This is Alpha-fibrinogenase shedaoenase protein, from Shedao island pit viper, contains 238 amino acids, is soluble, locates in Extracellular.

Snake venom protease that shows fibrinogenolytic activities, Preferentially degrades the alpha-chain of human fibrinogen (FGA) and slowly degrades the beta-chain (FGB), Has no effect on the gamma-chain, Can hydrolyze fibrinogen without forming fibrin clots and also can degrade fibrin, Hydrolyzes the substrate of plasmin more potently than the substrate of thrombin, Shows a preferential cleavage at Lys-|-Xaa instead of Arg-|-Xaa bonds

Belongs to the peptidase S1 family, Snake venom subfamily


This is Disintegrin gabonin-1 protein, from Gaboon adder, contains 128 amino acids, is soluble, locates in Extracellular.

The heterodimer bitisgabonin-1 is a potent inhibitor of the adhesion of the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin

Belongs to the disintegrin family, Dimeric disintegrin subfamily


This is Progestin and adipoQ receptor family member 3 protein, from Mouse, contains 311 amino acids, is membrane-bound, locates in Golgi apparatus.

Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi


This is Flagellar radial spoke protein 2 protein, from Chlamydomonas smithii, contains 738 amino acids, is soluble, locates in Cytoplasm.

Flagellar radial spokes contribute to the regulation of dynein arm activity and thus the pattern of flagellar bending, They consist of a thin stalk, which is attached to the a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules (PubMed:16507594), Binds calmodulin in a calcium-dependent manner (PubMed:14871938)


This is Zinc finger protein 503 protein, from Zebrafish, contains 563 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Required for segmental gene expression during hindbrain development, May function as a transcriptional repressor


This is Choline dehydrogenase, mitochondrial protein, from Rat, contains 599 amino acids, is membrane-bound, locates in Mitochondrion.

Belongs to the GMC oxidoreductase family


This is Insulin growth factor-like family member 1 protein, from Human, contains 110 amino acids, is soluble, locates in Extracellular.

Probable ligand of the IGFLR1 cell membrane receptor


This is UPF0764 protein C16orf89 protein, from Human, contains 402 amino acids, is soluble, locates in Extracellular.


This is Radial spoke head 1 homolog protein, from Common carp, contains 218 amino acids, is soluble, locates in Cytoplasm.

Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia


This is WRKY transcription factor SUSIBA2 protein, from Barley, contains 573 amino acids, locates in Nucleus.

Transcription factor involved in starch synthesis (PubMed:12953112), Acts as a transcriptional activator in sugar signaling (PubMed:16167901), Interacts specifically with the SURE and W-box elements, but not with the SP8a element (PubMed:12953112)


This is Isoflavone 2'-hydroxylase protein, from Barrel medic, contains 498 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the biosynthesis of the pterocarpin phytoalexins, Acts on isoflavones with a 4'-methoxy group on the B-ring, such as formononetin and biochanin A, and on pseudobaptigenin, Has a low activity with daidzein and genistein and no activity with the 7-O-methylated isoflavonoids isoformononetin and prunetin


This is BTB/POZ domain-containing protein KCTD12 protein, from Mouse, contains 327 amino acids, is membrane-bound, locates in Cell membrane.

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response, Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization


This is Histone H3-like centromeric protein A protein, from Chicken, contains 131 amino acids, locates in Nucleus.

Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:14563550), Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore, The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3, May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity), Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:15870271)


This is B3 domain-containing protein IDEF1 protein, from Rice, contains 362 amino acids, locates in Nucleus.

Transcription regulator involved in iron deficiency response and tolerance, May regulate directly iron transporters or other transcription factors involved in iron-deficiency response, Binds specifically to the DNA sequence 5'-CATGC-3' of the IDE1 element found in the promoter of the barley iron deficiency-inducible gene IDS2


This is Aquaporin NIP2-1 protein, from Rice, contains 298 amino acids, is membrane-bound, locates in Cell membrane.

Silicon influx transporter responsible for silicon transport from the external solution to the root cells (PubMed:16572174), Is coupled with the silicon efflux transporter LSI2 in both exodermal and endodermal root cells for an efficient silicon transport across the cells into the stele (PubMed:17625566), Silicon is beneficial to plant growth and helps plants to overcome abiotic and biotic stresses by preventing lodging (falling over) and increasing resistance to pests and diseases, as well as other stresses (PubMed:16572174), Is coupled with LSI2 transporter in roots for efficient uptake of arsenite, which is further dispatched in shoots and grains (PubMed:18626020), Mediates uptake of methylated arsenic species in roots (PubMed:19542298)

Belongs to the MIP/aquaporin (TC 1,A,8) family, NIP (TC 1,A,8,12) subfamily


This is Soluble starch synthase 2-2, chloroplastic/amyloplastic protein, from Rice, contains 694 amino acids, locates in Plastid.

May contribute to the deposition of transient starch in chloroplasts of leaves

Belongs to the glycosyltransferase 1 family, Bacterial/plant glycogen synthase subfamily


This is Isocitrate lyase protein, from Rice, contains 572 amino acids, locates in Peroxisome.

Involved in storage lipid mobilization during the growth of higher plant seedling

Belongs to the isocitrate lyase/PEP mutase superfamily, Isocitrate lyase family


This is Metal transporter NRAT1 protein, from Rice, contains 545 amino acids, is membrane-bound, locates in Cell membrane.

Metal transporter that transports the trivalent cation aluminum (Al(3+)), but does not seem to transport divalent cations such as iron (Fe(2+)), manganese (Mg(2+)) or Cadmium (Cd(2+)), Involved in Al tolerance by taking up Al in root cells, where it is detoxified by chelation with organic acid anions and sequestration into the vacuoles


This is S-(+)-linalool synthase, chloroplastic protein, from Rice, contains 595 amino acids, locates in Plastid.

Involved in monoterpene (C10) biosynthesis, The major product is S-(+)-linalool, Linalool production is induced by jasmonate in response to pathogen attack, it possesses antibacterial activity and is important for resistance to the bacterial blight pathogen Xanthomonas oryzae pv, oryzae (Xoo), Plants over-expressing linalool synthase display enhanced resistance to Xoo

Belongs to the terpene synthase family, Tpsb subfamily


This is L-lactate dehydrogenase A-like 6A protein, from Human, contains 332 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the interconversion of L-lactate and pyruvate with nicotinamide adenine dinucleotide NAD(+) as a coenzyme (PubMed:18351441), Significantly increases the transcriptional activity of JUN, when overexpressed

Belongs to the LDH/MDH superfamily, LDH family


This is F-box only protein 50 protein, from Human, contains 275 amino acids, is soluble, locates in Cytoplasm.


This is Tripeptidyl-peptidase sed3 protein, from Neosartorya fumigata, contains 596 amino acids, is soluble, locates in Extracellular.

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence


This is Nucleosome assembly protein 1;1 protein, from Common tobacco, contains 374 amino acids, locates in Cytoplasm.

May modulate chromatin structure by regulation of nucleosome assembly/disassembly, Could function together with B-type cyclins in the regulation of microtubule dynamics

Belongs to the nucleosome assembly protein (NAP) family


This is Chaperone protein ClpB2, chloroplastic protein, from Rice, contains 978 amino acids, locates in Plastid.

Molecular chaperone that may play a role in chloroplast development


This is Fe(2+) transport protein 1 protein, from Rice, contains 374 amino acids, is membrane-bound, locates in Cell membrane.

Iron transporter involved in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer, May also transport other divalent cations

Belongs to the ZIP transporter (TC 2,A,5) family


This is Calcineurin B-like protein 4 protein, from Rice, contains 210 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a calcium sensor involved in the regulatory pathway for the control of intracellular Na(+) and K(+) homeostasis and salt tolerance, Operates in synergy with CIPK24 to activate the plasma membrane Na(+)/H(+) antiporter SOS1, May function as positive regulator of salt stress responses, CBL proteins interact with CIPK serine-threonine protein kinases, Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner

Belongs to the calcineurin regulatory subunit family


This is Protein PAIR1 protein, from Rice, contains 492 amino acids, locates in Nucleus.

Involved in spore formation, Plays an essential role in the establishment of homologous chromosome pairing in early meiosis


This is Pyroglutamyl-peptidase 1 protein, from Rat, contains 209 amino acids, is soluble, locates in Cytoplasm.

Removes 5-oxoproline from various penultimate amino acid residues except L-proline


This is TOX high mobility group box family member 2 protein, from Rat, contains 473 amino acids, locates in Nucleus.

Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system


This is Aluminum-activated malate transporter 1 protein, from Wheat, contains 459 amino acids, is membrane-bound, locates in Cell membrane.

