This is Protein decapentaplegic protein, from Fruit fly, contains 588 amino acids, is soluble, locates in Extracellular.

Required during oogenesis for eggshell patterning and dorsal/ventral patterning of the embryo, Acts as a morphogen during embryogenesis to pattern the dorsal/ventral axis, specifying dorsal ectoderm and amnioserosa cell fate within the dorsal half of the embryo; this activity is antagonized by binding to sog and tsg, Induces the formation of visceral mesoderm and the heart in early embryos, Required later in embryogenesis for dorsal closure and patterning of the hindgut, Also functions postembryonically as a long-range morphogen during imaginal disk development; is responsible for the progression of the morphogenetic furrow during eye development, Patterns the wing imaginal disk along its anterior/posterior axis and has a role in positioning pro-veins, Also required to subdivide the wing disk along the proximal/distal axis into body wall (notum) and wing, Ensures the correct architecture of wing epithelial cells, Has multiple roles in the developing tracheal system, controlling directed tracheal cell migration during embryogenesis and later specifying the fate of fusion cells in the tracheal branches, Required for viability of larvae, Essential for the maintenance and division of germline stem cells in the ovary, Signals via the type I receptor tkv, the type II receptor punt, and in some tissues via the type I receptor sax, in a signaling cascade that leads to activation and repression of target genes


This is Alpha-1-antitrypsin 1-1 protein, from Mouse, contains 413 amino acids, is soluble, locates in Extracellular.

Inhibitor of serine proteases, Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin


This is Cell division control protein 4 protein, from Baker's yeast, contains 779 amino acids, locates in Nucleus.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Recognizes and binds to phosphorylated target proteins, Directs ubiquitination of the phosphorylated CDK inhibitor SIC1, Involved in the degradation of CDC6 together with CDC34/UBC3 and CDC53, and in restricting the degradation of FAR1 to the nucleus, Is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle, It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation, Required for HTA1-HTB1 locus transcription activation, Required for G1/S and G2/M transition


This is Cytochrome b-c1 complex subunit Rieske, mitochondrial protein, from Baker's yeast, contains 215 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation, The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase, The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol, In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (Probable), The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster (PubMed:18390544), It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b (COB) to cytochrome c1 (CYT1) (PubMed:1657998, PubMed:2538628) (Probable)

Belongs to the Rieske iron-sulfur protein family


This is Carbonyl reductase [NADPH] 2 protein, from Mouse, contains 244 amino acids, is soluble, locates in Mitochondrion.

May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is E3 SUMO-protein ligase EGR2 protein, from Mouse, contains 470 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity

Belongs to the EGR C2H2-type zinc-finger protein family


This is Gamma-aminobutyric acid receptor subunit alpha-1 protein, from Bovine, contains 456 amino acids, is membrane-bound, locates in Cell membrane.

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:3037384), Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity), The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity), The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity), GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity), Functions also as histamine receptor and mediates cellular responses to histamine (By similarity)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Gamma-aminobutyric acid receptor (TC 1,A,9,5) subfamily, GABRA1 sub-subfamily


This is Gamma-aminobutyric acid receptor subunit beta-1 protein, from Bovine, contains 474 amino acids, is membrane-bound, locates in Cell membrane.

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain, Functions also as histamine receptor and mediates cellular responses to histamine (By similarity), Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site, Functions as ligand-gated chloride channel

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Gamma-aminobutyric acid receptor (TC 1,A,9,5) subfamily, GABRB1 sub-subfamily


This is Endochitinase A protein, from Common tobacco, contains 329 amino acids, locates in Lysosome/Vacuole.

Defense against chitin-containing fungal pathogens

Belongs to the glycosyl hydrolase 19 family, Chitinase class I subfamily


This is Phenylalanine--tRNA ligase, mitochondrial protein, from Baker's yeast, contains 469 amino acids, is soluble, locates in Mitochondrion.

Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation

Belongs to the class-II aminoacyl-tRNA synthetase family


This is Potassium voltage-gated channel protein Shaker protein, from Fruit fly, contains 655 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, The channel alternates between opened and closed conformations in response to the voltage difference across the membrane, Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents (PubMed:2448636), Plays a role in the regulation of sleep need or efficiency (PubMed:15858564), Plays a role in sexual behavior, where it is important for male sex discrimination (PubMed:22292044)

Belongs to the potassium channel family, A (Shaker) (TC 1,A,1,2) subfamily, Shaker sub-subfamily


This is Sulfate adenylyltransferase protein, from Baker's yeast, contains 511 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP, Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids

Belongs to the sulfate adenylyltransferase family


This is Ras-like protein 1 protein, from Fruit fly, contains 189 amino acids, is membrane-bound, locates in Cell membrane.

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity), Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells (PubMed:11290305), During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758)

Belongs to the small GTPase superfamily, Ras family


This is Vimentin protein, from Human, contains 466 amino acids, is soluble, locates in Cytoplasm.

Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2

Belongs to the intermediate filament family


This is Cytochrome P450 3A4 protein, from Human, contains 503 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids (PubMed:10681376, PubMed:11093772, PubMed:11555828, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:20702771, PubMed:19965576, PubMed:21490593, PubMed:21576599), Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase), Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:2732228, PubMed:14559847, PubMed:12865317, PubMed:15373842, PubMed:15764715, PubMed:21576599, PubMed:21490593), Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C-16 position (PubMed:11555828, PubMed:14559847, PubMed:12865317), Plays a role in the metabolism of androgens, particularly in oxidative deactivation of testosterone (PubMed:2732228, PubMed:15373842, PubMed:15764715, PubMed:22773874), Metabolizes testosterone to less biologically active 2beta- and 6beta-hydroxytestosterones (PubMed:2732228, PubMed:15373842, PubMed:15764715), Contributes to the formation of hydroxycholesterols (oxysterols), particularly A-ring hydroxylated cholesterol at the C-4beta position, and side chain hydroxylated cholesterol at the C-25 position, likely contributing to cholesterol degradation and bile acid biosynthesis (PubMed:21576599), Catalyzes bisallylic hydroxylation of polyunsaturated fatty acids (PUFA) (PubMed:9435160), Catalyzes the epoxidation of double bonds of PUFA with a preference for the last double bond (PubMed:19965576), Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:20702771), Plays a role in the metabolism of retinoids, Displays high catalytic activity for oxidation of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376), Further metabolizes atRA toward 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772), Responsible for oxidative metabolism of xenobiotics, Acts as a 2-exo-monooxygenase for plant lipid 1,8-cineole (eucalyptol) (PubMed:11159812), Metabolizes the majority of the administered drugs, Catalyzes sulfoxidation of the anthelmintics albendazole and fenbendazole (PubMed:10759686), Hydroxylates antimalarial drug quinine (PubMed:8968357), Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed:11695850), Also involved in vitamin D catabolism and calcium homeostasis, Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D(3)) (PubMed:29461981)


This is Keratin, type II cytoskeletal 7 protein, from Human, contains 469 amino acids, is soluble, locates in Cytoplasm.

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells, Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7)


This is Myosin regulatory light chain 2, ventricular/cardiac muscle isoform protein, from Rat, contains 166 amino acids, is soluble, locates in Cytoplasm.

Contractile protein that plays a role in heart development and function (By similarity), Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force, These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (PubMed:15331360), During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)


This is GTP:AMP phosphotransferase AK3, mitochondrial protein, from Bovine, contains 227 amino acids, is soluble, locates in Mitochondrion.

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates, Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities

Belongs to the adenylate kinase family, AK3 subfamily


This is Nucleoside diphosphate kinase protein, from Fruit fly, contains 153 amino acids, is soluble, locates in Cytoplasm.

Major role in the synthesis of nucleoside triphosphates other than ATP, The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate


This is 5-hydroxytryptamine receptor 1A protein, from Human, contains 422 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various drugs and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways, Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores, Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism, Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior, Plays a role in the response to anxiogenic stimuli

Belongs to the G-protein coupled receptor 1 family, 5-hydroxytryptamine receptor subfamily, HTR1A sub-subfamily


This is 5-hydroxytryptamine receptor 2C protein, from Rat, contains 460 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD), Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways, Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores, Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone, Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress, Plays a role in insulin sensitivity and glucose homeostasis

Belongs to the G-protein coupled receptor 1 family


This is Alpha-2A adrenergic receptor protein, from Human, contains 465 amino acids, is membrane-bound, locates in Cell membrane.

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins, The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine, For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol

Belongs to the G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2A sub-subfamily


This is Lamin Dm0 protein, from Fruit fly, contains 622 amino acids, locates in Nucleus.

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:3126192, PubMed:15035436), May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane (PubMed:15035436, PubMed:16439308), In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle (PubMed:27402967), Required for nuclear migration and to link the microtubule organizing center (MTOC) to the nucleus (PubMed:14617811), In addition, is required for nuclear envelope localization of klar (PubMed:14617811)


This is Serine protease inhibitor Kazal-type 1 protein, from Mouse, contains 80 amino acids, is soluble, locates in Extracellular.

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (PubMed:9828198, PubMed:14645103, PubMed:16083722, PubMed:22228629)


This is ATP-dependent RNA helicase vasa protein, from Fruit fly, contains 661 amino acids, is soluble, locates in Cytoplasm.

Involved in translational control mechanisms operating in early stages of oogenesis, Required maternally in many stages of oogenesis, including cystocyte differentiation, oocyte differentiation, and specification of anterior-posterior polarity in the developing cysts, Essential for the formation and/or structural integrity of perinuclear nuage particles during germ cell formation, Required for gus, Fsn and aub accumulation at the posterior pole of the embryo, Required for the localization of vas to the perinuclear region of nurse cells

Belongs to the DEAD box helicase family, DDX4/VASA subfamily


This is Homeotic protein caudal protein, from Fruit fly, contains 427 amino acids, locates in Nucleus.

Caudal (cad) is one of a number of transcription factors controlling segmentation of the embryo, Further transcriptional regulation via a 5' flanking region containing DNA replication-related elements (DRE) and by dref also regulated by trh and tgo via the CNS midline element, Alongside Bicoid (bcd), caudal forms concentration gradients down the anterior-posterior (A-P) axis providing positional information and subsequent induction of the gap genes, Plays a role in gastrulation/germ band extension, hindgut morphogenesis, positive regulation of cell proliferation, genital disk development and pattern formation, Acts as a key regulator of the Hox gene network and activates transcription via the downstream core promoter element (DPE) relative to the TATA box, Plays a role in the establishment of the hindgut and in the invagination of the hindgut primordium during gastrulation, These effects on the gut are achieved by acting combinatorially at the posterior of the embryo to activate transcription of different targets including fog, fkh and wg, Caudal is involved in regulation of proliferation through transactivation of the E2F gene, Postembryonically its function is mostly restricted to the intestine where it regulates antimicrobial peptide (AMP) levels preserving the normal gut flora


This is Cystatin-SA protein, from Human, contains 141 amino acids, is soluble, locates in Extracellular.


This is Alkaline extracellular protease protein, from Yeast, contains 454 amino acids, is soluble, locates in Extracellular.

Major secreted protein that belongs to the subtilisin family serine proteases


This is Galectin-1 protein, from Human, contains 135 amino acids, is soluble, locates in Extracellular.

Lectin that binds beta-galactoside and a wide array of complex carbohydrates, Plays a role in regulating apoptosis, cell proliferation and cell differentiation, Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase, Strong inducer of T-cell apoptosis


This is High mobility group protein B1 protein, from Human, contains 215 amino acids, locates in Cytoplasm.

(Microbial infection) Facilitates dengue virus propagation via interaction with the untranslated regions of viral genome, In turn, this interaction with viral RNA may regulate secondary structure of dengue RNA thus facilitating its recognition by the replication complex


This is C-1-tetrahydrofolate synthase, mitochondrial protein, from Baker's yeast, contains 975 amino acids, locates in Mitochondrion.

Mitochondrial isozyme of C-1-tetrahydrofolate synthase, The trifunctional enzyme catalyzes the interconversion of the one-carbon derivatives of tetrahydrofolate (THF) between different oxidation states by the enzymatic activities 10-formyltetrahydrofolate synthetase, 5,lO-methenyltetrahydrofolate cyclohydrolase, and 5,lO-methylenetetrahydrofolate dehydrogenase

In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family


This is Neuronal acetylcholine receptor subunit alpha-4 protein, from Rat, contains 630 amino acids, is membrane-bound, locates in Cell membrane.

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily, Alpha-4/CHRNA4 sub-subfamily


This is SPARC protein, from Human, contains 303 amino acids, is soluble, locates in Extracellular.

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines, Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes, There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity


This is Macrophage colony-stimulating factor 1 receptor protein, from Mouse, contains 977 amino acids, has 5 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes, Promotes the release of pro-inflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes, Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development, Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy, Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion, Activates several signaling pathways in response to ligand binding, including the ERK1/2 and the JNK pathway (By similarity), Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL, Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD, Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway, Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1, Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2, Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B, Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1, Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor, In the central nervous system, may play a role in the development of microglia macrophages (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily


This is Heme oxygenase 1 protein, from Human, contains 288 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron


This is Pheromone-processing carboxypeptidase KEX1 protein, from Baker's yeast, contains 729 amino acids, is membrane-bound, locates in Golgi apparatus.

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from the precursors of K1, K2 and K28 killer toxins and a-factor (mating pheromone), Involved in the programmed cell death caused by defective N-glycosylation and contributes also to the active cell death program induced by acetic acid stress or during chronological aging, Promotes cell fusion by proteolytically processing substrates that act in parallel to PRM1 as an alternative fusion machine, as cell wall components, or both


This is Serine protease inhibitor Kazal-type 1 protein, from Rat, contains 79 amino acids, is soluble, locates in Extracellular.

In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (By similarity)


This is Anaphase-promoting complex subunit CDC16 protein, from Baker's yeast, contains 840 amino acids, locates in Nucleus.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome, In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition, In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication


This is Interferon-induced protein with tetratricopeptide repeats 1 protein, from Human, contains 478 amino acids, is soluble, locates in Cytoplasm.

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs, Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection, Directly binds PPP-RNA in a non-sequence-specific manner, Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism), Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses


This is Ribonucleoside-diphosphate reductase small chain 1 protein, from Baker's yeast, contains 399 amino acids, locates in Nucleus.

Provides the precursors necessary for DNA synthesis, Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides, RNR2 provides the diiron-tyrosyl radical center

Belongs to the ribonucleoside diphosphate reductase small chain family


This is 5-aminolevulinate synthase, mitochondrial protein, from Baker's yeast, contains 548 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family


This is PBAN-type neuropeptides protein, from Silk moth, contains 192 amino acids, is soluble, locates in Extracellular.

The three SGNPS are far less active than DH in inducing diapause eggs, Beta-SGNP expressed higher pban activity than PBAN-I, but alpha- and gamma-SGNP were far less active in pheromonotropic activity


This is Wee1-like protein kinase 2 protein, from Human, contains 567 amino acids, locates in Nucleus.

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300), Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry, Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily


This is TCF3 fusion partner protein, from Human, contains 253 amino acids, locates in Nucleus.

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is Histone H2A-Bbd type 1 protein, from Human, contains 115 amino acids, locates in Nucleus.

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134), Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134), Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483), They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410), They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134)


This is Histone H2A-Bbd type 2/3 protein, from Human, contains 115 amino acids, locates in Nucleus.

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing, Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template, Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability, Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo, They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase, They associate with spliceosome components and are required for mRNA splicing, May participate in spermatogenesis


This is Proline-rich protein 7 protein, from Rat, contains 269 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (PubMed:27458189), Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189), Might play a redundant role in the regulation of T cell receptor signaling (By similarity), Might promote apoptosis in T cells (By similarity)


This is Ghrelin O-acyltransferase protein, from Mouse, contains 435 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Belongs to the membrane-bound acyltransferase family


This is Zinc metalloproteinase-disintegrin-like brevilysin H6 protein, from Korean slamosa snake, contains 610 amino acids, is soluble, locates in Extracellular.

Shows weak hemorrhagic activity, Rapidly degrades the alpha-chain of fibrinogen (FGA)

Belongs to the venom metalloproteinase (M12B) family, P-III subfamily, P-IIIb sub-subfamily


This is CDGSH iron-sulfur domain-containing protein 3, mitochondrial protein, from Human, contains 127 amino acids, locates in Mitochondrion.

Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2, Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function


This is Pentatricopeptide repeat-containing protein DWY1, chloroplastic protein, from Mouse-ear cress, contains 239 amino acids, locates in Plastid.

Plays a major role in single RNA editing events in chloroplasts, Acts as a site-recognition transacting factor involved in the edition of the site 1 of ndhD (ndhD-1 site corresponding to cytidine-2), which is a plastid-encoded subunit of the NADH-plastoquinone oxidoreductase, The interaction with CRR4 is required for its function in editing the ndhD-1 site

Belongs to the PPR family, PCMP-H subfamily


This is Basic phospholipase A2 BmTX-I protein, from Lance-headed viper, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that shows enzymatic activity in the presence of a synthetic substrate, In vitro, blocks the neuromuscular transmission in young chick biventer cervicis preparations, In mice, induces myonecrosis and a systemic interleukin-6 response upon intramuscular injection, Also induces edema and exerts a strong pro-inflammatory effect, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is Leucine-rich repeat-containing protein 4B protein, from Rat, contains 709 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Synaptic adhesion protein, Regulates the formation of excitatory synapses, The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner


This is Dermonecrotic toxin LiSicTox-alphaIA1a protein, from Brown spider, contains 306 amino acids, is soluble, locates in Extracellular.

Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity), This toxin acts on sphingomyelin (SM) with high activity (PubMed:16581177, PubMed:9790962, PubMed:21590705, PubMed:27233517), It also acts on lysophosphatidylcholine (LPC), and lyso-platelet activating factor (LPAF, an alkyl-LPC) but not on phosphatidylcholine (PC) (PubMed:21590705, PubMed:27233517), It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity), It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity), In vivo, it induces dermonecrosis, vascular permeability, platelet aggregation, inflammatory response, edema and cytotoxicity against renal epithelial cells (PubMed:16581177, PubMed:9790962, PubMed:17900646, PubMed:27233517), It causes direct nephrotoxicity (PubMed:16005484) and is directly toxic to liver (PubMed:18765244), It also induces hemolysis in a complement-dependent manner as well as in a complement-independent manner (PubMed:9790962, PubMed:17900646, PubMed:21590705, PubMed:27233517), The hemolysis provoked in a complement-independent manner is composed of several steps (PubMed:21590705), The toxin binds to erythrocyte membranes, hydrolyzes membrane phospholipids (SM and LPC) thus generating metabolism products that cause hemolysis, probably by provoking an increase of calcium inside cells (PubMed:21590705), The calcium influx is due to the opening of L-type calcium channels, since L-type calcium channel blockers inhibit calcium influx (PubMed:21590705), In vivo, is lethal to mice when intraperitoneally injected (PubMed:17900646)

Belongs to the arthropod phospholipase D family, Class II subfamily, Class IIa sub-subfamily


This is Dermonecrotic toxin LiSicTox-alphaIA1bi protein, from Brown spider, contains 306 amino acids, is soluble, locates in Extracellular.

Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity), This toxin acts on sphingomyelin (SM) (PubMed:15234562, PubMed:9790962, PubMed:16934304), The level of enzymatic activity is high according to Tambourgi and colleagues or low according to Felicori and colleagues (PubMed:15234562, PubMed:16934304), It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity), It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity), It induces complement-dependent hemolysis, dermonecrosis, vascular permeability and platelet aggregation (PubMed:15234562, PubMed:9790962, PubMed:16934304), Both C5a and the membrane attack complex may play a role in the induction of dermonecrosis, MMP-9 and MMP-2 produced by skin fibroblasts can also contribute to proteolytic tissue destruction


This is Dermonecrotic toxin LiSicTox-alphaIA2ai protein, from Brown spider, contains 306 amino acids, is soluble, locates in Extracellular.

Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity), This toxin acts on sphingomyelin (SM) (PubMed:15234562, PubMed:9790962), It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity), It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity), It induces complement-dependent hemolysis, dermonecrosis, vascular permeability and platelet aggregation (PubMed:15234562, PubMed:9790962)


This is Mitotic-spindle organizing protein 1 protein, from Fission yeast, contains 64 amino acids, is soluble, locates in Cytoplasm.

Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC)


This is RBPJ-interacting and tubulin-associated protein 1 protein, from African clawed frog, contains 239 amino acids, locates in Cytoplasm.

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway, Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of rbpj/rbpsuh, thereby preventing the interaction between rbpj/rbpsuh and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription, May play a role in neurogenesis


This is Candidapepsin-2 protein, from Yeast, contains 398 amino acids, is soluble, locates in Extracellular.


This is Protease B inhibitor 2 protein, from Baker's yeast, contains 75 amino acids, is soluble, locates in Cytoplasm.

Cytosolic inhibitor of vacuolar proteinase B (yscB), probably regulating protease B activity during limited proteolysis, PBI2 is a component of the LMA1 complex, which is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi

Belongs to the protease inhibitor I9 family


This is Cadmium/zinc-transporting ATPase HMA3 protein, from Mouse-ear cress, contains 760 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

In a heterologous system, involved in cadmium and lead transport, but not in zinc transport, May have a detoxification function through a vacuolar sequestration

Belongs to the cation transport ATPase (P-type) (TC 3,A,3) family, Type IB subfamily


This is Large ribosomal subunit protein eL42A protein, from Baker's yeast, contains 106 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL42 family


This is Large ribosomal subunit protein eL42B protein, from Baker's yeast, contains 106 amino acids, is soluble, locates in Cytoplasm.


This is Small ribosomal subunit protein uS12A protein, from Baker's yeast, contains 145 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uS12 family


This is Small ribosomal subunit protein uS12B protein, from Baker's yeast, contains 145 amino acids, is soluble, locates in Cytoplasm.


This is Small ribosomal subunit protein eS4A protein, from Baker's yeast, contains 261 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eS4 family


This is Small ribosomal subunit protein eS4B protein, from Baker's yeast, contains 261 amino acids, is soluble, locates in Cytoplasm.


This is Small ribosomal subunit protein eS8A protein, from Baker's yeast, contains 200 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eS8 family


This is Small ribosomal subunit protein eS8B protein, from Baker's yeast, contains 200 amino acids, is soluble, locates in Cytoplasm.


This is Large ribosomal subunit protein uL1A protein, from Baker's yeast, contains 217 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel, uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA

Belongs to the universal ribosomal protein uL1 family


This is Large ribosomal subunit protein uL1B protein, from Baker's yeast, contains 217 amino acids, is soluble, locates in Cytoplasm.


This is Large ribosomal subunit protein uL2A protein, from Baker's yeast, contains 254 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uL2 family


This is Small ribosomal subunit protein uS17A protein, from Baker's yeast, contains 156 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uS17 family


This is Small ribosomal subunit protein uS17B protein, from Baker's yeast, contains 156 amino acids, is soluble, locates in Cytoplasm.


