This is Peroxisomal succinyl-coenzyme A thioesterase protein, from Human, contains 421 amino acids, locates in Peroxisome.

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157), Functions as a peroxisomal succinyl-coenzyme A thioesterase that can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157)

Belongs to the C/M/P thioester hydrolase family


This is Transmembrane protein 102 protein, from Human, contains 508 amino acids, is membrane-bound, locates in Cell membrane.

Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway


This is Protein BANP protein, from Human, contains 519 amino acids, locates in Nucleus.

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function, Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer, Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels, Promotes TP53 activation, which causes cell cycle arrest (By similarity)


This is Centrosomal protein POC5 protein, from Human, contains 575 amino acids, is soluble, locates in Cytoplasm.

Essential for the assembly of the distal half of centrioles, required for centriole elongation


This is Interleukin-17 receptor C protein, from Human, contains 791 amino acids, is membrane-bound, locates in Cell membrane.


This is Mitoguardin 1 protein, from Human, contains 632 amino acids, is membrane-bound, locates in Mitochondrion.

Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers, May act by regulating phospholipid metabolism via PLD6/MitoPLD


This is Fanconi anemia group B protein protein, from Human, contains 859 amino acids, locates in Nucleus.

DNA repair protein required for FANCD2 ubiquitination


This is Golgi membrane protein 1 protein, from Human, contains 401 amino acids, is membrane-bound, locates in Golgi apparatus.

Unknown, Cellular response protein to viral infection


This is Procollagen galactosyltransferase 1 protein, from Human, contains 622 amino acids, is soluble, locates in Endoplasmic reticulum.

Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen (PubMed:19075007, PubMed:22216269, PubMed:27402836), By acting on collagen glycosylation, facilitates the formation of collagen triple helix (PubMed:27402836), Also involved in the biosynthesis of collagen type IV (PubMed:30412317)

Belongs to the glycosyltransferase 25 family


This is Inactive C-alpha-formylglycine-generating enzyme 2 protein, from Human, contains 301 amino acids, is soluble, locates in Endoplasmic reticulum.

Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form, Inhibits the activation of sulfatases by SUMF1

Belongs to the sulfatase-modifying factor family


This is SID1 transmembrane family member 2 protein, from Human, contains 832 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365), Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980), In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA, Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity)


This is Formylglycine-generating enzyme protein, from Human, contains 374 amino acids, is soluble, locates in Endoplasmic reticulum.

Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756, PubMed:21224894), 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:25931126, PubMed:16368756), Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15907468, PubMed:15657036)


This is Protein O-glucosyltransferase 1 protein, from Human, contains 392 amino acids, is soluble, locates in Endoplasmic reticulum.

Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322), Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322), Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076), Notch glucosylation does not affect Notch ligand binding (PubMed:21490058), Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity)

Belongs to the glycosyltransferase 90 family


This is Ubiquitin-associated domain-containing protein 2 protein, from Human, contains 344 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (PubMed:23297223), In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040)


This is Solute carrier family 4 member 11 protein, from Human, contains 875 amino acids, is membrane-bound, locates in Cell membrane.

Multifunctional transporter with an impact in cell morphology and differentiation, In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (PubMed:15525507), At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (By similarity), In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance (PubMed:15525507, PubMed:28642546), Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species (PubMed:28642546), In response to hypo-osmotic challenge, also acts as water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor (PubMed:31273259, PubMed:25007886, PubMed:23813972), In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (PubMed:27581649)

Belongs to the anion exchanger (TC 2,A,31) family


This is Kinetochore protein Spc24 protein, from Human, contains 197 amino acids, locates in Nucleus.

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735), Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735), The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)


This is INO80 complex subunit E protein, from Human, contains 244 amino acids, locates in Nucleus.

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is RELT-like protein 2 protein, from Human, contains 303 amino acids, is membrane-bound, locates in Cell membrane.

Induces activation of MAPK14/p38 cascade, when overexpressed (PubMed:28688764), Induces apoptosis, when overexpressed (PubMed:19969290)


This is LEM domain-containing protein 2 protein, from Human, contains 503 amino acids, is membrane-bound, locates in Nucleus.

Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070), Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070), Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692), During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070), Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity), Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity), Required for myoblast differentiation involving regulation of ERK signaling (By similarity), Essential for cardiac homeostasis and proper heart function (By similarity)


This is Nitric oxide-associated protein 1 protein, from Human, contains 698 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in regulation of mitochondrial protein translation and respiration, Plays a role in mitochondria-mediated cell death, May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes, Binds GTP

Belongs to the TRAFAC class YlqF/YawG GTPase family, NOA1 subfamily


This is Sugar phosphate exchanger 3 protein, from Human, contains 494 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (PubMed:21949678), In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containg-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899)

Belongs to the major facilitator superfamily, Organophosphate:Pi antiporter (OPA) (TC 2,A,1,4) family


This is tRNA-splicing endonuclease subunit Sen2 protein, from Human, contains 465 amino acids, locates in Nucleus.

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA, It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron, The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini, There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body, Isoform 1 probably carries the active site for 5'-splice site cleavage, The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events, Isoform 2 is responsible for processing a yet unknown RNA substrate, The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity

Belongs to the tRNA-intron endonuclease family


This is Carbohydrate sulfotransferase 4 protein, from Human, contains 386 amino acids, is membrane-bound, locates in Golgi apparatus.

Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway, Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans, Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance (PubMed:11439191, PubMed:12107080, PubMed:10330415, PubMed:11726653), Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) (PubMed:11439191), The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration, Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing, Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (By similarity), Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis (PubMed:12107080, PubMed:11439191, PubMed:11726653)

Belongs to the sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily


This is Diacylglycerol lipase-beta protein, from Human, contains 672 amino acids, is membrane-bound, locates in Cell membrane.

Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053), Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053), Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses, Functions also as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages, Plays an important role to support the metabolic and signaling demands of macrophages (By similarity)

Belongs to the AB hydrolase superfamily, Lipase family


This is E3 ubiquitin-protein ligase RNF169 protein, from Human, contains 708 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Nucleus.

RING-type

Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage, Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization (PubMed:22492721, PubMed:30773093), Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1 (PubMed:30104380, PubMed:30773093), E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair


This is C2 calcium-dependent domain-containing protein 4A protein, from Human, contains 369 amino acids, locates in Nucleus.

