-bound, locates in Mitochondrion.

This enzyme has both RNase and DNase activity, It degrades single-stranded DNA and RNA

Belongs to the DNA/RNA non-specific endonuclease family


This is Protein lin-32 protein, from Caenorhabditis elegans, contains 142 amino acids, locates in Nucleus.

Probable transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3' (PubMed:11076762), Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs (PubMed:7800042), Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis (PubMed:31386623), Required for specification of cell fate, acting in concert with lin-32, in the development of the male-specific genital sensilla (simple sense organs) known as rays (PubMed:11076762), Involved in regulating glial specification, perhaps by suppressing a glial fate in different lineages during early embryogenesis (PubMed:32665354)


This is Transcription factor elt-2 protein, from Caenorhabditis elegans, contains 433 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' (PubMed:7782329, PubMed:15733671, PubMed:18003741, PubMed:18024960, PubMed:18448117, PubMed:26700680, PubMed:26016853, PubMed:26963674), Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1, vit-2 and lev-11, and itself (PubMed:9659934, PubMed:10518545, PubMed:15733671, PubMed:18448117, PubMed:19111532, PubMed:26700680, PubMed:26963674), Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine (PubMed:20807527), Regulates intestinal gene expression in response to hypoxia to promote longevity (PubMed:25284791), Modulation of longevity may, in part, be the result of regulation of expression of daf-16 isoforms d and f in the intestine (PubMed:24834345), Regulates tissue specific gene expression at basal levels and in response to bacterial infection in the intestine to control innate immunity (PubMed:16968778, PubMed:21168435, PubMed:25340560, PubMed:26016853), Plays a role in the induction of metal-responsive genes, activating gene expression from zinc-activated promoters and iron-dependent promoters and enhancers (PubMed:18024960, PubMed:22194696, PubMed:25552416), May regulate the expression of genes that control sensitivity to oxidative stress, in a mab-3-dependent manner, and osmotic stress, in conjunction with the GATA region-binding transcription factor elt-3 (PubMed:17901115, PubMed:20498281, PubMed:20126308), May play a role in sphingolipid signaling by regulating the expression of the sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735), May act with the Notch signaling pathway to promote endodermal gene expression (PubMed:18003741), Has a protective role in response to infection by Gram-negative bacteria such as S,enterica, E,coli, P,aeruginosa and B,pseudomallei, Gram-positive bacterium E,faecalis and fungal pathogen C,neoformans (PubMed:16968778, PubMed:17183709, PubMed:21168435, PubMed:23980181, PubMed:30265660), An association with the 26S proteasome regulatory subunit rpt-6, in part, controls gene expression in response to infection by P,aeruginosa (PubMed:30265660), Regulates gene expression during the recovery phase following a bacterial infection (PubMed:25340560, PubMed:30265660), May act with p38-activated transcription factors to control p38 gene induction in response to bacterial infection (PubMed:22967128, PubMed:26016853), Controls lysosome formation in the intestine by controlling lysosomal gene expression (PubMed:26828939)


This is Snake venom metalloproteinase-disintegrin-like mocarhagin protein, from Mozambique spitting cobra, contains 609 amino acids, is soluble, locates in Extracellular.

Snake venom zinc metalloproteinase that inhibits platelet aggregation by cleaving platelet glycoprotein Ib alpha (GP1BA) at Glu-298/Asp-299, and abolishes binding of von Willebrand factor (VWF) to GPIBA, Cleaves P-selectin glycoprotein ligand-1 (PSGL-1/SELPLG) at Tyr-51/Asp-52, and completely abolishes the binding of PSGL-1 to P-selectin, Anionic amino acid sequences containing sulfated tyrosines are needed for cleavages, Inhibits the thrombin-induced platelet aggregation, and the thrombin-induced release of ATP and ADP, Has lectin activity (inhibited by heparin)

Belongs to the venom metalloproteinase (M12B) family, P-III subfamily, P-IIIa sub-subfamily


This is Cell division cycle protein cdt2 protein, from Fission yeast, contains 490 amino acids, locates in Nucleus.

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for DNA replication during mitosis and meiosis, The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of cdt1 and spd1, Involved in the regulation of mitotic and pre-meiotic S-phase progression


This is Glycolate oxidase 1 protein, from Rice, contains 369 amino acids, locates in Peroxisome.

