This is HMG box-containing protein 1 protein, from Human, contains 514 amino acids, locates in Nucleus.

Transcriptional repressor that binds to the promoter region of target genes, Plays a role in the regulation of the cell cycle and of the Wnt pathway, Binds preferentially to the sequence 5'-TTCATTCATTCA-3', Binding to the histone H1,0 promoter is enhanced by interaction with RB1, Disrupts the interaction between DNA and TCF4


This is Cyclin-T1 protein, from Human, contains 726 amino acids, locates in Nucleus.

(Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA), Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes

Belongs to the cyclin family, Cyclin C subfamily


This is Selenoprotein F protein, from Human, contains 165 amino acids, is soluble, locates in Endoplasmic reticulum.

May be involved in redox reactions associated with the formation of disulfide bonds (By similarity), May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556), May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556)


This is Monocarboxylate transporter 2 protein, from Human, contains 478 amino acids, is membrane-bound, locates in Cell membrane.

Proton-coupled monocarboxylate symporter, Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:9786900, PubMed:32415067), Dimerization is functionally required and both subunits work cooperatively in transporting substrate (PubMed:32415067)

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is Cell cycle checkpoint protein RAD1 protein, from Human, contains 282 amino acids, locates in Nucleus.

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395), The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958), Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698), The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698), The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603), Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799)


This is Protein-S-isoprenylcysteine O-methyltransferase protein, from Human, contains 284 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Belongs to the class VI-like SAM-binding methyltransferase superfamily, Isoprenylcysteine carboxyl methyltransferase family


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 protein, from Human, contains 890 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084), Contributes to the native pacemaker currents in heart (If) and in neurons (Ih), May mediate responses to sour stimuli

Belongs to the potassium channel HCN family


This is Hematopoietic prostaglandin D synthase protein, from Human, contains 199 amino acids, is soluble, locates in Cytoplasm.

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates, Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide

Belongs to the GST superfamily, Sigma family


This is Polyglutamine-binding protein 1 protein, from Human, contains 265 amino acids, locates in Nucleus.

Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658), Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308), May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner, Can activate transcription directly or via association with the transcription machinery (PubMed:10198427), May be involved in ATXN1 mutant-induced cell death (PubMed:12062018), The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018), Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836), Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437), Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437)


This is Checkpoint protein HUS1 protein, from Human, contains 280 amino acids, locates in Cytoplasm.

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair, The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex, Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER), The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates, The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase


This is Nibrin protein, from Human, contains 754 amino acids, locates in Nucleus.

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity, The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis, The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, RAD50 may be required to bind DNA ends and hold them in close proximity, NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions, It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX, NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation, NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints, The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability, Forms a complex with RBBP8 to link DNA double-strand break sensing to resection, Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex


This is Serine/threonine-protein kinase 4 homolog A protein, from Social amoeba, contains 461 amino acids, is soluble, locates in Cytoplasm.

Regulates both cAMP signaling during early development and the stress response, Functions as an activator of adenylylcyclase

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily


This is Ovarian-specific serine/threonine-protein kinase Lok protein, from Fruit fly, contains 476 amino acids, locates in Nucleus.

May have a role in germline establishment

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CDS1 subfamily


This is Neurotoxin BmK-M10 protein, from Manchurian scorpion, contains 84 amino acids, is soluble, locates in Extracellular.

Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission, Administration to mice at a dosage of 0,8 mg/kg produces an analgesic effect

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily


This is Protein lap1 protein, from Caenorhabditis elegans, contains 699 amino acids, is membrane-bound, locates in Cell membrane.

Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells, Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells, Required for correct localization of ifb-2 intermediate filaments in the terminal web, Required for dlg-1 lateral localization (PubMed:18411252), With dlg-1, cooperatively regulates ajm-1 localization to apical junctions (PubMed:11715019)

Belongs to the LAP (LRR and PDZ) protein family


This is Serine protease gd protein, from Fruit fly, contains 531 amino acids, is soluble, locates in Extracellular.

Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:9618496, PubMed:9477324, PubMed:12493753), Three proteases; ndl, gd and snk process easter to create active easter (PubMed:9477324), Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo (PubMed:9477324)


This is Mitogen-activated protein kinase p38a protein, from Fruit fly, contains 366 amino acids, locates in Nucleus.

Kinase involved in a signal transduction pathway, May down-regulate insect immunity gene expression after prolonged infection

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily


This is UDP-galactose/UDP-glucose transporter 1 protein, from Mouse-ear cress, contains 332 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential sugar transporter required for the transport of UDP-galactose and UDP-glucose from the cytoplasm into the Golgi and the endoplasmic reticulum, to ensure quality control of protein folding, Essential for pollen development and involved in embryo sac progress

Belongs to the nucleotide-sugar transporter family, UDP-galactose:UMP antiporter (TC 2,A,7,11) subfamily


This is Metacaspase-4 protein, from Mouse-ear cress, contains 418 amino acids, is soluble, locates in Cytoplasm.

Cysteine protease that cleaves specifically after arginine or lysine residues, Does not cleave caspase-specific substrates, Plays a positive regulatory role in biotic and abiotic stress-induced programmed cell death


This is Thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial protein, from Mouse-ear cress, contains 379 amino acids, locates in Mitochondrion.

Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds, Substrate preference is 3-mercaptopyruvate > thiosulfate, Involved in embryo and seed development


This is Accelerated cell death 11 protein, from Mouse-ear cress, contains 206 amino acids, is soluble, locates in Cytoplasm.

Exhibits selective intermembrane transfer of ceramide-1-phosphate (C1P) and phytoceramide-1-phosphate (PubMed:24412362, PubMed:28011644), Does not transport ceramide (Cer) or GalCer, suggesting a requirement for phosphate in the headgroup for functionality (PubMed:24412362), Transports in vitro sphingosine, but not glycosphingolipids (PubMed:11850411), Has also some in vitro activity with sphingomyelin, a lipid not detected in plant tissues (PubMed:18657186), The transport function may be not directly involved in regulating cell death, Rather, perturbations in the function of ACD11 or related components could be monitored by R-proteins, which then mediate defense and programmed cell death (PCD), as proposed in the guard hypothesis (Probable), C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644), Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:28011644)


This is UTP:RNA uridylyltransferase 1 protein, from Mouse-ear cress, contains 764 amino acids, is soluble, locates in Cytoplasm.

