This is Large ribosomal subunit protein eL14B protein, from Baker's yeast, contains 138 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL14 family


This is RNA-binding protein MIP6 protein, from Baker's yeast, contains 659 amino acids, is soluble, locates in Cytoplasm.


This is Box C/D snoRNA protein 1 protein, from Baker's yeast, contains 366 amino acids, has 1 HIT-type Zinc finger, locates in Nucleus.

HIT-type

Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis


This is Small ribosomal subunit protein mS41 protein, from Baker's yeast, contains 130 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081), mS41 is involved in telomere length regulation and required for survival upon exposure to K1 killer toxin (PubMed:12663529, PubMed:16552446)

Belongs to the mitochondrion-specific ribosomal protein mS41 family


This is Ribosome biogenesis protein SSF1 protein, from Baker's yeast, contains 453 amino acids, locates in Nucleus.

Required for biogenesis of the 60S ribosomal subunit


This is Phosphatidylglycerophosphatase GEP4, mitochondrial protein, from Baker's yeast, contains 185 amino acids, is membrane-bound, locates in Mitochondrion.

Phosphatidylglycerophosphatase involved in the biosynthesis of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes and which has important functions for cellular energy metabolism, mitochondrial dynamics and the initiation of apoptotic pathways, Required for the stability of respiratory chain supercomplexes and for growth at elevated temperature, in presence of ethidium bromide or in absence of prohibitins


This is Thioredoxin reductase 2, mitochondrial protein, from Baker's yeast, contains 342 amino acids, locates in Mitochondrion.

Acts on mitochondrial thioredoxin 3, Implicated in the defense against oxidative stress

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family


This is Cytochrome c lysine N-methyltransferase 1 protein, from Baker's yeast, contains 585 amino acids, is soluble, locates in Cytoplasm.

Methyltransferase which mediates trimethylation of 'Lys-78' of cytochrome c (CYC1)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Inactive metallocarboxypeptidase ECM14 protein, from Baker's yeast, contains 430 amino acids, locates in Lysosome/Vacuole.

Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis


This is Protein NSG1 protein, from Baker's yeast, contains 291 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation, Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation


This is GTPase MTG2, mitochondrial protein, from Baker's yeast, contains 518 amino acids, is membrane-bound, locates in Mitochondrion.

Required for mitochondrial protein synthesis, May be involved in mitochondrial ribosome biogenesis

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family


This is 60S ribosomal export protein NMD3 protein, from Baker's yeast, contains 518 amino acids, locates in Cytoplasm.

Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit, Unlikely to play a significant role in nonsense-mediated mRNA decay (NMD)


This is Copper transport protein CTR2 protein, from Baker's yeast, contains 189 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Provides bioavailable copper via mobilization of vacuolar copper stores and export to the cytoplasm

Belongs to the copper transporter (Ctr) (TC 1,A,56) family, SLC31A subfamily


This is Probable S-adenosylmethionine-dependent methyltransferase CRG1 protein, from Baker's yeast, contains 291 amino acids, is soluble, locates in Cytoplasm.

Probable S-adenosylmethionine-dependent methyltransferase which mediates cantharidin resistance

Belongs to the methyltransferase superfamily


This is Cytochrome c mitochondrial import factor CYC2 protein, from Baker's yeast, contains 366 amino acids, is membrane-bound, locates in Mitochondrion.

Redox component that participates in c-type cytochrome biogenesis in the mitochondrial intermembrane space, May play a role in the reduction of heme prior to its ligation to apocytochrome c by cytochrome c heme lyase, Has oxidoreductase activity in vitro


This is DNA polymerase zeta processivity subunit protein, from Baker's yeast, contains 245 amino acids, locates in Mitochondrion.

Required for DNA damage induced mutagenesis, Involved in DNA repair, mitochondrial DNA repair and translesion synthesis, Has a role in the bypass of abasic (AP) sites


This is Golgi apparatus membrane protein TVP23 protein, from Baker's yeast, contains 199 amino acids, is membrane-bound, locates in Golgi apparatus.

Golgi membrane protein involved in vesicular trafficking


This is Mitochondrial GTP/GDP carrier protein 1 protein, from Baker's yeast, contains 300 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial GTP/GDP transporter required for GTP uptake and GDP exit from mitochondria, Involved in mitochondrial iron transport and essential for mitochondrial genome maintenance

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is DnaJ protein homolog XDJ1 protein, from Baker's yeast, contains 459 amino acids, has 1 CR-type Zinc finger, is membrane-bound, locates in Mitochondrion.

CR-type


This is Ribosome-releasing factor 2, mitochondrial protein, from Baker's yeast, contains 819 amino acids, locates in Mitochondrion.

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis, Not involved in the GTP-dependent ribosomal translocation step during translation elongation (By similarity), Required for respiratory growth and essential for mitochondrial genome maintenance

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily


This is GLC7-interacting protein 4 protein, from Baker's yeast, contains 760 amino acids, is soluble, locates in Cytoplasm.

GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation


This is Protein HPH2 protein, from Baker's yeast, contains 528 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for growth under high NaCl, alkaline pH and cell wall stress


This is Protein PTI1 protein, from Baker's yeast, contains 425 amino acids, locates in Nucleus.

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation, PTI1 is required for 3'-end formation of snoRNAs


This is Small ribosomal subunit protein eS26A protein, from Baker's yeast, contains 119 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eS26 family


This is Small ribosomal subunit protein eS26B protein, from Baker's yeast, contains 119 amino acids, is soluble, locates in Cytoplasm.


This is Heat shock protein SSC3, mitochondrial protein, from Baker's yeast, contains 644 amino acids, is soluble, locates in Mitochondrion.

Plays a role in facilitating the assembly of some protein complexes inside the mitochondria, It may initiate the events that lead to refolding of imported precursors in the matrix space

Belongs to the heat shock protein 70 family


This is Putative 2-hydroxyacyl-CoA lyase protein, from Baker's yeast, contains 560 amino acids, is soluble, locates in Cytoplasm.

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde


This is UDP-N-acetylglucosamine transporter YEA4 protein, from Baker's yeast, contains 342 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) and is required for cell wall chitin synthesis

Belongs to the nucleotide-sugar transporter family, SLC35B subfamily


This is Prefoldin subunit 2 protein, from Baker's yeast, contains 111 amino acids, is soluble, locates in Cytoplasm.

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it, Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins

Belongs to the prefoldin subunit beta family


This is Nucleolar protein 16 protein, from Baker's yeast, contains 231 amino acids, locates in Nucleus.

Involved in the biogenesis of the 60S ribosomal subunit


This is Protoporphyrinogen oxidase protein, from Baker's yeast, contains 539 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX

Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family, Protoporphyrinogen oxidase subfamily


This is Carnitine O-acetyltransferase YAT2 protein, from Baker's yeast, contains 923 amino acids, is soluble, locates in Cytoplasm.

Carnitine O-acetyltransferase involved in the shutteling of acetyl-CoA in the cell

Belongs to the carnitine/choline acetyltransferase family


This is Sporulation-specific protein 73 protein, from Baker's yeast, contains 143 amino acids, is soluble, locates in Cytoplasm.

Required for spore wall assembly and ascus formation (PubMed:11470404, PubMed:15590821), Involved in the formation and elongation of prospore membranes (PubMed:26605945, PubMed:27303688)


This is Small ribosomal subunit protein bS18m protein, from Baker's yeast, contains 138 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the bacterial ribosomal protein bS18 family


This is Mitochondrial phosphate carrier protein 2 protein, from Baker's yeast, contains 300 amino acids, is membrane-bound, locates in Mitochondrion.

Transport of phosphate groups from the cytosol to the mitochondrial matrix


This is Respiratory growth induced protein 1 protein, from Baker's yeast, contains 161 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions


This is Transmembrane 9 superfamily member 3 protein, from Baker's yeast, contains 706 amino acids, is membrane-bound, locates in Golgi apparatus.