Catalyzes the oxidation of glycolate to glyoxylate, with a reduction of O2 to H2O2 (PubMed:16595582), Is a key enzyme in photorespiration in plants (By similarity), To a lesser extent, is also able to oxidize glyoxylate to oxalate in vitro (PubMed:16595582), Can exert a strong regulation over photosynthesis, possibly through a feed-back inhibition on Rubisco activase (PubMed:19264754), Does not seem to play a role in oxalate accumulation (PubMed:16595582)

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family


This is L-ascorbate peroxidase 1, cytosolic protein, from Rice, contains 250 amino acids, is soluble, locates in Cytoplasm.

Plays a key role in hydrogen peroxide removal

Belongs to the peroxidase family, Ascorbate peroxidase subfamily


This is Inositol-tetrakisphosphate 1-kinase 2 protein, from Rice, contains 349 amino acids, locates in Endoplasmic reticulum.

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds, Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds (By similarity), May be involved in the negative regulation of osmotic stress signaling (PubMed:18421420, PubMed:22038091)


This is Calpain-A protein, from Fruit fly, contains 828 amino acids, is soluble, locates in Cytoplasm.

Calcium-regulated non-lysosomal thiol-protease, Involved in the organization of the actin-related cytoskeleton during embryogenesis


This is Protein let-756 protein, from Caenorhabditis elegans, contains 425 amino acids, is membrane-bound, locates in Nucleus.

Required for larval development (PubMed:9331368), Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development (PubMed:16495308)

Belongs to the heparin-binding growth factors family


This is Serine/threonine-protein kinase ENV7 protein, from Baker's yeast, contains 364 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Serine/threonine-protein kinase involved in vacuolar processing and morphology

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Palmitoyltransferase PFA4 protein, from Baker's yeast, contains 378 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function, Palmitoylates several amino acid permeases (PubMed:16751107), Palmitoylates chitin synthase CHS3, which is required for its proper export from the ER (PubMed:16818716, PubMed:28346351), Can palmitoylate RAS2 in vitro (PubMed:12379641)

Belongs to the DHHC palmitoyltransferase family, PFA4 subfamily


This is tRNA (guanine-N(7)-)-methyltransferase protein, from Baker's yeast, contains 286 amino acids, locates in Nucleus.

Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay, Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity

Belongs to the class I-like SAM-binding methyltransferase superfamily, TrmB family


This is Phosducin-like protein 2 protein, from Baker's yeast, contains 286 amino acids, is soluble, locates in Cytoplasm.

Essential for cell growth (PubMed:10749875), Inhibits early G-protein signaling events following pheromone stimulation (PubMed:10749875), Inhibits the folding activity of the chaperonin-containing T-complex (CCT) CCT2 which leads to inhibition of cytoskeletal actin folding (PubMed:17429077), Plays a role in cell cycle progression in G1/S phase (PubMed:17429077)


This is Ribosome biogenesis protein YTM1 protein, from Baker's yeast, contains 460 amino acids, is soluble, locates in Nucleus.

Component of the NOP7 complex, which is required for maturation of the 25S and 5,8S ribosomal RNAs and formation of the 60S ribosome

Belongs to the WD repeat WDR12/YTM1 family


This is Ribosome biogenesis protein NOP53 protein, from Baker's yeast, contains 455 amino acids, is soluble, locates in Nucleus.

Late-acting factor in the nuclear maturation of 60S ribosomal subunits, which is required for normal acquisition of export competence, Required for the export of the large subunit, Acts to stimulate the RNase activity of the exosome complex, and may recruit the exosome to 7S pre-rRNA for processing, Associates with numerous RNAs including the 27S and 7S pre-rRNAs and the box H/ACA snoRNA snR37, Also interacts (via N-terminal region) with the mature 25S rRNA and the mature 5,8S rRNA


This is Mitochondrial tRNA-specific 2-thiouridylase 1 protein, from Baker's yeast, contains 417 amino acids, locates in Mitochondrion.

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln), Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position, ATP is required to activate the C2 atom of the wobble base


This is ATP-dependent RNA helicase FAL1 protein, from Baker's yeast, contains 399 amino acids, locates in Nucleus.

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis, Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA

Belongs to the DEAD box helicase family, DDX48/FAL1 subfamily


This is Mitochondrial adapter protein MCP1 protein, from Baker's yeast, contains 302 amino acids, is membrane-bound, locates in Mitochondrion.

Recruits the lipid transfer protein Vps13 to mitochondria thereby promoting vacuole-mitochondria contacts (PubMed:28864540, PubMed:30018089, PubMed:34830155), Involved in mitochondrial lipid homeostasis (PubMed:23781023, PubMed:28864540)


This is Chitin biosynthesis protein CHS5 protein, from Baker's yeast, contains 671 amino acids, is membrane-bound, locates in Golgi apparatus.