UTP:RNA uridylyltransferase with a marked preference for uridine polymerization and a distributive activity for the first added nucleotides (PubMed:23748567, PubMed:25928405), Uridylates oligo(A)-tailed mRNAs to prevent 3' to 5' ribonucleotytic attacks (PubMed:23748567), Reduces the accumulation of oligo(A)-tailed mRNAs (PubMed:33637717), Prevents the accumulation of excessively deadenylated mRNAs to avoid siRNA biogenesis (PubMed:26972004, PubMed:33637717), Uridylation repairs deadenylated extremities to restore the size distribution observed for non-uridylated oligo(A) tails (PubMed:26972004), Can prevent the 3' trimming of mRNAs still engaged on polysomes (PubMed:23748567), Acts synergistically with HESO1 in unmethylated miRNA uridylation, leading to their degradation (PubMed:25928341), URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs (PubMed:25928405), URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1 (PubMed:25928405), URT1 and HESO1 are involved in the uridylation and clearance of RISC-generated 5' mRNA fragments (PubMed:30364210), Has no effect on uridylation of heterochromatic siRNAs (PubMed:25928341), Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1 (PubMed:25928405), Acts as post-transcriptional gene silencing (PTGS) suppressor (PubMed:31076735)

Belongs to the DNA polymerase type-B-like family


This is Protein kinase PINOID protein, from Mouse-ear cress, contains 438 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase involved in the regulation of auxin signaling, Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing polar auxin transport, Phosphorylates conserved serine residues in the PIN auxin efflux carriers, Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis, Acts in association with PIN1 to control the establishment of bilateral symmetry and promotion of cotyledon outgrowth, Regulates root gravitropism through modulation of PIN2-dependent basipetal auxin transport, Required for polarization of PIN3-dependent auxin transport for hypocotyl gravitropic response, The protein kinase activity of PID is essential for its auxin efflux regulatory function, PID kinase and PP2A phosphatase activities antagonistically regulate phosphorylation of PIN proteins, affecting PIN sorting

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is LysM domain receptor-like kinase 4 protein, from Mouse-ear cress, contains 612 amino acids, is membrane-bound, locates in Cell membrane.

Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity, Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands, Involved in the resistance to the pathogenic fungus Alternaria brassicicola and to the bacterial pathogen the bacterial pathogen Pseudomonas syringae pv tomato DC3000, probably by sensing microbe-associated molecular pattern (MAMP) and pathogen-associated molecular patterns (PAMP), May play a role in detecting peptidoglycans (e,g, PGNs) during bacterial growth


This is Beta-glucosidase 26, peroxisomal protein, from Mouse-ear cress, contains 560 amino acids, locates in Peroxisome.

Possesses beta-glucosidase activity toward 4-methyl-umbelliferyl-beta-D-glucoside in vitro, Possesses myrosinase activity toward indol-3-yl-methylglucosinolate (I3M) and 4-methoxy-indol-3-yl-methylglucosinolate (4MO-I3M) in vivo (PubMed:19095900), Component of an inducible preinvasion resistance mechanism that prevents penetration of the nonhost fungal species B,graminis and E,pisi (PubMed:16293760), Involved in indole glucosinolate (IGS) activation during pattern-triggered immunity (PTI), Functions as myrosinase for the breakdown of flg22-triggered IGS, Required for both callose deposition and glucosinolate activation during pathogen-triggered resistance (PubMed:19095898), During fungal attack, required for IGS activation that mediates broad-spectrum antifungal defense (PubMed:19095900)

Belongs to the glycosyl hydrolase 1 family


This is Nucleoside diphosphate kinase II, chloroplastic protein, from Mouse-ear cress, contains 231 amino acids, locates in Plastid.

Major role in the synthesis of nucleoside triphosphates other than ATP, The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate, May activate MPK3 and MPK6, May be involved in the regulation of cellular redox state and hydrogen peroxide-mediated MAP kinase signaling


This is Beta-amylase 2, chloroplastic protein, from Mouse-ear cress, contains 542 amino acids, locates in Plastid.

Low beta-amylase activity, Interacts poorly with starch or other alpha-1,4-glucan

Belongs to the glycosyl hydrolase 14 family


This is 20 kDa chaperonin, chloroplastic protein, from Mouse-ear cress, contains 253 amino acids, locates in Plastid.

Involved in abscisic acid (ABA) signaling, independently of its co-chaperone role, Acts as negative regulator of the CHLH-WRKY40 coupled ABA signaling pathway, downstream of CHLH and upstream of WRKY40


This is Subtilisin-like protease SBT1.7 protein, from Mouse-ear cress, contains 757 amino acids, is soluble, locates in Extracellular.

Serine protease, Has a substrate preference for the hydrophobic residues Phe and Ala and the basic residue Asp in the P1 position, and for Asp, Leu or Ala in the P1' position (PubMed:12413398), Essential for mucilage release from seed coats, Triggers the accumulation and/or activation of cell wall modifying enzymes necessary either for the loosening of the outer primary cell wall, or to facilitate swelling of the mucilage (PubMed:18266922)


This is Aspartic proteinase A1 protein, from Mouse-ear cress, contains 506 amino acids, locates in Lysosome/Vacuole.

Involved in the breakdown of propeptides of storage proteins in protein-storage vacuoles (By similarity), Possesses aspartic protease activity in vitro


This is CBL-interacting serine/threonine-protein kinase 6 protein, from Mouse-ear cress, contains 441 amino acids, locates in Endoplasmic reticulum.

CIPK serine-threonine protein kinases interact with CBL proteins, Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner, Downstream of CBL1, CBL2, CBL3 and CBL9, regulates by phosphorylation the K(+) conductance and uptake of AKT1, Binds to CBL4 to modulate AKT2 activity by promoting a kinase interaction-dependent but phosphorylation-independent translocation of the channel to the plasma membrane

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is Villin-4 protein, from Mouse-ear cress, contains 974 amino acids, is soluble, locates in Cytoplasm.

Binds actin and actin filament bundles in a Ca(2+)-insensitive manner, but caps the barbed end of actin filaments and is able to sever them in a calcium-dependent manner, Involved in root hair growth through regulating actin organization in a Ca(2+)-dependent manner


This is Carotenoid 9,10(9',10')-cleavage dioxygenase 1 protein, from Mouse-ear cress, contains 538 amino acids, is soluble, locates in Cytoplasm.

Cleaves a variety of carotenoids symmetrically at both the 9-10 and 9'-10' double bonds, Active on beta,beta-carotene, lutein, zeaxanthin, all-trans-violaxanthin, 9-cis-violaxanthin and 9'-cis-neoxanthin, With most substrates, the carotenoid is symmetrically cleaved, Probably not involved in abscisic acid biosynthesis

Belongs to the carotenoid oxygenase family


This is Putative nucleotidyltransferase MAB21L1 protein, from Mouse, contains 359 amino acids, locates in Nucleus.

Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning (PubMed:11857508, PubMed:12642482), It is unclear whether it displays nucleotidyltransferase activity in vivo (By similarity), Binds single-stranded RNA (ssRNA) (By similarity)


This is PDZ and LIM domain protein 1 protein, from Mouse, contains 327 amino acids, is soluble, locates in Cytoplasm.