Malate transporter critical for aluminum tolerance, Permeable to chloride, nitrate, sulfate and malate

Belongs to the aromatic acid exporter (TC 2,A,85) family


This is ESF1 homolog protein, from Rat, contains 842 amino acids, is soluble, locates in Nucleus.

May constitute a novel regulatory system for basal transcription, Negatively regulates ABT1


This is E3 ubiquitin-protein ligase hel2 protein, from Fission yeast, contains 732 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains, Activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs, Acts as a ribosome collision sensor: specifically recognizes and binds collided ribosome and ubiquitinates the 40S ribosomal proteins rps20/uS10 and rps3/uS3, Catalyzes 'Lys-63'-linked polyubiquitination of rps20/uS10, promoting recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides


This is Homeodomain-only protein protein, from Rat, contains 73 amino acids, locates in Nucleus.

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development, Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development, Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF, Overexpression causes cardiac hypertrophy, Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding


This is Heterogeneous nuclear ribonucleoprotein F protein, from Rat, contains 415 amino acids, is soluble, locates in Nucleus.

Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm, Plays a role in the regulation of alternative splicing events, Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity)


This is Synaptonemal complex protein ZEP1 protein, from Rice, contains 869 amino acids, locates in Nucleus.

Required for chromosome synapsis and regulates crossover frequency during meiosis, Acts as transverse filament protein and constitutes the central element of the synaptonemal complex


This is Fimbrin-1 protein, from Mouse-ear cress, contains 687 amino acids, is soluble, locates in Cytoplasm.

Cross-links actin filaments (F-actin) in a calcium independent manner, Induces the formation of actin aggregates, Stabilizes and prevents F-actin depolymerization mediated by profilin, Key regulator of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus


This is Ribonuclease DdI protein, from Social amoeba, contains 223 amino acids, locates in Lysosome/Vacuole.

Releases mononucleotides from RNA in the order of 3'-GMP > 3'-UMP > 3'-AMP > 3'-CMP


This is Facilitated trehalose transporter Tret1 protein, from African malaria mosquito, contains 793 amino acids, is membrane-bound, locates in Cell membrane.

High-capacity facilitative transporter for trehalose, Does not transport maltose, sucrose or lactose, Mediates the bidirectional transfer of trehalose, Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Trehalose transporter subfamily


This is Zinc finger protein 367 protein, from Human, contains 350 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional activator, Isoform 1 may be involved in transcriptional activation of erythroid genes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Erabutoxin c protein, from Black-banded sea krait, contains 83 amino acids, is soluble, locates in Extracellular.

Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission, Binds to Torpedo marmorata nAChR (Kd=0,14 nM) (PubMed:7721859)

Belongs to the snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily


This is Bone morphogenetic protein 3 protein, from African clawed frog, contains 458 amino acids, is soluble, locates in Extracellular.

Dorsalizing factor, Antagonizes mesoderm formation by ventralizing BMPs


This is Alpha-bungarotoxin, isoform A31 protein, from Malayan krait, contains 95 amino acids, is soluble, locates in Extracellular.

Binds with high affinity to muscular (tested on Torpedo marmorata, Kd=0,4 nM) and neuronal (tested on chimeric alpha-7/CHRNA7, Kd=0,95 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission, It also shows an activity on GABA(A) receptors, It antagonises GABA-activated currents with high potency when tested on primary hippocampal neurons, It inhibits recombinantly expressed GABA(A) receptors composed of alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits with high potency (62,3% inhibition at 20 uM of toxin), It also shows a weaker inhibition on GABA(A) receptors composed of alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits, alpha-4-beta-2-gamma-2 (GABRA4-GABRB2-GABRG2) subunits, and alpha-5-beta-2-gamma-2 (GABRA5-GABRB2-GABRG2) subunits, A very weak inhibition is also observed on GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2), It has also been shown to bind and inhibit recombinant GABA(A) receptor beta-3/GABRB3 subunit (Kd=about 50 nM), In addition, it blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4,2 uM), In vivo, when intraperitoneally injected into mice, induces flaccid paralysis of the limbs and respiratory distress, and causes death in a dose-dependent manner (PubMed:14505938)

Belongs to the snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily


This is Zygote arrest protein 1.S protein, from African clawed frog, contains 295 amino acids, has 1 3CxxC-type Zinc finger, is soluble, locates in Cytoplasm.

mRNA-binding protein required for maternal mRNA storage, translation and degradation during oocyte maturation (PubMed:23827238), Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (By similarity), Binds to the 3'-UTR of maternal mRNAs in immature oocytes, inhibiting their translation (PubMed:23827238)


This is Probable D-lactate dehydrogenase, mitochondrial protein, from Mouse, contains 484 amino acids, locates in Mitochondrion.

Involved in D-lactate, but not L-lactate catabolic process

Belongs to the FAD-binding oxidoreductase/transferase type 4 family


This is Podocan protein, from Mouse, contains 611 amino acids, is soluble, locates in Extracellular.

Negatively regulates cell proliferation and cell migration, especially in smooth muscle cells

Belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class V subfamily


This is Cytoskeleton-associated protein 2-like protein, from Mouse, contains 745 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells


This is Phosphoinositide phosphatase SAC6 protein, from Mouse-ear cress, contains 593 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P, Involved in priming for different defense responses


This is Endoplasmic reticulum oxidoreductin-2 protein, from Mouse-ear cress, contains 472 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds, Acts by oxidizing directly PDI isomerase through a direct disulfide exchange, Does not act as a direct oxidant of folding substrate, but relies on PDI to transfer oxidizing equivalent, Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI and related proteins, Its reoxidation probably involves electron transfer to molecular oxygen via FAD, Acts independently of glutathione, May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity)


This is Folate transporter 1, chloroplastic protein, from Mouse-ear cress, contains 308 amino acids, is membrane-bound, locates in Plastid.

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is (S)-coclaurine N-methyltransferase protein, from Opium poppy, contains 351 amino acids, is soluble, locates in Cytoplasm.

Involved in the biosynthesis of benzylisoquinoline alkaloids, N-methyltransferase methylating (S)-coclaurine, 4'-O-methylcoclaurine and norlaudanine can also be used as substrates


This is Urea-proton symporter DUR3 protein, from Rice, contains 721 amino acids, is membrane-bound, locates in Cell membrane.

High-affinity urea-proton symporter involved in the active transport of urea across the plasma membrane into root cells, May play an important role in urea uptake by plant cells at low external urea concentrations

Belongs to the sodium:solute symporter (SSF) (TC 2,A,21) family


This is Signal peptidase complex-like protein DTM1 protein, from Rice, contains 112 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Functions in tapetum development during early meiosis, May play a role in the endoplasmic reticulum (ER) membrane in the early stages of tapetum development in anthers, Seems to function after MSP1 and before UDT1


This is Squamosa promoter-binding-like protein 8 protein, from Rice, contains 416 amino acids, has 1 SBP-type Zinc finger, locates in Nucleus.

SBP-type

Probable transcription factor that plays an important role in building the laminar joint between leaf blade and leaf sheath boundary, thereby controlling ligule and auricle development


This is Monoterpene synthase FDS-5, chloroplastic protein, from Spiked big sagebrush, contains 394 amino acids, locates in Plastid.

Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP), CPP is a precursor of the pyrethrin insecticides, When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP


This is Dermonecrotic toxin LarSicTox-alphaIB2a protein, from Arizona brown spider, contains 320 amino acids, is soluble, locates in Extracellular.

Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity), This toxin acts on sphingomyelin (SM) (By similarity), It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity), It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity), Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity)

Belongs to the arthropod phospholipase D family, Class II subfamily


This is Myosin-ID light chain protein, from Social amoeba, contains 147 amino acids, is soluble, locates in Cytoplasm.

Functions as the light chain for myosin-D, Has low affinity for calcium


This is Glucan 1,3-beta-glucosidase A protein, from Yellow koji mold, contains 405 amino acids, is soluble, locates in Extracellular.

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall, It could also function biosynthetically as a transglycosylase (By similarity)

Belongs to the glycosyl hydrolase 5 (cellulase A) family


This is Embryonic polyadenylate-binding protein 2-A protein, from African clawed frog, contains 218 amino acids, is soluble, locates in Cytoplasm.

Binds the poly(A) tail of mRNA, Unable to interact with the cap-binding complex and is therefore unlikely to be involved in translation initiation


This is Lysine-specific demethylase 9 protein, from Mouse, contains 795 amino acids, locates in Nucleus.

Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture

Belongs to the round spermatid basic protein 1 family


This is Musculoskeletal embryonic nuclear protein 1 protein, from Rat, contains 82 amino acids, locates in Nucleus.