May be involved in inflammatory process, May regulate cell architecture and adhesion


This is Polypeptide N-acetylgalactosaminyltransferase 11 protein, from Human, contains 608 amino acids, is membrane-bound, locates in Golgi apparatus.

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1, O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO), Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor, Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1, Not involved in glycosylation of erythropoietin (EPO)

Belongs to the glycosyltransferase 2 family, GalNAc-T subfamily


This is Protein LSM14 homolog A protein, from Human, contains 463 amino acids, is soluble, locates in Cytoplasm.

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985), Acts as a repressor of mRNA translation (PubMed:29510985), May play a role in mitotic spindle assembly (PubMed:26339800)


This is Paraneoplastic antigen Ma1 protein, from Human, contains 353 amino acids, locates in Nucleus.


This is Calcium uniporter protein, mitochondrial protein, from Human, contains 351 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627), Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363), Activity is regulated by MICU1 and MICU2, At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221), Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways, Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213), While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:25603276), participates in mitochondrial permeability transition during ischemia-reperfusion injury (By similarity), Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319, PubMed:22829870), Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (By similarity), Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (By similarity), Involved in antigen processing and presentation (By similarity)


This is Phospholipase DDHD1 protein, from Human, contains 900 amino acids, is soluble, locates in Cytoplasm.

Phospholipase A1 (PLA1) that hydrolyzes ester bonds at the sn-1 position of glycerophospholipids producing a free fatty acid and a lysophospholipid (PubMed:20359546, PubMed:22922100), Prefers phosphatidate (1,2-diacyl-sn-glycero-3-phosphate, PA) as substrate in vitro, but can efficiently hydrolyze phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol), PI), as well as a range of other glycerophospholipid substrates such as phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) and phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (PubMed:20359546) (By similarity), Involved in the regulation of the endogenous content of polyunsaturated PI and PS lipids in the nervous system, Changes in these lipids extend to downstream metabolic products like PI phosphates PIP and PIP2, which play fundamental roles in cell biology (By similarity), Regulates mitochondrial morphology (PubMed:24599962), These dynamic changes may be due to PA hydrolysis at the mitochondrial surface (PubMed:24599962), May play a regulatory role in spermatogenesis or sperm function (PubMed:24599962)


This is Microcephalin protein, from Human, contains 835 amino acids, is soluble, locates in Cytoplasm.

Implicated in chromosome condensation and DNA damage induced cellular responses, May play a role in neurogenesis and regulation of the size of the cerebral cortex


This is Transcription factor SPT20 homolog protein, from Human, contains 779 amino acids, locates in Nucleus.

Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation, Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity), Required for starvation-induced ATG9A trafficking during autophagy


This is Interleukin-27 subunit alpha protein, from Human, contains 243 amino acids, is soluble, locates in Extracellular.

Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity, IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells, Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17), It drives rapid clonal expansion of naive but not memory CD4 T-cells, It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction, IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation, It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways, It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment, It suppresses the expression of GATA3, the inhibitor TH1 cells development, In CD8 T-cells, it activates STATs as well as GZMB, IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production, Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells, While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1, IL-27 has also an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3, Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells, Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9, In vein endothelial cells, it induces IRF1/interferon regulatory factor 1 and increase the expression of MHC class II transactivator/CIITA with resulting up-regulation of major histocompatibility complex class II, IL-27 also demonstrates antiviral activity with inhibitory properties on HIV-1 replication


This is Nucleoporin NUP35 protein, from Human, contains 326 amino acids, is membrane-bound, locates in Nucleus.

Functions as a component of the nuclear pore complex (NPC), NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors, May play a role in the association of MAD1 with the NPC


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 1 protein, from Human, contains 955 amino acids, has 6 Ig-like Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity), Plays a role in the formation or maintenance of inhibitory synapses, May function by inhibiting the activity of NLGN2


This is Protein DBF4 homolog B protein, from Human, contains 615 amino acids, has 1 DBF4-type Zinc finger, locates in Nucleus.

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation, Required for progression of S and M phases, The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle


This is Inositol polyphosphate multikinase protein, from Human, contains 416 amino acids, locates in Nucleus.

Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931), Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30624931), Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (PubMed:12223481), Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3-phospho-1D-myo-inositol 3,4,5-trisphosphate (PubMed:30420721, PubMed:28882892), Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6), Binding of these highly phosphorylated inositol phosphates to MLKL mediates the release of an N-terminal auto-inhibitory region, leading to activation of the kinase, Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610), Required for normal embryonic development, probably via its role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) and inositol hexakisphosphate (InsP6) (By similarity)

Belongs to the inositol phosphokinase (IPK) family


This is Atlastin-2 protein, from Human, contains 583 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes, Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily


This is Putative phospholipase B-like 2 protein, from Human, contains 589 amino acids, is soluble, locates in Lysosome/Vacuole.

Belongs to the phospholipase B-like family


This is Centrosomal protein of 70 kDa protein, from Human, contains 597 amino acids, is soluble, locates in Cytoplasm.

Plays a role in the organization of both preexisting and nascent microtubules in interphase cells, During mitosis, required for the organization and orientation of the mitotic spindle


This is Protein NEDD1 protein, from Human, contains 660 amino acids, is soluble, locates in Cytoplasm.

Required for mitosis progression, Promotes the nucleation of microtubules from the spindle


This is Rhox homeobox family member 1 protein, from Human, contains 184 amino acids, locates in Nucleus.

Transcription factor maybe involved in reproductive processes, Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis

Belongs to the paired-like homeobox family, PEPP subfamily


This is Transcription factor MafA protein, from Human, contains 353 amino acids, locates in Nucleus.

Transcription factor that activates insulin gene expression (PubMed:15993959, PubMed:12011435), Acts synergistically with NEUROD1/BETA2 and PDX1 (PubMed:15993959), Binds the insulin enhancer C1/RIPE3b element (PubMed:12011435), Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (PubMed:23148532, PubMed:29339498)

Belongs to the bZIP family, Maf subfamily


This is WD repeat-containing protein 36 protein, from Human, contains 951 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome, Involved in the nucleolar processing of SSU 18S rRNA (PubMed:34516797, PubMed:21051332), Involved in T-cell activation and highly coregulated with IL2 (PubMed:15177553)


This is Atypical kinase COQ8A, mitochondrial protein, from Human, contains 647 amino acids, is membrane-bound, locates in Mitochondrion.

Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294), Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294), Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294), Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144)

Belongs to the protein kinase superfamily, ADCK protein kinase family


This is Acetylxylan esterase A protein, from Soft rot fungus, contains 382 amino acids, is soluble, locates in Extracellular.

Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone

Belongs to the carbohydrate esterase 1 (CE1) family, AxeA subfamily


This is Aorsin protein, from Yellow koji mold, contains 652 amino acids, is soluble, locates in Extracellular.

Serine endopeptidase which hydrolyzes a range of fluorogenic peptide substrates containing the basic residues arginine or lysine at the P1 position and prefers paired basic resides, Also hydrolyzes clupeine and salmine, activates plasminogen and converts trypsinogen to trypsin


This is Tyrosine-protein kinase receptor TYRO3 protein, from African clawed frog, contains 880 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

May be involved in cell adhesion processes, particularly in the central nervous system

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Pre-B-cell leukemia transcription factor 1 protein, from African clawed frog, contains 347 amino acids, locates in Nucleus.

Acts as a transcriptional activator in complex with isoform 2 of meis1, to induce posterior neural and neural crest gene expression, and thereby specify hindbrain and neural crest cell fate, Binds to a highly conserved region in the promoter of the neural crest gene zic3, Required for the nuclear transport or retention of isoform 2 of meis1


This is Muscarinic toxin 7 protein, from Eastern green mamba, contains 86 amino acids, is soluble, locates in Extracellular.

Binds specifically and irreversibly to an allosteric site of the muscarinic acetylcholine M1 receptor (CHRM1) at subnanomolar concentrations and shows a very slow dissociation rate (PubMed:11562434, PubMed:10799315, PubMed:12488533, PubMed:21557730), It also inhibits agonist-mediated guanosine 5'-O-(3'-thiotriphosphate) (GTP-g-S) binding and downstream signaling, and decreases the dissociation rate of orthosteric antagonists (N-methylscopolamine (NMS) or pirenzepine) (PubMed:10799315, PubMed:15033377), Is a potent negative allosteric modulator (NAM) for CHRM1 activation and a positive allosteric modulator (PAM) for antagonist binding (Probable)

Belongs to the snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily


This is Integrator complex subunit 13 protein, from Mouse, contains 732 amino acids, is soluble, locates in Cytoplasm.

Crucial regulator of the mitotic cell cycle and development, At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling, At G2/M phase, may be required for proper spindle formation and execution of cytokinesis, Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing


This is Protein FEV protein, from Mouse, contains 237 amino acids, locates in Nucleus.

Functions as a transcriptional regulator, May function as a transcriptional repressor, Functions in the differentiation and the maintenance of the central serotonergic neurons, May play a role in cell growth


This is PRELI domain-containing protein 1, mitochondrial protein, from Mouse, contains 217 amino acids, is soluble, locates in Mitochondrion.

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes, In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane, Regulates the mitochondrial apoptotic pathway in primary Th cells, Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number, May be important for the development of vital and immunocompetent organs (By similarity)


This is Palmitoyltransferase ZDHHC3 protein, from Mouse, contains 299 amino acids, is membrane-bound, locates in Golgi apparatus.

May also function as a calcium transporter

Belongs to the DHHC palmitoyltransferase family


This is T-cell immunoglobulin and mucin domain-containing protein 2 protein, from Mouse, contains 305 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090), Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823), Plays also an important role in the regulation of Th2 immunity (PubMed:16043519), Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982)

Belongs to the immunoglobulin superfamily, TIM family


This is Nuclear receptor ROR-beta protein, from Mouse, contains 470 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina, Regulates the expression of PTF1A synergistically with FOXN4

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Torsin-2A protein, from Mouse, contains 321 amino acids, is soluble, locates in Endoplasmic reticulum.

Belongs to the ClpA/ClpB family, Torsin subfamily


This is Angiopoietin-like protein 8 protein, from Mouse, contains 198 amino acids, is soluble, locates in Extracellular.

Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577, PubMed:24043787), May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (PubMed:24043787), According to a report, may act by promoting ANGPTL3 cleavage (PubMed:23150577), According to another study, not required for cleavage of ANGPTL3 (PubMed:24043787)


This is Zinc finger protein 830 protein, from Mouse, contains 363 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

May play a role in pre-mRNA splicing as component of the spliceosome (By similarity), Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity (PubMed:21191184, PubMed:23213458, PubMed:25168238, PubMed:15988037), During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation (PubMed:21191184), Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells (PubMed:23213458), During the embryo preimplantation, controls different aspects of M phase (PubMed:15988037), During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (PubMed:25168238)


This is Sodium-coupled neutral amino acid transporter 4 protein, from Mouse, contains 547 amino acids, is membrane-bound, locates in Cell membrane.

Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:12537539, PubMed:23451088, PubMed:23301202), The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:12537539), Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (By similarity)

Belongs to the amino acid/polyamine transporter 2 family


This is NAD-dependent protein lipoamidase sirtuin-4, mitochondrial protein, from Mouse, contains 333 amino acids, is soluble, locates in Mitochondrion.

Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed:19220062), Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications, Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879), Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity, Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573), In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782), Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782), Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (PubMed:23746352), Does not seem to deacetylate PC (PubMed:23438705), Controls fatty acid oxidation by inhibiting PPARA transcriptional activation, Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310, PubMed:20685656), Down-regulates insulin secretion (By similarity)

Belongs to the sirtuin family, Class II subfamily


This is Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 protein, from Mouse, contains 323 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase

Belongs to the fatty acid desaturase type 1 family, DEGS subfamily


This is Coiled-coil domain-containing protein 80 protein, from Mouse, contains 949 amino acids, is soluble, locates in Extracellular.

Promotes cell adhesion and matrix assembly


This is HMG box-containing protein 1 protein, from Mouse, contains 516 amino acids, locates in Nucleus.

Transcriptional repressor that binds to the promoter region of target genes, Plays a role in the regulation of the cell cycle and of the Wnt pathway, Binds preferentially to the sequence 5'-TTCATTCATTCA-3', Binding to the histone H1,0 promoter is enhanced by interaction with RB1, Disrupts the interaction between DNA and TCF4 (By similarity)


This is Lysophospholipid acyltransferase 2 protein, from Mouse, contains 519 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acyltransferase which catalyzes the transfert of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18287005, PubMed:29196633), Catalyzes the acylation of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) and to a lesser extend lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) (PubMed:18287005, PubMed:29196633), Does not acylates lysophosphatidic acid (LPA) and lysophosphatidylserine (PubMed:18287005), Prefers oleoyl-CoA as the acyl donor (PubMed:18287005, PubMed:29196633), May be involved in chondrocyte differentiation (PubMed:29196633)

Belongs to the membrane-bound acyltransferase family


This is Pentatricopeptide repeat-containing protein 2, mitochondrial protein, from Mouse, contains 381 amino acids, locates in Mitochondrion.

Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function


This is Ribosome quality control complex subunit TCF25 protein, from Mouse, contains 676 amino acids, locates in Nucleus.

Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity), In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (By similarity), Also acts as a transcriptional repressor: represses transcription of SRF in vitro and so may play a role in heart development (By similarity), May play a role in cell death control (PubMed:18068114)


This is Melanopsin protein, from Rat, contains 474 amino acids, is membrane-bound, locates in Cell membrane.

Photoreceptor that binds cis-retinaldehydes (By similarity), Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (By similarity), May be involved in the optokinetic visual tracking response (By similarity), May be involved in the regulation of retinal hyaloid vessel growth and regression (By similarity)

Belongs to the G-protein coupled receptor 1 family, Opsin subfamily


This is Lactoperoxidase protein, from Golden hamster, contains 710 amino acids, is soluble, locates in Extracellular.

Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2), Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity), Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism, May be implicated in airway host defense against infection (By similarity), May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity)

Belongs to the peroxidase family, XPO subfamily


This is DNA replication factor Cdt1 protein, from Mouse, contains 557 amino acids, locates in Nucleus.

Required for both DNA replication and mitosis, DNA replication licensing factor, required for pre-replication complex assembly, Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC), Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity), Potential oncogene (PubMed:11850834)


This is Netrin-G2 protein, from Mouse, contains 589 amino acids, is membrane-bound, locates in Cell membrane.

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels, Promotes neurite outgrowth of both axons and dendrites


This is Netrin-G1 protein, from Mouse, contains 539 amino acids, is membrane-bound, locates in Cell membrane.


This is Neuropilin and tolloid-like protein 1 protein, from Mouse, contains 533 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the development and/or maintenance of neuronal circuitry, Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density, Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory


This is Citramalyl-CoA lyase, mitochondrial protein, from Mouse, contains 338 amino acids, locates in Mitochondrion.

Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism (PubMed:29056341), Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (By similarity), The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed:29056341), Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (By similarity), Also displays malyl-CoA thioesterase activity, Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (By similarity), Also has very weak citramalate synthase activity in vitro (By similarity)

Belongs to the HpcH/HpaI aldolase family, Citrate lyase beta subunit-like subfamily


This is Myb-related transcription factor, partner of profilin protein, from Mouse, contains 393 amino acids, locates in Nucleus.

Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3', Dimerization with PFN1 reduces its DNA-binding capacity


This is Alkaline ceramidase 1 protein, from Mouse, contains 273 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:12783875), Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875), Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:12783875), May also hydrolyze dihydroceramides to produce dihydrosphingosine (By similarity), ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:27126290, PubMed:29056331)

Belongs to the alkaline ceramidase family


This is Mitofusin-1 protein, from Rat, contains 741 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:14561718, PubMed:12589796), Membrane clustering requires GTPase activity, It may involve a major rearrangement of the coiled coil domains (By similarity), Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:14561718), Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:14561718), Has low GTPase activity (By similarity)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, Mitofusin subfamily


This is Mitofusin-2 protein, from Rat, contains 757 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:14561718, PubMed:15322553, PubMed:12589796, PubMed:12598526), Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events, Overexpression induces the formation of mitochondrial networks, Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity), Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (PubMed:12598526), Plays an important role in the regulation of vascular smooth muscle cell proliferation (PubMed:15322553), Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy), Is required for PRKN recruitment to dysfunctional mitochondria (By similarity), Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity), Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity)


This is Ankyrin repeat domain-containing protein 1 protein, from Rat, contains 319 amino acids, locates in Nucleus.

May play an important role in endothelial cell activation, May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes


This is Serine carboxypeptidase-like 8 protein, from Mouse-ear cress, contains 433 amino acids, locates in Lysosome/Vacuole.

Involved in plants secondary metabolism, Functions as acyltransferase to form the sinapate ester sinapoylmalate, Also capable of catalyzing the formation of 1,2-bis-O-sinapoyl beta-D-glucoside


This is Acyl-CoA-binding domain-containing protein 5 protein, from Mouse-ear cress, contains 648 amino acids, is soluble, locates in Cytoplasm.

Binds medium- and long-chain acyl-CoA esters with very high affinity, Can interact in vitro with oleoyl-CoA, barely with palmitoyl-CoA, but not with arachidonyl-CoA, May function as an intracellular carrier of acyl-CoA esters (By similarity)


This is Protein ACTIVITY OF BC1 COMPLEX KINASE 1, chloroplastic protein, from Mouse-ear cress, contains 682 amino acids, is soluble, locates in Plastid.

Kinase that can phosphorylate the tocopherol cyclase VTE1, a key enzyme of tocopherol (vitamin E) metabolism and involved in the recycling of oxidated alpha-tocopherol quinone, possibly stabilizing it at plastoglobules, Regulates also plastoglobule protein composition (PubMed:24267661), Prevents photodamage of chloroplasts under continuous red light, thus working in opposition to ABC1K3 (PubMed:25882344), Together with ABC1K1, contributes to plastoglobule (PG) function in prenyl-lipid metabolism, stress response, and thylakoid remodeling (PubMed:23673981, PubMed:24267661), Involved in chlorophyll degradation and in the maintenance of the number of chlorophyll-binding photosynthetic thylakoid membranes (PubMed:22447966), Ensures photosynthetic electron transport by regulating the homeostasis of plastoquinone, beta-carotene and xanthophyll lutein, as well as membrane antioxidant tocopherol metabolism (PubMed:24267661), Seems to affect specifically stability or turnover of D1 protein, product of psbA, one of the four core subunits of the photosystem II (PSII) (PubMed:25882344), Required for photooxidative stress responses, including the induction of oxidative stress response genes (e,g, FSD1, CSD1, CAT1, and UTG71C1), to prevent photosystem II core and chlorophyll degradations (PubMed:22447966, PubMed:23673981, PubMed:24267661)

Belongs to the protein kinase superfamily, ADCK protein kinase family


This is Protein high chlorophyll fluorescent 107 protein, from Mouse-ear cress, contains 652 amino acids, is membrane-bound, locates in Plastid.

