This is M-zodatoxin-Lt6a/b protein, from Spider, contains 116 amino acids, is soluble, locates in Extracellular.

Does not have antimicrobial activity against neither Gram-positive bacteria (A,globiformis VKM Ac-1112 (MIC>70 uM), and B,subtilis VKM B-501 (MIC>70 uM)), nor Gram-negative bacteria (E,coli DH5-alpha (MIC>70 uM), E,coli MH1 (MIC>70 uM), and P,aeruginosa PAO1 (MIC>70 uM)), nor yeasts (P,pastoris GS115 (MIC>70 uM), and S,cerevisiae Y190 (MIC>70 uM)), Does not have hemolytic activity against rabbit erythrocytes, However, it causes some conductance changes in planar bilayer membranes, without membrane rupture, suggesting a cytolytic function on other biological targets, It causes paralysis, but is not lethal when injected into insect (M,domestica) larvae


This is M-zodatoxin-Lt5a protein, from Spider, contains 93 amino acids, is soluble, locates in Extracellular.

Has antimicrobial activity against, Gram-positive bacteria (A,globiformis VKM Ac-1112 (MIC=1,1 uM), and B,subtilis VKM B-501 (MIC=0,6 uM)), Gram-negative bacteria (E,coli DH5-alpha (MIC=0,6 uM), E,coli MH1 (MIC=0,6 uM), and P,aeruginosa PAO1 (MIC=18 uM)), and yeasts (P,pastoris GS115 (MIC>37 uM), and S,cerevisiae Y190 (MIC>37 uM)), Also has a moderate hemolytic activity against rabbit erythrocytes, Causes paralysis, but is not lethal when injected into insect (M,domestica) larvae

Belongs to the cationic peptide 03 (latarcin) family, 05 subfamily


This is Neuromedin-S protein, from Oriental fire-bellied toad, contains 145 amino acids, is soluble, locates in Extracellular.

Stimulates uterine smooth muscle contraction (By similarity), Synthetic peptide NmS-17 induces calcium mobilization in CHO cells transfected with either human FM-3/GPR66 (EC(50)=0,085 nM) or FM-4/TGR-1 (EC(50)=0,231 nM) NmU/NmS receptors


This is Voltage-gated hydrogen channel 1 protein, from Transparent sea squirt, contains 342 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the voltage-dependent proton permeability of excitable membranes, Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient (By similarity)


This is Prostate-associated microseminoprotein protein, from Human, contains 139 amino acids, is soluble, locates in Extracellular.

Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:24442440), Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:24442440), Exhibits a chemotactic activity for monocytes and lymphocytes but not neutrophils (PubMed:24442440)

Belongs to the beta-microseminoprotein family


This is Exoribonuclease II, mitochondrial protein, from Fission yeast, contains 957 amino acids, locates in Mitochondrion.

Required for intron-independent turnover and processing of mitochondrial RNA, Participates in 3'-mtRNA processing where it hydrolyzes single-stranded RNA or partially double-stranded RNA with 3'-single-stranded tails


This is Chromatin assembly factor 1 subunit rlf2 protein, from Fission yeast, contains 544 amino acids, locates in Nucleus.

Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro, It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer, May facilitate the efficient and timely assembly of histones into telomeric chromatin (By similarity)


This is Phosphatidylserine decarboxylase proenzyme 1, mitochondrial protein, from Toxoplasma gondii (strain ATCC 50853 / GT1), contains 427 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer), Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine

Belongs to the phosphatidylserine decarboxylase family, PSD-B subfamily, Eukaryotic type I sub-subfamily


This is Serine/arginine-rich SC35-like splicing factor SCL28 protein, from Mouse-ear cress, contains 236 amino acids, locates in Nucleus.

Involved in intron recognition and spliceosome assembly (Probable), Probably active at the 5' splice sites

Belongs to the splicing factor SR family, SCL subfamily


This is Magnesium transporter MRS2-6, mitochondrial protein, from Mouse-ear cress, contains 408 amino acids, is membrane-bound, locates in Mitochondrion.

Magnesium transporter that mediates the influx/efflux of magnesium in a concentration-dependent manner, Plays a crucial role in male gametophyte development and male fertility

Belongs to the CorA metal ion transporter (MIT) (TC 1,A,35,5) family


This is Nucleolin 2 protein, from Mouse-ear cress, contains 636 amino acids, locates in Nucleus.

Involved in pre-rRNA processing and ribosome assembly


This is Sterile alpha motif domain-containing protein 11 protein, from Mouse, contains 542 amino acids, locates in Nucleus.

May play a role in photoreceptor development


This is Fatty acyl-CoA synthetase B protein, from Social amoeba, contains 673 amino acids, locates in Endoplasmic reticulum.

Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process

Belongs to the ATP-dependent AMP-binding enzyme family


This is Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1 protein, from Caenorhabditis elegans, contains 468 amino acids, locates in Nucleus.

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily


This is Suppressor of activated egl-4 protein 1 protein, from Caenorhabditis elegans, contains 900 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

As a likely component of a histone deacetylase complex, together with saeg-2 and hda-2, functions downstream of the cAMP-dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging


This is Translational repressor ifet-1 protein, from Caenorhabditis elegans, contains 761 amino acids, is soluble, locates in Cytoplasm.

Involved in translational repression of multiple mRNAs in the distal gonad (PubMed:23264733), Recruited to the 3' untranslated region (UTR) of zif-1 by oma-1 and is required for translational repression of zif-1 (PubMed:20826530), May also be involved in translational repression of mei-1 through recruitment to the mei-1 3' UTR by oma-1 (PubMed:19786575), Required for oogenesis but not spermatogenesis, for P granule formation and for the localization of car-1 and cgh-1 to P granules (PubMed:23264733), Required for normal spindle orientation in early embryos (PubMed:19786575)


This is Intermediate filament protein ifa-3 protein, from Caenorhabditis elegans, contains 581 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic intermediate filaments provide mechanical strength to cells, Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle, Required for epidermal morphogenesis in embryos, Probable component of embryonic epidermal attachment structures

Belongs to the intermediate filament family


This is Dihydropyrimidinase 1 protein, from Caenorhabditis elegans, contains 489 amino acids, locates in Nucleus.

Belongs to the metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family


This is Acetyl-CoA acetyltransferase homolog, mitochondrial protein, from Caenorhabditis elegans, contains 407 amino acids, locates in Mitochondrion.

Plays a role in ketone body metabolism (By similarity), Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin (PubMed:24204312), Acts downstream of sir-2,1 to regulate aging and stress resistance (PubMed:20956318)

Belongs to the thiolase-like superfamily, Thiolase family


This is T-box transcription factor tbx-9 protein, from Caenorhabditis elegans, contains 292 amino acids, locates in Nucleus.

Transcription factor (By similarity), Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle (PubMed:15066124, PubMed:15102704), Involved in regulating expression of vab-7 (PubMed:15102704), Appears to have partially redundant function to tbx-8 (PubMed:15066124), Positively modulates expression of homeobox protein lin-39, perhaps by binding to regulatory regions of the lin-39 gene, acting in the vulval lineage


This is T-box transcription factor tbx-8 protein, from Caenorhabditis elegans, contains 315 amino acids, locates in Nucleus.

Transcription factor (By similarity), Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle (PubMed:15066124, PubMed:15102704), Involved in regulating expression of vab-7 (PubMed:15102704), Appears to have partially redundant function to tbx-9 (PubMed:15066124)


This is Importin subunit alpha-1 protein, from Caenorhabditis elegans, contains 524 amino acids, is soluble, locates in Cytoplasm.

Binds specifically and directly to substrates containing either a simple or bipartite NLS motif, Promotes docking of import substrates to the nuclear envelope, Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity)


This is Homeobox protein ceh-30 protein, from Caenorhabditis elegans, contains 237 amino acids, locates in Nucleus.

Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination, In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway


This is Lysosomal beta glucosidase protein, from Social amoeba, contains 821 amino acids, locates in Lysosome/Vacuole.

Belongs to the glycosyl hydrolase 3 family


This is Fatty-acid and retinol-binding protein 1 protein, from Onchocerca volvulus, contains 178 amino acids, is soluble, locates in Extracellular.