With EMP70 and TMN2, plays a critical role in the late stages of a nutrient-controlled pathway notably regulating FLO11 gene expression, Acts downstream of RAS2 and TOR, Essential for cell adhesion and filamentous growth, May play a role as effector of cellular copper homeostasis

Belongs to the nonaspanin (TM9SF) (TC 9,A,2) family


This is Vacuolar amino acid transporter 6 protein, from Baker's yeast, contains 448 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Involved in amino acid efflux from the vacuole to the cytoplasm, Capable of transporting aspartate and glutamate, Requires ATP for function

Belongs to the amino acid/polyamine transporter 2 family


This is 5-formyltetrahydrofolate cyclo-ligase protein, from Baker's yeast, contains 211 amino acids, locates in Mitochondrion.

Only enzyme known to utilize 5-formyltetrahydrofolate (folinic acid) as substrate, Contributes to tetrahydrofolate metabolism in an alternative way of folate biosynthesis, May regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids

Belongs to the 5-formyltetrahydrofolate cyclo-ligase family


This is Ino eighty subunit 2 protein, from Baker's yeast, contains 320 amino acids, locates in Nucleus.

Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair


This is Uncharacterized plasma membrane protein YNL194C protein, from Baker's yeast, contains 301 amino acids, is membrane-bound, locates in Cell membrane.

Involved in sporulation and affects the sphingolipid composition of the plasma membrane


This is Protein MMF1, mitochondrial protein, from Baker's yeast, contains 145 amino acids, is soluble, locates in Mitochondrion.

Plays a role in the maintenance of mitochondrial DNA


This is Large ribosomal subunit protein eL13B protein, from Baker's yeast, contains 199 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL13 family


This is S-formylglutathione hydrolase protein, from Baker's yeast, contains 299 amino acids, is soluble, locates in Cytoplasm.

Serine hydrolase involved in the detoxification of formaldehyde


This is Protein DLS1 protein, from Baker's yeast, contains 167 amino acids, locates in Nucleus.

Functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA, The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing, It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex, DLS1 is partially required for the ISW2 complex chromatin remodeling activity and is not required for its interaction with chromatin


This is Cell division cycle protein cdt1 protein, from Fission yeast, contains 444 amino acids, locates in Nucleus.

DNA replication licensing factor, required for pre-replication complex assembly, Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation, Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication, Required for the recruitment of the MCM helicase complex to the replication origins


This is Activator of stress genes 1 protein, from Baker's yeast, contains 964 amino acids, locates in Nucleus.

Probable transcription factor involved in the stress response


This is 25S rRNA (uridine(2634)-N(3))-methyltransferase protein, from Baker's yeast, contains 336 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(3) position of uridine 2634 (m3U2634) in 25S rRNA

Belongs to the class I-like SAM-binding methyltransferase superfamily, BMT5 family


This is Protein ICE2 protein, from Baker's yeast, contains 491 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Protein-lysine N-methyltransferase EFM4 protein, from Baker's yeast, contains 257 amino acids, is soluble, locates in Cytoplasm.

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha (TEF1 and TEF2) at 'Lys-316', May play a role in intracellular transport

Belongs to the class I-like SAM-binding methyltransferase superfamily, EFM4 family


This is Actin-related protein 2/3 complex subunit 5 protein, from Baker's yeast, contains 154 amino acids, is soluble, locates in Cytoplasm.

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks


This is Protein SYG1 protein, from Baker's yeast, contains 902 amino acids, is membrane-bound, locates in Cell membrane.

May function in G-protein coupled signal transduction


This is Inner membrane assembly complex subunit 22 protein, from Baker's yeast, contains 216 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase, INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain


This is Kappa-type opioid receptor protein, from Guinea pig, contains 380 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins, Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling leads to the inhibition of adenylate cyclase activity, Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, Plays a role in the perception of pain, Plays a role in mediating reduced physical activity upon treatment with synthetic opioids, Plays a role in the regulation of salivation in response to synthetic opioids, May play a role in arousal and regulation of autonomic and neuroendocrine functions

Belongs to the G-protein coupled receptor 1 family


This is Histone H3.3 protein, from Tetrahymena thermophila (strain SB210), contains 136 amino acids, locates in Nucleus.

Macronuclear replacement variant which replaces conventional H3 in a subset of nucleosomes, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling, Functions redundantly to H3,4, H3,3 deposition into chromatin is mainly transcription-associated and DNA replication-independent, but it can also enter a replication-coupled pathway, Although not essential for vegetative growth, minor H3 variants are required for producing viable conjugation progeny by affecting late developmental stages of conjugation


This is Aspergillopepsin-1 protein, from Neosartorya fumigata, contains 395 amino acids, is soluble, locates in Extracellular.

Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates, The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site, Shows a broad primary substrate specificity, Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A (By similarity), Can catalyze hydrolysis of the major structural proteins of basement membrane, elastin, collagen, and laminin, Thought to play a significant role in virulence (PubMed:7558282)


This is tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 protein, from Baker's yeast, contains 478 amino acids, locates in Nucleus.

Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:10779558, PubMed:9851972), Also required for repression of GCN4 mRNA translation by the upstream open reading frames (uORFs) under conditions of amino acid sufficiency (PubMed:7542616)


This is Ribose-phosphate pyrophosphokinase 1 protein, from Fission yeast, contains 409 amino acids, is soluble, locates in Cytoplasm.

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis, Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity)

Belongs to the ribose-phosphate pyrophosphokinase family


This is Poly(A)+ RNA export protein protein, from Fission yeast, contains 352 amino acids, locates in Nucleus.

Required for mitotic cell growth as well as for spore germination, Functions in cell cycle progression through trafficking of proteins required for mitosis, Has a role in the mRNA export process


This is Thiamine pyrophosphokinase protein, from Fission yeast, contains 569 amino acids, is soluble, locates in Cytoplasm.

Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth


This is Ras modification protein ERF4 protein, from Baker's yeast, contains 237 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

The ERF2-SHR5 complex is a palmitoyltransferase specific for Ras proteins (PubMed:12193598, PubMed:12379641, PubMed:7532279), Palmitoylates RAS2, which is required for its proper plasma membrane localization (PubMed:12193598, PubMed:12379641, PubMed:7532279)


This is GTP-binding nuclear protein Ran-2 protein, from Mouse-ear cress, contains 221 amino acids, locates in Nucleus.

GTP-binding protein involved in nucleocytoplasmic transport, Required for the import of protein into the nucleus and also for RNA export, Involved in chromatin condensation and control of cell cycle (By similarity)

Belongs to the small GTPase superfamily, Ran family


This is Sulfite efflux pump SSU1 protein, from Baker's yeast, contains 458 amino acids, is membrane-bound, locates in Cell membrane.

Involved in efflux of free sulfite, Mutations in the SSU1 gene cause sensitivity to sulfite

Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family


This is Mannose-1-phosphate guanyltransferase protein, from Baker's yeast, contains 361 amino acids, is soluble, locates in Cytoplasm.

Involved in cell wall synthesis where it is required for glycosylation, Involved in cell cycle progression through cell-size checkpoint

Belongs to the transferase hexapeptide repeat family


This is Superoxide dismutase [Mn] 2, mitochondrial protein, from Caenorhabditis elegans, contains 218 amino acids, locates in Mitochondrion.

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems

Belongs to the iron/manganese superoxide dismutase family


This is Vitellogenic carboxypeptidase protein, from Yellowfever mosquito, contains 471 amino acids, is soluble, locates in Extracellular.

May play a role in activating hydrolytic enzymes that are involved in the degradation of yolk proteins in developing embryos or may function as an exopeptidase in the degradation of vitellogenin


This is RNA-binding protein 34 protein, from Human, contains 430 amino acids, locates in Nucleus.


This is G-box-binding factor 4 protein, from Mouse-ear cress, contains 270 amino acids, locates in Nucleus.

Binds to the G-box motif (5'-CCACGTGG-3') of the rbcS-1A gene promoter, G-box and G-box-like motifs are cis-acting elements defined in promoters of certain plant genes which are regulated by such diverse stimuli as light-induction or hormone control


This is Polyadenylation factor subunit 2 protein, from Baker's yeast, contains 465 amino acids, locates in Nucleus.