Involved, directly or indirectly, in the processing of chloroplast encoded mRNAs, Exhibits sequence-specific RNA binding and RNA remodeling activities, probably leading to the activation of translation of the target gene cluster psbB-psbT-psbH-petB-petD (PubMed:22451905), Blocks 5'-3' and 3'-5' exoribonucleases (e,g, polynucleotide phosphorylase (PNPase), RNase R) in vitro (PubMed:22451905), Necessary for intercistronic RNA processing of the psbH 5' untranslated region or the stabilization of 5' processed psbH RNAs, Also required for the synthesis of psbB (PubMed:11549768, PubMed:15918885, PubMed:22451905)


This is Nuclear pore complex protein NUP58 protein, from Mouse-ear cress, contains 513 amino acids, locates in Nucleus.

Involved in nucleocytoplasmic trafficking, May have regulatory roles in the gibberellin pathway, in auxin signaling and in light perception


This is Increased DNA methylation 2 protein, from Mouse-ear cress, contains 349 amino acids, is soluble, locates in Nucleus.

Prevents DNA hypermethylation and transcriptional silencing of transgenes and of some endogenous genes (PubMed:25002145, PubMed:24920332), May act as a molecular chaperone of IDM1, regulating its H3K18 acetylation activity (PubMed:25002145, PubMed:24920332)

Belongs to the small heat shock protein (HSP20) family


This is Serine/threonine-protein kinase STY17 protein, from Mouse-ear cress, contains 570 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine protein kinase that specifically phosphorylates chloroplast precursor proteins in the cytosol within the cleavable presequences (transit peptides), May be part of a cytosolic regulatory network involved in chloroplast protein import, Does not phosphorylate mitochondrion precursor proteins, Specific for ATP and does not utilize other NTPs (PubMed:17090544, PubMed:16429265), Plays a role in chloroplast biogenesis and differentiation in cotyledons, possibly through phosphorylation of chloroplast preproteins (PubMed:21799034)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Transmembrane emp24 domain-containing protein p24delta5 protein, from Mouse-ear cress, contains 216 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vesicular protein trafficking, Mainly functions in the early secretory pathway, Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity), Interacts with p24beta2 at endoplasmic reticulum export sites for endoplasmic reticulum exit and coupled transport to the Golgi apparatus, Once in the Golgi, interacts very efficiently with the COPI machinery for retrograde transport back to the endoplasmic reticulum


This is Ubiquitin-like-specific protease 1C protein, from Mouse-ear cress, contains 571 amino acids, is soluble, locates in Nucleus.

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins, Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5, Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3, Protease activity mainly directed at deconjugating SUM1 and SUM2 from their target proteins, Regulates salt stress responses and flowering time, Redundant with ULP1D


This is Glycine-rich RNA-binding protein RZ1C protein, from Mouse-ear cress, contains 310 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

Binds RNA and DNA sequences non-specifically, May be involved in tolerance to cold stress


This is Dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial protein, from Mouse-ear cress, contains 539 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Belongs to the 2-oxoacid dehydrogenase family


This is U11/U12 small nuclear ribonucleoprotein 65 kDa protein protein, from Mouse-ear cress, contains 442 amino acids, locates in Nucleus.

Component of minor spliceosome required for U12-type intron splicing and alternative splicing of many introns, Binds specifically to U12 snRNA, which is necessary for branch-point site recognition, Required for normal plant development


This is G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 protein, from Mouse-ear cress, contains 821 amino acids, is membrane-bound, locates in Cell membrane.


This is Auxin efflux carrier component 4 protein, from Mouse-ear cress, contains 616 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a component of the auxin efflux carrier, Plays a role in generating a sink for auxin into columella cells (PubMed:20439545), Maintains the endogenous auxin gradient, which is essential for correct root patterning (PubMed:20439545), Involved in EXO70A3-regulated gravitropic responses in columella cells and in root system architecture (RSA) (PubMed:31299202)

Belongs to the auxin efflux carrier (TC 2,A,69,1) family


This is Hydroxyproline O-galactosyltransferase GALT5 protein, from Mouse-ear cress, contains 672 amino acids, is membrane-bound, locates in Golgi apparatus.

Possesses hydroxyproline O-galactosyltransferase activity, Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs), Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues, Utilizes UDP-galactose solely as sugar donor, The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition, AGP glycans play essential roles in both vegetative and reproductive plant growth

Belongs to the glycosyltransferase 31 family


This is Protein NRT1/ PTR FAMILY 2.13 protein, from Mouse-ear cress, contains 620 amino acids, is membrane-bound, locates in Cell membrane.

Low-affinity proton-dependent nitrate transporter, Not involved in dipeptides transport, but has a weak glucosinolate transport activity, Involved in phloem loading and nitrate remobilization from the older leaves to other tissues

Belongs to the major facilitator superfamily, Proton-dependent oligopeptide transporter (POT/PTR) (TC 2,A,17) family


This is Peptide chain release factor APG3, chloroplastic protein, from Mouse-ear cress, contains 422 amino acids, locates in Plastid.

May direct the termination of translation in response to the peptide chain termination codon UAG, Required for normal chloroplast development and plays essential roles in the termination of translation in plastids

Belongs to the prokaryotic/mitochondrial release factor family


This is Alpha-galactosidase 2 protein, from Mouse-ear cress, contains 396 amino acids, is soluble, locates in Extracellular.

May regulate leaf (and possibly other organ) development by functioning in cell wall loosening and cell wall expansion

Belongs to the glycosyl hydrolase 27 family


This is Protein BREAST CANCER SUSCEPTIBILITY 1 homolog protein, from Mouse-ear cress, contains 941 amino acids, has 1 RING-type Zinc finger, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type; degenerate Zinc finger, locates in Nucleus.

RING-type

C2HC pre-PHD-type

PHD-type; degenerate

Plays a role in DNA repair and in cell-cycle control, Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR)


This is E3 ubiquitin-protein ligase BRE1-like 1 protein, from Mouse-ear cress, contains 878 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1, H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me, It thereby plays a central role in histone code and gene regulation, Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6, Required for the regulation of flowering time and defense against necrotrophic fungal pathogens (PubMed:12535538, PubMed:17329565, PubMed:17329563, PubMed:19286969), Involved in the control of seed dormancy and germination (PubMed:21799800)


This is 4-alpha-glucanotransferase DPE2 protein, from Mouse-ear cress, contains 955 amino acids, is soluble, locates in Cytoplasm.

Cytosolic alpha-glucanotransferase essential for the cytosolic metabolism of maltose, an intermediate on the pathway by which starch is converted to sucrose in leaves at night, Metabolizes maltose exported from the chloroplast and is specific for beta-maltose, May play a role in freezing tolerance, Temperature drop induces inactivation of DPE2 that leads to rapid accumulation of maltose, a solute that protects cells from freezing damage

Belongs to the disproportionating enzyme family


This is Sialyltransferase-like protein 2 protein, from Mouse-ear cress, contains 440 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in the transfer of 2-keto-3-deoxy-D-lyxo-heptulosaric acid (Dha) and/or 2-keto-3-deoxy-D-manno-octulosonic acid (Kdo) on the homogalacturonan backbone of rhamnogalacturonan-II, Required for efficient pollen grain germination and pollen tube elongation (PubMed:24825296), Does not possess sialyltransferase activity in vitro (PubMed:19470101)

Belongs to the glycosyltransferase 29 family


This is Inactive poly [ADP-ribose] polymerase RCD1 protein, from Mouse-ear cress, contains 589 amino acids, is soluble, locates in Nucleus.

Inactive ADP-ribosyltransferase that functions with SRO1 to regulate oxidative stress, hormonal and developmental responses, Required for embryogenesis, vegetative and reproductive development, and abiotic stress responses, May regulate several stress-responsive genes, Seems to play a larger developmental role than SRO1, Does not bind NAD in vitro


This is Protein NSP-INTERACTING KINASE 2 protein, from Mouse-ear cress, contains 635 amino acids, is membrane-bound, locates in Cell membrane.

Involved in defense response to geminivirus infection (By similarity), Phosphorylates RPL10A in vitro


This is Protein BRASSINAZOLE-RESISTANT 1 protein, from Mouse-ear cress, contains 336 amino acids, locates in Nucleus.

Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5'-CGTG(T/C)G-3' in gene promoter, Regulates positively the brassinosteroid-signaling pathway (PubMed:33324437), Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis, Promotes growth, Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e,g, HLL, ANT, and AP2), Regulates negatively the abscisic acid (ABA) signaling pathway during the post-germination stage (PubMed:33324437)


This is Hydroxyisourate hydrolase protein, from Soybean, contains 560 amino acids, is membrane-bound, locates in Peroxisome.

Involved in the conversion of hydroxyisourate to ureides such as allantoin, the major form of nitrogen transport in legumes

Belongs to the glycosyl hydrolase 1 family


This is Kinesin-like protein KIN-7A protein, from Mouse-ear cress, contains 974 amino acids, is soluble, locates in Cytoplasm.

Probable plus end-directed motor protein that functions in the NACK-PQR (ANP1-MKK6-MPK4) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion, Regulates the activity and the localization of ANP1, probably by association through the non-catalytic region of the kinase, Functionally redundant with NACK2 and essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during microgametogenesis and megagametogenesis

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIN-7 subfamily


This is Solanesyl diphosphate synthase 1, chloroplastic protein, from Mouse-ear cress, contains 406 amino acids, locates in Endoplasmic reticulum.

Involved in providing solanesyl diphosphate for plastoquinone-9 (PQ-9) formation in plastids (PubMed:12437513, PubMed:23913686, PubMed:26039552), Catalyzes the elongation of the prenyl side chain of PQ-9 in plastids (PubMed:23913686, PubMed:26039552), Contributes to the biosynthesis of plastochromanol-8 (PC-8) in plastids (PubMed:23913686, PubMed:26039552), Does not contribute to the synthesis of tocopherol or ubiquinone (PubMed:23913686), PQ-9 and PC-8 are lipophilic antioxidants that act as protectant against photooxidative stress under high light stress conditions (PubMed:23913686, PubMed:26039552, PubMed:29901834), Prefers geranylgeranyl diphosphate to farnesyl diphosphate as substrate (PubMed:12437513), No activity with geranyl diphosphate or dimethylallyl diphosphate as substrate (PubMed:12437513)


This is Zinc finger protein VAR3, chloroplastic protein, from Mouse-ear cress, contains 758 amino acids, has 2 RanBP2-type Zinc finger, locates in Plastid.

Probable component of some protein complex required for chloroplast and palisade cell development (PubMed:15340011), Involved in C-to-U editing of chloroplastic RNA, Controls a large number of chloroplastic editing sites, Binds the editing recognition trans-factors PCMP-H51/CRR28 and PCMP-H12/OTP82 (PubMed:25768119)


This is Polycomb protein PHO protein, from Fruit fly, contains 520 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is Cell death abnormality protein 12 protein, from Caenorhabditis elegans, contains 731 amino acids, is soluble, locates in Cytoplasm.

Involved in programmed apoptosis and necrosis, Required for the cell corpse engulfment process, Has roles in the formation of actin halos and distal tip cell migration (PubMed:11703939, PubMed:11703940, PubMed:11146658, PubMed:11595183, PubMed:14645848, PubMed:15620647, PubMed:15247908, PubMed:15744306, PubMed:21490059), Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body (PubMed:26292279), Plays no role in amphid axon outgrowth (PubMed:12297102)


This is Gametocyte-specific factor 1 homolog protein, from Fruit fly, contains 167 amino acids, has 2 CHHC U11-48K-type Zinc finger, locates in Nucleus.

CHHC U11-48K-type

CHHC U11-48K-type

Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons, Required for repression of transposons and neighboring genes in ovarian somatic and germline cells


This is Protein nutcracker protein, from Fruit fly, contains 314 amino acids, is soluble, locates in Cytoplasm.

Functions together with PI31 to control non-apoptotic caspase activation during sperm individualization, Positively regulates PI31 stability


This is Protein insensitive protein, from Fruit fly, contains 376 amino acids, locates in Nucleus.

Can act as both a transcriptional repressor and corepressor, Represses the expression of genes involved in neural development and preferentially binds palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495, PubMed:23468431), Acts as a corepressor for suppressor of hairless (Su(H)) and inhibits Notch signaling during peripheral nervous system development (PubMed:21765394, PubMed:25561495)


This is O-glucosyltransferase rumi protein, from Fruit fly, contains 411 amino acids, is soluble, locates in Endoplasmic reticulum.

Protein O-glucosyltransferase, Catalyzes the reaction that attaches glucose through an O-glycosidic linkage to a conserved serine residue found in the consensus sequence C-X-S-X-[PA]-C in epidermal growth factor-like repeats (PubMed:27428513), Regulates Notch signaling by glucosylating Notch in the ER, glucosylation is required for the correct folding and cleavage of Notch

Belongs to the glycosyltransferase 90 family


This is Kinesin-related protein 5 protein, from Social amoeba, contains 990 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated force-producing protein that plays a role in organelle transport, Its motor activity is directed toward the microtubule's plus end (By similarity), May connect microtubules to actin filaments, Associates with actin-based structures in cells and is likely involved in the organization of actin cytoskeletons in such structures

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin subfamily


This is [Skp1-protein]-hydroxyproline N-acetylglucosaminyltransferase protein, from Social amoeba, contains 423 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the attachment of N-acetylglucosamine (GlcNAc) in alpha-linkage onto the 'hydroxyPro-143' residue of Skp1 (fpaA/fpaB), Is the first glycosyltransferase in the Skp1 HyPro modification pathway, which results in a pentasaccharide-linked 'HyPro-143'

Belongs to the glycosyltransferase 60 family


This is Na(+)/H(+) exchanger protein 2 protein, from Caenorhabditis elegans, contains 644 amino acids, is membrane-bound, locates in Cell membrane.

Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis, Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept-1, May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release, May play a role in the regulation of lifespan independent of the stress response pathway

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2,A,36) family


This is LDLR chaperone boca protein, from Fruit fly, contains 180 amino acids, locates in Endoplasmic reticulum.

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs), Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway


This is Josephin-2 protein, from Human, contains 188 amino acids, is soluble, locates in Cytoplasm.

Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro), May act as a deubiquitinating enzyme


This is Smad nuclear-interacting protein 1 protein, from Human, contains 396 amino acids, locates in Nucleus.

Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106), As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable), Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding, Involved in the microRNA (miRNA) biogenesis, May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA


This is Serine/threonine-protein kinase Kist protein, from Human, contains 419 amino acids, locates in Nucleus.

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase, May be involved in trafficking and/or processing of RNA (By similarity)


This is Fibroblast growth factor-binding protein 3 protein, from Human, contains 258 amino acids, is soluble, locates in Extracellular.

Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability

Belongs to the fibroblast growth factor-binding protein family


This is Mucin-7 protein, from Human, contains 377 amino acids, is soluble, locates in Extracellular.

May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing, Binds P,aeruginosa pili


This is Gasdermin-B protein, from Human, contains 416 amino acids, is soluble, locates in Cytoplasm.

Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death and specifically mediates cell death of Gram-negative bacteria in response to infection (PubMed:34022140), Following cleavage and activation by granzyme A (GZMA), the N-terminal part recognizes and binds phospholipids found on Gram-negative bacterial membranes, such as lipid A and cariolipin, homooligomerizes within the bacterial membranes and forms pores, triggering cell death (PubMed:34022140), In contrast to isoform 4, does not bind to membrane inner leaflet lipids of host human cell, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate (PubMed:34022140)


This is Iron-sulfur protein NUBPL protein, from Human, contains 319 amino acids, locates in Mitochondrion.

Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), May deliver of one or more Fe-S clusters to complex I subunits

Belongs to the Mrp/NBP35 ATP-binding proteins family


This is Adenosine 3'-phospho 5'-phosphosulfate transporter 1 protein, from Human, contains 432 amino acids, is membrane-bound, locates in Golgi apparatus.

Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes, Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment

Belongs to the nucleotide-sugar transporter family, SLC35B subfamily


This is Protein NDNF protein, from Human, contains 568 amino acids, is soluble, locates in Extracellular.

Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645), Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645), Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645), May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645), Also regulates extracellular matrix assembly and cell adhesiveness (By similarity), Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764)


This is Golgin subfamily A member 5 protein, from Human, contains 731 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in maintaining Golgi structure, Stimulates the formation of Golgi stacks and ribbons, Involved in intra-Golgi retrograde transport


This is Probable cationic amino acid transporter protein, from Human, contains 771 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Belongs to the amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2,A,3,3) family


This is Bromo adjacent homology domain-containing 1 protein protein, from Human, contains 780 amino acids, locates in Nucleus.

Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains, May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1, Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins, At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3


This is DnaJ homolog subfamily B member 14 protein, from Human, contains 379 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744)

Belongs to the DnaJ family, DNAJB12/DNAJB14 subfamily


This is tRNA methyltransferase 10 homolog A protein, from Human, contains 339 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765), Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678)

Belongs to the class IV-like SAM-binding methyltransferase superfamily, TRM10 family


This is Retinol dehydrogenase 11 protein, from Human, contains 318 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Retinol dehydrogenase with a clear preference for NADP, Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696), Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448), Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is POC1 centriolar protein homolog B protein, from Human, contains 478 amino acids, is soluble, locates in Cytoplasm.

Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285), Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428), Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285), Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594), Required for retinal integrity (PubMed:25044745)


This is Placental protein 13-like protein, from Human, contains 139 amino acids, locates in Nucleus.

Binds beta-galactoside and lactose, Strong inducer of T-cell apoptosis


This is F-box only protein 25 protein, from Human, contains 367 amino acids, locates in Nucleus.

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity)


This is Anterior gradient protein 3 protein, from Human, contains 166 amino acids, locates in Endoplasmic reticulum.

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway, Might be involved in the regulation of intracellular calcium in tracheal epithelial cells


This is Protein MGARP protein, from Human, contains 240 amino acids, is membrane-bound, locates in Mitochondrion.

Plays a role in the trafficking of mitochondria along microtubules, Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia, Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion, Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity), Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons (By similarity)


This is ATP-dependent RNA helicase DDX54 protein, from Human, contains 881 amino acids, locates in Nucleus.

Has RNA-dependent ATPase activity, Represses the transcriptional activity of nuclear receptors

Belongs to the DEAD box helicase family, DDX54/DBP10 subfamily


This is Potassium voltage-gated channel subfamily G member 4 protein, from Human, contains 519 amino acids, is membrane-bound, locates in Cell membrane.