Binds retinol, Also binds the fluorescent fatty acids 11-((5-dimethylaminonaphthalene-1-sulfonyl)amino)undecanoic acid (DAUDA), dansyl-DL-alpha-aminocaprylic acid (DACA) and parinaric acid, Binds long chain fatty acids, with highest affinity for arachidonic acid, linoleic acid and oleic acid, These long chain fatty acids can act competitively to displace bound fluorescent fatty acids and retinol, May compete with host albumin for fatty acid-binding

Belongs to the fatty-acid and retinol-binding protein (FARBP) family


This is AT-rich binding protein protein, from Flesh fly, contains 354 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

May be a transcription factor for genes having (A+T) stretches in their promoter and/or enhancer regions, Binds to AT rich DNA


This is Cathepsin L protein, from Flesh fly, contains 339 amino acids, locates in Lysosome/Vacuole.

Important for the overall degradation of proteins in lysosomes, Required for differentiation of imaginal disks


This is Protein lin-15A protein, from Caenorhabditis elegans, contains 719 amino acids, locates in Nucleus.

Synthetic multivulva (synMuv) class A protein (PubMed:7982579, PubMed:8054684), SynMuv proteins are required to repress the induction of vulval development (PubMed:7982579, PubMed:8054684), Acts redundantly with SynMuv class B protein lin-15B, and lin-35 to negatively regulate vulval development, most likely through antagonization of the Ras-signaling pathway (PubMed:8054684, PubMed:16624904), May also negatively regulate vulval development in association with other SynMuv class B proteins such as dpl-1 and efl-1 (PubMed:11463372), Regulates let-23 basal activity (PubMed:8054684), Required for the correct expression and/or stability of lin-56 (PubMed:21196525)


This is Tribbles homolog 2 protein, from Dog, contains 343 amino acids, is soluble, locates in Cytoplasm.

Interacts with MAPK kinases and regulates activation of MAP kinases, Does not display kinase activity

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily


This is Protein DBF4 homolog B protein, from African clawed frog, contains 784 amino acids, has 1 DBF4-type Zinc finger, locates in Nucleus.

Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation, Specifically required during the initiation of DNA replication in egg and during early embryonic development, The complex cdc7-dbf4b phosphorylates mcm2 and mcm4 subunits and is required for cdc45 loading


This is Pregnancy-associated glycoprotein 1 protein, from Sheep, contains 382 amino acids, is soluble, locates in Extracellular.


This is UDP-galactose/UDP-glucose transporter 2 protein, from Mouse-ear cress, contains 345 amino acids, is membrane-bound, locates in Golgi apparatus.

Sugar transporter involved in the transport of UDP-galactose form the cytoplasm into the Golgi apparatus

Belongs to the nucleotide-sugar transporter family, UDP-galactose:UMP antiporter (TC 2,A,7,11) subfamily


This is Iota-conotoxin LtIIIA protein, from Lettered cone, contains 69 amino acids, is soluble, locates in Extracellular.

Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels, This toxin enhances tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons


This is Endo-1,4-beta-xylanase 2 protein, from Black yeast, contains 361 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Hydrolyzes birch-wood xylan, with a similar activity toward oat-spelt xylan, Also shows weak activities toward pNP-beta-D-cellobioside and pNP-beta-D-xylopyranoside, but no detectable activity toward carboxymethyl cellulose and pNP-beta-L-arabinofuranoside,-

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Endo-1,4-beta-xylanase A protein, from Penicillium citrinum, contains 217 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is Protein SCARECROW 2 protein, from Rice, contains 660 amino acids, is soluble, locates in Cytoplasm.

Probable transcription factor involved in asmmetric cell division in the cortex/endodermis progenitor cell and in the process of stomata and ligule formation in leaves


This is Auxin response factor 23 protein, from Rice, contains 853 amino acids, locates in Nucleus.

Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs)


This is Bidirectional sugar transporter SWEET14 protein, from Rice, contains 303 amino acids, is membrane-bound, locates in Cell membrane.

Confers blight susceptibility (PubMed:25988582), Confers TAL effector-mediated susceptibility to Xanthomonas oryzae pv, oryzae (PubMed:23879865)

Belongs to the SWEET sugar transporter family


This is Golgi SNAP receptor complex member 1 protein, from Bovine, contains 250 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport, It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor, May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14), Participates in docking and fusion stage of ER to cis-Golgi transport, Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity)


This is Dipeptidyl peptidase 4 protein, from Yellow koji mold, contains 771 amino acids, is soluble, locates in Extracellular.

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline


This is Myomodulin neuropeptides 2 protein, from California sea hare, contains 240 amino acids, is soluble, locates in Extracellular.

MMG2-DPs (Myomodulin gene 2-derived peptides) bias egestive feeding programs toward ingestive ones, and modulate accessory radula closer (ARC) muscle contractions


This is Magnesium transporter MRS2-7 protein, from Mouse-ear cress, contains 386 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Low-affinity magnesium transporter that mediates the influx of magnesium


This is Small ribosomal subunit protein mS27 protein, from Bovine, contains 415 amino acids, locates in Mitochondrion.

RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis, Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain, Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu), Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues

Belongs to the mitochondrion-specific ribosomal protein mS27 family


This is Acyl-coenzyme A thioesterase 6 protein, from Mouse, contains 419 amino acids, locates in Peroxisome.

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels, Catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet

Belongs to the C/M/P thioester hydrolase family


This is Snake venom vascular endothelial growth factor toxin protein, from Taiwan habu, contains 143 amino acids, is soluble, locates in Extracellular.

Snake venom VEGFs may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension, This protein activates the vascular endothelial growth factor receptor-1 (VEGFR-1/FLT1), and consequently promotes the proliferation and tissue factor production of endothelial cells, the neovascularization in the chicken chorioallantoic membrane, and increases vascular permeability, Also stimulates tissue-factor production and human monocyte chemotaxis

Belongs to the PDGF/VEGF growth factor family, Snake venom VEGF subfamily


This is Chalcone 4'-O-glucosyltransferase protein, from Garden snapdragon, contains 457 amino acids, is soluble, locates in Cytoplasm.

Glycosyltransferase involved in the biosynthesis of aurones, plant flavonoids that provide yellow coloration to flowers

Belongs to the UDP-glycosyltransferase family


This is Kinetoplastid membrane protein 11 protein, from Leishmania donovani, contains 92 amino acids, is soluble, locates in Cytoplasm.

May be involved in the regulation of the cytoskeleton through interaction with the subpellicular microtubules, May be involved in parasite mobility and attachment to the surface of the host cell, Strongly stimulates T-cell proliferation and is thought to play a role in the immunology of leishmaniasis


This is ATP-dependent DNA helicase PIF4 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 819 amino acids, is soluble, locates in Mitochondrion.

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability

Belongs to the helicase family, PIF1 subfamily


This is ATP-dependent protease ATPase subunit HslU2 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 496 amino acids, is soluble, locates in Mitochondrion.

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity, The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV, HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity), The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels

Belongs to the ClpX chaperone family, HslU subfamily


This is ATP-dependent DNA helicase PIF3 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 812 amino acids, is soluble, locates in Cytoplasm.

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability


This is Pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial protein, from Mouse-ear cress, contains 363 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)


This is Chaperone protein dnaJ 1, mitochondrial protein, from Mouse-ear cress, contains 408 amino acids, has 1 CR-type Zinc finger, locates in Mitochondrion.

CR-type

Plays a continuous role in plant development probably in the structural organization of compartments

Belongs to the DnaJ family, B/II subfamily


This is Rhodanese-like domain-containing protein 15, chloroplastic protein, from Mouse-ear cress, contains 182 amino acids, locates in Plastid.


This is Preprotein translocase subunit SCY1, chloroplastic protein, from Mouse-ear cress, contains 551 amino acids, is membrane-bound, locates in Plastid.

Involved in protein export, Probably interacts with other proteins to allow the translocation of proteins across the chloroplast thylakoid membranes, Required for normal greening during embryogenesis, Central subunit of the protein translocation channel SecYE, Consists of two halves formed by TMs 1-5 and 6-10, These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back, The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug (By similarity)


This is Glutamate dehydrogenase 2 protein, from Mouse-ear cress, contains 411 amino acids, locates in Mitochondrion.