May be involved in the development and regeneration of the musculoskeletal system


This is Receptor-transporting protein 2 protein, from Mouse, contains 223 amino acids, has 1 3CxxC-type Zinc finger, is membrane-bound, locates in Cell membrane.

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs


This is Collagen alpha-1(XXIII) chain protein, from Rat, contains 532 amino acids, is membrane-bound, locates in Cell membrane.


This is B3 domain-containing protein REM1 protein, from Mouse-ear cress, contains 517 amino acids, locates in Nucleus.


This is Protein DEHYDRATION-INDUCED 19 homolog 3 protein, from Mouse-ear cress, contains 223 amino acids, locates in Nucleus.


This is Taxoid 14-beta-hydroxylase protein, from Japanese yew, contains 509 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the conversion of 5-alpha-acetoxy-10beta-ol to 5-alpha-acetoxy-10beta,14beta-dihydroxy taxadiene, Also acts on taxa-4(20),11-dien-5-alpha-yl acetate


This is Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial protein, from Tomato, contains 417 amino acids, locates in Mitochondrion.

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA, The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit

Belongs to the succinate/malate CoA ligase beta subunit family


This is Gamma aminobutyrate transaminase 3, chloroplastic protein, from Tomato, contains 520 amino acids, locates in Plastid.

Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor, Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family


This is Gamma aminobutyrate transaminase 2 protein, from Tomato, contains 458 amino acids, is soluble, locates in Cytoplasm.

Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor, Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors, May be responsible for establishing the GABA gradient in the carpel


This is Gamma aminobutyrate transaminase 1, mitochondrial protein, from Tomato, contains 515 amino acids, locates in Mitochondrion.

Transaminase that degrades gamma-amino butyric acid (GABA) and uses pyruvate or glyoxylate as amino-group acceptor, Cannot use beta-alanine, ornithine, acetylornithine, serine, glycine, asparagine, glutamine, glutamate, valine, leucine, isoleucine, methionine, phenylalanine, histidine, lysine, arginine, aspartate, threonine, tyrosine, tryptophan, proline, or cysteine as amino donors, Acts predominantly in vegetative tissues


This is Fatty-acid-binding protein 2 protein, from Mouse-ear cress, contains 398 amino acids, is soluble, locates in Plastid.

Fatty-acid-binding protein, Associates with saturated fatty acid

Belongs to the chalcone isomerase family


This is NifU-like protein 3, chloroplastic protein, from Mouse-ear cress, contains 236 amino acids, is soluble, locates in Plastid.

Molecular scaffold for [Fe-S] cluster assembly of chloroplastic iron-sulfur proteins


This is Serine/threonine-protein kinase stt7, chloroplastic protein, from Chlamydomonas smithii, contains 754 amino acids, is membrane-bound, locates in Plastid.

Serine/threonine protein kinase required for state transition by phosphorylating light-harvesting complex II outer antennae (LCHII), State transition plays a central role in response to environmental changes and allows to adjust to changing light conditions via the redistribution of light excitation energy between photosystem II (PSII) and photosystem I (PSI)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Protein FRIGIDA-ESSENTIAL 1 protein, from Mouse-ear cress, contains 587 amino acids, has 1 C3H1-type Zinc finger, locates in Nucleus.

Transcriptional activator involved in the FRIGIDA-mediated vernalization pathway, but not in the autonomous flowering pathway, Acts cooperatively with FRI (FRIGIDA) or FRL1 (FRIGIDA-LIKE 1) to promote FLC (FLOWERING LOCUS C) expression, Required for the stabilization of the FRI-C complex


This is Subtilisin-like protease SBT1.1 protein, from Mouse-ear cress, contains 774 amino acids, is soluble, locates in Extracellular.

Serine protease that cleaves the phytosulfokines PSK3, PSK2 and PSK5 in vitro, Phytosulfokines are plant growth factors or peptide hormones that promotes plant cell differentiation, organogenesis and somatic embryogenesis as well as cell proliferation


This is ATP-dependent zinc metalloprotease FTSH 3, mitochondrial protein, from Mouse-ear cress, contains 809 amino acids, is membrane-bound, locates in Mitochondrion.

Probable ATP-dependent zinc metallopeptidase, Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system

In the C-terminal section; belongs to the peptidase M41 family


This is Transcription termination factor MTEF1, chloroplastic protein, from Mouse-ear cress, contains 284 amino acids, locates in Plastid.

Transcription termination factor required for plastid-specific rRNA accumulation and protein synthesis in plastids (PubMed:19563435), Essential for embryogenesis (PubMed:12324593, PubMed:19563435)


This is CAX-interacting protein 4 protein, from Mouse-ear cress, contains 332 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type


This is Potassium channel toxin alpha-KTx 15.4 protein, from Sahara scorpion, contains 59 amino acids, is soluble, locates in Extracellular.

Blocker of A-type voltage-gated potassium channels of cerebellar granular cells (PubMed:11018665), May also inhibit Kv4/KCND when coexpressed with DPP6 or DPP10 (By similarity), The occlusion of the outer entry of the K(+) conducting pore is partially reversible and affects both open and closed channels (PubMed:11018665), It shares the same target in rat brain than BmTX3 (AC Q8I0L5) and AmmTX3 (AC P60208)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 15 subfamily


This is Mitochondrial-processing peptidase subunit alpha-1 protein, from Social amoeba, contains 654 amino acids, is soluble, locates in Mitochondrion.

Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins


This is Protein disulfide-isomerase 1 protein, from Social amoeba, contains 363 amino acids, is soluble, locates in Endoplasmic reticulum.

Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer

Belongs to the protein disulfide isomerase family


This is Pickpocket protein 28 protein, from Fruit fly, contains 606 amino acids, is membrane-bound, locates in Cell membrane.

Osmosensitive ion channel that mediates the cellular and behavioral response to water, Plays an essential role in gustatory water reception, Part of a complex that plays a role in tracheal liquid clearance, Probable role in sodium transport

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family


This is Scarabaecin protein, from Coconut rhinoceros beetle, contains 66 amino acids, is soluble, locates in Extracellular.

Possesses antifungal activity against phytopathogenic fungi such as P,oryzae, R,solani and B,cinerea but not against phytopathogenic bacteria, Shows weak activity against the insect pathogenic fungus B,bassiana and against S,aureus, Binds chitin


This is Insulin-like growth factor-binding protein 3 receptor protein, from Human, contains 240 amino acids, is membrane-bound, locates in Cell membrane.

Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding


This is Zinc finger protein 354C protein, from Human, contains 554 amino acids, has 11 C2H2-type Zinc finger, locates in Nucleus.

May function as a transcription repressor, Binds to 5'-CCACA-3' core sequence, Suppresses osteogenic effects of RUNX2, May be involved in osteoblastic differentiation (By similarity), Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Endo-chitosanase protein, from Neosartorya fumigata, contains 238 amino acids, is soluble, locates in Extracellular.

Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin, Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall, Chitoolisaccharides produced by the hydrolysis of partially N-acetylated chitosan are known to have many biological activities, including antibacterial activity, immune-enhancing effects, and elicitor activity, The chitosans with higher degrees of deacetylation were shown to be the better substrates, Chitodimer, chitotrimer, and chitotetramer are the major products but monoacetyl chitodimer, monoacetyl chitotrimer, and monoacetyl chitotetramer are also produced

Belongs to the glycosyl hydrolase 75 family


This is Kinetochore protein NDC80 homolog protein, from African clawed frog, contains 638 amino acids, locates in Nucleus.

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12514103, PubMed:14738735), Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore, The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules, May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores to spindle microtubules (By similarity)


This is Transcription cofactor vestigial-like protein 2 protein, from Mouse, contains 322 amino acids, locates in Nucleus.

May act as a specific coactivator for the mammalian TEFs, May play a role in the development of skeletal muscles


This is Cleavage stimulation factor subunit 2 protein, from Mouse, contains 580 amino acids, locates in Nucleus.

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs, This subunit is directly involved in the binding to pre-mRNAs (By similarity)


This is Phospholipid phosphatase-related protein type 5 protein, from Mouse, contains 321 amino acids, is membrane-bound, locates in Cell membrane.

Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction

Belongs to the PA-phosphatase related phosphoesterase family


This is Choline dehydrogenase, mitochondrial protein, from Mouse, contains 596 amino acids, is membrane-bound, locates in Mitochondrion.

Belongs to the GMC oxidoreductase family


This is Protein mab-21-like 2 protein, from Mouse, contains 359 amino acids, locates in Nucleus.

Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning


This is Four-jointed box protein 1 protein, from Mouse, contains 450 amino acids, is soluble, locates in Extracellular.

