This is Synaptonemal complex central element protein 2 protein, from Mouse, contains 171 amino acids, locates in Nucleus.

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:15944401), Requires SYCP1 in order to be incorporated into the central element (PubMed:15944401, PubMed:16968740), May have a role in the synaptonemal complex assembly, stabilization and recombination (PubMed:15944401)


This is Isoprene synthase, chloroplastic protein, from White poplar, contains 595 amino acids, locates in Plastid.

Lyase that catalyzes the formation of isoprene from dimethylallyl diphosphate, but not from isopentenyl diphosphate or geranyl diphosphate

Belongs to the terpene synthase family, Tpsb subfamily


This is Cell-cell adhesion glycoprotein 64 protein, from Cellular slime mold, contains 320 amino acids, is membrane-bound, locates in Cell membrane.


This is Nudix hydrolase 13, mitochondrial protein, from Mouse-ear cress, contains 202 amino acids, locates in Mitochondrion.

Mediates the hydrolysis of some nucleoside diphosphate derivatives, Can use diadenosine 5',5'''-P(1)P(6) hexaphosphate (Ap(6)A), diadenosine 5',5'''-P(1)P(5) pentaphosphate (Ap(5)A) and adenosine tetraphosphate (p(4)A) as substrates, but not diadenosine 5',5'''-P(1)P(4) tetraphosphate (Ap(4)A), diadenosine 5',5'''-P(1)P(3) triphosphate (Ap(3)A), deoxyribonucleoside triphosphates, ribonucleoside triphosphates, diphosphoinositol pentakisphosphate (PP-InsP(5)) and 5-phospho-alpha-D-ribosyl diphosphate (PRPP)


This is Alpha-elapitoxin-Oh3a protein, from King cobra, contains 93 amino acids, is soluble, locates in Extracellular.

Binds to muscular and neuronal nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:35341214), Pseudo-irreversibly inhibits twitches in chick biventer cervicis nerve-muscle preparations in a concentration-dependent manner (PubMed:35341214)

Belongs to the snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily


This is Glycerol-3-phosphate acyltransferase 3 protein, from Human, contains 434 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135), Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427), Protects cells against lipotoxicity (PubMed:30846318)

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is Metallophosphoesterase 1 protein, from Human, contains 396 amino acids, is membrane-bound, locates in Golgi apparatus.

Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi, Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins

Belongs to the metallophosphoesterase superfamily, MPPE1 family


This is ORM1-like protein 2 protein, from Human, contains 153 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Negative regulator of sphingolipid synthesis


This is PDZ and LIM domain protein 3 protein, from Human, contains 364 amino acids, is soluble, locates in Cytoplasm.

May play a role in the organization of actin filament arrays within muscle cells


This is Very-long-chain 3-oxoacyl-CoA reductase protein, from Human, contains 312 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle, This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle, This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation, Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators, May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation

Belongs to the short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily


This is mRNA export factor GLE1 protein, from Human, contains 698 amino acids, locates in Cytoplasm.

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm, May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC)


This is U4/U6.U5 tri-snRNP-associated protein 2 protein, from Human, contains 565 amino acids, has 1 UBP-type; degenerate Zinc finger, locates in Nucleus.

UBP-type; degenerate

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367), Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint, Does not have ubiquitin-specific peptidase activity (PubMed:18728397)


This is Kelch-like protein 22 protein, from Human, contains 634 amino acids, is soluble, locates in Cytoplasm.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores, The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation, Monoubiquitination of PLK1 does not lead to PLK1 degradation (PubMed:19995937, PubMed:23455478), The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5, Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway, It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy (PubMed:29769719)


This is Acylglycerol kinase, mitochondrial protein, from Human, contains 422 amino acids, is membrane-bound, locates in Mitochondrion.

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15939762), Does not phosphorylate sphingosine (PubMed:15939762), Phosphorylates ceramide (By similarity), Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity), Independently of its lipid kinase activity, acts as a component of the TIM22 complex (PubMed:28712724, PubMed:28712726), The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724, PubMed:28712726), In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (PubMed:28712724), Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (PubMed:15939762)


This is Histone-lysine N-methyltransferase SETMAR protein, from Human, contains 684 amino acids, locates in Nucleus.

Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration, DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions, Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842), In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3, Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448), Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750)

In the C-terminal section; belongs to the mariner transposase family


This is Akirin-2 protein, from Human, contains 203 amino acids, locates in Nucleus.

Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (PubMed:34711951), Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (PubMed:34711951), Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6 (By similarity), Also involved in adaptive immunity by promoting B-cell activation (By similarity), Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells (By similarity), Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors (By similarity), Also plays a role in facilitating interdigital tissue regression during limb development (By similarity)


This is Pyrroline-5-carboxylate reductase 3 protein, from Human, contains 274 amino acids, is soluble, locates in Cytoplasm.

Enzyme that catalyzes the last step in proline biosynthesis, Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs), PYCRL is exclusively linked to the conversion of ornithine to proline

Belongs to the pyrroline-5-carboxylate reductase family


This is Single-strand selective monofunctional uracil DNA glycosylase protein, from Human, contains 270 amino acids, locates in Nucleus.

Recognizes base lesions in the genome and initiates base excision DNA repair, Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates, The activity is greater toward mismatches (U/G) compared to matches (U/A), Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases, The activity is damage-specific and salt-dependent, The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration

Belongs to the uracil-DNA glycosylase (UDG) superfamily, SMUG1 family


This is Protein disulfide isomerase-like 1-1 protein, from Rice, contains 512 amino acids, is soluble, locates in Endoplasmic reticulum.

Probable protein disulfide isomerase that plays an essential role in the segregation of proglutelin and prolamin polypeptides within the ER lumen of endosperm, Required to retain proglutelin in the cisternal ER lumen until ER export and, thereby, indirectly prevents heterotypic interactions with prolamin polypeptides

Belongs to the protein disulfide isomerase family


This is BolA-like protein 3 protein, from Human, contains 107 amino acids, is soluble, locates in Extracellular.

Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins, Probably acts together with NFU1 (PubMed:27532772)


This is Leucine-rich repeat protein lrrA protein, from Social amoeba, contains 510 amino acids, is soluble, locates in Cytoplasm.

Involved in cytoskeleton remodeling, which is needed for normal chemotactic aggregation and efficient cell sorting during multicellular morphogenesis


This is Cortexillin-1 protein, from Social amoeba, contains 444 amino acids, is soluble, locates in Cytoplasm.