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity), Involved in assembly, disassembly and directioning of stress fibers in fibroblasts, Required for the localization of ACTN1 and PALLD to stress fibers, Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity)


This is H(+)/Cl(-) exchange transporter 7 protein, from Mouse, contains 803 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:16525474, PubMed:19661288), Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:16525474, PubMed:19661288), The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity), The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)

Belongs to the chloride channel (TC 2,A,49) family, ClC-7/CLCN7 subfamily


This is Peroxisomal membrane protein 11A protein, from Rat, contains 246 amino acids, is membrane-bound, locates in Peroxisome.

May be involved in peroxisomal proliferation and may regulate peroxisomes division, May mediate binding of coatomer proteins to the peroxisomal membrane (PubMed:9548716), Promotes membrane protrusion and elongation on the peroxisomal surface


This is Vascular endothelial growth factor A-A protein, from Zebrafish, contains 188 amino acids, is soluble, locates in Extracellular.

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth, Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels, Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation

Belongs to the PDGF/VEGF growth factor family


This is Cell division control protein 45 homolog protein, from Fission yeast, contains 638 amino acids, locates in Nucleus.

Required for initiation of chromosomal DNA replication, May have a role in regulating the MCM proteins nda1 and nda4


This is Alpha-L-arabinofuranosidase B protein, from Aspergillus nidulans, contains 510 amino acids, is soluble, locates in Extracellular.

Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose, Able to hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan

Belongs to the glycosyl hydrolase 54 family


This is Vacuolar amino acid transporter 5 protein, from Fission yeast, contains 420 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine, Required for sporulation

Belongs to the amino acid/polyamine transporter 2 family


This is Cell division control protein 31 protein, from Fission yeast, contains 176 amino acids, locates in Nucleus.

Required for the proper coordination between exit from mitosis and the initiation of septation, Has a role in bipolar spindle formation during spindle pole body (SPB) duplication, Required for the localization of sad1 to the SPB (PubMed:12857865)


This is Extragenic suppressor of kinetochore protein 1 protein, from Fission yeast, contains 838 amino acids, locates in Nucleus.

Has a role in chromosome segregation, May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin


This is Maintenance of ploidy protein mob2 protein, from Fission yeast, contains 244 amino acids, is soluble, locates in Cytoplasm.

Required for coordinating polarized cell growth during interphase with the onset of mitosis


This is Mitochondrial import inner membrane translocase subunit TIM9 protein, from Baker's yeast, contains 87 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane, Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space, Compared to TIM10, it may have a strong structural role


This is Elongation factor 1 alpha-like protein protein, from Fission yeast, contains 592 amino acids, is soluble, locates in Cytoplasm.

GTPase component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290), The Dom34-Hbs1 complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (By similarity), Following ribosome-binding, the Pelota-HBS1L complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity)

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family


This is GTPase grn1 protein, from Fission yeast, contains 470 amino acids, locates in Nucleus.

Required for optimal growth, Required for normal processing of ribosomal pre-rRNA, Required for nuclear export of ribosomal protein rpl2501

Belongs to the TRAFAC class YlqF/YawG GTPase family


This is UV excision repair protein rhp23 protein, from Fission yeast, contains 368 amino acids, locates in Nucleus.

Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation


This is mRNA cap guanine-N7 methyltransferase protein, from Fission yeast, contains 360 amino acids, locates in Nucleus.

Responsible for methylating the 5'-cap structure of mRNAs

Belongs to the class I-like SAM-binding methyltransferase superfamily, mRNA cap 0 methyltransferase family


This is RNA-binding protein rnc1 protein, from Fission yeast, contains 398 amino acids, is soluble, locates in Cytoplasm.

Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling, Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion


This is RNA binding exosome specificity factor Mmi1 protein, from Fission yeast, contains 488 amino acids, locates in Nucleus.

RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity), Functions alone and as part of the erh1-mmi1 complex, to recruit the CCR4-NOT complex and the NURS complex to target RNAs (PubMed:26942678, PubMed:30651569, PubMed:31974447), Suppresses the meiotic program during vegetative growth and promotes the meiotic program during mating (PubMed:31974447), Binds to DSR (determinant of selective removal) regions in meiotic mRNA, and recruits the NURS complex to targets (PubMed:16823445, PubMed:26942678), Recruitment of NURS complex to target mRNAs promotes mRNA decay by engagement of the nuclear exosome, and formation of heterochromatin islands at meiotic genes silenced by the exosome (PubMed:16823445, PubMed:26942678), Recruitment of the CCR4-NOT complex to target RNAs promotes heterochromatin formation at RNAi-dependent heterochromatin domains (HOODs), including a subset of meiotic genes, lncRNAs and retrotransposons (PubMed:26942678), Recruitment of the CCR4-NOT complex to rDNA promotes rDNA heterochromatin assembly (PubMed:26942678), Promotes non-canonical transcription termination at meiotic genes and prevents lncRNA transcription from invading and repressing adjacent genes (PubMed:16823445, PubMed:30651569)


This is DNA endonuclease ctp1 protein, from Fission yeast, contains 294 amino acids, locates in Nucleus.

Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends, Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection, Required for the repair of programmed meiotic DSBs, Involved also in an rhp51 recombinase-dependent recombinational repair pathway


This is Serine/threonine-protein kinase nak1 protein, from Fission yeast, contains 652 amino acids, is soluble, locates in Cytoplasm.

Has a role in the regulation of cell polarity, growth and division


This is Glycosaminoglycan xylosylkinase protein, from Human, contains 409 amino acids, is membrane-bound, locates in Golgi apparatus.

Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains, Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases, Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized


This is Pentatricopeptide repeat-containing protein 1, mitochondrial protein, from Human, contains 700 amino acids, is soluble, locates in Mitochondrion.

Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encoded proteins and COX activity, Affects also the 3'-processing of mitochondrial tRNAs


This is Peroxisomal membrane protein 11A protein, from Human, contains 247 amino acids, is membrane-bound, locates in Peroxisome.

May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670), May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity), Promotes membrane protrusion and elongation on the peroxisomal surface (PubMed:20826455)


This is RNA/RNP complex-1-interacting phosphatase protein, from Human, contains 377 amino acids, locates in Nucleus.

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity, In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro), Binds to RNA, May participate in nuclear mRNA metabolism

Belongs to the protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily


This is Semaphorin-7A protein, from Human, contains 666 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses, Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3, Promotes production of pro-inflammatory cytokines by monocytes and macrophages, Plays an important role in modulating inflammation and T-cell-mediated immune responses, Promotes axon growth in the embryonic olfactory bulb, Promotes attachment, spreading and dendrite outgrowth in melanocytes


This is Peroxisomal membrane protein PEX14 protein, from Human, contains 377 amino acids, is membrane-bound, locates in Peroxisome.

Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:9653144, PubMed:24235149, PubMed:28765278), The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity), Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:24235149, PubMed:28765278), Plays a key role for peroxisome movement through a direct interaction with tubulin (PubMed:21525035)


This is Pre-mRNA-processing factor 40 homolog A protein, from Human, contains 957 amino acids, is soluble, locates in Nucleus.

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity), Plays a role in the regulation of cell morphology and cytoskeletal organization, Required in the control of cell shape and migration, May play a role in cytokinesis, May be involved in pre-mRNA splicing


This is Metaxin-2 protein, from Human, contains 263 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in transport of proteins into the mitochondrion


This is Serine/threonine-protein kinase/endoribonuclease IRE1 protein, from Human, contains 977 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11175748, PubMed:11779464, PubMed:12637535, PubMed:21317875, PubMed:28128204, PubMed:9637683, PubMed:30118681), In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875), Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875), The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875), The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875), Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262)


This is Nuclear receptor subfamily 1 group I member 2 protein, from Human, contains 434 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds, Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds, Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones, Response to specific ligands is species-specific, Activated by naturally occurring steroids, such as pregnenolone and progesterone, Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Erlin-1 protein, from Human, contains 348 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

(Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production


This is Transcription initiation protein SPT3 homolog protein, from Human, contains 317 amino acids, locates in Nucleus.


This is Ceroid-lipofuscinosis neuronal protein 5 protein, from Human, contains 358 amino acids, locates in Lysosome/Vacuole.

Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane, Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521)


This is Tumor necrosis factor receptor superfamily member 21 protein, from Human, contains 655 amino acids, is membrane-bound, locates in Cell membrane.

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B, Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm, Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning, Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP), N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6), Negatively regulates oligodendrocyte survival, maturation and myelination, Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation, Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells, Negatively regulates the production of IgG, IgM and IgM in response to antigens, May inhibit the activation of JNK in response to T-cell stimulation


This is KH domain-containing, RNA-binding, signal transduction-associated protein 3 protein, from Human, contains 346 amino acids, locates in Nucleus.

(Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression


This is Transcriptional adapter 3 protein, from Human, contains 432 amino acids, locates in Nucleus.

Functions as a component of the PCAF complex, The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context, The PCAF complex could be considered as the human version of the yeast SAGA complex, Also known as a coactivator for p53/TP53-dependent transcriptional activation, Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4


This is TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L protein, from Human, contains 589 amino acids, locates in Nucleus.

Functions as a component of the PCAF complex, The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context, The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable), With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming, Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity)


This is Src kinase-associated phosphoprotein 2 protein, from Human, contains 359 amino acids, is soluble, locates in Cytoplasm.

May be involved in B-cell and macrophage adhesion processes, In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation, May play a role in src signaling pathway


This is Protein CREG1 protein, from Human, contains 220 amino acids, is soluble, locates in Extracellular.

May contribute to the transcriptional control of cell growth and differentiation, Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein, The transcriptional control activity of cell growth requires interaction with IGF2R


This is Mitochondrial tRNA-specific 2-thiouridylase 1 protein, from Human, contains 421 amino acids, locates in Mitochondrion.

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln), Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position, ATP is required to activate the C2 atom of the wobble base


This is TIP41-like protein protein, from Human, contains 272 amino acids, is soluble, locates in Cytoplasm.

May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A), Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro, The PP2A(C):TIPRL complex does not show phosphatase activity, Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX), May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair


This is Ribosomal protein S6 kinase alpha-4 protein, from Human, contains 772 amino acids, locates in Nucleus.

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes, Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin, Plays an essential role in the control of RELA transcriptional activity in response to TNF, Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN, May also phosphorylate 'Ser-28' of histone H3, Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14), In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines, Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily


This is Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial protein, from Human, contains 678 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575), Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton, Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Carbonyl reductase [NADPH] 3 protein, from Human, contains 277 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841), Has low NADPH-dependent oxidoreductase activity, Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:18493841, PubMed:15537833, PubMed:19841672), Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672), Exerts activity toward ortho-quinones but not paraquinones, No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Protein SCO1 homolog, mitochondrial protein, from Human, contains 301 amino acids, locates in Mitochondrion.

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2), Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation, Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189), Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity)


This is Tumor necrosis factor ligand superfamily member 13 protein, from Human, contains 250 amino acids, is soluble, locates in Extracellular.

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA, Plays a role in the regulation of tumor cell growth, May be involved in monocyte/macrophage-mediated immunological processes

Belongs to the tumor necrosis factor family


This is E3 SUMO-protein ligase PIAS1 protein, from Human, contains 651 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

(Microbial infection) Restricts Epstein-Barr virus (EBV) lytic replication by acting as an inhibitor for transcription factors involved in lytic gene expression (PubMed:29262325), The virus can use apoptotic caspases to antagonize PIAS1-mediated restriction and express its lytic genes (PubMed:29262325)


This is E3 SUMO-protein ligase PIAS2 protein, from Human, contains 621 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied, However, it seems to be mostly involved in gene silencing, Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity, Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation, Isoform PIAS2-alpha promotes PARK7 sumoylation, Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha, Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'


This is Cell cycle checkpoint protein RAD17 protein, from Human, contains 681 amino acids, locates in Nucleus.

Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage, Has a weak ATPase activity required for binding to chromatin, Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation, May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination


This is Glutaredoxin-3 protein, from Human, contains 335 amino acids, is soluble, locates in Cytoplasm.

Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415), Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity), Required for hemoglobin maturation (PubMed:23615448), Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity


This is Ribosomal L1 domain-containing protein 1 protein, from Human, contains 490 amino acids, locates in Nucleus.

Regulates cellular senescence through inhibition of PTEN translation, Acts as a pro-apoptotic regulator in response to DNA damage

Belongs to the universal ribosomal protein uL1 family, Highly divergent


This is Cyclin-dependent kinase-like 5 protein, from Human, contains 960 amino acids, locates in Nucleus.

Mediates phosphorylation of MECP2 (PubMed:15917271, PubMed:16935860), May regulate ciliogenesis (PubMed:29420175)

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily


This is Delta(14)-sterol reductase TM7SF2 protein, from Human, contains 418 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis


This is Cell death protein 6 protein, from Caenorhabditis elegans, contains 492 amino acids, is soluble, locates in Cytoplasm.

May function as an adapter protein in a pathway that mediates recognition and phagocytosis of apoptotic cells during normal development, Promotes engulfment of cells at both early and late stages of apoptosis, Required for actin reorganization around apoptotic cells, Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration (PubMed:29346382), Mediates recruitment of E3 ubiquitin-protein ligase trim-21 to the apoptotic cell surface which promotes ubiquitination and degradation of ced-1 (PubMed:35929733)


This is DNA repair and recombination protein RAD54-like protein, from Fruit fly, contains 784 amino acids, locates in Nucleus.