Integral and essential component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, May bridge the CPF and CFIA complexes


This is F-box protein SKP2 protein, from Baker's yeast, contains 763 amino acids, is soluble, locates in Cytoplasm.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Probably recognizes and binds to phosphorylated target proteins (By similarity), Regulates protein levels of sulfur metabolism enzymes, The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis


This is Protein KRI1 protein, from Baker's yeast, contains 591 amino acids, locates in Nucleus.

Required for 40S ribosome biogenesis, Involved in nucleolar processing of pre-18S ribosomal RNA


This is Small ribosomal subunit protein uS11m protein, from Baker's yeast, contains 217 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uS11 family


This is Non-structural maintenance of chromosome element 4 protein, from Baker's yeast, contains 402 amino acids, locates in Nucleus.

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks


This is Melanoma-associated antigen 10 protein, from Human, contains 369 amino acids, locates in Nucleus.

Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression


This is Membrane-anchored lipid-binding protein LAM5 protein, from Baker's yeast, contains 674 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in sterol transfer between intracellular membranes


This is Ino eighty subunit 1 protein, from Baker's yeast, contains 692 amino acids, locates in Nucleus.

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex


This is Pre-mRNA-splicing factor SAD1 protein, from Baker's yeast, contains 448 amino acids, has 1 UBP-type; degenerate Zinc finger, locates in Nucleus.

UBP-type; degenerate

Promotes the assembly of newly synthesized U4 snRNA into the U4/U6 snRNP particle, Required for splicing of pre-mRNA


This is SPS-sensor component PTR3 protein, from Baker's yeast, contains 678 amino acids, is membrane-bound, locates in Cell membrane.

Component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2


This is Beta-1,6-glucan synthesis-associated protein KEG1 protein, from Baker's yeast, contains 200 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the biosynthesis of (1->6)-beta-D-glucan polymers of the cell wall, Required for viability, Involved in maintaining chromosome stability


This is Y-box-binding protein 2-B protein, from African clawed frog, contains 324 amino acids, is soluble, locates in Cytoplasm.

Putative translation regulator, May be involved in the developmental translational regulation of maternal mRNAs


This is Beta-toxin Cn5 protein, from Mexican scorpion, contains 87 amino acids, is soluble, locates in Extracellular.

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing, This toxin is lethal to crustaceans (freshwater crayfish (Cambarellus montezumae spp,)), it provokes a reversible paralysis to insects (crickets (Achaeta spp,)), but is not toxic to mice, At high concentrations, it does displace the (beta) mammal-specific toxin Cn2 from rat brain synaptosomes

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Mevalonate kinase protein, from Mouse-ear cress, contains 378 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis

Belongs to the GHMP kinase family, Mevalonate kinase subfamily


This is Solute carrier family 2, facilitated glucose transporter member 5 protein, from Rabbit, contains 486 amino acids, is membrane-bound, locates in Cell membrane.

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:7980458), Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity), Essential for fructose uptake in the small intestine, Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose, Required for the development of high blood pressure in response to high dietary fructose intake (By similarity)

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily


This is Homeobox-leucine zipper protein HAT22 protein, from Mouse-ear cress, contains 278 amino acids, locates in Nucleus.

Belongs to the HD-ZIP homeobox family, Class II subfamily


This is Factor arrest protein 3 protein, from Baker's yeast, contains 204 amino acids, locates in Endoplasmic reticulum.

Participates in the control of the reentry into the cell cycle following pheromone treatment


This is Alpha-1,2-mannosyltransferase MNN5 protein, from Baker's yeast, contains 586 amino acids, locates in Golgi apparatus.

Responsible for addition of first and second mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose, Implicated in late Golgi modifications


This is Prefoldin subunit 1 protein, from Baker's yeast, contains 109 amino acids, is soluble, locates in Cytoplasm.

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it, Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins

Belongs to the prefoldin subunit beta family


This is GPI mannosyltransferase 1 protein, from Baker's yeast, contains 403 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly, Required for cell wall integrity


This is Actin-related protein 3 protein, from Baker's yeast, contains 449 amino acids, is soluble, locates in Cytoplasm.

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks, Seems to contact the pointed end of the daughter actin filament (By similarity)

Belongs to the actin family, ARP3 subfamily


This is Nuclear import protein MOG1 protein, from Baker's yeast, contains 218 amino acids, locates in Nucleus.

Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export


This is ER membrane protein complex subunit 2 protein, from Baker's yeast, contains 292 amino acids, locates in Endoplasmic reticulum.

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151), Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151), Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151), It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes, By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity)


This is Phosphoinositide 3-phosphatase protein, from Baker's yeast, contains 688 amino acids, is soluble, locates in Cytoplasm.

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P), Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is Kinetochore-associated protein NNF1 protein, from Baker's yeast, contains 201 amino acids, locates in Nucleus.

Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity, MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules, NNF1 is required for a number of nuclear functions, Cells depleted of NNF11 or containing a temperature-sensitive NNF1 mutation have elongated microtubules and become bi- and multinucleate, They also have a fragmented nucleolus and accumulate poly(A)+ RNA inside the nucleus


This is Metaxin-1 protein, from Mouse, contains 317 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in transport of proteins into the mitochondrion, Essential for embryonic development


This is Peptidyl-prolyl cis-trans isomerase Fkbp12 protein, from Fruit fly, contains 108 amino acids, is soluble, locates in Cytoplasm.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor, Binding is inhibitory to the signaling pathways of the TGF beta family ligands

Belongs to the FKBP-type PPIase family, FKBP1 subfamily


This is Serine/threonine-protein phosphatase PP-X isozyme 2 protein, from Mouse-ear cress, contains 305 amino acids, is soluble, locates in Plastid.

Belongs to the PPP phosphatase family, PP-4 (PP-X) subfamily


This is Eukaryotic translation initiation factor 4E protein, from African clawed frog, contains 213 amino acids, is soluble, locates in Cytoplasm.

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:10635326), In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (By similarity), Maternal RNA in oocytes remain in a dormant state as tacc3/maskin outcompetes eif4g to bind eif4e, thereby preventing translation (PubMed:10635326), During oocyte maturation this complex dissolves and eif4g binds eif4e to allow translation of maternal RNAs (PubMed:10635326)

Belongs to the eukaryotic initiation factor 4E family


This is Omega-6 fatty acid desaturase, chloroplastic protein, from Spinach, contains 447 amino acids, is membrane-bound, locates in Plastid.

Chloroplast omega-6 fatty acid desaturase introduces the second double bond in the biosynthesis of 16:3 and 18:3 fatty acids, important constituents of plant membranes, It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol

Belongs to the fatty acid desaturase type 1 family


This is Light-mediated development protein DET1 protein, from Mouse-ear cress, contains 543 amino acids, locates in Nucleus.

Component of light signal transduction machinery, Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s), Involved in repression of deetiolation in the developing seedling, Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5, HYH and LAF1, Involved in the repression of blue light responsive promoter in chloroplasts, May be required to stabilize the CDD complex, Its association with histone tail suggests a role in remodeling of chromatin (PubMed:9681024, PubMed:15342494), Required for the regulation of histone H2B monoubiquitination (H2Bub) over most genes by controlling the stability of the deubiquitination module (DUB module) (PubMed:30192741)


This is Endochitinase 42 protein, from Hypocrea lixii, contains 423 amino acids, is soluble, locates in Extracellular.

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods), Plays a morphogenetic role during apical growth, cell division and differentiation (cell wall morphogenesis), Acts also as an antifungal agent, Involved in the degradation and further assimilation of phytopathogenic fungi, namely mycoparasitism, the major mechanism accounting for the antagonistic activity against phytopathogenic fungi displayed by Trichoderma

Belongs to the glycosyl hydrolase 18 family, Chitinase class V subfamily


This is 5-hydroxytryptamine receptor 1D protein, from Rabbit, contains 377 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling inhibits adenylate cyclase activity, Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity, May also play a role in regulating the release of other neurotransmitters, May play a role in vasoconstriction (By similarity)

Belongs to the G-protein coupled receptor 1 family


This is Large ribosomal subunit protein eL38 protein, from Baker's yeast, contains 78 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL38 family


This is Homoaconitase, mitochondrial protein, from Baker's yeast, contains 693 amino acids, locates in Mitochondrion.

Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis

Belongs to the aconitase/IPM isomerase family


This is Azole resistance protein 1 protein, from Baker's yeast, contains 613 amino acids, is membrane-bound, locates in Cell membrane.

Transporter protein required for adaptation to high stress imposed by low-chain organic acids, in particular by acetic acid, and for resistance to azoles, especially to ketoconazole and fluconazole

Belongs to the major facilitator superfamily


This is Protein PSP2 protein, from Baker's yeast, contains 593 amino acids, is soluble, locates in Cytoplasm.

DNA polymerase alpha mutation suppressor, Suppressor of group II intron splicing defects of a mutation in MRS2, May play a role in mitochondrial mRNA splicing


This is Transthyretin protein, from Pig, contains 150 amino acids, is soluble, locates in Extracellular.

Thyroid hormone-binding protein, Probably transports thyroxine from the bloodstream to the brain


This is Putative tyrosine-protein phosphatase OCA1 protein, from Baker's yeast, contains 238 amino acids, is soluble, locates in Cytoplasm.

Putative tyrosine-protein phosphatase required for protection against superoxide stress, Involved in cell-cycle delay in response to linoleic acid hydroperoxide (LoaOOH)

Belongs to the protein-tyrosine phosphatase family


This is Large ribosomal subunit protein uL6B protein, from Baker's yeast, contains 191 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uL6 family


This is Putative teratocarcinoma-derived growth factor 3 protein, from Human, contains 188 amino acids, is membrane-bound, locates in Cell membrane.

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm, Activates the Nodal-dependent signaling pathway

Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family


This is Cyclin-G1 protein, from Mouse, contains 294 amino acids, locates in Nucleus.

May play a role in growth regulation, Is associated with G2/M phase arrest in response to DNA damage, May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation

Belongs to the cyclin family, Cyclin G subfamily


This is Large ribosomal subunit protein uL4m protein, from Baker's yeast, contains 286 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uL4 family


This is Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic protein, from Mouse-ear cress, contains 236 amino acids, is soluble, locates in Plastid.

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione

Belongs to the glutathione peroxidase family


This is Probable alanine aminotransferase, mitochondrial protein, from Baker's yeast, contains 592 amino acids, is soluble, locates in Mitochondrion.

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily


This is Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial protein, from Mouse-ear cress, contains 389 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)


This is Nucleus export protein BRR6 protein, from Baker's yeast, contains 197 amino acids, is membrane-bound, locates in Nucleus.

Required for mRNA nuclear export, Involved in the nuclear pore complex (NPC) distribution and nuclear envelope morphology


This is ER membrane protein complex subunit 4 protein, from Baker's yeast, contains 190 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151), Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151), Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151), It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes, By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity)


This is Enhancer of mRNA-decapping protein 1 protein, from Baker's yeast, contains 175 amino acids, is soluble, locates in Cytoplasm.

mRNA-binding protein which stimulates mRNA decapping by DCP1 and DCP2, Involved in the regulation of expression of multiple genes involved in glycolysis and gluconeogenesis


This is Ran-specific GTPase-activating protein 30 protein, from Baker's yeast, contains 440 amino acids, locates in Cytoplasm.

Important for the export of protein containing nuclear export signal (NES) out of the nucleus, Stimulates the GTPase activity of GSP1


This is Putative flavin carrier protein 3 protein, from Baker's yeast, contains 802 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding

Belongs to the transient receptor potential (TRP) ion channel family


This is rRNA methyltransferase 2, mitochondrial protein, from Baker's yeast, contains 320 amino acids, locates in Mitochondrion.

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 2791 (Um2791) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA

Belongs to the class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family


This is PHO85 cyclin-10 protein, from Baker's yeast, contains 433 amino acids, is soluble, locates in Cytoplasm.

Cyclin partner of the cyclin-dependent kinase (CDK) PHO85, Together with cyclin PCL8, negatively controls glycogen accumulation under favorable growth conditions, The PCL10-PHO85 cyclin-CDK holoenzyme has glycogen synthase kinase activity and phosphorylates and negatively regulates glycogen synthase GSY2, Also has minor GLC8 kinase activity

Belongs to the cyclin family, PHO80 subfamily


This is Probable endonuclease LCL3 protein, from Baker's yeast, contains 274 amino acids, is membrane-bound, locates in Mitochondrion.


This is tRNA pseudouridine(27/28) synthase protein, from Baker's yeast, contains 370 amino acids, locates in Mitochondrion.

Mitochondrial-specific pseudouridine synthase catalyzing the formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of mitochondrial transfer RNAs

Belongs to the tRNA pseudouridine synthase TruA family


This is YAP1-binding protein 2 protein, from Baker's yeast, contains 641 amino acids, is soluble, locates in Cytoplasm.

Involved in oxidative stress response and redox homeostasis, Required for hydrogen peroxide-induced activation of YAP1, Acts in a parallele pathway to YBP1


This is Homologous-pairing protein 2 protein, from Baker's yeast, contains 214 amino acids, locates in Nucleus.

Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis, Stimulates DMC1-dependent homologous strand assimilation required for the resolution of meiotic double-strand breaks


This is rRNA-processing protein CGR1 protein, from Baker's yeast, contains 120 amino acids, locates in Nucleus.

Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit


This is Probable family 17 glucosidase SCW11 protein, from Baker's yeast, contains 542 amino acids, is soluble, locates in Extracellular.

Belongs to the glycosyl hydrolase 17 family


This is Probable alcohol acetyltransferase protein, from Baker's yeast, contains 342 amino acids, locates in Mitochondrion.

Probable alcohol acetyltransferase that uses acetyl-CoA to synthesize acetate esters from various alcohols (Probable), Not involved in the synthesis of ethyl acetate (PubMed:28356220)


This is Large ribosomal subunit protein uL24B protein, from Baker's yeast, contains 127 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the universal ribosomal protein uL24 family


This is Bud site selection protein 9 protein, from Baker's yeast, contains 547 amino acids, is membrane-bound, locates in Cell membrane.

May be involved in positioning the proximal bud pole signal


This is Probable serine/threonine-protein kinase FMP48 protein, from Baker's yeast, contains 369 amino acids, locates in Mitochondrion.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Cytochrome c oxidase assembly protein COX18, mitochondrial protein, from Baker's yeast, contains 316 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the insertion of integral membrane proteins into the mitochondrial inner membrane, Essential for the activity and assembly of cytochrome c oxidase, Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space


This is Late endosome and vacuole interface protein 11 protein, from Baker's yeast, contains 860 amino acids, has 1 BED-type Zinc finger, locates in Nucleus.

BED-type

Involved in vacuolar processing and morphology


This is Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial protein, from Baker's yeast, contains 183 amino acids, is membrane-bound, locates in Mitochondrion.

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria, The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln), Required for proper protein synthesis within the mitochondrion


This is Polyamine transporter 2 protein, from Baker's yeast, contains 614 amino acids, is membrane-bound, locates in Cell membrane.

Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm, Recognizes spermine, but not spermidine

Belongs to the major facilitator superfamily, DHA1 family, Polyamines/proton antiporter (TC 2,A,1,2,16) subfamily


This is Ribosome-interacting GTPase 2 protein, from Baker's yeast, contains 368 amino acids, is soluble, locates in Cytoplasm.

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family


This is Protein SDA1 protein, from Baker's yeast, contains 767 amino acids, locates in Nucleus.

Required for 60S pre-ribosomal subunits export to the cytoplasm, May also be required for 60S ribosomal subunit maturation and accumulation, Involved in G1 events and passage through start, and possibly actin cytoskeleton organization


This is RNA exonuclease 1 protein, from Baker's yeast, contains 553 amino acids, locates in Nucleus.