Actin-bundling protein, When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks, Plays a major role in cytokinesis, Negatively regulates cortical localization of rapgap1


This is Lamin-like protein protein, from Social amoeba, contains 716 amino acids, is membrane-bound, locates in Nucleus.

Component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, Helps to maintain integrity of nuclear structures in response to mechanical stress

Belongs to the intermediate filament family


This is LIM domain-containing protein B protein, from Social amoeba, contains 553 amino acids, is soluble, locates in Cytoplasm.

Regulates and controls rearrangements of the actin cytoskeleton, Required for tip formation, morphogenesis, cell adhesion and motility, chemotaxis and aggregates formation, May function downstream of paxB


This is Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial protein, from Social amoeba, contains 484 amino acids, locates in Mitochondrion.

Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:16507593, PubMed:20406883), Acts as an arginine methyltransferase and probably acts by mediating arginine methylation of ndufs2 (By similarity)


This is Peptidyl-prolyl cis-trans isomerase A protein, from Social amoeba, contains 179 amino acids, is soluble, locates in Cytoplasm.

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding

Belongs to the cyclophilin-type PPIase family


This is Counting factor associated protein D protein, from Social amoeba, contains 531 amino acids, is soluble, locates in Extracellular.

Inhibitor that slows proliferation of secreting cells (also known as chalone), Requires aprA for activity


This is Serine/threonine-protein phosphatase 2A regulatory subunit psrA protein, from Social amoeba, contains 628 amino acids, is soluble, locates in Cytoplasm.

Involved in developmental cell fate decision

Belongs to the phosphatase 2A regulatory subunit B56 family


This is CAR1 transcription factor protein, from Social amoeba, contains 876 amino acids, locates in Nucleus.

Nuclear transcription factor with zinc-dependent sequence binding specificity, Required for carA-1 and carA-2 expression in early development, Also required throughout later developmental stages - where it has a cell-autonomous role that is distinct from its capacity to control carA-1 and carA-2 expression, Required for terminal spore differentiation but not essential for cell differentiation and cell sorting, May function to help insulate distinct pathways from simultaneous and universal activation by cAMP


This is Sun domain-containing protein 1 protein, from Social amoeba, contains 905 amino acids, is membrane-bound, locates in Nucleus.

May have an important role in defining the spacing of the nuclear envelope lumen, Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability, Requires direct chromatin binding for inner nuclear membrane targeting


This is Catalase-B protein, from Social amoeba, contains 692 amino acids, is soluble, locates in Cytoplasm.

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide, Its accumulation in prespore cells affords the spores protection from oxidation during prolonged dormancy, Required for normal developmental timing, possibly through a regulatory role in differentiation and morphogenesis


This is Small RNA 2'-O-methyltransferase protein, from Zebrafish, contains 402 amino acids, is soluble, locates in Cytoplasm.

Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements, This probably protects the 3'-end of piRNAs from uridylation and adenylation activities and subsequent degradation, Stabilization of piRNAs is essential for oocyte development

Belongs to the methyltransferase superfamily, HEN1 family


This is N-acetyltransferase ESCO2 protein, from Human, contains 601 amino acids, has 1 CCHH-type Zinc finger, locates in Nucleus.

CCHH-type

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495), Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together, In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase, Acetylates the cohesin component SMC3 (PubMed:21111234)

Belongs to the acetyltransferase family, ECO subfamily


This is Venom prothrombin activator pseutarin-C catalytic subunit protein, from Eastern brown snake, contains 467 amino acids, is soluble, locates in Extracellular.

Snake prothrombin activator that attacks the hemostatic system of prey, This non-catalytic subunit is functionally similar to blood coagulation factor V (PubMed:12362232, PubMed:23869089), It serves as a critical cofactor for the prothrombinase activity of the catalytic subunit, which is similar to the blood coagulation factor X (PubMed:12362232, PubMed:23869089), The complex converts prothrombin to thrombin by sequential cleavage at two positions, Arg-320 followed by Arg-271 (PubMed:23869089), Cleavage at Arg-320 produces an active intermediate known as meizothrombin (PubMed:23869089), Meizothrombin is the 'second' substrate for prothrombinase, and it docks in an altered manner to present the second cleavage site (271) (PubMed:23869089), Cleavage at Arg-271 releases active thrombin from its pro-fragment (PubMed:23869089), This order of events is reversed if the protease component of prothrombinase is used on its own, suggesting that the 271 site is inherently more accessible to proteolysis (PubMed:23869089), The complex converts prothrombin to thrombin in presence but also in the absence of membrane (PubMed:23869089)

Belongs to the peptidase S1 family, Snake venom subfamily


This is Histone deacetylase HDT2 protein, from Mouse-ear cress, contains 306 amino acids, locates in Nucleus.

Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events

Belongs to the histone deacetylase HD2 family


This is Mechanosensitive ion channel protein 2, chloroplastic protein, from Mouse-ear cress, contains 673 amino acids, is membrane-bound, locates in Plastid.

Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer (By similarity), Controls plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension, Acts as a component of the chloroplast division machinery


This is DEAD-box ATP-dependent RNA helicase 15 protein, from Mouse-ear cress, contains 427 amino acids, locates in Nucleus.

ATP-dependent RNA helicase involved in pre-mRNA splicing, Required for the export of mRNA out of the nucleus, In addition to ssRNA and dsRNA, binds dsDNA, but not ssDNA

Belongs to the DEAD box helicase family, DECD subfamily


This is Nuclear poly(A) polymerase 3 protein, from Mouse-ear cress, contains 507 amino acids, locates in Nucleus.

Essential protein (PubMed:19956626), Polymerase that creates the 3'-poly(A) tail of mRNA's (PubMed:15297145), Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites, May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity)

Belongs to the poly(A) polymerase family


This is Sodium/hydrogen exchanger 2 protein, from Mouse-ear cress, contains 546 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Acts in low affinity electroneutral exchange of protons for cations such as Na(+) or K(+) across membranes, May also exchange Li(+) and Cs(+) with a lower affinity, Involved in vacuolar ion compartmentalization necessary for cell volume regulation and cytoplasmic Na(+) detoxification

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2,A,36) family


This is Protein MICRORCHIDIA 6 protein, from Mouse-ear cress, contains 663 amino acids, locates in Nucleus.