Involved in mitotic DNA repair and meiotic recombination, Functions in the recombinational DNA repair pathway, Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51, In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54

Belongs to the SNF2/RAD54 helicase family


This is Sodium-dependent acetylcholine transporter protein, from Caenorhabditis elegans, contains 714 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites, Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine), Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-glycoprotein complex (DGC) function results in muscle degeneration

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family


This is PBAN-type neuropeptides protein, from Black cutworm moth, contains 193 amino acids, is soluble, locates in Extracellular.

A hormone that controls sex pheromone production in female moths and pheromone responsiveness in male (PubMed:9753769)


This is Protein cramped protein, from Fruit fly, contains 982 amino acids, locates in Nucleus.

Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination, Can act as a modifier of position effect variegation (PEV)


This is Protein aubergine protein, from Fruit fly, contains 866 amino acids, is soluble, locates in Cytoplasm.

Acts via the piwi-interacting RNA (piRNA) metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements, In ovary, associates predominantly with antisense piRNAs that contain uridine at their 5' end, In testis, associates with Su(Ste) antisense piRNAs (most abundant class of piRNAs found in complex with aub in testes) and negatively regulates Ste expression, most likely by cleaving its transcripts, Also in testis, may repress translation of vas when associated with a piRNA derived from chromosome X, termed AT-chX-1, whose sequence shows strong complementarity to vas mRNA, Aub-piRNA complexes from ovary and testis possess RNA cleavage activity, Involved in telomere regulation by repressing specialized telomeric retroelements HeT-A and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements, Also involved in telomeric trans-silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans, in the female germline, a homologous transposon, or transgene located in euchromatin, Involved in the suppression of meiotic drive of sex chromosomes and autosomes, Involved in transposon silencing in the adult brain, Required for dorsal-ventral as well as anterior-posterior patterning of the egg, Required during oogenesis for primordial germ cell formation and activation of RNA interference, During early oogenesis, required for osk mRNA silencing and polarization of the microtubule cytoskeleton, During mid-oogenesis, required for osk mRNA localization to the posterior pole and efficient translation of osk and grk, During embryogenesis, required for posterior localization of nos mRNA, independently of osk, and pole cell formation, Essential for the formation and/or structural integrity of perinuclear nuage particles, Required for the localization of Mael to the meiotic nuage, Forms a complex with smg, twin, AGO3 and specific piRNAs that targets nos mRNA (and probably other maternal mRNAS) for deadenylation promoting its decay during early embryogenesis

Belongs to the argonaute family, Piwi subfamily


This is Fibulin-1 protein, from Caenorhabditis elegans, contains 728 amino acids, is soluble, locates in Extracellular.

Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall-muscle basement membranes


This is Decapping and exoribonuclease protein protein, from Human, contains 396 amino acids, locates in Nucleus.

Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (PubMed:28283058), The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (PubMed:28283058), In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:28283058), Preferentially acts on NAD-capped transcripts in response to environmental stress (PubMed:31101919), Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity), Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity), Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (PubMed:29601584), In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (By similarity), Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs (PubMed:29601584), Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity), Exhibits decapping activity towards FAD-capped RNAs (PubMed:32374864), Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)


This is Superoxide dismutase [Cu-Zn] 2, chloroplastic protein, from Mouse-ear cress, contains 216 amino acids, locates in Plastid.

Destroys radicals which are normally produced within the cells and which are toxic to biological systems, Mediates tolerance to stress, including photo-oxidative stress

Belongs to the Cu-Zn superoxide dismutase family


This is N-alpha-acetyltransferase MAK3 protein, from Mouse-ear cress, contains 190 amino acids, is soluble, locates in Cytoplasm.

Probably required for N-acetylation of some chloroplast precursor proteins and efficient accumulation of thylakoid multiprotein complexes, In yeast, can replace the NatC complex (composed of MAK3, MAK10 and MAK31) by acetylating N termini of endogenous proteins and the N-terminus Met of L-A virus Gag protein, However, the formation of a NatC complex is not required for this function

Belongs to the acetyltransferase family, MAK3 subfamily


This is Pyridoxal 5'-phosphate synthase subunit PDX1.1 protein, from Mouse-ear cress, contains 309 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia, The ammonia is provided by PDX2, Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively, Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers


This is AMP deaminase protein, from Mouse-ear cress, contains 839 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

AMP deaminase plays a critical role in energy metabolism, Essential for the transition from zygote to embryo

Belongs to the metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family


This is Dehydrodolichyl diphosphate synthase 1 protein, from Mouse-ear cress, contains 303 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier-lipid required for the biosynthesis of several classes of glycoprotein


This is Extra-large guanine nucleotide-binding protein 1 protein, from Mouse-ear cress, contains 888 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity), Binds GTP with specificity, Plays a role in the root morphogenesis by regulation of the cell proliferation

Belongs to the G-alpha family, XLG subfamily


This is Outer envelope pore protein 37, chloroplastic protein, from Mouse-ear cress, contains 343 amino acids, is membrane-bound, locates in Plastid.

Voltage-dependent peptide-sensitive high conductance rectifying cation channel with a strong affinity for TIC32 that is imported into the chloroplast, Conductance is pH-dependent decreasing with decreasing pH values

Belongs to the plastid outer envelope porin OEP37 (TC 1,B,47) family


This is Protein ENDOSPERM DEFECTIVE 1 protein, from Mouse-ear cress, contains 474 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated protein required for seed development and for microtubule function in the endosperm, Associates with nuclear microtubules during mitosis, Binds to microtubules of the spindle and spindle-poles and to midzone microtubules out of which the phragmoplast emerges, Not associated with cortical microtubules, Required for endosperm cellularization, May be bound and sequestered by GRF5 in an inactive soluble form during the early stages of mitosis


This is SNW/SKI-interacting protein protein, from Mouse-ear cress, contains 613 amino acids, locates in Nucleus.

Splicing factor involved in post-transcriptional regulation of circadian clock and flowering time genes, Associates with the pre-mRNA of PRR7, PRR9, ELF3 and GI, and is necessary for the regulation of their alternative splicing and mRNA maturation, Probably involved in splice site recognition


This is Receptor-like protein CLAVATA2 protein, from Mouse-ear cress, contains 720 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance, Required for the sensing of the root CLE peptides (e,g, CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45), which involves also CRN and leads to root growth regulation, mostly in the phloem and protophloem (PubMed:28607033), Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development, Promotes the formation of CLV1 multimers, In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway (PubMed:21265896, PubMed:21750229), This recognition is required for proper feeding structure (syncytium) development and ultimately successful nematode infection (PubMed:21265896, PubMed:21750229), CLE14 perception by CLV2/CRN complex triggers root meristem differentiation (PubMed:20697738, PubMed:28586647)


This is Peroxisomal membrane protein 11D protein, from Mouse-ear cress, contains 236 amino acids, is membrane-bound, locates in Peroxisome.