Acts as an inhibitor of dendrite extension and branching


This is Coiled-coil and C2 domain-containing protein 1B protein, from Mouse, contains 848 amino acids, locates in Nucleus.

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells


This is Methionine-R-sulfoxide reductase B3, mitochondrial protein, from Mouse, contains 253 amino acids, locates in Endoplasmic reticulum.

Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine

Belongs to the MsrB Met sulfoxide reductase family


This is Mitotic-spindle organizing protein 1 protein, from Mouse, contains 78 amino acids, is soluble, locates in Cytoplasm.

Required for gamma-tubulin complex recruitment to the centrosome


This is ADP-ribosylation factor-related protein 1 protein, from Mouse, contains 201 amino acids, locates in Golgi apparatus.

Trans-Golgi-associated GTPase that regulates protein sorting, Controls the targeting of ARL1 and its effector to the trans-Golgi, Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver

Belongs to the small GTPase superfamily, Arf family


This is Protein phosphatase 1K, mitochondrial protein, from Mouse, contains 372 amino acids, is soluble, locates in Mitochondrion.

Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development


This is Protein-glutamine gamma-glutamyltransferase 4 protein, from Mouse, contains 670 amino acids, is soluble, locates in Extracellular.

Associated with the mammalian reproductive process, Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma, Transglutaminase is also required to stabilize the copulatory plug

Belongs to the transglutaminase superfamily, Transglutaminase family


This is Active regulator of SIRT1 protein, from Mouse, contains 143 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome, Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1, Direct regulator of SIRT1, Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity


This is Cleavage stimulation factor subunit 2 tau variant protein, from Mouse, contains 632 amino acids, locates in Nucleus.

May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells, Directly involved in the binding to pre-mRNAs


This is Receptor-transporting protein 1 protein, from Mouse, contains 263 amino acids, has 1 3CxxC-type Zinc finger, is membrane-bound, locates in Cell membrane.

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs


This is Gigaxonin protein, from Mouse, contains 597 amino acids, is soluble, locates in Cytoplasm.

Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture, May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Controls degradation of TBCB (By similarity), Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival


This is Dynactin subunit 4 protein, from Mouse, contains 467 amino acids, is soluble, locates in Cytoplasm.

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules

Belongs to the dynactin subunit 4 family


This is BTB/POZ domain-containing protein KCTD20 protein, from Mouse, contains 419 amino acids, is soluble, locates in Cytoplasm.

Promotes the phosphorylation of AKT family members


This is Serine protease inhibitor kazal-like protein, minor form protein, from Mouse, contains 90 amino acids, is soluble, locates in Extracellular.

Does not function as an inhibitor of trypsin, chymotrypsin, subtilisin or elastase, Binds sperm and enhances sperm motility, May act as a decapacitation factor, suppresses BSA-stimulated sperm capacitation and blocks sperm-oocyte interactions in vitro


This is Sideroflexin-5 protein, from Rat, contains 342 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial amino-acid transporter (By similarity), Transports citrate (PubMed:12150972), Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity) (PubMed:12150972), In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization (By similarity)


This is NEP1-interacting protein 2 protein, from Mouse-ear cress, contains 241 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Plastid.

RING-type; atypical

Intrinsic thylakoid membrane protein that fixes RPOT2 on the stromal side of the thylakoid membrane

Belongs to the RING-type zinc finger family, NIP subfamily


This is Succinate--CoA ligase [ADP-forming] subunit alpha-1, mitochondrial protein, from Tomato, contains 332 amino acids, locates in Mitochondrion.

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA, The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit

Belongs to the succinate/malate CoA ligase alpha subunit family


This is Basic leucine zipper 23 protein, from Mouse-ear cress, contains 249 amino acids, locates in Nucleus.

Transcription factor involved in the response to zinc ion deficiency, Binds to the consensus sequence 5'-[AG]TGTCGACA[CT]-3' also called zinc deficiency response element (ZDRE), The ZDRE sequence is conserved in the plant kingdom and present in the promoters of genes that constitute the primary response to zinc deficiency, comprising additional ZIP metal transporter genes (PubMed:20479230, PubMed:26306426), Required for zinc accumulation in roots, Mediates the expression of the zinc transporter ZIP12 during growth in zinc-deficient conditions, ZIP12 transporter is involved in zinc uptake in roots (PubMed:26306426)


This is Cleavage and polyadenylation specificity factor subunit 3-II protein, from Mouse-ear cress, contains 613 amino acids, locates in Nucleus.

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition, May function as mRNA 3'-end-processing endonuclease and also be involved in the histone 3'-end pre-mRNA processing

Belongs to the metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, INTS11 subfamily


This is Alpha-L-fucosidase 1 protein, from Mouse-ear cress, contains 506 amino acids, is soluble, locates in Extracellular.

Hydrolyzes both 3- and 4-linked fucoses in Lewis determinants, Not active on neither 2-linked fucose nor on fucose in alpha-1,3-linkage to the innermost GlcNAc

Belongs to the glycosyl hydrolase 29 family


This is Membrane-anchored ubiquitin-fold protein 6 protein, from Mouse-ear cress, contains 119 amino acids, is membrane-bound, locates in Cell membrane.

May serve as docking site to facilitate the association of other proteins to the plasma membrane


This is Riboflavin biosynthesis protein PYRD, chloroplastic protein, from Mouse-ear cress, contains 426 amino acids, locates in Plastid.

Monofunctional pyrimidine deaminase involved in the riboflavin biosynthesis pathway, Has also a reductase domain that lacks catalytically essential substrate-binding residues


This is UPF0235 protein At5g63440 protein, from Mouse-ear cress, contains 232 amino acids, locates in Nucleus.

May play a role during early embryonic development, Probably involved in pre-mRNA splicing (By similarity)


This is Protein OSB2, chloroplastic protein, from Mouse-ear cress, contains 371 amino acids, locates in Plastid.

Binds preferentially single-stranded DNA, Does not bind to RNA


This is SEC12-like protein 1 protein, from Mouse-ear cress, contains 398 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in Pi uptake by facilitating the trafficking of PHT1-1/PHT1;1 from the endoplasmic reticulum to the plasma membrane


This is AUGMIN subunit 4 protein, from Mouse-ear cress, contains 423 amino acids, is soluble, locates in Cytoplasm.

Involved in microtubules reorganization during spindle and phragmoplast development


This is 1,4-dihydroxy-2-naphthoyl-CoA synthase, peroxisomal protein, from Mouse-ear cress, contains 337 amino acids, locates in Peroxisome.

Involved in the biosynthesis of phylloquinone (vitamin K1), Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) (By similarity)

Belongs to the enoyl-CoA hydratase/isomerase family, MenB subfamily


This is Microtubule-associated protein 70-5 protein, from Mouse-ear cress, contains 513 amino acids, is soluble, locates in Cytoplasm.

Plant-specific protein that interact with microtubules and regulates microtubule dynamics, May play a role in anisotropic cell expansion and organ growth, In association with MAP70,1, is essential for the normal banding pattern of secondary cell wall and for the proper development of xylem tracheary elements and wood formation


This is RNA-binding protein BRN2 protein, from Mouse-ear cress, contains 429 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein involved in the regulation of flowering time, Acts as repressor of the activity of SOC1, a transcriptional activator of flowering time, Binds to the 3'-UTR of SOC1 mRNA in the cytoplasm and participates in SOC1 mRNA decay, mediated by the distal region of the SOC1 3'-UTR


This is Protein TIC 20-I, chloroplastic protein, from Mouse-ear cress, contains 274 amino acids, is membrane-bound, locates in Plastid.

Involved in protein precursor import into chloroplasts, May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope, Seems to be specific for photosynthesis-related pre-proteins, Partially redundant with TIC20-IV, but not with TIC20-II or TIC20-V


This is Bifunctional desaturase/conjugase FADX protein, from Tung, contains 386 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Converts linoleic acid to alpha-eleostearic acid (18:3(9Z,11E,13E)) and alpha-linolenic acid to alpha-parinaric acid (18:4(9Z,11E,13E,15Z)), Converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13, Can also act as a 12(E) desaturase when acting on the monounsaturated fatty acids oleate and palmitoleate, stereoselectively introducing a trans double bond

Belongs to the fatty acid desaturase type 1 family


This is Cytochrome f, chloroplastic protein, from Euglena gracilis, contains 496 amino acids, is membrane-bound, locates in Plastid.

Translocates protons across the thylakoid membrane and transfers electrons from photosystem II to photosystem I, It receives electrons from the Rieske iron-sulfur protein and passes them to plastocyanin


This is PTI1-like tyrosine-protein kinase 1 protein, from Mouse-ear cress, contains 361 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is Thylakoid lumenal protein TL20.3, chloroplastic protein, from Mouse-ear cress, contains 280 amino acids, locates in Plastid.