Belongs to the Glu/Leu/Phe/Val dehydrogenases family


This is Cyclic pyranopterin monophosphate synthase, mitochondrial protein, from Mouse-ear cress, contains 270 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)


This is Protein DEHYDRATION-INDUCED 19 protein, from Mouse-ear cress, contains 206 amino acids, locates in Nucleus.


This is 2S seed storage albumin protein protein, from Pumpkin, contains 141 amino acids, locates in Lysosome/Vacuole.

Belongs to the 2S seed storage albumins family


This is Dynamin-related protein 12A protein, from Soybean, contains 610 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated force-producing protein that is targeted to the forming cell plate during cytokinesis, May be involved in attaching Golgi-derived vesicles to microtubules which direct vesicles to the forming cell plate during cytokinesis, Possesses intrinsic GTPase activity in vitro

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Disintegrin EO4A protein, from Ocellated saw-scaled viper, contains 128 amino acids, is soluble, locates in Extracellular.

Poor inhibitor of platelet aggregation, The disintegrin inhibits the adhesion of cells expressing the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin, Inhibition on alpha-2b/beta-3 (ITGA2B/ITGB3) is low

Belongs to the disintegrin family, Dimeric disintegrin subfamily


This is Disintegrin EO5A protein, from Ocellated saw-scaled viper, contains 115 amino acids, is soluble, locates in Extracellular.

Poor inhibitor of platelet aggregation, The disintegrin inhibits the adhesion of the alpha-4/beta-1 (ITGA4/ITGB1) integrin to VCAM-1, Inhibition on alpha-IIb/beta-3 (ITGA2B/ITGB3) is low


This is Serine palmitoyltransferase-regulating protein TSC3 protein, from Baker's yeast, contains 80 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stimulates the activity of serine palmitoyltransferase (SPT)


This is COX assembly mitochondrial protein 2 protein, from Baker's yeast, contains 109 amino acids, is membrane-bound, locates in Mitochondrion.

Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration, May be involved in copper trafficking and distribution to mitochondrial COX and SOD1


This is Cytochrome c oxidase assembly factor 3, mitochondrial protein, from Baker's yeast, contains 85 amino acids, is membrane-bound, locates in Mitochondrion.

Required for assembly of cytochrome c oxidase (complex IV), With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1


This is General transcription and DNA repair factor IIH subunit TFB5 protein, from Baker's yeast, contains 72 amino acids, locates in Nucleus.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II, In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment, In transcription, TFIIH has an essential role in transcription initiation, When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape, Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription, TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits


This is Protein QQS protein, from Mouse-ear cress, contains 59 amino acids, is soluble, locates in Cytoplasm.

Involved in regulating carbon and nitrogen allocation to starch and protein (PubMed:25146936)


This is Cell division cycle 20.5, cofactor of APC complex protein, from Mouse-ear cress, contains 450 amino acids, locates in Nucleus.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle

Belongs to the WD repeat CDC20/Fizzy family


This is Probable anion transporter 6, chloroplastic protein, from Mouse-ear cress, contains 517 amino acids, is membrane-bound, locates in Plastid.

Inorganic phosphate and probable anion transporter

Belongs to the major facilitator superfamily, Sodium/anion cotransporter (TC 2,A,1,14) family


This is Protein MID1-COMPLEMENTING ACTIVITY 2 protein, from Mouse-ear cress, contains 416 amino acids, is membrane-bound, locates in Cell membrane.

Calcium-permeable stretch-activated channel component, Probably involved in mechanosensing and in mechano-stimulated calcium uptake mechanism


This is 2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic protein, from Mouse-ear cress, contains 261 amino acids, locates in Plastid.

Involved in the biosynthesis of phylloquinone (vitamin K1), Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol

Belongs to the class I-like SAM-binding methyltransferase superfamily, MenG/UbiE family


This is Acyl-coenzyme A thioesterase 6 protein, from Human, contains 421 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels, Catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet


This is Large ribosomal subunit protein uL10m protein, from Bovine, contains 262 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL10 family


This is Small ribosomal subunit protein uS7m protein, from Bovine, contains 242 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS7 family


This is Inter-alpha-trypsin inhibitor heavy chain H4 protein, from Bovine, contains 916 amino acids, is soluble, locates in Extracellular.

Type II acute-phase protein (APP) involved in inflammatory responses to trauma, May also play a role in liver development or regeneration


This is Serum albumin protein, from Giant fire-bellied toad, contains 607 amino acids, is soluble, locates in Extracellular.

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs, Its main function is the regulation of the colloidal osmotic pressure of blood (By similarity), Potent inhibitor of trypsin but has no inhibitory effect on thrombin, chymotrypsin, elastase and subtilisin


This is IGF-like family receptor 1 protein, from Mouse, contains 345 amino acids, is membrane-bound, locates in Cell membrane.

Probable cell membrane receptor for the IGF-like family protein IGFL


This is Transforming growth factor beta regulator 1 protein, from Mouse, contains 406 amino acids, locates in Nucleus.

Acts as a growth inhibitor, Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis, Redistributes CDKN2A into the nucleoplasm, Involved in maintaining chromosomal stability


This is Cilia- and flagella-associated protein 418 protein, from Mouse, contains 209 amino acids, is soluble, locates in Cytoplasm.

May be involved in photoreceptor outer segment disk morphogenesis


This is Prostate and testis expressed protein 14 protein, from Mouse, contains 99 amino acids, is soluble, locates in Extracellular.


This is Multicilin protein, from Mouse, contains 379 amino acids, locates in Nucleus.

Transcription regulator specifically required for multiciliate cell differentiation, Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis, Required for the deuterosome-mediated acentriolar pathway, Plays a role in mitotic cell cycle progression by promoting cell cycle exit, Modulates GMNN activity by reducing its affinity for CDT1


This is Tear acid lipase-like protein protein, from Golden hamster, contains 398 amino acids, is soluble, locates in Extracellular.

Female-specific protein which lacks detectable lipase activity against a range of substrates, Binds the hydrophobic lipid 1-aminoanthracene with high affinity

Belongs to the AB hydrolase superfamily, Lipase family


This is CDGSH iron-sulfur domain-containing protein 1 protein, from Bovine, contains 106 amino acids, is membrane-bound, locates in Mitochondrion.

L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (By similarity), The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine), The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate, The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (By similarity), Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity), May be involved in iron-sulfur cluster shuttling and/or in redox reactions, Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (By similarity)


This is Zinc finger protein 260 protein, from Human, contains 412 amino acids, has 13 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling, Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA, Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein FAM220A protein, from Mouse, contains 260 amino acids, locates in Nucleus.


This is Histone H3.2 protein, from Trumpet lily, contains 136 amino acids, locates in Nucleus.

Core component of nucleosome, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity)


This is Histone H3.3a protein, from Trumpet lily, contains 136 amino acids, locates in Nucleus.

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes, Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis, Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling


This is Tobamovirus multiplication protein 1 protein, from Common tobacco, contains 288 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Necessary for the efficient intracellular multiplication of tobamoviruses, probably being a membrane anchor promoting the formation of the replication complex

Belongs to the plant tobamovirus multiplication TOM1 protein family


This is Ethylene-responsive transcription factor 4 protein, from Common tobacco, contains 225 amino acids, locates in Nucleus.

Acts as a transcriptional repressor, Binds to the GCC-box pathogenesis-related promoter element, Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways mediated by ethylene, that seems to depend on a protein kinase/phosphatase cascade, and to be influenced by methyl-jasmonate, May regulate other AtERFs (By similarity)

Belongs to the ethylene-response factor family, Class 2 subfamily


This is Photosystem II reaction center W protein, chloroplastic protein, from Spinach, contains 137 amino acids, is membrane-bound, locates in Plastid.

Stabilizes dimeric photosystem II (PSII), In its absence no dimeric PSII accumulates and there is a reduction of monomeric PSII (By similarity)


This is Histone H4.3 protein, from Maize, contains 103 amino acids, locates in Nucleus.

Core component of nucleosome, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling


This is Oxygen-evolving enhancer protein 3-2, chloroplastic protein, from Mouse-ear cress, contains 230 amino acids, is membrane-bound, locates in Plastid.

