This is Muscle, skeletal receptor tyrosine-protein kinase protein, from Mouse, contains 868 amino acids, has 3 Ig-like Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Ig-like

Ig-like

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle, Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May positively regulate Rho family GTPases through FNTA, Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is Frizzled-4 protein, from Mouse, contains 537 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for Wnt proteins (PubMed:10097073), Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:19837033), Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (PubMed:19837033), In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (PubMed:19837033), A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, Both pathways seem to involve interactions with G-proteins, May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues, Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism

Belongs to the G-protein coupled receptor Fz/Smo family


This is Microtubule-associated protein RP/EB family member 1 protein, from Mouse, contains 268 amino acids, is soluble, locates in Cytoplasm.

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton, Promotes cytoplasmic microtubule nucleation and elongation, Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement, Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules, Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity), May play a role in cell migration (PubMed:15311282)


This is Lysosomal-associated transmembrane protein 5 protein, from Mouse, contains 261 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May have a special functional role during embryogenesis and in adult hematopoietic cells

Belongs to the LAPTM4/LAPTM5 transporter family


This is Transcription factor GATA-6 protein, from Mouse, contains 589 amino acids, has 2 GATA-type Zinc finger, locates in Nucleus.

GATA-type

GATA-type

Transcriptional activator that regulates SEMA3C and PLXNA2 (PubMed:19666519), May regulate genes that protect epithelial cells from bacterial infection (By similarity), Involved in gene regulation specifically in the gastric epithelium (By similarity), Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343), Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (PubMed:15329343)


This is Dual specificity tyrosine-phosphorylation-regulated kinase 1A protein, from Mouse, contains 763 amino acids, locates in Nucleus.

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:18938227, PubMed:20123978), Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (By similarity), Plays an important role in double-strand breaks (DSBs) repair following DNA damage (By similarity), Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (By similarity), Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity), May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity), Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity), Has pro-survival function and negatively regulates the apoptotic process (PubMed:20167603), Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (PubMed:20167603), This in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603), Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (PubMed:18938227)

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily


This is Sodium-dependent dopamine transporter protein, from Mouse, contains 619 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:12606774), Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity), Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (PubMed:30936473)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A3 subfamily


This is CMP-sialic acid transporter protein, from Mouse, contains 336 amino acids, is membrane-bound, locates in Golgi apparatus.

Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP (PubMed:8755516, PubMed:10085119, PubMed:30985278, PubMed:34015330), Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP (PubMed:30985278), Also able to exchange CMP-sialic acid for AMP and UMP (By similarity), Also mediates the transport of CDP-ribitol (PubMed:34015330) (By similarity)

Belongs to the nucleotide-sugar transporter family, SLC35A subfamily


This is Transcription factor SOX-17 protein, from Mouse, contains 419 amino acids, locates in Nucleus.

Has no DNA-binding activity, and does not function as transcriptional activator


This is Forkhead box protein S1 protein, from Mouse, contains 329 amino acids, locates in Nucleus.

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters, May have a role in the organization of the testicular vasculature


This is Peptidyl-prolyl cis-trans isomerase FKBP10 protein, from Mouse, contains 581 amino acids, is soluble, locates in Endoplasmic reticulum.

PPIases accelerate the folding of proteins during protein synthesis


This is Leukocyte surface antigen CD47 protein, from Mouse, contains 303 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Adhesive protein that mediates cell-to-cell interactions (By similarity), Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (By similarity), Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:20610415, PubMed:23591719), Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621), Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (PubMed:20610415), Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity), Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity), Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity), Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (PubMed:15917238), Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764), In response to THBS1, negatively modulates wound healing (PubMed:18156939), Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (PubMed:23591719), May play a role in membrane transport and/or integrin dependent signal transduction (By similarity), May prevent premature elimination of red blood cells (PubMed:10856220)


This is Potassium voltage-gated channel subfamily A member 5 protein, from Mouse, contains 602 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient, The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:8226976, PubMed:11349004), Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity), Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity), Homotetrameric channels display rapid activation and slow inactivation (PubMed:8226976, PubMed:11349004), May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity)

Belongs to the potassium channel family, A (Shaker) (TC 1,A,1,2) subfamily, Kv1,5/KCNA5 sub-subfamily


This is Programmed cell death protein 4 protein, from Mouse, contains 469 amino acids, locates in Cytoplasm.

Inhibits translation initiation and cap-dependent translation, May excert its function by hindering the interaction between EIF4A1 and EIF4G, Inhibits the helicase activity of EIF4A, Modulates the activation of JUN kinase, Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription, May play a role in apoptosis, Tumor suppressor, Inhibits tumor promoter-induced neoplastic transformation, Binds RNA


This is Meiosis-specific nuclear structural protein 1 protein, from Mouse, contains 491 amino acids, locates in Nucleus.

May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis, Required for sperm flagella assembly (PubMed:22396656), May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC), ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules (By similarity)


This is Astrocytic phosphoprotein PEA-15 protein, from Mouse, contains 130 amino acids, is soluble, locates in Cytoplasm.

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade, Inhibits RPS6KA3 activities by retaining it in the cytoplasm, Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis, Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity)


This is ATP-dependent RNA helicase DDX3Y protein, from Mouse, contains 658 amino acids, locates in Cytoplasm.

Probable ATP-dependent RNA helicase, During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (PubMed:30475900)

Belongs to the DEAD box helicase family, DDX3/DED1 subfamily


This is Semaphorin-4A protein, from Mouse, contains 760 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:20043131, PubMed:17318185), Regulates glutamatergic and GABAergic synapse development (PubMed:29981480), Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480), Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988), Promotes phosphorylation of TIMD2 (PubMed:12374982), Inhibits angiogenesis (PubMed:17318185), Promotes axon growth cone collapse (PubMed:20043131), Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131)


This is Transcription termination factor 1 protein, from Mouse, contains 859 amino acids, locates in Nucleus.

Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin (PubMed:7720715, PubMed:9267035, PubMed:15292447, PubMed:9049305), Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription (PubMed:15292447, PubMed:20513429), Interaction with BAZ2A/TIP5 recovers DNA-binding activity (PubMed:15292447)


This is Synaptonemal complex protein 1 protein, from Mouse, contains 993 amino acids, locates in Nucleus.

Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase (PubMed:16717126), Required for normal assembly of the central element of the synaptonemal complexes (PubMed:15937223), Required for normal centromere pairing during meiosis (PubMed:22761579), Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility (PubMed:15937223)


This is Homeobox protein SIX2 protein, from Mouse, contains 296 amino acids, locates in Nucleus.

Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach, During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation, Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4, Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1, During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681), During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448), During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982), May also be involved in limb tendon and ligament development (PubMed:7720577), Plays a role in cell proliferation and migration (By similarity)

Belongs to the SIX/Sine oculis homeobox family


This is Transcription intermediary factor 1-beta protein, from Mouse, contains 834 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger, has 1 PHD-type Zinc finger, locates in Nucleus.

RING-type

B box-type

B box-type

PHD-type

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) (PubMed:20164836, PubMed:22110054, PubMed:25247314, PubMed:27658112), Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes, Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression, Recruitment of SETDB1 induces heterochromatinization, May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1, Also a corepressor for ERBB4, Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation, May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1, Important regulator of CDKN1A/p21(CIP1), Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger, Specifically sumoylates IRF7, thereby inhibiting its transactivation activity, Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6, Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors, Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells, Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:20164836), In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (PubMed:20164836), Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing, The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity), Acts as a corepressor for ZFP568 (PubMed:22110054, PubMed:27658112)


This is U1 small nuclear ribonucleoprotein 70 kDa protein, from Mouse, contains 448 amino acids, is soluble, locates in Nucleus.

Truncated isoforms that lack the RRM domain cannot bind U1-snRNA


This is Urea transporter 2 protein, from Rat, contains 929 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the transport of urea driven by a concentration gradient across the cell membrane of the kidney inner medullary collecting duct which is critical to the urinary concentrating mechanism


This is Sodium/nucleoside cotransporter 1 protein, from Rat, contains 648 amino acids, is membrane-bound, locates in Cell membrane.

Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient, Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity, Therefore, exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (PubMed:8027026, PubMed:8967974), Involved in renal nucleoside (re)absorption (By similarity)

Belongs to the concentrative nucleoside transporter (CNT) (TC 2,A,41) family


This is Zinc finger protein 148 protein, from Rat, contains 794 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

Involved in transcriptional regulation, Represses the transcription of a number of genes including gastrin, stromelysin and enolase, Binds to the G-rich box in the enhancer region of these genes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Heterogeneous nuclear ribonucleoprotein M protein, from Rat, contains 690 amino acids, is soluble, locates in Nucleus.

Pre-mRNA binding protein, binds avidly to poly(G) and poly(U) RNA homopolymers, Involved in splicing, Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines


This is Cytoplasmic dynein 1 intermediate chain 2 protein, from Rat, contains 638 amino acids, is soluble, locates in Cytoplasm.

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:11340075), Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:11340075), The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (PubMed:11340075), Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (PubMed:11340075)

Belongs to the dynein intermediate chain family


This is Protein kinase C-binding protein NELL2 protein, from Rat, contains 816 amino acids, is soluble, locates in Extracellular.

Required for neuron survival through the modulation of MAPK pathways (PubMed:12941464), Involved in the regulation of hypothalamic GNRH secretion and the control of puberty


This is Golgi SNAP receptor complex member 1 protein, from Rat, contains 250 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport, It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor, May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14), Participates in docking and fusion stage of ER to cis-Golgi transport, Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi


This is Acid-sensing ion channel 2 protein, from Rat, contains 512 amino acids, is membrane-bound, locates in Cell membrane.

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride, Also permeable for Li(+) and K(+), Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation, Heteromeric channel assembly seems to modulate channel properties

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family, ASIC2 subfamily


This is SH2B adapter protein 1 protein, from Rat, contains 756 amino acids, locates in Cytoplasm.

Adapter protein for several members of the tyrosine kinase receptor family, Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs), In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues, These phosphotyrosines form potential binding sites for other signaling proteins, GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1, In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways, In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2, Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway, Acts as positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity, Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1, For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2, Enhances RET phosphorylation and kinase activity, Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity)


This is ALX homeobox protein 1 protein, from Rat, contains 326 amino acids, locates in Nucleus.

Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931), Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity), Early on in development, it plays a role in forebrain mesenchyme survival (By similarity), May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity)


This is Bile acid-CoA:amino acid N-acyltransferase protein, from Rat, contains 420 amino acids, locates in Peroxisome.

Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12951368, PubMed:624713), More efficient at taurine conjugation of cholyl CoA than glycine conjugation (PubMed:12951368, PubMed:624713), Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity), This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (By similarity), May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (By similarity), In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity)

Belongs to the C/M/P thioester hydrolase family


This is Monocarboxylate transporter 2 protein, from Rat, contains 489 amino acids, is membrane-bound, locates in Cell membrane.

Proton-coupled monocarboxylate symporter, Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:10417314, PubMed:20695846), Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity)

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is Dual specificity tyrosine-phosphorylation-regulated kinase 1A protein, from Rat, contains 763 amino acids, locates in Nucleus.

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:8631952, PubMed:9748265, PubMed:18938227, PubMed:22998443), Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (By similarity), Plays an important role in double-strand breaks (DSBs) repair following DNA damage (By similarity), Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (By similarity), Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity), May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity), Modulates alternative splicing by phosphorylating the splice factor SRSF6 (PubMed:22767602), Has pro-survival function and negatively regulates the apoptotic process, Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1, This in turn inhibits p53/TP53 activity and apoptosis (By similarity), Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (PubMed:18938227)


This is SNF-related serine/threonine-protein kinase protein, from Rat, contains 746 amino acids, locates in Nucleus.

May play a role in hematopoietic cell proliferation or differentiation, Potential mediator of neuronal apoptosis

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family


This is Growth arrest-specific protein 6 protein, from Rat, contains 674 amino acids, is soluble, locates in Extracellular.

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration, GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses (By similarity)


This is Myocyte-specific enhancer factor 2D protein, from Mouse, contains 514 amino acids, locates in Nucleus.

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes, Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival, Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription, Plays a critical role in the regulation of neuronal apoptosis


This is Insulinoma-associated protein 1 protein, from Mouse, contains 521 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 4 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; atypical

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development, Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters, Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner, Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway, Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases, Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism, Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (By similarity), Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex, Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system, Promotes cell cycle signaling arrest and inhibition of cellular proliferation


This is Nuclear receptor subfamily 2 group E member 1 protein, from Mouse, contains 385 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity), Regulates cell cycle progression in neural stem cells of rhe developing brain, Involved in the regulation of retinal development and essential for vision, During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity, May be involved in retinoic acid receptor (RAR) regulation in retinal cells

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Poly(A) RNA polymerase GLD2-A protein, from African clawed frog, contains 509 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail, In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs during oocyte maturation, Plays a central role during oocyte maturation by mediating polyadenylation of dormant mRNAs, which contain 5'AAUAAA-3' sequence in their 3'UTR, In immature oocytes, polyadenylation of poly(A) tails is counteracted by the ribonuclease parn, During maturation parn is excluded from the ribonucleoprotein complex, allowing poly(A) elongation and activation of mRNAs, May not play a role in replication-dependent histone mRNA degradation (By similarity)

Belongs to the DNA polymerase type-B-like family, GLD2 subfamily


This is NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial protein, from Rat, contains 463 amino acids, is membrane-bound, locates in Mitochondrion.

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:30922174), Essential for the catalytic activity of complex I (PubMed:30922174), Essential for the assembly of complex I (By similarity), Redox-sensitive, critical component of the oxygen-sensing pathway in the pulmonary vasculature which plays a key role in acute pulmonary oxygen-sensing and hypoxic pulmonary vasoconstriction (PubMed:30922174), Plays an important role in carotid body sensing of hypoxia (By similarity), Essential for glia-like neural stem and progenitor cell proliferation, differentiation and subsequent oligodendrocyte or neuronal maturation (By similarity)

Belongs to the complex I 49 kDa subunit family


This is 5-hydroxytryptamine receptor 1A protein, from Mouse, contains 421 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various drugs and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways, Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores, Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism, Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior, Plays a role in the response to anxiogenic stimuli

Belongs to the G-protein coupled receptor 1 family, 5-hydroxytryptamine receptor subfamily, HTR1A sub-subfamily


This is Heart- and neural crest derivatives-expressed protein 1 protein, from Mouse, contains 216 amino acids, is soluble, locates in Nucleus.

Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (PubMed:9500551, PubMed:16759287), Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (PubMed:7791788), Acts as a transcriptional repressor of SOX15 (PubMed:16759287), In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity)


This is Interferon-induced protein with tetratricopeptide repeats 1 protein, from Mouse, contains 463 amino acids, is soluble, locates in Cytoplasm.

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs, Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection, Directly binds PPP-RNA in a non-sequence-specific manner, Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism)


This is Neurogenic differentiation factor 1 protein, from Rat, contains 357 amino acids, locates in Cytoplasm.

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3' (By similarity), Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A (By similarity), Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine (By similarity), Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification (By similarity), Also required for dendrite morphogenesis and maintenance in the cerebellar cortex (PubMed:14741104), Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)


This is Dual specificity protein phosphatase 6 protein, from Rat, contains 381 amino acids, is soluble, locates in Cytoplasm.

Inactivates MAP kinases, Has a specificity for the ERK family (PubMed:8626780), Implicated in muscle and neuronal differentiation (PubMed:8631996), Plays an important role in alleviating chronic postoperative pain, Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity), Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily


This is Sarcosine dehydrogenase, mitochondrial protein, from Rat, contains 919 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the last step of the oxidative degradation of choline to glycine, Converts sarcosine into glycine


This is Lysophospholipid acyltransferase LPCAT4 protein, from Human, contains 524 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively, In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity, Prefers long chain acyl-CoAs (C16, C18) as acyl donors

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial protein, from Rat, contains 407 amino acids, is soluble, locates in Mitochondrion.

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2, This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate, Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism, Mediates cellular responses to insulin, Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability, Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation, Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress, Plays a role in p53/TP53-mediated apoptosis

Belongs to the PDK/BCKDK protein kinase family


This is Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 protein, from Rat, contains 887 amino acids, is soluble, locates in Extracellular.

Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:12633853, PubMed:29259743, PubMed:27660691, PubMed:27268273, PubMed:27075612, PubMed:12354767), Major substrate is lysophosphatidylcholine (PubMed:12119361, PubMed:27660691, PubMed:27268273, PubMed:27075612, PubMed:12176993), Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:12119361), Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:12633853, PubMed:27268273), Involved in several motility-related processes such as angiogenesis and neurite outgrowth, Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation, Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein, May have a role in induction of parturition, Possible involvement in cell proliferation and adipose tissue development, Tumor cell motility-stimulating factor (By similarity), Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity), Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity)

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family


This is All-trans-retinol 13,14-reductase protein, from Mouse, contains 609 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the saturation of all-trans-retinol to all-trans-13,14-dihydroretinol (PubMed:15358783, PubMed:17253779, PubMed:19139408), Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers (PubMed:15358783), May play a role in the metabolism of vitamin A (PubMed:15358783, PubMed:17253779), Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP (PubMed:28855500), Required for adipocyte differentiation in a 3T3-L1 cell culture model (PubMed:19139408), This effect seems not to mimic the in vivo situation in which animals show increased adiposity in the absence of RETSAT (PubMed:19940255)

Belongs to the carotenoid/retinoid oxidoreductase family, CrtISO subfamily


This is Flap endonuclease GEN-like 1 protein, from Rice, contains 629 amino acids, locates in Nucleus.

Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA, Possesses both single-stranded and double-stranded DNA-binding activities, Involved in early microspore development, but does not alter meiosis or tapetal cells development (PubMed:15792960, PubMed:22247560), Possesses Holliday junction (HJ) resolvase activity in vitro, Cleaves HJ at symmetrically related sites of the branch point (PubMed:22247560)

Belongs to the XPG/RAD2 endonuclease family, GEN subfamily


This is Solanesyl-diphosphate synthase 1, mitochondrial protein, from Rice, contains 430 amino acids, locates in Mitochondrion.

Involved in the supply of solanesyl diphosphate for ubiquinone-9 (UQ-9) biosynthesis in mitochondria, Farnesyl diphosphate is the preferred substrate


This is Little elongation complex subunit 2 protein, from Human, contains 982 amino acids, locates in Nucleus.

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III


This is Protein REDUCED WALL ACETYLATION 3 protein, from Mouse-ear cress, contains 540 amino acids, is membrane-bound, locates in Golgi apparatus.

Probable O-acetyltransferase involved in the acetylation of xylan during secondary wall biosynthesis

Belongs to the PC-esterase family, CASD1 subfamily


This is Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 protein, from Mouse, contains 193 amino acids, is membrane-bound, locates in Mitochondrion.

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (PubMed:21641550, PubMed:21730175), PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed:21641550), Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity), Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity), Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity), May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (By similarity)


This is PDZ and LIM domain protein 3 protein, from Rat, contains 362 amino acids, is soluble, locates in Cytoplasm.

May play a role in the organization of actin filament arrays within muscle cells


This is Thymocyte selection-associated high mobility group box protein TOX protein, from Mouse, contains 526 amino acids, locates in Nucleus.

Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis (PubMed:25527292, PubMed:20818394, PubMed:11850626, PubMed:18195075, PubMed:15078895, PubMed:25915732), Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA (PubMed:25527292, PubMed:31207603, PubMed:31207604), During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors, Beyond progenitor cells, promotes neurite outgrowth in newborn neurons migrating to reach the cortical plate, May activate or repress critical genes for neural stem cell fate such as SOX2, EOMES and ROBO2 (PubMed:25527292), Plays an essential role in the development of lymphoid tissue-inducer (LTi) cells, a subset necessary for the formation of secondary lymphoid organs: peripheral lymph nodes and Peyer's patches (PubMed:20818394), Acts as a developmental checkpoint and regulates thymocyte positive selection toward T cell lineage commitment (PubMed:11850626, PubMed:18195075), Required for the development of various T cell subsets, including CD4-positive helper T cells, CD8-positive cytotoxic T cells, regulatory T cells and CD1D-dependent natural killer T (NKT) cells (PubMed:18195075, PubMed:15078895), Required for the differentiation of common lymphoid progenitors (CMP) to innate lymphoid cells (ILC), May regulate the NOTCH-mediated gene program, promoting differentiation of the ILC lineage (PubMed:25915732), Required at the progenitor phase of NK cell development in the bone marrow to specify NK cell lineage commitment (PubMed:20818394), Upon chronic antigen stimulation, diverts T cell development by promoting the generation of exhaustive T cells, while suppressing effector and memory T cell programming, May regulate the expression of genes encoding inhibitory receptors such as PDCD1 and induce the exhaustion program, to prevent the overstimulation of T cells and activation-induced cell death (PubMed:31207603, PubMed:31207604)

Belongs to the high motility group (HMG) box superfamily


This is ADP-ribosylation factor-like protein 6-interacting protein 4 protein, from Human, contains 237 amino acids, locates in Nucleus.

Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site, In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA


This is Protein Wnt-11 protein, from African clawed frog, contains 352 amino acids, is soluble, locates in Extracellular.

Ligand for members of the frizzled family of seven transmembrane receptors (By similarity), Shares much functionality with wnt11b, Signals through a non-canonical Wnt pathway to activate Jun-N-terminal kinase (JNK) to regulate gastrulation movements, Acts in a non-cell-autonomous manner to control neural crest migration, probably acting as an extracellular signal from surrounding tissue, but is not required for neural crest induction, Acts redundantly with wnt11b during pronephros induction, Regulates cardiac morphogenesis through the activation of JNK, but is not required for cardiac differentiation, Essential for dorsal fin development; required for an epithelial to mesenchymal transformation event prior to migration of cells into the fin, and ultimately for maintenance of fin structure, Mediates dorsal fin development through a non-canonical pathway mediated by Ca(2+)


This is PDZ and LIM domain protein 7 protein, from Chicken, contains 416 amino acids, is soluble, locates in Cytoplasm.

May function as a scaffold on which the coordinated assembly of proteins can occur, May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues, May be involved in bone formation (By similarity)


This is Tubulin-folding cofactor B protein, from Mouse-ear cress, contains 243 amino acids, is soluble, locates in Cytoplasm.

Involved in control of cell division, Regulates probably the availability of alpha-tubulin for dimerization of alpha-/beta-tubulin, which is required for proper microtubule biogenesis, Decreased expression of TFCB results in enlarged mesophyll cells and leaf epidermal cells with bulged nuclei, increased ploidy and increased numbers of spindles and phragmoplasts


This is Proteinaceous RNase P 2 protein, from Mouse-ear cress, contains 528 amino acids, locates in Nucleus.

Endonuclease RNase P responsible for the 5' maturation of tRNA precursors (PubMed:22549728, PubMed:26655022), Preferentially binds precursor tRNAs containing short 5' leaders and 3' trailers (PubMed:26655022), Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA) (PubMed:22549728)


This is E3 ubiquitin-protein ligase ORTHRUS 5 protein, from Mouse-ear cress, contains 623 amino acids, has 1 PHD-type Zinc finger, has 2 RING-type Zinc finger, locates in Nucleus.

PHD-type

RING-type

RING-type

E3 ubiquitin-protein ligase, Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing, Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11


This is Glutathione hydrolase 2 protein, from Mouse-ear cress, contains 578 amino acids, is soluble, locates in Extracellular.

May be required for glutathione transport into developing seeds

Belongs to the gamma-glutamyltransferase family


This is Nuclear GTPase SLIP-GC protein, from Human, contains 796 amino acids, locates in Nucleus.

Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146), Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity)


This is Acyl-coenzyme A synthetase ACSM2B, mitochondrial protein, from Human, contains 577 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065, PubMed:12616642), Capable of activating medium-chain fatty acids (e,g, butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e,g, benzoate (PubMed:10434065, PubMed:12616642)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Heparan-alpha-glucosaminide N-acetyltransferase protein, from Human, contains 663 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase


This is Natural cytotoxicity triggering receptor 3 ligand 1 protein, from Human, contains 454 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C1-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like C1-type

Triggers NCR3-dependent natural killer cell activation


This is Male-specific lethal 1 homolog protein, from Human, contains 614 amino acids, locates in Nucleus.

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure (PubMed:16227571), Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816), This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816), In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026)


This is Dual specificity phosphatase 29 protein, from Human, contains 220 amino acids, is soluble, locates in Cytoplasm.

Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (PubMed:17498703), Involved in the modulation of intracellular signaling cascades, In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (By similarity), Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity)


This is SPX domain-containing protein 1 protein, from Rice, contains 295 amino acids, locates in Nucleus.

Involved in plant adaptation to phosphate (Pi) starvation (PubMed:19000161), Inhibits PHR2 DNA-binding activity via a Pi-dependent protein interaction (PubMed:25271318), Suppresses the regulation on expression of PT2 by PHR2 and accumulation of shoot Pi (PubMed:20149131), Optimizes growth under phosphate-limited conditions through a negative feedback loop of the PSI (phosphate starvation-induced) signaling pathway (PubMed:19000161, PubMed:20149131), Regulates the expression of SPX2, SPX3 and SPX5 (PubMed:19566645), May be an important link between signal transduction pathways related to phosphate starvation and cold stress (PubMed:19000161), Together with SPX2, plays a negative role in the regulation of leaf inclination by preventing RLI1 transcription factor activity in Pi depleted conditions (PubMed:29610209)


This is GTP diphosphokinase CRSH1, chloroplastic protein, from Rice, contains 583 amino acids, locates in Plastid.

Possesses calcium-dependent ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E,coli relA mutants, May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses


This is Mitochondrial sodium/calcium exchanger protein protein, from Rat, contains 585 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion, Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity), Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses, Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (By similarity), Involved in B-lymphocyte chemotaxis (By similarity), Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange, In contrast to other members of the family its function is independent of K(+) (By similarity)

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family, SLC24A subfamily


This is PDZ and LIM domain protein 2 protein, from Rat, contains 349 amino acids, is soluble, locates in Cytoplasm.

Probable adapter protein located at the actin cytoskeleton that promotes cell attachment, Necessary for the migratory capacity of epithelial cells, Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth, May contribute to tumor cell migratory capacity (By similarity)


This is Meiotic recombination protein REC8 homolog protein, from Rat, contains 593 amino acids, locates in Nucleus.

Required during meiosis for separation of sister chromatids and homologous chromosomes, Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity)


This is Prolyl hydroxylase EGLN2 protein, from Rat, contains 415 amino acids, locates in Nucleus.

Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:15925519), Target proteins are preferentially recognized via a LXXLAP motif (By similarity), Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:15925519), Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (By similarity), Also hydroxylates HIF2A (By similarity), Has a preference for the CODD site for both HIF1A and HIF2A (By similarity), Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (By similarity), Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (By similarity), EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (By similarity), Also regulates susceptibility to normoxic oxidative neuronal death (By similarity), Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (By similarity), Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (By similarity), Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity)


This is E3 SUMO-protein ligase PIAS2 protein, from Rat, contains 572 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied, However, it seems to be mostly involved in gene silencing, Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity (By similarity), Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity)


This is Dual specificity protein phosphatase 13 isoform A protein, from Human, contains 188 amino acids, is soluble, locates in Cytoplasm.

Probable protein tyrosine phosphatase, Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959), Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1, Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1


This is Non-structural maintenance of chromosome element 4 protein, from Fission yeast, contains 300 amino acids, locates in Nucleus.

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks, Plays a critical role in meiosis


This is 2-methylcitrate dehydratase, mitochondrial protein, from Yeast, contains 520 amino acids, locates in Mitochondrion.

Component of the methylcitrate cycle that catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate, The methylcitrate cycle is a metabolic pathway for the consumption of propionic acid


This is 2-methylcitrate synthase, mitochondrial protein, from Yeast, contains 465 amino acids, is soluble, locates in Mitochondrion.

Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate, Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism, Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate


This is DNA-directed RNA polymerases IV and V subunit 4 protein, from Mouse-ear cress, contains 205 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerases IV and V which mediate short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of endogenous repeated sequences, including transposable elements, Required for the de novo DNA methylation directed by the RdDM pathway

Belongs to the eukaryotic RPB4 RNA polymerase subunit family


This is AT-hook motif nuclear-localized protein 25 protein, from Mouse-ear cress, contains 299 amino acids, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity), Binds the DNA sequence GNFEI (GA-negative feedback element I) in the GA3OX1 promoter, Binding to GNFEI sequence is required for GA-negative feedback regulation of GA3OX1


This is Atlastin-3 protein, from Human, contains 541 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes, Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, GB1 subfamily


This is Poly(A) RNA polymerase GLD2-B protein, from African clawed frog, contains 509 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail, In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs during oocyte maturation, Plays a central role during oocyte maturation by mediating polyadenylation of dormant mRNAs, which contain 5'AAUAAA-3' sequence in their 3'-UTR, In immature oocytes, polyadenylation of poly(A) tails is counteracted by the ribonuclease parn, During maturation parn is excluded from the ribonucleoprotein complex, allowing poly(A) elongation and activation of mRNAs, May not play a role in replication-dependent histone mRNA degradation (By similarity)


This is Homeobox protein orthopedia B protein, from Zebrafish, contains 315 amino acids, locates in Nucleus.

Involved in the specification of isotocin cells, Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum

Belongs to the paired homeobox family, Bicoid subfamily


This is LEM domain-containing protein 2 protein, from Mouse, contains 511 amino acids, is membrane-bound, locates in Nucleus.

Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization and maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967), Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (By similarity), Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (By similarity), During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (By similarity), Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (PubMed:36377660), Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT (PubMed:25790465), Required for myoblast differentiation involving regulation of ERK signaling (PubMed:17062158, PubMed:19720741), Essential for cardiac homeostasis and proper heart function (PubMed:36377660)


This is Dermokine protein, from Human, contains 476 amino acids, is soluble, locates in Extracellular.

May act as a soluble regulator of keratinocyte differentiation


This is Acyl-CoA wax alcohol acyltransferase 2 protein, from Human, contains 333 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705), Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038), Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that catalyzes 11-cis-specific retinyl ester synthesis (PubMed:16106050, PubMed:24799687), Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687)

Belongs to the diacylglycerol acyltransferase family


This is BTB/POZ and TAZ domain-containing protein 5 protein, from Mouse-ear cress, contains 368 amino acids, has 1 TAZ-type Zinc finger, is soluble, locates in Cytoplasm.

TAZ-type

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins


This is GDP-fucose protein O-fucosyltransferase 1 protein, from Rat, contains 395 amino acids, locates in Endoplasmic reticulum.

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines, Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer, Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs) (By similarity), Plays a crucial role in NOTCH signaling, Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats, This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1

Belongs to the glycosyltransferase 65 family


This is Secreted frizzled-related protein 4 protein, from Human, contains 346 amino acids, is soluble, locates in Extracellular.

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts, They have a role in regulating cell growth and differentiation in specific cell types (By similarity), SFRP4 plays a role in bone morphogenesis, May also act as a regulator of adult uterine morphology and function, May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity), Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927)

Belongs to the secreted frizzled-related protein (sFRP) family


This is Ciliogenesis and planar polarity effector 2 protein, from African clawed frog, contains 249 amino acids, is soluble, locates in Cytoplasm.

Potential effector of the planar cell polarity signaling pathway, Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes, Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia, More generally involved in exocytosis in secretory cells

Belongs to the small GTPase superfamily, Rab family


This is Leukocyte-associated immunoglobulin-like receptor 1 protein, from Human, contains 287 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells, Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11, It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation, May also play its inhibitory role independently of SH2-containing phosphatases, Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta, Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion, Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells, Inhibits the differentiation of peripheral blood precursors towards dendritic cells


This is Glycine N-acyltransferase protein, from Human, contains 296 amino acids, locates in Mitochondrion.

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently, Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors, Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid

Belongs to the glycine N-acyltransferase family


This is Condensin-2 complex subunit H2 protein, from Human, contains 605 amino acids, locates in Nucleus.

Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007), May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids, Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation, Required for decatenation of chromatin bridges at anaphase, Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity), Seems to have lineage-specific role in T-cell development (PubMed:14532007)

Belongs to the CND2 H2 (condensin-2 subunit 2) family


This is Protein SPEAR3 protein, from Mouse-ear cress, contains 193 amino acids, locates in Nucleus.

Transcriptional regulator of leaf development, Acts as an adapter-like transcriptional repressor recruiting TPL/TPR corepressors to inhibit the CIN-like TCP transcription factors (PubMed:23444332)


This is U11/U12 small nuclear ribonucleoprotein 48 kDa protein protein, from Human, contains 339 amino acids, has 1 CHHC U11-48K-type Zinc finger, locates in Nucleus.

CHHC U11-48K-type

Likely involved in U12-type 5' splice site recognition


This is Aldose reductase A protein, from Social amoeba, contains 297 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies (PubMed:14551196), Probably affects several metabolic pathways in addition to converting glucose to sorbitol (PubMed:14551196), Affects group size (PubMed:14551196)

Belongs to the aldo/keto reductase family


This is rRNA methyltransferase 1, mitochondrial protein, from Human, contains 353 amino acids, locates in Mitochondrion.

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA

Belongs to the class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase TrmH family


This is Replication protein A 32 kDa subunit-A protein, from African clawed frog, contains 276 amino acids, locates in Nucleus.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism, Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage

Belongs to the replication factor A protein 2 family


This is Centromere protein P protein, from Human, contains 288 amino acids, locates in Nucleus.

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation, May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex


This is Grainyhead-like protein 2 homolog protein, from Human, contains 625 amino acids, is membrane-bound, locates in Nucleus.

Transcription factor playing an important role in primary neurulation and in epithelial development (PubMed:29309642, PubMed:25152456), Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (By similarity), During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation, Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity), Regulates epithelial morphogenesis acting as a target gene-associated transcriptional activator of apical junctional complex components, Up-regulates of CLDN3 and CLDN4, as well as of RAB25, which increases the CLDN4 protein and its localization at tight junctions (By similarity), Comprises an essential component of the transcriptional machinery that establishes appropriate expression levels of CLDN4 and CDH1 in different types of epithelia, Exhibits functional redundancy with GRHL3 in epidermal morphogenetic events and epidermal wound repair (By similarity), In lung, forms a regulatory loop with NKX2-1 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity), In keratinocytes, plays a role in telomerase activation during cellular proliferation, regulates TERT expression by binding to TERT promoter region and inhibiting DNA methylation at the 5'-CpG island, possibly by interfering with DNMT1 enzyme activity (PubMed:19015635, PubMed:20938050), In addition, impairs keratinocyte differentiation and epidermal function by inhibiting the expression of genes clustered at the epidermal differentiation complex (EDC) as well as GRHL1 and GRHL3 through epigenetic mechanisms (PubMed:23254293)

Belongs to the grh/CP2 family, Grainyhead subfamily


This is Mitochondrial sodium/calcium exchanger protein protein, from Human, contains 584 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928), Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity), Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385), Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928), Involved in B-lymphocyte chemotaxis (By similarity), Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069), In contrast to other members of the family its function is independent of K(+) (PubMed:15060069)


This is Amoebiasin-1 protein, from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM), contains 102 amino acids, is soluble, locates in Cytoplasm.

Cysteine protease inhibitor (PubMed:15757643, PubMed:16979632, PubMed:21440496, PubMed:32731033), Inhibits cysteine proteases CP1, CP2 and CP5 (PubMed:16979632), May protect the cytosol against cysteine proteases released by damaged intracellular vesicles (Probable)

Belongs to the protease inhibitor I42 family


This is Growth/differentiation factor 6 protein, from Human, contains 455 amino acids, is soluble, locates in Extracellular.

Growth factor that controls proliferation and cellular differentiation in the retina and bone formation, Plays a key role in regulating apoptosis during retinal development, Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924), Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton, Plays a key role in establishing boundaries between skeletal elements during development, Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures, Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex, The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732), Also involved in the induction of adipogenesis from mesenchymal stem cells, This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity)


This is DNA mismatch repair protein MSH5 protein, from Rice, contains 809 amino acids, locates in Nucleus.

Involved in meiotic recombination, Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis, Promotes homologous recombination through facilitating chiasma formation during prophase I, Involved in the control of class I crossover (interference-sensitive crossover) formation

Belongs to the DNA mismatch repair MutS family


This is Gibberellin receptor GID1 protein, from Rice, contains 354 amino acids, locates in Nucleus.

Functions as soluble gibberellin (GA) receptor, GA is an essential hormone that regulates growth and development in plants, Binds with high affinity the biologically active GAs such as GA1, GA3 and GA4, but has low or no affinity for the biologically inactive GAs, Upon GA-binding, it interacts with the DELLA protein SLR1, a repressor of GA signaling, This leads to SLR1 degradation by the proteasome, allowing the GA signaling pathway

Belongs to the 'GDXG' lipolytic enzyme family


This is 2',5'-phosphodiesterase 12 protein, from Human, contains 609 amino acids, is soluble, locates in Mitochondrion.

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system, Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709), Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709), Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs), Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709)


This is Proline dehydrogenase 2, mitochondrial protein, from Mouse-ear cress, contains 476 amino acids, locates in Mitochondrion.

Converts proline to delta-1-pyrroline-5-carboxylate


This is Calcium-dependent protein kinase 32 protein, from Mouse-ear cress, contains 538 amino acids, is membrane-bound, locates in Nucleus.

May play a role in signal transduction pathways that involve calcium as a second messenger, Involved in maintaining Ca2+ homeostasis in pollen tube tips by regulating CNGC18 (PubMed:24121288), Functions as regulator of the calcium-mediated abscisic acid (ABA) signaling pathway (PubMed:16299177), Phosphorylates ABA-responsive transcription factor ABF4 in vitro (PubMed:16299177)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDPK subfamily


This is Monofunctional riboflavin biosynthesis protein RIBA 2, chloroplastic protein, from Mouse-ear cress, contains 476 amino acids, locates in Plastid.

Involved in riboflavin biosynthesis, Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate, RIBA2 and RIBA3 together are not able to complement the loss of function of RIBA1

In the C-terminal section; belongs to the GTP cyclohydrolase II family


This is CST complex subunit TEN1 protein, from Mouse-ear cress, contains 127 amino acids, locates in Nucleus.