Component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3, Also involved in targeting FUS1 to sites of polarized growth


This is Mediator of RNA polymerase II transcription subunit 2 protein, from Baker's yeast, contains 431 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the mediator complex subunit 2 family


This is Something about silencing protein 10 protein, from Baker's yeast, contains 610 amino acids, locates in Nucleus.

Primarily required at the G2/M phase, Essential for viability: involved in nucleolar processing of pre-18S ribosomal RNA as part of the ribosomal small subunit (SSU) processome


This is Exosome complex exonuclease RRP6 protein, from Baker's yeast, contains 733 amino acids, locates in Nucleus.

Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events, In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm, The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes, RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site

Belongs to the exosome component 10/RRP6 family


This is Sterol uptake control protein 2 protein, from Baker's yeast, contains 913 amino acids, locates in Nucleus.

Transcription factor that is involved in activation of anaerobic genes such as DAN/TIR cell wall mannoprotein genes and YML083c, Appears to bind to anaerobic response elements (AR1) with the consensus sequence 5'-TCGTTYAG-3' present in the promoter regions of DAN/TIR genes, Involved in sterol uptake and regulation of the sterol biosynthesis, Binds to sterol regulatory elements (SRE) with the consensus sequence 5'-TCGTATA-3' present in ERG2 and ERG3 promoters, May be involved in down-regulation of CWP2 during anaerobic adaptation


This is Sister chromatid cohesion protein 1 protein, from Baker's yeast, contains 566 amino acids, locates in Nucleus.

Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle, The cohesin complex is required for the cohesion of sister chromatids after DNA replication, The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped, At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate


This is 2-isopropylmalate synthase 2, mitochondrial protein, from Baker's yeast, contains 604 amino acids, locates in Mitochondrion.

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate), Redundant to LEU4, responsible for about 20% of alpha-IPMS activity, Involved in leucine synthesis

Belongs to the alpha-IPM synthase/homocitrate synthase family, LeuA type 2 subfamily


This is Transposon Ty3-G Gag polyprotein protein, from Baker's yeast, contains 290 amino acids, has 1 CCHC-type Zinc finger, is soluble, locates in Cytoplasm.

CCHC-type

Nucleocapsid protein p9 (NC) forms the nucleocore that coats the retro-elements dimeric RNA, Binds these RNAs through its zinc fingers (By similarity), Promotes primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty3 RNA and initiation of reverse transcription


This is Adrenodoxin homolog, mitochondrial protein, from Baker's yeast, contains 172 amino acids, is soluble, locates in Mitochondrion.

Required for Fe-S cluster incorporation into mitochondrial and cytosolic apoproteins, May be part of a novel electron transport chain

Belongs to the adrenodoxin/putidaredoxin family


This is Branchpoint-bridging protein protein, from Baker's yeast, contains 476 amino acids, has 2 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

CCHC-type

Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing, 2 commitment complexes, CC1 and CC2, have been defined, CC1 is a basal complex dependent only on the 5'-splice site, CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5'-splice site region, This protein is involved in CC2 formation where it binds to the snRNP U1-associated protein PRP40, bridging the U1 snRNP-associated 5'-splice site and the MSL5-associated branch point 3' intron splice site, Involved in nuclear retention of pre-mRNA


This is Serine/threonine-protein kinase RIO1 protein, from Baker's yeast, contains 484 amino acids, is soluble, locates in Cytoplasm.

Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA, Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit, The association with the very late 40S subunit intermediate seems to follow RIO2 association with precursors of the 40S subunit and may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit, Despite the protein kinase domain is proposed to act predominantly as an ATPase, The catalytic activity regulates its dynamic association with the 40S subunit, Has a role in the cell cycle where it is required for entrance into S-phase and in the control of the onset of anaphase, Appears to also be involved in the maintenance of chromosome stability and correct mitotic segregation

Belongs to the protein kinase superfamily, RIO-type Ser/Thr kinase family


This is Non-classical export protein 2 protein, from Baker's yeast, contains 173 amino acids, is membrane-bound, locates in Cell membrane.

Involved in membrane organization, Required for the formation of membrane compartments of CAN1 (MCCs), localization of CAN1 at the MCCs and subsequent invagination of the plasma membrane at the MCCs sites, Involved in eisosome organization and might act as a sensor of sphingolipids that regulates plasma membrane function, Involved in a novel pathway of export of proteins that lack a cleavable signal sequence, It may be an accessory subunit to an essential core component of the non-classical export machinery, Non-classical export pathway functions also as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient


This is tRNA pseudouridine synthase 1 protein, from Baker's yeast, contains 544 amino acids, locates in Nucleus.

Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr) (PubMed:9671058, PubMed:10356324, PubMed:25219674), Catalyzes pseudouridylation at position 44 in U2 snRNA (PubMed:25219674), Also catalyzes pseudouridylation of mRNAs (PubMed:25219674, PubMed:31477916)

Belongs to the tRNA pseudouridine synthase TruA family


This is Large ribosomal subunit protein uL30B protein, from Baker's yeast, contains 244 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the universal ribosomal protein uL30 family


This is E3 SUMO-protein ligase SIZ2 protein, from Baker's yeast, contains 726 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

May act as an E3 ligase mediating SUMO/Smt3 attachment to septins, May be involved in chromosome maintenance


This is U3 small nucleolar RNA-associated protein 12 protein, from Baker's yeast, contains 943 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA

Belongs to the WD repeat WDR3/UTP12 family


This is UBX domain-containing protein 3 protein, from Baker's yeast, contains 455 amino acids, is soluble, locates in Cytoplasm.

Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:25078903, PubMed:29355480), Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway, Involved in delivery of substrates to the 26S proteasome, Also required for membrane fusion (By similarity)


This is Sphingolipid long chain base-responsive protein LSP1 protein, from Baker's yeast, contains 341 amino acids, is soluble, locates in Cytoplasm.

Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis, Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway, Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress


This is Vacuolar v-SNARE NYV1 protein, from Baker's yeast, contains 253 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Vacuolar v-SNARE required for docking, Only involved in homotypic vacuole fusion, Required for Ca(2+) efflux from the vacuolar lumen, a required signal for subsequent membrane fusion events, by inhibiting vacuolar Ca(2+)-ATPase PMC1 and promoting Ca(2+) release when forming trans-SNARE assemblies during the docking step


This is Polyamine transporter 4 protein, from Baker's yeast, contains 659 amino acids, is membrane-bound, locates in Cell membrane.

Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm, Recognizes spermidine, spermine and the antimalarial drug quinidine, but not quinine, chloroquine and mefloquine

Belongs to the major facilitator superfamily, DHA1 family, Polyamines/proton antiporter (TC 2,A,1,2,16) subfamily


This is Ribose-phosphate pyrophosphokinase 5 protein, from Baker's yeast, contains 496 amino acids, is soluble, locates in Cytoplasm.

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis, Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Belongs to the ribose-phosphate pyrophosphokinase family


This is FAD-linked sulfhydryl oxidase ERV2 protein, from Baker's yeast, contains 196 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation in the endoplasmic reticulum lumen in parallel to ERO1


This is Cytochrome c oxidase copper chaperone protein, from Baker's yeast, contains 69 amino acids, is soluble, locates in Mitochondrion.

Copper chaperone for cytochrome c oxidase (COX), Binds two copper ions and deliver them to the Cu(A) site of COX


This is Transcription initiation factor TFIID subunit 3 protein, from Baker's yeast, contains 353 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID, Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription


This is Aspartic proteinase yapsin-3 protein, from Baker's yeast, contains 508 amino acids, is membrane-bound, locates in Cell membrane.

Cleaves proteins C-terminally to mono- and paired-basic residues, Required for cell wall integrity


This is Thiosulfate:glutathione sulfurtransferase protein, from Baker's yeast, contains 139 amino acids, locates in Mitochondrion.

Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631), Provides the link between the first step in H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631), The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631)


This is Pre-mRNA-splicing factor CLF1 protein, from Baker's yeast, contains 687 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing and cell cycle progression, Required for the spliceosome assembly by promoting the functional integration of the U4/U6,U5 tri-snRNP particle into the U1-, U2-dependent pre-spliceosome, Also recruits PRP19 to the spliceosome, as a component of the NTC complex (or PRP19-associated complex), The association of the NTC complex to the spliceosome mediates conformational rearrangement or stabilizes the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation, Required for initiation of the DNA replication by binding the RNA replication origins, probably through its interaction with the origin recognition complex (ORC)


This is mRNA export factor GLE1 protein, from Baker's yeast, contains 538 amino acids, is membrane-bound, locates in Nucleus.

Functions as a component of the nuclear pore complex (NPC), NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors, It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC probably by binding the ATP-dependent RNA helicase DBP5 and GFD1 at the cytoplasmic side of the NPC, These interactions are thought to be important for the dissociation of transport proteins such as the heterogeneous nuclear ribonucleoprotein (hnRNP) NAB2 from exported mRNA


This is Mediator of RNA polymerase II transcription subunit 1 protein, from Baker's yeast, contains 566 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 1 family


This is Calcium channel YVC1 protein, from Baker's yeast, contains 675 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for release of calcium ions from the vacuole in response to hyperosmotic shock

Belongs to the transient receptor (TC 1,A,4) family


This is Mitochondrial import inner membrane translocase subunit TIM22 protein, from Baker's yeast, contains 207 amino acids, is membrane-bound, locates in Mitochondrion.

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins, such as mitochondrial carrier family members, into the mitochondrial inner membrane, In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel, Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps, Mediates the insertion of precursor proteins in a 3 step process, After the precursor is tethered to the translocase without losing energy from the Delta(psi), 2 energy-requiring steps are needed, First, Delta(psi) acts on the precursor protein and promotes its docking in the translocase complex, Then, Delta(psi) and an internal signal peptide together induce rapid gating transitions in one pore and closing of the other pore and drive membrane insertion to completion


This is Ferric/cupric reductase transmembrane component 7 protein, from Baker's yeast, contains 620 amino acids, is membrane-bound, locates in Cell membrane.

Cell surface metalloreductase, May be involved in copper homeostasis

Belongs to the ferric reductase (FRE) family


This is Protein SCM3 protein, from Baker's yeast, contains 223 amino acids, locates in Nucleus.

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres


This is Mediator of RNA polymerase II transcription subunit 4 protein, from Baker's yeast, contains 284 amino acids, locates in Nucleus.

Belongs to the Mediator complex subunit 4 family


This is Bifunctional protein RIB2 protein, from Baker's yeast, contains 591 amino acids, is soluble, locates in Cytoplasm.

Involved in riboflavin biosynthesis, Converts 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate

In the C-terminal section; belongs to the cytidine and deoxycytidylate deaminase family


This is Transcriptional modulator WTM1 protein, from Baker's yeast, contains 437 amino acids, locates in Cytoplasm.

Transcriptional modulator with roles in meiotic regulation and silencing, Acts either as an adapter to facilitate nuclear import by KAP122 of the RNR2-RNR4 herodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR); or as an anchor to retain RNR2-RNR4 in the nucleus


This is Spindle pole component BBP1 protein, from Baker's yeast, contains 385 amino acids, is soluble, locates in Cytoplasm.

Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication, Connects the central plaque of the SPB with the half-bridge, Required for proper localization of CDC5 at the SPB and for proper M-phase progression


This is Non-disjunction protein 1 protein, from Baker's yeast, contains 352 amino acids, locates in Nucleus.

Required for telomeric clustering (bouquet stage) during meiosis 1 prophase, formation and efficient homolog pairing, meiosis 1 disjunction, and telomere deletion during meiosis, Promotes also meiotic recombination


This is ATP-dependent RNA helicase DBP10 protein, from Baker's yeast, contains 995 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5,8S rRNAs

Belongs to the DEAD box helicase family, DDX54/DBP10 subfamily


This is Actin-related protein 7 protein, from Baker's yeast, contains 477 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is involved in transcriptional regulation, Heterodimer of ARP7 and ARP9 functions with HMG box proteins to facilitate proper chromatin architecture, Heterodimer formation is necessary for assembly into RSC complex, Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is G1-specific transcriptional repressor WHI5 protein, from Baker's yeast, contains 295 amino acids, locates in Cytoplasm.

Transcriptional repressor that negatively regulates G1-specific, SBF- and MBF-dependent transcription, Binds via SBF to promoters of G1-specific genes to repress transcription in early G1, During G1, phosphorylated by cyclin-CDK CLN3-CDC28 and progressively hyperphosphorylated by CDK associated with other G1-cyclins, which leads to dissociation of WHI5 from SBF, activating SBF-dependent transcription in late G1, Elimination of CDK activity at the end of mitosis by the mitotic exit network (MEN) allows WHI5 to reassociate with SBF to again repress G1/S transcription


This is Chromatin modification-related protein EAF3 protein, from Baker's yeast, contains 401 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair


This is Monothiol glutaredoxin-6 protein, from Baker's yeast, contains 231 amino acids, locates in Lysosome/Vacuole.

Belongs to the glutaredoxin family, Monothiol subfamily


This is Reticulon-like protein 2 protein, from Baker's yeast, contains 393 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Hsp90 co-chaperone AHA1 protein, from Baker's yeast, contains 350 amino acids, is soluble, locates in Cytoplasm.