Involved in RNA-directed DNA methylation (RdDM) as a component of the RdDM machinery and required for gene silencing (PubMed:22560611, PubMed:23675613, PubMed:27171427), Together with SUVH2 and SUVH9, regulates the silencing of some transposable elements (TEs) (PubMed:27171427), Exhibits ATPase activity (PubMed:22560611), May also be involved in the regulation of chromatin architecture/condensation to maintain gene silencing (PubMed:22555433, PubMed:27171427), Binds DNA/RNA in a non-specific manner and exhibits endonuclease activity, Probably involved in DNA repair (By similarity), Positive regulator of defense against the oomycete Hyaloperonospora arabidopsidis (Hpa) (PubMed:27171361)

Belongs to the MORC ATPase protein family


This is Serine--glyoxylate aminotransferase protein, from Mouse-ear cress, contains 401 amino acids, locates in Peroxisome.

Photorespiratory enzyme that catalyzes transamination reactions with multiple substrates, including asparagine, Functions exclusively as a catabolic enzyme in Asn metabolism (PubMed:18235971, PubMed:23098902), Involved in root development during seedling establishment after seed germination by regulating serine homeostasis and acetate conversion (PubMed:31161264)

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family


This is Transcription factor FAMA protein, from Mouse-ear cress, contains 414 amino acids, locates in Nucleus.

Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267), Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519), Together with SPCH and MUTE, regulates the stomata formation, Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors, Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267), Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956)


This is 3-ketoacyl-CoA synthase 10 protein, from Mouse-ear cress, contains 550 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Contributes to cuticular wax and suberin biosynthesis, Prevents the postgenital fusion of epiderm cells in organs in contact, as well as ectopic pollen hydration and germination, Required during ovules formation, May regulate an epidermis-specific developmental program during gynoecial ontogeny

Belongs to the thiolase-like superfamily, Chalcone/stilbene synthases family


This is Protein TRANSPORT INHIBITOR RESPONSE 1 protein, from Mouse-ear cress, contains 594 amino acids, locates in Nucleus.

Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription, The SCF(TIR1) E3 ubiquitin ligase complex is involved in auxin-mediated signaling pathway that regulate root and hypocotyl growth, lateral root formation, cell elongation, and gravitropism, Appears to allow pericycle cells to overcome G2 arrest prior to lateral root development, Plays a role in ethylene signaling in roots, Confers sensitivity to the virulent bacterial pathogen P,syringae


This is ATP-dependent DNA helicase PIF5 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 928 amino acids, locates in Mitochondrion.

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability, Involved in processing of minicircle Okazaki fragments

Belongs to the helicase family, PIF1 subfamily


This is NAD-dependent protein deacylase SIR2rp3 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 244 amino acids, locates in Mitochondrion.

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins, Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo

Belongs to the sirtuin family, Class III subfamily


This is Bromodomain testis-specific protein protein, from Human, contains 947 amino acids, locates in Nucleus.

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802), Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802), In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802), Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity), Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity), Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin


This is Venom prothrombin activator notecarin-D2 protein, from Mainland tiger snake, contains 453 amino acids, is soluble, locates in Extracellular.

Snake prothrombin activator that attacks the hemostatic system of prey, This protein is functionally similar to blood coagulation factor Xa


This is Venom prothrombin activator oscutarin-C catalytic subunit protein, from Coastal taipan, contains 467 amino acids, is soluble, locates in Extracellular.

Snake prothrombin (F2) activator that attacks the hemostatic system of prey, This catalytic subunit is functionally similar to blood coagulation factor Xa, For prothrombin activation, it requires a non-catalytic subunit present in the venom, which is similar to coagulation factor Va, to be fully active, In contrast to the 8 other snake venoms tested, this protein is the only one to also activate factor VII (F7), However, in contrast to prothrombin activation, the factor Va-like subunit is not essential for this activation


This is UTP--glucose-1-phosphate uridylyltransferase protein, from Yeast, contains 500 amino acids, is soluble, locates in Extracellular.

Plays a central role as a glucosyl donor in cellular metabolic pathways


This is Aminopeptidase 2 protein, from Yeast, contains 924 amino acids, is soluble, locates in Extracellular.

Metalloprotease that specifically hydrolyzes peptides with N-terminal alanine, arginine and leucine residues


This is Biofilm regulator 1 protein, from Yeast, contains 422 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Transcription factor required for hyphal growth, biofilm formation, and virulence, Promotes formation of both conventional and pheromone-stimulated biofilms, Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner, Involved in the switch between two heritable states, the white and opaque states, These two cell types differ in many characteristics, including cell structure, mating competence, and virulence, Each state is heritable for many generations, and switching between states occurs stochastically at low frequency


This is Secreted beta-glucosidase SUN41 protein, from Yeast, contains 418 amino acids, is soluble, locates in Extracellular.

Cell surface beta-glucosidase involved in cytokinesis, cell wall biogenesis, adhesion to host tissue, and biofilm formation; thus playing an important role in the host-pathogen interaction, Has hydrolytic activity on linear (1->3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides


This is Cell wall transcription factor ACE2 protein, from Yeast, contains 783 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis, Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1, Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection


This is Stress protein DDR48 protein, from Yeast, contains 212 amino acids, is soluble, locates in Extracellular.

Cell surface protein involved in the ability to sense and respond to changes in the host environment, Required for stress response and confers partial antifungal drug resistance, Contributes to the DNA damage response, Required for the flocculation response stimulated by 3-aminotriazole-induced amino acid starvation


This is Cell surface mannoprotein MP65 protein, from Yeast, contains 378 amino acids, is soluble, locates in Extracellular.

Surface mannoprotein required for hyphal morphogenesis, surface adherence, and pathogenicity, Contributes in a high proportion to the carbohydrate component of the matrix due to high levels of glycosylation and may play important roles during biofilm development and maintenance, Acts as a major antigen target of host cell-mediated immune response, Induces extensive T-cell proliferation of human peripheral blood mononuclear cells, Facilitates host dendritic cells maturation and promotes cytokine production through its glycosylated portion while its protein core is essentially involved in induction of T-cell response

Belongs to the glycosyl hydrolase 17 family


This is Secreted hemophore CSA2 protein, from Yeast, contains 147 amino acids, is soluble, locates in Extracellular.

Secreted heme-binding protein involved in the utilization of iron from human hemoglobin during hyphal growth (PubMed:24796871, PubMed:27617569), May also play a role in non-hemoglobin iron utilization (PubMed:24796871), Heme transfer occurs between PGA7, RBT5 and CSA2 supporting a model in which the 3 CFEM proteins cooperate in a heme-acquisition system and form a cross-cell wall heme-transfer cascade (PubMed:27617569), The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms (PubMed:24796871)


This is Transcription factor SFL1 protein, from Yeast, contains 805 amino acids, locates in Nucleus.

