This is Mediator of RNA polymerase II transcription subunit 27 protein, from Human, contains 311 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Belongs to the Mediator complex subunit 27 family


This is Sideroflexin-4 protein, from Human, contains 337 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial amino-acid transporter (By similarity), Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778)


This is Alpha-(1,3)-fucosyltransferase 10 protein, from Human, contains 479 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the transfer of fucosyl moiety from GDP-beta-L-fucose to the innermost GlcNAc residue in biantennary N-glycan acceptors, Does not fucosylate GlcNAc within type 2 lactosamine unit

Belongs to the glycosyltransferase 10 family


This is Ferredoxin-2, mitochondrial protein, from Human, contains 186 amino acids, is soluble, locates in Mitochondrion.

Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042), The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis, This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner, Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly, Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity)

Belongs to the adrenodoxin/putidaredoxin family


This is Metal transporter CNNM4 protein, from Human, contains 775 amino acids, is membrane-bound, locates in Cell membrane.

Probable metal transporter, The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity), May play a role in biomineralization and retinal function


This is RNA demethylase ALKBH5 protein, from Human, contains 394 amino acids, locates in Nucleus.

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178), Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105), Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178), Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736), Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity)


This is DNA oxidative demethylase ALKBH2 protein, from Mouse, contains 239 amino acids, locates in Nucleus.

Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation, Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA (PubMed:16174769, PubMed:16642038, PubMed:18519673), Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases, Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis (PubMed:16174769, PubMed:16642038, PubMed:18519673) (By similarity), Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine (By similarity), Acts as a gatekeeper of genomic integrity under alkylation stress, Efficiently repairs alkylated lesions in ribosomal DNA (rDNA), These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription (By similarity), In a response mechanism to DNA damage, associates with PCNA at replication forks to repair alkylated adducts prior to replication (By similarity)


This is MAGUK p55 subfamily member 4 protein, from Mouse, contains 635 amino acids, is soluble, locates in Cytoplasm.

May play a role in retinal photoreceptors development


This is Protein B-Myc protein, from Mouse, contains 170 amino acids, locates in Nucleus.

Seems to act as an inhibitor of cellular proliferation


This is Alpha- and gamma-adaptin-binding protein p34 protein, from Human, contains 315 amino acids, is soluble, locates in Cytoplasm.

May be involved in endocytic recycling of growth factor receptors such as EGFR


This is Male-specific lethal 1 homolog protein, from Mouse, contains 616 amino acids, locates in Nucleus.

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:24913909), Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) (By similarity), This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity), In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:21217699), Isoform 2, isoform 3, isoform 4 and isoform 5 can medite histone H4 acetylation at 'Lys-16' (H4K16ac) (PubMed:24913909)


This is E3 ubiquitin-protein ligase Rnf220 protein, from Mouse, contains 566 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (PubMed:20170641), Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity), Plays a critical role in the regulation of nuclear lamina


This is Stomatin-like protein 3 protein, from Mouse, contains 287 amino acids, is membrane-bound, locates in Cell membrane.

Required for the function of many mechanoreceptors, Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins, Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations


This is Transmembrane protein 88 protein, from Human, contains 159 amino acids, is membrane-bound, locates in Cell membrane.

Inhibits the Wnt/beta-catenin signaling pathway, Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development


This is Oligodendrocyte transcription factor 3 protein, from Mouse, contains 273 amino acids, locates in Nucleus.

May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons


This is N-alpha-acetyltransferase 50 protein, from Mouse, contains 169 amino acids, is soluble, locates in Cytoplasm.

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity), Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity), Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity), Autoacetylates in vivo (By similarity), The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (By similarity), Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (By similarity), Does not influence the acetyltransferase activity of NAA10 (By similarity), However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (By similarity), The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (By similarity), Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (By similarity)

Belongs to the acetyltransferase family, GNAT subfamily


This is Erythroferrone protein, from Mouse, contains 340 amino acids, is soluble, locates in Extracellular.

Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340), Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773)

Belongs to the adipolin/erythroferrone family


This is Serine/threonine-protein kinase DCLK2 protein, from Mouse, contains 756 amino acids, is soluble, locates in Cytoplasm.

Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family, May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily


This is N-alpha-acetyltransferase 35, NatC auxiliary subunit protein, from Mouse, contains 725 amino acids, is soluble, locates in Cytoplasm.

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues, Involved in regulation of apoptosis and proliferation of smooth muscle cells


This is Iodotyrosine deiodinase 1 protein, from Human, contains 289 amino acids, is membrane-bound, locates in Cell membrane.

Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283), During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651), The scavanged iodide can then reenter the hormone-producing pathways (PubMed:15289438, PubMed:18434651), Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438)


This is Aspartate--tRNA ligase, mitochondrial protein, from Human, contains 645 amino acids, is soluble, locates in Mitochondrion.

Belongs to the class-II aminoacyl-tRNA synthetase family, Type 1 subfamily


This is Transmembrane protein 65 protein, from Human, contains 240 amino acids, is membrane-bound, locates in Cell membrane.

May play an important role in cardiac development and function, May regulate cardiac conduction and the function of the gap junction protein GJA1, May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity), May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance (PubMed:28295037)


This is INO80 complex subunit C protein, from Human, contains 192 amino acids, locates in Nucleus.

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is Potassium voltage-gated channel subfamily V member 1 protein, from Human, contains 500 amino acids, is membrane-bound, locates in Cell membrane.

Potassium channel subunit that does not form functional channels by itself, Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation, Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes

Belongs to the potassium channel family, V (TC 1,A,1,2) subfamily, Kv8,1/KCNV1 sub-subfamily


This is Proton-coupled zinc antiporter SLC30A9, mitochondrial protein, from Human, contains 568 amino acids, is membrane-bound, locates in Nucleus.

Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (PubMed:28334855, PubMed:34397090, PubMed:35614220, PubMed:34433664), In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes, Plays a role in transcriptional activation of Wnt-responsive genes (By similarity)

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is Cementoblastoma-derived protein 1 protein, from Human, contains 247 amino acids, is soluble, locates in Cytoplasm.

May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469), Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626), Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628)


This is Phospholipase A2 phaiodactylipin protein, from Mafia scorpion, contains 157 amino acids, is soluble, locates in Extracellular.

Scorpion venom phospholipase A2 (PLA2) that is lethal to crickets and crustaceae, Causes inflammation in mice and lysis of human erythrocytes, Has a mild anticoagulant effect on human platelets, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group III subfamily


This is Peptidyl-prolyl cis-trans isomerase CYP59 protein, from Mouse-ear cress, contains 506 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Influences somehow regulation of RNA pol II (CTD) phosphorylation, Binds RNA with preferences for GC-rich sequences, Probably involved in activities connecting transcription and pre-mRNA processing, Involved in brassinostroid response

Belongs to the cyclophilin-type PPIase family


This is H/ACA ribonucleoprotein complex subunit NOP10 protein, from Baker's yeast, contains 58 amino acids, locates in Nucleus.

Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512), This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512), Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512), The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909), The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909), Essential for growth (PubMed:9843512)


This is Inactive dipeptidyl peptidase 10 protein, from Rat, contains 796 amino acids, is membrane-bound, locates in Cell membrane.

Promotes cell surface expression of the potassium channel KCND2, Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:16123112, PubMed:19901547), Has no dipeptidyl aminopeptidase activity (Probable)

Belongs to the peptidase S9B family, DPPIV subfamily


This is Histone-lysine N-methyltransferase KMT5C protein, from Mouse, contains 468 amino acids, locates in Nucleus.

Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:15145825, PubMed:28114273), In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity), H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825), Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825), KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:15750587, PubMed:16612004), Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity), May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily


This is Apolipoprotein A-V protein, from Human, contains 366 amino acids, is soluble, locates in Extracellular.

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL, May also be associated with chylomicrons, Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity), Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages, Binds heparin (PubMed:17326667)

Belongs to the apolipoprotein A1/A4/E family


This is 11-beta-hydroxysteroid dehydrogenase 1 protein, from Guinea pig, contains 300 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:10699594, PubMed:19507261), Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity), Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids, It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates, Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity), Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (By similarity), 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity), Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity), Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is C-type lectin domain family 7 member A protein, from Mouse, contains 244 amino acids, is membrane-bound, locates in Cell membrane.

Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11544516, PubMed:17159984, PubMed:15213161), Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:12719479, PubMed:15731053, PubMed:16825490, PubMed:32358020), Enhances cytokine production in macrophages and dendritic cells (PubMed:15845454), Mediates production of reactive oxygen species in the cell (PubMed:12719479, PubMed:15731053, PubMed:16825490), Mediates phagocytosis of C,albicans conidia (PubMed:15729357, PubMed:16825490), Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation (PubMed:10779524), Stimulates T-cell proliferation (PubMed:10779524), Induces phosphorylation of SCIMP after binding beta-glucans (PubMed:27288407)


This is Adhesion G-protein coupled receptor D1 protein, from Human, contains 874 amino acids, is membrane-bound, locates in Cell membrane.

Orphan receptor, Signals via G(s)-alpha family of G-proteins (PubMed:22025619, PubMed:22575658), Has protumorigenic function especially in glioblastoma (PubMed:27775701)

Belongs to the G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily


This is Biogenesis of lysosome-related organelles complex 1 subunit 2 protein, from Human, contains 142 amino acids, is soluble, locates in Cytoplasm.

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842), In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals, The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity), As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery, Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167), May play a role in cell proliferation (PubMed:15381421)


This is Protein LHY protein, from Mouse-ear cress, contains 645 amino acids, locates in Nucleus.

Transcription factor involved in the circadian clock, Binds to the promoter region of APRR1/TOC1 and TCP21/CHE to repress their transcription, Represses both CCA1 and itself, May recognize the promoter of JMJ14 to regulates its expression during the night in a circadian manner (PubMed:31429787)


This is 11-beta-hydroxysteroid dehydrogenase 1 protein, from Golden hamster, contains 292 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:14973125), Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity), Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (By similarity), It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates (PubMed:14973125, PubMed:9632680), Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity), Catalyzes reversibly the conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol and 7-alpha-hhydroxycholesterol metabolites (PubMed:14973125, PubMed:9632680), 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity), Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity), Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity)


This is Relaxin receptor 1 protein, from Rat, contains 758 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for relaxins, The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP, Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity)

Belongs to the G-protein coupled receptor 1 family


This is WD repeat-containing protein 74 protein, from Human, contains 385 amino acids, locates in Nucleus.

Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit (PubMed:26456651), Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (PubMed:29107693), Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development (By similarity)


This is Double homeobox protein 4C protein, from Human, contains 374 amino acids, locates in Nucleus.

May be involved in transcriptional regulation (By similarity), Down-regulates MYOD1 expression and may up-regulate MYF5 expression, May regulate microRNA (miRNA) transcription, up-regulating the expression of some myogenic miRNAs, including MIR1-1, MIR133A2, MIR133B and MIR206, Impairs the differentiation of myoblasts and may be involved in muscle regeneration


This is Constitutive coactivator of peroxisome proliferator-activated receptor gamma protein, from Mouse, contains 786 amino acids, locates in Nucleus.