Required for the maintenance of meristems and stem cells through the reduction of DNA damage (PubMed:21781195), Promotes telomere integrity by maintaining telomere length and proper architecture of the chromosome terminus (PubMed:23572541), Negatively regulates telomerase repeat addition processivity (PubMed:23572541), Hampers contacts between enzymatically active telomerase and CST complex (PubMed:25329641)


This is DNA oxidative demethylase ALKBH2 protein, from Human, contains 261 amino acids, locates in Nucleus.

Dioxygenase that repairs alkylated nucleic acid bases by direct reversal oxidative dealkylation, Can process both double-stranded (ds) and single-stranded (ss) DNA substrates, with a strong preference for dsDNA (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:20714506, PubMed:25797601, PubMed:23972994), Uses molecular oxygen, 2-oxoglutarate and iron as cofactors to oxidize the alkyl groups that are subsequently released as aldehydes, regenerating the undamaged bases, Probes the base pair stability, locates a weakened base pair and flips the damaged base to accommodate the lesion in its active site for efficient catalysis (PubMed:18432238, PubMed:22659876), Repairs monoalkylated bases, specifically N1-methyladenine and N3-methylcytosine, as well as higher order alkyl adducts such as bases modified with exocyclic bridged adducts known as etheno adducts including 1,N6-ethenoadenine, 3,N4-ethenocytosine and 1,N2-ethenoguanine (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:20714506, PubMed:25797601, PubMed:23972994, PubMed:26408825), Acts as a gatekeeper of genomic integrity under alkylation stress, Efficiently repairs alkylated lesions in ribosomal DNA (rDNA), These lesions can cause ss- and dsDNA strand breaks that severely impair rDNA transcription (PubMed:23972994), In a response mechanism to DNA damage, associates with PCNA at replication forks to repair alkylated adducts prior to replication (PubMed:19736315, PubMed:26408825)


This is Chondroadherin-like protein protein, from Human, contains 762 amino acids, is soluble, locates in Extracellular.

Potential negative modulator of chondrocyte differentiation, Inhibits collagen fibrillogenesis in vitro, May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment

Belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily


This is Serine/threonine-protein phosphatase 4 regulatory subunit 4 protein, from Human, contains 873 amino acids, is soluble, locates in Cytoplasm.

Putative regulatory subunit of serine/threonine-protein phosphatase 4


This is Transmembrane protein 214 protein, from Human, contains 689 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis, Required or the activation of CASP4 following endoplasmic reticulum stress


This is Epithelial splicing regulatory protein 1 protein, from Human, contains 681 amino acids, locates in Nucleus.

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms, Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT), Acts by directly binding specific sequences in mRNAs, Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943), Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity)


This is Vasculin protein, from Mouse, contains 473 amino acids, locates in Nucleus.

Functions as a GC-rich promoter-specific transactivating transcription factor


This is Inactive dipeptidyl peptidase 10 protein, from Mouse, contains 797 amino acids, is membrane-bound, locates in Cell membrane.

Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982), Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:22311982), Has no dipeptidyl aminopeptidase activity (Probable)

Belongs to the peptidase S9B family, DPPIV subfamily


This is RNA polymerase-associated protein LEO1 protein, from Zebrafish, contains 696 amino acids, locates in Nucleus.

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II, PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity), PAF1C seems to be required for multiple steps in cardiac formation, Involved in heart development and required for differentiation of the atrioventricular boundary, Required for neural crest cell development


This is Fanconi anemia core complex-associated protein 20 protein, from Human, contains 180 amino acids, has 1 UBZ2-type Zinc finger, locates in Nucleus.

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair, Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex, Promotes translesion synthesis via interaction with REV1


This is Zinc finger CCHC domain-containing protein 8 protein, from Human, contains 707 amino acids, has 1 CCHC-type Zinc finger, is soluble, locates in Nucleus.

CCHC-type

Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484), NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation, May be involved in pre-mRNA splicing (Probable), It is required for 3'-end maturation of telomerase RNA component (TERC), TERC 3'-end targeting to the nuclear RNA exosome, and for telomerase function (PubMed:31488579)


This is Ubiquitin-conjugating enzyme E2 J2 protein, from Mouse, contains 259 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells, The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage

Belongs to the ubiquitin-conjugating enzyme family


This is Endoplasmic reticulum aminopeptidase 2 protein, from Human, contains 960 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides, Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules, Preferentially hydrolyzes the basic residues Arg and Lys


This is Lysophospholipid acyltransferase 5 protein, from Human, contains 487 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18782225, PubMed:18195019, PubMed:18772128), Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids, Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18782225, PubMed:18195019, PubMed:18772128), Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128), Has higher activity for LPC acyl acceptors compared to LPEs and LPSs, Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity), Acts as a major LPC O-acyltransferase in liver and intestine, As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles, Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity), Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation, Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity), In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake, Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity), In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity)

Belongs to the membrane-bound acyltransferase family


This is Parafibromin protein, from Human, contains 531 amino acids, locates in Nucleus.

Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways, May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression, Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency, PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1, PAF1C is required for transcription of Hox and Wnt target genes, PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL, PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3), PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription, PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors, In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription, Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling, Involved in polyadenylation of mRNA precursors


This is Polyamine-modulated factor 1 protein, from Human, contains 205 amino acids, locates in Nucleus.

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis, May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT


This is LETM1 domain-containing protein 1 protein, from Human, contains 360 amino acids, is membrane-bound, locates in Mitochondrion.

Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes, In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity), May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577), Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013)