This is Transcription factor fos-1 protein, from Caenorhabditis elegans, contains 467 amino acids, locates in Nucleus.

Required for ovulation (PubMed:19570917), Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917), Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 (PubMed:23437011)

Belongs to the bZIP family, Fos subfamily


This is Transcription factor jun-1 protein, from Caenorhabditis elegans, contains 319 amino acids, locates in Nucleus.

Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3' (PubMed:17942488), Required for ovulation (PubMed:19570917), Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation (PubMed:19570917)

Belongs to the bZIP family, Jun subfamily


This is Non-specific lipid-transfer protein-like 2 protein, from Caenorhabditis elegans, contains 412 amino acids, locates in Peroxisome.

Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA (PubMed:9151950), Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone (PubMed:19496754, PubMed:19174521)

Belongs to the thiolase-like superfamily, Thiolase family


This is Serine/threonine-protein kinase nekl-3 protein, from Caenorhabditis elegans, contains 302 amino acids, is soluble, locates in Cytoplasm.

Probable serine/threonine-protein kinase required for the completion of molting

Belongs to the protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily


This is Vacuolar protein sorting-associated protein 52 homolog protein, from Caenorhabditis elegans, contains 702 amino acids, locates in Golgi apparatus.

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545), The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545), Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843), Important for neuronal function (PubMed:27191843)


This is Betaine receptor acr-23 protein, from Caenorhabditis elegans, contains 545 amino acids, is membrane-bound, locates in Cell membrane.

Betaine receptor that functions as a ligand-gated non-selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion, The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions, Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily


This is Hypoxia-inducible factor 1 protein, from Caenorhabditis elegans, contains 719 amino acids, locates in Nucleus.

A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size (PubMed:11427734, PubMed:12006646, PubMed:12686697, PubMed:15781453, PubMed:18477695, PubMed:19461873, PubMed:21093262, PubMed:19889840, PubMed:20520707, PubMed:20400959), Involved in mediating susceptibility to enteropathogenic E,coli (PubMed:16091039), Increased levels of hif-1 activity confer resistance to P,aeruginosa-mediated death but also confer susceptibility to S,aureus infection (PubMed:20865124, PubMed:22792069), Required for aha-1 nuclear localization (PubMed:11427734), Following hypoxic stress, up-regulates serotonin levels through activation of tph-1 expression (PubMed:20400959), Role in life span extension is dependent of temperature (PubMed:21241450), Not required for survival in anoxic conditions (PubMed:11427734), Involved in iron homeostasis by repressing transcription of ferritin ftn-1 and ftn-2, and divalent metal transporter smf-3 (PubMed:22396654, PubMed:22194696), May be involved in manganese homeostasis by repressing divalent metal transporter smf-3 (PubMed:22194696)


This is Cell fusion protein aff-1 protein, from Caenorhabditis elegans, contains 589 amino acids, is membrane-bound, locates in Cell membrane.

Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells (PubMed:17488621), Required for amphid sheath cell fusion induced by entry into dauer stage (PubMed:21350017)

Belongs to the EFF/AFF cell fusogen family


This is Inactive tyrosine-protein kinase RYK protein, from Caenorhabditis elegans, contains 583 amino acids, is membrane-bound, locates in Cell membrane.

Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity), Receptor which may act as a receptor for Wnt ligand mom-2, Plays a role in controlling P7,p vulva precursor cell lineage orientation during vulva development (PubMed:15369677, PubMed:15649465), Regulates pop-1 asymmetric distribution in P7,p and its daughter cells (PubMed:15649465), Plays a role in the migration of ALM neurons during embryogenesis (PubMed:18622031)

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is Ankyrin repeat and LEM domain-containing protein 2 homolog protein, from Caenorhabditis elegans, contains 603 amino acids, is membrane-bound, locates in Nucleus.

Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit, Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly, It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex


This is Endo-1,4-beta-xylanase B protein, from Wheat head blight fungus, contains 228 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Plays an important role in causing fusarium head blight (FHB) on cereal crops, Induces cell death and hydrogen peroxide accumulation in infected wheat leaves

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is Tuliposide A-converting enzyme 1, chloroplastic protein, from Garden tulip, contains 385 amino acids, locates in Plastid.

Lactone-forming carboxylesterases, specifically catalyzing intramolecular transesterification, but not hydrolysis, Involved in the biosynthesis of tulipalins, defensive chemicals that show antimicrobial activities against a broad range of strains of bacteria and fungi, Substrates are 6-tuliposide A > 6-tuliposide B


This is E3 ubiquitin-protein ligase CCNB1IP1 homolog protein, from Rice, contains 303 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Ubiquitin E3 ligase required for class I crossover (CO) formation during meiosis


This is Olivetolic acid cyclase protein, from Hemp, contains 101 amino acids, is soluble, locates in Cytoplasm.

Involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity (PubMed:22802619), Polyketide cyclase which functions in concert with OLS/TKS to form olivetolic acid (PubMed:22802619, PubMed:26783002), Has no intrinsic polyketide synthase activity and requires the presence of OLS to produce olivetolic acid (PubMed:22802619)


This is L-amino acid oxidase Lm29 protein, from South American bushmaster, contains 516 amino acids, is soluble, locates in Extracellular.

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:22963728), Is highly active on L-Met=L-Leu>>L-Phe>L-Trp>L-Tyr>L-Ile, and weakly or not active on L-His, L-Arg, L-Val, L-Gln, L-Thr, L-Lys, and L-Ser (PubMed:22963728), Exhibits a low myotoxicity (a mild myonecrosis is observed after injection in mice quadriceps muscle) (PubMed:22963728), In vitro, is cytotoxic to a lot of human cell lines, including AGS (IC(50)=22,7 ug/ml), MCF-7 (IC(50)=1,4 ug/ml), HL-60, HeLa and Jurkat cells, as well as to the parasite Leishmania brasiliensis (IC(50)=2,22 ug/ml) (PubMed:22963728), This cytotoxicity is dependent on the production of hydrogen peroxyde, since it is inhibited by catalase, a hydrogen peroxyde scavenger (PubMed:22963728)

Belongs to the flavin monoamine oxidase family, FIG1 subfamily


This is Riboflavin biosynthesis protein PYRR, chloroplastic protein, from Maize, contains 623 amino acids, locates in Plastid.

Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products, Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do, Has no activity against GTP, nucleoside monophosphates or ADP-ribose

In the C-terminal section; belongs to the YbiA family


This is UBX domain-containing protein 8 protein, from Human, contains 270 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane, May play a role in reproduction


This is Toll-like receptor 4 protein, from Human, contains 839 amino acids, is membrane-bound, locates in Cell membrane.

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195), Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195, PubMed:21393102), Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+), Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192), Both M,tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303), In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36, This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187), Stimulation of monocytes in vitro with M,tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205, PubMed:10835634, PubMed:15809303, PubMed:17478729, PubMed:20037584, PubMed:20711192, PubMed:23880187, PubMed:27022195, PubMed:9237759), Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (PubMed:29038465)

Belongs to the Toll-like receptor family


This is E3 ubiquitin-protein ligase RNF103 protein, from Human, contains 685 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway


This is Menin protein, from Human, contains 615 amino acids, locates in Nucleus.

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4), Functions as a transcriptional regulator, Binds to the TERT promoter and represses telomerase expression, Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity, Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA, Positively regulates HOXC8 and HOXC6 gene expression, May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity), May be involved in DNA repair


This is E3 SUMO-protein ligase CBX4 protein, from Human, contains 560 amino acids, locates in Nucleus.

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530), PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530), Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity), Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity)


This is Guided entry of tail-anchored proteins factor 1 protein, from Human, contains 174 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539), Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed:21444755, PubMed:23041287, PubMed:24392163, PubMed:27226539), Required to ensure correct topology and ER insertion of CAMLG (PubMed:31417168, PubMed:32187542)


This is 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor protein, from Human, contains 319 amino acids, is membrane-bound, locates in Cell membrane.

Proton-sensing G protein-coupled receptor

Belongs to the G-protein coupled receptor 1 family


This is NEDD4-like E3 ubiquitin-protein ligase WWP2 protein, from Human, contains 870 amino acids, locates in Nucleus.

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level, Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death, Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2, Ubiquitinates RPB1 and promotes it to proteasomal degradation


This is C-C chemokine receptor-like 2 protein, from Human, contains 344 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for CCL19 and chemerin/RARRES2, Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors, Plays a critical role for the development of Th2 responses


This is Histone deacetylase complex subunit SAP18 protein, from Human, contains 153 amino acids, locates in Cytoplasm.

Component of the SIN3-repressing complex, Enhances the ability of SIN3-HDAC1-mediated transcriptional repression, When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins, Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs, The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism, Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets, The ASAP complex can inhibit mRNA processing during in vitro splicing reactions, The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis, Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function


This is Exocyst complex component 5 protein, from Human, contains 708 amino acids, is soluble, locates in Cytoplasm.

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane


This is Butyrophilin subfamily 3 member A3 protein, from Human, contains 584 amino acids, has 2 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like V-type

Plays a role in T-cell responses in the adaptive immune response

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Butyrophilin subfamily 3 member A1 protein, from Human, contains 513 amino acids, has 2 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like V-type

Plays a role in T-cell activation and in the adaptive immune response, Regulates the proliferation of activated T-cells, Regulates the release of cytokines and IFNG by activated T-cells, Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate


This is Cytochrome c oxidase subunit NDUFA4 protein, from Human, contains 81 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation, The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase, Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water, Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)), The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (PubMed:22902835), NDUFA4 is required for complex IV maintenance (PubMed:22902835)

Belongs to the complex IV NDUFA4 subunit family


This is Zinc finger protein 593 protein, from Human, contains 134 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:32669547), Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity (PubMed:9115366)

Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family


This is Receptor-binding cancer antigen expressed on SiSo cells protein, from Human, contains 213 amino acids, is membrane-bound, locates in Golgi apparatus.

May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases


This is U3 small nucleolar ribonucleoprotein protein MPP10 protein, from Human, contains 681 amino acids, locates in Nucleus.

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP), Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)


This is Serine/threonine-protein phosphatase 6 catalytic subunit protein, from Human, contains 305 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700), PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379), N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194), During mitosis, regulates spindle positioning (PubMed:27335426), Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228), Participates also in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956), Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32753499, PubMed:32474700), CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700)

Belongs to the PPP phosphatase family, PP-6 (PP-V) subfamily


This is Nucleoside diphosphate kinase, mitochondrial protein, from Human, contains 187 amino acids, is membrane-bound, locates in Mitochondrion.

Major role in the synthesis of nucleoside triphosphates other than ATP, The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate, Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505), Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663), Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542), Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086), In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids, Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663)


This is Stearoyl-CoA desaturase protein, from Human, contains 359 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284), Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284), Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069), Plays an important role in lipid biosynthesis, Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity), Plays an important role in body energy homeostasis (By similarity), Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)

Belongs to the fatty acid desaturase type 1 family


This is Protein held out wings protein, from Fruit fly, contains 405 amino acids, locates in Nucleus.

Required for integrin-mediated cell-adhesion in wing blade, Vital role in steroid regulation of muscle development and to control heart rate, Required during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization


This is Serine/threonine-protein kinase nekl-2 protein, from Caenorhabditis elegans, contains 357 amino acids, is soluble, locates in Cytoplasm.

Probable serine/threonine-protein kinase required for the completion of molting, May play a role in endocytosis in the hypodermis syncytium


This is Mechanosensory abnormality protein 6 protein, from Caenorhabditis elegans, contains 377 amino acids, is membrane-bound, locates in Cell membrane.

Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity) (PubMed:12478294), Interacts with degenerin channel proteins and stabilizes the channel (PubMed:12478294), Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:12478294, PubMed:12385749)


This is Vacuolar protein sorting-associated protein 51 homolog protein, from Caenorhabditis elegans, contains 700 amino acids, locates in Golgi apparatus.

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) (PubMed:21613545), The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi (PubMed:21613545), Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1 (PubMed:27191843), Important for neuronal function (PubMed:27191843)


This is Emerin homolog 1 protein, from Caenorhabditis elegans, contains 166 amino acids, is membrane-bound, locates in Nucleus.

Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis (PubMed:11870211, PubMed:12684533, PubMed:22171324), Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina (PubMed:11870211, PubMed:12684533), Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells (PubMed:22171324), Together with lem-2, plays a role in baf-1 enrichment at the nuclear envelope in anaphase (PubMed:12684533), Together with lem-2, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization (PubMed:22171324), May play a role in radiation-induced DNA damage repair response (PubMed:22383942), May repress binding of transcription factor pha-4 with target sequences in pharyngeal cells


This is Males-absent on the first protein protein, from Fruit fly, contains 827 amino acids, has 1 C2HC MYST-type Zinc finger, locates in Nucleus.

C2HC MYST-type

Histone acetyltransferase that plays a direct role in the specific histone acetylation associated with dosage compensation as part of the male-specific lethal (MSL) complex (PubMed:9155031, PubMed:16543150, PubMed:34133927), Dosage compensation ensures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes (PubMed:9155031), May be directly involved in the acetylation of histone 4 at 'Lys-16' on the X chromosome of males where it is recruited by the MSL complex (PubMed:11258702), As part of the nonspecific lethal (NLS) complex may associate with promoters of X chromosomal as well as autosomal genes and positively regulate their transcription through chromatin modification (PubMed:20620954)


This is Aryl hydrocarbon receptor nuclear translocator homolog protein, from Caenorhabditis elegans, contains 453 amino acids, locates in Nucleus.

Transcription factor (PubMed:17628356), Efficient DNA binding requires dimerization with another bHLH protein, such as cky-1 or ahr-1 (PubMed:17628356, PubMed:9501178), Regulates transcription of target genes, probably acting in complex with cky-1 (PubMed:17628356), Has a role in cellular differentiation (PubMed:9501178, PubMed:15136141), Required for pharyngeal development (PubMed:14757639), In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration (PubMed:14757639), Acts in the cellular response to hypoxia (PubMed:11427734), Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons (PubMed:16919260)


This is AT-rich interactive domain-containing protein cfi-1 protein, from Caenorhabditis elegans, contains 467 amino acids, locates in Nucleus.

Transcription factor (PubMed:11959845, PubMed:28056346), Regulates neuronal subtype identity (PubMed:11959845, PubMed:28056346), Involved in motor neuron fate determination and maintenance, acting as a transcriptional repressor to counteract gene activation by transcription factor unc-3 in a subset of motor neurons (PubMed:28056346), Probably acts by binding to specific promoter elements (PubMed:28056346), Promotes differentiation of URA sensory neurons and prevents them from expressing male-specific CEM neuronal features (PubMed:11959845), Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression (PubMed:11959845)


This is General odorant-binding protein lush protein, from Fruit fly, contains 153 amino acids, is soluble, locates in Extracellular.

Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons, Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons, Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex, Required for cVA response, probably by binding to VA, May act by serving as an adapter that bridges the presence of gaseous pheromone molecules, cVA, to activation of specific neuronal receptors expressed on T1 olfactory neurons, possibly via a specific conformational change induced by cVA that in turn activates T1 receptors, T1 neurons are excited by the pheromone VA, while T2 neurons are inhibited by alcohols, Also binds to phthalates


This is Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA protein, from Pig, contains 659 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the maturation of Asn-linked oligosaccharides, Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Belongs to the glycosyl hydrolase 47 family


This is Protein CUP-SHAPED COTYLEDON 2 protein, from Mouse-ear cress, contains 375 amino acids, locates in Nucleus.

Transcription activator of STM and KNAT6, Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation, Required for the fusion of septa of gynoecia along the length of the ovaries, Activates the shoot formation in callus in a STM-dependent manner, Controls leaf margin development and required for leaf serration, Involved in axillary meristem initiation and separation of the meristem from the main stem, Regulates the phyllotaxy throughout the plant development, Seems to act as an inhibitor of cell division


This is Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 2 protein, from Mouse-ear cress, contains 376 amino acids, locates in Endoplasmic reticulum.

Heterodimeric geranyl(geranyl)-diphosphate (GPP) synthase large subunit, In vitro, the large subunit catalyzes mainly the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate while the small subunit alone is inactive, Upon association of the two subunits, the product profile is not changed


This is D-3-phosphoglycerate dehydrogenase 2, chloroplastic protein, from Mouse-ear cress, contains 624 amino acids, locates in Plastid.

Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB)

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family


This is Calreticulin-3 protein, from Mouse-ear cress, contains 424 amino acids, is soluble, locates in Endoplasmic reticulum.

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle, This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER, Required for elongation factor Tu receptor (EFR) accumulation and for EFR, but not flagellin-sensing 2 (FLS2) signaling


This is Peroxisomal nicotinamide adenine dinucleotide carrier protein, from Mouse-ear cress, contains 331 amino acids, is membrane-bound, locates in Peroxisome.

Mediates the NAD(+) import into peroxisomes, Favors the NAD(+)(in)/AMP(out) antiport exchange, but is also able to catalyze a low unidirectional transport that might be essential under special conditions, Transports CoA, dephospho-CoA, acetyl-CoA, adenosine 3',5'-diphosphate (PAP), NAD(+), AMP, ADP and NADH, but has no activity with ATP, GTP, GDP, NADPH, NADP(+) or FAD, Required for peroxisomes proliferation

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Protein EARLY FLOWERING 4 protein, from Mouse-ear cress, contains 111 amino acids, locates in Nucleus.

Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles, Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9, Increases ELF3 nuclear distribution and localization in nuclear bodies, Required for responsiveness to continuous red, by regulating phytochrome B (phyB) signaling (including during seedling de-etiolation) and gene expression, Mediates both entrainment to an environmental cycle and circadian rhythm sustainability under constant conditions, Controls flowering time, Necessary for light-induced expression of both CCA1 and LHY


This is Importin subunit alpha-3 protein, from Mouse-ear cress, contains 531 amino acids, locates in Nucleus.

Binds to conventional NLS motifs and mediates nuclear protein import across the nuclear envelope (By similarity), Acts as cellular receptor for the nuclear import of the virD2 protein of Agrobacterium, but is not essential for Agrobacterium-mediated root transformation (PubMed:18836040), May be involved in the regulation of pathogen-induced salicylic acid accumulation (PubMed:15964279)


This is PYK10-binding protein 1 protein, from Mouse-ear cress, contains 298 amino acids, is soluble, locates in Cytoplasm.