3' exoribonuclease required for 5S rRNA maturation and for the proper maturation of the 5' cistron of the tRNA-Arg3 dicistronic gene, Involved with REX2 in the maturation of the 5,8S rRNA, and with REX2 and REX3, in the 3' processing of the U5L snRNA


This is ER-derived vesicles protein ERV29 protein, from Baker's yeast, contains 310 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles, Required for efficient transport of a subset of secretory proteins to the Golgi, The C-terminal di-lysine motif is required for exit from the endoplasmic reticulum, Required directly for packaging glycosylated pro-alpha-factor into COPII vesicles, Facilitates retrograde transport from the Golgi to the endoplasmic reticulum


This is Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase protein, from Baker's yeast, contains 551 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation

Belongs to the glycosyltransferase 22 family


This is Small ribosomal subunit protein uS12m protein, from Baker's yeast, contains 153 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081), uS12m is required for respiratory growth (PubMed:11780787)

Belongs to the universal ribosomal protein uS12 family


This is Phosphatidylcholine transfer protein protein, from Mouse, contains 214 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the transfer of phosphatidylcholine between membranes, Binds a single lipid molecule


This is Zinc finger protein GIS2 protein, from Baker's yeast, contains 153 amino acids, has 7 CCHC-type Zinc finger, is soluble, locates in Cytoplasm.

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

CCHC-type

May act in the sexual differentiation pathway


This is Large ribosomal subunit protein uL11m protein, from Baker's yeast, contains 158 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uL11 family


This is Large ribosomal subunit protein bL35m protein, from Baker's yeast, contains 115 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bL35 family


This is N-glycosylation protein EOS1 protein, from Baker's yeast, contains 366 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in oxidative stress resistance and N-glycosylation


This is Mitochondrial MRF1 N(5)-glutamine methyltransferase MTQ1 protein, from Baker's yeast, contains 314 amino acids, locates in Mitochondrion.

Methylates MRF1 on 'Gln-287' using S-adenosyl L-methionine as methyl donor

Belongs to the protein N5-glutamine methyltransferase family


This is Oligoribonuclease, mitochondrial protein, from Baker's yeast, contains 269 amino acids, locates in Mitochondrion.

3'-to-5' exoribonuclease specific for small oligoribonucleotides


This is Endo-1,4-beta-xylanase A protein, from Aspergillus nidulans, contains 225 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is Endo-1,4-beta-xylanase B protein, from Aspergillus nidulans, contains 221 amino acids, is soluble, locates in Extracellular.


This is Glycoprotein Xg protein, from Human, contains 180 amino acids, is membrane-bound, locates in Cell membrane.


This is Potassium channel toxin alpha-KTx 4.2 protein, from Brazilian scorpion, contains 57 amino acids, is soluble, locates in Extracellular.

Blocker for small-conductance calcium-activated potassium channels KCa2,2/KCNN2 (Kd=80 nM) and KCa2,3/KCNN3 (Kd=197 nM) (PubMed:11527975) and ERG1/Kv11,1/KCNH2 potassium channels (53% inhibition at 5 uM) (PubMed:18687312), Has also been shown to inhibit Kv1,1/KCNA1 and Nav1,7/SCN9A with a moderate potency, as well as Kv11,1/KCNH2/ERG1 and Kv1,2/KCNA2 with a low potency (PubMed:29483648)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily


This is Cx9C motif-containing protein 4 protein, from Human, contains 68 amino acids, locates in Mitochondrion.


This is Large ribosomal subunit protein eL22B protein, from Baker's yeast, contains 122 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL22 family


This is Poly(rC)-binding protein 4 protein, from Human, contains 403 amino acids, is soluble, locates in Cytoplasm.

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC


This is Mitochondrial import inner membrane translocase subunit TIM8 protein, from Baker's yeast, contains 87 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane, Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane, Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space, The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins, Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria


This is Endoribonuclease YbeY protein, from Human, contains 167 amino acids, locates in Nucleus.

Single strand-specific metallo-endoribonuclease involved in rRNA maturation

Belongs to the endoribonuclease YbeY family


This is Lymphocyte antigen 96 protein, from Bovine, contains 160 amino acids, is soluble, locates in Extracellular.

Binds bacterial lipopolysaccharide (LPS), Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (By similarity), Enhances TLR4-dependent activation of NF-kappa-B, Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS


This is Conotoxin tx3c protein, from Cloth-of-gold cone, contains 65 amino acids, is soluble, locates in Extracellular.


This is Cobrotoxin-c protein, from Monocled cobra, contains 61 amino acids, is soluble, locates in Extracellular.

Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site, Binds to the nicotinic acetylcholine receptor

Belongs to the snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily


This is Alpha-like toxin Bom4 protein, from Moroccan scorpion, contains 65 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission, This alpha-like toxin is highly toxic to mice and insects

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily


This is GAMMA-ctenitoxin-Pn1a protein, from Brazilian armed spider, contains 81 amino acids, is soluble, locates in Extracellular.

This insecticidal neurotoxin targets two types of channels/receptors, It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) (PubMed:10978749), It inhibits glutamate uptake from rat brain synaptosomes, and blocks GRIN in hippocampal slices (PubMed:10978749, PubMed:26802625), It also acts on sodium channels of both insects and mammals (PubMed:26747232), On sodium channel insects, it strongly slows down channel inactivation (EC(50)=212,5 nM) and causes an increase (105%) in peak amplitude (at 1 uM) of B,germanica sodium channel (Nav), whereas it inhibits all mammalien sodium channels tested with the following order of potency: Nav1,3/SCN3A (IC(50)=1,5 uM) > Nav1,6/SCN8A > Nav1,5/SCN5A > Nav1,4/SCN4A >= Nav1,2/SCN2A (PubMed:26747232), In vivo, it is highly toxic to house fly (Musca domestica), cockroach (Periplaneta americana), and cricket (Acheta domesticus) (PubMed:10978749), In different rat pain models (induced by PGE2, carrageenan or glutamate), it shows antinociceptive effect that may be related to an inhibitory activity on the glutamatergic system (PubMed:31467512)

Belongs to the neurotoxin 03 (Tx2) family, 05 subfamily


This is Delta-ctenitoxin-Pn1a protein, from Brazilian armed spider, contains 82 amino acids, is soluble, locates in Extracellular.

This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation (PubMed:12770132), The toxin also inhibits glutamate uptake from rat brain synaptosomes (PubMed:14757211), It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) (By similarity), In addition, the toxin shows antinociceptive effect in all rat pain models tested (inflammatory, neuropathic and nociceptive) (PubMed:27077886), The antinociceptive effect is partially blocked when selective antagonists of both mu- and delta-opioid receptors are administered, revealing that the antinociceptive effect of the toxin involves both opiod and cannabinoid endogenous systems (PubMed:27077886), In vivo, it is highly toxic to house fly (Musca domestica), toxic to cockroach, but has no effect when intracerebroventricularly injected into mice (PubMed:7778132, PubMed:12770132)


This is Zinc transporter ZIP1 protein, from Zebrafish, contains 302 amino acids, is membrane-bound, locates in Cell membrane.

Transporter for the divalent cation Zn(2+), Mediates the influx of Zn(2+) into cells from extracellular space

Belongs to the ZIP transporter (TC 2,A,5) family


This is Potassium channel toxin gamma-KTx 2.2 protein, from Manchurian scorpion, contains 57 amino acids, is soluble, locates in Extracellular.

Blocks human and/or rat Kv11,1/KCNH2/ERG1, Kv11,2/KCNH6/ERG2 and Kv11,3/KCNH7/ERG3 by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry (By similarity), Has also a minimal effect on rat ELK1/KCNH4 potassium channels (By similarity), Has been shown to weakly inhibit Kv11,1/KCNH2/ERG1, Kv1,1/KCNA1, Kv1,2/KCNA2 and Kv1,3/KCNA3 voltage-gated potassium channels (PubMed:29483648)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Gamma-KTx 2 subfamily


This is Toxin To3 protein, from Amazonian scorpion, contains 86 amino acids, is soluble, locates in Extracellular.