Potassium channel subunit that does not form functional channels by itself, Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135)

Belongs to the potassium channel family, G (TC 1,A,1,2) subfamily, Kv6,4/KCNG4 sub-subfamily


This is Hydroxycarboxylic acid receptor 2 protein, from Human, contains 363 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase, This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet, Mediates nicotinic acid-induced apoptosis in mature neutrophils, Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis, The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide

Belongs to the G-protein coupled receptor 1 family


This is G-protein coupled bile acid receptor 1 protein, from Human, contains 330 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for bile acid, Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production, May be involved in the suppression of macrophage functions by bile acids


This is Pantothenate kinase 1 protein, from Human, contains 598 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis

Belongs to the type II pantothenate kinase family


This is Epidermal growth factor receptor kinase substrate 8-like protein 3 protein, from Human, contains 593 amino acids, is soluble, locates in Cytoplasm.


This is Epidermal growth factor receptor kinase substrate 8-like protein 1 protein, from Human, contains 723 amino acids, is soluble, locates in Cytoplasm.

Stimulates guanine exchange activity of SOS1, May play a role in membrane ruffling and remodeling of the actin cytoskeleton


This is Grainyhead-like protein 3 homolog protein, from Human, contains 626 amino acids, locates in Nucleus.

Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity), Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468), xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity), Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others, Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury, Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation, Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity), Also required for proper development of the oral periderm (PubMed:24360809), No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122)

Belongs to the grh/CP2 family, Grainyhead subfamily


This is 2-phosphoxylose phosphatase 1 protein, from Human, contains 480 amino acids, is membrane-bound, locates in Golgi apparatus.

Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains, Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases, Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains

Belongs to the histidine acid phosphatase family


This is U3 small nucleolar RNA-associated protein 15 homolog protein, from Human, contains 518 amino acids, locates in Nucleus.

Ribosome biogenesis factor, Involved in nucleolar processing of pre-18S ribosomal RNA, Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)


This is Glucose-6-phosphate exchanger SLC37A2 protein, from Human, contains 501 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Inorganic phosphate and glucose-6-phosphate antiporter, May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction, Independent of a lumenal glucose-6-phosphatase, May not play a role in homeostatic regulation of blood glucose levels

Belongs to the major facilitator superfamily, Organophosphate:Pi antiporter (OPA) (TC 2,A,1,4) family


This is Membrane progestin receptor beta protein, from Human, contains 354 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432), Seems to act through a G(i) mediated pathway (PubMed:23763432), May be involved in oocyte maturation (By similarity), Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870)


This is Arginine/serine-rich protein PNISR protein, from Human, contains 805 amino acids, locates in Nucleus.

Belongs to the splicing factor SR family


This is Monocarboxylate transporter 10 protein, from Human, contains 515 amino acids, is membrane-bound, locates in Cell membrane.

Sodium- and proton-independent thyroid hormones and aromatic acids transporter (PubMed:11827462, PubMed:18337592, PubMed:28754537), Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (PubMed:18337592), Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11827462, PubMed:28754537), Plays an important role in homeostasis of aromatic amino acids (By similarity)

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is WAS/WASL-interacting protein family member 2 protein, from Human, contains 440 amino acids, is soluble, locates in Cytoplasm.

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors, Plays an important role in actin-microspike formation through cooperation with WASL, May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system


This is ATP-dependent 6-phosphofructokinase subunit beta protein, from Yeast, contains 941 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Belongs to the phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade 'E' sub-subfamily


This is Protein mab-21-like 2 protein, from Zebrafish, contains 359 amino acids, locates in Nucleus.

Required for eye morphogenesis, May promote the survival of proliferating retinal progenitor cells


This is Piwi-like protein 1 protein, from Zebrafish, contains 858 amino acids, is soluble, locates in Cytoplasm.

Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:14516689, PubMed:17418787, PubMed:18833190), Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:14516689, PubMed:17418787, PubMed:18833190), Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:14516689, PubMed:17418787, PubMed:18833190), Has a strong preference for piRNAs with a uridine nucleotide at their 5'-end (g1U preference, also named 1U-bias) and binds piRNAs in an opposite direction compared to piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190), Participates in a piRNA amplification loop with piwil2/zili (PubMed:14516689, PubMed:17418787, PubMed:18833190), Not involved in the piRNA amplification loop, also named ping-pong amplification cycle, Acts as an endoribonuclease that cleaves transposon messenger RNAs (By similarity)

Belongs to the argonaute family, Piwi subfamily


This is Protein BANP protein, from Mouse, contains 548 amino acids, locates in Nucleus.

Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function, Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer, Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels, Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth (PubMed:12494467)


This is F-box/WD repeat-containing protein 7 protein, from Mouse, contains 710 amino acids, is soluble, locates in Nucleus.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459, PubMed:22748924), Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:22748924), Mediates ubiquitination and subsequent degradation of CCNE1 and MYC (PubMed:22748924), Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, RICTOR and probably PSEN1 (By similarity), Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity), SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459), Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593), Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018), Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (By similarity), The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (By similarity)


This is CMRF35-like molecule 5 protein, from Mouse, contains 221 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

(Microbial infection) Acts as a functional murine norovirus (MNV) receptor, Primary determinant of MNV species tropism and is sufficient to render cells permissive to infection by MNV, Can render nonmurine mammalian cells susceptible to MNV infection (PubMed:27681626, PubMed:27540007)


This is Tubulin gamma-2 chain protein, from Mouse, contains 451 amino acids, is soluble, locates in Cytoplasm.

Tubulin is the major constituent of microtubules, The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)


This is Glycosaminoglycan xylosylkinase protein, from Mouse, contains 409 amino acids, is membrane-bound, locates in Golgi apparatus.

Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains, Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases, Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized


This is Keratin, type I cytoskeletal 25 protein, from Mouse, contains 446 amino acids, is soluble, locates in Cytoplasm.

Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (PubMed:14996088, PubMed:17920809), Plays a role in the cytoskeleton organization (By similarity)

Belongs to the intermediate filament family


This is Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 protein, from Mouse, contains 475 amino acids, is soluble, locates in Cytoplasm.

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity, Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process, Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons, May act by mediating protein-protein interactions during germ cell maturation


This is Sodium- and chloride-dependent transporter XTRP3A protein, from Mouse, contains 592 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15689184), Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A20 subfamily