Inhibitor-type lectin that may regulate the correct polymerization of BGLU23/PYK10 upon tissue damage, Activates BGLU21, BGLU22 and BGLU23


This is Tubulin-folding cofactor A protein, from Mouse-ear cress, contains 113 amino acids, is soluble, locates in Cytoplasm.

Tubulin-folding protein involved in the control of the alpha-/beta-tubulin monomer balance, Functions as a reservoir of bound and non-toxic beta-tubulin, Required in the developing embryo


This is Double-stranded RNA-binding protein 1 protein, from Mouse-ear cress, contains 419 amino acids, locates in Nucleus.

Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS), Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus, Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1, Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA), Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs, Involved with argonaute 1 (AGO1) in the guide strand selection from miRNA duplexes, presumably by directional loading of the miRNA duplex (guide stand and passenger strand) onto the RNA-induced silencing complex (RISC) for passenger strand degradation, Does not participate in sense transgene-induced post-transcriptional gene silencing (S-PTGS), Involved in several plant development aspects and response to hormones through its role in miRNAs processing


This is Metalloendoproteinase 2-MMP protein, from Mouse-ear cress, contains 378 amino acids, is membrane-bound, locates in Cell membrane.

Matrix metalloproteinases (MMPs) or matrixins may play a role in the degradation and remodeling of the extracellular matrix (ECM) during development or in response to stresses (By similarity), Required for plant growth, morphogenesis, and development with particular relevance for flowering and senescence (PubMed:11726650), Active on McaPLGLDpaAR-NH(2) (QF24) and myelin basic protein (MBP) and, to some extent, on beta-casein (PubMed:24156403)

Belongs to the peptidase M10A family, Matrix metalloproteinases (MMPs) subfamily


This is G-protein coupled receptor 1 protein, from Mouse-ear cress, contains 326 amino acids, is membrane-bound, locates in Cell membrane.

Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate(IP(3)) as a second messenger, Promotes PI-PLC activity and IP(3) accumulation, Involved in the blue light (BL) signaling, Together with GPA1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings, Probably involved in cytokinin signal transduction, Plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination, probably independently of a heterotrimeric G-protein, Mediates seed dormancy abolition, and promotes seed germination and flowering

Belongs to the G-protein coupled receptor 2 family


This is Folate synthesis bifunctional protein, mitochondrial protein, from Garden pea, contains 515 amino acids, locates in Mitochondrion.

Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis

In the C-terminal section; belongs to the DHPS family


This is Ferrochelatase-2, chloroplastic protein, from Mouse-ear cress, contains 512 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the last step of heme biosynthesis by inserting ferrous iron into protoporphyrin IX to produce protoheme, Produces heme for photosynthetic cytochromes, and for proteins involved in abiotic and biotic stress responses (PubMed:24329537), May play a role in the quality control of individual chloroplasts during photo-oxidative stress through regulation of heme biosynthesis (PubMed:26494759)


This is Biotin carboxylase, chloroplastic protein, from Mouse-ear cress, contains 537 amino acids, locates in Plastid.

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA


This is Mesoderm posterior protein 2 protein, from Mouse, contains 370 amino acids, locates in Nucleus.

Transcription factor with important role in somitogenesis, Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways, Regulates also the FGF signaling pathway, Specifies the rostral half of the somites, Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand, Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling, Acts as a strong suppressor of Notch activity, Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm, May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes, Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1, Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers


This is Retinoic acid early-inducible protein 1-alpha protein, from Mouse, contains 253 amino acids, is membrane-bound, locates in Cell membrane.


This is Retinoic acid early-inducible protein 1-beta protein, from Mouse, contains 253 amino acids, is membrane-bound, locates in Cell membrane.


This is Retinoic acid early-inducible protein 1-gamma protein, from Mouse, contains 253 amino acids, is membrane-bound, locates in Cell membrane.


This is Ornithine decarboxylase antizyme 2 protein, from Mouse, contains 189 amino acids, locates in Nucleus.

Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels, Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers, Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:24967154), Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338)


This is Recombining binding protein suppressor of hairless-like protein protein, from Mouse, contains 515 amino acids, locates in Nucleus.

Putative transcription factor, which cooperates with EBNA2 to activate transcription


This is Sulfhydryl oxidase 1 protein, from Guinea pig, contains 613 amino acids, is soluble, locates in Extracellular.

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide, Plays a role in disulfide bond formation in a variety of extracellular proteins, In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family


This is Krueppel-like factor 10 protein, from Rat, contains 480 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3', Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver, Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis, May play a role in the cell cycle regulation (By similarity), Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is 5-hydroxytryptamine receptor 1B protein, from Guinea pig, contains 389 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling inhibits adenylate cyclase activity, Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways, Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior, Besides, plays a role in vasoconstriction of cerebral arteries (By similarity)


This is Numb-like protein protein, from Mouse, contains 604 amino acids, is soluble, locates in Cytoplasm.

Plays a role in the process of neurogenesis, Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate, Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis, Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity, Negative regulator of NF-kappa-B signaling pathway, The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons


This is Histone deacetylase 1 protein, from Mouse, contains 482 amino acids, locates in Nucleus.

Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10615135, PubMed:15542849, PubMed:21960634, PubMed:30279482), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10615135, PubMed:15542849, PubMed:21960634), Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10615135, PubMed:21960634), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity), Also functions as deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3 and TSHZ3 (By similarity), Deacetylates SP proteins, SP1 and SP3, and regulates their function (By similarity), Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons (By similarity), Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation (By similarity), Deacetylates TSHZ3 and regulates its transcriptional repressor activity (By similarity), Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B (By similarity), Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity (By similarity), Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228), Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (PubMed:15226430, PubMed:24736997), Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (PubMed:15226430), In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:30279482)

Belongs to the histone deacetylase family, HD type 1 subfamily


This is Netrin-1 protein, from Mouse, contains 604 amino acids, is soluble, locates in Extracellular.

Netrins control guidance of CNS commissural axons and peripheral motor axons, Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively, Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977), Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977), It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis, Involved in colorectal tumorigenesis by regulating apoptosis (By similarity)


This is WD repeat-containing protein srw1 protein, from Fission yeast, contains 556 amino acids, locates in Nucleus.

Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2, Down-regulates the level of cdc13, particularly in a nitrogen deprived environment, Regulator of cell cycle G1 phase progression, Prevents onset of mitosis during the pre-Start G1 period, Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit

Belongs to the WD repeat CDC20/Fizzy family


This is DNA replication fork-blocking protein FOB1 protein, from Baker's yeast, contains 566 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Required for replication fork blocking activity at the replication fork barrier (RFB) site in rDNA and for recombination hot-spot (HOT1) activity, regulating the recombination rate and the number of rDNA copies, Binds directly to two separated sequences in the RFB


This is Ubiquitin-like protein pmt3/smt3 protein, from Fission yeast, contains 117 amino acids, locates in Nucleus.

Required for chromosome segregation where it may be involved in microtubule assembly, Loss of smt3 leads to an increase in telomere length

Belongs to the ubiquitin family, SUMO subfamily


This is ATP-dependent RNA helicase ded1 protein, from Fission yeast, contains 636 amino acids, is soluble, locates in Cytoplasm.

ATP-binding RNA helicase involved in translation initiation, Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity), Inactivation of ded1 blocks mitotic cell cycle progression at G1 and G2/M, Induces sexual development and ascus formation

Belongs to the DEAD box helicase family, DDX3/DED1 subfamily


This is Serine hydroxymethyltransferase, cytosolic protein, from Yeast, contains 470 amino acids, is soluble, locates in Cytoplasm.


This is Ribosomal protein arginine N-methyltransferase rmt3 protein, from Fission yeast, contains 543 amino acids, has 1 C2H2-type Zinc finger, is soluble, locates in Cytoplasm.

Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in ribosomal protein rps2

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family


This is Non-structural maintenance of chromosome element 6 protein, from Fission yeast, contains 522 amino acids, locates in Nucleus.

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks, May prevent formation of excessive Holliday junctions or assist in their resolution


This is RNA-binding post-transcriptional regulator csx1 protein, from Fission yeast, contains 632 amino acids, is soluble, locates in Cytoplasm.

Regulates global gene expression after oxidative stress, Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover


This is General transcription and DNA repair factor IIH helicase subunit XPB protein, from Fission yeast, contains 804 amino acids, locates in Nucleus.

ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, The ATPase activity of XPB/ptr8, but not its helicase activity, is required for DNA opening, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, The ATP-dependent helicase activity of XPB/ptr8 is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription (By similarity), Plays a role in mRNA export (PubMed:17212653)

Belongs to the helicase family, RAD25/XPB subfamily


This is Cullin-1 protein, from Fission yeast, contains 767 amino acids, is soluble, locates in Cytoplasm.

Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins, The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component, SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2


This is RNA-binding protein involved in heterochromatin assembly dri1 protein, from Fission yeast, contains 604 amino acids, has 3 RanBP2-type Zinc finger, locates in Nucleus.

Mediates heterochromatin assembly by promoting RNAi-mediated heterochromatin silencing and histone deacetylation (PubMed:33693625), Binds pericetromeric transcripts and recruits the RNA-induced transcriptional silencing (RITS) complex to heterochromatin (PubMed:33693625), Recruits sir2 to chromatin to promote deacetylation of 'Lys-9' of histone H3 (PubMed:33693625)


This is E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1 protein, from Fission yeast, contains 254 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains, Involved in maintaining genome stability where it acts in the cellular response to DNA damage, Has a role in meiosis


This is mRNA decapping complex subunit 2 protein, from Fission yeast, contains 741 amino acids, is soluble, locates in Cytoplasm.

Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay, Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP, Decapping is the major pathway of mRNA degradation in yeast, It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body

Belongs to the Nudix hydrolase family, DCP2 subfamily


This is Terminal uridylyltransferase cid1 protein, from Fission yeast, contains 405 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic uridylyltransferase that mediates the terminal uridylation of mRNAs with short poly(A) tails such as such as act1, hcn1 and urg1 mRNAs, hence facilitating global mRNA decay (PubMed:17353264, PubMed:17449726, PubMed:19430462, PubMed:22751018, PubMed:22885303), Uridylates the 3' ends of actin mRNAs upon S-phase arrest (PubMed:17353264), Has also a weak poly(A) polymerase (PAP) activity (PubMed:22751018, PubMed:22885303), Residue His-336 is responsible for the specificity for UTP (PubMed:22751018, PubMed:22885303), Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis (PubMed:10757807)

Belongs to the DNA polymerase type-B-like family


This is 4-aminobutyrate aminotransferase protein, from Fission yeast, contains 474 amino acids, is soluble, locates in Cytoplasm.

Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source, Deaminates GABA to succinate-semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase, Cannot transaminate beta-alanine (BAL)

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family


This is G2-specific protein kinase fin1 protein, from Fission yeast, contains 722 amino acids, is soluble, locates in Cytoplasm.

Promotes chromosome condensation and nuclear envelope dynamics during mitosis, Activity appears at metaphase-anaphase transition

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, NIMA subfamily


This is Bifunctional polynucleotide phosphatase/kinase protein, from Fission yeast, contains 408 amino acids, locates in Nucleus.

Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini, Has a role in the repair of breaks in single-stranded DNA

In the N-terminal section; belongs to the DNA 3' phosphatase family


This is Hypoxanthine-guanine phosphoribosyltransferase protein, from Fission yeast, contains 206 amino acids, locates in Endoplasmic reticulum.

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate, Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine, Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity)

Belongs to the purine/pyrimidine phosphoribosyltransferase family


This is GTP-binding protein rho3 protein, from Fission yeast, contains 205 amino acids, is membrane-bound, locates in Cell membrane.