Affects sodium-permeability in pituitary GH3 cells in culture, Inhibits the inactivation of sodium activated channels (Nav), Slightly delays the activation time course, and consequently the time to peak, Shifts the voltage dependence of the activation to more negative potentials, Does not reduce the peak sodium-current amplitude

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Beta-toxin To4 protein, from Amazonian scorpion, contains 86 amino acids, is soluble, locates in Extracellular.

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing, This toxin shows moderate inhibition of Nav1,1/SCN1A, Nav1,2/SCN2A, and Nav1,4/SCN4A, and promotes a left voltage shift on these channels, It exhibits similar potency on Nav1,2/SCN2A and Nav1,4/SCN4A (40-50% peak current inhibition at 0,5 uM), and weaker inhibition on Nav1,2 (20-30% peak current inhibition at 0,5 uM)


This is Alpha-bungarotoxin isoform V31 protein, from Many-banded krait, contains 95 amino acids, is soluble, locates in Extracellular.

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission

Belongs to the snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily


This is Complement C1q tumor necrosis factor-related protein 8 protein, from Human, contains 252 amino acids, is soluble, locates in Extracellular.


This is Alpha-endosulfine protein, from Rat, contains 121 amino acids, is soluble, locates in Cytoplasm.

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis, When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase, Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity)


This is Osteocrin protein, from Rat, contains 132 amino acids, is soluble, locates in Extracellular.

Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle, Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production, Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C, May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle


This is Osteocrin protein, from Human, contains 133 amino acids, is soluble, locates in Extracellular.

Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience (PubMed:27830782), Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex (PubMed:27830782), Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity)


This is Kappa-theraphotoxin-Gr2c protein, from Chilean rose tarantula, contains 81 amino acids, is soluble, locates in Extracellular.

Inhibits sodium channels Nav1,1/SCN1A (IC(50)=5,7 uM), Nav1,2/SCN2A (IC(50)=12 uM), Nav1,4/SCN4A (IC(50)=4 uM), Nav1,6/SCN8A (IC(50)=6,6 uM), Nav1,7/SCN9A (IC(50)=13,6-1030 nM), potassium channels Kv11,1/KCNH2 (IC(50)=4,7 uM), as well as high-voltage-gated calcium channels Cav1,2/CACNA1C (IC(50)= nM) (PubMed:19955179, PubMed:30661758, PubMed:31234412), Also blocks mechanosensitive ion channels (also named stretch-activated channels or SACs) and the hypotonic cell swelling induced calcium increase associated with the activation of such channels (Ref,3), It can thus be useful in treating cardiac ventricular disturbances (Ref,3), Also induces analgesia in mammals (Ref,2)

Belongs to the neurotoxin 30 (phrixotoxin) family


This is Histone H4 protein, from Maize, contains 103 amino acids, locates in Nucleus.

Core component of nucleosome, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling


This is Mitochondrial pyruvate carrier 1 protein, from Mouse, contains 109 amino acids, is membrane-bound, locates in Mitochondrion.

Mediates the uptake of pyruvate into mitochondria

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2,A,105) family


This is Sulfotransferase 4A1 protein, from Rat, contains 284 amino acids, is soluble, locates in Cytoplasm.

Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol, May have a role in the metabolism of drugs and neurotransmitters in the CNS (By similarity)

Belongs to the sulfotransferase 1 family


This is Fibroblast growth factor 17 protein, from Rat, contains 216 amino acids, is soluble, locates in Extracellular.

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain, Required for normal brain development

Belongs to the heparin-binding growth factors family


This is Selenoprotein W protein, from Rat, contains 88 amino acids, is soluble, locates in Cytoplasm.

Plays a role as a glutathione (GSH)-dependent antioxidant, May be involved in a redox-related process, May play a role in the myopathies of selenium deficiency

Belongs to the SelWTH family, Selenoprotein W subfamily


This is DNA-directed RNA polymerase 3, chloroplastic protein, from Wood tobacco, contains 977 amino acids, locates in Plastid.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Belongs to the phage and mitochondrial RNA polymerase family


This is Histone H3.2 protein, from Maize, contains 136 amino acids, locates in Nucleus.


This is Kinetoplastid membrane protein 11 protein, from Trypanosoma brucei brucei, contains 92 amino acids, is soluble, locates in Cytoplasm.

May be involved in the regulation of the cytoskeleton through interaction with the subpellicular microtubules, May be involved in parasite mobility and attachment to the surface of the host cell, Behaves as a strong immunogen during infection (By similarity)


This is Potassium channel toxin AaTXK-beta protein, from Sahara scorpion, contains 91 amino acids, is soluble, locates in Extracellular.

Peptide activator of Kv7,4/KCNQ4 channels, Also acts as a subtype-selective activator of channels formed by Kv7,3 (KCNQ3), Kv7,2/Kv7,3 (KCNQ2/KCNQ3), Kv7,5/Kv7,3 (KCNQ3/KCNQ5) subunits

Belongs to the long chain scorpion toxin family, Class 1 subfamily


This is Potassium channel toxin TsTXK-beta protein, from Brazilian scorpion, contains 87 amino acids, is soluble, locates in Extracellular.

Specifically blocks voltage-gated potassium channels Kv4,2/KCND2, When measured at the peak current, the blocking effect of this toxin is about 65% and shows an IC(50)=652 nM (PubMed:27346450), However, when measured at a later moment of the depolarising test pulse (500 ms), a 100% block of the current is observed with an IC(50)=313 nM (PubMed:27346450), This may indicate a preference of the toxin for binding the inactivated state of the channel, The inhibition is completely reversible (PubMed:27346450), Using intraplantar injections on rat, this toxin induces overt nociception (licking and lifting behaviors) and decreases the mechanical nociceptive threshold (hyperalgesia), Furthermore, the hyperalgesia is prolonged when intrathecal injections are performed (PubMed:27346450)


This is Zinc fingers and homeoboxes protein 1 protein, from Mouse, contains 873 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Acts as a transcriptional repressor, Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA, May link molecule between DNMT3B and other co-repressor proteins (By similarity)


This is 5'-AMP-activated protein kinase subunit beta protein, from Fission yeast, contains 298 amino acids, is soluble, locates in Cytoplasm.

Beta subunit of AMP-activated protein kinase (AMPK), which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation, Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source-regulated subcellular location and substrate specificity of the AMPK kinase complex

Belongs to the 5'-AMP-activated protein kinase beta subunit family


This is Extracellular ribonuclease LE protein, from Tomato, contains 230 amino acids, is soluble, locates in Extracellular.

Probably involved in plant phosphate-starvation rescue system


This is 5-formyltetrahydrofolate cyclo-ligase protein, from Rabbit, contains 201 amino acids, is soluble, locates in Cytoplasm.

Contributes to tetrahydrofolate metabolism, Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids, Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate, It can also use 5-formyltetrahydropteroic acid (5-CHO-H(4)Pte) and 5-formyltetrahydropteroylhistidine (5-CHO-H(4)PteHis) as substrate

Belongs to the 5-formyltetrahydrofolate cyclo-ligase family


This is Apolipophorin-3 protein, from Greater wax moth, contains 186 amino acids, is soluble, locates in Extracellular.

Assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein, It increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake, It thus plays a critical role in the transport of lipids during flight in several species of insects, Has antibacterial activity against the Gram-positive bacteria L,monocytogenes (MIC=6,5 uM), Lacks antibacterial activity against the Gram-positive bacteria B,circulans, M,luteus, S,aureus, and S,lutea, and the Gram-negative bacteria E,coli D31, E,coli ATCC 25922, and S,typhimurium, Lacks antifungal activity against S,cerevisiae, P,pastoris, Z,marxianus, C,albicans, C,wickerhamii, A,niger, F,oxysporum, and T,harizianum

Belongs to the insect apolipophorin-3 family


This is Big defensin protein, from Japanese horseshoe crab, contains 117 amino acids, is soluble, locates in Extracellular.