Required for photosystem II assembly/stability and photoautotrophic growth under low light conditions


This is Probable aquaporin TIP2-2 protein, from Mouse-ear cress, contains 250 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes

Belongs to the MIP/aquaporin (TC 1,A,8) family, TIP (TC 1,A,8,10) subfamily


This is N-(5'-phosphoribosyl)anthranilate isomerase 1, chloroplastic protein, from Mouse-ear cress, contains 275 amino acids, locates in Plastid.

Catalyzes the conversion of 5-phosphoribosylanthranilate to l-(O-carboxyphenylamino)-l-deoxyribulose-5-phosphate, which is the third step of the tryptophan biosynthetic pathway


This is Biotin carboxyl carrier protein of acetyl-CoA carboxylase 1, chloroplastic protein, from Mouse-ear cress, contains 280 amino acids, locates in Plastid.

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA


This is Serine acetyltransferase 5 protein, from Mouse-ear cress, contains 312 amino acids, is soluble, locates in Cytoplasm.

Belongs to the transferase hexapeptide repeat family


This is NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial protein, from Mouse-ear cress, contains 218 amino acids, locates in Mitochondrion.

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis, Complex I functions in the transfer of electrons from NADH to the respiratory chain, The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)

Belongs to the complex I 20 kDa subunit family


This is Non-specific lipid-transfer protein 1 protein, from Mouse-ear cress, contains 118 amino acids, is soluble, locates in Extracellular.

Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes, May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues


This is Soluble inorganic pyrophosphatase PPA1 protein, from Potato, contains 211 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the irreversible hydrolysis of pyrophosphate (PPi) to phosphate


This is Serine/threonine-protein kinase SRPK protein, from Slime mold, contains 426 amino acids, locates in Nucleus.

Phosphorylates serine/arginine-rich protein PSR

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family


This is Protein POOR HOMOLOGOUS SYNAPSIS 1 protein, from Mouse-ear cress, contains 349 amino acids, is soluble, locates in Cytoplasm.

Required for accurate chromosome segregation in meiosis, Required for pairing to occur between homologous chromosomes, Acts in early recombination steps and ensures pairing fidelity and proper repair of meiotic DNA double-strand-breaks, Regulates recombination and pairing of homologous chromosomes during meiotic prophase by controlling transport of RAD50 from cytoplasm to the nucleus, May affect pairing of the gene-rich fraction of the genome rather than preventing pairing between repetitive DNA elements


This is Short neurotoxin 1 protein, from Australian taipan, contains 83 amino acids, is soluble, locates in Extracellular.

Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission

Belongs to the snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily


This is Cerebral dopamine neurotrophic factor protein, from Human, contains 187 amino acids, is soluble, locates in Extracellular.

Trophic factor for dopamine neurons, Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons, When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity)


This is Cytochrome c oxidase assembly protein COX19 protein, from Human, contains 90 amino acids, is soluble, locates in Cytoplasm.

Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis (PubMed:23345593), May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity)


This is ATP-dependent 6-phosphofructokinase protein, from Trypanosoma cruzi (strain CL Brener), contains 485 amino acids, locates in Peroxisome.

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Belongs to the phosphofructokinase type A (PFKA) family, PPi-dependent PFK group II subfamily, Atypical ATP-dependent clade 'X' sub-subfamily


This is Solute carrier family 52, riboflavin transporter, member 3 protein, from Rat, contains 463 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism

Belongs to the riboflavin transporter family


This is Derlin-1.1 protein, from Maize, contains 243 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins


This is Shugoshin 1 protein, from African clawed frog, contains 663 amino acids, locates in Nucleus.

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms, May act by preventing phosphorylation of the stag2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by espl1/separase at anaphase, May regulate kinetochore microtubule stability in mitosis, possibly to sense tension on mitotic chromosomes


This is Beta-insect toxin AaBTxL1 protein, from Sahara scorpion, contains 82 amino acids, is soluble, locates in Extracellular.

Shifts the voltage of activation of para/tipE voltage-dependent sodium channels (Nav) toward more negative potentials

Belongs to the long (3 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Beta-toxin KAaH2 protein, from Sahara scorpion, contains 80 amino acids, is soluble, locates in Extracellular.

Weakly inhibits the vertebrate potassium channel Kv1,1/KCNA1

Belongs to the long (3 C-C) scorpion toxin superfamily, Sodium/Potassium channel inhibitor family


This is Beta-toxin KAaH1 protein, from Sahara scorpion, contains 80 amino acids, is soluble, locates in Extracellular.

Inhibits the vertebrate potassium channels Kv1,1/KCNA1 and Kv1,3/KCNA3 in vitro with an IC(50) of 5,3 nM and 50,0 nM respectively


This is Endo-1,4-beta-xylanase 11A protein, from Corn smut fungus, contains 221 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is Nuclear distribution protein PAC1 protein, from Corn smut fungus, contains 453 amino acids, is soluble, locates in Cytoplasm.

Positively regulates the activity of the minus-end directed microtubule motor protein dynein, May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end, Required for nuclear migration during vegetative growth as well as development, Required for localization of dynein to the mitotic spindle poles, Recruits additional proteins to the dynein complex at SPBs (By similarity), Required for retrograde early endosome (EE) transport from the hyphal tip

Belongs to the WD repeat LIS1/nudF family


This is Agamous-like MADS-box protein AGL61 protein, from Mouse-ear cress, contains 264 amino acids, locates in Nucleus.

Probable transcription factor, Controls central cell differentiation during female gametophyte development


This is Hydroxyacid-oxoacid transhydrogenase, mitochondrial protein, from Rat, contains 467 amino acids, locates in Mitochondrion.

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG), L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity)

Belongs to the iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily


This is Protein leg1b protein, from Zebrafish, contains 364 amino acids, is soluble, locates in Extracellular.

Involved in early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation, In liver, its function is partially redundant with leg1a function


This is Neuromedin-S protein, from Giant fire-bellied toad, contains 145 amino acids, is soluble, locates in Extracellular.

Stimulates uterine smooth muscle contraction (EC(50)=1,6 nM), Synthetic peptide NmS-17 induces calcium mobilization in CHO cells transfected with either human FM-3/GPR66 (EC(50)=0,085 nM) or FM-4/TGR-1 (EC(50)=0,231 nM) NmU/NmS receptors


This is RNA polymerase II-associated factor 1 homolog protein, from Zebrafish, contains 503 amino acids, locates in Nucleus.

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II, PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity), PAF1C seems to be required for multiple steps in cardiac formation, Involved in the migration of myocardial precursors to the midline and the differentiation of the atrioventricular boundary in the developing heart


This is Endochitinase 2 protein, from Entomophthora anisopliae, contains 419 amino acids, is soluble, locates in Extracellular.

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods), Participates in the infection process and directly acts in the penetration process of the host cuticle

Belongs to the glycosyl hydrolase 18 family, Chitinase class III subfamily


This is Homeobox protein unplugged protein, from Fruit fly, contains 485 amino acids, locates in Nucleus.

Plays a regulatory role in neural branching of the tracheae: segment-specific aspects of these neural branching patterns appear to be generated by homeotic regulation of expression, May have a role with oc/otd in the postembryonic development of the brain


This is Katanin p80 WD40 repeat-containing subunit B1 protein, from African clawed frog, contains 655 amino acids, is soluble, locates in Cytoplasm.

Participates in a complex which severs microtubules in an ATP-dependent manner, May act to target the enzymatic subunit of this complex to sites of action such as the centrosome, Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation


This is Cytochrome P450 2U1 protein, from Rat, contains 530 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates, Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase), Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids, May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes, May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels, Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin


This is Protein CDV3 protein, from Mouse, contains 281 amino acids, is soluble, locates in Cytoplasm.


This is Transmembrane protein 65 protein, from Mouse, contains 234 amino acids, is membrane-bound, locates in Cell membrane.

May play an important role in cardiac development and function, May regulate cardiac conduction and the function of the gap junction protein GJA1, May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (PubMed:26403541), Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity)


This is Protein LURE 1.1 protein, from Mouse-ear cress, contains 94 amino acids, is soluble, locates in Extracellular.