Involved in controlling cell shape and septation (PubMed:12415007), Regulates cell separation by modulating the function of the exocyst complex (PubMed:12930742), Involved in post-Golgi vesicle transport (PubMed:12930742), Involved in driving sexual development in a palmitoylation-dependent manner (PubMed:23843742)

Belongs to the small GTPase superfamily, Rho family


This is Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4b protein, from Fission yeast, contains 685 amino acids, locates in Nucleus.

tRNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in tRNAs at position 49 and 50 (PubMed:30646830), Trm4a and trm4b methylate different sets of tRNAs (PubMed:30646830), Also methylates cytosine to m5C at positions (60, 61 and 62) in tRNA(Asp) (PubMed:23074192)

Belongs to the class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family, TRM4 subfamily


This is Chromatin modification-related protein eaf3 protein, from Fission yeast, contains 337 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair (By similarity), Also involved in deacetylation of histones, chromatin assembly and chromosome segregation, May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains


This is Serine/threonine-protein kinase hal4 protein, from Fission yeast, contains 636 amino acids, is soluble, locates in Cytoplasm.

Promotes K(+) uptake, by the potassium transporter trk1-trk2, which leads to the subsequent cellular resistance to toxic cations such as Na(+), Li(+) and Ca(2+)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is RbAp48-related WD40 repeat-containing protein prw1 protein, from Fission yeast, contains 431 amino acids, locates in Nucleus.

Has a role in chromatin assembly and chromosome segregation, Involved in the deacetylation of histones


This is DIS3-like exonuclease 2 protein, from Fission yeast, contains 927 amino acids, is soluble, locates in Cytoplasm.

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation, Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'

Belongs to the RNR ribonuclease family, DIS3L2 subfamily


This is Importin subunit alpha-1 protein, from Fission yeast, contains 542 amino acids, locates in Nucleus.

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif, Promotes docking of import substrates to the nuclear envelope, Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs, Has an essential role in mitotic chromosome condensation, Involved in nuclear protein import, Required for efficient nuclear import of both an SV40 nuclear localization signal-containing reporter protein and the pap1 component of the stress response MAP kinase pathway, Required for proper mitotic progression


This is DNA damage response protein Mdb1 protein, from Fission yeast, contains 624 amino acids, locates in Nucleus.

Involved in DNA damage response (DDR) mediated through its interaction with phosphorylated H2A proteins hta1 and hta2 which mark the discrete foci of DNA damage


This is 5-aminolevulinate synthase, mitochondrial protein, from Fission yeast, contains 558 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family


This is CTD kinase subunit alpha protein, from Fission yeast, contains 593 amino acids, locates in Nucleus.

Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity), Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD, Required for nuclear localization of ctk2/lsc1, Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in response to perturbation of the actomyosin ring, Acts in parallel to clp1 to promote actomyosin ring stability upon cytokinesis checkpoint activation

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily


This is Protein phosphatase 2C homolog 4 protein, from Fission yeast, contains 383 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Has a role in the regulation of vacuole fusion


This is ER-phagy receptor 1 protein, from Fission yeast, contains 380 amino acids, has 1 C2H2-type Zinc finger, locates in Endoplasmic reticulum.

Reticulophagy receptor required for autophagosomal sequestration of endoplasmic reticulum (ER) membranes during ER stress (Ref,5), Confers resistance to ER stress by promoting the autophagic degradation of the ER (ER-phagy or reticulophagy) (Ref,5), Acts as a bridging molecule to mediate the association between atg8 on the autophagic membrane and the vesicle-associated membrane protein-associated proteins (VAPs) scs2 and scs22 on the ER (Ref,5), May play a role in meiosis (PubMed:16303567)


This is Serine/threonine-protein kinase sid1 protein, from Fission yeast, contains 471 amino acids, is soluble, locates in Cytoplasm.

Has a role in the septation initiation network (SIN) required for cytokinesis

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily


This is Nucleoporin npp106 protein, from Fission yeast, contains 933 amino acids, locates in Nucleus.

Has a role in promoting mRNA export from the nucleus

Belongs to the nucleoporin interacting component (NIC) family


This is Swi1-interacting protein swi3 protein, from Fission yeast, contains 181 amino acids, locates in Nucleus.

Forms a fork protection complex (FPC) with swi1, FPC coordinates leading and lagging strand synthesis and moves with the replication fork, It is required for programmed fork-pausing which is necessary for mating-type switching, FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors, It is involved in termination at the mat1-proximal polar-terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1


This is Copper chaperone for superoxide dismutase protein, from Human, contains 274 amino acids, is soluble, locates in Cytoplasm.

Delivers copper to copper zinc superoxide dismutase (SOD1)

In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family


This is Potassium channel subfamily K member 3 protein, from Human, contains 394 amino acids, is membrane-bound, locates in Cell membrane.

pH-dependent, voltage-insensitive, background potassium channel protein, Rectification direction results from potassium ion concentration on either side of the membrane, Acts as an outward rectifier when external potassium concentration is low, When external potassium concentration is high, current is inward

Belongs to the two pore domain potassium channel (TC 1,A,1,8) family


This is Trace amine-associated receptor 5 protein, from Human, contains 337 amino acids, is membrane-bound, locates in Cell membrane.

Olfactory receptor specific for trimethylamine, a trace amine, Also activated at lower level by dimethylethylamine, Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food, This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase

Belongs to the G-protein coupled receptor 1 family


This is Free fatty acid receptor 1 protein, from Human, contains 300 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis, Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1), May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity), Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration, Seems to act through a G(q) and G(i)-mediated pathway, Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation


This is [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial protein, from Human, contains 412 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways, Key enzyme that regulate the activity state of the BCKD complex

Belongs to the PDK/BCKDK protein kinase family


This is Krueppel-like factor 11 protein, from Human, contains 512 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor (PubMed:9748269, PubMed:10207080), Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492), Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity), Induces apoptosis (By similarity)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Natural cytotoxicity triggering receptor 3 protein, from Human, contains 201 amino acids, has 1 Ig-like Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1, Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands, It controls, for instance, NK cells cytotoxicity against tumor cells, Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation

Belongs to the natural cytotoxicity receptor (NCR) family


This is Transcription factor EC protein, from Human, contains 347 amino acids, locates in Nucleus.

Transcriptional regulator that acts as a repressor or an activator, Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence), Binds to element F in an E-box sequence-specific manner, Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity), Collaborates with MITF in target gene activation (By similarity), Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity), Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity), Binds DNA in a homo- or heterodimeric form


This is Aurora kinase A protein, from Human, contains 403 amino acids, is soluble, locates in Cytoplasm.

