This is Squalene synthase ERG9 protein, from Baker's yeast, contains 444 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:1807826, PubMed:2068081, PubMed:8323279, PubMed:9742963), ERG9 produces squalene from 2 farnesyl pyrophosphate moieties (PubMed:1807826, PubMed:8323279), The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane, Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids, Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis, Secondly, the squalene epoxidase ERG1 catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, which is considered to be a rate-limiting enzyme in steroid biosynthesis, Then, the lanosterol synthase ERG7 catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol core, In the next steps, lanosterol is transformed to zymosterol through a complex process involving various demethylation, reduction and desaturation reactions, The lanosterol 14-alpha-demethylase ERG11 (also known as CYP51) catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, which is critical for ergosterol biosynthesis, The C-14 reductase ERG24 reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol, 4,4-dimethyl-cholesta-8,24-dienol is substrate of the C-4 demethylation complex ERG25-ERG26-ERG27 in which ERG25 catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, ERG26 catalyzes the oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group, and ERG27 is responsible for the reduction of the keto group on the C-3, ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum and ERG29 regulates the activity of the iron-containing C4-methylsterol oxidase ERG25, Then, the sterol 24-C-methyltransferase ERG6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol, The C-8 sterol isomerase ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol, The sterol-C5-desaturase ERG3 then catalyzes the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol, The C-22 sterol desaturase ERG5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain, Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (PubMed:32679672)

Belongs to the phytoene/squalene synthase family


This is Glucan 1,3-beta-glucosidase protein, from Yeast, contains 438 amino acids, is soluble, locates in Extracellular.

Major glucan 1,3-beta-glucosidase required for cell wall integrity, Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall, Can also function biosynthetically as a transglycosylase, Functions to deliver glucan from the cell to the extracellular matrix, Does not appear to impact cell wall glucan content of biofilm cells, nor is it necessary for filamentation or biofilm formation, Involved in cell-substrate and cell-cell adhesion, Adhesion to host-cell surfaces is the first critical step during mucosal infection, XOG1 is target of human antimicrobial peptide LL-37 for inhibition of cell adhesion

Belongs to the glycosyl hydrolase 5 (cellulase A) family


This is Aquaporin-1 protein, from Human, contains 269 amino acids, is membrane-bound, locates in Cell membrane.

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:1373524), Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865)

Belongs to the MIP/aquaporin (TC 1,A,8) family


This is Flavin reductase (NADPH) protein, from Human, contains 206 amino acids, is soluble, locates in Cytoplasm.

Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone), Contributes to heme catabolism and metabolizes linear tetrapyrroles, Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH, In the liver, converts biliverdin to bilirubin


This is Metalloproteinase inhibitor 1 protein, from Rat, contains 217 amino acids, is soluble, locates in Extracellular.

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor, Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16, Does not act on MMP14, Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1, Plays a role in integrin signaling, Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity

Belongs to the protease inhibitor I35 (TIMP) family


This is High affinity immunoglobulin epsilon receptor subunit gamma protein, from Human, contains 86 amino acids, is membrane-bound, locates in Cell membrane.

Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors, As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells, As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset, Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells, Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes, May function cooperatively with other activating receptors, Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation, Also involved in integrin alpha-2/ITGA2-mediated platelet activation


This is Aquaporin PIP2-3 protein, from Mouse-ear cress, contains 285 amino acids, is membrane-bound, locates in Cell membrane.

Water channel required to facilitate the transport of water across cell membrane; mercury-insensitive

Belongs to the MIP/aquaporin (TC 1,A,8) family, PIP (TC 1,A,8,11) subfamily


This is M-phase inducer phosphatase 2 protein, from Human, contains 580 amino acids, is soluble, locates in Cytoplasm.

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression, Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner, Directly dephosphorylates CDK1 and stimulates its kinase activity, The three isoforms seem to have a different level of activity


This is Muscarinic acetylcholine receptor M2 protein, from Chicken, contains 466 amino acids, is membrane-bound, locates in Cell membrane.

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins, Primary transducing effect is adenylate cyclase inhibition, Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol

Belongs to the G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM2 sub-subfamily


This is Peptidyl-prolyl cis-trans isomerase F, mitochondrial protein, from Human, contains 207 amino acids, is soluble, locates in Mitochondrion.

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357), Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:26387735), It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated (PubMed:26387735), In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis (PubMed:22726440), Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels (By similarity), Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis (PubMed:19228691)

Belongs to the cyclophilin-type PPIase family


This is Peptidyl-prolyl cis-trans isomerase FKBP4 protein, from Mouse, contains 458 amino acids, locates in Cytoplasm.

Immunophilin protein with PPIase and co-chaperone activities, Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90), May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening, Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly, May have a protective role against oxidative stress in mitochondria


This is Tyrosine-protein kinase receptor UFO protein, from Human, contains 894 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

(Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed:28076778, PubMed:29379210, PubMed:31311882), Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed:28076778), Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed:29379210)

Belongs to the protein kinase superfamily, Tyr protein kinase family, AXL/UFO subfamily


This is Histamine H1 receptor protein, from Bovine, contains 491 amino acids, is membrane-bound, locates in Cell membrane.

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system

Belongs to the G-protein coupled receptor 1 family


This is cAMP-dependent protein kinase regulatory subunit protein, from Caenorhabditis elegans, contains 366 amino acids, is soluble, locates in Cytoplasm.

Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons

Belongs to the cAMP-dependent kinase regulatory chain family


This is Chromobox protein homolog 2 protein, from Mouse, contains 519 amino acids, locates in Nucleus.

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity), PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity), Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (PubMed:16537902), Plays a role in the lineage differentiation of the germ layers in embryonic development (PubMed:22226355), Involved in sexual development, acting as activator of NR5A1 expression (By similarity)


This is DNA replication licensing factor mcm4-B protein, from African clawed frog, contains 863 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity


This is Cohesin subunit rad21 protein, from Fission yeast, contains 628 amino acids, locates in Nucleus.

Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, The cohesin complex is required for the cohesion of sister chromatids after DNA replication, The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped, At metaphase-anaphase transition, this protein is cleaved by cut1 and dissociates from chromatin, allowing sister chromatids to segregate, Also involved in the DNA double-strand-break (DSB) repair system


This is High affinity cationic amino acid transporter 1 protein, from Human, contains 629 amino acids, is membrane-bound, locates in Cell membrane.

High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues

Belongs to the amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2,A,3,3) family


This is 5-hydroxytryptamine receptor 1F protein, from Human, contains 366 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling inhibits adenylate cyclase activity


This is ADP,ATP carrier protein 1, mitochondrial protein, from Mouse-ear cress, contains 381 amino acids, is membrane-bound, locates in Mitochondrion.

ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity), Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Translationally-controlled tumor protein 1 protein, from Mouse-ear cress, contains 168 amino acids, is soluble, locates in Cytoplasm.

General regulator required for the development of the entire plant, Regulates the duration of cell cycle (PubMed:20736351), Probable activator of Rab GTPases and upstream regulator of the cell growth-regulating TOR (target of rapamycin) network (PubMed:19060111, PubMed:20736351), Might also control spatial growth in pollen tubes or root hairs via the TORC2 signaling branch (PubMed:19060111), Involved in the regulation of abscisic acid- and calcium-mediated stomatal closure, but not in light or H(+)-pumping induced stomatal opening, May regulate microtubules depolymerization (PubMed:22610367), Binds calcium and has a cytoprotective function (PubMed:24040826)


This is cAMP-dependent protein kinase type I-beta regulatory subunit protein, from Human, contains 381 amino acids, is membrane-bound, locates in Cell membrane.

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells


This is Protein nubbin protein, from Fruit fly, contains 601 amino acids, locates in Nucleus.

DNA-binding regulatory protein implicated in early development, Involved in neuronal cell fate decision, Repressed directly or indirectly by the BX-C homeotic proteins

Belongs to the POU transcription factor family, Class-2 subfamily


This is SWR1-complex protein 3 protein, from Baker's yeast, contains 625 amino acids, locates in Nucleus.

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling, Involved in chromosome stability


This is Histamine H1 receptor protein, from Guinea pig, contains 488 amino acids, is membrane-bound, locates in Cell membrane.


This is Histamine H1 receptor protein, from Rat, contains 486 amino acids, is membrane-bound, locates in Cell membrane.


This is V-type proton ATPase subunit C protein, from Baker's yeast, contains 392 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:10781598, PubMed:11777935, PubMed:1730668, PubMed:8416931), V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8416931), Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (PubMed:15792803), Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section (PubMed:15792803)

Belongs to the V-ATPase C subunit family


This is Sodium- and chloride-dependent GABA transporter 2 protein, from Rat, contains 602 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:1400419, PubMed:22896705), Mediates transport of taurine and is the major taurine transporter in hepatocytes (PubMed:22896705), Can also mediate transport of beta-alanine and hypotaurine (By similarity)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A13 subfamily


This is Sodium- and chloride-dependent GABA transporter 2 protein, from Mouse, contains 602 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:8420981, PubMed:22896705, PubMed:30270321), Can also mediate transport of beta-alanine, taurine and hypotaurine and is the major taurine transporter in hepatocytes (PubMed:8420981, PubMed:22896705, PubMed:30270321)


This is Trehalose-phosphatase protein, from Baker's yeast, contains 896 amino acids, is soluble, locates in Cytoplasm.

Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process

In the C-terminal section; belongs to the trehalose phosphatase family


This is Carcinoembryonic antigen-related cell adhesion molecule 1 protein, from Mouse, contains 521 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 3 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

(Microbial infection) In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein

Belongs to the immunoglobulin superfamily, CEA family


This is Heterogeneous nuclear ribonucleoprotein H3 protein, from Human, contains 346 amino acids, locates in Nucleus.

Involved in the splicing process and participates in early heat shock-induced splicing arrest, Due to their great structural variations the different isoforms may possess different functions in the splicing reaction


This is Solute carrier family 2, facilitated glucose transporter member 3 protein, from Mouse, contains 493 amino acids, is membrane-bound, locates in Cell membrane.

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane, Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate, Does not mediate fructose transport

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily


This is Carnitine O-palmitoyltransferase 1, liver isoform protein, from Rat, contains 773 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:16908527, PubMed:21990363), Plays an important role in hepatic triglyceride metabolism (PubMed:18349115)

Belongs to the carnitine/choline acetyltransferase family


This is C-C chemokine receptor type 1 protein, from Human, contains 355 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for a C-C type chemokine, Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level, Responsible for affecting stem cell proliferation


This is G-protein coupled receptor 183 protein, from Human, contains 361 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity), Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711), Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity), Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity), Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity), Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity), Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878), Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity), Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity), Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity), Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897), Promotes osteoclast precursor migration to bone surfaces (By similarity), Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897), Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity)


This is Dynamin-like GTPase MGM1, mitochondrial protein, from Baker's yeast, contains 881 amino acids, locates in Mitochondrion.

Dynamin-related GTPase required for mitochondrial fusion, Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Delta-type opioid receptor protein, from Mouse, contains 372 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling leads to the inhibition of adenylate cyclase activity, Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, Plays a role in the perception of pain and in opiate-mediated analgesia, Plays a role in developing analgesic tolerance to morphine


This is Pyrroline-5-carboxylate reductase 1, mitochondrial protein, from Human, contains 319 amino acids, locates in Mitochondrion.

Housekeeping enzyme that catalyzes the last step in proline biosynthesis, Can utilize both NAD and NADP, but has higher affinity for NAD, Involved in the cellular response to oxidative stress

Belongs to the pyrroline-5-carboxylate reductase family


This is Elongation factor 2 protein, from Baker's yeast, contains 842 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation (PubMed:16950777, PubMed:29069440, PubMed:14976550, PubMed:17082187), During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively (PubMed:16950777, PubMed:14976550, PubMed:17082187), Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:16950777, PubMed:14976550, PubMed:17082187)

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily


This is Aspartic proteinase 3 protein, from Baker's yeast, contains 569 amino acids, is membrane-bound, locates in Cell membrane.

Cleaves proteins C-terminally to mono- and paired-basic residues, Involved in the shedding of a subset of GPI-anchored plasma membrane proteins from the cell surface, including itself, GAS1 and MSB2, May also play a role in the maturation of GPI-mannoproteins associated with the cell wall, Can process the alpha-mating factor precursor, Required for cell wall integrity


This is V-type proton ATPase subunit d protein, from Baker's yeast, contains 345 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8509410), V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8509410), This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector (PubMed:8509410), Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (PubMed:8509410)

Belongs to the V-ATPase V0D/AC39 subunit family


This is Transcription factor tau 95 kDa subunit protein, from Baker's yeast, contains 649 amino acids, locates in Nucleus.

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements, Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function, Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes, Participates in the interconnection of tauA with tauB via its contacts with TFC3 and TFC6, Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability


This is Phosphatidylinositol-3-phosphatase SAC1 protein, from Baker's yeast, contains 623 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:10625610, PubMed:11792713), Has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:10625610), May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton (PubMed:11514624)


This is Actin-related protein 2 protein, from Baker's yeast, contains 391 amino acids, is soluble, locates in Cytoplasm.

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks, Seems to contact the pointed end of the daughter actin filament (By similarity)

Belongs to the actin family, ARP2 subfamily


This is 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 protein, from Baker's yeast, contains 534 amino acids, is soluble, locates in Cytoplasm.

Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:8406038, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:32576952, PubMed:34154323), DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:8406038, PubMed:24422557, PubMed:27694803, PubMed:31463593, PubMed:34154323), Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (PubMed:31463593)

Belongs to the DPH1/DPH2 family, DPH2 subfamily


This is Protein HIR1 protein, from Baker's yeast, contains 840 amino acids, locates in Nucleus.

Component of the HIR complex, which cooperates with ASF1 to promote replication-independent chromatin assembly, The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B, DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex, The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1


This is Beta-glucan synthesis-associated protein KRE6 protein, from Baker's yeast, contains 720 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in the synthesis of (1->6)- and (1->3)-beta-D-glucan polymers of the yeast cell wall in vivo, It is required for full activity of beta-glucan synthase in vitro, May be involved in the maturation and transport of cell wall proteins (CWP) to the cell wall, May act as a transglucosidase and contribute to the construction of a protein-bound glucan-structure that acts as an acceptor site for the addition of (1->6)-beta-D-glucan at the cell surface


This is H/ACA ribonucleoprotein complex subunit NHP2 protein, from Baker's yeast, contains 156 amino acids, locates in Nucleus.

Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis (PubMed:9843512, PubMed:9848653), This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:9843512, PubMed:9848653), Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (PubMed:9843512, PubMed:9848653), The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs (PubMed:21131909), The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA (PubMed:21131909), Essential for growth (PubMed:9843512), Directly binds H/ACA snoRNAs (PubMed:11433018)

Belongs to the eukaryotic ribosomal protein eL8 family


This is DNA-directed RNA polymerase I subunit RPA12 protein, from Baker's yeast, contains 125 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger, locates in Nucleus.

TFIIS-type

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors, Besides, RNA polymerase I has intrinsic RNA cleavage activity, Proposed to contribute to the polymerase catalytic activity and form the polymerase active center together with the two largest subunits, Subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I, Involved in transcriptional termination

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is V-type proton ATPase subunit a, vacuolar isoform protein, from Baker's yeast, contains 840 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1491220, PubMed:8798414, PubMed:11278748), V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1491220, PubMed:11278748), Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:8798414, PubMed:11278748)

Belongs to the V-ATPase 116 kDa subunit family


This is Mediator of RNA polymerase II transcription subunit 22 protein, from Baker's yeast, contains 121 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 22 family


This is Peroxisomal 2,4-dienoyl-CoA reductase SPS19 [(3E)-enoyl-CoA-producing] protein, from Baker's yeast, contains 292 amino acids, locates in Peroxisome.

Auxiliary enzyme of beta-oxidation, Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome, Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA, Dispensable for growth and sporulation on solid acetate and oleate media, but is essential for these processes to occur on petroselineate

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is ATP-dependent RNA helicase SUV3, mitochondrial protein, from Baker's yeast, contains 737 amino acids, is soluble, locates in Mitochondrion.

Required for intron-independent turnover and processing of mitochondrial RNA, It is a key control element in nuclear-mitochondrial interactions


This is Mediator of RNA polymerase II transcription subunit 18 protein, from Baker's yeast, contains 307 amino acids, locates in Nucleus.

Belongs to the Mediator complex subunit 18 family


This is Heat shock protein homolog SSE1 protein, from Baker's yeast, contains 693 amino acids, is soluble, locates in Cytoplasm.

Has a calcium-dependent calmodulin-binding activity, Required for normal growth at various temperatures

Belongs to the heat shock protein 70 family


This is Vacuolar segregation protein PEP7 protein, from Baker's yeast, contains 515 amino acids, has 1 C2H2-type Zinc finger, has 1 FYVE-type 1; atypical Zinc finger, has 1 FYVE-type Zinc finger, is membrane-bound, locates in Lysosome/Vacuole.

FYVE-type 1; atypical

FYVE-type

Required for vacuole segregation and vacuole protein sorting, Possibly part of a complex which tethers the vacuole membrane to microtubules, either directly or via kinesin or dynein-like motor proteins, Probably functions in several interorganelle traffic pathways


This is Fumarate reductase 1 protein, from Baker's yeast, contains 470 amino acids, is soluble, locates in Cytoplasm.

Irreversibly catalyzes the reduction of fumarate to succinate, Together with the second isozyme of soluble fumarate reductase (OSM1), essential for anaerobic growth, Involved in maintaining redox balance, Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2)

Belongs to the FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily


This is Trans-aconitate 3-methyltransferase protein, from Baker's yeast, contains 299 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate and 3-isopropylmalate at high affinity and of other molecules like cis-aconitate, isocitrate, and citrate at lower velocities and affinities, The function of trans-aconitate methylation appears to be in reducing the toxicity of this spontaneous breakdown product of cis-aconitate, The role of 3-isopropylmalate methylation is unclear but may represent a metabolic branch at 3-isopropylmalate, where some of the material is taken in the pathway leading to leucine and some is taken in a pathway to the 3-isopropylmalate methyl ester, a molecule that provides a signal to switch from vegetative to invasive growth in response to amino acid starvation

Belongs to the methyltransferase superfamily, Tam family


This is Elongation factor 1 alpha-like protein protein, from Baker's yeast, contains 611 amino acids, is soluble, locates in Cytoplasm.

GTPase component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:16554824, PubMed:20947765, PubMed:21102444), The Dom34-Hbs1 complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:16554824, PubMed:20947765), Following ribosome-binding, the Pelota-HBS1L complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:16554824, PubMed:20947765), The Dom34-Hbs1 complex is also involved in non-functional rRNA decay (PubMed:21102444)

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family


This is mRNA cap guanine-N7 methyltransferase protein, from Baker's yeast, contains 436 amino acids, locates in Nucleus.

Responsible for methylating the 5'-cap structure of mRNAs

Belongs to the class I-like SAM-binding methyltransferase superfamily, mRNA cap 0 methyltransferase family


This is Glycerol-3-phosphate O-acyltransferase 1 protein, from Baker's yeast, contains 759 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Dual substrate-specific glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase, catalyzing the first and committed reaction in the de novo synthesis of glycerophospholipids and triacylglycerols (TAGs), Prefers Gly-3-P over dihydroxyacetone phosphate and has a marked preference for 16-carbon fatty acyl chains, Transfers a fatty acid from fatty acyl-CoA to the sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid (LysoPA), These lipids not only are precursors of glycerolipids, but also are dynamic components of signal transduction systems that control cell physiology (PubMed:11544256), SCT1 is the primary supplier of diacylglycerols (DAG), used mainly in TAG synthesis and phosphatidylcholine (PC) synthesis through the CDP-choline pathway (PubMed:12167660), Regulates fatty acid desaturation, that is, the ratio of unsaturated versus saturated fatty acyl chains, by competing with the desaturase OLE1 for the common substrate C16:0-CoA, Sequesters C16:0-CoA into lipids, thereby shielding it from desaturation by OLE1 (PubMed:22323296)


This is Ferric/cupric reductase transmembrane component 1 protein, from Baker's yeast, contains 686 amino acids, is membrane-bound, locates in Cell membrane.

Metalloreductase responsible for reducing extracellular iron and copper prior to import, Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores, Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane, Also participates in Cu(2+) reduction and Cu(+) uptake

Belongs to the ferric reductase (FRE) family


This is Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1 protein, from Baker's yeast, contains 747 amino acids, is membrane-bound, locates in Mitochondrion.

Catalytic subunit of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover, The protease is probably ATP-dependent, Important to maintain the integrity of the mitochondrial compartment, Required both for the degradation of unassembled subunit 2 of cytochrome c oxidase (COX2) and for efficient assembly of mitochondrial respiratory chain, Binds unfolded substrates in an ATPase-independent manner; binding of folded COX2, a physiological substrate, requires an active ATPase but when COX2 is destabilized an active ATPase is no longer necessary

In the C-terminal section; belongs to the peptidase M41 family


This is ATP-dependent DNA helicase II subunit 1 protein, from Baker's yeast, contains 602 amino acids, locates in Nucleus.

Single-stranded DNA-dependent ATP-dependent helicase, Involved in non-homologous end joining (NHEJ) DNA double strand break repair, DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA, Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection, Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation, Required also for telomere recombination to repair telomeric ends in the absence of telomerase, KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase, Involved in telomere maintenance, Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement, Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere, Required for mating-type switching


This is E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 protein, from Baker's yeast, contains 619 amino acids, locates in Nucleus.

Component of the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 that mediates ubiquitination and subsequent desumoylation of sumoylated proteins and proteins containing SUMO-like domains for their degradation (PubMed:11139495, PubMed:16325482, PubMed:18032921, PubMed:17669696, PubMed:17848550, PubMed:18499666, PubMed:18948542, PubMed:31015336), The STUbL complex SLX5/SLX8 stimulates ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2, and mediates the proteolytic down-regulation of sumoylated proteins (PubMed:18032921), The STUbL complex SLX5/SLX8 is involved in ubiquitin-mediated degradation of histone variant CSE4, preventing mislocalization to euchromatin (PubMed:26960795), The complex plays an essential role in maintenance of chromosome stability and links SUMO-dependent ubiquitination to a centromere-specific function during mitosis (PubMed:23785440), The complex is involved in proteolysis of spindle positioning protein KAR9 and ensures correct spindle function by regulating levels of microtubule-associated proteins (PubMed:26906737), During replication, the complex helps prevent DNA lesions via recombination and has a role in localizing the DNA damage protein DCD2 (PubMed:16325482, PubMed:17591698), The complex especially ubiquitinates the nuclease YEN1 and prevents persistent accumulation of a fraction of YEN1 associated with sites of activity in late G2/M and helps maintain the balance between pro- and anti-crossover pathways during homologous recombination (PubMed:30479332), It is also involved in ubiquitin-mediated degradation of DNA repair proteins RAD52 and RAD57 (PubMed:18032921), Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci (PubMed:18086879), Finally, the complex is recruited to distinct genomic hotspots of non-H2B protein ubiquitination (ub-hotspots) by the sumoylated transcription factor-like protein EUC1 where it ubiquitinates EUC1 and presumably other targets (PubMed:31015336)


This is Mitochondrial import inner membrane translocase subunit TIM12 protein, from Baker's yeast, contains 109 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force, In the TIM22 complex, it acts as a docking point for the soluble TIM9-TIM10 heterohexamer that guides the target proteins in transit through the aqueous mitochondrial intermembrane space


This is Chromatin structure-remodeling complex subunit RSC7 protein, from Baker's yeast, contains 435 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, Together with HTL1, LDB7, RSC3, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity, Acidic protein important for nuclear protein localization

Belongs to the RSC7/SWP82 family, RSC7 subfamily


This is D-lactate dehydrogenase [cytochrome] 1, mitochondrial protein, from Baker's yeast, contains 587 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the stereospecific oxidation of D-lactate to pyruvate

Belongs to the FAD-binding oxidoreductase/transferase type 4 family


This is ATP-dependent RNA helicase DRS1 protein, from Baker's yeast, contains 752 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in ribosome assembly

Belongs to the DEAD box helicase family, DDX27/DRS1 subfamily


This is Ribose-phosphate pyrophosphokinase 1 protein, from Baker's yeast, contains 427 amino acids, is soluble, locates in Cytoplasm.

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis, Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Belongs to the ribose-phosphate pyrophosphokinase family


This is Mitochondrial import inner membrane translocase subunit TIM23 protein, from Baker's yeast, contains 222 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane


This is Presequence protease, mitochondrial protein, from Baker's yeast, contains 989 amino acids, is soluble, locates in Mitochondrion.

Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (PubMed:15772085, PubMed:25176146), Preferentially cleaves the N-terminal side of paired basic amino acid residues (PubMed:35997162), Also degrades other unstructured peptides (PubMed:25176146), May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (PubMed:35997162)

Belongs to the peptidase M16 family, PreP subfamily


This is U3 small nucleolar ribonucleoprotein protein IMP3 protein, from Baker's yeast, contains 183 amino acids, locates in Nucleus.

Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing

Belongs to the universal ribosomal protein uS4 family


This is Transcription elongation factor SPT4 protein, from Baker's yeast, contains 102 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing, The complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene, Structural and functional component of the centromeric and heterochromatic loci linking chromatin structure with kinetochore function and gene silencing


This is Ribosome assembly factor MRT4 protein, from Baker's yeast, contains 236 amino acids, locates in Cytoplasm.

Component of the ribosome assembly machinery, Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes

Belongs to the universal ribosomal protein uL10 family


This is Cleavage stimulation factor subunit 2 protein, from Human, contains 577 amino acids, locates in Nucleus.

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs, This subunit is directly involved in the binding to pre-mRNAs (By similarity)


This is Ubiquitin-conjugating enzyme E2 6 protein, from Baker's yeast, contains 250 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the covalent attachment of ubiquitin to other proteins, Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system, Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains

Belongs to the ubiquitin-conjugating enzyme family


This is Mediator of RNA polymerase II transcription subunit 9 protein, from Baker's yeast, contains 149 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 9 family


This is Protein DOM34 protein, from Baker's yeast, contains 386 amino acids, is soluble, locates in Cytoplasm.

Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:16554824, PubMed:17889667, PubMed:18180287, PubMed:19420139, PubMed:20947765, PubMed:21102444), In the Dom34-Hbs1 complex, DOM34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (PubMed:16554824, PubMed:20947765), Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (PubMed:20947765), The Dom34-Hbs1 complex is also involved in non-functional rRNA decay (PubMed:21102444)

Belongs to the eukaryotic release factor 1 family, Pelota subfamily


This is ATP-dependent permease MDL1, mitochondrial protein, from Baker's yeast, contains 695 amino acids, is membrane-bound, locates in Mitochondrion.

Mediates export of peptides with molecular masses of 2100 to 600 daltons generated upon proteolysis of mitochondrial inner membrane proteins

Belongs to the ABC transporter superfamily, ABCB family, Mitochondrial peptide exporter (TC 3,A,1,212) subfamily


This is La protein homolog protein, from Baker's yeast, contains 275 amino acids, locates in Nucleus.

Molecular chaperone that binds nascent RNA polymerase III transcripts, stabilizing these RNAs against exonucleases, Required for the 3' endonucleolytic cleavage that matures tRNA precursors and for efficient folding of certain pre-tRNAs, Cooperates with GCD14 in the maturation of a subset of RNA polymerase III transcripts, Functions also in the assembly of certain RNA polymerase II-transcribed RNAs into RNPs, Binds and stabilizes newly synthesized U6 snRNA as well as precursors of U3 snRNA from degradation, Facilitates efficient Sm protein binding, thus assisting formation of the U4/U6 snRNP, Required for Ty3 normal transposition frequency


This is Phosphoglucomutase 1 protein, from Baker's yeast, contains 570 amino acids, is soluble, locates in Cytoplasm.

Minor phosphoglucomutase isozyme that catalyzes the interconversion of glucose 1-phosphate and glucose 6-phosphate (PubMed:5784209), Constitutes about 10-20% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755), Key enzyme in hexose metabolism, The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate, The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884)

Belongs to the phosphohexose mutase family


This is Heat shock protein 78, mitochondrial protein, from Baker's yeast, contains 811 amino acids, is soluble, locates in Mitochondrion.

Required, in concert with mitochondrial Hsp70 (SSC1), for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress, May extract proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system, Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress, Its main role may be maintaining the molecular chaperone SSC1 in a soluble and functional state, Also required for the efficient degradation of proteins by matrix protease PIM1, independent on its protein remodeling activity


This is Protein NIP100 protein, from Baker's yeast, contains 868 amino acids, is soluble, locates in Cytoplasm.

Motor-binding component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding (By similarity), The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint


This is THO complex subunit MFT1 protein, from Baker's yeast, contains 392 amino acids, locates in Nucleus.

Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export, The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription, THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase, It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA


This is Delta-type opioid receptor protein, from Rat, contains 372 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling leads to the inhibition of adenylate cyclase activity, Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, Plays a role in the perception of pain and in opiate-mediated analgesia, Plays a role in developing analgesic tolerance to morphine

Belongs to the G-protein coupled receptor 1 family


This is Kappa-type opioid receptor protein, from Mouse, contains 380 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins, Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling leads to the inhibition of adenylate cyclase activity, Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, Plays a role in the perception of pain, Plays a role in mediating reduced physical activity upon treatment with synthetic opioids, Plays a role in the regulation of salivation in response to synthetic opioids, May play a role in arousal and regulation of autonomic and neuroendocrine functions


This is Flavin prenyltransferase PAD1, mitochondrial protein, from Baker's yeast, contains 242 amino acids, locates in Mitochondrion.

Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1/ubiD (PubMed:25647642), The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN (By similarity), Involved in the decarboxylation of phenylacrylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives which play the role of aroma metabolites, Also involved in the degradation of the food preservative sorbic acid (2,4-hexadienoic acid) to a volatile hydrocarbon, 1,3-pentadiene, Not essential for ubiquinone synthesis (PubMed:17889824, PubMed:20471595), Can rescue Q biosynthesis in E,coli strains lacking UbiX (PubMed:17889824), Has mRNA binding activity (PubMed:20844764)


This is Translocation protein SEC66 protein, from Baker's yeast, contains 206 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex, A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon, SEC66 is required to attach or retain SEC72 in the SEC63 complex, It is essential for growth at elevated temperatures


This is Protein S100-A3 protein, from Human, contains 101 amino acids, is soluble, locates in Cytoplasm.

Binds both calcium and zinc, May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation


This is fMet-Leu-Phe receptor protein, from Mouse, contains 364 amino acids, is membrane-bound, locates in Cell membrane.

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors, Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release, This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system, Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity), Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (By similarity)


This is Ecdysone receptor protein, from Fruit fly, contains 878 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Receptor for ecdysone (PubMed:1913820, PubMed:30293839), Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes (PubMed:1913820, PubMed:30293839)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Mediator of RNA polymerase II transcription subunit 20 protein, from Baker's yeast, contains 210 amino acids, locates in Nucleus.

Belongs to the Mediator complex subunit 20 family


This is RNA-binding protein PIN4 protein, from Baker's yeast, contains 668 amino acids, is soluble, locates in Cytoplasm.

Involved in normal G2/M phase transition of the mitotic cell cycle, In association with RAD53, also involved in checkpoint control in response to DNA damage


This is Histone acetyltransferase SAS3 protein, from Baker's yeast, contains 831 amino acids, has 1 C2HC MYST-type Zinc finger, locates in Nucleus.

C2HC MYST-type

Catalytic component of the histone acetyltransferase NuA3 complex, that acetylates Lys-14 of histone H3, Recruitment of NuA3 to nucleosomes requires methylated histone H3, In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation, In vitro, SAS3 acetylates free histones H3 and H4, It is involved in silencing the HMR locus


This is Peroxiredoxin PRX1, mitochondrial protein, from Baker's yeast, contains 261 amino acids, locates in Mitochondrion.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events, Involved in mitochondrial protection of cadmium-induced oxidative stress

Belongs to the peroxiredoxin family, Prx6 subfamily


This is Transcriptional regulatory protein ASH1 protein, from Baker's yeast, contains 588 amino acids, has 1 GATA-type; atypical Zinc finger, locates in Nucleus.

GATA-type; atypical

Component of the RPD3C(L) histone deacetylase complex (HDAC), Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, ASH1 is necessary to repress HO in daughter cells to block mating-type switching through its binding to HO promoter 5'-YTGAT-3' sites, Also involved in pseudohyphal growth


This is U3 small nucleolar RNA-associated protein 11 protein, from Baker's yeast, contains 250 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA


This is Serine/threonine-protein kinase tousled-like 1 protein, from Caenorhabditis elegans, contains 965 amino acids, locates in Nucleus.

Essential for appropriate transcription during embryonic development, May act during transcription elongation to activate the RNA polymerase II large subunit (ama-1) by phosphorylating the Ser-2 residues of the C-terminal domain 7-residue repeats, Does not phosphorylate histone H3

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Homeobox protein engrailed-like ceh-16 protein, from Caenorhabditis elegans, contains 187 amino acids, locates in Nucleus.

Transcriptional regulator which binds to DNA to regulate gene expression and promote seam cell development and differentiation during embryogenesis (PubMed:15659483, PubMed:19607822), Plays a role in maintaining the boundaries between the lateral rows of seam cells and the ventral and dorsal row of epidermal cells during embryonic development (PubMed:15659483), Negatively regulates the expression of the fusion effector protein eff-1 to prevent seam cell fusion with the dorsal and ventral epidermal cells during embryonic elongation (PubMed:15659483), Positively regulates seam cell self-renewal and expansion during the L2 larval stage to promote seam cell development (PubMed:19607822), This role does not seem to be via regulation of eff-1 expression (PubMed:19607822), Specifically, it is required for the asymmetric division of the V5,p seam cell during the L2 larval stage, and in turn the asymmetric nuclear distribution of pop-1 in V5,p daughter cells (PubMed:19607822)

Belongs to the engrailed homeobox family


This is Condensin-2 complex subunit kle-2 protein, from Caenorhabditis elegans, contains 821 amino acids, locates in Nucleus.

Regulatory subunit of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation and in chromosome segregation in mitosis and in meiosis

Belongs to the CND2 H2 (condensin-2 subunit 2) family


This is Inositol polyphosphate 5-phosphatase protein, from Caenorhabditis elegans, contains 398 amino acids, is soluble, locates in Cytoplasm.

Dephosphorylates a number of phosphatidylinositols, Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, Has a role in sperm activation and motility, Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2

Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family


This is E3 ubiquitin-protein ligase bre-1 protein, from Caenorhabditis elegans, contains 837 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B (By similarity), H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (By similarity), Involved in regulating stem cell proliferative fate (PubMed:25564623)


This is Regulator of microtubule dynamics protein 1 protein, from Caenorhabditis elegans, contains 226 amino acids, is soluble, locates in Cytoplasm.

Acts in chromosome segregation and organization during mitosis


This is Sop-2-related protein 1 protein, from Caenorhabditis elegans, contains 1000 amino acids, locates in Nucleus.

Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development, Not required to initiate repression, but to maintain it during later stages of development, Also required to repress expression of other genes, Binds RNA in a sequence-independent manner


This is Homeobox protein pal-1 protein, from Caenorhabditis elegans, contains 270 amino acids, locates in Nucleus.

Transcriptional activator, Interacts with promoter regions for tbx-8,9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes, Binds the sequence ATTTATGAC, Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development, Activates the gene for mab-5 in embryo development, Necessary for vab-7 expression in C blastomeres in the posterior of embryos, Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development, Binds to ced-3 promoter and activated expression which is crucial for tail-spike cell death, Has a role in E cell specification in endoderm development and body wall muscle development


This is Peptidyl-prolyl cis-trans isomerase CYP20-3, chloroplastic protein, from Mouse-ear cress, contains 260 amino acids, is soluble, locates in Plastid.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Required for the light-induced increase of thiol accumulation, Assists the folding or assembly of SAT1 enzyme to form the cysteine synthase complex, Links light and redox signals to the regulation of cysteine biosynthesis in response to stress

Belongs to the cyclophilin-type PPIase family


This is Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic protein, from Mouse-ear cress, contains 371 amino acids, locates in Plastid.

Heterodimeric geranyl(geranyl)-diphosphate (GPP) synthase large subunit, In vitro, the large subunit catalyzes mainly the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate while the small subunit alone is inactive, Upon association of the two subunits, the product profile changes and the production of gerany-diphosphate is strongly increased


This is Meiotic spindle formation protein mei-1 protein, from Caenorhabditis elegans, contains 472 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner (PubMed:28783150), Microtubule severing may promote rapid reorganization of cellular microtubule arrays, Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles (PubMed:8027178, PubMed:10809666, PubMed:12885567, PubMed:19087961, PubMed:23918937), In body wall muscles, regulates organization of myosin thick filaments (PubMed:22621901)

Belongs to the AAA ATPase family, Katanin p60 subunit A1 subfamily


This is Degenerin mec-10 protein, from Caenorhabditis elegans, contains 724 amino acids, is membrane-bound, locates in Cell membrane.

Subunit of an amiloride-sensitive cation channel (degenerin channel complex) permeable for sodium, potassium, lithium and N-methylglucamine, and required for mechanosensory transduction (touch sensitivity) (PubMed:11875573, PubMed:17261841, PubMed:7509039, PubMed:12478294), Negatively regulates the turning step of male mating behavior (PubMed:17611271)

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family


This is Kappa-type opioid receptor protein, from Rat, contains 380 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins, Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling leads to the inhibition of adenylate cyclase activity, Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance, Plays a role in the perception of pain, Plays a role in mediating reduced physical activity upon treatment with synthetic opioids, Plays a role in the regulation of salivation in response to synthetic opioids, May play a role in arousal and regulation of autonomic and neuroendocrine functions


This is Ubiquitin carboxyl-terminal hydrolase 4 protein, from Mouse, contains 962 amino acids, locates in Cytoplasm.

Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins, Deubiquitinates PDPK1, Deubiquitinates TRIM21, Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface, Deubiquitinates HAS2, May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3, This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6,U5 snRNP, May also play a role in the regulation of quality control in the ER

Belongs to the peptidase C19 family, USP4 subfamily


This is Protein transport protein SSS1 protein, from Baker's yeast, contains 80 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Part of the Sec61 complex, which is the major component of channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER), The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER, In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor, The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit, SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2, Also part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein ER import


This is Dehydrodolichyl diphosphate synthase complex subunit RER2 protein, from Baker's yeast, contains 286 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery, Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER)


This is Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2 protein, from Baker's yeast, contains 410 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for calcium regulation, May regulate calcium accumulation by a non-vacuole organelle, Also regulates the activity of CSH1 and SUR1 during mannosyl phosphorylinositol ceramide synthesis


This is Polycomb group RING finger protein 2 protein, from Human, contains 344 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Transcriptional repressor, Binds specifically to the DNA sequence 5'-GACTNGACT-3', Has tumor suppressor activity, May play a role in control of cell proliferation and/or neural cell development, Regulates proliferation of early T progenitor cells by maintaining expression of HES1, Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity), Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332)


This is Tyrosine-protein phosphatase non-receptor type 7 protein, from Human, contains 360 amino acids, is soluble, locates in Cytoplasm.

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1, Plays a role in the regulation of T and B-lymphocyte development and signal transduction

Belongs to the protein-tyrosine phosphatase family, Non-receptor class subfamily


This is Serpin B6 protein, from Human, contains 376 amino acids, is soluble, locates in Cytoplasm.

May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity), Inhibitor of cathepsin G, kallikrein-8 and thrombin, May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss

Belongs to the serpin family, Ov-serpin subfamily


This is Histamine H1 receptor protein, from Human, contains 487 amino acids, is membrane-bound, locates in Cell membrane.

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system


This is Type-2 angiotensin II receptor protein, from Mouse, contains 363 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8726696), Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (By similarity), Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15539617)


This is Nuclear receptor ROR-alpha protein, from Human, contains 523 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence, Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism, Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively, Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts, Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1, Required for proper cerebellum development (PubMed:29656859), Regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction, Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression, Therefore influences the period length and stability of the clock, Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG, In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1, Induces a rhythmic expression of some of these genes, In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism, Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1, In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms, May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding, Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus, Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A, May inhibit cell growth in response to cellular stress, May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling


This is 5-hydroxytryptamine receptor 1B protein, from North American opossum, contains 388 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling inhibits adenylate cyclase activity, Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways, Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior, Besides, plays a role in vasoconstriction of cerebral arteries


This is D(3) dopamine receptor protein, from Human, contains 400 amino acids, is membrane-bound, locates in Cell membrane.

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase, Promotes cell proliferation


This is Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial protein, from Mouse, contains 390 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle


This is rRNA 2'-O-methyltransferase fibrillarin protein, from Fission yeast, contains 305 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins, Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA, Site specificity is provided by a guide RNA that base pairs with the substrate, Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA, Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity)

Belongs to the methyltransferase superfamily, Fibrillarin family


This is Hepatocyte nuclear factor 3-alpha protein, from Mouse, contains 468 amino acids, locates in Nucleus.

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs, Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles, Plays a role in prostate morphogenesis and epithelial cell differentiation, FOXA1 and FOXA2 are essential for hepatic specification, FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung, FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding of glucocorticoid receptor/NR3C1 to the IL6 promoter, FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons, Modulates the transcriptional activity of nuclear hormone receptors, Is involved in ESR1-mediated transcription, Inhibits NKX2-1-mediated transcription from the SFTPC promoter in lung epithel independently from DNA-binding, Involved in regulation of apoptosis, Involved in cell cycle regulation, Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc, Interacts with the cis-acting regulatory regions of these genes, Involved in glucose homeostasis; activates the GCG promoter


This is Hepatocyte nuclear factor 3-beta protein, from Mouse, contains 459 amino acids, locates in Cytoplasm.

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), In embryonic development is required for notochord formation, Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; Foxa1 and Foxa2 seem to have at least in part redundant roles, FOXA1 and FOXA2 are essential for hepatic specification, FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung, FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding glucocorticoid receptor/NR3C1 to the IL6 promoter, FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons, Modulates the transcriptional activity of nuclear hormone receptors; inhibits AR-mediated transcription from the LCN5 promoter, Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation, Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc, Interacts with the cis-acting regulatory regions of these genes, Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis, In pancreatic beta cells activates transcription of potassium channel subunits KCNJ11 and ABCC8, Involved in regulation of fat metabolism; activates transcriptional programs of lipid metabolism and ketogenesis at low insulin state, Involved in transcriptional regulation of MUC2 in the intestine


This is Alpha-actinin-2 protein, from Human, contains 894 amino acids, is soluble, locates in Cytoplasm.

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures, This is a bundling protein


This is Sterol O-acyltransferase 1 protein, from Human, contains 550 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:9020103, PubMed:32433614, PubMed:32433613, PubMed:32944968), Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103), Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614)

Belongs to the membrane-bound acyltransferase family, Sterol o-acyltransferase subfamily


This is RNA-binding protein FUS protein, from Human, contains 526 amino acids, has 1 RanBP2-type Zinc finger, locates in Nucleus.

DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383), Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092), Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307), Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410), In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity)


This is Protein DEK protein, from Human, contains 375 amino acids, locates in Nucleus.


This is Transcription factor SOX-6 protein, from Human, contains 828 amino acids, locates in Nucleus.

Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable), Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate, Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes, Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts, Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube, Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity)


This is Transcription factor SOX-11 protein, from Human, contains 441 amino acids, locates in Nucleus.

Transcription factor that acts as a transcriptional activator (PubMed:24886874, PubMed:26543203), Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity), Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron (By similarity), Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity)


This is Protein MPE1 protein, from Baker's yeast, contains 441 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB


This is RNA polymerase II degradation factor 1 protein, from Baker's yeast, contains 738 amino acids, locates in Nucleus.

Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II (PubMed:11859374, PubMed:15166235, PubMed:15960978), Also involved in telomere length regulation (PubMed:15863512), Binds DNA (PubMed:15863512)


This is Bromodomain-containing factor 1 protein, from Baker's yeast, contains 686 amino acids, locates in Nucleus.

Transcription factor involved in the expression of a broad class of genes including snRNAs, Required for sporulation and DNA-damage repair, Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation


This is Oxysterol-binding protein homolog 4 protein, from Baker's yeast, contains 434 amino acids, is membrane-bound, locates in Golgi apparatus.

Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes, Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol, Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:20008566, PubMed:15173322, PubMed:16136145, PubMed:22162133), Involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum, Specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation, Thus, by maintaining a PI4P gradient at the ER/Golgi interface, SAC1 may drive PS transport (PubMed:25849868, PubMed:16136145, PubMed:22162133), Displays a similar affinity for PI4P and sterols (PubMed:22162133), Binds sterol and PI4P in a mutually exclusive manner (PubMed:22162133), Involved in ergosterol transport from the plasma membrane (PM) to the ER (PubMed:16585271), Mediates sterol transport from the ER to mitochondria (PubMed:29487131), Involved in the negative regulation of Golgi-derived transport vesicle biogenesis (PubMed:8978672), Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos (PubMed:24213531)


This is Poly [ADP-ribose] polymerase protein, from Fruit fly, contains 994 amino acids, has 2 PARP-type Zinc finger, locates in Nucleus.

PARP-type

PARP-type

Plays a fundamental role in organizing chromatin on a global scale (PubMed:12183365), Autoregulates Parp transcription by influencing the chromatin structure of its heterochromatic environment (PubMed:12183365)


This is Keratin, type I cytoskeletal 20 protein, from Human, contains 424 amino acids, is soluble, locates in Cytoplasm.

Plays a significant role in maintaining keratin filament organization in intestinal epithelia, When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)

Belongs to the intermediate filament family