Significantly inhibits the growth of Gram-negative and Gram-positive bacteria and fungi in vitro


This is Macrophage migration inhibitory factor homolog protein, from Trichina worm, contains 114 amino acids, is soluble, locates in Extracellular.

Tautomerization of the methyl ester of L-dopachrome, Inhibits migration of human peripheral blood mononuclear cells


This is Defensin-B protein, from Yellowfever mosquito, contains 98 amino acids, is soluble, locates in Extracellular.

Antibacterial peptide mostly active against Gram-positive bacteria

Belongs to the invertebrate defensin family, Type 1 subfamily


This is Defensin-C protein, from Yellowfever mosquito, contains 99 amino acids, is soluble, locates in Extracellular.


This is Lepidopteran-selective toxin protein, from Eastern Indian scorpion, contains 62 amino acids, is soluble, locates in Extracellular.

Toxin with unknown function in healthy organisms, On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells, This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity), Induces flaccid paralysis in H,virescens larvae, Is not toxic to S,falculata larvae or mice

Belongs to the short scorpion toxin superfamily, Chloride channel inhibitor family


This is Nucleoside diphosphate kinase 3 protein, from Spinach, contains 153 amino acids, locates in Plastid.

Major role in the synthesis of nucleoside triphosphates other than ATP, The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate, Shows the highest specificity towards GDP


This is Candoxin protein, from Malayan krait, contains 87 amino acids, is soluble, locates in Extracellular.

Binds and inhibits muscular and neuronal nicotinic acetylcholine receptors (nAChR), Is a reversible antagonist of muscle nAChR (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) (IC(50)=10 nM) and a potent and poorly reversible antagonist of the neuronal alpha-7/CHRNA7 nAChR (IC(50)=50 nM), May exhibit differential affinities for the two binding sites on the muscle nAChR

Belongs to the snake three-finger toxin family, Ancestral subfamily, Orphan group IV sub-subfamily


This is Omega-ctenitoxin-Pn3a protein, from Brazilian armed spider, contains 116 amino acids, is soluble, locates in Extracellular.

This toxin is a potent and practically irreversible antagonist of both Cav2,1/CACNA1A and Cav2,2/CACNA1B calcium channels, while it displays a partial and rapidly reversible block of Cav2,3/CACNA1E calcium channels and no effect on Cav3/CACNA1 calcium channels, Inhibits glutamate uptake from rat brain synaptosomes by an interaction between cysteines from both glutamate transporter and toxin, Blocks potassium-induced exocytosis of synaptic vesicles in brain cortical synaptosomes with an IC(50) of 1,1 nM, In mice, induces rapid general flaccid paralysis followed by death in 10-30 minutes at dose levels of 5 ug per mouse, In rat brain, inhibits glutamate release, neuronal death and loss of neurotransmission in the hippocampus resulting from ischemia

Belongs to the neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily


This is Omega-ctenitoxin-Pn4a protein, from Brazilian armed spider, contains 90 amino acids, is soluble, locates in Extracellular.

Potent blocker of nociceptor cation channels TRPA1 and high voltage-activated calcium channels (PubMed:12470700, PubMed:15933156, PubMed:27759880), It acts mainly on P/Q-type (Cav2,1/CACNA1A) calcium channels and has a minor effect on L- (Cav1/CACNA1) and N-type (Cav2,2/CACNA1B) calcium channels (PubMed:12470700, PubMed:15933156), Blocks glutamate release in synaptic transmission mediated by calcium channels (PubMed:12470700), The toxin also inhibits the KCl-induced increase of intrasynaptosomal free calcium (PubMed:12470700), It also shows antiproliferative effects on different glioma cell lines (M059J, U-138MG and U-251MG) (PubMed:28202361), In vivo, it shows analgesic effects in rodent models of pain (PubMed:18774645), In addition, it selectively blocks nocifensive responses evoked by reactive TRPA1 channel agonist (PubMed:27759880), Furthermore, it also reduces the TRPA1 channel-dependent hyperalgesia in a model of neuropathic pain induced by the chemotherapeutic agent BTZ (PubMed:27759880), In addition, it causes reduction of tumor area in the mouse glioma model, that is induced by the orthotopic injection of GL261 cells into the brain (PubMed:28202361)

Belongs to the neurotoxin 09 (Tx3-6) family


This is Cholinesterase protein, from Horse, contains 574 amino acids, is soluble, locates in Extracellular.

Esterase with broad substrate specificity, Contributes to the inactivation of the neurotransmitter acetylcholine, Can degrade neurotoxic organophosphate esters (By similarity)

Belongs to the type-B carboxylesterase/lipase family


This is DnaJ homolog subfamily B member 11 protein, from Dog, contains 358 amino acids, is soluble, locates in Endoplasmic reticulum.

As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins, Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed, May help recruiting HSPA5 and other chaperones to the substrate, Stimulates HSPA5 ATPase activity, It is necessary for maturation and correct trafficking of PKD1


This is Defensin-like peptide 2/4 protein, from Duckbill platypus, contains 66 amino acids, is soluble, locates in Extracellular.

Does not show antimicrobial, myotoxic, hemolytic and cell-promoting activities


This is Small ribosomal subunit protein uS13c protein, from Spinach, contains 172 amino acids, locates in Plastid.

Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus

Belongs to the universal ribosomal protein uS13 family


This is Small ribosomal subunit protein cS22 protein, from Spinach, contains 260 amino acids, locates in Plastid.

Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus (PubMed:10874039, PubMed:28007896), cS22 may have a role in the recruitment of stored chloroplast mRNAs for active protein synthesis (PubMed:12605670)

Belongs to the chloroplast-specific ribosomal protein cS22 family


This is Fatty acid-binding protein, liver protein, from South American lungfish, contains 125 amino acids, is soluble, locates in Cytoplasm.

Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm, May be involved in intracellular lipid transport, Binds one trans-parinaric acid molecule or two cis-parinaric acid molecules, Affinity for mono- and polyunsaturated fatty acids is higher than that for saturated ones, Affinity for fatty acid coenzyme A derivatives, lysophosphatidic acid, lysophospholipds, retinoids, bilirubin and bile salts is similar to or higher than that for fatty acids, Affinity for prostaglandins, peroxisomal proliferators, bezafibrate and clofibrate is moderate to low

Belongs to the calycin superfamily, Fatty-acid binding protein (FABP) family


This is Snake venom vascular endothelial growth factor toxin ICPP protein, from Levantine viper, contains 110 amino acids, is soluble, locates in Extracellular.

Snake venom VEGFs may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension, This protein increases vascular permeability and angiogenesis probably through VEGF receptor (KDR/VEGFR-2) signaling (PubMed:12021274), Induces DNA synthesis in human umbilical vein endothelial cells, and promotes mouse embryonic stem cell proliferation and differentiation (PubMed:12021274), It may also induce a drastic hypotensive effect after intravenous injection (By similarity), The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase (By similarity)

Belongs to the PDGF/VEGF growth factor family, Snake venom VEGF subfamily


This is Alpha-elapitoxin-Oh2b protein, from King cobra, contains 91 amino acids, is soluble, locates in Extracellular.

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (By similarity), Recombinant LNTX1 leads to a functional block of the muscle-type acetylcholine receptors, Has a cytotoxic activity, This neurotoxin is lethal (PubMed:16689684)

Belongs to the snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily


This is Small ribosomal subunit protein uS11m protein, from Bovine, contains 197 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS11 family


This is Small ribosomal subunit protein uS15m protein, from Human, contains 257 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS15 family


This is Small ribosomal subunit protein mS40 protein, from Bovine, contains 258 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bS18 family, Mitochondrion-specific ribosomal protein mS40 subfamily


This is Small ribosomal subunit protein mS29 protein, from Bovine, contains 397 amino acids, locates in Mitochondrion.