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485), Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000), Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426), Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871), Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013), Regulates KIF2A tubulin depolymerase activity (PubMed:19351716), Important for microtubule formation and/or stabilization (PubMed:18056443), Required for normal axon formation (PubMed:19812038), Plays a role in microtubule remodeling during neurite extension (PubMed:19668197), Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041), Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964), Inhibits cilia outgrowth (By similarity), Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351), Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily


This is Heterogeneous nuclear ribonucleoprotein D-like protein, from Human, contains 420 amino acids, locates in Cytoplasm.

Acts as a transcriptional regulator, Promotes transcription repression, Promotes transcription activation in differentiated myotubes (By similarity), Binds to double- and single-stranded DNA sequences, Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity), Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs, Binds both to nuclear and cytoplasmic poly(A) mRNAs, Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers, Binds to the 5'-ACUAGC-3' RNA consensus sequence


This is Apoptosis-resistant E3 ubiquitin protein ligase 1 protein, from Human, contains 823 amino acids, is soluble, locates in Cytoplasm.

E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (PubMed:25752577), E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:23479728, PubMed:31578312), Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (PubMed:23479728), Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312)


This is Inhibitor of nuclear factor kappa-B kinase subunit alpha protein, from Human, contains 745 amino acids, locates in Cytoplasm.

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576), Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576, PubMed:35952808), These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576), In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:9244310, PubMed:9252186, PubMed:9346484, PubMed:18626576), Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11) (PubMed:21765415), Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation, As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes (PubMed:20501937), In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis, Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK, Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities (PubMed:17434128), Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342), Additionally, phosphorylates the CREBBP-interacting protein NCOA3, Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor (PubMed:15084260), Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity), Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (PubMed:30217973)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily


This is 1-acyl-sn-glycerol-3-phosphate acyltransferase beta protein, from Human, contains 278 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is Muscle, skeletal receptor tyrosine-protein kinase protein, from Human, contains 869 amino acids, has 3 Ig-like Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like

Ig-like

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362), Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May positively regulate Rho family GTPases through FNTA, Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is DNA-directed RNA polymerases I and III subunit RPAC1 protein, from Human, contains 346 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively, RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)

Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family


This is T-box transcription factor T protein, from Human, contains 435 amino acids, locates in Nucleus.

Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation, Binds to a palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence and activates gene transcription when bound to such a site


This is WD repeat-containing protein 46 protein, from Human, contains 610 amino acids, locates in Nucleus.

Scaffold component of the nucleolar structure, Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)


This is Kynurenine 3-monooxygenase protein, from Human, contains 486 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702), Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development, Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable)

Belongs to the aromatic-ring hydroxylase family, KMO subfamily


This is Telethonin protein, from Human, contains 167 amino acids, is soluble, locates in Cytoplasm.

Muscle assembly regulating factor, Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk


This is DNA-directed RNA polymerase I subunit RPA34 protein, from Human, contains 510 amino acids, locates in Nucleus.

Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex

Belongs to the eukaryotic RPA34 RNA polymerase subunit family


This is Nucleoporin NUP42 protein, from Human, contains 423 amino acids, has 1 C3H1-type Zinc finger, is membrane-bound, locates in Nucleus.

(Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope


This is DNA-directed RNA polymerase II subunit RPB4 protein, from Human, contains 142 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element, The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft, The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity)

Belongs to the eukaryotic RPB4 RNA polymerase subunit family


This is ATP-dependent RNA helicase DDX3Y protein, from Human, contains 660 amino acids, locates in Cytoplasm.

Probable ATP-dependent RNA helicase, During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity)

Belongs to the DEAD box helicase family, DDX3/DED1 subfamily


This is Retinoschisin protein, from Human, contains 224 amino acids, is soluble, locates in Extracellular.

Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity), May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (PubMed:27114531), Required for normal structure and function of the retina (PubMed:19093009)


This is Free fatty acid receptor 2 protein, from Human, contains 330 amino acids, is membrane-bound, locates in Cell membrane.

G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity, In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers, SCFAs serve as a source of energy but also act as signaling molecules, That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301), Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation, May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine, May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake, Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes, In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines, May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils, In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097), Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604), Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016)


This is Intermediate conductance calcium-activated potassium channel protein 4 protein, from Human, contains 427 amino acids, is membrane-bound, locates in Cell membrane.

Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990), Activation is followed by membrane hyperpolarization which promotes calcium influx, Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614), Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580)

Belongs to the potassium channel KCNN family, KCa3,1/KCNN4 subfamily


This is ATP-dependent 6-phosphofructokinase protein, from Trypanosoma brucei brucei, contains 487 amino acids, locates in Peroxisome.

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Belongs to the phosphofructokinase type A (PFKA) family, PPi-dependent PFK group II subfamily, Atypical ATP-dependent clade 'X' sub-subfamily


This is Glutathione-independent glyoxalase DJR-1.2 protein, from Caenorhabditis elegans, contains 186 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step, May play a role in detoxifying endogenously produced glyoxals, Involved in protection against glyoxal-induced cell death, Protects dopaminergic neurons from glyoxal-dependent neuronal degeneration

Belongs to the peptidase C56 family, DJ-1 subfamily


This is Fidgetin-like protein 1 protein, from Caenorhabditis elegans, contains 594 amino acids, locates in Nucleus.

Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis, Required for fertility


This is Paralyzed arrest at two-fold protein 6 protein, from Caenorhabditis elegans, contains 375 amino acids, is soluble, locates in Cytoplasm.

Involved in the regulation of cell adhesion and cytoskeleton organization, Component of an integrin containing attachment complex, which is required for muscle development and maintenance (PubMed:22253611), During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112 (PubMed:12781130, PubMed:23283987), Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells (PubMed:12781130, PubMed:23283987), During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles (PubMed:16495308)


This is Forkhead box protein O protein, from Caenorhabditis elegans, contains 541 amino acids, locates in Cytoplasm.

Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345), Transcript level in the early adult may play a role in lifespan modulation, but effect is more significant than that played by isoform a (PubMed:24834345)


This is Cell death abnormality protein 8 protein, from Caenorhabditis elegans, contains 458 amino acids, is membrane-bound, locates in Cell membrane.