Functions as a transactivator of PPARG and ESR1, Functions in adipogenesis through PPARG activation

Belongs to the constitutive coactivator of PPAR-gamma family


This is Zinc finger protein JAGGED protein, from Mouse-ear cress, contains 253 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Controls the morphogenesis of lateral organs, Functions in lateral organ shape and is sufficient to induce proliferation and growth of lateral organ tissue, Is necessary and sufficient for bract formation, but its expression is excluded from the cryptic bract, which could be a cause of bractless flowers in Arabidopsis, Participates with FIL and YAB3 in regulating valve margin development, Functions with JGL to define stamen and carpel shape, Functions with AS1 and AS2 in the sepal and petal primordia to repress boundary-specifying genes for normal development of the organs


This is SHC-transforming protein 4 protein, from Mouse, contains 626 amino acids, is membrane-bound, locates in Cell membrane.

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas, Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1


This is Transcription factor E2F7 protein, from Mouse, contains 904 amino acids, locates in Nucleus.

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response, Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3', Directly represses transcription of classical E2F transcription factors such as E2F1, Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes, Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3), Required for placental development by promoting polyploidization of trophoblast giant cells, Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication, Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene, Acts as a negative regulator of keratinocyte differentiation


This is Fe-S cluster assembly factor HCF101, chloroplastic protein, from Mouse-ear cress, contains 532 amino acids, is soluble, locates in Plastid.

Required for photosystem I (PSI) biosynthesis and assembly, May serve as a chloroplast scaffold protein that specifically assembles iron-sulfur (4Fe-4S) clusters and transfers them to the chloroplast PSI and ferredoxin-thioredoxin (FTR) complexes, Can assemble a 4Fe-4S cluster and transfer it to apoproteins in yeast cells, Probably not required for assembly or stability of plastidic 2Fe-2S clusters

Belongs to the Mrp/NBP35 ATP-binding proteins family


This is Stearoyl-CoA desaturase 4 protein, from Mouse, contains 353 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates, Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:12815040, PubMed:16443825), Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)

Belongs to the fatty acid desaturase type 1 family


This is Carotene epsilon-monooxygenase, chloroplastic protein, from Mouse-ear cress, contains 539 amino acids, is membrane-bound, locates in Plastid.

Heme-containing cytochrome P450 involved in the biosynthesis of xanthophylls, Specific for epsilon- and beta-ring hydroxylation of alpha-carotene, Has only a low activity toward the beta-rings of beta-carotene, The preferred substrate in planta is not alpha-carotene but the epsilon-ring of zeinoxanthin (PubMed:12782726, PubMed:16890225, PubMed:19147649, PubMed:19939422), Possesses a major beta-carotene hydroxylase activity in planta when depleted in its preferred substrate alpha-carotene (PubMed:22513258)


This is Progestin and adipoQ receptor family member 3 protein, from Human, contains 311 amino acids, is membrane-bound, locates in Golgi apparatus.

Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi


This is Vitamin K epoxide reductase complex subunit 1 protein, from Rat, contains 161 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vitamin K metabolism, Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K, Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development


This is Vitamin K epoxide reductase complex subunit 1-like protein 1 protein, from Mouse, contains 176 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vitamin K metabolism, Can reduce inactive vitamin K 2,3-epoxide to active vitamin K, and may contribute to vitamin K-mediated protection against oxidative stress, Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins


This is E3 ubiquitin-protein ligase MYLIP-A protein, from Zebrafish, contains 472 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity), Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway


This is Methionine aminopeptidase 1D, mitochondrial protein, from Human, contains 335 amino acids, locates in Mitochondrion.

Removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val), Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity), May play a role in colon tumorigenesis

Belongs to the peptidase M24A family, Methionine aminopeptidase type 1 subfamily


This is Monofunctional C1-tetrahydrofolate synthase, mitochondrial protein, from Human, contains 978 amino acids, locates in Mitochondrion.

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2

In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family


This is Aftiphilin protein, from Human, contains 936 amino acids, is soluble, locates in Cytoplasm.

Component of clathrin-coated vesicles (PubMed:15758025), Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025)


This is Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial protein, from Rat, contains 616 amino acids, is membrane-bound, locates in Mitochondrion.

Accepts electrons from ETF and reduces ubiquinone


This is C-type lectin domain family 2 member A protein, from Human, contains 174 amino acids, is membrane-bound, locates in Cell membrane.

Plays a role in modulating the extent of T-cell expansion, Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins, May modulate the capacity of T-cells to home to lymph nodes through SELL, Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity


This is E3 ubiquitin-protein ligase LRSAM1 protein, from Human, contains 723 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501), Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322), Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098)


This is Protein GPR15LG protein, from Human, contains 81 amino acids, is soluble, locates in Extracellular.

Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec,, and Mycoplasma hominis and lentivirus (PubMed:25585381)


This is Lysocardiolipin acyltransferase 1 protein, from Human, contains 414 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity), Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity), Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771), Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029), Required for establishment of the hematopoietic and endothelial lineages (By similarity)

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is Glycerophosphocholine cholinephosphodiesterase ENPP6 protein, from Human, contains 440 amino acids, is membrane-bound, locates in Cell membrane.

Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404), Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids, In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity)

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family


This is BRCA1-A complex subunit Abraxas 1 protein, from Human, contains 409 amino acids, locates in Nucleus.

Involved in DNA damage response and double-strand break (DSB) repair, Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1, The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs, This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX

Belongs to the FAM175 family, Abraxas subfamily


This is Protein LMBR1L protein, from Human, contains 489 amino acids, is membrane-bound, locates in Cell membrane.

Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity), In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity), LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity), Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685)


This is Angiopoietin-like protein 8 protein, from Human, contains 198 amino acids, is soluble, locates in Extracellular.

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577), May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity)


This is WD repeat-containing protein 82 protein, from Human, contains 313 amino acids, locates in Nucleus.

Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes (PubMed:17998332, PubMed:18838538, PubMed:20516061), Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) (PubMed:17998332, PubMed:18838538), Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061), Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452), The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs and promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33767452)


This is MICOS complex subunit MIC27 protein, from Human, contains 268 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane, Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol, Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979)

Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family


This is CMRF35-like molecule 5 protein, from Human, contains 194 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type


This is Dipeptidyl peptidase 8 protein, from Human, contains 898 amino acids, is soluble, locates in Cytoplasm.

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:11012666, PubMed:12534281, PubMed:12662155, PubMed:15039077, PubMed:15664838, PubMed:20536396, PubMed:29382749), Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:32796818), Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:34019797, PubMed:33731929, PubMed:33731932), The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (By similarity)


This is Transcription factor AP-2-epsilon protein, from Mouse, contains 442 amino acids, locates in Nucleus.

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes, AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development, They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC, AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation


This is Potassium channel subfamily K member 18 protein, from Mouse, contains 394 amino acids, is membrane-bound, locates in Cell membrane.

Outward rectifying potassium channel, Produces rapidly activating outward rectifier K(+) currents, May function as background potassium channel that sets the resting membrane potential, Channel activity is directly activated by calcium signal, Activated by the G(q)-protein coupled receptor pathway, The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation, Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids, Channel activity is also enhanced by volatile anesthetics, such as isoflurane, Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper, May be involved in the somatosensory function with special respect to pain sensation

Belongs to the two pore domain potassium channel (TC 1,A,1,8) family


This is Aspartic proteinase CDR1 protein, from Mouse-ear cress, contains 437 amino acids, is soluble, locates in Extracellular.

Involved in salicylic acid-dependent inducible resistance responses, May release an endogenous peptide elicitor required for the activation of inducible resistance mechanisms, Possesses protease activity in vitro


This is Zinc finger protein GLIS3 protein, from Mouse, contains 780 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

Acts as both a repressor and activator of transcription, Binds to the consensus sequence 5'-GACCACCCAC-3'

Belongs to the GLI C2H2-type zinc-finger protein family


This is Nicotinate phosphoribosyltransferase protein, from Human, contains 538 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198), Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275)


This is Cytochrome P450 2C54 protein, from Mouse, contains 490 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE)


This is Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 protein, from Human, contains 254 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction), This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle, This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation, Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators

Belongs to the very long-chain fatty acids dehydratase HACD family


This is Beta-1,3-glucosyltransferase protein, from Human, contains 498 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage, Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan

Belongs to the glycosyltransferase 31 family


This is Hydroxysteroid dehydrogenase-like protein 2 protein, from Human, contains 418 amino acids, locates in Peroxisome.

Has apparently no steroid dehydrogenase activity


This is Transcription factor TDR protein, from Rice, contains 552 amino acids, locates in Nucleus.

Transcription factor involved in the regulation of tapetum programmed cell death (PCD) and degradation during male reproductive development, Promotes tapetal PCD, Positively regulates the expression of two tapetum-specific genes, the cysteine protease CP1 and the lipid-transfer protein C6 (PubMed:17138695), Acts upstream from and interacts with EAT1/DTD in the regulation of tapetal PCD (PubMed:23385589), Regulates the expression of genes related to aliphatic metabolism during pollen development, May play regulatory role in the lipidic metabolism involved in the formation of pollen wall (PubMed:19825565)


This is Transcription factor ILI5 protein, from Rice, contains 88 amino acids, locates in Nucleus.

Atypical and probable non DNA-binding bHLH transcription factor that acts as a positive regulator of grain size (PubMed:23136524), Involved in the brassinosteroid (BR) signaling pathway (PubMed:27879391), Binds the transcription repressor APG and forms a heterodimer of antagonistic basic helix-loop-helix transcription factors that regulates grain length and weight by controlling cell elongation in lemma and palea (PubMed:23136524), Contributes, together with LO9-177 and BC1, to the promotion of leaf inclination and grain size by modulating cell elongation (PubMed:27879391)


This is Bidirectional sugar transporter SWEET11 protein, from Rice, contains 307 amino acids, is membrane-bound, locates in Cell membrane.

Confers sensitivity to bacterial blight mediated by X,oryzae pv, oryzae (Xoo) in its Xa13 allelic form (e,g, cv, IR24), probably by providing the sugar required for the pathogen growth, or by reducing copper contents in xylem, However, a recessive resistance can be associated with the xa13 allele (in which the promoter is mutated leading to reduced induction upon pathogen infection, e,g, cv, IRBB13), specifically toward Xoo Philippine race 6 and Indian race PXO8

Belongs to the SWEET sugar transporter family


This is SPX domain-containing protein 2 protein, from Rice, contains 280 amino acids, locates in Nucleus.

Inhibits PHR2 DNA-binding activity via a phosphate (Pi)-dependent protein interaction (PubMed:25271318), Together with SPX1, plays a negative role in the regulation of leaf inclination by preventing RLI1 transcription factor activity in Pi depleted conditions (PubMed:29610209)


This is 12-oxophytodienoate reductase 7 protein, from Rice, contains 394 amino acids, locates in Peroxisome.

Involved in the biosynthesis of jasmonate (JA) and perhaps in biosynthesis or metabolism of other oxylipin signaling moleclules (PubMed:17938955, PubMed:29177846), In vitro, reduces cis(+)-12-oxophytodienoic acid (cis(+)-OPDA) and cis(-)-OPDA to cis(+)-OPC-8:0 and cis(-)-OPC-8:0, respectively (PubMed:17938955), May be required for the spatial and temporal regulation of JA levels during dehiscence of anthers, promoting the stomium degeneration program (PubMed:17938955), Involved in carbohydrate transport underlying normal lodicule function during anthesis (PubMed:29177846)

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family


This is Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase protein, from Human, contains 384 amino acids, is membrane-bound, locates in Golgi apparatus.

Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins, Plays an important role in the synthesis of mucin-type O-glycans in digestive organs


This is Interleukin-34 protein, from Human, contains 242 amino acids, is soluble, locates in Extracellular.

Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages, Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption, Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1


This is ADAMTS-like protein 5 protein, from Human, contains 481 amino acids, is soluble, locates in Extracellular.

May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM)


This is RNA-binding protein MEX3B protein, from Human, contains 569 amino acids, has 1 RING-type Zinc finger, locates in Cytoplasm.

RING-type

RNA-binding protein, May be involved in post-transcriptional regulatory mechanisms


This is Alkylglycerol monooxygenase protein, from Human, contains 445 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids, Ether lipids are essential components of brain membranes

Belongs to the sterol desaturase family, TMEM195 subfamily


This is PHD finger protein 21A protein, from Mouse, contains 688 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells, The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier, In the BHC complex, it may act as a scaffold, Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity)


This is Nuclear envelope integral membrane protein 1 protein, from Mouse, contains 437 amino acids, is membrane-bound, locates in Nucleus.

Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640), Required for female fertility (PubMed:32923640)


This is Monocarboxylate transporter 12 protein, from Human, contains 516 amino acids, is membrane-bound, locates in Cell membrane.

Functions as a transporter for creatine and as well for its precursor guanidinoacetate, Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH, Contributes to the process of creatine biosynthesis and distribution

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is Cadherin-related family member 3 protein, from Human, contains 885 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Acts as a receptor for rhinovirus C


This is Septin-14 protein, from Human, contains 432 amino acids, is soluble, locates in Cytoplasm.

Filament-forming cytoskeletal GTPase (Probable), Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity), Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246)

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family


This is Cytochrome P450 4V2 protein, from Human, contains 525 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in fatty acid metabolism in the eye, Catalyzes the omega-hydroxylation of polyunsaturated fatty acids (PUFAs) docosahexaenoate (DHA) and its precursor eicosapentaenoate (EPA), and may contribute to the homeostasis of these retinal PUFAs (PubMed:22772592), Omega hydroxylates saturated fatty acids such as laurate, myristate and palmitate, the catalytic efficiency decreasing in the following order: myristate > laurate > palmitate (C14>C12>C16) (PubMed:19661213), Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)


This is Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase protein, from African clawed frog, contains 359 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (PubMed:17333390, PubMed:18095347), Glycosphingolipids are required for convergence extension movements during early development (PubMed:18095347), Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 (By similarity), Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (By similarity)

Belongs to the glycosyltransferase 29 family


This is General transcription factor IIH subunit 5 protein, from Human, contains 71 amino acids, locates in Nucleus.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription, Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell


This is Zinc finger protein JACKDAW protein, from Mouse-ear cress, contains 503 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 CCHC-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; degenerate

CCHC-type 2; atypical

Transcription factor that, together with BIB, regulates tissue boundaries and asymmetric cell division by a rapid up-regulation of 'SCARECROW' (SCR), thus controlling the nuclear localization of 'SHORT-ROOT' (SHR) and restricting its action (PubMed:17785527, PubMed:25829440), Binds DNA via its zinc fingers (PubMed:28211915, PubMed:24821766), Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766), Confines CYCD6 expression to the cortex-endodermis initial/daughter (CEI/CEID) tissues (PubMed:25829440), Required for radial patterning and stem cell maintenance (PubMed:17785527), Counteracted by 'MAGPIE' (MGP) (PubMed:17785527), Binds to the SCR and MGP promoter sequences (PubMed:21935722), Controls position-dependent signals that regulate epidermal-cell-type patterning (PubMed:20356954)


This is Acid-sensing ion channel 1C protein, from Zebrafish, contains 529 amino acids, is membrane-bound, locates in Cell membrane.

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized, Generates a biphasic current with a fast inactivating and a slow sustained phase, Has high selectivity for sodium ions and can also transport lithium ions with high efficiency, Can also transport potassium ions, but with lower efficiency, It is nearly impermeable to the larger rubidium and cesium ions

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family, ASIC1 subfamily


This is Acid-sensing ion channel 1A protein, from Zebrafish, contains 501 amino acids, is membrane-bound, locates in Cell membrane.


This is Acid-sensing ion channel 1B protein, from Zebrafish, contains 557 amino acids, is membrane-bound, locates in Cell membrane.


This is EIN3-binding F-box protein 2 protein, from Mouse-ear cress, contains 623 amino acids, locates in Nucleus.

Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1), Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins


This is Ubiquitin carboxyl-terminal hydrolase 30 protein, from Human, contains 517 amino acids, is membrane-bound, locates in Mitochondrion.

Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951), Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951), Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291), Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity)


This is Thioredoxin reductase NTRC protein, from Rice, contains 515 amino acids, locates in Plastid.

Thioredoxin reductase (TR) that exhibits both TR and thioredoxin (Trx) activities, Contains a C-terminal functional Trx domain, Functions as an electron donor for the plastidial 2-Cys peroxiredoxin BAS1 and participates in a NADPH-dependent hydrogen peroxide scavenging system in chloroplasts in the dark

Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family


This is Mitochondrial S-adenosylmethionine carrier protein protein, from Human, contains 274 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter, Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Tripeptidyl-peptidase sed2 protein, from Neosartorya fumigata, contains 602 amino acids, is soluble, locates in Extracellular.

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence


This is Peptidoglycan-recognition protein SB1 protein, from Fruit fly, contains 190 amino acids, is soluble, locates in Extracellular.

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN), preferentially DAP-type PGNs, Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family


This is Inhibitor of nuclear factor kappa-B kinase-interacting protein protein, from Human, contains 350 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Target of p53/TP53 with pro-apoptotic function


This is Protein ZNF365 protein, from Human, contains 407 amino acids, has 1 C2H2-type; degenerate Zinc finger, is soluble, locates in Cytoplasm.

C2H2-type; degenerate

Involved in the regulation of neurogenesis, Negatively regulates neurite outgrowth (PubMed:17389905), Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis, Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth, Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (By similarity), Involved in homologous recombination (HR) repair pathway, Required for proper resolution of DNA double-strand breaks (DSBs) by HR, Is required for recovery of stalled replication forks, and directly contributes to genomic stability, Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166), Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040)


This is 5-hydroxytryptamine receptor 3D protein, from Human, contains 454 amino acids, is membrane-bound, locates in Cell membrane.

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen, This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses, It is a cation-specific, but otherwise relatively nonselective, ion channel

Belongs to the ligand-gated ion channel (TC 1,A,9) family, 5-hydroxytryptamine receptor (TC 1,A,9,2) subfamily, HTR3D sub-subfamily


This is Protein FRA10AC1 protein, from Human, contains 315 amino acids, locates in Nucleus.


This is cAMP-regulated phosphoprotein 19 protein, from Rat, contains 112 amino acids, is soluble, locates in Cytoplasm.

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis, When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity), May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA


This is BTB/POZ domain-containing protein KCTD1 protein, from Human, contains 257 amino acids, locates in Nucleus.

May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent


This is Phosducin-like protein 1 protein, from Social amoeba, contains 316 amino acids, is soluble, locates in Cytoplasm.

Required for normal chemotaxis in response to cAMP and folate, Required for the heterodimerization of the G protein beta and gamma subunits gpbA and gpgA, which is itself thought to be necessary for prenylation of the gamma subunit gpgA and its association with plasma membranes


This is Delta(14)-sterol reductase TM7SF2 protein, from Mouse, contains 418 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis


This is Solute carrier organic anion transporter family member 4C1 protein, from Rat, contains 724 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney, Capable of transporting cAMP and pharmacological substances such as digoxin, ouabain and methotrexate (PubMed:14993604), Transport is independent of sodium, chloride ion, and ATP (PubMed:14993604, PubMed:22768102), Transport activity is stimulated by an acidic extracellular environment due to increased substrate affinity to the transporter (PubMed:14993604, PubMed:22768102), The driving force for this transport activity is currently not known (PubMed:22768102), The role of hydrogencarbonate (HCO3(-), bicarbonate) as the probable counteranion that exchanges for organic anions is still not well defined (PubMed:14993604, PubMed:22768102), Functions as an uptake transporter at the apical membrane, suggesting a role in renal reabsorption (PubMed:22768102), Involved in the renal secretion of the uremic toxin ADMA (N(omega),N(omega)-dimethyl-L-arginine or asymmetrical dimethylarginine), which is associated to cardiovascular events and mortality, and the structurally related amino acids L-arginine and L-homoarginine (a cardioprotective biomarker), Can act bidirectionally, suggesting a dual protective role of this transport protein; exporting L-homoarginine after being synthesized in proximal tubule cells, and mediating uptake of ADMA from the blood into proximal tubule cells where it is degraded by the enzyme dimethylarginine dimethylaminohydrolase 1 (DDAH1) (By similarity), May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells, This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation, May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg (By similarity)

Belongs to the organo anion transporter (TC 2,A,60) family


This is Mediator of RNA polymerase II transcription subunit 25 protein, from Human, contains 747 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, Required for RARA/RXRA-mediated transcription

Belongs to the Mediator complex subunit 25 family


This is Elongation factor 1-alpha 2 protein, from Rabbit, contains 463 amino acids, locates in Nucleus.

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily


This is KH domain-containing protein SPIN1 protein, from Rice, contains 281 amino acids, locates in Nucleus.

Involved in flowering time control, Binds DNA and RNA in vitro


This is Solanesyl-diphosphate synthase 2, chloroplastic protein, from Rice, contains 403 amino acids, locates in Plastid.

Involved in providing solanesyl diphosphate for plastoquinone-9 (PQ-9) formation, Geranyl diphosphate is the preferred substrate


This is E3 ubiquitin-protein ligase Hakai protein, from Human, contains 491 amino acids, has 1 RING-type Zinc finger, has 1 C2H2-type Zinc finger, is soluble, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity), Targets CDH1 for endocytosis and degradation (By similarity), Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755), Its function in the WMM complex is unknown (PubMed:29507755)


This is Metal cation symporter ZIP14 protein, from Mouse, contains 489 amino acids, is membrane-bound, locates in Cell membrane.

Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity (PubMed:15863613, PubMed:16950869, PubMed:18270315, PubMed:19179618, PubMed:21653899, PubMed:28673968), Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (PubMed:18270315), Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (PubMed:18270315), Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (PubMed:25428902), Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (PubMed:21445361), Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin (PubMed:27703010), Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (PubMed:28673968), Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake (PubMed:31028174), Also involved in manganese extracellular uptake by cells of the blood-brain barrier (By similarity), May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (PubMed:28536273), Also functions in the extracellular uptake of free iron (PubMed:16950869, PubMed:19179618, PubMed:21653899, PubMed:23110240, PubMed:26028554), May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin (PubMed:20682781), Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages (By similarity)

Belongs to the ZIP transporter (TC 2,A,5) family


This is Mitochondrial import receptor subunit TOM70 protein, from Rat, contains 610 amino acids, is membrane-bound, locates in Mitochondrion.

Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex), Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:11956321, PubMed:19401463), Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (By similarity)


This is Dual specificity protein phosphatase PHS1 protein, from Mouse-ear cress, contains 929 amino acids, is soluble, locates in Cytoplasm.

Probable dual specificity phosphatase that binds and dephosphorylates MPK18, modulating the organization and dynamics of cortical microtubules, Acts as negative regulator of abscisic acid (ABA) signaling during seed germination and light-induced stomata aperture


This is GPI inositol-deacylase protein, from Rat, contains 922 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in inositol deacylation of GPI-anchored proteins, GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi

Belongs to the GPI inositol-deacylase family


This is Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B protein, from Mouse, contains 792 amino acids, is membrane-bound, locates in Golgi apparatus.

Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans, Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan (By similarity), Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan (PubMed:22715095), Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway

Belongs to the glycosyltransferase 18 family


This is Solanesyl diphosphate synthase 2, chloroplastic protein, from Mouse-ear cress, contains 417 amino acids, locates in Plastid.

Involved in providing solanesyl diphosphate for plastoquinone-9 (PQ-9) formation in plastids (PubMed:15784989, PubMed:23913686) (Probable), Catalyzes the elongation of the prenyl side chain of PQ-9 in plastids (PubMed:23913686), Contributes to the biosynthesis of plastochromanol-8 (PC-8) in plastids (PubMed:23913686), Does not contribute to the synthesis of tocopherol or ubiquinone (PubMed:23913686), PQ-9 and PC-8 are lipophilic antioxidants that act as protectant against photooxidative stress under high light stress conditions (PubMed:23913686), Prefers geranylgeranyl diphosphate to farnesyl diphosphate as substrate (PubMed:15784989), No activity with geranyl diphosphate or dimethylallyl diphosphate as substrate (PubMed:15784989)


This is Free fatty acid receptor 1 protein, from Mouse, contains 300 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis, Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1), May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (PubMed:23335512), Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration, Seems to act through a G(q) and G(i)-mediated pathway, Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation

Belongs to the G-protein coupled receptor 1 family


This is DNA-directed RNA polymerase I subunit RPA34 protein, from Mouse, contains 399 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I which synthesizes ribosomal RNA precursors, Involved in UBTF-activated transcription, presumably at a step following PIC formation

Belongs to the eukaryotic RPA34 RNA polymerase subunit family


This is Serine/threonine-protein kinase/endoribonuclease IRE2 protein, from Human, contains 926 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress, Pro-apoptotic, Appears to play no role in the unfolded-protein response, unlike closely related proteins

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Centrosomal protein of 68 kDa protein, from Human, contains 757 amino acids, is soluble, locates in Cytoplasm.

Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621), Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564), Contributes to CROCC/rootletin filament formation (PubMed:30404835)


This is Methionine-R-sulfoxide reductase B2, mitochondrial protein, from Mouse, contains 175 amino acids, locates in Mitochondrion.

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine, While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue, Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance

Belongs to the MsrB Met sulfoxide reductase family


This is F-box only protein 22 protein, from Mouse, contains 402 amino acids, is soluble, locates in Cytoplasm.

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function


This is Enoyl-CoA delta isomerase 3, peroxisomal protein, from Mouse, contains 317 amino acids, locates in Peroxisome.

Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA (PubMed:24344334), May also have activity towards other enoyl-CoA species (Probable)

Belongs to the enoyl-CoA hydratase/isomerase family


This is Dynein light chain 2, cytoplasmic protein, from Rat, contains 89 amino acids, is soluble, locates in Cytoplasm.

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function, Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules, May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)

Belongs to the dynein light chain family


This is DnaJ homolog subfamily C member 15 protein, from Mouse, contains 149 amino acids, is membrane-bound, locates in Mitochondrion.

Acts as an import component of the TIM23 translocase complex, Stimulates the ATPase activity of HSPA9 (By similarity), Negative regulator of the mitochondrial respiratory chain, Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP


This is DELLA protein SLR1 protein, from Rice, contains 625 amino acids, locates in Nucleus.

Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway, Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes, Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway, In contrast, its overexpression prevents the GA signaling pathway and induces a dwarf phenotype

Belongs to the GRAS family, DELLA subfamily


This is Two-component response regulator ARR15 protein, from Mouse-ear cress, contains 206 amino acids, locates in Nucleus.

Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system, Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes, Type-A response regulators seem to act as negative regulators of the cytokinin signaling

Belongs to the ARR family, Type-A subfamily


This is Bromodomain-containing protein 2 protein, from Mouse, contains 798 amino acids, locates in Nucleus.

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling, Regulates transcription of the CCND1 gene, Plays a role in nucleosome assembly (By similarity), May play a role in spermatogenesis or folliculogenesis


This is Protein teflon protein, from Fruit fly, contains 649 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Specifically required in males for proper segregation of autosomal bivalents at meiosis I, Expression is required in the male germ line prior to spermatocyte stage S4, May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections


This is Sodium-dependent dopamine transporter protein, from Fruit fly, contains 631 amino acids, is membrane-bound, locates in Cell membrane.

Sodium-dependent dopamine transporter which terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:11125028, PubMed:12606774, PubMed:24037379, PubMed:25970245), Also transports tyramine and norepinephrine, shows less efficient transport of octopamine and does not transport serotonin (PubMed:11125028, PubMed:12606774), Plays a role in the regulation of the rest/activity cycle (PubMed:16093388, PubMed:25232310)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family


This is Polyadenylate-binding protein 2 protein, from Fruit fly, contains 224 amino acids, locates in Cytoplasm.

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (PubMed:10481015), Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity), Increases the affinity of poly(A) polymerase for RNA (By similarity), Binds to poly(A) and to poly(G) with high affinity (PubMed:10481015), May protect the poly(A) tail from degradation (By similarity), Plays a role in the positive regulation of alpha-1,3 fucosylation, possibly by cooperating with swm which regulates nuclear export of fucosyltransferase FucTA (PubMed:21203496)


This is Longitudinals lacking protein, isoforms A/B/D/L protein, from Fruit fly, contains 787 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is Transcriptional adapter 2A protein, from Fruit fly, contains 562 amino acids, has 1 ZZ-type Zinc finger, locates in Nucleus.

ZZ-type

GCN5-independent Rpb4 complexes are highly enriched in decondensed chromosome puffs so may play a role in RNA polymerase II-dependent transcription


This is Cytochrome c oxidase assembly protein COX15 homolog protein, from Human, contains 410 amino acids, is membrane-bound, locates in Mitochondrion.

May be involved in the biosynthesis of heme A


This is Cytochrome b5 reductase 4 protein, from Human, contains 521 amino acids, locates in Endoplasmic reticulum.

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway, Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS), Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family


This is Centromere protein Q protein, from Human, contains 268 amino acids, locates in Nucleus.

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation, May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420), Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579)


This is Hsp90 co-chaperone Cdc37-like 1 protein, from Human, contains 337 amino acids, is soluble, locates in Cytoplasm.

Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90


This is Protein Bop protein, from Human, contains 364 amino acids, locates in Mitochondrion.

Could induce apoptosis in a BH3 domain-dependent manner, The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity


This is Mitoguardin 2 protein, from Human, contains 593 amino acids, is membrane-bound, locates in Mitochondrion.

Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers, May act by regulating phospholipid metabolism via PLD6/MitoPLD


This is Protein MCM10 homolog protein, from Human, contains 875 amino acids, locates in Nucleus.

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication, Additionally, plays a role in preventing DNA damage during replication, Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359)


This is Protein arginine methyltransferase NDUFAF7, mitochondrial protein, from Human, contains 441 amino acids, locates in Mitochondrion.

Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:20406883, PubMed:24089531, PubMed:24838397), Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex (PubMed:24089531)


This is Golgi to ER traffic protein 4 homolog protein, from Human, contains 327 amino acids, is soluble, locates in Cytoplasm.

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892, PubMed:32395830), The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane, Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373), Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892), Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475), The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome, It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303)


This is Mitochondrial enolase superfamily member 1 protein, from Human, contains 443 amino acids, locates in Mitochondrion.

Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins, Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329)

Belongs to the mandelate racemase/muconate lactonizing enzyme family, ENOSF1 subfamily


This is G2/M phase-specific E3 ubiquitin-protein ligase protein, from Human, contains 706 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 2 PHD-type Zinc finger, has 1 PHD-type 2; degenerate Zinc finger, locates in Cytoplasm.

C2HC pre-PHD-type

PHD-type

PHD-type 2; degenerate

PHD-type

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Essential in early embryonic development to prevent apoptotic death


This is EPM2A-interacting protein 1 protein, from Human, contains 607 amino acids, locates in Endoplasmic reticulum.


This is Tubulinyl-Tyr carboxypeptidase 1 protein, from Human, contains 365 amino acids, is soluble, locates in Extracellular.

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31270470, PubMed:31235910, PubMed:31171830, PubMed:31235911), Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830), Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325), This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096)

Belongs to the transglutaminase-like superfamily, Vasohibin family


This is FAST kinase domain-containing protein 5, mitochondrial protein, from Human, contains 764 amino acids, is soluble, locates in Mitochondrion.

Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715)


This is 11-beta-hydroxysteroid dehydrogenase 1 protein, from Rabbit, contains 292 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Controls the reversible conversion of biologically active glucocorticoids such as cortisone to cortisol, and 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:7836463, PubMed:19456256), Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity), Plays a role in the secretion of aqueous humor in the eye, maintaining a normotensive, intraocular environment (By similarity), Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (By similarity), It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates, It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates, Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity), Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (By similarity), 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity), Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity), Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Transcription factor castor protein, from Fruit fly, contains 793 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 3 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; atypical

Transcription factor that specifies expression of key genes in developing central nervous system (CNS), Essential for many, if not all, late developing neuroblastoma (NB) sublineages, Binds to the 5'-[CG]C[CT][CT]AAAAA[AT]-3' DNA sequence, like hb, suggesting that cas and hb act as a late regulators in early and late CNS NB sublineage, respectively, Acts by repressing expression of nub/pdm-1 and pdm2/pdm-2 POU genes, and restrict their pattern of expression in appropriate cells, Required for a full expression of vvl/drifter and acj6/I-POU; it is however unknown whether it directly activates these genes, Controls engrailed (en) expression in the ventral nerve chord


This is Transcription factor SOX-11 protein, from Mouse, contains 395 amino acids, locates in Nucleus.

Transcription factor that acts as a transcriptional activator (PubMed:18505825, PubMed:18403418), Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18505825, PubMed:18403418), Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (PubMed:20596238), Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238)


This is Sodium channel subunit beta-4 protein, from Rat, contains 228 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Modulates channel gating kinetics, Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation, Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom

Belongs to the sodium channel auxiliary subunit SCN4B (TC 8,A,17) family


This is Opalin protein, from Mouse, contains 143 amino acids, is membrane-bound, locates in Cell membrane.

Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation, Promotes oligodendrocyte terminal differentiation


This is Protein argonaute-3 protein, from Fruit fly, contains 867 amino acids, is soluble, locates in Cytoplasm.

Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements, Associates predominantly with sense piRNAs that contain adenine at nucleotide 10, but shows no preference for uridine at the 5' end, In testis, however, associates with Su(Ste) and AT-chX-1 piRNAs mostly produced from antisense precursors, Shows RNA cleavage activity, In the germline, acts to amplify pools of antisense piRNAs, among others Su(Ste), AT-chX-1 and roo, and to limit sense piRNA accumulation, Forms a complex with smg, twin, aub and specific piRNAs that targets nos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis, Involved in transposon silencing in the adult brain

Belongs to the argonaute family, Piwi subfamily