Pentapeptide repeat protein of unknown function, Subject to degradation when reduced


This is Pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial protein, from Mouse-ear cress, contains 393 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)


This is Exportin-T protein, from Rice, contains 980 amino acids, locates in Cytoplasm.

Probable tRNA nucleus export receptor which regulates tRNA processing and facilitates tRNA translocation across the nuclear pore complex, Is required for correct leaf initiation at different developmental stages and may play a role in floral patterning


This is Enticin protein, from California sea hare, contains 88 amino acids, is soluble, locates in Extracellular.

A component of the complex of water-borne protein pheromones that stimulates attraction and mating behavior


This is Myb1 protein protein, from Plasmodium falciparum (isolate 3D7), contains 414 amino acids, locates in Nucleus.

Transcriptional activator, Has a role in the parasite erythrocytic cycle where it directly regulates key genes involved in cell cycle regulation and progression, Binds directly to Myb regulatory elements


This is Hemocyanin subunit B protein, from House centipede, contains 659 amino acids, is soluble, locates in Extracellular.

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods

Belongs to the tyrosinase family, Hemocyanin subfamily


This is Thioredoxin-T protein, from Fruit fly, contains 157 amino acids, locates in Nucleus.

Probably participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions, Its tissue specificity suggests a regulatory role in the germline


This is Protein Turandot X protein, from Fruit fly, contains 142 amino acids, is soluble, locates in Extracellular.

A humoral factor that may play a role in stress tolerance


This is Protein Turandot Z protein, from Fruit fly, contains 147 amino acids, is soluble, locates in Extracellular.


This is Protein Turandot E protein, from Fruit fly, contains 134 amino acids, is soluble, locates in Extracellular.


This is Seven in absentia homolog 3 protein, from Human, contains 269 amino acids, has 1 SIAH-type; degenerate Zinc finger, locates in Mitochondrion.

SIAH-type; degenerate

Negative regulator of PRKN translocation to damaged mitochondria, Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria

Belongs to the SINA (Seven in absentia) family


This is Interferon lambda-2 protein, from Human, contains 200 amino acids, is soluble, locates in Extracellular.

Cytokine with antiviral, antitumour and immunomodulatory activities, Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues, Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state, Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1, Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense, Plays a significant role in the antiviral immune defense in the intestinal epithelium, Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression


This is Extracellular metalloproteinase 1 protein, from Microsporum canis, contains 632 amino acids, is soluble, locates in Extracellular.

Secreted metalloproteinase probably acting as a virulence factor


This is Muscarinic toxin BM14 protein, from Many-banded krait, contains 103 amino acids, is soluble, locates in Extracellular.

This toxin inhibits the binding of [3H]quinuclidinyl benzilate to the M2 muscarinic acetylcholine (mAchR) receptor subtype (CHRM2)

Belongs to the snake three-finger toxin family, Ancestral subfamily, Orphan group XVII sub-subfamily


This is Repulsive guidance molecule A protein, from Chicken, contains 432 amino acids, is membrane-bound, locates in Cell membrane.

Acts as an axon-specific repulsive guidance molecule in the retinotectal system, Repulsive for a subset of axons of the temporal half of the retina, Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum

Belongs to the repulsive guidance molecule (RGM) family


This is Polycomb complex protein BMI-1-A protein, from Zebrafish, contains 320 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of rnf2


This is Ubiquinone biosynthesis protein COQ9, mitochondrial protein, from Mouse, contains 313 amino acids, locates in Mitochondrion.

Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25339443), Binds a phospholipid of at least 10 carbons in each acyl group, May be required to present its bound-lipid to COQ7 (By similarity)


This is Bromodomain-containing protein 3 protein, from Mouse, contains 726 amino acids, locates in Nucleus.

Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:21536911), Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (PubMed:21536911)


This is DNA repair protein SWI5 homolog protein, from Mouse, contains 89 amino acids, locates in Nucleus.

Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination


This is Actin-binding Rho-activating protein protein, from Rat, contains 375 amino acids, is soluble, locates in Cytoplasm.

Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling


This is B3 domain-containing transcription factor VRN1 protein, from Mouse-ear cress, contains 341 amino acids, locates in Nucleus.

Involved in the regulation of vernalization, Acts as transcriptional repressor of FLC, a major target of the vernalization pathway, Binds DNA in vitro in a non-sequence-specific manner


This is Seipin-3 protein, from Mouse-ear cress, contains 509 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size, Supports the formation of small-sized LDs and modulates triacylglycerol accumulation, Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains


This is THO complex subunit 4B protein, from Mouse-ear cress, contains 292 amino acids, is soluble, locates in Nucleus.

Export adapter involved in nuclear export of spliced and unspliced mRNA


This is ATP-dependent Clp protease proteolytic subunit-related protein 3, chloroplastic protein, from Mouse-ear cress, contains 330 amino acids, locates in Plastid.


This is Shewanella-like protein phosphatase 1 protein, from Mouse-ear cress, contains 389 amino acids, locates in Plastid.

Shows phosphatase activity, hydrolyzing the artificial substrate para-nitrophenylphosphate (pNPP) in vitro

Belongs to the metallophosphoesterase superfamily, SLP family


This is Chaperonin CPN60-like 1, mitochondrial protein, from Mouse-ear cress, contains 585 amino acids, locates in Mitochondrion.

Implicated in mitochondrial protein import and macromolecular assembly, May facilitate the correct folding of imported proteins, May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity)

Belongs to the chaperonin (HSP60) family


This is Mechanosensitive ion channel protein 3, chloroplastic protein, from Mouse-ear cress, contains 678 amino acids, is membrane-bound, locates in Plastid.

Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer, Controls plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension, Acts as a component of the chloroplast division machinery


This is Succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial protein, from Mouse-ear cress, contains 341 amino acids, locates in Mitochondrion.

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA, The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit


This is SPX domain-containing protein 1 protein, from Mouse-ear cress, contains 256 amino acids, locates in Nucleus.

Plays a positive role in plant adaptation to phosphate starvation (PubMed:18315545), Inhibits PHR1 DNA-binding activity in a Pi-dependent manner (PubMed:25271326)


This is Monothiol glutaredoxin-S15, mitochondrial protein, from Mouse-ear cress, contains 169 amino acids, locates in Mitochondrion.

May only reduce GSH-thiol disulfides, but not protein disulfides, Participates probably to the maturation of iron-sulfur proteins and to the regulation of the redox state of the BOLA proteins

Belongs to the glutaredoxin family, CGFS subfamily


This is Membrane-anchored ubiquitin-fold protein 2 protein, from Mouse-ear cress, contains 124 amino acids, is membrane-bound, locates in Cell membrane.

May serve as docking site to facilitate the association of other proteins to the plasma membrane


This is Thioredoxin X, chloroplastic protein, from Mouse-ear cress, contains 182 amino acids, is soluble, locates in Plastid.

Probable thiol-disulfide oxidoreductase that may participate in various redox reactions


This is Protein CURVATURE THYLAKOID 1D, chloroplastic protein, from Mouse-ear cress, contains 193 amino acids, is membrane-bound, locates in Plastid.

Determines thylakoid architecture by inducing membrane curvature


This is Probable tetraacyldisaccharide 4'-kinase, mitochondrial protein, from Mouse-ear cress, contains 395 amino acids, locates in Mitochondrion.

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell, Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA), Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential)


This is Thioredoxin-like 2-1, chloroplastic protein, from Mouse-ear cress, contains 221 amino acids, is soluble, locates in Plastid.

Thiol-disulfide oxidoreductase that may participate in various redox reactions, Possesses insulin disulfide bonds reducing activity


This is Tonoplast dicarboxylate transporter protein, from Mouse-ear cress, contains 540 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Putative carrier protein indirectly involved in the uptake of malate and fumarate to the vacuole, probably by regulating the energization across the tonoplast, Uptake of malate to vacuoles is inhibited by citrate and by the uncoupler carbonyl-cyanide m-chlorophenylhydrazone, but seems to be not affected by sodium, Critical for pH homeostasis

Belongs to the SLC13A/DASS transporter (TC 2,A,47) family


This is Protein MKS1 protein, from Mouse-ear cress, contains 222 amino acids, locates in Nucleus.

Regulator of plant defense response, May contribute to MPK4-regulated defense activation by coupling the kinase to specific WRKY transcription factors


This is Pentatricopeptide repeat-containing protein At2g02980, chloroplastic protein, from Mouse-ear cress, contains 603 amino acids, locates in Plastid.