Co-chaperone that binds to the molecular chaperone HSP82 and stimulates its ATPase activity, Binding to HSP82 promotes a conformational switch in the catalytic loop of HSP82, facilitating the interaction of the catalytic 'Arg-380' with ATP in the N-terminal nucleotide-binding domain, Although not essential, it confers thermotolerance when intracellular levels of HSP82 are limiting


This is RNA polymerase I termination factor protein, from Baker's yeast, contains 570 amino acids, locates in Nucleus.

DNA-binding protein that recognizes sequence-specific replication termini (Ter sites) within rDNA (PubMed:14576157), Binds to rDNA terminator elements and mediates efficient RNA polymerase I transcription termination (PubMed:22805593), Required for rDNA silencing at the non-transcribed spacer 1 (NTS1), Promotes the association of SIR2 with NTS1 and contributes to maintenance of rDNA stability (PubMed:22362748)


This is Nucleolar protein 56 protein, from Baker's yeast, contains 504 amino acids, locates in Nucleus.

Required for 60S ribosomal subunit synthesis


This is Serine/threonine-protein phosphatase 2A activator 2 protein, from Baker's yeast, contains 358 amino acids, is soluble, locates in Cytoplasm.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase, Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex, Acts also inhibitory at high concentrations, Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis


This is tRNA (guanine(10)-N2)-methyltransferase protein, from Baker's yeast, contains 433 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs

Belongs to the class I-like SAM-binding methyltransferase superfamily, TRM11 methyltransferase family


This is RuvB-like protein 2 protein, from Baker's yeast, contains 471 amino acids, is soluble, locates in Nucleus.

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes, The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling, The INO80 complex remodels chromatin by shifting nucleosomes, Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates, The INO80 complex is involved in DNA repair by associating to 'Ser-129' phosphorylated H2A histones as a response to DNA damage, During transcription may recruit SPT15/TBP to the TATA-boxes of involved genes, Required for box C/D and box H/ACA snoRNA accumulation and involved in pre-rRNA processing


This is Ferric reductase transmembrane component 6 protein, from Baker's yeast, contains 712 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Metalloreductase responsible for reducing vacuolar iron and copper prior to transport into the cytosol, Catalyzes the reduction of Fe(3+) to Fe(2+) and Cu(2+) to Cu(+), respectively, which can then be transported by the respective vacuolar efflux systems to the cytosol


This is Protein AIR2 protein, from Baker's yeast, contains 344 amino acids, has 3 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

CCHC-type

CCHC-type

Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information, Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met, Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome, AIR2 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1


This is rRNA biogenesis protein RRP36 protein, from Baker's yeast, contains 300 amino acids, locates in Nucleus.

Component of the 90S pre-ribosome involved in the maturation of rRNAs, Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway


This is Mitochondrial aspartate-glutamate transporter AGC1 protein, from Baker's yeast, contains 902 amino acids, is membrane-bound, locates in Mitochondrion.

Calcium-dependent mitochondrial aspartate and glutamate carrier, Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis, Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Nucleolar protein 58 protein, from Baker's yeast, contains 511 amino acids, locates in Nucleus.

Required for pre-18S rRNA processing, May bind microtubules


This is E3 ubiquitin-protein ligase RMD5 protein, from Baker's yeast, contains 421 amino acids, has 1 RING-Gid-type Zinc finger, is soluble, locates in Cytoplasm.

RING-Gid-type

E3 ubiquitin-protein ligase component of the GID complex (PubMed:12686616, PubMed:18508925), Required for the adaptation to the presence of glucose in the growth medium; mediates the degradation of enzymes involved in gluconeogenesis when cells are shifted to glucose-containing medium (PubMed:9737955, PubMed:18508925), Required for proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBP1) (PubMed:9737955, PubMed:12686616, PubMed:18508925, PubMed:28126757)


This is [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial protein, from Baker's yeast, contains 572 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the dephosphorylation and concomitant reactivation of the E1 alpha subunit (PDA1) of the pyruvate dehydrogenase complex


This is mRNA-decapping enzyme subunit 1 protein, from Baker's yeast, contains 231 amino acids, is soluble, locates in Cytoplasm.

Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay, Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP, Decapping is the major pathway of mRNA degradation in yeast, It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body, DCP1 is activated by the DEAD-box helicase DHH1 and destabilizes the eIF-4F cap-binding complex from the mRNA


This is Serine/threonine-protein kinase ksg1 protein, from Fission yeast, contains 592 amino acids, is soluble, locates in Cytoplasm.

Involved in the control of sexual development and cell growth under stressed conditions, Phosphorylates AGC kinase gad8 at 'Thr-387', activating gad8 kinase activity and promoting sexual development (PubMed:12805221), Phosphorylates AGC kinase psk1 at 'Ser-248', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6 (PubMed:22976295)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PDPK1 subfamily


This is Protein transport protein SEC39 protein, from Baker's yeast, contains 709 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for protein transport between the Golgi and the endoplasmic reticulum, May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex


This is Transducin beta-like protein 3 protein, from Human, contains 808 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome


This is Cell division cycle protein 20 homolog protein, from Human, contains 499 amino acids, is soluble, locates in Cytoplasm.

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex, Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates, The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons, CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation

Belongs to the WD repeat CDC20/Fizzy family


This is POU domain, class 4, transcription factor 2 protein, from Human, contains 409 amino acids, locates in Nucleus.

Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:19266028, PubMed:23805044), Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:19266028, PubMed:23805044), Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes, Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation, Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding, Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification, In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis, Negatively regulates BAX promoter activity in the absence of TP53, Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter, Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif, Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity)

Belongs to the POU transcription factor family, Class-4 subfamily


This is Hyaluronidase-2 protein, from Human, contains 473 amino acids, is membrane-bound, locates in Cell membrane.

Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides, Displays very low levels of activity, Associates with and negatively regulates MST1R

Belongs to the glycosyl hydrolase 56 family


This is Transmembrane protein 115 protein, from Human, contains 351 amino acids, is membrane-bound, locates in Golgi apparatus.

May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum, May indirectly play a role in protein glycosylation in the Golgi


This is Heat shock protein 75 kDa, mitochondrial protein, from Human, contains 704 amino acids, is membrane-bound, locates in Mitochondrion.

Chaperone that expresses an ATPase activity, Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I, Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis, The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Belongs to the heat shock protein 90 family


This is Transcription initiation factor TFIID subunit 10 protein, from Human, contains 218 amino acids, locates in Nucleus.

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473), TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473), The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473), TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (PubMed:18206972, PubMed:11564863, PubMed:9885574, PubMed:10373431, PubMed:12601814), May regulate cyclin E expression (By similarity)


This is Cell division cycle protein 16 homolog protein, from Human, contains 620 amino acids, is soluble, locates in Cytoplasm.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains


This is Zinc finger and BTB domain-containing protein 17 protein, from Human, contains 803 amino acids, has 13 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression, Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment, Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription, Required for early embryonic development during gastrulation, Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Ubiquitin carboxyl-terminal hydrolase 4 protein, from Human, contains 963 amino acids, locates in Cytoplasm.

Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403, PubMed:28604766), Deubiquitinates PDPK1 (PubMed:22347420), Deubiquitinates TRIM21 (PubMed:16316627), Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847), Deubiquitinates HAS2 (PubMed:28604766), May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234), This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6,U5 snRNP (PubMed:20595234), May also play a role in the regulation of quality control in the ER (PubMed:16339847)

Belongs to the peptidase C19 family, USP4 subfamily


This is Chromatin assembly factor 1 subunit A protein, from Human, contains 956 amino acids, locates in Nucleus.

Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair, Assembles histone octamers onto replicating DNA in vitro, CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer, It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci


This is Oxysterols receptor LXR-alpha protein, from Human, contains 447 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920), Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity), LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity), Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530), Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity), Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity), Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles, Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Replication protein A 30 kDa subunit protein, from Human, contains 261 amino acids, locates in Nucleus.

As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair, Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase, The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange

Belongs to the replication factor A protein 2 family


This is cGMP-dependent protein kinase 2 protein, from Human, contains 762 amino acids, is membrane-bound, locates in Cell membrane.

Crucial regulator of intestinal secretion and bone growth, Phosphorylates and activates CFTR on the plasma membrane, Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379), Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity, Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity), Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts, Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, cGMP subfamily


This is Serine/arginine-rich splicing factor 9 protein, from Human, contains 221 amino acids, locates in Nucleus.

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites, Represses the splicing of MAPT/Tau exon 10

Belongs to the splicing factor SR family


This is Serine/arginine-rich splicing factor 6 protein, from Human, contains 344 amino acids, locates in Nucleus.

Plays a role in constitutive splicing and modulates the selection of alternative splice sites, Plays a role in the alternative splicing of MAPT/Tau exon 10, Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC, Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing


This is Transcription intermediary factor 1-beta protein, from Human, contains 835 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger, has 1 PHD-type Zinc finger, locates in Nucleus.

RING-type

B box-type 1; atypical

B box-type

PHD-type

(Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection, This inhibition is mediated through interaction with herpes virus 8 protein LANA1


This is Steroidogenic factor 1 protein, from Human, contains 461 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Transcriptional activator, Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692), Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B, Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes, 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692), The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity, Binds phosphatidylcholine (By similarity), Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3, Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation

Belongs to the nuclear hormone receptor family, NR5 subfamily


This is Polyadenylate-binding protein 4 protein, from Human, contains 644 amino acids, is soluble, locates in Cytoplasm.

Binds the poly(A) tail of mRNA, May be involved in cytoplasmic regulatory processes of mRNA metabolism, Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)

Belongs to the polyadenylate-binding protein type-1 family


This is Cyclin-dependent kinase 5 activator 2 protein, from Human, contains 367 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the cyclin-dependent kinase 5 activator family


This is Urea transporter 1 protein, from Human, contains 389 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes (PubMed:7989337, PubMed:10514515, PubMed:7797558, PubMed:8997401), Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity), Facilitates water transport in erythrocytes (By similarity)


This is Krueppel-like factor 1 protein, from Human, contains 362 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis, Is a dual regulator of fetal-to-adult globin switching, Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene, Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes, This dual activity ensures that, in most adults, fetal hemoglobin levels are low, Able to activate CD44 and AQP1 promoters, When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation


This is RING-type E3 ubiquitin-protein ligase PPIL2 protein, from Human, contains 520 amino acids, locates in Nucleus.

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates, By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423), May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952), Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357), As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Belongs to the cyclophilin-type PPIase family, PPIL2 subfamily


This is Ubiquitin-conjugating enzyme E2 variant 1 protein, from Human, contains 147 amino acids, locates in Nucleus.

Has no ubiquitin ligase activity on its own, The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63, This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome, Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2, Mediates transcriptional activation of target genes, Plays a role in the control of progress through the cell cycle and differentiation, Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage, Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531), UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway

Belongs to the ubiquitin-conjugating enzyme family


This is DNA repair protein XRCC4 protein, from Human, contains 336 amino acids, locates in Nucleus.

Acts as an activator of the phospholipid scramblase activity of XKR4 (PubMed:33725486), This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface (PubMed:33725486)

Belongs to the XRCC4-XLF family, XRCC4 subfamily


This is Peptidyl-prolyl cis-trans isomerase G protein, from Human, contains 754 amino acids, is soluble, locates in Nucleus.

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357), May be implicated in the folding, transport, and assembly of proteins, May play an important role in the regulation of pre-mRNA splicing


This is Protein unc-119 homolog A protein, from Human, contains 240 amino acids, is soluble, locates in Cytoplasm.

Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins, Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization, Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons, Probably plays a role in trafficking proteins in photoreceptor cells, Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A


This is Zinc transporter ZIP6 protein, from Human, contains 755 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a zinc-influx transporter (PubMed:12839489), When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:27274087), SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246)

Belongs to the ZIP transporter (TC 2,A,5) family


This is Protein OS-9 protein, from Human, contains 667 amino acids, is soluble, locates in Endoplasmic reticulum.

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD), May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation, Possible targets include TRPV4


This is Forkhead box protein E3 protein, from Human, contains 319 amino acids, locates in Nucleus.

Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734), During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity), Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity), Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149)


This is Histone deacetylase 1 protein, from Human, contains 482 amino acids, locates in Nucleus.

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:16762839, PubMed:17704056, PubMed:28497810), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:16762839, PubMed:17704056), Histone deacetylases act via the formation of large multiprotein complexes (PubMed:16762839, PubMed:17704056), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666), Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 (PubMed:12837748, PubMed:16478997, PubMed:17996965, PubMed:19343227), Deacetylates SP proteins, SP1 and SP3, and regulates their function (PubMed:12837748, PubMed:16478997), Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (PubMed:19081374), Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (PubMed:19081374), Deacetylates TSHZ3 and regulates its transcriptional repressor activity (PubMed:19343227), Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (PubMed:17000776), Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (PubMed:17996965), Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity), Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity), Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity), In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810)

Belongs to the histone deacetylase family, HD type 1 subfamily


This is NEDD8-activating enzyme E1 regulatory subunit protein, from Human, contains 534 amino acids, is membrane-bound, locates in Cell membrane.

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme, E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP, E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M, Necessary for cell cycle progression through the S-M checkpoint, Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation, The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development

Belongs to the ubiquitin-activating E1 family, ULA1 subfamily


This is G/T mismatch-specific thymine DNA glycosylase protein, from Human, contains 410 amino acids, locates in Nucleus.

DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine, Cannot remove 5-hydroxymethylcytosine (5hmC), According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC, Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches, Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation, It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine, In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T, It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA, It can also remove uracil and 5-bromouracil from mispairs with guanine

Belongs to the uracil-DNA glycosylase (UDG) superfamily, TDG/mug family