Pollen tube attractants guiding pollen tubes to the ovular micropyle


This is Protein LURE 1.3 protein, from Mouse-ear cress, contains 91 amino acids, is soluble, locates in Extracellular.

Pollen tube attractants guiding pollen tubes to the ovular micropyle, Attracts pollen tubes from both A,thaliana and A,lyrata


This is Inosine-5'-monophosphate dehydrogenase protein, from Toxoplasma gondii, contains 551 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth


This is Erythropoietin receptor protein, from African clawed frog, contains 525 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for erythropoietin, Mediates erythropoietin-induced erythroblast proliferation and differentiation

Belongs to the type I cytokine receptor family, Type 1 subfamily


This is Tripeptidyl-peptidase sed4 protein, from Neosartorya fumigata, contains 594 amino acids, is soluble, locates in Extracellular.

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence


This is Bifunctional levopimaradiene synthase, chloroplastic protein, from Loblolly pine, contains 850 amino acids, locates in Plastid.

Involved in defensive oleoresin formation in conifers in response to insect attack or other injury, Involved in diterpene (C20) olefins biosynthesis, Bifunctional enzyme that catalyzes two sequential cyclizations of geranylgeranyl diphosphate (GGPP) to levopimaradiene, Levopimaradiene is the major products of the enzyme followed by abietadiene, neoabietadiene and palustradiene, No activity with geranyl diphosphate (GPP) or farnesyl diphosphate (FPP) as substrate

Belongs to the terpene synthase family, Tpsd subfamily


This is Cysteine protease ATG4 protein, from Rice blast fungus, contains 491 amino acids, is soluble, locates in Cytoplasm.

Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8 (PubMed:19923912), Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production, The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine, ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy, The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy, In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components, ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS (By similarity)


This is Counting factor 60 protein, from Social amoeba, contains 416 amino acids, is soluble, locates in Extracellular.

Cell-counting factor that limits the maximum size of the multicellular structure, Does not possess acid phosphatase activity, Cells with decreased levels of this protein form large groups while cells overexpressing this protein form small groups

Belongs to the histidine acid phosphatase family


This is Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB protein, from Social amoeba, contains 483 amino acids, is soluble, locates in Cytoplasm.

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Belongs to the phosphatase 2A regulatory subunit B family


This is Calcium-binding protein C protein, from Social amoeba, contains 166 amino acids, is soluble, locates in Cytoplasm.

Plays a role during cell aggregation and slug migration


This is Myb-like protein C protein, from Social amoeba, contains 580 amino acids, locates in Nucleus.

Transcription activator required for the culmination, at the time of the fruiting body formation, Regulates genes involved in the cell differentiation within the fruiting body


This is Transcription factor stalky protein, from Social amoeba, contains 872 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Probable transcription factor, Seems to act on the expression of the genes culC, culD, rnpA and sigB


This is Protein doublecortin protein, from Social amoeba, contains 308 amino acids, is soluble, locates in Cytoplasm.

Has a cytoskeleton-independent function in chemotactic signaling during development


This is NAD-dependent deacetylase sir2E protein, from Social amoeba, contains 343 amino acids, locates in Nucleus.

NAD-dependent deacetylase, which plays an important role in the regulation of transcriptional repression (By similarity), May play a role in cell cycle, When overexpressed, the cell cycle is accelerated


This is Mpv17-like protein 2 protein, from Human, contains 206 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the assembly and stability of the mitochondrial ribosome (PubMed:24948607), Is a positive regulator of mitochondrial protein synthesis (PubMed:24948607)

Belongs to the peroxisomal membrane protein PXMP2/4 family


This is Hexokinase-4 protein, from Mouse-ear cress, contains 502 amino acids, is membrane-bound, locates in Mitochondrion.

Fructose and glucose phosphorylating enzyme (By similarity), May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity)


This is Methionine aminopeptidase 2B protein, from Mouse-ear cress, contains 439 amino acids, is soluble, locates in Cytoplasm.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Belongs to the peptidase M24A family, Methionine aminopeptidase eukaryotic type 2 subfamily


This is ATP-dependent protease ATPase subunit HslU1 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 475 amino acids, is soluble, locates in Mitochondrion.

ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity, The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV, HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity), The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels

Belongs to the ClpX chaperone family, HslU subfamily


This is ATP-dependent DNA helicase PIF7 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 992 amino acids, is soluble, locates in Mitochondrion.

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability

Belongs to the helicase family, PIF1 subfamily


This is NAD-dependent protein deacylase SIR2rp2 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 306 amino acids, is soluble, locates in Mitochondrion.

NAD-dependent protein deacylase, Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues

Belongs to the sirtuin family, Class II subfamily


This is Phosphatidylserine decarboxylase proenzyme, mitochondrial protein, from Bovine, contains 416 amino acids, locates in Mitochondrion.

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer), Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine, May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (By similarity)

Belongs to the phosphatidylserine decarboxylase family, PSD-B subfamily, Eukaryotic type I sub-subfamily


This is Small ribosomal subunit protein uS9m protein, from Bovine, contains 396 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS9 family


This is Maximins 11/H1 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.

Maximin-H1 shows antibacterial activity against both Gram-positive and Gram-negative bacteria, It shows also antimicrobial activity against the fungus C,albicans, Shows strong hemolytic activity


This is Maximins 4/H3 type 4 protein, from Giant fire-bellied toad, contains 139 amino acids, is soluble, locates in Extracellular.

Maximin-H3 shows antibacterial activity against both Gram-positive and Gram-negative bacteria, It shows also antimicrobial activity against the fungus C,albicans, Shows strong hemolytic activity


This is Maximins 4/H3 type 5 protein, from Giant fire-bellied toad, contains 139 amino acids, is soluble, locates in Extracellular.


This is Maximins 4/H3 type 3 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.


This is Maximins 5/H4 type 2 protein, from Giant fire-bellied toad, contains 145 amino acids, is soluble, locates in Extracellular.

Maximin-H4 shows antibacterial activity against both Gram-positive and Gram-negative bacteria, It shows also antimicrobial activity against the fungus C,albicans, Shows strong hemolytic activity


This is Maximins 5/H4 type 3 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.


This is Maximins 4/H3 type 6 protein, from Giant fire-bellied toad, contains 139 amino acids, is soluble, locates in Extracellular.


This is Maximins 7/H1 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.


This is Maximins 4/H3 type 7 protein, from Giant fire-bellied toad, contains 139 amino acids, is soluble, locates in Extracellular.


This is Maximins 4/H3 type 2 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.


This is MFS antiporter QDR3 protein, from Yeast, contains 697 amino acids, is membrane-bound, locates in Cell membrane.

MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence, No substrate for transport has been identified yet, but plays an important role in the growth in the host

Belongs to the major facilitator superfamily, CAR1 family


This is Repressed by EFG1 protein 1 protein, from Yeast, contains 271 amino acids, is soluble, locates in Extracellular.

Cell wall protein involved in cell wall integrity and which plays a role in virulence


This is Elongation factor 2 protein, from Yeast, contains 842 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation, During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively, Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily


This is Cell wall protein IFF11 protein, from Yeast, contains 511 amino acids, is soluble, locates in Extracellular.

GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence


This is CAP1-binding-protein protein, from Yeast, contains 643 amino acids, is soluble, locates in Cytoplasm.

Involved in oxidative stress response and redox homeostasis, Required for hydrogen peroxide-induced oxidation and nuclear localization (activation) of CAP1, Functions probably in concert with GPX3, the actual CAP1 modifying enzyme


This is Secreted beta-glucosidase SIM1 protein, from Yeast, contains 372 amino acids, is soluble, locates in Extracellular.

Cell surface beta-glucosidase involved in cell wall maintenance and cytokinesis, Plays a role redundant to SUN41


This is Non-classical export protein 102 protein, from Yeast, contains 170 amino acids, is membrane-bound, locates in Cell membrane.

Involved in membrane organization, Involved in a novel pathway of export of proteins that lack a cleavable signal sequence, Non-classical export pathway functions also as an alternative clearance/detoxification pathway to eliminate damaged material, when the basic repair pathway is not sufficient (By similarity), Regulates actin organization and subsequent morphogenesis and pathogenesis


This is Cell wall protein phiA protein, from Aspergillus nidulans, contains 182 amino acids, is soluble, locates in Extracellular.

Cell wall protein involved in development of asexual structures such as phialide and conidium development, and thus required for spore formation (PubMed:14599891), Plays a role as a general stress protectant produced by the fungus in competition with antagonistic bacteria (By similarity)


This is Inactive pancreatic lipase-related protein 1 protein, from Mouse, contains 473 amino acids, is soluble, locates in Extracellular.

May function as inhibitor of dietary triglyceride digestion, Lacks detectable lipase activity (in vitro) (By similarity)

Belongs to the AB hydrolase superfamily, Lipase family


This is Inactive hyaluronidase B protein, from Yellow jacket, contains 340 amino acids, is soluble, locates in Extracellular.

Belongs to the glycosyl hydrolase 56 family


This is Ectonucleoside triphosphate diphosphohydrolase 8 protein, from Rat, contains 494 amino acids, is membrane-bound, locates in Cell membrane.

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity, Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides, Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity)


This is BTB/POZ domain-containing protein KCTD16 protein, from Mouse, contains 427 amino acids, is membrane-bound, locates in Cell membrane.

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response, Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization


This is Protein RBL protein, from Mouse-ear cress, contains 547 amino acids, locates in Nucleus.

Promotes the expression of FLC and FLC homologs to repress the floral transition (PubMed:21423667), Promotes WRKY70 and LTP7 genes epigenetic methylation (e,g, H3K4me3) and subsequent expression (PubMed:23284292)


This is Protein MCM10 homolog protein, from African clawed frog, contains 860 amino acids, locates in Nucleus.

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication, Additionally, plays a role in preventing DNA damage during replication (By similarity)


This is Cathelicidin-B1 protein, from Chicken, contains 251 amino acids, is soluble, locates in Extracellular.

Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro), May play a role in the innate immune response


This is Aspartate aminotransferase protein, from Maritime pine, contains 492 amino acids, locates in Plastid.

Prokaryotic-type aspartate aminotransferase, Specific for aspartate and no activity with glutamine, asparagine, alanine, histidine, leucine, methionine, lysine, arginine, tryptophan, tyrosine, phenylalanine or kynurenine

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is Zinc finger MYND domain-containing protein 10 protein, from African clawed frog, contains 439 amino acids, has 1 MYND-type Zinc finger, is soluble, locates in Cytoplasm.

MYND-type

Plays a role in axonemal structure organization and motility, Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity), May act by indirectly regulating transcription of dynein proteins (By similarity)


This is Ion channel POLLUX protein, from Lotus corniculatus var. japonicus, contains 917 amino acids, is membrane-bound, locates in Nucleus.

Ion channel with permeability for potassium, Involved in perinuclear calcium spiking but not in cytosolic calcium influx, Required for early signal transduction events leading to endosymbiosis, Acts early in a signal transduction chain leading from the perception of Nod factor to the activation of calcium spiking, Also involved in fungal entry into root epidermal cells during the establishment of the arbuscular mycorrhizal symbiosis

Belongs to the castor/pollux (TC 1,A,1,23) family


This is DEAD-box ATP-dependent RNA helicase 15 protein, from Rice, contains 432 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in pre-mRNA splicing, Required for the export of mRNA out of the nucleus (By similarity), Required for tapetal programmed cell death (PCD) and degeneration during anther development, Forms dimer with AIP1 and binds the promoter region of the cysteine protease CP1, Can complement the yeast RNA helicase SUB2, Plants silencing AIP1 and AIP2 are male sterile (PubMed:21467577)

Belongs to the DEAD box helicase family, DECD subfamily


This is Cytochrome P450 714D1 protein, from Rice, contains 577 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the 16alpha,17-epoxidation on non-13-hydroxylated gibberellins (GAs), including GA4, GA9, and GA12, No activity with GA1, GA20, GA53 or ent-kaurenoic acid, Reduces the biological activity of GAs


This is Speedy protein C protein, from Human, contains 293 amino acids, is soluble, locates in Cytoplasm.

Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2, Involved in the spindle-assembly checkpoint, Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores, Required for the correct localization of the active form of Aurora B in prometaphase


This is Phaiodotoxin protein, from Mafia scorpion, contains 90 amino acids, is soluble, locates in Extracellular.

Sodium channel (Nav) specific neurotoxin, Causes impairment of movement and mild paralysis in crickets at a dose of 0,5 ug per animal, A dose of 0,8 ug per cricket causes clear flaccid paralysis, A dose of 1,0 ug per cricket causes death within 2 hours

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family


This is Origin of replication complex subunit 1 protein, from Rice, contains 814 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Essential protein (By similarity), Component of the origin recognition complex (ORC) that binds origins of replication, It has a role in both chromosomal replication and mating type transcriptional silencing, Binds to the ARS consensus sequence (ACS) of origins of replication (By similarity), H3K4me3 effector that regulates positively the transcription of a subset of genes (By similarity), Required for cell proliferation (PubMed:10996242)


This is Glycoprotein endo-alpha-1,2-mannosidase protein, from Human, contains 462 amino acids, is membrane-bound, locates in Golgi apparatus.

Belongs to the glycosyl hydrolase 99 family


This is Neuferricin protein, from Mouse, contains 263 amino acids, is soluble, locates in Extracellular.

Heme-binding protein which promotes neuronal but not astrocyte differentiation

Belongs to the cytochrome b5 family, MAPR subfamily


This is DNL-type zinc finger protein protein, from Human, contains 178 amino acids, has 1 DNL-type Zinc finger, locates in Mitochondrion.

DNL-type

May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation


This is Synaptonemal complex protein 2-like protein, from Human, contains 812 amino acids, locates in Nucleus.

Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes


This is Endoplasmic reticulum membrane-associated RNA degradation protein protein, from Human, contains 678 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May play a role in neuronal migration during embryonic development


This is Transmembrane protein 135 protein, from Rat, contains 458 amino acids, is membrane-bound, locates in Peroxisome.

Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission (By similarity), May act as a regulator of mitochondrial fission that promotes DNM1L-dependent fission through activation of DNM1L (By similarity), May be involved in peroxisome organization (PubMed:17522052)


This is R-spondin-2 protein, from African clawed frog, contains 243 amino acids, is soluble, locates in Extracellular.

Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes, Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway (By similarity), Activates neural markers and promotes muscle formation, Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (PubMed:15469841), During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity)


This is TATA box-binding protein-like 2 protein, from African clawed frog, contains 320 amino acids, locates in Nucleus.

TATA box-binding transcription factor, Members of the TBP family are differentially required to regulate transcription and development during early embryogenesis, Required for gastrulation, Regulates a large subset of genes that are ventrally expressed, Binds to a subset of promoters


This is Dehydration-responsive element-binding protein 2B protein, from Rice, contains 373 amino acids, locates in Nucleus.

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3' of the cis-acting dehydration-responsive element (DRE), Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription, Involved in drought and heat-shock stress tolerance

Belongs to the AP2/ERF transcription factor family, ERF subfamily


This is PHD finger protein ALFIN-LIKE 5 protein, from Mouse-ear cress, contains 260 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Acyl-CoA-binding domain-containing protein 5 protein, from Mouse, contains 508 amino acids, is membrane-bound, locates in Peroxisome.

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy, Binds medium- and long-chain acyl-CoA esters (By similarity)


This is 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial protein, from Rat, contains 385 amino acids, locates in Mitochondrion.

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite, Has high activity toward isobutyryl-CoA, Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism, Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity)

Belongs to the enoyl-CoA hydratase/isomerase family


This is Mu-agatoxin-Ao1b protein, from Funnel-web spider, contains 70 amino acids, is soluble, locates in Extracellular.

Insecticidal neurotoxin that modulates the insect Nav channel (DmNaV1/tipE (para/tipE)) in a unique manner, with both the activation and inactivation processes being affected, The voltage dependence of activation is shifted toward more hyperpolarized potentials (analogous to site 4 toxins) and a non-inactivating persistent sodium current is induced (site 3-like action), Interestingly, both effects take place in a voltage-dependent manner, producing a bell-shaped curve between -80 and 0 mV

Belongs to the neurotoxin 07 (Beta/delta-agtx) family, 04 (aga-5) subfamily


This is Mu-agatoxin-Ao1a protein, from Funnel-web spider, contains 70 amino acids, is soluble, locates in Extracellular.