Phospholipid scramblase that acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:24225442, PubMed:23845944), Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment (PubMed:24225442, PubMed:23845944), Regulates apoptosis kinetics during embryonic development (PubMed:10882128, PubMed:1936965, PubMed:24225442, PubMed:23845944), Not required for engulfment of germ cell corpses (PubMed:9927601)


This is DNA topoisomerase 1 protein, from Caenorhabditis elegans, contains 806 amino acids, locates in Nucleus.

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand, The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity), Required for normal spermatogenesis and oogenesis (PubMed:16943775)

Belongs to the type IB topoisomerase family


This is Major royal jelly protein 1 protein, from Honeybee, contains 432 amino acids, is soluble, locates in Extracellular.

Lacks antibacterial and antifungal activity, Lacks cytolytic activity and does not induce rat peritoneal mast cell degranulation

Belongs to the major royal jelly protein family


This is Paired box protein Pax-6 protein, from Fruit fly, contains 857 amino acids, locates in Nucleus.


This is Importin subunit beta protein, from Fruit fly, contains 884 amino acids, is soluble, locates in Cytoplasm.

Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins (PubMed:11102382), In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup (PubMed:23885126)

Belongs to the importin beta family, Importin beta-1 subfamily


This is Transmembrane GTPase fzo protein, from Fruit fly, contains 718 amino acids, is membrane-bound, locates in Mitochondrion.

Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis (PubMed:9230308, PubMed:18799731), In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (PubMed:9230308, PubMed:18799731), Essential for fertility (PubMed:9230308)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, Mitofusin subfamily


This is Protein phosphatase 1 regulatory subunit 14A protein, from Pig, contains 147 amino acids, is soluble, locates in Cytoplasm.

Inhibitor of PPP1CA, Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction


This is Secreted frizzled-related protein 1 protein, from Bovine, contains 308 amino acids, is soluble, locates in Extracellular.

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts, They have a role in regulating cell growth and differentiation in specific cell types, SFRP1 decreases intracellular beta-catenin levels (By similarity), Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response, In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity), In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity), Inhibits WNT1/WNT4-mediated TCF-dependent transcription

Belongs to the secreted frizzled-related protein (sFRP) family


This is Geranylgeranyl pyrophosphate synthase 6, mitochondrial protein, from Mouse-ear cress, contains 336 amino acids, locates in Mitochondrion.

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate


This is RNA polymerase sigma factor sigB protein, from Mouse-ear cress, contains 572 amino acids, locates in Plastid.

Required for the transition of plastids into chloroplasts by coordinating nuclear and chloroplastic genomes under light conditions, Sigma factors are initiation factors that promote the attachment of plastid-encoded RNA polymerase (PEP) to specific initiation sites and are then released, Promotes the biosynthesis of plastid-encoded tRNAs (e,g, trnE-UUC and trnV-UAC)


This is Transcription factor CPC protein, from Mouse-ear cress, contains 94 amino acids, locates in Nucleus.

Transcription factor, Determines the fate of epidermal cell differentiation, Represses trichome development by lateral inhibition, Together with GL3 or BHLH2, promotes the formation of hair developing cells (H position) in root epidermis, probably by inhibiting non-hair cell formation, Represses the expression of GL2 and WER in H cells, Positively regulates stomatal formation in the hypocotyl (PubMed:19513241)


This is AT-hook motif nuclear-localized protein 22 protein, from Mouse-ear cress, contains 317 amino acids, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs), Binds an AT-rich DNA sequences in the FLOWERING LOCUS T (FT) promoter (PubMed:22442143), Acts redundantly with AHL18, AHL27 and AHL29 in the regulation of flowering and regulation of the hypocotyl elongation, Plays a role in both photo- and skotomorphogenesis (PubMed:19517252), Acts as a chromatin remodeling factor that modifies the architecture of FLOWERING LOCUS T (FT) chromatin by modulating both H3 acetylation and methylation leading to the regulation of FT expression during flowering induction (PubMed:22442143)


This is Protein BRI1-5 ENHANCED 1 protein, from Mouse-ear cress, contains 364 amino acids, is soluble, locates in Cytoplasm.

Element of the brassinosteroid metabolic pathway that regulates typhasterol (TY), castasterone (CS) and brassinolide (BL) levels (PubMed:17521414), Involved in the control of organ elongation (PubMed:17521414, PubMed:23893742)

Belongs to the NAD(P)-dependent epimerase/dehydratase family


This is Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial protein, from Mouse-ear cress, contains 480 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine, Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, Involved in mitochondrial genome maintenance (By similarity), May have a role in embryonic development in plants


This is Axial regulator YABBY 1 protein, from Mouse-ear cress, contains 229 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Involved in the abaxial cell fate determination during embryogenesis and organogenesis, Regulates the initiation of embryonic shoot apical meristem (SAM) development (PubMed:10323860, PubMed:10331982, PubMed:10457020, PubMed:11812777, PubMed:12417699, PubMed:9878633, Ref,3, Ref,6, PubMed:19837869), Required during flower formation and development, particularly for the patterning of floral organs, Positive regulator of class B (AP3 and PI) activity in whorls 2 and 3, Negative regulator of class B activity in whorl 1 and of SUP activity in whorl 3, Interacts with class A proteins (AP1, AP2 and LUG) to repress class C (AG) activity in whorls 1 and 2, Contributes to the repression of KNOX genes (STM, KNAT1/BP and KNAT2) to avoid ectopic meristems, Binds DNA without sequence specificity, In vitro, can compete and displace the AP1 protein binding to DNA containing CArG box (PubMed:10323860, PubMed:10331982, PubMed:10457020, PubMed:11812777, PubMed:12417699, PubMed:9878633, Ref,3, Ref,6)


This is Cytokinin dehydrogenase 1 protein, from Mouse-ear cress, contains 575 amino acids, locates in Lysosome/Vacuole.

Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group (PubMed:11504909, PubMed:14555694), Catalyzes in vitro the oxidation of various types of cytokinin nucleotides that are known as direct products of cytokinin biosynthesis (PubMed:20825956), Promotes adventitious root initiation downstream of MYC2-dependent jasmonate signaling (PubMed:34329421), Cytokinin degraded by CKX1 is required for cell division in the female gametophyte by modulating the expression of cell cycle genes (PubMed:35995110)

Belongs to the oxygen-dependent FAD-linked oxidoreductase family