Involved in mediating interferon-gamma-induced cell death

Belongs to the mitochondrion-specific ribosomal protein mS29 family


This is U1-theraphotoxin-Hs1a protein, from Chinese bird spider, contains 85 amino acids, is soluble, locates in Extracellular.

Lethal neurotoxin that blocks neuromuscular transmission, Acts cooperatively to potentiate the activity of huwentoxin-I, This toxin is active against insects

Belongs to the neurotoxin 12 (Hwtx-2) family, 02 (Hwtx-2) subfamily


This is High mobility group nucleosome-binding domain-containing protein 5 protein, from Human, contains 282 amino acids, locates in Nucleus.

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction


This is Phospholipase A2 protein, from Buff-tailed bumblebee, contains 136 amino acids, is soluble, locates in Extracellular.

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is Kininogen-1 protein, from Yellow-bellied toad, contains 97 amino acids, is soluble, locates in Extracellular.

[Ala3,Thr6]bradykinin: produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle, Possesses insulin-releasing activity, May target bradykinin receptors (BDKRB)

Belongs to the bradykinin-related peptide family


This is Maximins 2/H1 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.

Maximin-H1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria, It shows also antimicrobial activity against the fungus C,albicans, Shows strong hemolytic activity


This is Maximins 4/H3 type 1 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.

Maximin-H3 shows antibacterial activity against both Gram-positive and Gram-negative bacteria, It shows also antimicrobial activity against the fungus C,albicans, Shows strong hemolytic activity


This is Maximins 5/H4 type 1 protein, from Giant fire-bellied toad, contains 145 amino acids, is soluble, locates in Extracellular.

Maximin-H4 shows antibacterial activity against both Gram-positive and Gram-negative bacteria, It shows also antimicrobial activity against the fungus C,albicans, Shows strong hemolytic activity


This is Sperm protamine P1 protein, from Purple dye murex, contains 107 amino acids, locates in Nucleus.

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis, They compact sperm DNA into a highly condensed, stable and inactive complex


This is Natriuretic peptide TNP-b protein, from Australian taipan, contains 111 amino acids, is soluble, locates in Extracellular.

Exhibits vasoactive (PubMed:15652496) and hypotensive activity (By similarity), Is only weakly active on natriuretic peptide receptor-C (NPR3)

Belongs to the natriuretic peptide family


This is Sperm protamine R3 isoform 1 protein, from Spotted ratfish, contains 48 amino acids, locates in Nucleus.


This is Sperm protamine R3 isoform 2 protein, from Spotted ratfish, contains 48 amino acids, locates in Nucleus.


This is Carbonic anhydrase 1 protein, from Antarctic teleost icefish, contains 259 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the reversible hydration of carbon dioxide

Belongs to the alpha-carbonic anhydrase family


This is Neurotoxin BtITx3 protein, from Eastern Indian scorpion, contains 60 amino acids, is soluble, locates in Extracellular.

Toxin with unknown function in healthy organisms, On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells, This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity), Has been shown to weakly inhibit Kv1,1/KCNA1, Kv1,2/KCNA2 and Kv1,3/KCNA3 voltage-gated potassium channels (PubMed:29483648), In vivo, induces contraction, severe paralysis and death in insect larva of Helicoverpa armigera (PubMed:12297317)

Belongs to the short scorpion toxin superfamily, Chloride channel inhibitor family


This is Defensin protein, from Sandfly, contains 98 amino acids, is soluble, locates in Extracellular.

Has antiparasitic activity against promastigote forms of L,major, and antibacterial activity against Gram-positive bacterium S,aureus, Has antifungal activity against the yeasts C,albicans and S,cerevisiae, but not C,glabrata, Has antifungal activity against filamentous fungi A,fumigatus, F,culmorum, F,oxysporum, N,crassa, T,viride and T,mentagrophytes, but not B,bassiana

Belongs to the invertebrate defensin family, Type 1 subfamily


This is Disintegrin obtustatin protein, from Levant blunt-nosed viper, contains 41 amino acids, is soluble, locates in Extracellular.

Is a potent and selective inhibitor of alpha-1/beta-1 (ITGA1/ITGB1) integrin, It blocks the adhesion of alpha-1/beta-1-expressing K562 cells to immobilized collagens IV and I with IC(50) of 2 and 0,5 nM, respectively, Potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half, Is 25-fold less potent than viperistatin

Belongs to the disintegrin family, Short disintegrin subfamily


This is ATP synthase subunit beta-1, mitochondrial protein, from Mouse-ear cress, contains 556 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain, F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk, During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation, Subunits alpha and beta form the catalytic core in F(1), Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Belongs to the ATPase alpha/beta chains family


This is Mu-hexatoxin-Mg1a protein, from Japanese funnel web spider, contains 121 amino acids, is soluble, locates in Extracellular.

Insecticidal neurotoxin, Shows competition for site 3 of insect voltage-gated sodium channels (Nav), Induces flaccid paralysis when injected into lepidopteran larvae, Is not toxic to mice when injected intracranially at 20 pmol/g

Belongs to the neurotoxin 14 (magi-1) family, 09 (magi-1) subfamily


This is Delta-hexatoxin-Mg1a protein, from Japanese funnel web spider, contains 105 amino acids, is soluble, locates in Extracellular.

Selectively slows channel inactivation of mammalian Nav1,1/SCN1A, Nav1,3/SCN3A, and Nav1,6/SCN8A and shows higher affinity for insect Nav1/para channels (site 3), Induces tonic repetitive firing of nerve impulses in insect neurons accompanied by plateau potentials

Belongs to the neurotoxin 06 (delta-actx) family


This is Proteinase inhibitor PSKP-1 protein, from Sauvage's leaf frog, contains 58 amino acids, is soluble, locates in Extracellular.

Has antibacterial activity against Gram-negative bacterium E,coli ATCC 11229, Shows hemagglutinating activity, Inhibits prolyl endopeptidase, but not trypsin, chymotrypsin, V8 protease and proteinase K, May have a role in mucosal defense against microbes by interacting directly with their membranes


This is Omega-hexatoxin-Ar1a protein, from Sydney funnel-web spider, contains 85 amino acids, is soluble, locates in Extracellular.

Insecticidal toxin that reversibly and voltage-independently blocks both mid-low- (M-LVA) and high-voltage-activated (HVA) calcium channels (Cav) in cockroach DUM neurons, Also causes a modest block of insect sodium channel currents (Nav), Induces potent excitatory symptoms, followed by flaccid paralysis leading to death in house crickets

Belongs to the neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily


This is Putative NADPH-dependent methylglyoxal reductase GRP2 protein, from Yeast, contains 341 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde, MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation

Belongs to the NAD(P)-dependent epimerase/dehydratase family, Dihydroflavonol-4-reductase subfamily


This is Pyruvate decarboxylase protein, from Yeast, contains 567 amino acids, is soluble, locates in Cytoplasm.


This is Glucose-6-phosphate isomerase protein, from Yeast, contains 550 amino acids, is soluble, locates in Cytoplasm.

In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis


This is Snake venom vascular endothelial growth factor toxin HF protein, from Aspic viper, contains 110 amino acids, is soluble, locates in Extracellular.

Snake venom VEGFs that may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension, This protein induces an increase in capillary permeability after intradermal injection, as well as a drastic hypotensive effect after intravenous injection (PubMed:10512636), The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase (PubMed:14600159), Also induces angiogenesis in vitro, probably through VEGF receptor (KDR/VEGFR-2) signaling (PubMed:14600159)

Belongs to the PDGF/VEGF growth factor family, Snake venom VEGF subfamily


This is Pectinesterase 3 protein, from Sweet orange, contains 584 amino acids, is soluble, locates in Extracellular.

Acts in the modification of cell walls via demethylesterification of cell wall pectin

In the C-terminal section; belongs to the pectinesterase family


This is Cytochrome c-2 protein, from Fruit fly, contains 108 amino acids, is soluble, locates in Mitochondrion.

Electron carrier protein, The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase, Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain