This is Mitochondrial import receptor subunit TOM20-2 protein, from Mouse-ear cress, contains 210 amino acids, is membrane-bound, locates in Mitochondrion.

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins, Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore


This is Small ribosomal subunit protein uS11m protein, from Human, contains 194 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS11 family


This is Small ribosomal subunit protein mS34 protein, from Human, contains 218 amino acids, locates in Mitochondrion.

Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation

Belongs to the mitochondrion-specific ribosomal protein mS34 family


This is Tryptophan-containing weak neurotoxin protein, from Monocled cobra, contains 86 amino acids, is soluble, locates in Extracellular.

Neurotoxin that irreversibly inhibits nicotinic acetylcholine receptors (nAChR) and allosterically interacts with muscarinic acetylcholine receptors (mAChR) (PubMed:11279130, PubMed:19682302), The loop II is involved in the interaction of this toxin with nAChR and mAChR (PubMed:27343701, PubMed:26242733), On nAChR, it acts as a competitive antagonist (muscle-type and alpha-7/CHRNA7) with IC(50) values in the micromolar range (PubMed:11279130, PubMed:27343701), On mAChR, in presence of ACh, it partially inhibits the effect of acetylcholine (ACh) (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist) (PubMed:19682302), It also shows a very weak inhibition of GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1 and GABRB3 and GABRG2) subunits (10 uM inhibit 31% current) (PubMed:26221036), In vivo, is nonlethal to mice at concentrations up to 20 mg/kg, but exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats (PubMed:15581687, PubMed:17371532)

Belongs to the snake three-finger toxin family, Ancestral subfamily, Orphan group II sub-subfamily


This is Kininogen-2 protein, from Oriental fire-bellied toad, contains 161 amino acids, is soluble, locates in Extracellular.

Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle, May target bradykinin receptors (BDKRB)

Belongs to the bradykinin-related peptide family


This is Maximins 1/H1 protein, from Giant fire-bellied toad, contains 144 amino acids, is soluble, locates in Extracellular.

antibacterial peptide with activity against both Gram-positive and Gram-negative bacteria, Also shows antimicrobial activity against the fungus C,albicans, In addition, shows strong hemolytic activity


This is Serine protease HTRA3 protein, from Human, contains 453 amino acids, is soluble, locates in Extracellular.

Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1, Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity), May act as a tumor suppressor, Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo, May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724)


This is Serine beta-lactamase-like protein LACTB, mitochondrial protein, from Human, contains 547 amino acids, locates in Mitochondrion.

Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758), Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758), It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758), Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758)


This is Omega-oxotoxin-Ot1a protein, from Lynx spider, contains 123 amino acids, is soluble, locates in Extracellular.

Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2) (By similarity), Is both paralytic and lethal when injected into lepidopteran larvae, Is not toxic to mice

Belongs to the spiderine family, Spiderine subfamily


This is Neurotoxin Oh9-1 protein, from King cobra, contains 57 amino acids, is soluble, locates in Extracellular.

This toxin binds and inhibits rat muscle adult alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE (IC(50)=3,1 uM) and fetal alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND (IC(50)=5,6 uM) nicotinic acetylcholine receptors (nAChR) (PubMed:26448325), It shows a very low inhibition on rat neuronal alpha-3-beta-2/CHRNA3-CHRNB2 nAChR (IC(50)=50,2 uM) nAChR (PubMed:26448325), It does not inhibit human glycine receptor (homopentamer composed of alpha-1 subunits), but seems to potentiate it (about 2-fold increased activity), It binds to the acetylcholine-binding pocket and acts as a competitive antagonist (PubMed:26448325)

Belongs to the snake three-finger toxin family, Short-chain subfamily


This is Huwentoxin-IV protein, from Chinese bird spider, contains 89 amino acids, is soluble, locates in Extracellular.

This lethal neurotoxin (without cyclization at position 53) inhibits neuronal voltage-gated sodium channel Nav1,2/SCN2A (IC(50)=10-150 nM), rNav1,3/SCN3A (IC(50)=338 nM), Nav1,6/SCN8A (IC(50)=117 nM), and hNav1,7/SCN9A (IC(50)=9,6-33 nM) (PubMed:18628201, PubMed:20855463, PubMed:25658507, PubMed:29703751, PubMed:31234412, PubMed:23760503), It inhibits activation of sodium channel by trapping the voltage sensor of domain II (DIIS4) in the closed configuration (PubMed:18628201, PubMed:23760503), The toxin neither shifts the Nav1,7/SCN9A activation curve nor modifies the slope factor (PubMed:20855463), It does not slow fast-inactivation of hNav1,7/SCN9A channels (PubMed:20855463), In addition, it has only a weak affinity for lipid membranes (PubMed:18054060, PubMed:29703751, PubMed:28115115), This toxin also exists with a pyroglutamate at position 53 (PubMed:23826086), The sole difference observed between modified (mHwTx-IV) and unmodified toxins is that moderate or high depolarization voltages (200 mV) permit the unmodified toxin to dissociate, whereas mHwTx-IV toxin does not dissociate, even at high depolarization voltages (PubMed:23826086), These data indicate that mHwTx-IV strongly binds to voltage sensor of sodium channel even at extreme depolarization voltages (PubMed:23826086)

Belongs to the neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily


This is U7 snRNA-associated Sm-like protein LSm11 protein, from Human, contains 360 amino acids, locates in Nucleus.

Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297), Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750), Required for cell cycle progression from G1 to S phases (By similarity), Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750)


This is Venom prothrombin activator hopsarin-D protein, from Stephens' banded snake, contains 455 amino acids, is soluble, locates in Extracellular.

Snake prothrombin activator that attacks the hemostatic system of prey, This protein is functionally similar to blood coagulation factor Xa, The procoagulant activity of hopsarin-D is approximately 10-fold lower than that of trocarin-D and FXa

Belongs to the peptidase S1 family, Snake venom subfamily


This is Cecropin protein, from Savannah tsetse fly, contains 63 amino acids, is soluble, locates in Extracellular.

Cecropins have lytic and antibacterial activity against several Gram-negative bacteria


This is Conserved oligomeric Golgi complex subunit 7 protein, from Human, contains 770 amino acids, is membrane-bound, locates in Golgi apparatus.


This is ATP synthase subunit beta-2, mitochondrial protein, from Mouse-ear cress, contains 556 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain, F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk, During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation, Subunits alpha and beta form the catalytic core in F(1), Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits

Belongs to the ATPase alpha/beta chains family


This is Beta-hexatoxin-Mg1a protein, from Japanese funnel web spider, contains 79 amino acids, is soluble, locates in Extracellular.

Insect and vertebrate active toxin, Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1,2a/SCN2A channel to more hyperpolarized voltages, whereas the insect channel, DmNav1 (para), is not affected, Competes for binding at site 3 of the insect sodium channel, Causes temporary paralysis when injected into lepidopteran larvae at 8,6 nmol/g, A low intracranial injection dose into mice causes lacrimation, closure of the eyes and sweating, A high injection dose causes extensive lacrimation and death

Belongs to the neurotoxin 15 family, 01 (magi-5) subfamily


This is Toxin Lqh4 protein, from Deathstalker scorpion, contains 65 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission (By similarity), Intracerebroventricular injection into mice induces immediate convulsions and urination followed by death, Is toxic to insects and mice

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily


This is Ervatamin-C protein, from Crepe jasmine, contains 208 amino acids, is soluble, locates in Extracellular.

Cysteine proteinase (PubMed:9836431), Hydrolyzes denatured natural substrates such as casein, hemoglobin, azoalbumin and azocasein with a high specific activity (PubMed:9836431), Has little or no activity against synthetic substrates (PubMed:9836431)


This is Apolipoprotein A-II protein, from Horse, contains 76 amino acids, is soluble, locates in Extracellular.

May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism


This is Hexokinase-2 protein, from Yeast, contains 484 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively), Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate


This is Daisho2 protein, from Fruit fly, contains 46 amino acids, is soluble, locates in Extracellular.

Peptide which plays a role in the humoral immune response to a subset of filamentous fungi, including F,oxysporum and F,verticillioides


This is PHD finger-like domain-containing protein 5A protein, from Rat, contains 110 amino acids, locates in Nucleus.

Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency, Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells, Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes, Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes, Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies, Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation (By similarity), Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA, Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (By similarity), Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha (PubMed:12810571)


This is Thioredoxin-like protein 4A protein, from Human, contains 142 amino acids, locates in Nucleus.

Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)


This is Tubulin gamma-1 chain protein, from Mouse, contains 451 amino acids, is soluble, locates in Cytoplasm.

Tubulin is the major constituent of microtubules, The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)


This is Chromobox protein homolog 1 protein, from Human, contains 185 amino acids, locates in Nucleus.

Component of heterochromatin, Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression, Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane


This is Complexin-2 protein, from Mouse, contains 134 amino acids, is soluble, locates in Cytoplasm.

Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons, Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:11163241, PubMed:23345244), Also involved in mast cell exocytosis (PubMed:11163241), Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain (PubMed:12915444)

Belongs to the complexin/synaphin family


This is Cationic peroxidase SPC4 protein, from Sorghum, contains 362 amino acids, is soluble, locates in Extracellular.

Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress, These functions might be dependent on each isozyme/isoform in each plant tissue (By similarity), Has a high preference for hydroxycinnamates as substrates, Substrate preference is ferulic acid > p-coumaric acid > N-acetyl tyrosine methyl ester > N-acetyl-tyrosine > tyrosine > catechol > Gly-Tyr-Gly, May be involved in the formation of diferulate linkages in the plant cell wall (PubMed:16650004)

Belongs to the peroxidase family, Classical plant (class III) peroxidase subfamily


This is Alpha-toxin OD1 protein, from Yellow Iranian scorpion, contains 65 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, The toxin affect mammalian sodium channels Nav1,7/SCN9A (EC(50)=4,5 nM), Nav1,4/SCN4A (EC(50)=9,6 nM), Nav1,6/SCN8A (EC(50)=30 nM), Nav1,5/SCN5A (only at micromolar concentrations), and insect sodium channel para/tipE (EC(50)=80 nM) (PubMed:16038905, PubMed:16641312, PubMed:23527544), In vivo, intraplantar administration of this toxin elicits pain behaviors, including licking and flinching of the hind paw (PubMed:26999206)


This is Basic phospholipase A2 VRV-PL-V protein, from Russel's viper, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that has a low enzymatic activity, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is C-type natriuretic peptide protein, from Duckbill platypus, contains 121 amino acids, is soluble, locates in Extracellular.

Venom peptide 1 induces slow and continuous calcium influx in IMR-32 human neuroblastoma cells, Venom peptide 4 weakly induces calcium influx in IMR-32 human neuroblastoma cells while venom peptide 2 was not observed to induce calcium influx

In the C-terminal section; belongs to the natriuretic peptide family


This is Potassium channel toxin alpha-KTx 15.6 protein, from Venezuelan scorpion, contains 61 amino acids, is soluble, locates in Extracellular.

Irreversibly blocks the A-type voltage-gated potassium channels in rat cerebellum granular cells (190 nM induce 50% inhibitory effect) (IC(50)=190 nM) (PubMed:15369825, PubMed:18280256), Also weakly inhibits Kv1,2/KCNA2 and Kv1,3/KCNA3 (PubMed:29483648)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 15 subfamily


This is Lipolysis-activating peptide 1-alpha chain protein, from Common European scorpion, contains 91 amino acids, is soluble, locates in Extracellular.

The edited BmKBTx-like, similar to beta-toxins, may modulate voltage-gated sodium channels (Nav) and may block voltage-gated potassium channels (Kv)

Belongs to the long (3 C-C) scorpion toxin superfamily


This is Mu-conotoxin SrVA protein, from Alphabet cone, contains 59 amino acids, is soluble, locates in Extracellular.

Mu-conotoxins block voltage-gated sodium channels (PubMed:35940316), This peptide inhibits the cardiac sodium channel hNav1,5/SCN5A (33% inhibition at 200 nM, 50% at 400 nM, and 55% at 600 nM) (PubMed:35940316), Does not interfere with the voltage-dependence of activation, but affects the voltage-dependence of inactivation of hNav1,5 (PubMed:35940316), In vivo, intracranial injection into 9-day-old mice causes transient symptoms, including extension of the body and clockwise and counter-clockwise turns, that last 3 to 4 minutes (PubMed:16297502), Intracranial injection into 16-day-old mice, causes transient symptoms, including agitated breathing and occasional turning followed by scratching and grooming behavior, that last for 15-19 minutes (PubMed:16297502)


This is Toxin AdTx1 protein, from Eastern green mamba, contains 65 amino acids, is soluble, locates in Extracellular.

Orthosteric antagonist of the alpha-1A adrenergic receptor (ADRA1A) with an affinity of 0,35 nM (PubMed:20015090), Has also affinity for ADRA1B > ADRA2C > ADRA1D (PubMed:23935897), Acts as a relaxant of smooth muscle, Reduces prostatic muscle tone as efficiently as tamsulosin (an antagonist presently used), but with fewer cardiovascular side effects (PubMed:23005263)

Belongs to the snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily


This is MAM domain-containing glycosylphosphatidylinositol anchor protein 1 protein, from Rat, contains 956 amino acids, has 6 Ig-like Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Ig-like

Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity), Plays a role in the formation or maintenance of inhibitory synapses, May function by inhibiting the activity of NLGN2


This is M-zodatoxin-Lt8a protein, from Spider, contains 129 amino acids, is soluble, locates in Extracellular.

Insecticidal, cytolytic and antimicrobial peptide (PubMed:18215128, PubMed:27287558), Has insecticidal activity against the flesh fly S,carnaria, and against the cockroach N,cinerea (PubMed:18215128), Has insecticidal activity against D,melanogaster (PubMed:27287558), Has hemolytic activity against human erythrocytes (EC(50)=6 uM) (PubMed:18215128), Has cytolytic activity against insect Sf9 cells (EC(50)=1 uM) and human leukocytes (EC(50)=3 uM) (PubMed:18215128), Has antibacterial activity against the Gram-positive bacteria A,globiformis VKM Ac-1112 (MIC=0,5 uM), and B,subtilis VKM B-501 (MIC=0,6-0,9 uM), and against the Gram-negative bacteria E,coli C600 (MIC=0,5 uM), E,coli DH5alpha (MIC=0,9 uM), E,coli MH1 (MIC=0,5 uM), P,aeruginosa PAO1 (MIC=1,9 uM), and P,fluorescens VKM B-894 (MIC=3,8 uM) (PubMed:18215128, PubMed:27287558), Lacks antimicrobial activity against the Gram-positive bacteria M,luteus and S,aureus, and against the Gram-negative bacterium S,marcescens (PubMed:18215128), Forms voltage-dependent, ion-permeable channels in membranes (PubMed:18215128), At high concentration causes cell membrane lysis (PubMed:18215128)

Belongs to the cationic peptide 06 (cytoinsectotoxin) family


This is Snake venom metalloproteinase BmooMPalpha-I protein, from Lance-headed viper, contains 205 amino acids, is soluble, locates in Extracellular.

Snake venom zinc metalloproteinase that cleaves the alpha chain of fibrinogen (FGA) first followed by the beta chain (FGB) and shows no effect on the gamma chain, Cleaves only the beta chain of fibrin, leaving the gamma-dimer untouched, Shows proteolytic activity towards azocasein, Causes defibrinogenation when intraperitoneally administered on mice

Belongs to the venom metalloproteinase (M12B) family, P-I subfamily


This is Snake venom metalloproteinase atroxlysin-1 protein, from Barba amarilla, contains 202 amino acids, is soluble, locates in Extracellular.

Snake venom zinc metalloproteinase that acts on fibrinogen, fibrin, fibronectin (FN1), type I collagen, type IV collagen, integrin alpha-7/beta-1 (ITGA7/ITGB1) and integrin alpha-1/beta-1 (ITGA1/ITGB1), Binds to fibronectin (FN1), fibrinogen and, weakly, to type I collagen and laminin, Cleaves Xaa-Leu bonds, Inhibits ADP- and collagen-induced platelet aggregation both in the presence (IC(50)=1,4 uM for collagen) and in the absence (IC(50)=2,2 uM for collagen) of cofactors, Has hemorrhagic activity


This is 6-phosphogluconate dehydrogenase, decarboxylating protein, from Rat, contains 483 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

Belongs to the 6-phosphogluconate dehydrogenase family


This is Purine nucleoside phosphorylase protein, from Rat, contains 289 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity), Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine (By similarity)

Belongs to the PNP/MTAP phosphorylase family


This is Hyaluronidase-1 protein, from Manchurian scorpion, contains 410 amino acids, is soluble, locates in Extracellular.

Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides, In venom, it may participate in the degradation of the extracellular matrix thus allowing a rapid spread of other venom components during the envenomation process

Belongs to the glycosyl hydrolase 56 family


This is Eumenine mastoparan-OD protein, from Solitary wasp, contains 79 amino acids, is soluble, locates in Extracellular.

Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations, Also exhibits strong antimicrobial activity against the fungi C,albicans and B,cinerea, and weaker activity against the Gram-negative bacterium E,coli and Gram-positive bacterium S,aureus

Belongs to the MCD family, Mastoparan subfamily


This is Venom peptide 2-long protein, from Solitary wasp, contains 71 amino acids, is soluble, locates in Extracellular.

Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations, Also exhibits strong antimicrobial activity against the fungi B,cinerea (MIC=0,5 ug/ml) and C,albicans, and moderate activity against the Gram-positive bacterium S,aureus (MIC=25 ug/ml) and the Gram-negative bacterium E,coli, Venom peptide 2-long has substantially lower antimicrobial activity against C,albicans (MIC=100 ug/ml) and bacteria than Orancis-protonectin but has equivalent activity against B,cinerea (MIC=0,5 ug/ml)

Belongs to the MCD family, Protonectin subfamily


This is Basic phospholipase A2 A protein, from South American rattlesnake, contains 122 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A that has strong antimicrobial activity against the Gram-negative bacterium X,axonopodis, Antimicrobial activity is not abolished by EDTA or p-BPB and is therefore not strongly dependent on the enzymatic activity, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is Hydroxyacyl-thioester dehydratase type 2, mitochondrial protein, from Human, contains 168 amino acids, locates in Mitochondrion.

Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis


This is Sodium channel neurotoxin MeuNaTxalpha-1 protein, from Lesser Asian scorpion, contains 85 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission, This toxin inhibits inactivation of Nav1,6/SCN8A (EC(50)=3,1 uM) and drosophila DmNav1 (EC(50)=1,17 uM) (PubMed:21969612, Ref,2, PubMed:33051988), It also shows a weak inhibition of inactivation on Nav1,2/SCN2A Nav1,3/SCN3A, and Nav1,7/SCN9A (PubMed:21969612, PubMed:33051988), The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612), The toxin has also been shown to dose-dependently stimulates intracellular signaling in DRG neurons through activation of two kinases (type II protein kinase A (PKA-II) and MAP kinases 1/3 (MAPK1/MAPK3)) (PubMed:33051988), Nav1,2/SCN2A is strongly suggested to be the target channel predominantly involved in this activation (PubMed:33051988), In vivo, the toxin induces a dose-dependent thermal hyperalgesia lasting 30-45 minutes (PubMed:33051988)


This is Basic phospholipase A2 homolog BaTX protein, from Urutu, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 homolog that lacks enzymatic activity (PubMed:17270350), Is myotoxic and displays edema-inducing activities (PubMed:17270350, PubMed:17915277), In vitro, produced time-dependent, irreversible neuromuscular blockade in isolated mouse phrenic nerve-diaphragm and chick biventer cervicis preparations (PubMed:17270350, PubMed:19463969), A model of myotoxic mechanism has been proposed: an apo Lys49-PLA2 is activated by the entrance of a hydrophobic molecule (e,g, fatty acid) at the hydrophobic channel of the protein leading to a reorientation of a monomer (By similarity), This reorientation causes a transition between 'inactive' to 'active' states, causing alignment of C-terminal and membrane-docking sites (MDoS) side-by-side and putting the membrane-disruption sites (MDiS) in the same plane, exposed to solvent and in a symmetric position for both monomers (By similarity), The MDoS region stabilizes the toxin on membrane by the interaction of charged residues with phospholipid head groups (By similarity), Subsequently, the MDiS region destabilizes the membrane with penetration of hydrophobic residues (By similarity), This insertion causes a disorganization of the membrane, allowing an uncontrolled influx of ions (i,e, calcium and sodium), and eventually triggering irreversible intracellular alterations and cell death (By similarity)

Belongs to the phospholipase A2 family, Group II subfamily, K49 sub-subfamily


This is Defensin Lucifensin protein, from Green bottle fly, contains 92 amino acids, is soluble, locates in Extracellular.

Shows strong antibacterial activity against numerous Gram-positive bacteria, It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130), Shows antibacterial activity against the Gram-positive bacteria M,luteus, E,fecalis (MIC=32 mg/L), S,aureus (MIC=16 mg/L), S,carnosus (MIC=2 mg/L), S,pneumoniae (MIC=2 mg/L) and S,pyogenes (MIC=2 mg/L) and against a number of methicillin-resistant S,aureus and glycopeptide-intermediate S,aureus isolates (PubMed:20542901, PubMed:19921400, PubMed:21560219), Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C,utilis (PubMed:20542901), Shows slight antifungal activity against C,albicans (PubMed:21560219)

Belongs to the invertebrate defensin family, Type 1 subfamily


This is Snake venom metalloproteinase HF-1 protein, from Marajo lancehead, contains 238 amino acids, is soluble, locates in Extracellular.

Snake venom zinc metalloprotease that is weakly hemorrhagic and has Aalpha, Bbeta fibrinogenolytic activities, Cleaves the Aalpha chain of fibrinogen first, followed by the Bbeta chain and shows no effect on the gamma chain, Has caseinolytic activity, Induces dose-dependent edema


This is Basic phospholipase A2 BmjeTX-I protein, from Marajo lancehead, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that induces a slight blockade of neuromuscular contraction in an indirectly stimulated chick biventer cervicis nerve-muscle preparation, Does not inhibit contraction of chick biventer cervicic nerve-muscle preparation in response to treatment with acetylcholine or KCl, The neuromuscular blockade is mediated by inhibitory action at the presynaptic motor nerve endings, Lyses skeletal myoblasts and myotubes in vitro, and intramuscular injection causes local muscle necrosis, Induces edema in the mouse foot pad, Induces a transient increase of IL-6 levels, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is Basic phospholipase A2 BmjeTX-II protein, from Marajo lancehead, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that induces blockade of neuromuscular contraction in an indirectly stimulated chick biventer cervicis nerve-muscle preparation, Does not inhibit contraction of chick biventer cervicic nerve-muscle preparation in response to treatment with acetylcholine or KCl, The neuromuscular blockade is mediated by inhibitory action at the presynaptic motor nerve endings, Lyses skeletal myoblasts and myotubes in vitro, and intramuscular injection causes local muscle necrosis, Induces edema in the mouse foot pad, Induces a transient increase of IL-6 levels, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is Basic phospholipase A2 9 protein, from South American rattlesnake, contains 122 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that has a strong dose-dependent anticoagulant effect, Intramuscular and intervenal injection causes muscle necrosis, Induces moderate edema in the mouse foot pad, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is Basic phospholipase A2 10 protein, from South American rattlesnake, contains 122 amino acids, is soluble, locates in Extracellular.


This is Tityustoxin-19 protein, from Brazilian scorpion, contains 91 amino acids, is soluble, locates in Extracellular.

Shows cytolytic effects on erythrocytes, In addition, induces non-selective pores formation when high concentrations (300 nM) are applied on oocytes

Belongs to the long chain scorpion toxin family, Class 2 subfamily


This is Acidic phospholipase A2 protein, from Yararanata, contains 122 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that displays low systemic toxicity and causes severe symptoms only at very high concentrations (15 mg/kg), Has neither coagulant nor anticoagulant activity, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is RNA-editing ligase 2, mitochondrial protein, from Trypanosoma brucei brucei, contains 416 amino acids, locates in Mitochondrion.

RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs


This is RNA-editing ligase 1, mitochondrial protein, from Trypanosoma brucei brucei, contains 469 amino acids, locates in Mitochondrion.

Essential for RNA editing, RNA editing in kinetoplastid mitochondria inserts and deletes uridylates at multiple sites in pre-mRNAs as directed by guide RNAs


This is Zinc metalloproteinase barnettlysin-1 protein, from Barnett's lancehead, contains 202 amino acids, is soluble, locates in Extracellular.

Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen and fibrin but has no activity on beta- and gamma-chains, Cleaves X-Leu bonds, Inhibits platelet aggregation induced by the von Willebrand factor (VWF) (IC(50) is 1,4 uM) and type I collagen (IC(50) is 3,2 uM), Acts by cleaving the vWF and its receptor GPIb, and by cleaving the collagen-binding Alpha-2A domain of the collagen receptor alpha-2/beta-1 integrin (ITGA2/ITGB1), Also degrades the extracellular matrix protein fibronectin (FN1), but has no effect on laminin and type I collagen


This is pH-regulated antigen PRA1 protein, from Yeast, contains 299 amino acids, is soluble, locates in Extracellular.

Cell surface protein involved in the host-parasite interaction during candidal infection, With MP65, represents a major component of the biofilm matrix, Sequesters zinc from host tissue and mediates leukocyte adhesion and migration, As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation, As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance, Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation, Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2, Decreases complement-mediated adhesion, as well as uptake of C,albicans by human macrophages


This is F-box/WD repeat-containing protein pof1 protein, from Fission yeast, contains 605 amino acids, locates in Nucleus.

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation, Required for the inactivation of zip1 via ubiquitination


This is WD repeat-containing protein pop1 protein, from Fission yeast, contains 775 amino acids, locates in Nucleus.

Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18, Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation, Together with pop2, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells, Regulates cell-cycle progression under starvation through the rum1 protein


This is Mitochondrial import inner membrane translocase subunit TIM10 protein, from Baker's yeast, contains 93 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane, Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space, Compared to TIM9, it may function as a substrate sensor


This is DNA polymerase epsilon subunit D protein, from Fission yeast, contains 210 amino acids, locates in Nucleus.

As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication, It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork, It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication, It is also involved in DNA synthesis during DNA repair (By similarity), The dpb3-dpb4 dimer associates with histone deacetylases, chromatin remodelers, and histones and plays a crucial role in the inheritance of histone hypoacetylation and H3K9 methylation in heterochromatin (PubMed:29109278), The dpb3-dpb4 dimer is also required for the recruitment of sir2 to heterochromatin (PubMed:29109278)


This is E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 protein, from Fission yeast, contains 269 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains, Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression, Involved in stabilizing, restarting or resolving transiently stalled replication forks, Prevents accumulation of DNA damage during cell cycle progression (By similarity)


This is Inner kinetochore subunit mis6 protein, from Fission yeast, contains 672 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (PubMed:10398680), Required for the localization of cnp1 to the centromere (PubMed:10864871)


This is Crossover junction endonuclease mus81 protein, from Fission yeast, contains 608 amino acids, locates in Nucleus.

Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick, Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions, May be required in mitosis for the processing of stalled or collapsed replication fork intermediates, May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)


This is Karyogamy meiotic segregation protein 1 protein, from Fission yeast, contains 607 amino acids, is soluble, locates in Cytoplasm.

Has a role in karyogamy, recombination and segregation during meiosis, Although it has been shown to associate with the spindle pole body it is unlikely to be involved in its formation or maintenance


This is Protein msp1, mitochondrial protein, from Fission yeast, contains 903 amino acids, is membrane-bound, locates in Mitochondrion.

Dynamin-related GTPase required for mitochondrial fusion, Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane (By similarity)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Nucleoside diphosphate kinase, mitochondrial protein, from Rock dove, contains 181 amino acids, is membrane-bound, locates in Mitochondrion.

Major role in the synthesis of nucleoside triphosphates other than ATP, The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate, Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis, Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity, Acts as mitochondria-specific NDK coupled to respiration, Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (By similarity)


This is T-box protein VegT-A protein, from African clawed frog, contains 455 amino acids, locates in Nucleus.

Transcription factor required for both mesoderm and endoderm formation in the embryo; signaling determinants and concentration levels may determine which germ layer is formed, Acts together with beta-catenin to activate genes that are responsible for mesoderm induction including wnt-8, eomes t/bra, siamois, mix1 and sox17, Directly binds to promoter DNA, Patterns the mesoderm along the dorsoventral and posterior axis, Activates siamois gene transcription when alone or in combination with beta-catenin, but inhibits siamois transcription in combination with pou5f1,1/oct-25


This is Intermediate filament protein ifa-1 protein, from Caenorhabditis elegans, contains 575 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells, Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis

Belongs to the intermediate filament family


This is Probable histone-binding protein lin-53 protein, from Caenorhabditis elegans, contains 417 amino acids, locates in Nucleus.

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity), Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation (PubMed:25446273, PubMed:26904949), Synthetic multivulva class B (synMuvB) protein (PubMed:9875852), SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription (PubMed:10704416, PubMed:17075059, PubMed:9875852)

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family


This is Resistance to inhibitors of cholinesterase protein 19 protein, from Caenorhabditis elegans, contains 430 amino acids, is soluble, locates in Cytoplasm.

May be involved in neurotransmitter secretion (PubMed:11029035), In association with the GTPase activator protein tbc-8 activates rab-2 during dense core vesicle maturation in cholinergic motoneurons (PubMed:22654674)


This is Importin subunit alpha-2 protein, from Caenorhabditis elegans, contains 531 amino acids, is soluble, locates in Cytoplasm.

Nuclear transport receptor that mediates nuclear import of proteins, and which is involved in sister chromatid cohesion (PubMed:11311162, PubMed:12221121, PubMed:30563860), Binds specifically and directly to substrates containing either a simple or bipartite nuclear localization signals (NLS) motif (By similarity), Promotes docking of import substrates to the nuclear envelope (By similarity), Together with akir-1 adapter, required for the import and load of cohesin complex proteins in meiotic nuclei (PubMed:30563860)


This is Defensin-A protein, from Yellowfever mosquito, contains 98 amino acids, is soluble, locates in Extracellular.

Antibacterial peptide mostly active against Gram-positive bacteria, Has activity against the bacteria Gram-negative E,cloacae beta12


This is MICOS complex subunit Mic60 protein, from Fruit fly, contains 739 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity)

Belongs to the MICOS complex subunit Mic60 family


This is Protein lin-28 protein, from Caenorhabditis elegans, contains 227 amino acids, has 2 CCHC-type Zinc finger, is soluble, locates in Cytoplasm.

CCHC-type

CCHC-type

Heterochronic protein which controls the choice of stage specific cell fates (PubMed:9054503, PubMed:6494891, PubMed:2702689, PubMed:2628162, PubMed:1916265, PubMed:7671811, PubMed:8625405, PubMed:8756295, PubMed:8756296, PubMed:9477318, PubMed:9649524, PubMed:10706289, PubMed:12871707, PubMed:15073154, PubMed:16139228), Regulates the timing of the second larval stage events (L2 events) in the hypodermis (PubMed:2702689, PubMed:2628162), May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3 (PubMed:10706289, PubMed:12871707, PubMed:16139228), Through this regulatory role, controls the timing of the sexual maturation of the nervous system (PubMed:31264582), Also has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153), Plays a role in governing the developmental timing of male tail tip morphogenesis (PubMed:26811380, PubMed:30956008), Plays a role in controlling the seam cell number during larval stages (PubMed:21471153, PubMed:28602583), Plays a role in vulval development (PubMed:28602583)


This is Protein stand still protein, from Fruit fly, contains 321 amino acids, locates in Nucleus.

Essential in the female germline for proper survival, sex determination and differentiation, Participates in the transcriptional activation of Otu, Does not regulate the expression of Ovo


This is Negative elongation factor E protein, from Fruit fly, contains 280 amino acids, locates in Nucleus.

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II, The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing


This is Cell division cycle 5-like protein protein, from Mouse-ear cress, contains 844 amino acids, locates in Nucleus.

Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity, Possesses a sequence specific DNA sequence 'CTCAGCG' binding activity, Involved in mRNA splicing and cell cycle control, May also play a role in the response to DNA damage


This is Ferric reduction oxidase 2 protein, from Mouse-ear cress, contains 725 amino acids, is membrane-bound, locates in Cell membrane.

Flavocytochrome that transfers electrons across the plasma membrane to reduce ferric iron chelates to form soluble ferrous iron in the rhizosphere, May be involved in the delivery of iron to developing pollen grains, Acts also as a copper-chelate reductase, Involved in glycine betaine-mediated chilling tolerance and reactive oxygen species accumulation

Belongs to the ferric reductase (FRE) family


This is Serine/arginine-rich splicing factor RS31 protein, from Mouse-ear cress, contains 264 amino acids, is soluble, locates in Nucleus.

Required for constitutive and alternative pre-mRNA splicing

Belongs to the splicing factor SR family, RS subfamily


This is Serine/arginine-rich splicing factor RS40 protein, from Mouse-ear cress, contains 350 amino acids, locates in Nucleus.

Required for constitutive and alternative pre-mRNA splicing (Probable), Involved in primary miRNA processing and pri-miRNA biogenesis, Binds both intronless and intron-containing pri-miRNAs (PubMed:26227967)


This is Protein CCA1 protein, from Mouse-ear cress, contains 608 amino acids, locates in Nucleus.

Transcription factor involved in the circadian clock and in the phytochrome regulation, Binds to the promoter regions of APRR1/TOC1 and TCP21/CHE to repress their transcription, Binds to the promoter regions of CAB2A and CAB2B to promote their transcription, Represses both LHY and itself, Recognizes the promoter of JMJ14 to regulates its expression during the night in a circadian manner (PubMed:31429787), Binds to the promoter of BHLH80/FBH1 and regulates its expression in response to warm temperature, thus contributing to temperature compensation of the circadian clock (PubMed:25246594)


This is Proline dehydrogenase 1, mitochondrial protein, from Mouse-ear cress, contains 499 amino acids, locates in Mitochondrion.

Converts proline to delta-1-pyrroline-5-carboxylate


This is Aquaporin PIP2-7 protein, from Mouse-ear cress, contains 280 amino acids, is membrane-bound, locates in Cell membrane.

Water channel required to facilitate the transport of water across cell membrane, May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition

Belongs to the MIP/aquaporin (TC 1,A,8) family, PIP (TC 1,A,8,11) subfamily


This is Fumarate hydratase 1, mitochondrial protein, from Mouse-ear cress, contains 492 amino acids, locates in Mitochondrion.

Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:29688630), Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (By similarity)

Belongs to the class-II fumarase/aspartase family, Fumarase subfamily


This is Syntaxin-22 protein, from Mouse-ear cress, contains 268 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May provide the t-SNARE function in the vacuolar assembly, Promotes the formation of vacuolar membrane 'bulbs', Required for inflorescence stem gravitropism


This is Early light-induced protein 1, chloroplastic protein, from Mouse-ear cress, contains 195 amino acids, is membrane-bound, locates in Plastid.

Prevents excess accumulation of free chlorophyll by inhibiting the entire chlorophyll biosynthesis pathway (e,g, 5-aminolevulinate synthesis and Mg-protoporphyrin IX chelatase activity), and hence prevent photooxidative stress (By similarity), Probably involved in the integration of pigments into the mature light-harvesting pigment-protein complexes, Light-harvesting chlorophyll (LHC) a/b-binding protein required to ensure a high rate of chlorophyll accumulation during deetiolation in continuous high light, Involved in seed germination, May fulfill a photoprotective functions


This is Nudix hydrolase 23, chloroplastic protein, from Mouse-ear cress, contains 280 amino acids, locates in Plastid.

Mediates the hydrolysis of some nucleoside diphosphate derivatives, Can use FAD and ADP-ribose as substrates


This is Histone-lysine N-methyltransferase CLF protein, from Mouse-ear cress, contains 902 amino acids, locates in Nucleus.

Polycomb group (PcG) protein, Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes, mainly abscisic acid (ABA) responsive elements (PubMed:17881378, PubMed:30307069), Required to regulate floral development by repressing the AGAMOUS homeotic gene in leaves, inflorescence stems and flowers (PubMed:17881378), Together with ATX1, modulates AG nucleosome methylation statement (PubMed:17881378), Regulates the antero-posterior organization of the endosperm, as well as the division and elongation rates of leaf cells, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, Forms a nuclear complex with EZA1/SWN and HXK1 to target common glucose-responsive genes and regulate glucose signaling by glucose-mediated gene repression (PubMed:35394700), Affects the recruitment of HXK1 to the target chromatin (PubMed:35394700)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily


This is Hexokinase-2 protein, from Mouse-ear cress, contains 502 amino acids, is membrane-bound, locates in Mitochondrion.

Fructose and glucose phosphorylating enzyme (PubMed:9014361), May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (PubMed:9014361), Acts as sugar sensor which may regulate sugar-dependent gene repression or activation (PubMed:9014361), Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism (PubMed:9014361), May regulate the execution of program cell death in plant cells (PubMed:16920781)


This is 4-hydroxyphenylpyruvate dioxygenase protein, from Mouse-ear cress, contains 445 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism


This is Cytosolic beta-glucosidase protein, from Guinea pig, contains 469 amino acids, is soluble, locates in Cytoplasm.

Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (Probable), Has a significant glucosylceramidase activity in vitro, However, that activity is relatively low and its significance in vivo is not clear (By similarity), Hydrolyzes galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph, However, the in vivo relevance of these activities is unclear (By similarity), It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics (Probable), Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor (By similarity), Could also play a role in the catabolism of cytosolic sialyl free N-glycans (By similarity)

Belongs to the glycosyl hydrolase 1 family, Klotho subfamily


This is Serine/threonine-protein kinase Kist protein, from Mouse, contains 419 amino acids, locates in Nucleus.

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase, May be involved in trafficking and/or processing of RNA (By similarity)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Histone RNA hairpin-binding protein protein, from Mouse, contains 275 amino acids, locates in Cytoplasm.

RNA-binding protein involved in the histone pre-mRNA processing (PubMed:18036581), Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) (PubMed:18036581), Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery (By similarity), Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression (By similarity), Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis (PubMed:18036581), Binds to the 5' side of the stem-loop structure of histone pre-mRNAs (PubMed:19470752)


This is Neuronal PAS domain-containing protein 2 protein, from Mouse, contains 816 amino acids, locates in Nucleus.

Transcriptional activator which forms a core component of the circadian clock, The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior, It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function, Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system, Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'), The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN, The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle, Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day, Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle), A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively, Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging, A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism, Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters, The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression, This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively, The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina, NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability, Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes, Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (PubMed:25212631), Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (PubMed:29163035)


This is Aurora kinase A protein, from Mouse, contains 395 amino acids, is soluble, locates in Cytoplasm.

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (By similarity), Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:9245792, PubMed:19075002), Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity), Required for initial activation of CDK1 at centrosomes (By similarity), Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (By similarity), Regulates KIF2A tubulin depolymerase activity (By similarity), Required for normal axon formation (By similarity), Plays a role in microtubule remodeling during neurite extension (PubMed:19668197), Important for microtubule formation and/or stabilization (By similarity), Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (By similarity), Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity), Inhibits cilia outgrowth (By similarity), Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:20643351), Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily


This is 5-demethoxyubiquinone hydroxylase, mitochondrial protein, from Mouse, contains 217 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis, Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity), Involved in lifespan determination in a ubiquinone-independent manner (PubMed:19478076), Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis


This is Endothelial PAS domain-containing protein 1 protein, from Mouse, contains 874 amino acids, locates in Nucleus.

Transcription factor involved in the induction of oxygen regulated genes, Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371), Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung, May also play a role in the formation of the endothelium that gives rise to the blood brain barrier, Potent activator of the Tie-2 tyrosine kinase expression, Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300, Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity)


This is Glycerol-3-phosphate acyltransferase 1, mitochondrial protein, from Rat, contains 828 amino acids, is membrane-bound, locates in Mitochondrion.

Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids


This is Thioredoxin, mitochondrial protein, from Rat, contains 166 amino acids, locates in Mitochondrion.

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability, Possesses a dithiol-reducing activity


This is Urea transporter 1 protein, from Rat, contains 384 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the transport of urea driven by a concentration gradient across the cell membrane (PubMed:8982255), Mediates the transport of urea across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity), Facilitates water transport in erythrocytes (By similarity)


This is Growth/differentiation factor 10 protein, from Mouse, contains 476 amino acids, is soluble, locates in Extracellular.

Growth factor involved in osteogenesis and adipogenesis, Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway (PubMed:22155034), Plays an inhibitory role in the process of adipogenesis (PubMed:21712809)


This is Mannan-binding lectin serine protease 1 protein, from Mouse, contains 704 amino acids, is soluble, locates in Extracellular.

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them, The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2, Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction, Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5, Also plays a role in development


This is RNA-binding protein 10 protein, from Human, contains 930 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type; atypical Zinc finger, locates in Nucleus.

C2H2-type; atypical

May be involved in post-transcriptional processing, most probably in mRNA splicing, Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity), May bind to specific miRNA hairpins (PubMed:28431233)


This is Calcium-transporting ATPase type 2C member 1 protein, from Human, contains 919 amino acids, is membrane-bound, locates in Golgi apparatus.

ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:16192278, PubMed:30923126, PubMed:21187401, PubMed:12707275, PubMed:20439740), Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side, The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126), Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:20439740, PubMed:14632183), Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:14632183, PubMed:10615129, PubMed:20439740), Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity), May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401)

Belongs to the cation transport ATPase (P-type) (TC 3,A,3) family, Type IIA subfamily


This is Methyl-CpG-binding protein 2 protein, from Rat, contains 492 amino acids, locates in Nucleus.

Chromosomal protein that binds to methylated DNA, It can bind specifically to a single methyl-CpG pair, It is not influenced by sequences flanking the methyl-CpGs, Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A, Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)


This is Norrin protein, from Human, contains 133 amino acids, is soluble, locates in Extracellular.

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor, Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs, Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1), May be involved in a pathway that regulates neural cell differentiation and proliferation, Possible role in neuroectodermal cell-cell interaction


This is Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial protein, from Baker's yeast, contains 640 amino acids, is membrane-bound, locates in Mitochondrion.

Catalytic subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q), SDH1 and SDH2 form the catalytic dimer, Electrons flow from succinate to the FAD bound to SDH1, and sequentially through the iron-sulfur clusters bound to SDH2 and enter the membrane dimer formed by SDH3 and SDH4

Belongs to the FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily


This is Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit protein, from Baker's yeast, contains 495 amino acids, is soluble, locates in Cytoplasm.

Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process, Can function independently of the complex

Belongs to the glycosyltransferase 20 family


This is Vasopressin V2 receptor protein, from Rat, contains 371 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for arginine vasopressin, The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:1534150), Involved in renal water reabsorption (By similarity)

Belongs to the G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily


This is Alpha-1-antitrypsin 1-3 protein, from Mouse, contains 412 amino acids, is soluble, locates in Extracellular.

Inhibitor of serine proteases, Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase


This is Alpha-1-antitrypsin 1-4 protein, from Mouse, contains 413 amino acids, is soluble, locates in Extracellular.


This is Alpha-1-antitrypsin 1-5 protein, from Mouse, contains 413 amino acids, is soluble, locates in Extracellular.

Does not inhibit elastase or chymotrypsin, No target protease has been identified to date


This is DNA-directed RNA polymerase I subunit RPA49 protein, from Baker's yeast, contains 415 amino acids, locates in Nucleus.

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors, Besides, RNA polymerase I has intrinsic RNA cleavage activity, The heterodimer formed by RPA34 and RPA49 stimulates transcript elongation by Pol I, Subunit RPA49 can bind both single-stranded and double-stranded DNA

Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family


This is Serine/arginine-rich splicing factor 2 protein, from Human, contains 221 amino acids, is soluble, locates in Nucleus.

Necessary for the splicing of pre-mRNA, It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly, It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA, Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF, Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3', Can bind to beta-globin mRNA and commit it to the splicing pathway, The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment

Belongs to the splicing factor SR family


This is Cyclic AMP-responsive element-binding protein 1 protein, from Mouse, contains 327 amino acids, locates in Nucleus.

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters, Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation, Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells


This is Ketol-acid reductoisomerase, chloroplastic protein, from Spinach, contains 595 amino acids, locates in Plastid.

Belongs to the ketol-acid reductoisomerase family


This is Histone promoter control protein 2 protein, from Baker's yeast, contains 625 amino acids, locates in Nucleus.

Component of the HIR complex, which functions as a histone chaperone that cooperates with ASF1 to promote replication-independent chromatin assembly, The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B, DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex, The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1


This is Peripheral myelin protein 22 protein, from Human, contains 160 amino acids, is membrane-bound, locates in Cell membrane.

Might be involved in growth regulation, and in myelinization in the peripheral nervous system


This is Cytochrome c oxidase subunit 12, mitochondrial protein, from Baker's yeast, contains 83 amino acids, is soluble, locates in Mitochondrion.

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation, The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase, Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water, Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of COX2 and heme A of COX1 to the active site in COX1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)), The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix

Belongs to the cytochrome c oxidase subunit 6B family


This is Serine/arginine (SR)-type shuttling mRNA binding protein NPL3 protein, from Baker's yeast, contains 414 amino acids, locates in Nucleus.

Involved in mRNA processing and export (PubMed:1429834, PubMed:8675010, PubMed:15542855, PubMed:19061647), Required for efficient splicing of a large set of pre-mRNAs by efficient co-transcriptional recruitment of the splicing machinery (PubMed:19061647, PubMed:23209445), Remains associated with the mRNP during early steps of translation elongation (PubMed:15542855)


This is Protein couch potato protein, from Fruit fly, contains 606 amino acids, locates in Nucleus.

May play a role in the development or function of the peripheral nervous system by regulating the processing of nervous system-specific transcripts


This is Chlorophyll a-b binding protein 6, chloroplastic protein, from Mouse-ear cress, contains 241 amino acids, is membrane-bound, locates in Plastid.

The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated

Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family


This is Ets DNA-binding protein pokkuri protein, from Fruit fly, contains 732 amino acids, locates in Nucleus.

Ets-related protein that functions as a negative regulator of photoreceptor development acting antagonistically to pnt and the proneural signal mediated by RAS (PubMed:1505027, PubMed:1495974, PubMed:8033205), It acts upstream of SINA to inhibit R7 development (PubMed:1505027, PubMed:1495974)


This is Magnesium transporter MRS2, mitochondrial protein, from Baker's yeast, contains 470 amino acids, is membrane-bound, locates in Mitochondrion.

High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix (PubMed:12628916, PubMed:17827224, PubMed:20653776, PubMed:23999289), Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing, It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes (PubMed:11544180)

Belongs to the CorA metal ion transporter (MIT) (TC 1,A,35) family


This is Sodium-dependent dopamine transporter protein, from Human, contains 620 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460), Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity), Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A3 subfamily


This is Penicillopepsin-1 protein, from Penicillium roqueforti, contains 397 amino acids, is soluble, locates in Extracellular.

Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates, The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site, Shows a broad primary substrate specificity, Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'


This is DNA-binding protein creA protein, from Aspergillus nidulans, contains 416 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB, Represses the transcription of the alcR, alcA and aldA genes by binding to a GC-rich region in their promoter, Also plays a role in response to carbon starvation and the control of extracellular proteases activity

Belongs to the creA/MIG C2H2-type zinc-finger protein family


This is Aquaporin-1 protein, from Mouse, contains 269 amino acids, is membrane-bound, locates in Cell membrane.

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:12133842), Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (By similarity)

Belongs to the MIP/aquaporin (TC 1,A,8) family


This is Myocyte-specific enhancer factor 2A protein, from Human, contains 507 amino acids, locates in Nucleus.

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes, Also involved in the activation of numerous growth factor- and stress-induced genes, Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival, Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription, In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation, Associates with chromatin to the ZNF16 promoter


This is Oxysterol-binding protein homolog 6 protein, from Baker's yeast, contains 448 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes, Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol, Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322, PubMed:16156791, PubMed:23934110, PubMed:26206936), Catalyzes the lipid countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM), Specifically exchanges phosphatidylserine (PS) with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation, Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport (PubMed:23934110, PubMed:26206936), Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936), Also binds phosphatidic acid (PA) (PubMed:16156791)


This is Protein MEH1 protein, from Baker's yeast, contains 184 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272), Component of the EGO complex, a complex involved in the regulation of microautophagy (PubMed:15989961)


This is Chromatin structure-remodeling complex subunit RSC4 protein, from Baker's yeast, contains 625 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton


This is Large ribosomal subunit protein eL6A protein, from Baker's yeast, contains 176 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL6 family


This is D-beta-hydroxybutyrate dehydrogenase, mitochondrial protein, from Bovine, contains 344 amino acids, is membrane-bound, locates in Mitochondrion.

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is U3 small nucleolar RNA-associated protein 6 protein, from Baker's yeast, contains 440 amino acids, locates in Nucleus.

Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor


This is NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial protein, from Bovine, contains 175 amino acids, is membrane-bound, locates in Mitochondrion.

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis, Complex I functions in the transfer of electrons from NADH to the respiratory chain, The immediate electron acceptor for the enzyme is believed to be ubiquinone

Belongs to the complex I NDUFS4 subunit family


This is Metal-response element-binding transcription factor 2 protein, from Mouse, contains 593 amino acids, has 2 PHD-type Zinc finger, locates in Nucleus.

PHD-type

PHD-type

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:20144788, PubMed:21367819, PubMed:21059868, PubMed:23104054, PubMed:22438827), Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (PubMed:20144788), Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (PubMed:21367819), Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (PubMed:21059868), In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (PubMed:21059868), Binds to the metal-regulating-element (MRE) of MT1A gene promoter (PubMed:7772254)


This is RNA-binding protein 1 protein, from Fruit fly, contains 144 amino acids, locates in Nucleus.

Contributes to the activation of female-specific DSX splicing in vivo by recognizing the RBP1 target sequences within the purine-rich polypyrimidine tract of the female-specific 3' splice site


This is Histone H1.1 protein, from Human, contains 215 amino acids, locates in Nucleus.

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber, Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers, Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)


This is Interferon regulatory factor 8 protein, from Human, contains 426 amino acids, locates in Nucleus.

Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:25122610), Can both act as a transcriptional activator or repressor (By similarity), Plays a negative regulatory role in cells of the immune system (By similarity), Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity), Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity), Positively regulates macroautophagy in dendritic cells (PubMed:29434592), Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity)


This is Vacuolar transporter chaperone 3 complex subunit 3 protein, from Baker's yeast, contains 835 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Accessory subunit of the vacuolar transporter chaperone (VTC) complex, The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP, VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046), The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046), PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834), The VTC complex also plays a role in vacuolar membrane fusion (PubMed:11102525, PubMed:11823419), Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419), Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules, Inositol polyphosphate binding promotes vacuolar polyphosphate synthesis (PubMed:27080106)


This is Increased recombination centers protein 15 protein, from Baker's yeast, contains 499 amino acids, is soluble, locates in Cytoplasm.

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family


This is Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase protein, from Human, contains 428 amino acids, is membrane-bound, locates in Golgi apparatus.

Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862), The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity), Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity), Can also act on glycolipid substrates, Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (By similarity), Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity)

Belongs to the glycosyltransferase 14 family


This is Eukaryotic initiation factor 4A protein, from Fruit fly, contains 403 amino acids, is soluble, locates in Cytoplasm.

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome, In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon, Involved in germ cell formation

Belongs to the DEAD box helicase family, eIF4A subfamily


This is Squalene synthase protein, from Rat, contains 416 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene (PubMed:9575210), Proceeds in two distinct steps, In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate, In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene, It is the first committed enzyme of the sterol biosynthesis pathway (By similarity)

Belongs to the phytoene/squalene synthase family


This is Mitochondrial import inner membrane translocase subunit TIM50 protein, from Baker's yeast, contains 476 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane, Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex, Does not act as a structural subunit of the TIM23 complex but plays a dynamic role in protein import, Has no phosphatase activity


This is Monothiol glutaredoxin-5, mitochondrial protein, from Baker's yeast, contains 150 amino acids, is soluble, locates in Mitochondrion.

Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:11950925, PubMed:12730244, PubMed:23615440), Receives 2Fe/2S clusters from scaffold protein ISU1 and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:27532773, PubMed:23615440)

Belongs to the glutaredoxin family, Monothiol subfamily


This is Ras association domain-containing protein 7 protein, from Human, contains 373 amino acids, is soluble, locates in Cytoplasm.

Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK, Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway, Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization


This is Inner membrane assembly complex subunit 17 protein, from Baker's yeast, contains 182 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase, INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain


This is Nucleolar GTP-binding protein 1 protein, from Baker's yeast, contains 647 amino acids, locates in Nucleus.

Involved in the biogenesis of the 60S ribosomal subunit

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, NOG subfamily


This is Calphotin protein, from Fruit fly, contains 864 amino acids, is soluble, locates in Cytoplasm.

Plays important roles in both rhabdomere development and in photoreceptor cell survival, Might function as a calcium-sequestering 'sponge' to regulate the amount of free cytoplasmic calcium, It binds 0,3 mole of Ca(2+) per mole of protein


This is NET1-associated nuclear protein 1 protein, from Baker's yeast, contains 896 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)


This is Small ribosomal subunit protein bS1m protein, from Baker's yeast, contains 344 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane, bS1m functionally interacts with the 5'-UTR of mitochondrial mRNAs

Belongs to the bacterial ribosomal protein bS1 family


This is NF-kappa-B inhibitor cactus protein, from Fruit fly, contains 500 amino acids, is soluble, locates in Cytoplasm.

Involved in the formation of the dorsoventral pattern, It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo, Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway, Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation

Belongs to the NF-kappa-B inhibitor family


This is Iron sulfur cluster assembly protein 1, mitochondrial protein, from Baker's yeast, contains 165 amino acids, is soluble, locates in Mitochondrion.

Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins, First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2, In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins, Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH, Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1, ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (PubMed:10588895, PubMed:12970193, PubMed:14741370, PubMed:15123690, PubMed:16341089, PubMed:16431909, PubMed:23615440, PubMed:25358379), Also involved in production of a sulfur precursor required for thiolation of cytoplasmic tRNAs (PubMed:31040179)