Involved in RNA editing event in chloroplasts, Required for the editing of a single site in ndhD transcript, which is a plastid-encoded subunits of the chloroplast NAD(P)H dehydrogenase (NDH) complex, Not essential for the activity of the NDH complex of the photosynthetic electron transport chain

Belongs to the PPR family, PCMP-H subfamily


This is Protein NRT1/ PTR FAMILY 1.1 protein, from Mouse-ear cress, contains 591 amino acids, is membrane-bound, locates in Cell membrane.

Low-affinity nitrate transporter involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, Not involved in dipeptides transport

Belongs to the major facilitator superfamily, Proton-dependent oligopeptide transporter (POT/PTR) (TC 2,A,17) family


This is Phytochrome-associated serine/threonine-protein phosphatase protein, from Garden pea, contains 303 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of protein phosphatase 6 (PP6) (Probable), Dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms, Plays a major role in the photoperiodic control of flowering time in long days by modulating phytochrome signals in flowering time control

Belongs to the PPP phosphatase family, PP-6 (PP-V) subfamily


This is Oxysterol-binding protein 1 protein, from Social amoeba, contains 389 amino acids, is soluble, locates in Cytoplasm.

May play a role in the regulation of the slug-fruiting body switch


This is Salivary cystatin-L protein, from Black-legged tick, contains 133 amino acids, is soluble, locates in Extracellular.

Inhibitor of cysteine proteinases, Inhibits host immune responses via its inhibition of host cathepsins (PubMed:19494265), Contributes to the suppression of the host's immune response to tick salivary proteins and is important for successful feeding on hosts (PubMed:17698852), Inhibits differentiation of host dendritic cells (PubMed:19494265, PubMed:25975355), Inhibits proliferation of host T-cells in response to antigen stimulus (PubMed:19494265), Down-regulates TLR2-mediated host responses to infection by B,burgdorferi and the production of the chemokine CCL3 by host dendritic cells (PubMed:25975355), Down-regulates host responses to infection by B,burgdorferi and the production of IFNB1 by host dendritic cells (PubMed:25975355), Down-regulates IL1B production by host mast cells, and this then leads to impaired activation of IL1R1, resulting in decreased IL9 production (PubMed:26078269), Inhibits host inflammatory reactions and recruitment of host neutrophils (PubMed:16772304), Inhibits papain and cathepsin-L (CTSL) (in vitro) (PubMed:16772304, PubMed:17698852, PubMed:20545851), Inhibits cathepsin-S (CTSS) (in vitro) (PubMed:17698852, PubMed:20545851), Inhibits CTSV and CTSC, but to a lesser degree (in vitro) (PubMed:16772304, PubMed:17698852)


This is Serine/threonine-protein kinase PDIK1L protein, from Human, contains 341 amino acids, locates in Nucleus.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Protein GAPT protein, from Human, contains 157 amino acids, is membrane-bound, locates in Cell membrane.

Negatively regulates B-cell proliferation following stimulation through the B-cell receptor, May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity)


This is Mitochondrial import receptor subunit TOM5 homolog protein, from Human, contains 51 amino acids, is membrane-bound, locates in Mitochondrion.


This is Rho guanine nucleotide exchange factor 39 protein, from Human, contains 335 amino acids, is membrane-bound, locates in Cell membrane.


This is Potassium channel regulatory protein protein, from Human, contains 272 amino acids, locates in Endoplasmic reticulum.

Inhibits potassium fluxes in cells, May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes


This is Kelch domain-containing protein 1 protein, from Human, contains 406 amino acids, is soluble, locates in Cytoplasm.

Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:32200094), The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:32200094), The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (PubMed:32200094)


This is HORMA domain-containing protein 2 protein, from Human, contains 307 amino acids, locates in Nucleus.

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity, Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes, Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity)


This is Zinc finger and BTB domain-containing protein 34 protein, from Human, contains 500 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.


This is Short-chain dehydrogenase/reductase family 9C member 7 protein, from Human, contains 313 amino acids, is soluble, locates in Cytoplasm.

Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH, Has apparently no steroid dehydrogenase activity

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Endo-1,4-beta-xylanase 6 protein, from Crabgrass-specific blast fungus, contains 380 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Endochitinase 37 protein, from Hypocrea lixii, contains 337 amino acids, is soluble, locates in Extracellular.

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods), Plays a morphogenetic role during apical growth, cell division and differentiation (cell wall morphogenesis), May be involved in the degradation and further assimilation of phytopathogenic fungi, namely mycoparasitism, the major mechanism accounting for the antagonistic activity against phytopathogenic fungi displayed by Trichoderma

Belongs to the glycosyl hydrolase 18 family, Chitinase class V subfamily


This is ATP-dependent 6-phosphofructokinase subunit alpha protein, from Yeast, contains 989 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Belongs to the phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade 'E' sub-subfamily


This is Alpha-L-arabinofuranosidase A protein, from White koji mold, contains 628 amino acids, is soluble, locates in Extracellular.

Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose, Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides

Belongs to the glycosyl hydrolase 51 family


This is Acidic phospholipase A2 BITP01A protein, from Golden lancehead, contains 138 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that induces edema in mice, produces neuromuscular blockade in chick biventer cervicis, increases CK release and produces myonecrosis, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is Cadherin-20 protein, from Chicken, contains 798 amino acids, is membrane-bound, locates in Cell membrane.

Cadherins are calcium-dependent cell adhesion proteins, They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types


This is Protein ripply2.1 protein, from African clawed frog, contains 121 amino acids, locates in Nucleus.

Required during somitogenesis to regulate somite differentiation and the positioning of the presomitic mesoderm-front, Represses the expression of genes involved in somite segmentation by acting with the corepressor tle4 to down-regulate the transcriptional activity of tbx6, Also regulates retinoic acid signaling during somitogenesis and is necessary for the expression of aldh1a2/raldh2


This is Hydroxyacid-oxoacid transhydrogenase, mitochondrial protein, from Mouse, contains 465 amino acids, locates in Mitochondrion.

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG), L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity)

Belongs to the iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily


This is Mth938 domain-containing protein protein, from Mouse, contains 122 amino acids, is soluble, locates in Cytoplasm.

May play a role in preadipocyte differentiation and adipogenesis


This is Mitoferrin-2 protein, from Mouse, contains 364 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial iron transporter that mediates iron uptake, Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Transmembrane emp24 domain-containing protein 4 protein, from Mouse, contains 227 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vesicular protein trafficking, mainly in the early secretory pathway, Involved in the maintenance of the Golgi apparatus, Appears to play a role in the biosynthesis of secreted cargo including processing, Involved in endoplasmic reticulum stress response, May play a role in the regulation of heat-shock response and apoptosis (By similarity)


This is Germ cell-specific gene 1 protein protein, from Mouse, contains 324 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum


This is Nucleolus and neural progenitor protein protein, from Mouse, contains 564 amino acids, locates in Nucleus.

May play a role in cortex development as part of the Notch signaling pathway, Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors (PubMed:19906856), May also play a role in preimplentation embryo development (PubMed:26178919)


This is UBX domain-containing protein 11 protein, from Rat, contains 485 amino acids, is soluble, locates in Cytoplasm.

May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 and RND3, Promotes RHOA activation mediated by GNA12 and GNA13


This is Zinc fingers and homeoboxes protein 1 protein, from Rat, contains 873 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Acts as a transcriptional repressor, Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA, May link molecule between DNMT3B and other co-repressor proteins (By similarity)


This is Protein CLT3, chloroplastic protein, from Mouse-ear cress, contains 452 amino acids, is membrane-bound, locates in Plastid.

Involved in thiol transport from the plastid to the cytosol, Transports probably both glutathione (GSH) and its precursor, gamma-glutamylcysteine (gamma-EC), Exhibits some functional redundancy with CLT1 in maintaining the root GSH pool

Belongs to the CRT-like transporter family


This is Protein ZINC INDUCED FACILITATOR 1 protein, from Mouse-ear cress, contains 486 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Major facilitator superfamily (MFS) transporter involved in zinc tolerance by participating in vacuolar sequestration of zinc

Belongs to the major facilitator superfamily


This is Nucleoside diphosphate kinase 4, chloroplastic protein, from Spinach, contains 235 amino acids, locates in Plastid.

Major role in the synthesis of nucleoside triphosphates other than ATP, The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate, Shows the highest specificity towards GDP (By similarity)


This is Photosynthetic NDH subunit of subcomplex B 4, chloroplastic protein, from Mouse-ear cress, contains 175 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient


This is ABSCISIC ACID-INSENSITIVE 5-like protein 1 protein, from Mouse-ear cress, contains 331 amino acids, locates in Nucleus.

Could participate in abscisic acid-regulated gene expression during seed development

Belongs to the bZIP family, ABI5 subfamily


This is Protein GRIP protein, from Mouse-ear cress, contains 788 amino acids, locates in Golgi apparatus.

Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus


This is Serine acetyltransferase 2 protein, from Mouse-ear cress, contains 323 amino acids, is soluble, locates in Cytoplasm.

Belongs to the transferase hexapeptide repeat family


This is PHD finger protein ALFIN-LIKE 6 protein, from Mouse-ear cress, contains 256 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Golgin candidate 1 protein, from Mouse-ear cress, contains 707 amino acids, is membrane-bound, locates in Golgi apparatus.


This is Probable plastid-lipid-associated protein 13, chloroplastic protein, from Mouse-ear cress, contains 299 amino acids, is soluble, locates in Plastid.


This is Protein TIC 62, chloroplastic protein, from Garden pea, contains 534 amino acids, is membrane-bound, locates in Plastid.

Involved in protein precursor import into chloroplasts, Part of the redox regulon consisting of TIC32, TIC 55 and TIC62, Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids


This is Sex peptide receptor protein, from Fruit fly, contains 435 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior (PubMed:18066048, PubMed:20458515, PubMed:20308537, PubMed:24089336, PubMed:25333796), MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons (PubMed:25333796), SP-SPR is one of the multiple SP pathways that induce female post-mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying (PubMed:18066048, PubMed:24089336), The PMR switch is achieved by mediating the synaptic output of neurons such as those expressing fruitless (fru), double sex (dsx) and pickpocket (ppk) (PubMed:18066048, PubMed:24089336)

Belongs to the G-protein coupled receptor 1 family


This is Neuropeptides CP2 protein, from California sea hare, contains 141 amino acids, is soluble, locates in Extracellular.


This is Retinoic acid receptor RXR protein, from Bloodfluke planorb, contains 436 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Ligand-dependent transcription factor probably involved in the retinoic acid response pathway, Binds 9-cis-retinoic acid (9C-RA) and, to a lesser extent, docosahexaenoic acid (DHA), phytanic acid, methoprene acid and oleic acid, Binds to double-stranded DNA sequences containing direct repeats (DR) with the consensus sequence 5'-[AG]GGTCA-3' and 1, 2, 3, 4 or 5 nucleotides in between (DR1, DR2, DR3, DR4 and DR5, respectively), Binding to DR1 is strongest, Transactivates gene expression when 9C-RA or DHA is bound

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Stomoxyn protein, from Stable fly, contains 67 amino acids, is soluble, locates in Extracellular.

May play an important role in protecting the stored blood in the anterior midgut from microorganisms prior to digestion, Adopts an amphipathic alpha-helical structure only in the presence of an organic solvent that mimics a phospholipid membrane


This is Zinc finger CCHC-type and RNA-binding motif-containing protein 1 protein, from Human, contains 217 amino acids, has 1 CCHC-type Zinc finger, is soluble, locates in Nucleus.

CCHC-type


This is Protein kish-A protein, from Human, contains 72 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in the early part of the secretory pathway


This is Coiled-coil domain-containing protein 110 protein, from Human, contains 833 amino acids, locates in Nucleus.


This is Golgi-associated RAB2 interactor protein 3 protein, from Human, contains 605 amino acids, locates in Nucleus.


This is Protein FAM110B protein, from Human, contains 370 amino acids, is soluble, locates in Cytoplasm.


This is Nucleoredoxin-like protein 1 protein, from Mouse, contains 217 amino acids, is membrane-bound, locates in Nucleus.

Plays an important role in retinal cone photoreceptor survival (PubMed:25957687), In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687), May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (PubMed:15220920)


This is Mitochondrial fission regulator 2 protein, from Mouse, contains 361 amino acids, locates in Mitochondrion.

May play a role in mitochondrial aerobic respiration essentially in the testis, Can also promote mitochondrial fission


This is Kelch domain-containing protein 3 protein, from Mouse, contains 382 amino acids, is soluble, locates in Cytoplasm.

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation, The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms, The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons, The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (By similarity), May be involved in meiotic recombination process (PubMed:12606021)


This is Calcium-responsive transcription factor protein, from Mouse, contains 689 amino acids, locates in Nucleus.

Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription, Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity)


This is Nucleolar complex protein 3 homolog protein, from Mouse, contains 807 amino acids, locates in Nucleus.


This is Geraniol 8-hydroxylase protein, from Madagascar periwinkle, contains 493 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Hydroxylase involved in the biosynthesis of hydroxygeraniol, a precursor of the terpenoid indole alkaloids such as vinblastine and vincristine, Also able to hydroxylate in vitro nerol and to catalyze 3'-hydroxylation of the flavanone naringenin to form eriodictyol, No activity with apigenin, kaempferol, p-coumaric acid and ferulic acid as substrates


This is Aldehyde dehydrogenase protein, from Blue gem, contains 479 amino acids, locates in Plastid.

Oxidizes nonanal, propionaldehyde and acetaldehyde in vitro, in the following decreasing order of reactivity: nonanal, propionaldehyde, acetaldehyde

Belongs to the aldehyde dehydrogenase family


This is Protein DJ-1 homolog C protein, from Mouse-ear cress, contains 472 amino acids, locates in Plastid.

Plays an essential role in chloroplast development and is required for chloroplast integrity and viability


This is Basic leucine zipper 19 protein, from Mouse-ear cress, contains 261 amino acids, locates in Nucleus.

Transcription factor involved in the response to zinc ion deficiency, Binds to the consensus sequence 5'-[AG]TGTCGACA[CT]-3' also called zinc deficiency response element (ZDRE), The ZDRE sequence is conserved in the plant kingdom and present in the promoters of genes that constitute the primary response to zinc deficiency, comprising additional ZIP metal transporter genes (PubMed:20479230, PubMed:26306426), Required for zinc accumulation in roots, Mediates the expression of the zinc transporters ZIP3, ZIP4, ZIP5 and ZIP9 during growth in zinc-deficient conditions, ZIP9 transporter is involved in zinc uptake in roots (PubMed:26306426)


This is ATG8-interacting protein 2 protein, from Mouse-ear cress, contains 266 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in salt stress-induced vesicle-to-vacuole trafficking pathway, Through its interaction with ATG8F, may enable delivery of the vesicle bodies to the vacuole by an autophagic pathway (Probable), Plays a role in seed germination in response to exogenous abscisic acid (ABA) treatment (PubMed:22253227)


This is LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-like 1.3 protein, from Mouse-ear cress, contains 686 amino acids, is membrane-bound, locates in Cell membrane.


This is ATP-dependent zinc metalloprotease FTSH 10, mitochondrial protein, from Mouse-ear cress, contains 813 amino acids, is membrane-bound, locates in Mitochondrion.

Probable ATP-dependent zinc metallopeptidase, Involved in the assembly and/or stability of the complexes I and V of the mitochondrial oxidative phosphorylation system

In the C-terminal section; belongs to the peptidase M41 family


This is FAD synthetase 2, chloroplastic protein, from Mouse-ear cress, contains 367 amino acids, locates in Plastid.

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme


This is GBF-interacting protein 1 protein, from Mouse-ear cress, contains 567 amino acids, locates in Nucleus.

Plant specific protein that enhances G-box-binding factor (GBF) DNA binding activity, May function as a nuclear chaperone or lever and regulate the multimeric state of GBFs, May contribute to bZIP-mediated gene regulation, Is able to refold denatured rhodanese in vitro (PubMed:16117846, PubMed:25387999), Reduces DNA-binding activity of BZIP16, BZIP68 and GBF1 under non-reducing conditions through direct physical interaction, Acts as negative co-regulator in red and blue light-mediated hypocotyl elongation, Functions to promote hypocotyl elongation during the early stages of seedling development by regulating the repression effect by BZIP16 and the activation effect by BZIP68 and GBF1 on LHCB2,4 expression (PubMed:25387999), Enhances transcriptional activity of LBD18 in the EXP14 promoter, May act as a transcriptional coactivator of LBD18 (PubMed:24484953)


This is Aquaporin NIP2-1 protein, from Mouse-ear cress, contains 288 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Low water transport activity in yeast cells

Belongs to the MIP/aquaporin (TC 1,A,8) family, NIP (TC 1,A,8,12) subfamily


This is CLAVATA3/ESR (CLE)-related protein 19 protein, from Mouse-ear cress, contains 74 amino acids, is soluble, locates in Extracellular.

Extracellular signal peptide that regulates cell fate, Represses root apical meristem maintenance

Belongs to the CLV3/ESR signal peptide family


This is Serine acetyltransferase 4 protein, from Mouse-ear cress, contains 355 amino acids, is soluble, locates in Cytoplasm.


This is O-fucosyltransferase 1 protein, from Mouse-ear cress, contains 519 amino acids, is membrane-bound, locates in Golgi apparatus.

Belongs to the glycosyltransferase GT106 family


This is Inactive GDSL esterase/lipase-like protein 23 protein, from Mouse-ear cress, contains 386 amino acids, locates in Endoplasmic reticulum.

Involved in the control of the PYK10 complex size and possibly substrate specificity, May be exported from the endoplasmic reticulum upon interaction with MVP1

Belongs to the 'GDSL' lipolytic enzyme family


This is Acyl-acyl carrier protein thioesterase ATL3, chloroplastic protein, from Mouse-ear cress, contains 190 amino acids, locates in Plastid.

Acyl-ACP thioesterase involved in the production of fatty acids and beta-keto fatty acids, Can produce fatty acids of long chain (14:1 and 16:1) and beta-keto fatty acids of medium to long chain (8:0, 10:0, 12:0, 12:1, 14:0 and 16:0) when expressed in a heterologous organism (E,coli), Possesses thioesterase activity for lauroyl-ACP (12:0-ACP) in vitro, May play a role in the generation of long fatty acids in the chloroplast

Belongs to the 4-hydroxybenzoyl-CoA thioesterase family


This is Delta(14)-sterol reductase TM7SF2 protein, from Bovine, contains 418 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis


This is Attacin-A protein, from Savannah tsetse fly, contains 208 amino acids, is soluble, locates in Extracellular.

Hemolymph antibacterial protein against Gram-negative bacteria

Belongs to the attacin/sarcotoxin-2 family


This is Defensin-A protein, from Savannah tsetse fly, contains 87 amino acids, is soluble, locates in Extracellular.

Antibacterial peptide mostly active against Gram-positive and Gram negative bacteria

Belongs to the invertebrate defensin family, Type 1 subfamily


This is Ubiquitin domain-containing protein 2 protein, from Human, contains 234 amino acids, is soluble, locates in Cytoplasm.


This is Zinc finger protein 480 protein, from Human, contains 535 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 10 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger, locates in Nucleus.

C2H2-type 1; atypical

C2H2-type 5; degenerate

Involved in transcriptional regulation as an activator

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Pentatricopeptide repeat-containing protein 2, mitochondrial protein, from Human, contains 388 amino acids, locates in Mitochondrion.

Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function


This is Insulin-like growth factor-binding protein-like 1 protein, from Human, contains 278 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C2-type

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture, They alter the interaction of IGFs with their cell surface receptors (By similarity), May be a putative tumor suppressor protein


This is Zinc finger protein 606 protein, from Human, contains 792 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, has 13 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

C2H2-type 3; degenerate


This is Erabutoxin b protein, from Black-banded sea krait, contains 83 amino acids, is soluble, locates in Extracellular.

Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs) (tested on Torpedo marmorata, Kd=0,07 nM), and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (tested on chimeric alpha-7/CHRNA7, Kd=22 uM) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission (PubMed:7721859), Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site

Belongs to the snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily


This is Transcription factor 7-like 1-B protein, from African clawed frog, contains 551 amino acids, locates in Nucleus.

Participates in the Wnt signaling pathway, Binds to DNA and acts as a repressor in the absence of ctnnb1-A and possibly ctnnb1-B, and as an activator in the presence of these proteins, Required early in development for the establishment of the dorsal body axis in response to maternal Wnt signaling


This is Centromere protein H protein, from Chicken, contains 235 amino acids, locates in Nucleus.

Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation, Required for the localization of CENPC but not CENPA to the centromere, It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex


This is Forkhead box protein I1-A protein, from African clawed frog, contains 370 amino acids, locates in Nucleus.

Transcription factor, Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the non-neural versus neural cell fate choice, Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site


This is Nuclear receptor-binding protein 2 protein, from Mouse, contains 499 amino acids, is soluble, locates in Cytoplasm.

May regulate apoptosis of neural progenitor cells during their differentiation

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Rho guanine nucleotide exchange factor 3 protein, from Mouse, contains 524 amino acids, is soluble, locates in Cytoplasm.

Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases


This is Nuclear factor 7, brain protein, from African clawed frog, contains 609 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, locates in Nucleus.

RING-type

B box-type

Transcription factor that determines dorsal-ventral body axis


This is Ubiquitin carboxyl-terminal hydrolase 6 protein, from Fission yeast, contains 468 amino acids, locates in Nucleus.

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins, This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin

Belongs to the peptidase C19 family, USP14/UBP6 subfamily


This is Cell fusion protein cfr1 protein, from Fission yeast, contains 620 amino acids, locates in Golgi apparatus.

Required for cell fusion, independently of fus1, Appears to have a role in transporting proteins that are involved in mating, May act as a scaffold to retain cell fusion proteins in the cisternae of the Golgi, Degraded at the onset of mating and this leads to release of cell fusion proteins


This is Selenoprotein F protein, from Rat, contains 162 amino acids, is soluble, locates in Endoplasmic reticulum.

May be involved in redox reactions associated with the formation of disulfide bonds (PubMed:15659830), May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:11278576), May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity)


This is Reticulon-4-interacting protein 1, mitochondrial protein, from Mouse, contains 396 amino acids, locates in Mitochondrion.

Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267), Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236)

Belongs to the zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily


This is Mannose-6-phosphate isomerase protein, from Mouse, contains 423 amino acids, is soluble, locates in Cytoplasm.

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions

Belongs to the mannose-6-phosphate isomerase type 1 family


This is Rhombotin-1 protein, from Mouse, contains 156 amino acids, locates in Nucleus.

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors


This is Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial protein, from Caenorhabditis elegans, contains 421 amino acids, locates in Mitochondrion.

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine, Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (By similarity), Involved in mitochondrial genome maintenance


This is Small ribosomal subunit protein bS1c protein, from Mouse-ear cress, contains 416 amino acids, locates in Plastid.

Required for optimal plastid performance in terms of photosynthesis and growth, Required for the translation of plastid mRNAs (PubMed:22900828), Involved in cellular heat stress response and required for heat tolerance, Required for transcriptional activation of HSFA2 and its target genes in response to heat stress, Plays a critical role in biosynthesis of thylakoid membrane proteins encoded by chloroplast genes (PubMed:22570631)

Belongs to the bacterial ribosomal protein bS1 family


This is GDSL esterase/lipase EXL6 protein, from Mouse-ear cress, contains 343 amino acids, is soluble, locates in Extracellular.

Required for the formation of pollen coats and male fertility


This is Mitochondrial carnitine/acylcarnitine carrier-like protein protein, from Mouse-ear cress, contains 300 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in photorespiratory metabolism, Acts probably as a carrier for a glycine decarboxylase (GDC) cofactor or, alternatively, may act as a mitochondrial glycine shuttle, Involved in the transition from the embryonic stage to the juvenile autotrophic stage

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Soluble inorganic pyrophosphatase 1, chloroplastic protein, from Chlamydomonas smithii, contains 280 amino acids, locates in Plastid.


This is Formyltetrahydrofolate deformylase 1, mitochondrial protein, from Mouse-ear cress, contains 323 amino acids, locates in Mitochondrion.

Deformylase involved in photorespiration, Prevents excessive accumulation of 5-formyl tetrahydrofolate (THF), a potent inhibitor of the Gly decarboxylase/Ser hydroxymethyltransferase complex


This is Protein EXECUTER 1, chloroplastic protein, from Mouse-ear cress, contains 684 amino acids, locates in Plastid.

Together with EX2, enables higher plants to perceive singlet oxygen as a stress signal in plastid that activates a genetically determined nuclear stress response program which triggers a programmed cell death (PCD), This transfer of singlet oxygen-induced stress-related signals from the plastid to the nucleus that triggers genetically controlled PCD pathway is unique to photosynthetic eukaryotes and operates under mild stress conditions, impeding photosystem II (PSII) without causing photooxidative damage of the plant


This is Allene oxide cyclase 4, chloroplastic protein, from Mouse-ear cress, contains 254 amino acids, locates in Plastid.

Involved in the production of 12-oxo-phytodienoic acid (OPDA), a precursor of jasmonic acid

Belongs to the allene oxide cyclase family


This is Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial protein, from Mouse-ear cress, contains 476 amino acids, locates in Mitochondrion.

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family


This is Zinc finger CCCH domain-containing protein 37 protein, from Mouse-ear cress, contains 524 amino acids, has 6 C3H1-type Zinc finger, locates in Nucleus.

Involved in flower development (PubMed:11595801, PubMed:12530963), Functions in floral reproductive organ identity by binding AGAMOUS (AG) pre-mRNA and promoting its processing, Functions in association with HUA2 and HEN4 (PubMed:12530963)