This is U3-agatoxin-Ao1k protein, from Funnel-web spider, contains 73 amino acids, is soluble, locates in Extracellular.

Insecticidal neurotoxin that modulates the insect Nav channel (DmNaV1/tipE (para/tipE)) in a unique manner, with both the activation and inactivation processes being affected, The voltage dependence of activation is shifted toward more hyperpolarized potentials (analogous to site 4 toxins) and a non-inactivating persistent sodium current is induced (site 3-like action), Interestingly, both effects take place in a voltage-dependent manner, producing a bell-shaped curve between -80 and 0 mV, Compared to beta/delta-agatoxin-1 to -3, this toxin appears to affect the insect sodium channel only weakly

Belongs to the neurotoxin 07 (Beta/delta-agtx) family, 03 (aga-4) subfamily, Aga sub-subfamily


This is U3-agatoxin-Ao1g protein, from Funnel-web spider, contains 74 amino acids, is soluble, locates in Extracellular.


This is U3-agatoxin-Ao1c protein, from Funnel-web spider, contains 73 amino acids, is soluble, locates in Extracellular.


This is U3-agatoxin-Ao1a protein, from Funnel-web spider, contains 71 amino acids, is soluble, locates in Extracellular.

Belongs to the neurotoxin 07 (Beta/delta-agtx) family, 01 (aga-2) subfamily


This is Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial protein, from Chicken, contains 157 amino acids, is membrane-bound, locates in Mitochondrion.

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)


This is 5-hydroxytryptamine receptor 1D protein, from Guinea pig, contains 376 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling inhibits adenylate cyclase activity, Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity, May also play a role in regulating the release of other neurotransmitters, May play a role in vasoconstriction

Belongs to the G-protein coupled receptor 1 family


This is Serpin B6 protein, from Mouse, contains 378 amino acids, is soluble, locates in Cytoplasm.

Inhibitor of cathepsin G, kallikrein-8 and thrombin, May play an important role in the inner ear in the protection against leakage of lysosomal content during stress, May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood

Belongs to the serpin family, Ov-serpin subfamily


This is Copper transporter 2 protein, from Rice, contains 151 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the transport of copper, in cooperation with SWEET11 and COPT1, Contributes to the removal of copper (Cu) from xylem, and thus to the sensitivity toward bacterial pathogens such as X,oryzae pv, oryzae (Xoo)

Belongs to the copper transporter (Ctr) (TC 1,A,56) family, SLC31A subfamily


This is Phosphatidylinositol-glycan biosynthesis class X protein protein, from Rat, contains 252 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis, Probably acts by stabilizing the mannosyltransferase PIGM


This is BPI fold-containing family B member 1 protein, from Mouse, contains 474 amino acids, is soluble, locates in Extracellular.

May play a role in innate immunity in mouth, nose and lungs, Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS, May be involved in formation of the left-right axis in the node of the developing embryo

Belongs to the BPI/LBP/Plunc superfamily, Plunc family


This is Carcinoembryonic antigen-related cell adhesion molecule 10 protein, from Mouse, contains 265 amino acids, has 2 Ig-like V-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like V-type

Ig-like V-type

May interact with other CEACAM proteins on the sperm surface

Belongs to the immunoglobulin superfamily, CEA family


This is Zinc finger protein ZIC 4 protein, from Mouse, contains 341 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 3 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; atypical

C2H2-type 2; atypical

Belongs to the GLI C2H2-type zinc-finger protein family


This is Allergin-1 protein, from Rat, contains 248 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells, Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)


This is Zinc finger protein 260 protein, from Rat, contains 407 amino acids, has 12 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, locates in Nucleus.

C2H2-type 2; degenerate

Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling, Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA, Also acts as a cofactor with GATA4, a key cardiac regulator

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Vesicle-trafficking protein SEC22a protein, from Rat, contains 307 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in vesicle transport between the ER and the Golgi complex


This is Protein FAM170A protein, from Mouse, contains 333 amino acids, has 1 C2H2-type; degenerate Zinc finger, locates in Nucleus.

C2H2-type; degenerate

Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes, Binds to heat shock promoter elements (HSE)


This is DNA repair protein RAD51 homolog A protein, from Maize, contains 340 amino acids, locates in Nucleus.

Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity, Unwinds duplex DNA (By similarity), Component of the meiotic recombination pathway, Seems to play a role in mediating chromosome homology search, chromosome pairing and synapsis at early stages and probably chromosome crossing-over at later stages in meiosis, Probably is involved in the repair of meiotic double strand breaks (DBSs) and in homologous recombination

Belongs to the RecA family, RAD51 subfamily


This is Nucleoporin NUP35 protein, from Rat, contains 325 amino acids, is membrane-bound, locates in Nucleus.

Functions as a component of the nuclear pore complex (NPC), NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors, May play a role in the association of MAD1 with the NPC (By similarity)


This is Alkaline serine protease ver112 protein, from Verticillium psalliotae, contains 382 amino acids, is soluble, locates in Extracellular.

Serine protease which can degrade the nematode cuticle


This is Beta-cardiotoxin CTX27 protein, from King cobra, contains 84 amino acids, is soluble, locates in Extracellular.

Acts as a beta-blocker by binding to beta-1 and beta-2 adrenergic receptors (ADRB1 and ADRB2), It dose-dependently decreases the heart rate (bradycardia), whereas conventional cardiotoxins increases it, At 100 mg/kg, intraperitoneal injection into mice provokes labored breathing, impaired locomotion, lack of response to external stimuli, and death (after 30 min)

Belongs to the snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily


This is Protein argonaute PNH1 protein, from Rice, contains 979 amino acids, is soluble, locates in Cytoplasm.

Probably involved in the RNA silencing pathway, May bind to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them (By similarity), Plays a role in the maintenance of the indeterminate state of the stem cells in the shoot apical meristem (SAM), Regulates leaf formation through vascular development and may be involved in determining the central domain of the leaf founder region

Belongs to the argonaute family, Ago subfamily


This is Zinc finger MYND domain-containing protein 10 protein, from Rat, contains 440 amino acids, has 1 MYND-type Zinc finger, is soluble, locates in Cytoplasm.

MYND-type

Plays a role in axonemal structure organization and motility, Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity), May act by indirectly regulating transcription of dynein proteins (By similarity)


This is Cytoplasmic dynein 2 light intermediate chain 1 protein, from Rat, contains 351 amino acids, is soluble, locates in Cytoplasm.

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system, facilitating the assembly of these organelles, Involved in the regulation of ciliary length

Belongs to the dynein light intermediate chain family


This is Insulin growth factor-like family member protein, from Mouse, contains 140 amino acids, is soluble, locates in Extracellular.

Probable ligand of the IGFLR1 cell membrane receptor


This is Iron-sulfur protein IND1 protein, from Yeast, contains 312 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the effective assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), Probably facilitates the assembly of Fe-S cofactors and subunits of complex I

Belongs to the Mrp/NBP35 ATP-binding proteins family


This is AN1-type zinc finger protein 6 protein, from Rat, contains 223 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger, is soluble, locates in Cytoplasm.

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis, Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1, Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6, In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity)


This is Succinate--CoA ligase [ADP-forming] subunit alpha-2, mitochondrial protein, from Tomato, contains 337 amino acids, locates in Mitochondrion.

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA, The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit

Belongs to the succinate/malate CoA ligase alpha subunit family


This is Zinc finger protein 470 protein, from Human, contains 717 amino acids, has 17 C2H2-type Zinc finger, locates in Nucleus.

May be involved in transcriptional regulation


This is DNA endonuclease RBBP8 protein, from African clawed frog, contains 856 amino acids, locates in Nucleus.

Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway, Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA


This is Defensin-1 protein, from Mexican scorpion, contains 56 amino acids, is soluble, locates in Extracellular.