Transcription factor that plays a role of repressor of filamentous growth and flocculation, Antagonizes functions of SFL2 and FLO8, Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia


This is Calcium channel YVC1 protein, from Yeast, contains 675 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Vacuolar calcium channel involved in the release of calcium ions from the vacuole in response to hyperosmotic or alkaline stress, Required for activation of CAP1-related transcription of oxidative stress response (OSR) genes, but also for maintaining the stability of both the mitochondria and the vacuole in a potassium- and calcium-dependent manner, Contributes to pathogenicity, Plays a key role in hyphal polarized growth and re-orientation to host-signals through its contribution to the localization of the Spitzenkoerper to the hyphal tips

Belongs to the transient receptor (TC 1,A,4) family


This is Protein SUR7 protein, from Yeast, contains 270 amino acids, is membrane-bound, locates in Cell membrane.

Involved in cell wall, plasma membrane, and cytoskeletal organization, Plays a role in endocytosis and hyphal morphogenesis, Required to restrict septin proteins to the bud neck and prevents intracellular growth of cell wall, Contributes to secretion, biofilm formation, and macrophage killing, Essential for resistance to stressful conditions and for invasive growth and virulence


This is Transcriptional regulatory protein ASH1 protein, from Yeast, contains 449 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Component of the RPD3C(L) histone deacetylase complex (HDAC), Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity), Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis


This is Chitinase 1 protein, from Yeast, contains 462 amino acids, is soluble, locates in Extracellular.

Chitinase involved in the remodeling of chitin in the fungal cell wall, Plays a role in cell separation

Belongs to the glycosyl hydrolase 18 family, Chitinase class V subfamily


This is Multidrug resistance protein 1 protein, from Yeast, contains 564 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane multidrug efflux pump that confers resistance to numerous chemicals including azoles such as fluconazole, voriconazole, and benztriazoles, as well as to benomyl, cycloheximide, methotrexate, 4-nitroquinoline-N-oxide, sulfometuron methyl, cerulenin, and brefeldin A

Belongs to the major facilitator superfamily, CAR1 family


This is Transcription factor SFL2 protein, from Yeast, contains 714 amino acids, locates in Nucleus.

Transcription factor that plays a role of activator of filamentous growth and which is involved in invasive growth at a high temperature, Required for human oral epithelium colonization and damage, Promotes filamentous growth in EFG1- and FLO8-dependent manners, Antagonizes functions of SFL1


This is White-opaque regulator 1 protein, from Yeast, contains 785 amino acids, locates in Nucleus.

Master transcriptional regulator of the switch between 2 heritable states, the white and opaque states, These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence, Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency, WOR1 Binds the intergenic regions upstream of the genes encoding three additional transcriptional regulators of white-opaque switching, CZF1, EFG1, and WOR2, Phenotypic switching from the white to the opaque phase is a necessary step for mating, Plays a role in cell adhesion and pseudohyphal growth


This is Spore development regulator vosA protein, from Aspergillus nidulans, contains 430 amino acids, locates in Nucleus.

Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:17912349, PubMed:21152013, PubMed:23049895, PubMed:24391470), Controls primarily the late process of sporulation including trehalose biogenesis (PubMed:17912349), The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (PubMed:24391470), The vosA-velB complex binds to the beta-glucan synthase fksA gene promoter in asexual spores for repression (PubMed:25960370)

Belongs to the velvet family, VosA subfamily


This is F-box/LRR-repeat protein 7 protein, from Mouse, contains 491 amino acids, is soluble, locates in Cytoplasm.

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:22306998, PubMed:25778398), During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (PubMed:22306998), It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398)


This is Sodium/hydrogen exchanger 9B2 protein, from Mouse, contains 547 amino acids, is membrane-bound, locates in Mitochondrion.

Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18508966, PubMed:17988971), Uses the proton gradient/membrane potential to extrude sodium (By similarity), Contributes to the regulation of intracellular pH and sodium homeostasis (PubMed:27909897), Also able to mediate Na(+)/Li(+) antiporter activity in kidney (By similarity), May play a physiological role in renal tubular function and blood pressure homeostasis (PubMed:32956652, PubMed:27909897), Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (PubMed:23720317), Involved in sperm motility and fertility (PubMed:27010853), It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (PubMed:20441802, PubMed:17988971)


This is (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial protein, from Peppermint, contains 265 amino acids, locates in Mitochondrion.

Involved in the biosynthesis of menthol and related monoterpenes in leaves, Can use (-)-trans-carveol and, with a lower relative velocity, (-)-trans-isopiperitenol, (+)-neomenthol, (+)-neoisomenthol and (-)-cis-isopiperitenol as substrates, but not (-)-cis-carvenol, (-)-menthol, (+)-isomenthol, 7-hydroxy-limonene, (-)-isopiperitenone or (-)-carvone

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Nucleolar MIF4G domain-containing protein 1 protein, from Human, contains 860 amino acids, locates in Nucleus.

Plays a role in targeting PPP1CA to the nucleolus


This is Ermin protein, from Mouse, contains 281 amino acids, is soluble, locates in Cytoplasm.

Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult, May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)


This is UMP-CMP kinase 2, mitochondrial protein, from Human, contains 449 amino acids, locates in Mitochondrion.

May participate in dUTP and dCTP synthesis in mitochondria, Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor, Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates, May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs, Also displays broad nucleoside diphosphate kinase activity

Belongs to the thymidylate kinase family


This is Probable E3 ubiquitin-protein ligase IRF2BPL protein, from Rat, contains 783 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins, Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway, Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity), Also acts as a transcriptional regulator of genes controlling female reproductive function, May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter


This is Muscular LMNA-interacting protein protein, from Mouse, contains 967 amino acids, locates in Nucleus.

Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (PubMed:33802236), Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1, Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (PubMed:26359501, PubMed:22343712, PubMed:26436652), Binds chromatin (PubMed:33802236), May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (PubMed:22343712), May also repress MYOCD transcriptional activity (PubMed:22343712)


This is Grainyhead-like protein 3 homolog protein, from Mouse, contains 603 amino acids, locates in Nucleus.

Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin, Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes, Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target (PubMed:21081122, PubMed:20654612, PubMed:25347468), Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair (PubMed:21081122), Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury (PubMed:25347468), Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation, Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (PubMed:14608380, PubMed:20654612), Also required for proper development of the oral periderm (PubMed:24360809), No genetic interaction with GRHL1, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122)

Belongs to the grh/CP2 family, Grainyhead subfamily


This is GPI ethanolamine phosphate transferase 2 protein, from Human, contains 983 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Transfers ethanolamine phosphate to the GPI second mannose

Belongs to the PIGG/PIGN/PIGO family, PIGG subfamily


This is Ion channel CASTOR protein, from Lotus corniculatus var. japonicus, contains 853 amino acids, is membrane-bound, locates in Nucleus.

Ion channel with a moderate preference for potassium over sodium and calcium, Involved in perinuclear calcium spiking but not in cytosolic calcium influx, Closed at negative voltages in presence of magnesium, Required for early signal transduction events leading to endosymbiosis, Acts early in a signal transduction chain leading from the perception of Nod factor to the activation of calcium spiking, Also involved in fungal entry into root epidermal cells during the establishment of the arbuscular mycorrhizal symbiosis

Belongs to the castor/pollux (TC 1,A,1,23) family


This is Protein BEX5 protein, from Human, contains 111 amino acids, is soluble, locates in Cytoplasm.


This is DDB1- and CUL4-associated factor 17 protein, from Human, contains 520 amino acids, is membrane-bound, locates in Nucleus.

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex


This is 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial protein, from Human, contains 327 amino acids, is membrane-bound, locates in Mitochondrion.

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

Belongs to the class I-like SAM-binding methyltransferase superfamily, MenG/UbiE family


This is Multidrug and toxin extrusion protein 1 protein, from Rat, contains 566 amino acids, is membrane-bound, locates in Cell membrane.

Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:17047166), Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16928787, PubMed:16850272, PubMed:17047166, PubMed:17582384, PubMed:17327464), Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16928787, PubMed:16850272, PubMed:17047166, PubMed:17582384, PubMed:17327464), May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)

Belongs to the multi antimicrobial extrusion (MATE) (TC 2,A,66,1) family


This is Speedy protein A protein, from Mouse, contains 310 amino acids, locates in Nucleus.

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:15611625), Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation, Interferes with CDKN1B-mediated inhibition of CDK2, Mediates cell survival during the DNA damage process through activation of CDK2 (By similarity)


This is Regulatory protein NPR4 protein, from Mouse-ear cress, contains 574 amino acids, locates in Nucleus.

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity), Involved in the regulation of basal defense responses against pathogens, and may be implicated in the cross-talk between the SA- and JA-dependent signaling pathways


This is Proton-coupled zinc antiporter SLC30A9, mitochondrial protein, from Mouse, contains 567 amino acids, is membrane-bound, locates in Nucleus.

Mitochondrial proton-coupled zinc ion antiporter mediating the export of zinc from the mitochondria and involved in zinc homeostasis, zinc mobilization as well as mitochondrial morphology and health (By similarity), In nucleus, functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes, Plays a role in transcriptional activation of Wnt-responsive genes (PubMed:15988012, PubMed:17344318)

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is Ras-related protein Rab-41 protein, from Human, contains 222 amino acids, is soluble, locates in Cytoplasm.

Required for normal Golgi ribbon organization and ER-to-Golgi trafficking

Belongs to the small GTPase superfamily, Rab family


This is Cytochrome c oxidase assembly factor 6 homolog protein, from Human, contains 125 amino acids, is soluble, locates in Mitochondrion.

Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2, Thereby, may regulate early steps of complex IV assembly, Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis, May also be required for efficient formation of respiratory supercomplexes comprised of complexes III and IV

Belongs to the cytochrome c oxidase subunit 6B family


This is Torsin-1A-interacting protein 1 protein, from Human, contains 583 amino acids, is membrane-bound, locates in Nucleus.

Required for nuclear membrane integrity, Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane, Binds to A- and B-type lamins, Possible role in membrane attachment and assembly of the nuclear lamina


This is Centrosomal protein of 78 kDa protein, from Human, contains 689 amino acids, is soluble, locates in Cytoplasm.

May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (PubMed:27246242), May play a role in cilium biogenesis (PubMed:27588451)


This is Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial protein, from Mouse-ear cress, contains 539 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Belongs to the 2-oxoacid dehydrogenase family


This is Thiamine biosynthetic bifunctional enzyme TH1, chloroplastic protein, from Mouse-ear cress, contains 522 amino acids, locates in Plastid.

Essential for thiamine biosynthesis, Bifunctional enzyme that catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP and condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)

Belongs to the thiamine-phosphate synthase family


This is Fibrillin-5, chloroplastic protein, from Mouse-ear cress, contains 273 amino acids, is soluble, locates in Plastid.

Essential for plastoquinone-9 (PQ-9) biosynthesis (PubMed:26432861, PubMed:29741733), Interacts with the diphosphate synthases SPS1 and SPS2, and binds to the hydrophobic solanesyl moiety, which is generated by SPS1 and SPS2, in FBN5-SPS homodimeric complexes to stimulate the enzyme activity of SPS1 and SPS2 (PubMed:26432861)


This is Leucine-rich repeat-containing protein 52 protein, from Mouse, contains 314 amino acids, is membrane-bound, locates in Cell membrane.

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha), Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity), KCNU1 channel auxiliary protein, May modulate KCNU1 gating properties, shifting KCNU1 gating to more negative potentials at a given pH


This is Speedy protein A protein, from Human, contains 313 amino acids, locates in Nucleus.

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555), Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995), Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962)


This is Serine/threonine-protein kinase DCLK2 protein, from Rat, contains 767 amino acids, is soluble, locates in Cytoplasm.

Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family, May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily


This is TPR repeat-containing protein ZIP4 protein, from Rice, contains 953 amino acids, locates in Nucleus.

Required for crossover formation, complete synapsis of homologous chromosomes and bivalent formation during meiosis, Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover) and works cooperatively with MER3 to promote crossovers


This is UDP-glucuronic acid decarboxylase 1 protein, from Rat, contains 420 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:11877387), Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:11877387)

Belongs to the NAD(P)-dependent epimerase/dehydratase family, UDP-glucuronic acid decarboxylase subfamily


This is Torsin-1A-interacting protein 1 protein, from Rat, contains 583 amino acids, is membrane-bound, locates in Nucleus.


This is C-type lectin domain family 12 member A protein, from Human, contains 265 amino acids, is membrane-bound, locates in Cell membrane.

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases


This is Deoxynucleotidyltransferase terminal-interacting protein 2 protein, from Human, contains 756 amino acids, locates in Nucleus.

Regulates the transcriptional activity of DNTT and ESR1, May function as a chromatin remodeling protein (PubMed:12786946, PubMed:15047147), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)


This is Alkaline ceramidase 2 protein, from Human, contains 275 amino acids, is membrane-bound, locates in Golgi apparatus.

Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856), Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939), Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856), Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856), Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055), It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity), Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990), As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990), Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876)

Belongs to the alkaline ceramidase family


This is Ermin protein, from Rat, contains 282 amino acids, is soluble, locates in Cytoplasm.

Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult, May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)


This is Dehydrogenase/reductase SDR family member 7B protein, from Rat, contains 325 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Immunoglobulin superfamily containing leucine-rich repeat protein 2 protein, from Mouse, contains 745 amino acids, has 1 Ig-like Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like

Required for axon extension during neural development


This is Lymphocyte antigen 6 complex locus protein G6f protein, from Human, contains 297 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

May play a role in the downstream signal transduction pathways involving GRB2 and GRB7


This is Mucin-21 protein, from Human, contains 566 amino acids, is membrane-bound, locates in Cell membrane.


This is Heterochromatin protein 1-binding protein 3 protein, from Human, contains 553 amino acids, locates in Nucleus.

Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416), Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860)


This is Coilin protein, from Mouse, contains 570 amino acids, locates in Nucleus.

Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs


This is Refilin-B protein, from Mouse, contains 216 amino acids, is soluble, locates in Cytoplasm.

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins, Plays an essential role in the formation of cartilaginous skeletal elements


This is Tectonic-like complex member MKS1 protein, from Mouse, contains 561 amino acids, is soluble, locates in Cytoplasm.

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes, Involved in centrosome migration to the apical cell surface during early ciliogenesis, Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication, Required for cell branching morphology


This is Low density lipoprotein receptor adapter protein 1 protein, from Human, contains 308 amino acids, is soluble, locates in Cytoplasm.

Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts), May be required for LDL binding and internalization but not for receptor clustering in coated pits, May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, May also be involved in the internalization of other LDLR family members, Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface, Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity)


This is Zinc finger protein 496 protein, from Mouse, contains 585 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 4 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

DNA-binding transcription factor that can both act as an activator and a repressor

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Polynucleotide 5'-hydroxyl-kinase NOL9 protein, from Human, contains 702 amino acids, locates in Nucleus.

Polynucleotide 5'-kinase involved in rRNA processing, The kinase activity is required for the processing of the 32S precursor into 5,8S and 28S rRNAs, more specifically for the generation of the major 5,8S(S) form, In vitro, has both DNA and RNA 5'-kinase activities, Probably binds RNA

Belongs to the Clp1 family, NOL9/GRC3 subfamily


This is Coiled-coil and C2 domain-containing protein 1B protein, from Human, contains 858 amino acids, locates in Nucleus.

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells


This is Ligand-dependent nuclear receptor-interacting factor 1 protein, from Human, contains 769 amino acids, is soluble, locates in Nucleus.

Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155), Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211), Also required for silencing of the DUX4 locus in somatic cells (PubMed:32467133)


This is Putative transferase CAF17, mitochondrial protein, from Human, contains 356 amino acids, locates in Mitochondrion.

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway

Belongs to the GcvT family, CAF17 subfamily


This is BEN domain-containing protein 3 protein, from Human, contains 828 amino acids, locates in Nucleus.

Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription, The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909), Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity), Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671)


This is DDB1- and CUL4-associated factor 12 protein, from Human, contains 453 amino acids, is soluble, locates in Cytoplasm.

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:16949367, PubMed:16964240, PubMed:29779948), The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948), The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:31267705), Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (PubMed:31267705), Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation, Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512)


This is PHD finger protein 19 protein, from Human, contains 580 amino acids, has 2 PHD-type Zinc finger, locates in Nucleus.

PHD-type

PHD-type

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:23104054, PubMed:31959557), Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351), Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal, Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054), Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832)


This is E3 ubiquitin-protein ligase RNF187 protein, from Human, contains 235 amino acids, has 1 RING-type Zinc finger, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8


This is DDB1- and CUL4-associated factor 8 protein, from Human, contains 597 amino acids, locates in Cytoplasm.

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex


This is Collagen alpha-1(XIII) chain protein, from Human, contains 717 amino acids, is membrane-bound, locates in Cell membrane.

Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development, May participate in the linkage between muscle fiber and basement membrane, May play a role in endochondral ossification of bone and branching morphogenesis of lung, Binds heparin, At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625)


This is Four and a half LIM domains protein 5 protein, from Human, contains 284 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

May be involved in the regulation of spermatogenesis, Stimulates CREM transcriptional activity in a phosphorylation-independent manner


This is Protein lin-9 homolog protein, from Human, contains 542 amino acids, is soluble, locates in Nucleus.

Acts as a tumor suppressor, Inhibits DNA synthesis, Its ability to inhibit oncogenic transformation is mediated through its association with RB1, Plays a role in the expression of genes required for the G1/S transition


This is ELAV-like protein 1-B protein, from African clawed frog, contains 326 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability, Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity), Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs, Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs, May play a role during gastrulation, Required for the vegetal localization of vg1 mRNA


This is Biogenesis of lysosome-related organelles complex 1 subunit 3 protein, from Mouse, contains 195 amino acids, is soluble, locates in Cytoplasm.

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes, In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals, The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension, Plays a role in intracellular vesicle trafficking


This is RNA-binding E3 ubiquitin-protein ligase MEX3C protein, from Human, contains 659 amino acids, has 1 RING-type Zinc finger, locates in Cytoplasm.

RING-type

E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes, Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay, RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation


This is Cytosolic carboxypeptidase 2 protein, from Human, contains 902 amino acids, is soluble, locates in Cytoplasm.

Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins, Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein, Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate, Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK


This is Tricyclene synthase TPS4, chloroplastic protein, from Barrel medic, contains 580 amino acids, is soluble, locates in Plastid.

Promotes the emission of terpenes volatile organic compounds (VOC) in response to damage mediated by arthropod herbivores (e,g, Spodoptera exigua), probably to attract natural enemies of the herbivores

Belongs to the terpene synthase family, Tpsb subfamily


This is Striatin-interacting protein 1 protein, from Human, contains 837 amino acids, is soluble, locates in Cytoplasm.

Plays a role in the regulation of cell morphology and cytoskeletal organization, Required in the cortical actin filament dynamics and cell shape


This is E3 ubiquitin-protein ligase BRE1A protein, from Human, contains 975 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively), It thereby plays a central role inb histone code and gene regulation, The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory, Required for transcriptional activation of Hox genes, Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator, Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation


This is Protein-cysteine N-palmitoyltransferase HHAT protein, from Human, contains 493 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (PubMed:18534984, PubMed:31875564, PubMed:24784881), It also catalyzes N-terminal palmitoylation of DHH (PubMed:24784881), Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs (PubMed:31875564), It is an essential factor for proper embryonic development and testicular organogenesis (PubMed:24784881)

Belongs to the membrane-bound acyltransferase family, HHAT subfamily


This is Scm-like with four MBT domains protein 2 protein, from Human, contains 894 amino acids, locates in Nucleus.

Transcriptional repressor of HOXB13 gene


This is Threonylcarbamoyladenosine tRNA methylthiotransferase protein, from Human, contains 579 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine

Belongs to the methylthiotransferase family, CDKAL1 subfamily


This is Deubiquitinase MYSM1 protein, from Human, contains 828 amino acids, locates in Nucleus.

Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:24062447, PubMed:26220525, PubMed:28115216), Participates in the normal programming of B-cell responses to antigen after the maturation process (By similarity), Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:33086059), Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (By similarity), Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (By similarity), Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059), In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:24062447), Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (PubMed:17707232)

Belongs to the peptidase M67A family, MYSM1 subfamily


This is N-terminal Xaa-Pro-Lys N-methyltransferase 2 protein, from Human, contains 283 amino acids, locates in Nucleus.

Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved, Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif (PubMed:24090352, PubMed:30417120), Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) (PubMed:30417120), May activate NTMT1 by priming its substrates for trimethylation (PubMed:24090352)

Belongs to the methyltransferase superfamily, NTM1 family


This is Protein GPR107 protein, from Human, contains 600 amino acids, is membrane-bound, locates in Golgi apparatus.

(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT, May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum


This is Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 protein, from Human, contains 232 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle, This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle, This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation, Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators

Belongs to the very long-chain fatty acids dehydratase HACD family


This is Renalase protein, from Human, contains 342 amino acids, is soluble, locates in Extracellular.

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+), The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure, Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk, High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis


This is N-alpha-acetyltransferase 35, NatC auxiliary subunit protein, from Human, contains 725 amino acids, is soluble, locates in Cytoplasm.

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues, Involved in regulation of apoptosis and proliferation of smooth muscle cells


This is Protein-lysine methyltransferase METTL21C protein, from Human, contains 264 amino acids, locates in Nucleus.

Belongs to the methyltransferase superfamily, METTL21 family


This is Neutral ceramidase protein, from Zebrafish, contains 743 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:15271994), Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation, Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine, Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (By similarity), Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity)

Belongs to the neutral ceramidase family


This is Crossover junction endonuclease MUS81 protein, from Mouse-ear cress, contains 659 amino acids, locates in Nucleus.

Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick, Typical substrates include 3'-flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency, May be required in mitosis for the processing of stalled or collapsed replication fork intermediates, Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells, Mediates a subset of meiotic recombination events that are insensitive to crossover interference, Together with SEND1, essential for the resolution of toxic replication structures to ensure genome stability, and to maintain telomere integrity and replication (PubMed:26704385)


This is DNA-(apurinic or apyrimidinic site) endonuclease protein, from Mouse-ear cress, contains 364 amino acids, locates in Nucleus.

Apurinic/apyrimidinic (AP) endonuclease involved in active DNA demethylation and gene imprinting (PubMed:25569774), According to a report, also displays an in vitro 3'-phosphatase activity (PubMed:25569774), According to another report, has no in vitro 3'-phosphatase activity (PubMed:25228464), Catalyzes the conversion of the 3'-blocking groups 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) generated by ROS1 to 3'-OH (PubMed:25228464, PubMed:25569774), Has a strong non-specific affinity to DNA (PubMed:25228464), Redundant with APE2 and at least one functional allele is required for seed viability (PubMed:19172180)

Belongs to the DNA repair enzymes AP/exoA family


This is Metalloendoproteinase 3-MMP protein, from Mouse-ear cress, contains 384 amino acids, is membrane-bound, locates in Cell membrane.

Matrix metalloproteinases (MMPs) or matrixins may play a role in the degradation and remodeling of the extracellular matrix (ECM) during development or in response to stresses (By similarity), Active on McaPLGLDpaAR-NH(2) (QF24) and beta-casein and, to some extent, on myelin basic protein (MBP) (PubMed:24156403)

Belongs to the peptidase M10A family, Matrix metalloproteinases (MMPs) subfamily


This is F-actin-capping protein subunit beta protein, from Rat, contains 272 amino acids, is soluble, locates in Cytoplasm.

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends, Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments, Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity), Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure, The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)

Belongs to the F-actin-capping protein beta subunit family


This is Rho GDP-dissociation inhibitor 1 protein, from Rat, contains 204 amino acids, is soluble, locates in Cytoplasm.

Controls Rho proteins homeostasis, Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them, Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation, Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms, Through the modulation of Rho proteins, may play a role in cell motility regulation, In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1


This is DNA replication licensing factor mcm4-A protein, from African clawed frog, contains 858 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells, Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built, The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit, The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity


This is MICOS complex subunit MIC13 protein, from Human, contains 118 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane, Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology, Required for the incorporation of MICOS10/MIC10 into the MICOS complex

Belongs to the MICOS complex subunit Mic13 family


This is Homeobox protein orthopedia protein, from Human, contains 325 amino acids, locates in Nucleus.

Probably involved in the differentiation of hypothalamic neuroendocrine cells

Belongs to the paired homeobox family, Bicoid subfamily


This is Xylosyl- and glucuronyltransferase LARGE2 protein, from Mouse, contains 690 amino acids, is membrane-bound, locates in Golgi apparatus.

Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner (PubMed:15958417, PubMed:23125099, PubMed:23135544, PubMed:25138275), Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:23125099, PubMed:23135544, PubMed:25138275), Supports the maturation of DAG1 more effectively than LARGE1 (By similarity), In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (PubMed:27496765)

Belongs to the glycosyltransferase 8 family


This is TATA box-binding protein-associated factor RNA polymerase I subunit B protein, from Mouse-ear cress, contains 666 amino acids, has 1 RRN7-type Zinc finger, locates in Nucleus.