Involved in peroxisomal proliferation, Promotes peroxisomal duplication, aggregation or elongation without fission


This is ATP-dependent zinc metalloprotease FTSH 2, chloroplastic protein, from Mouse-ear cress, contains 695 amino acids, is membrane-bound, locates in Plastid.

Part of a complex that function as an ATP-dependent zinc metallopeptidase, Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions, but not involved in thermotolerance

In the C-terminal section; belongs to the peptidase M41 family


This is ATP-dependent zinc metalloprotease FTSH 4, mitochondrial protein, from Mouse-ear cress, contains 717 amino acids, is membrane-bound, locates in Mitochondrion.

Probable ATP-dependent zinc metallopeptidase, Involved in the assembly and/or stability of the complex V of the mitochondrial oxidative phosphorylation system


This is Signal peptide peptidase protein, from Mouse-ear cress, contains 344 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane (By similarity), Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm (By similarity), Plays a critical role in the development and function of the reproductive tissues, especially in pollen development


This is Serine/arginine-rich splicing factor RSZ21 protein, from Mouse-ear cress, contains 187 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

Probably involved in intron recognition and spliceosome assembly

Belongs to the splicing factor SR family, RSZ subfamily


This is Light-harvesting complex-like protein OHP1, chloroplastic protein, from Mouse-ear cress, contains 110 amino acids, is membrane-bound, locates in Plastid.

May play a photoprotective role in the thylakoid membrane in response to light stress (Probable), Involved in photosystems I (PSI) and II (PSII) core proteins function (PubMed:29438089), Forms a trimeric complex with OHP2 and HCF244 that is required to promote PSII core subunit assembly (PubMed:29930106, PubMed:30397023), The trimeric complex forms a transient PSII reaction center-like complex with PsbA, PsbD, PsbE, PsbF and PsbI subunits in thylakoids for early assembly of PSII as well as PSII repair (PubMed:30397023), The trimeric complex is required for the recruitment of ribosomes to the psbA mRNA during PSII biogenesis and repair (PubMed:31991763), Forms an heterodimer with OHP1 that binds chlorophylls and carotenoids, and that may function in the delivery of pigments to the PsbA subunit of PSII (PubMed:32071152)


This is Superoxide dismutase [Mn] 1, mitochondrial protein, from Mouse-ear cress, contains 231 amino acids, is soluble, locates in Mitochondrion.

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems

Belongs to the iron/manganese superoxide dismutase family


This is Calcineurin B-like protein 1 protein, from Mouse-ear cress, contains 213 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a calcium sensor involved in the signaling pathway during growth and development and in response to abiotic stresses, May function as a positive regulator of salt and drought responses and as a negative regulator of cold response, Contributes to the regulation of early stress-related CBF/DREB transcription factors, CBL proteins interact with CIPK serine-threonine protein kinases, Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner, Mediates the activation of AKT1 by CIPK proteins (CIPK6, CIPK16, and CIPK23) in response to low potassium conditions and in the context of stomatal movement, Involved in response to glucose and gibberellin during germination and seedling development and in response to cold stress, Involved in the calcium-dependent regulation by CIPK26 of reactive oxygen species production by the NADPH oxidase RBOHF

Belongs to the calcineurin regulatory subunit family


This is Protein GLUTAMINE DUMPER 1 protein, from Mouse-ear cress, contains 158 amino acids, is membrane-bound, locates in Cell membrane.

Probable subunit of an amino acid transporter involved in the regulation of the amino acid metabolism, Stimulates amino acid export by activating nonselective amino acid facilitators, Required the interaction with the RING-type E3 ubiquitin-protein ligase LOG2 to fulfill its function, Plays a role in the Gln export at hydathodes, at xylem parenchyma into xylem sap and from mesophyll into leaf apoplasm, Acts upstream genes involved in the salicylic acid (SA) pathway and in the geminivirus-host interaction

Belongs to the GLUTAMINE DUMPER 1 (TC 9,B,60) family


This is Protein SPOROCYTELESS protein, from Mouse-ear cress, contains 314 amino acids, locates in Nucleus.

Transcriptional regulator of sporocyte development (PubMed:10465788), Acts as an adapter-like transcriptional repressor recruiting TPL/TPR corepressors to inhibit TCP transcription factors (PubMed:25378179), Required for nucellus and embryo sac development (PubMed:10500234), Plays a central role in patterning both the proximal-distal and the adaxial-abaxial axes during ovule development (PubMed:12183381), Involved in establishing the prospective chalaza of the ovule and in controlling the cell number and the length of the funiculus, and is required for the development of the integuments (PubMed:10976054), Required, with BEL1, for cytokinin-induced PIN1 expression in ovules (PubMed:22786869), Involved in controlling stamen identity (PubMed:19726570), May also regulate the morphology of lateral organs by repressing auxin production (PubMed:18557819)


This is E3 ubiquitin-protein ligase BOI protein, from Mouse-ear cress, contains 304 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase involved in the regulation of pathogen and abiotic stress responses by facilitating degradation of MYB108/BOI, Attenuates cell death by preventing caspase activation, Has no effect on the stability of the DELLA proteins, Not regulated by MYB108/BOI


This is Receptor-like serine/threonine-protein kinase SD1-8 protein, from Mouse-ear cress, contains 850 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the regulation of cellular expansion and differentiation

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Dehydration-responsive element-binding protein 2A protein, from Mouse-ear cress, contains 335 amino acids, locates in Nucleus.

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3' (PubMed:11798174), Binding to the C-repeat/DRE element mediates high salinity- and dehydration-inducible transcription (PubMed:11798174), Promotes the expression of heat stress-inducible genes by contributing to the formation of a heat stress-specific transcriptional complex with NF-Y subunits (e,g, DPB3-1, NF-YA2 and NF-YB3) at the promoter of target genes, thus promoting heat tolerance (PubMed:25490919)

Belongs to the AP2/ERF transcription factor family, ERF subfamily


This is AT-hook motif nuclear-localized protein 21 protein, from Mouse-ear cress, contains 285 amino acids, is soluble, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs), Binds to the MARs present in the ETTIN (ETT) promoter leading to a negative regulation of its gene expression, Functions as a molecular node downstream of the homeotic protein AGAMOUS (AG), regulating patterning and differentiation of reproductive organs, Acts as a chromatin remodeling factor that modifies the architecture of ETTIN (ETT) chromatin by modulating H3 methylation leading to the regulation of ETT expression, Seems to be involved in the regulation of a set of reproductives genes including CRABS CLAW (CRC), JAGGED (JAG) and KNUCKLES (KNU)


This is ADP-ribosylation factor GTPase-activating protein AGD10 protein, from Mouse-ear cress, contains 395 amino acids, has 1 C4-type Zinc finger, locates in Golgi apparatus.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF), Activates ARF1 and ARF2, Required for female gametophyte development, Involved in root hair and pollen tube growth


This is Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase protein, from Mouse-ear cress, contains 438 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for N-linked oligosaccharide assembly, Adds the sixth mannose residue in an alpha-1,3 linkage onto the dolichol-PP-oligosaccharide precursor dolichol-PP-Man(5)GlcNAc(2)

Belongs to the glycosyltransferase 58 family


This is Protein SLOW WALKER 1 protein, from Mouse-ear cress, contains 530 amino acids, locates in Nucleus.

Essential protein required for nuclear division and organization during embryo sac development in female gametophyte, probably by promoting rRNA biogenesis essential for the progression of the mitotic division cycles during gametogenesis (PubMed:15634699, PubMed:15980260), Involved in nucleolar processing of pre-18S ribosomal RNA (PubMed:15980260)


This is Transcription factor TCP10 protein, from Mouse-ear cress, contains 361 amino acids, locates in Nucleus.

Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e,g, miR164), Participates in ovule develpment (PubMed:25378179)


This is Probable inactive poly [ADP-ribose] polymerase SRO1 protein, from Mouse-ear cress, contains 568 amino acids, is soluble, locates in Nucleus.

Probable inactive ADP-ribosyltransferase that functions with RCD1 to regulate oxidative stress, hormonal and developmental responses, May regulate some stress-responsive genes, Seems to play a smaller developmental role than R


This is Sodium-dependent phosphate transport protein 1, chloroplastic protein, from Mouse-ear cress, contains 512 amino acids, is membrane-bound, locates in Plastid.

Specific for inorganic phosphate transport across the thylakoid membrane in a sodium dependent manner, Binds glutamate but cannot transport it, May act as an ascorbate transporter at the thylakoid membrane (Probable)

Belongs to the major facilitator superfamily, Sodium/anion cotransporter (TC 2,A,1,14) family


This is Phosphomethylpyrimidine synthase, chloroplastic protein, from Mouse-ear cress, contains 644 amino acids, is soluble, locates in Plastid.

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction


This is N6-adenosine-methyltransferase MT-A70-like protein, from Mouse-ear cress, contains 685 amino acids, locates in Nucleus.

Catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:18505803, PubMed:28503769), Associates with MTB, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769), N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:18505803, PubMed:28503769)


This is Bidirectional sugar transporter SWEET12 protein, from Mouse-ear cress, contains 285 amino acids, is membrane-bound, locates in Cell membrane.

Mediates both low-affinity uptake and efflux of sugar across the plasma membrane, Involved in phloem loading by mediating export from parenchyma cells feeding H(+)-coupled import into the sieve element/companion cell complex, thus contributing to the sucrose migration from sites of synthesis in the mesophyll to the phloem (PubMed:22157085, PubMed:25988582), Contributes to seed filling by triggering sucrose efflux involved in the transfer of sugars from seed coat to embryos (PubMed:25988582)

Belongs to the SWEET sugar transporter family


This is Photosystem II stability/assembly factor HCF136, chloroplastic protein, from Mouse-ear cress, contains 403 amino acids, is membrane-bound, locates in Plastid.

Essential for photosystem II (PSII) biogenesis; required for assembly of an early intermediate in PSII assembly that includes D2 (psbD) and cytochrome b559, Has been suggested (PubMed:11826309) to be required for chlorophyll a binding


This is Succinate dehydrogenase [ubiquinone] flavoprotein subunit 1, mitochondrial protein, from Mouse-ear cress, contains 634 amino acids, is membrane-bound, locates in Mitochondrion.

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Belongs to the FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily


This is Magnesium dechelatase SGR1, chloroplastic protein, from Mouse-ear cress, contains 268 amino acids, is membrane-bound, locates in Plastid.

Magnesium chelatase involved in chlorophyll a degradation in the chlorophyll-protein complexes of photosystem I (PSI) and photosystem II (PSII) (PubMed:27604697), Contributes to the degradation of PSI and PSII in the thylakoid membranes (PubMed:27604697), Required to trigger chlorophyll degradation during natural and dark-induced leaf senescence (Probable) (PubMed:17468209), Mediates chlorophyll degradation during embryo degreening (PubMed:24043799, PubMed:28873256), Recombinant SGR1 possesses high dechelating activity against chlorophyll a, very low activity against chlorophyllide a, and no activity against chlorophyll b (PubMed:27604697), Magnesium dechelation of chlorophyll a by SGR1 activates chlorophyll b degradation by inducing the expression of NYC1, an enzyme involved in chlorophyll b degradation (PubMed:29425814)


This is Phosphoserine phosphatase, chloroplastic protein, from Mouse-ear cress, contains 295 amino acids, locates in Plastid.

Catalyzes the last step in the plastidial phosphorylated pathway of serine biosynthesis (PPSB), The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates, Required for embryo, pollen and root development, May be required preferentially for serine biosynthesis in non-photosynthetic tissues

Belongs to the HAD-like hydrolase superfamily, SerB family


This is High-affinity nitrate transporter 2.1 protein, from Mouse-ear cress, contains 530 amino acids, is membrane-bound, locates in Cell membrane.

Involved in nitrate transport, but does not seem to be able to mediate transport by its own, Acts as a dual component transporter with NTR3,1, Acts as a repressor of lateral root initiation under high sucrose/low nitrate conditions

Belongs to the major facilitator superfamily, Nitrate/nitrite porter (TC 2,A,1,8) family


This is Protein lifeguard 2 protein, from Rat, contains 316 amino acids, is membrane-bound, locates in Cell membrane.

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation, Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity)

Belongs to the BI1 family, LFG subfamily


This is Potassium channel subfamily K member 4 protein, from Mouse, contains 398 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-insensitive potassium channel (PubMed:9628867), Channel opening is triggered by mechanical forces that deform the membrane, Channel opening is triggered by raising the intracellular pH to basic levels (By similarity), The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity), Plays a role in the sensory perception of pain caused by pressure (PubMed:19279663), Plays a role in the perception of pain caused by heat (PubMed:19279663)

Belongs to the two pore domain potassium channel (TC 1,A,1,8) family


This is Forkhead box protein L2 protein, from Mouse, contains 375 amino acids, locates in Nucleus.

Transcriptional regulator, Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination, Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9, Has apoptotic activity in ovarian cells, Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen, Activates SIRT1 transcription under cellular stress conditions, Activates transcription of OSR2, Is a regulator of CYP19 expression, Is a transcriptional repressor of STAR, Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element


This is DNA (cytosine-5)-methyltransferase 3B protein, from Mouse, contains 859 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger, locates in Nucleus.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development, DNA methylation is coordinated with methylation of histones, May preferentially methylates nucleosomal DNA within the nucleosome core region, May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation, Seems to be involved in gene silencing, In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9, Functions as a transcriptional corepressor by associating with ZHX1 (By similarity), Required for DUX4 silencing in somatic cells (By similarity)

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is Menin protein, from Mouse, contains 611 amino acids, locates in Nucleus.

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4), Functions as a transcriptional regulator, Binds to the TERT promoter and represses telomerase expression, Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity, Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA, Positively regulates HOXC8 and HOXC6 gene expression (By similarity), May be involved in normal hematopoiesis through the activation of HOXA9 expression, May be involved in DNA repair


This is Long-chain fatty acid transport protein 3 protein, from Mouse, contains 667 amino acids, is membrane-bound, locates in Mitochondrion.

Mainly functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:15469937, PubMed:15699031), Can mediate the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across membranes (PubMed:15699031)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Sodium- and chloride-dependent transporter XTRP3B protein, from Mouse, contains 635 amino acids, is membrane-bound, locates in Cell membrane.

Does not show transporter activity with a range of tested amino acids including proline, glutamine, glutamic acid, leucine, alanine, histidine, glycine and arginine

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A20 subfamily


This is Golgi SNAP receptor complex member 1 protein, from Mouse, contains 250 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport, It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor, May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14), Participates in docking and fusion stage of ER to cis-Golgi transport, Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity)


This is Bromodomain-containing protein 7 protein, from Mouse, contains 651 amino acids, locates in Nucleus.

Acts both as coactivator and as corepressor, May play a role in chromatin remodeling, Transcriptional corepressor that down-regulates the expression of target genes, Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac), Binds to the ESR1 promoter, Recruits BRCA1 and POU2F1 to the ESR1 promoter, Coactivator for TP53-mediated activation of transcription of a set of target genes, Required for TP53-mediated cell-cycle arrest in response to oncogene activation, Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters, Inhibits cell cycle progression from G1 to S phase (By similarity), Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity, Induces dephosphorylation of GSK3B at 'Tyr-216', Down-regulates TRIM24-mediated activation of transcriptional activation by AR


This is GTP-binding protein RAD protein, from Mouse, contains 308 amino acids, is membrane-bound, locates in Cell membrane.

May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916), May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-dependent L-type Ca(2+) currents (PubMed:17525370), Regulates voltage-gated L-type calcium channel subunit alpha-1C trafficking to the cell membrane (PubMed:17525370), Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (PubMed:18056528), Inhibits phosphorylation and activation of CAMK2D (By similarity)

Belongs to the small GTPase superfamily, RGK family


This is Protocadherin alpha-4 protein, from Mouse, contains 947 amino acids, is membrane-bound, locates in Cell membrane.

Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable), Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523)


This is ATP-dependent Clp protease proteolytic subunit, mitochondrial protein, from Mouse, contains 272 amino acids, is soluble, locates in Mitochondrion.

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process, Has low peptidase activity in the absence of CLPX, The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates, Cleaves PINK1 in the mitochondrion


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 protein, from Mouse, contains 910 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions, Contributes to the native pacemaker currents in heart (If) and in neurons (Ih), May mediate responses to sour stimuli

Belongs to the potassium channel HCN family


This is Killer cell lectin-like receptor subfamily G member 1 protein, from Mouse, contains 188 amino acids, is membrane-bound, locates in Cell membrane.

Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands, May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells


This is Calcium-binding protein 1 protein, from Rat, contains 298 amino acids, is soluble, locates in Cytoplasm.

Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs), Inhibits agonist-induced intracellular calcium signaling (By similarity), Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310), Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function, Suppresses the calcium-dependent inactivation of CACNA1D, Inhibits TRPC5 channels, Prevents NMDA receptor-induced cellular degeneration, Required for the normal transfer of light signals through the retina (By similarity)


This is Kynurenine 3-monooxygenase protein, from Rat, contains 478 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn), Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development, Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract

Belongs to the aromatic-ring hydroxylase family, KMO subfamily


This is Tumor protein 63 protein, from Mouse, contains 680 amino acids, locates in Nucleus.

Acts as a sequence specific DNA binding transcriptional activator or repressor, The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity, May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes, Involved in Notch signaling by probably inducing JAG1 and JAG2, Activates transcription of the p21 promoter (By similarity), Activates RIPK4 transcription, Plays a role in the regulation of epithelial morphogenesis, The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm, Required for limb formation from the apical ectodermal ridge


This is E3 SUMO-protein ligase PIAS1 protein, from Mouse, contains 651 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, In vitro, binds A/T-rich DNA (By similarity), The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context, Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation, PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation, Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation, Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474)


This is Zinc finger and BTB domain-containing protein 7A protein, from Mouse, contains 569 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, locates in Nucleus.

C2H2-type 4; atypical

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:15337766, PubMed:15662416, PubMed:17495164, PubMed:26816381, PubMed:29813070), Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:15337766, PubMed:15662416, PubMed:26816381, PubMed:29813070), Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (By similarity), That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity), Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (PubMed:29813070), Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (By similarity), Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (By similarity), Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity), Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381), Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381), Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (PubMed:15662416), Efficiently abrogates E2F1-dependent CDKN2A transactivation (PubMed:15662416), Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (PubMed:15337766), Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (By similarity), Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity), Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (PubMed:17495164), Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (PubMed:17495164), Also regulates osteoclast differentiation (By similarity), May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (PubMed:26446488), Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (PubMed:26446488), May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity)


This is Krueppel-like factor 10 protein, from Mouse, contains 479 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3', May play a role in the cell cycle regulation (By similarity), Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity, Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver, Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Bis(5'-adenosyl)-triphosphatase protein, from Mouse, contains 150 amino acids, is soluble, locates in Cytoplasm.

Possesses dinucleoside triphosphate hydrolase activity (By similarity), Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity), Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity), Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity), Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity), Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity), Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity), Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity), Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity), Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity), Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity), Functions as tumor suppressor (PubMed:10758156, PubMed:11517343)


This is Extracellular endo-inulinase inu2 protein, from Aspergillus ficuum, contains 516 amino acids, is soluble, locates in Extracellular.

Endo-inulinase involved in utilization of the plant storage polymer inulin, consisting of fructooligosaccharides with a degree of polymerization (DP) value from 2 to 60

Belongs to the glycosyl hydrolase 32 family


This is Eukaryotic translation initiation factor 3 subunit D protein, from Fission yeast, contains 567 amino acids, is soluble, locates in Cytoplasm.

mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs


This is Meiotic chromosome segregation protein P8B7.28c protein, from Fission yeast, contains 215 amino acids, locates in Nucleus.

Required for meiotic chromosome segregation