Antibacterial protein involved in the immune response to septic injury, When combined with 14,026 kDa and 14,059 kDa hemolymph antimicrobial peptides, it has a strong cooperative activity against the Gram-positive bacteria B,subtilis and S,aureus, and against the Gram-negative bacteria E,coli DH5-alpha and K,pneumoniae ATCC 138833, Does not show detectable antibacterial activity when present alone, Has no hemolytic activity in human erythrocytes

Belongs to the invertebrate defensin family


This is Kallikrein-1E2 protein, from Horse, contains 261 amino acids, is soluble, locates in Extracellular.

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

Belongs to the peptidase S1 family, Kallikrein subfamily


This is Transmembrane emp24 domain-containing protein p24delta3 protein, from Mouse-ear cress, contains 217 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vesicular protein trafficking, Mainly functions in the early secretory pathway, Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity)


This is Ras-like protein family member 11A protein, from Mouse, contains 242 amino acids, locates in Nucleus.

Regulator of rDNA transcription, Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription

Belongs to the small GTPase superfamily, Ras family


This is Histone-binding protein RBBP4-B protein, from African clawed frog, contains 425 amino acids, locates in Nucleus.

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA, Component of several complexes which regulate chromatin metabolism

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family


This is Malectin-A protein, from African clawed frog, contains 276 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan, May play a role in the early steps of protein N-glycosylation, Can bind di- or higher oligomers but not monomers of glucose, including maltose, maltotriose, maltotetraose, maltoheptaose, nigerose, kojibose, cellobiose and isomaltose, although based on their subcellular locations, these are unlikely to all be physiological ligands


This is Taxoid 7-beta-hydroxylase protein, from Japanese yew, contains 500 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the conversion of taxusin to 7-beta-hydroxytaxusin in taxol biosynthesis (PubMed:15157877), Catalyzes the conversion of 2-alpha-hydroxytaxusin to 2-alpha-7-beta-hydroxytaxusin in taxol biosynthesis (PubMed:15157877)


This is Homeobox-leucine zipper protein HOX4 protein, from Rice, contains 277 amino acids, locates in Nucleus.

Probable transcription activator that binds to the DNA sequence 5'-CAAT[AT]ATTG-3', May be involved in the regulation of gibberellin signaling

Belongs to the HD-ZIP homeobox family, Class I subfamily


This is Replication protein A 32 kDa subunit A protein, from Rice, contains 279 amino acids, locates in Nucleus.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions (By similarity)

Belongs to the replication factor A protein 2 family


This is Bidirectional sugar transporter SWEET5 protein, from Rice, contains 237 amino acids, is membrane-bound, locates in Cell membrane.

Mediates both low-affinity uptake and efflux of sugar across the plasma membrane (By similarity), Can transport galactose, Prevents growth but promotes senescence (PubMed:25988582, PubMed:24709840), Involved in regulating the crosstalk between sugar and auxin, Regulates negatively the auxin signaling pathway and translocation (PubMed:24709840)

Belongs to the SWEET sugar transporter family


This is Zinc transporter 5 protein, from Rice, contains 353 amino acids, is membrane-bound, locates in Cell membrane.

Zinc transporter that mediates zinc uptake from the rhizosphere and may be responsible for the translocation of zinc within the plant

Belongs to the ZIP transporter (TC 2,A,5) family


This is Fe(2+) transport protein 2 protein, from Rice, contains 370 amino acids, is membrane-bound, locates in Cell membrane.

Iron transporter that may play a role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer


This is Glucuronoxylan 4-O-methyltransferase 1 protein, from Mouse-ear cress, contains 282 amino acids, is membrane-bound, locates in Golgi apparatus.

Methyltransferase catalyzing 4-O-methylation of glucuronic acid side chains on xylan

Belongs to the methyltransferase superfamily


This is Thioredoxin Y1, chloroplastic protein, from Mouse-ear cress, contains 172 amino acids, is soluble, locates in Plastid.

Thiol-disulfide oxidoreductase that poorly activates chloroplastic malate dehydrogenase (NADP-MDH) and fructose-1,6-bisphosphatase, Provides reducing equivalents for peroxiredoxin Q

Belongs to the thioredoxin family, Plant Y-type subfamily


This is WD repeat-containing protein DWA2 protein, from Mouse-ear cress, contains 350 amino acids, locates in Nucleus.

Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling, May function as the substrate recognition module within this complex leading to ABI5 degradation, Functionally redundant with DWA1


This is THO complex subunit 4D protein, from Mouse-ear cress, contains 288 amino acids, is soluble, locates in Nucleus.

Export adapter involved in nuclear export of spliced and unspliced mRNA (PubMed:11432957), Plays a role in disease resistance, Mediates multiple defense responses triggered by NEP1, including stomatal closure, hypersensitive cell death (HCD) and defense-related gene expression (PubMed:24723400)


This is Beta-1,3-galactosyltransferase 7 protein, from Mouse-ear cress, contains 393 amino acids, is membrane-bound, locates in Golgi apparatus.

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal glycosyl residue

Belongs to the glycosyltransferase 31 family


This is Mitotic-spindle organizing protein 2B protein, from Human, contains 158 amino acids, is soluble, locates in Cytoplasm.


This is Large ribosomal subunit protein uL14m protein, from Human, contains 145 amino acids, locates in Mitochondrion.

Forms part of 2 intersubunit bridges in the assembled ribosome, Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable)

Belongs to the universal ribosomal protein uL14 family


This is Dermokine protein, from Mouse, contains 517 amino acids, is soluble, locates in Extracellular.

May act as a soluble regulator of keratinocyte differentiation


This is GTPase IMAP family member 6 protein, from Human, contains 292 amino acids, is soluble, locates in Cytoplasm.

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily


This is Glutaredoxin-related protein 5, mitochondrial protein, from Zebrafish, contains 155 amino acids, locates in Mitochondrion.

Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:16110529), Receives iron-sulfur clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:16110529), Required for normal hemoglobin biosynthesis (PubMed:16110529)


This is BEN domain-containing protein 6 protein, from Mouse, contains 281 amino acids, locates in Nucleus.

Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis (PubMed:23571214, PubMed:25561495)


This is Endo-1,4-beta-xylanase protein, from Penicillium notatum, contains 353 amino acids, is soluble, locates in Extracellular.

Cold active endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Solute carrier family 25 member 47 protein, from Human, contains 308 amino acids, is membrane-bound, locates in Mitochondrion.

Uncoupling protein which may catalyze the physiological 'proton leak' in liver, Overexpression induces the dissipation of mitochondrial membrane potential

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Valencene synthase protein, from Grape, contains 556 amino acids, is soluble, locates in Cytoplasm.

Involved in the biosynthesis of valencene, a major volatile emitted from flowers of grapevine, Can use farnesyl diphosphate as substrate, but not geranyl diphosphate or geranylgeranyl diphosphate, Produces mainly (+)-valencene and (-)-7-epi-alpha-selinene along with five minor products

Belongs to the terpene synthase family, Tpsa subfamily


This is Bifunctional arginine demethylase and lysyl-hydroxylase PSR protein, from Hydra, contains 385 amino acids, locates in Nucleus.

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase


This is Protein ISD11 protein, from Baker's yeast, contains 94 amino acids, locates in Mitochondrion.

Required for mitochondrial iron-sulfur proteins biosynthesis


This is Metal-nicotianamine transporter YSL2 protein, from Mouse-ear cress, contains 664 amino acids, is membrane-bound, locates in Cell membrane.

May be involved in the lateral transport of nicotianamine-chelated metals in the vasculature


This is Ion channel DMI1 protein, from Barrel medic, contains 882 amino acids, is membrane-bound, locates in Nucleus.

Required for early signal transduction events leading to endosymbiosis, Acts early in a signal transduction chain leading from the perception of Nod factor to the activation of calcium spiking, Also involved in mycorrhizal symbiosis, May be involved in the regulation of the calcium channel responsible for calcium spiking by mobilizing another cation, and thereby altering the membrane potential

Belongs to the castor/pollux (TC 1,A,1,23) family


This is Short-chain dehydrogenase TIC 32, chloroplastic protein, from Garden pea, contains 316 amino acids, is membrane-bound, locates in Plastid.

Involved in protein precursor import into chloroplasts, Part of the redox regulon consisting of TIC32, TIC 55 and TIC62, Has a NADPH-dependent dehydrogenase activity, but only after preincubation with lipids

Belongs to the short-chain dehydrogenases/reductases (SDR) family