This is Large ribosomal subunit protein eL18B protein, from Baker's yeast, contains 186 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eL18 family


This is Small ribosomal subunit protein uS9A protein, from Baker's yeast, contains 143 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uS9 family


This is Large ribosomal subunit protein uL11A protein, from Baker's yeast, contains 165 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uL11 family


This is Large ribosomal subunit protein uL11B protein, from Baker's yeast, contains 165 amino acids, is soluble, locates in Cytoplasm.


This is Small ribosomal subunit protein uS13A protein, from Baker's yeast, contains 146 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uS13 family


This is Small ribosomal subunit protein uS13B protein, from Baker's yeast, contains 146 amino acids, is soluble, locates in Cytoplasm.


This is Candidapepsin-1 protein, from Yeast, contains 391 amino acids, is soluble, locates in Extracellular.

Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors, These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense, Induces host inflammatory cytokine production in a proteolytic activity-independent way, Plays a role in tissue damage during superficial infection, Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein


This is Acyl-coenzyme A oxidase 3, peroxisomal protein, from Mouse-ear cress, contains 675 amino acids, locates in Peroxisome.

Catalyzes the desaturation of medium-chain acyl-CoAs to 2-trans-enoyl-CoAs, Active on C8:0- to C14:0-CoA with a maximal activity on C12:0-CoA


This is Ras-related protein Rab-34, isoform NARR protein, from Human, contains 198 amino acids, locates in Nucleus.


This is Candidapepsin-2 protein, from Yeast, contains 398 amino acids, is soluble, locates in Extracellular.


This is RNA-binding motif protein, Y chromosome, family 1 member A1 protein, from Human, contains 496 amino acids, locates in Nucleus.

RNA-binding protein involved in pre-mRNA splicing, Required for sperm development, Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN, Binds non-specifically to mRNAs


This is RNA-binding motif protein, Y chromosome, family 1 member C protein, from Human, contains 496 amino acids, locates in Nucleus.


This is Foxo1-corepressor protein, from Mouse, contains 106 amino acids, locates in Cytoplasm.

Regulator of adipocytes that acts by repressing FOXO1 transcriptional activity, Acts by promoting acetylation of FOXO1, both by preventing the interaction between FOXO1 and SIRT1 deacetylase, and by mediating acetyltransferase activity in vitro, Regulates insulin sensitivity and energy metabolism


This is Mambalgin-1 protein, from Black mamba, contains 78 amino acids, is soluble, locates in Extracellular.

This three-finger toxin inhibits ASIC channels, It acts as a gating modifier toxin by decreasing the apparent proton sensitivity of activation and by slightly increasing the apparent proton sensitivity for inactivation (PubMed:23034652), It binds more tightly to the closed state and to a much lesser extent the inactivated/desensitized state of ASIC1a isoform of ASIC1 (PubMed:23034652), It interacts directly with the outside surface of the thumb domain of chicken ASIC1a (ASIC1a), but does not insert into the acidic pocket as suggested for mambalgin-2 (PubMed:29872539), This binding leads to relocation of the thumb domain that could disrupt the acidic pocket of cASIC1a (PubMed:29872539), It reversibly inhibits rat ASIC1a (IC(50)=3,4-55 nM), rat ASIC1a-ASIC2b (IC(50)=61 nM), rat ASIC1a-ASIC1b (IC(50)=72 nM), human ASIC1a (IC(50)=127-580 nM), chicken ASIC1a (IC(50)=123,6 nM), rat ASIC1b (IC(50)=22,2-203 nM), rat ASIC1a-ASIC2a (IC(50)=152-252 nM) (PubMed:23034652, PubMed:23624383, PubMed:25873388, PubMed:24619065, PubMed:26680001, PubMed:29872539), In vivo, it shows a potent naloxone-resistant analgesic effect against acute and inflammatory pain upon central and peripheral injection (PubMed:23034652), In addition, it also has an opioid-independent effect on both thermal and mechanical inflammatory pain after systemic administration and is effective against neuropathic pain (PubMed:26680001)

Belongs to the snake three-finger toxin family, Short-chain subfamily, Mambalgin sub-subfamily


This is Heat shock 70 kDa protein 1A protein, from Human, contains 641 amino acids, is soluble, locates in Cytoplasm.

(Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell

Belongs to the heat shock protein 70 family


This is Heat shock 70 kDa protein 1B protein, from Human, contains 641 amino acids, is soluble, locates in Cytoplasm.


This is Choriogonadotropin subunit beta 3 protein, from Human, contains 165 amino acids, is soluble, locates in Extracellular.

Beta subunit of the human chorionic gonadotropin (hCG), hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated, The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH), The beta subunits are distinct in each of the hormones and confer receptor and biological specificity, Has an essential role in pregnancy and maternal adaptation, Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Belongs to the glycoprotein hormones subunit beta family


This is ATP-dependent RNA helicase eIF4A protein, from Baker's yeast, contains 395 amino acids, is soluble, locates in Cytoplasm.

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome, In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon

Belongs to the DEAD box helicase family, eIF4A subfamily


This is Adrenodoxin, mitochondrial protein, from Human, contains 184 amino acids, is soluble, locates in Mitochondrion.

Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783), Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783), Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783), Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity)

Belongs to the adrenodoxin/putidaredoxin family


This is Alcohol dehydrogenase 4 protein, from Baker's yeast, contains 382 amino acids, locates in Mitochondrion.

Reduces acetaldehyde to ethanol during glucose fermentation, Specific for ethanol, Shows drastically reduced activity towards primary alcohols from 4 carbon atoms upward, Isomers of aliphatic alcohol, as well as secondary alcohols and glycerol are not used at all

Belongs to the iron-containing alcohol dehydrogenase family


This is RNA-binding protein RO60 protein, from Human, contains 538 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853), Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853), Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853), May play roles in cilia formation and/or maintenance (By similarity)


This is Homeobox protein rough protein, from Fruit fly, contains 350 amino acids, locates in Nucleus.

Required to establish the unique cell identity of photoreceptors R2 and R5 and consequently for ommatidial assembly in the developing eye imaginal disk, Repression of expression in R8 photoreceptor by senseless (sens) is an essential mechanism of R8 cell fate determination


This is Transcriptional activator Myb protein, from Human, contains 640 amino acids, locates in Nucleus.

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3', Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells


This is Lysosomal alpha-glucosidase protein, from Human, contains 952 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Essential for the degradation of glycogen in lysosomes (PubMed:1856189, PubMed:7717400, PubMed:14695532, PubMed:18429042), Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans (PubMed:29061980)

Belongs to the glycosyl hydrolase 31 family


This is Protein ovarian tumor locus protein, from Fruit fly, contains 853 amino acids, is soluble, locates in Cytoplasm.

Essential for female fertility; germ cell division and differentiation


This is Nuclear receptor subfamily 2 group F member 6 protein, from Human, contains 404 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Transcription factor predominantly involved in transcriptional repression, Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors, Involved in modulation of hormonal responses, Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene, Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner, The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6, Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity, Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity, Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Large ribosomal subunit protein P1B protein, from Baker's yeast, contains 106 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein P1/P2 family


This is Protein twist protein, from Fruit fly, contains 490 amino acids, locates in Nucleus.

Involved in the establishment and dorsoventral patterning of germ layers in the embryo


This is Cytochrome P450 2D6 protein, from Human, contains 497 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599), Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599), Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997), Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075), Catalyzes the hydroxylation of carbon-hydrogen bonds, Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599), Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376), Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants


This is cAMP-dependent protein kinase type I-alpha regulatory subunit protein, from Human, contains 381 amino acids, is membrane-bound, locates in Cell membrane.

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

Belongs to the cAMP-dependent kinase regulatory chain family


This is Ribulose bisphosphate carboxylase small subunit 1A, chloroplastic protein, from Mouse-ear cress, contains 180 amino acids, is membrane-bound, locates in Plastid.

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate, Both reactions occur simultaneously and in competition at the same active site, Although the small subunit is not catalytic it is essential for maximal activity

Belongs to the RuBisCO small chain family


This is Guanine nucleotide-binding protein alpha-2 subunit protein, from Baker's yeast, contains 449 amino acids, is membrane-bound, locates in Cell membrane.

Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) involved in glucose-induced cAMP signaling, Binds to its cognate transmembrane receptor GPR1, which senses extracellular carbon sources, and activates cAMP-PKA signaling and governs diploid pseudohyphal differentiation and haploid invasive growth, The G protein beta-mimic proteins GPB1 and GPB2 inhibit GPA2-GPR1 coupling, probably to reduce signaling in the absence of glucose

Belongs to the G-alpha family, G(q) subfamily


This is Postreplication repair E3 ubiquitin-protein ligase RAD18 protein, from Baker's yeast, contains 487 amino acids, has 1 RING-type Zinc finger, has 1 UBZ4-type Zinc finger, locates in Nucleus.

RING-type

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group, Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA, The UBC2-RAD18 complex cooperates with RAD5 and the UBC13-MMS2 dimer to attach mono-ubiquitin chains on 'Lys-164' of POL30, which is necessary for PRR, The UBC2-RAD18 complex is also involved in prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine


This is Low glucose sensor SNF3 protein, from Baker's yeast, contains 884 amino acids, is membrane-bound, locates in Cell membrane.

High-affinity low glucose sensor that is part of the sensor/receptor-repressor (SSR) glucose-signaling pathway, which detects extracellular glucose and induces expression of glucose transporters that bring glucose into the cell (PubMed:8901598, PubMed:9564039), The transporter-like sensor generates an intracellular signal in the presence of low levels of glucose to promote low glucose-induced expression of HXT2 (PubMed:9564039), Binding of glucose to the SNF3 transmembrane domain activates a downstream signaling cascade, leading to phosphorylation of the RGT1 corepressors MTH1 and STD1, targeting them for SCF(Grr1)-dependent ubiquitination and degradation, Depletion of the corepressors robs RGT1 of its ability to repress expression of HXT genes, leading to accumulation of glucose transporters in the plasma membrane (By similarity), SNF3 is involved as well in the transport of mannose and fructose (PubMed:20014043), Even though SNF3 is similar to glucose transporters, it appears to be unable to transport glucose (PubMed:9564039)

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family


This is Islet amyloid polypeptide protein, from Human, contains 89 amino acids, is soluble, locates in Extracellular.

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism


This is Nuclear transition protein 2 protein, from Rat, contains 114 amino acids, locates in Nucleus.

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:11772016), In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (By similarity)

Belongs to the nuclear transition protein 2 family


This is Lysosomal acid phosphatase protein, from Human, contains 423 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Belongs to the histidine acid phosphatase family


This is Solute carrier family 2, facilitated glucose transporter member 3 protein, from Human, contains 496 amino acids, is membrane-bound, locates in Cell membrane.

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916), Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916), Does not mediate fructose transport (PubMed:9477959, PubMed:26176916)

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily


This is Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial protein, from Bovine, contains 482 amino acids, is soluble, locates in Mitochondrion.

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2), It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3), Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component

Belongs to the 2-oxoacid dehydrogenase family


This is Mannose-binding protein C protein, from Human, contains 248 amino acids, is soluble, locates in Extracellular.

Calcium-dependent lectin involved in innate immune defense (PubMed:35102342), Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway, Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages, May bind DNA, Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342)


This is Ras-related protein Ral-B protein, from Human, contains 206 amino acids, is membrane-bound, locates in Cell membrane.

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking (PubMed:10393179, PubMed:17875936, PubMed:18756269), Accomplishes its multiple functions by interacting with distinct downstream effectors, Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity), Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity), Required for suppression of apoptosis (PubMed:17875936), In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission (PubMed:18756269), Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors (PubMed:10393179)

Belongs to the small GTPase superfamily, Ras family


This is Oxygen-dependent coproporphyrinogen-III oxidase protein, from Baker's yeast, contains 328 amino acids, is soluble, locates in Cytoplasm.

Involved in the heme biosynthesis, Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX

Belongs to the aerobic coproporphyrinogen-III oxidase family


This is DNA topoisomerase 1 protein, from Human, contains 765 amino acids, is soluble, locates in Nucleus.

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex, Introduces a single-strand break via transesterification at a target site in duplex DNA, The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand, The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils, Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity), Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells, Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter

Belongs to the type IB topoisomerase family


This is Ubiquitin-like protein 4A protein, from Human, contains 157 amino acids, is soluble, locates in Cytoplasm.

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892), The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane, Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373), Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892), Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475), The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome, It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303)


This is Steroid hormone receptor ERR1 protein, from Human, contains 423 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3', Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter, Binds to the C1 region of the lactoferrin gene promoter, Requires dimerization and the coactivator, PGC-1A, for full activity, The ERRalpha/PGC1alpha complex is a regulator of energy metabolism, Induces the expression of PERM1 in the skeletal muscle

Belongs to the nuclear hormone receptor family, NR3 subfamily


This is V-type proton ATPase subunit B1 protein, from Mouse-ear cress, contains 486 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase, V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Belongs to the ATPase alpha/beta chains family


This is Integrin beta-PS protein, from Fruit fly, contains 846 amino acids, is membrane-bound, locates in Cell membrane.

Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082), Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786), Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969), Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969), The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969), Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969), Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:8119134, PubMed:7924982, PubMed:7972082, PubMed:10821184), Involved in the function and/or development of the olfactory system (PubMed:10821184), In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715), Plays a role in timely border cell migration during oogenesis (PubMed:19035354)

Belongs to the integrin beta chain family


This is Non-histone chromosomal protein 6B protein, from Baker's yeast, contains 99 amino acids, locates in Nucleus.

DNA-binding protein that induces severe bending of DNA, Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes, The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair, Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex, Required for transcriptional initiation fidelity of some but not all tRNA genes, Seems to be functionally redundant with NHP6A


This is Cytochrome P450 2C9 protein, from Human, contains 490 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599), Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599), Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708), Catalyzes the hydroxylation of carbon-hydrogen bonds, Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599), Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317), Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160), Also metabolizes plant monoterpenes such as limonene, Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794), Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031)


This is Transcription initiation factor TFIID subunit 13 protein, from Baker's yeast, contains 167 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID, Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription


This is B-lymphocyte antigen CD20 protein, from Human, contains 297 amino acids, is membrane-bound, locates in Cell membrane.

B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes (PubMed:3925015, PubMed:7684739, PubMed:12920111), Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR (PubMed:7684739, PubMed:12920111, PubMed:18474602)


This is Acyl-coenzyme A diphosphatase NUDT19 protein, from Mouse, contains 357 amino acids, locates in Peroxisome.

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:16185196, PubMed:29378847), Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (PubMed:16185196, PubMed:29378847), Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (PubMed:16185196), Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673)


This is Proliferating cell nuclear antigen protein, from Human, contains 261 amino acids, locates in Nucleus.

Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232), Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities, Has to be loaded onto DNA in order to be able to stimulate APEX2, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902), Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737)


This is Isovaleryl-CoA dehydrogenase, mitochondrial protein, from Rat, contains 424 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway, To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA

Belongs to the acyl-CoA dehydrogenase family


This is Metalloproteinase inhibitor 1 protein, from Mouse, contains 205 amino acids, is soluble, locates in Extracellular.

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor, Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16, Does not act on MMP14 (By similarity), Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1, Plays a role in integrin signaling

Belongs to the protease inhibitor I35 (TIMP) family


This is Solute carrier family 25 member 3 protein, from Bovine, contains 362 amino acids, is membrane-bound, locates in Mitochondrion.

Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (PubMed:9712911) (By similarity), Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (PubMed:9712911), Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (By similarity), May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is High affinity immunoglobulin gamma Fc receptor I protein, from Human, contains 374 amino acids, has 3 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

High affinity receptor for the Fc region of immunoglobulins gamma, Functions in both innate and adaptive immune responses, Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells

Belongs to the immunoglobulin superfamily, FCGR1 family


This is Low affinity immunoglobulin gamma Fc region receptor II-a protein, from Human, contains 317 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Binds to the Fc region of immunoglobulins gamma, Low affinity receptor, By binding to IgG it initiates cellular responses against pathogens and soluble antigens, Promotes phagocytosis of opsonized antigens


This is Eukaryotic peptide chain release factor subunit 1 protein, from Baker's yeast, contains 437 amino acids, is soluble, locates in Cytoplasm.

Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons (PubMed:7556078, PubMed:20947765, PubMed:34413231), The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site (PubMed:7556078, PubMed:20947765), SUP45/eRF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA (PubMed:7556078, PubMed:20947765, PubMed:34413231), Following GTP hydrolysis by SUP35/eRF3, SUP35/eRF3 dissociates, permitting SUP45/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA (PubMed:7556078, PubMed:20947765, PubMed:34413231)

Belongs to the eukaryotic release factor 1 family


This is Protein L-Myc protein, from Human, contains 364 amino acids, locates in Nucleus.


This is Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial protein, from Baker's yeast, contains 482 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)


This is Fibrinogen gamma-B chain protein, from Bovine, contains 444 amino acids, is soluble, locates in Extracellular.

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix, Has a major function in hemostasis as one of the primary components of blood clots, In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization, Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood, However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo, Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway, Maternal fibrinogen is essential for successful pregnancy, Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage, May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways


This is N-terminal acetyltransferase A complex subunit NAT1 protein, from Baker's yeast, contains 854 amino acids, is soluble, locates in Cytoplasm.

Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala, N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover, NAT1 anchors ARD1 and NAT5 to the ribosome and may present the N termini of nascent polypeptides for acetylation


This is X-ray repair cross-complementing protein 6 protein, from Human, contains 609 amino acids, locates in Nucleus.

Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108), Required for double-strand break repair and V(D)J recombination (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108), Also has a role in chromosome translocation (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108), Has a role in chromosome translocation (PubMed:7957065, PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:8621488, PubMed:12145306, PubMed:11493912), The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner (PubMed:7957065, PubMed:8621488, PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:12145306, PubMed:11493912), It works in the 3'-5' direction (PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912), During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection (PubMed:7957065, PubMed:8621488, PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:12145306, PubMed:11493912), Binding to DNA may be mediated by XRCC6 (PubMed:20493174, PubMed:2466842, PubMed:9742108, PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912), The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108), The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108), The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912, PubMed:20493174, PubMed:2466842, PubMed:9742108), Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks (PubMed:20383123), 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined (PubMed:20383123), The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488), In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:12145306), Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728)


This is Cap-associated protein CAF20 protein, from Baker's yeast, contains 161 amino acids, is soluble, locates in Cytoplasm.

Acts as an inhibitor of cap-dependent translation, Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA, Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631, Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation


This is Stearoyl-CoA desaturase 2 protein, from Mouse, contains 358 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:16443825), Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:16443825), Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:16443825), Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates (PubMed:16118274), Important for normal permeability barrier function of the skin in neonates (PubMed:16118274)

Belongs to the fatty acid desaturase type 1 family


This is Interferon-induced transmembrane protein 1 protein, from Human, contains 125 amino acids, is membrane-bound, locates in Cell membrane.

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol, Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) (PubMed:26354436, PubMed:33270927), Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry, Also implicated in cell adhesion and control of cell growth and migration (PubMed:33270927), Inhibits SARS-CoV-2 S protein-mediated syncytia formation (PubMed:33051876), Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner, Acts as a positive regulator of osteoblast differentiation, In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436), IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436)


This is Teratocarcinoma-derived growth factor 1 protein, from Human, contains 188 amino acids, is membrane-bound, locates in Cell membrane.

GPI-anchored cell membrane protein involved in Nodal signaling, Cell-associated TDGF1 acts as a Nodal coreceptor in cis, Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714), Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953)

Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family


This is Cytochrome b-245 light chain protein, from Human, contains 195 amino acids, is membrane-bound, locates in Cell membrane.

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide, Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide


This is Acyl-CoA desaturase 1 protein, from Mouse, contains 355 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates, Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:11500518, PubMed:11533264, PubMed:16275639, PubMed:16443825, PubMed:26098370), Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:11500518, PubMed:11533264, PubMed:16443825, PubMed:26098370), Plays an important role in lipid biosynthesis (PubMed:17127673, PubMed:10899171, PubMed:11500518, PubMed:11441127, PubMed:11533264, PubMed:12177411, PubMed:26098370), Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (PubMed:12177411, PubMed:17127673, PubMed:24356954, PubMed:24295027), Plays an important role in body energy homeostasis (PubMed:17127673, PubMed:15210843, PubMed:24295027, PubMed:24356954), Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:10899171, PubMed:11500518, PubMed:11441127, PubMed:11533264, PubMed:12177411, PubMed:15210843, PubMed:26098370), Required for normal development of sebaceous glands (PubMed:17738154, PubMed:11533264), Required for the biosynthesis of normal levels of Delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland (PubMed:11500518), Required for normal production of meibum, an oily material that prevents drying of the cornea (PubMed:11533264)


This is Serine protease easter protein, from Fruit fly, contains 392 amino acids, is soluble, locates in Extracellular.

Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo (PubMed:9477324, PubMed:2107028, PubMed:12493753), Three proteases; ndl, gd and snk process easter to create active easter (PubMed:9477324), Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo (PubMed:9477324)

Belongs to the peptidase S1 family, CLIP subfamily


This is Auxin-binding protein 1 protein, from Maize, contains 201 amino acids, is soluble, locates in Endoplasmic reticulum.


This is Translationally-controlled tumor protein protein, from Human, contains 172 amino acids, is soluble, locates in Cytoplasm.

Involved in calcium binding and microtubule stabilization (PubMed:12167714, PubMed:15162379, PubMed:15958728), Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein (PubMed:18325344)


This is Beta-hexosaminidase subunit A1 protein, from Social amoeba, contains 532 amino acids, locates in Lysosome/Vacuole.

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, This enzyme plays a role during the slug stage of development in the maintenance of pseudoplasmodia of normal size

Belongs to the glycosyl hydrolase 20 family


This is General transcription factor IIF subunit 2 protein, from Human, contains 249 amino acids, locates in Nucleus.

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB

Belongs to the TFIIF beta subunit family


This is Large ribosomal subunit protein uL3 protein, from Baker's yeast, contains 387 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:24865971, PubMed:22096102), The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:22096102), The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:22096102), The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102), uL3 plays a role in coordinating processes of accommodating the aminoacyl-tRNA in the PTC (PubMed:22096102)

Belongs to the universal ribosomal protein uL3 family


This is Glial fibrillary acidic protein protein, from Human, contains 432 amino acids, is soluble, locates in Cytoplasm.

GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells

Belongs to the intermediate filament family


This is ARS-binding factor 1 protein, from Baker's yeast, contains 731 amino acids, locates in Nucleus.

General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure, Involved in the transcription activation of a subset of ribosomal protein genes, Binds the ARS-elements found in many promoters, Binds to the sequence 5'-TCN(7)ACG-3', Influences on genome-wide nucleosome occupancy and affects chromatin structure, and probably dynamics, As a component of the global genome repair (GGR) complex, promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA, Component of the regulatory network controlling mitotic and meiotic cell cycle progression