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription, Binds rDNA promoters and plays a role in Pol I recruitment (By similarity), Required for the development of the one-cell zygote and endosperm in embryos (PubMed:15634699), Required for micropylar pollen tube guidance, but has no effect on ovule development and gametophytic cell fate specification (PubMed:18055609), May regulate the transcription of secreted cysteine-rich peptide (CRP) genes in the embryo sac (PubMed:26462908)


This is U3-agatoxin-Ao1f protein, from Funnel-web spider, contains 74 amino acids, is soluble, locates in Extracellular.

Insecticidal neurotoxin that modulates the insect Nav channel (DmNaV1/tipE (para/tipE)) in a unique manner, with both the activation and inactivation processes being affected, The voltage dependence of activation is shifted toward more hyperpolarized potentials (analogous to site 4 toxins) and a non-inactivating persistent sodium current is induced (site 3-like action), Interestingly, both effects take place in a voltage-dependent manner, producing a bell-shaped curve between -80 and 0 mV, In vivo, induces an irreversible spastic paralysis when injected into insects

Belongs to the neurotoxin 07 (Beta/delta-agtx) family, 03 (aga-4) subfamily, Aga sub-subfamily


This is RNA polymerase II C-terminal domain phosphatase-like 1 protein, from Mouse-ear cress, contains 967 amino acids, locates in Nucleus.

Processively dephosphorylates 'Ser-5' but not 'Ser-2' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1), This promotes the activity of RNA polymerase II, Together with CPL2, required for male gametes fertility, Multifunctional regulator that modulates plant growth, stress, and phytohormones responses, Negative regulator of stress gene transcription involved in abscisic acid (ABA) mediated and jasmonic acid (JA) mediated signaling pathways, NaCl, osmotic stress, wounding, and cold resistance, Regulates negatively the expression of jasmonic acid (JA) biosynthetic genes in response to wounding (PubMed:11874572, PubMed:12149434, PubMed:12149453, PubMed:15388846, PubMed:18506580, PubMed:18764923), Forms a complex with RCF3 that modulates co-transcriptional processes such as mRNA capping and polyadenylation, and functions to repress stress-inducible gene expression (PubMed:23874224), Dephosphorylates RCF3 (PubMed:26227967), Involved in the dephosphorylation of EIF4A3, This dephosphorylation retains EIF4A3 in the nucleus and limits its accumulation in the cytoplasm, Is essential for the degradation of the nonsense-mediated mRNA decay (NMD) transcripts (PubMed:26887918)


This is Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG protein, from Rice, contains 242 amino acids, is soluble, locates in Cytoplasm.

Cytokinin-activating enzyme working in the direct activation pathway, Controls the shoot meristem activity, Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms, Reacts specifically with cytokinin nucleoside 5'-monophosphates, but not with di- or triphosphate


This is Cytochrome b-c1 complex subunit Rieske, mitochondrial protein, from Chicken, contains 272 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer, One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS) (By similarity), The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function (By similarity)

Belongs to the Rieske iron-sulfur protein family


This is GDP-D-glucose phosphorylase 1 protein, from Caenorhabditis elegans, contains 482 amino acids, is soluble, locates in Cytoplasm.

Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells


This is Bile acid receptor protein, from Mouse, contains 488 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Activates transcription of IBAP and SDC1

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Inhibitor of nuclear factor kappa-B kinase subunit alpha protein, from Mouse, contains 745 amino acids, locates in Cytoplasm.

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses, Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis, Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11), Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation, As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes, In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis, Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilizing MAP3K14/NIK, Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities, Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP (PubMed:12789342), Additionally, phosphorylates the CREBBP-interacting protein NCOA3, Also phosphorylates FOXO3 and may regulate this pro-apoptotic transcription factor, Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (PubMed:30988283), Phosphorylates AMBRA1 following mitophagy induction, promoting AMBRA1 interaction with ATG8 family proteins and its mitophagic activity (By similarity)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily


This is KH domain-containing, RNA-binding, signal transduction-associated protein 1 protein, from Mouse, contains 443 amino acids, is membrane-bound, locates in Nucleus.

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors, Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins, Role in G2-M progression in the cell cycle, Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP, Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export, Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation, May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species, RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion, Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides, Binds poly(A), In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (By similarity), Can regulate CD44 alternative splicing in a Ras pathway-dependent manner, Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners, In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4, The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (PubMed:12478298, PubMed:22196734, PubMed:24469635)


This is Growth factor receptor-bound protein 10 protein, from Mouse, contains 621 amino acids, is soluble, locates in Cytoplasm.

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways, Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors, The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation, Delays and reduces AKT1 phosphorylation in response to insulin stimulation, Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation, Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways, A similar role in the mediation of ubiquitination has also been suggested with INSR, Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6, Positive regulator of the KDR/VEGFR-2 signaling pathway, May inhibit NEDD4-mediated degradation of KDR/VEGFR-2


This is Krueppel-like factor 4 protein, from Mouse, contains 483 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor; can act both as activator and as repressor, Binds the 5'-CACCC-3' core sequence (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Binds to the promoter region of its own gene and can activate its own transcription (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Regulates the expression of key transcription factors during embryonic development (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation (PubMed:10431239, PubMed:10556311, PubMed:15358627, PubMed:16954384, PubMed:17060454, PubMed:19816951, PubMed:20071344, PubMed:29593216), Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface, Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development, Contributes to the down-regulation of p53/TP53 transcription (By similarity)

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Interleukin-17 receptor A protein, from Mouse, contains 864 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway


This is ALS2 C-terminal-like protein protein, from Mouse, contains 952 amino acids, is soluble, locates in Cytoplasm.

Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase, Regulates the ALS2-mediated endosome dynamics (By similarity)


This is ALS2 C-terminal-like protein protein, from Human, contains 953 amino acids, is soluble, locates in Cytoplasm.

Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase, Regulates the ALS2-mediated endosome dynamics


This is T-cell differentiation antigen CD6 protein, from Mouse, contains 665 amino acids, is membrane-bound, locates in Cell membrane.

Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166, Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089), Functions as costimulatory molecule; promotes T-cell activation and proliferation, Contributes to the formation and maturation of the immunological synapse, Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria, Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria, LPS binding leads to the activation of signaling cascades and down-stream MAP kinases, Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS