This is Probably inactive leucine-rich repeat receptor-like protein kinase At5g48380 protein, from Mouse-ear cress, contains 620 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Photosynthetic NDH subunit of lumenal location 5, chloroplastic protein, from Mouse-ear cress, contains 259 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable), PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Responsible, with FKBP13, for all PPIase activity observed in thylakoid lumen, Modulates the conformation of BZR1, which regulates flowering (PubMed:16765949, PubMed:23897924)

Belongs to the cyclophilin-type PPIase family


This is Sphinganine C4-monooxygenase 2 protein, from Mouse-ear cress, contains 259 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis, Can use C18- and C20-sphinganine as substrates to produce C18- and C20-phytosphinganines (D-ribo-2-amino-1,3,4-trihydroxyoctadecane and -eicosane)


This is Hydroxyproline O-galactosyltransferase GALT3 protein, from Mouse-ear cress, contains 619 amino acids, is membrane-bound, locates in Golgi apparatus.

Possesses hydroxyproline O-galactosyltransferase activity, Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs), Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues, Utilizes UDP-galactose solely as sugar donor, The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition, AGP glycans play essential roles in both vegetative and reproductive plant growth

Belongs to the glycosyltransferase 31 family


This is Protein TRIGALACTOSYLDIACYLGLYCEROL 3, chloroplastic protein, from Mouse-ear cress, contains 345 amino acids, is soluble, locates in Plastid.

ATPase transporter involved in lipid transfer from the endoplasmic reticulum (ER) to plastids, and necessary for thylakoids formation, Not involved in transition metal transport pathways (PubMed:20132520)

Belongs to the ABC transporter superfamily, ABCI family


This is Transcriptional adapter ADA2b protein, from Mouse-ear cress, contains 487 amino acids, has 1 ZZ-type Zinc finger, locates in Nucleus.

ZZ-type

Required for the function of some acidic activation domains, which activate transcription from a distant site, The exact mechanism of action is not yet known (By similarity), ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region, Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (PubMed:12615937, PubMed:12747832), Involved in the positive regulation of salt-induced gene expression by maintaining locus-specific acetylation of histones H4 and H3 (PubMed:21193996)


This is Acyl-coenzyme A synthetase ACSM1, mitochondrial protein, from Bovine, contains 577 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077), Capable of activating medium-chain fatty acids (e,g, butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e,g, benzoate (PubMed:10561077, PubMed:11382754), Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754), Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Conotoxin elongated-tx3a-a protein, from Cloth-of-gold cone, contains 70 amino acids, is soluble, locates in Extracellular.

Intracranial injection into mice causes scratching and hyperactivity (PubMed:15924437), In vitro, inhibits proliferation of the mice ovarian cancer cells ID8 (PubMed:36235146)


This is Potassium channel toxin gamma-KTx 2.1 protein, from Lesser Asian scorpion, contains 57 amino acids, is soluble, locates in Extracellular.

Blocks human and/or rat Kv11,1/KCNH2/ERG1, Kv11,2/KCNH6/ERG2 and Kv11,3/KCNH7/ERG3 by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry, Inhibition data are the following: hERG1 (reversible, Kd=7,7 nM (PubMed:16497878), IC(50)=3,3 nM (PubMed:11136720), IC(50)=11,9 nM (PubMed:21205913)), rERG1 (reversible, Kd=19 nM) (PubMed:16497878), hERG2 (reversible, Kd=77 nM) (PubMed:16497878), rERG2 (irreversible, Kd=4,2 nM) (PubMed:16497878), hERG3 (reversible, Kd=11,5 nM) (PubMed:16497878) and rERG3 (reversible, Kd=747 nM) (PubMed:16497878) potassium channels, Has also a minimal effect on rat ELK1/KCNH4 potassium channels (9% inhibition at 100 nM (PubMed:15137031)), Both this toxin and CnErgTx1 (AC Q86QT3) share mechanism of action and have overlapping binding sites on ERG1 (PubMed:12719233), The potency of these two toxins is not affected by elevating potassium ion concentration from 2 to 98 mM (PubMed:12719233), In addition, at high toxin concentrations, block of ERG1 macroscopic currents by these two toxins is incomplete (88%) (PubMed:12719233), The blockade by this toxin is preferentially closed channel state-dependent, with a component of open, but not inactive state-dependent blockade (PubMed:12860380), This toxin produces a concentration-dependent prolongation of QTc in the isolated rabbit heart (16,3% at 100 nM) (PubMed:21205913)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Gamma-KTx 2 subfamily


This is Mitochondrial prohibitin complex protein 1 protein, from Caenorhabditis elegans, contains 275 amino acids, is membrane-bound, locates in Mitochondrion.

PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad, A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells


This is Protein Fe65 homolog protein, from Caenorhabditis elegans, contains 665 amino acids, is soluble, locates in Cytoplasm.

Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2 (PubMed:11896189, PubMed:15355315)


This is Probable U2 small nuclear ribonucleoprotein A' protein, from Caenorhabditis elegans, contains 253 amino acids, locates in Nucleus.

This protein is associated with sn-RNP U2, It helps the A' protein to bind stem loop IV of U2 snRNA, Required maternally for early embryonic development and zygotically for germline and somatic development, Has a role in the switch from mitosis to meiosis, Might function in alternative splicing

Belongs to the U2 small nuclear ribonucleoprotein A family


This is Dehydrogenase/reductase SDR family member 9 protein, from Human, contains 319 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409), Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084), Can utilize both NADH and NADPH

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is 17-beta-hydroxysteroid dehydrogenase 14 protein, from Human, contains 270 amino acids, is soluble, locates in Cytoplasm.

Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity, Converts oestradiol to oestrone, The physiological substrate is not known, Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro)


This is Calcium uptake protein 1, mitochondrial protein, from Human, contains 476 amino acids, is membrane-bound, locates in Mitochondrion.

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988), MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium, MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221), Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221), Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221), Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319), Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733)

Belongs to the MICU1 family, MICU1 subfamily


This is Spindlin-2B protein, from Human, contains 258 amino acids, locates in Nucleus.

Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692), Exhibits H3K4me3-binding activity (PubMed:29061846)


This is Polyadenylate-binding protein-interacting protein 2 protein, from Human, contains 127 amino acids, is soluble, locates in Cytoplasm.

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs, Its inhibitory activity on translation is mediated via its action on PABPC1, Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1, Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization


This is SOSS complex subunit B1 protein, from Human, contains 211 amino acids, locates in Nucleus.

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620), In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines, The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability, Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways

Belongs to the SOSS-B family, SOSS-B1 subfamily


This is Potassium voltage-gated channel subfamily S member 3 protein, from Human, contains 491 amino acids, is membrane-bound, locates in Cell membrane.

Potassium channel subunit that does not form functional channels by itself, Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328), Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity)

Belongs to the potassium channel family, S (TC 1,A,1,2) subfamily, Kv9,3/KCNS3 sub-subfamily


This is ATP-dependent RNA helicase DDX50 protein, from Human, contains 737 amino acids, locates in Nucleus.

Belongs to the DEAD box helicase family, DDX21/DDX50 subfamily


This is U6 snRNA phosphodiesterase 1 protein, from Human, contains 265 amino acids, locates in Nucleus.

3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753), Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:23022480, PubMed:22899009, PubMed:26213367, PubMed:31832688, PubMed:23190533, PubMed:28887445, PubMed:30215753), In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367)

Belongs to the 2H phosphoesterase superfamily, USB1 family


This is Glutamate-rich WD repeat-containing protein 1 protein, from Human, contains 446 amino acids, locates in Nucleus.

Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725)


This is ADP-ribose glycohydrolase MACROD1 protein, from Human, contains 325 amino acids, locates in Nucleus.

Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712), Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712), Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746), Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568), Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849), May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104), Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104), Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710), Enhances ESR1-mediated transcription activity (PubMed:17914104)


This is Ribosome quality control complex subunit TCF25 protein, from Human, contains 676 amino acids, locates in Nucleus.

Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831), In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831), Also acts as a transcriptional repressor: represses transcription of SRF in vitro and so may play a role in heart development (PubMed:16574069), May play a role in cell death control (By similarity)


This is Protein FAM110A protein, from Human, contains 295 amino acids, is soluble, locates in Cytoplasm.


This is Vitamin K epoxide reductase complex subunit 1 protein, from Human, contains 163 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vitamin K metabolism, Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K, Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development


This is NAD-capped RNA hydrolase NUDT12 protein, from Human, contains 462 amino acids, locates in Peroxisome.

mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550), The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919), Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919), Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796), May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796), Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity)

Belongs to the Nudix hydrolase family, NudC subfamily


This is Mitochondrial genome maintenance exonuclease 1 protein, from Human, contains 344 amino acids, locates in Mitochondrion.

Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance, Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates, Necessary for maintenance of proper 7S DNA levels, Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair, Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells


This is Thioredoxin domain-containing protein 17 protein, from Human, contains 123 amino acids, is soluble, locates in Cytoplasm.

Disulfide reductase, May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions, Modulates TNF-alpha signaling and NF-kappa-B activation, Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide


This is Serine/threonine-protein phosphatase CPPED1 protein, from Human, contains 314 amino acids, is soluble, locates in Cytoplasm.

Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis, May play an inhibitory role in glucose uptake by adipocytes

Belongs to the metallophosphoesterase superfamily, CPPED1 family


This is Proton-coupled zinc antiporter SLC30A2 protein, from Human, contains 372 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is Serine/arginine-rich splicing factor 8 protein, from Human, contains 282 amino acids, locates in Nucleus.

Involved in pre-mRNA alternative splicing

Belongs to the splicing factor SR family


This is Vesicle-trafficking protein SEC22c protein, from Human, contains 303 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in vesicle transport between the ER and the Golgi complex


This is Partner of Y14 and mago protein, from Human, contains 204 amino acids, locates in Cytoplasm.

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation, Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs, Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated, Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions, May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC


This is MICOS complex subunit MIC25 protein, from Human, contains 235 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Belongs to the MICOS complex subunit Mic19 family, Metazoan Mic25 subfamily


This is La-related protein 6 protein, from Human, contains 491 amino acids, locates in Cytoplasm.

Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2, Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR, This regulation requires VIM and MYH10 filaments, and the helicase DHX9


This is Suppressor of IKBKE 1 protein, from Human, contains 207 amino acids, is soluble, locates in Cytoplasm.

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3, Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter, May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI, Does not inhibit NF-kappa-B activation pathways


This is Peroxiredoxin-like 2A protein, from Human, contains 229 amino acids, is soluble, locates in Cytoplasm.

Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071), Acts as an antioxidant (PubMed:19951071, PubMed:26438880), Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071), May affect bone resorption and help to maintain bone mass (PubMed:19951071), Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880)

Belongs to the peroxiredoxin-like PRXL2 family, PRXL2A subfamily


This is RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 protein, from Human, contains 238 amino acids, locates in Nucleus.

Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase, Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner, Required for the progression of the G1 to S phase transition, Plays a role in the stimulation of CHEK1 phosphorylation


This is Small membrane A-kinase anchor protein protein, from Human, contains 95 amino acids, is membrane-bound, locates in Cell membrane.

Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane

Belongs to the small membrane AKAP family


This is Translational activator of cytochrome c oxidase 1 protein, from Human, contains 297 amino acids, locates in Mitochondrion.

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1


This is TERF1-interacting nuclear factor 2 protein, from Human, contains 451 amino acids, locates in Nucleus.

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, Plays a role in shelterin complex assembly, Isoform 1 may have additional role in tethering telomeres to the nuclear matrix


This is Ubiquitin-associated domain-containing protein 1 protein, from Human, contains 405 amino acids, is soluble, locates in Cytoplasm.

Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1 (PubMed:15531880, PubMed:15746103, PubMed:16227581, PubMed:25860612), The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (PubMed:15531880, PubMed:15746103), The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor (PubMed:25860612), Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome (PubMed:16227581)


This is Polycomb group RING finger protein 1 protein, from Human, contains 259 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A, Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway, Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element), Promotes cell cycle progression and enhances cell proliferation as well, May have a positive role in tumor cell growth by down-regulating CDKN1A, Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332), Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479)


This is Protein YIPF4 protein, from Human, contains 244 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in the maintenance of the Golgi structure


This is tRNA-splicing endonuclease subunit Sen34 protein, from Human, contains 310 amino acids, locates in Nucleus.

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA, It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron, The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini, There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body, It probably carries the active site for 3'-splice site cleavage, The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events

Belongs to the tRNA-intron endonuclease family


This is EF-hand calcium-binding domain-containing protein 4B protein, from Human, contains 731 amino acids, is soluble, locates in Cytoplasm.

Rab GTPase that mediates the trafficking of Weibel-Palade bodies (WPBs) to microtubule organizing center (MTOC) in endothelial cells in response to acute inflammatory stimuli (PubMed:31092558), During histamine (but not thrombin) stimulation of endothelial cells, the dynein-bound form induces retrograde transport of a subset of WPBs along microtubules to the MTOC in a Ca(2+)-independent manner and its GTPase activity is essential for this function (PubMed:31092558), Ca(2+)-regulated dynein adapter protein that activates dynein-mediated transport and dynein-dynactin motility on microtubules and regulates endosomal trafficking of CD47 (PubMed:30814157), Acts as an intracellular signaling module bridging two important T-cell receptor (TCR) signaling pathways, Ca(2+)-NFAT and JNK, to affect T-cell activation (PubMed:27016526), In resting T-cells, is predominantly localized near TGN network in a GTP-bound form, upon TCR stimulation, localizes at the immunological synapse via interaction with VAV1 to activate downstream Ca(2+)-NFAT and JNK signaling pathways (PubMed:27016526), Plays a role in T-helper 1 (Th1) cell differentiation and T-helper 17 (Th17) cell effector function (PubMed:29987160), Plays a role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation (PubMed:27016526)


This is Mitochondrial ribosome-associated GTPase 1 protein, from Human, contains 334 amino acids, is membrane-bound, locates in Mitochondrion.

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity, Displays mitochondrial GTPase activity

Belongs to the TRAFAC class YlqF/YawG GTPase family, MTG1 subfamily


This is HAUS augmin-like complex subunit 8 protein, from Human, contains 410 amino acids, is soluble, locates in Cytoplasm.

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex


This is Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial protein, from Human, contains 221 amino acids, is soluble, locates in Mitochondrion.

May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757), Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents, Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923), ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923), Does not display DNA demethylase activity (PubMed:23666923), Involved in fatty acid metabolism (By similarity)


This is Inositol polyphosphate 5-phosphatase K protein, from Human, contains 448 amino acids, locates in Endoplasmic reticulum.

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732), Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883), Negatively regulates assembly of the actin cytoskeleton, Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity)

Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family


This is WW domain-containing adapter protein with coiled-coil protein, from Human, contains 647 amino acids, locates in Nucleus.

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1) (PubMed:21329877), Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription (PubMed:21329877), Regulates the cell-cycle checkpoint activation in response to DNA damage (PubMed:21329877), Positive regulator of amino acid starvation-induced autophagy (PubMed:22354037), Also acts as a negative regulator of basal autophagy (PubMed:26812014), Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex, This leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014), May negatively regulate the ubiquitin proteasome pathway (PubMed:21329877)


This is Metastasis-associated protein MTA3 protein, from Human, contains 594 amino acids, has 1 GATA-type; atypical Zinc finger, locates in Nucleus.

GATA-type; atypical

Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12705869, PubMed:28977666), Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869), Contributes to transcriptional repression by BCL6 (PubMed:15454082)


This is Mini-chromosome maintenance complex-binding protein protein, from Human, contains 642 amino acids, locates in Nucleus.

Associated component of the MCM complex that acts as a regulator of DNA replication, Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA, Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex, Required for sister chromatid cohesion


This is PAXIP1-associated glutamate-rich protein 1 protein, from Human, contains 254 amino acids, locates in Nucleus.

Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation, However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex, Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460), However, its function in DNA damage has been questioned (By similarity), During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (By similarity), Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (PubMed:19039327), Acts as transcriptional cofactor for nuclear hormone receptors, Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (PubMed:23161582)


This is RNA guanine-N7 methyltransferase activating subunit protein, from Human, contains 118 amino acids, locates in Nucleus.

Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871), Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT (PubMed:27422871), Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306), Binds RNA (PubMed:22099306)


This is Transmembrane protein 208 protein, from Human, contains 173 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May function as a negative regulator of endoplasmic reticulum-stress induced autophagy


This is Thiamine-triphosphatase protein, from Human, contains 230 amino acids, is soluble, locates in Cytoplasm.

Hydrolase highly specific for thiamine triphosphate (ThTP)


This is Transmembrane protein 70, mitochondrial protein, from Human, contains 260 amino acids, is membrane-bound, locates in Mitochondrion.

Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (PubMed:31652072, PubMed:33753518, PubMed:33359711, PubMed:32275929), Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:33359711, PubMed:18953340, PubMed:20937241, PubMed:31652072), In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (PubMed:32275929)


This is Iron-sulfur cluster assembly 1 homolog, mitochondrial protein, from Human, contains 129 amino acids, locates in Mitochondrion.

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway, Probably involved in the binding of an intermediate of Fe/S cluster assembly


This is Protein PAXX protein, from Human, contains 204 amino acids, locates in Nucleus.

Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:25574025, PubMed:25670504, PubMed:25941166, PubMed:27705800), May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:25574025, PubMed:25670504, PubMed:25941166), Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (PubMed:27703001), Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:30250067, PubMed:25670504), Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27705800), Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism (PubMed:29144403)

Belongs to the XRCC4-XLF family, PAXX subfamily


This is Heterogeneous nuclear ribonucleoprotein U-like protein 1 protein, from Human, contains 856 amino acids, locates in Nucleus.

Acts as a basic transcriptional regulator, Represses basic transcription driven by several virus and cellular promoters, When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation, Also plays a role in mRNA processing and transport, Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro


This is Protein misato homolog 1 protein, from Human, contains 570 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28554942, PubMed:28544275), Required for mitochondrial fusion and mitochondrial network formation (PubMed:28554942, PubMed:28544275)


This is Glucose-6-phosphatase 3 protein, from Human, contains 346 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum, May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis, Probably required for normal neutrophil function

Belongs to the glucose-6-phosphatase family


This is Coiled-coil domain-containing protein 28B protein, from Human, contains 200 amino acids, is soluble, locates in Cytoplasm.

Involved in ciliogenesis, Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex, Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation, Does not seem to modulate assembly and function of mTORC1 complex


This is Derlin-1 protein, from Human, contains 251 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

(Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains, Also participates in the degradation process of misfolded cytomegalovirus US2 protein


This is Probable ATP-dependent RNA helicase DDX23 protein, from Human, contains 820 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142), Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779)

Belongs to the DEAD box helicase family, DDX23/PRP28 subfamily


This is Dehydrogenase/reductase SDR family member 6 protein, from Human, contains 245 amino acids, is soluble, locates in Cytoplasm.

NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (PubMed:35150746) (By similarity), Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746), Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress, The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity), May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Methyltransferase-like protein 22 protein, from Human, contains 404 amino acids, locates in Nucleus.

Protein N-lysine methyltransferase, Trimethylates KIN at Lys-135 (in vitro)

Belongs to the methyltransferase superfamily, METTL22 family


This is N-terminal Xaa-Pro-Lys N-methyltransferase 1 protein, from Human, contains 223 amino acids, locates in Nucleus.

Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved, Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif, Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352), Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1), Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET, Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1

Belongs to the methyltransferase superfamily, NTM1 family


This is U11/U12 small nuclear ribonucleoprotein 25 kDa protein protein, from Human, contains 132 amino acids, locates in Nucleus.


This is ER degradation-enhancing alpha-mannosidase-like protein 2 protein, from Human, contains 578 amino acids, is soluble, locates in Endoplasmic reticulum.

Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655), May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655), Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity)

Belongs to the glycosyl hydrolase 47 family


This is E3 ubiquitin-protein ligase TRIM62 protein, from Human, contains 475 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways (PubMed:26488816), E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2 (PubMed:23402750)


This is Nucleolar complex protein 4 homolog protein, from Human, contains 516 amino acids, is membrane-bound, locates in Nucleus.


This is Guanine nucleotide-binding protein-like 3 protein, from Human, contains 549 amino acids, locates in Nucleus.

May be required to maintain the proliferative capacity of stem cells, Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)

Belongs to the TRAFAC class YlqF/YawG GTPase family


This is tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial protein, from Human, contains 477 amino acids, locates in Mitochondrion.

Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428), Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568), In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537)

Belongs to the class I-like SAM-binding methyltransferase superfamily, TRM61 family


This is Transmembrane protein 106C protein, from Human, contains 250 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Specifically androgen-regulated gene protein protein, from Human, contains 601 amino acids, is soluble, locates in Cytoplasm.


This is Elongation of very long chain fatty acids protein 1 protein, from Human, contains 279 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246), This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle, Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA, May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators, Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905), Indirectly inhibits RPE65 via production of VLCFAs

Belongs to the ELO family, ELOVL1 subfamily


This is Cyclin-dependent kinase 2-interacting protein protein, from Human, contains 212 amino acids, locates in Nucleus.

Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979), Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:19889979), Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024), Promotes maturation of pre-60S ribosome together with AFG2A, AFG2B and AIRIM (PubMed:35354024)


This is HIRA-interacting protein 3 protein, from Human, contains 556 amino acids, locates in Nucleus.

May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones


This is Coiled-coil domain-containing protein 106 protein, from Human, contains 280 amino acids, locates in Nucleus.

Promotes the degradation of p53/TP53 protein and inhibits its transactivity


This is Replication initiator 1 protein, from Human, contains 567 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 14 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; atypical

Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication, Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone, Facilitates DNA bending


This is Sideroflexin-3 protein, from Human, contains 321 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778), Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778)


This is Poly(A) polymerase gamma protein, from Human, contains 736 amino acids, locates in Nucleus.

Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA

Belongs to the poly(A) polymerase family


This is PHD finger protein 7 protein, from Human, contains 381 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type Zinc finger, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

C2HC pre-PHD-type

PHD-type

RING-type; degenerate


This is Adenosine 5'-monophosphoramidase HINT2 protein, from Human, contains 163 amino acids, locates in Mitochondrion.

Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367), Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638), Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367), May be involved in steroid biosynthesis (PubMed:18653718), May play a role in apoptosis (PubMed:16762638)


This is BTB/POZ domain-containing protein 2 protein, from Human, contains 525 amino acids, is soluble, locates in Cytoplasm.


This is Succinate receptor 1 protein, from Human, contains 334 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the G-protein coupled receptor 1 family


This is Leucine-rich repeat-containing G-protein coupled receptor 4 protein, from Human, contains 951 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs, Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes, In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal, Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye, May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo, Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells, Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts, Acts as a regulator of bone formation and remodeling, Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state, Involved in the development of the anterior segment of the eye, Required during erythropoiesis, Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production, Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity), Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity)


This is Spermatogenesis-associated protein 16 protein, from Human, contains 569 amino acids, locates in Golgi apparatus.

Essential for spermiogenesis and male fertility (By similarity), Involved in the formation of sperm acrosome during spermatogenesis


This is Bcl-2-binding component 3, isoforms 1/2 protein, from Human, contains 193 amino acids, locates in Mitochondrion.

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338), Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338), Regulates ER stress-induced neuronal apoptosis (By similarity)


This is Complement C1q tumor necrosis factor-related protein 4 protein, from Human, contains 329 amino acids, is soluble, locates in Extracellular.

May be involved in the regulation of the inflammatory network, Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950), Seems to have some role in regulating food intake and energy balance when administered in the brain, This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (By similarity)


This is Cell division cycle-associated protein 4 protein, from Human, contains 241 amino acids, locates in Nucleus.

May participate in the regulation of cell proliferation through the E2F/RB pathway, May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity)


This is Asporin protein, from Human, contains 380 amino acids, is soluble, locates in Extracellular.

Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system, Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity), Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis, Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal, Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity

Belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class I subfamily


This is Solute carrier family 12 member 9 protein, from Human, contains 914 amino acids, is membrane-bound, locates in Cell membrane.

May be an inhibitor of SLC12A1, Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function

Belongs to the SLC12A transporter family


This is Ubiquitin carboxyl-terminal hydrolase 26 protein, from Human, contains 913 amino acids, locates in Nucleus.

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity), Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway


This is Emopamil-binding protein-like protein, from Human, contains 206 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Does not possess sterol isomerase activity and does not bind sigma ligands


This is Protein DGCR6L protein, from Human, contains 220 amino acids, locates in Nucleus.

May play a role in neural crest cell migration into the third and fourth pharyngeal pouches


This is Inosine triphosphate pyrophosphatase protein, from Human, contains 194 amino acids, is soluble, locates in Cytoplasm.

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives, The enzyme does not distinguish between the deoxy- and ribose forms, Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions


This is Peroxisomal trans-2-enoyl-CoA reductase protein, from Human, contains 303 amino acids, locates in Peroxisome.

Participates in chain elongation of fatty acids, Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA, Has no 2,4-dienoyl-CoA reductase activity


This is UDP-glucuronosyltransferase 2B28 protein, from Human, contains 529 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Lack UDP-glucuronosyltransferase (UGT) activity

Belongs to the UDP-glycosyltransferase family


This is Angiopoietin-related protein 4 protein, from Human, contains 406 amino acids, is soluble, locates in Extracellular.

Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism (PubMed:19270337, PubMed:21398697, PubMed:27929370, PubMed:29899144), Has higher activity in LPL inactivation than the uncleaved protein (PubMed:19270337, PubMed:21398697)


This is Polycomb group RING finger protein 6 protein, from Human, contains 350 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Transcriptional repressor (PubMed:12167161), May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162), Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332)


This is NF-kappa-B inhibitor zeta protein, from Human, contains 718 amino acids, locates in Nucleus.

Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:16513645, PubMed:16622025), Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:16513645), Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:16513645), Seems also to activate NF-kappa-B-mediated transcription (PubMed:16622025), In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (PubMed:16622025), Promotes transcription of LCN2 and DEFB4 (PubMed:16622025), Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity), Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity), Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity)


This is E3 ubiquitin-protein ligase TRIM34 protein, from Human, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

Functions as antiviral protein and contributes to the defense against retroviral infections (PubMed:17156811, PubMed:32282853), Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses (PubMed:32282853), During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination (PubMed:35065966), In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis (PubMed:35065966), Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis (PubMed:31956709), Promotes also the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells (PubMed:31487507)


This is Sulfiredoxin-1 protein, from Human, contains 137 amino acids, is soluble, locates in Cytoplasm.

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625), Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625), May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625)


This is Alanine--glyoxylate aminotransferase 2, mitochondrial protein, from Human, contains 514 amino acids, locates in Mitochondrion.

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV), ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family


This is Carotenoid-cleaving dioxygenase, mitochondrial protein, from Human, contains 579 amino acids, locates in Mitochondrion.

Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids, Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond, Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules

Belongs to the carotenoid oxygenase family


This is Solute carrier family 2, facilitated glucose transporter member 11 protein, from Human, contains 496 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily


This is Regenerating islet-derived protein 4 protein, from Human, contains 158 amino acids, is soluble, locates in Extracellular.

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment, May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium


This is GTP-binding protein 4 protein, from Human, contains 634 amino acids, locates in Nucleus.

Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547), Acts as TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539)

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, NOG subfamily


This is Ubiquitin-like protein 5 protein, from Human, contains 73 amino acids, is soluble, locates in Cytoplasm.


This is Protein phosphatase 1 regulatory subunit 12C protein, from Human, contains 782 amino acids, is soluble, locates in Cytoplasm.


This is Group IIF secretory phospholipase A2 protein, from Human, contains 168 amino acids, is soluble, locates in Extracellular.

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids, Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443), May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity)


This is Apoptosis facilitator Bcl-2-like protein 14 protein, from Human, contains 327 amino acids, is soluble, locates in Cytoplasm.


This is Transmembrane 6 superfamily member 2 protein, from Human, contains 377 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523), May function as sterol isomerase (PubMed:25566323)


This is Tripartite motif-containing protein 6 protein, from Human, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

(Microbial infection) Ubiquitinates ebolavirus protein VP35 leading to enhanced viral transcriptase activity


This is E3 ubiquitin-protein ligase TRIM4 protein, from Human, contains 500 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

E3 ubiquitin-protein ligase, Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction


This is INO80 complex subunit B protein, from Human, contains 356 amino acids, has 1 HIT-type Zinc finger, locates in Nucleus.

HIT-type

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is RING finger protein unkempt homolog protein, from Human, contains 810 amino acids, has 5 C3H1-type Zinc finger, has 1 RING-type; degenerate Zinc finger, is soluble, locates in Cytoplasm.

RING-type; degenerate

Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development, Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system, Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif, Associated with polysomes (PubMed:25737280)


This is Alpha-ketoglutarate-dependent dioxygenase FTO protein, from Human, contains 505 amino acids, locates in Nucleus.

RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335), Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335), M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295), Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295), Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295), Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401), Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295), Has no activity towards 1-methylguanine (PubMed:20376003), Has no detectable activity towards double-stranded DNA (PubMed:20376003), Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003), Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003), Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003), Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746), Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity), Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359)


This is Zinc finger protein 436 protein, from Human, contains 470 amino acids, has 12 C2H2-type Zinc finger, locates in Nucleus.

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein tweety homolog 3 protein, from Human, contains 523 amino acids, is membrane-bound, locates in Cell membrane.

Probable large-conductance Ca(2+)-activated chloride channel, May play a role in Ca(2+) signal transduction


This is Myotubularin-related protein 12 protein, from Human, contains 747 amino acids, is soluble, locates in Cytoplasm.

Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870), Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870), By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is Crossover junction endonuclease eme1 protein, from Fission yeast, contains 735 amino acids, locates in Nucleus.

Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick, Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions, May be required in mitosis for the processing of stalled or collapsed replication fork intermediates, May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)


This is Catalase-1 protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 736 amino acids, is soluble, locates in Extracellular.

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide


This is Geranylgeranyl pyrophosphate synthase paxG protein, from Penicillium paxilli, contains 371 amino acids, locates in Peroxisome.

Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of paxilline, a mycotoxin that acts as an inhibitor of mammalian maxi-K channels (PubMed:11169115, PubMed:23949005, PubMed:16494875, PubMed:19529962), PaxG, the geranylgeranyl diphosphate (GGPP) synthase is proposed to catalyze the first step in paxilline biosynthesis (PubMed:23949005, PubMed:16494875, PubMed:19529962), Condensation of indole-3-glycerol phosphate with GGPP by paxC then forms 3-geranylgeranylindole (3-GGI), followed by epoxidation and cyclization of this intermediate (by paxM and paxB) to form paspaline (PubMed:23949005, PubMed:16494875), Paspaline is subsequently converted to 13-desoxypaxilline by paxP, the latter being then converted to paxilline by paxQ (PubMed:23949005), Finally paxilline can be mono- and di-prenylated by paxD (PubMed:23949005)


This is Mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 protein, from Mouse-ear cress, contains 560 amino acids, is membrane-bound, locates in Golgi apparatus.

Class I alpha-mannosidase essential for early N-glycan processing, Progressively trims alpha-1,2-linked mannose residues, Produces Man(5)GlcNAc(2) from Man(8)GlcNAc(2), but only Man(6)GlcNAc(2) from Man(9)GlcNAc(2), Has difficulty acting on the terminal mannose of the b-branch, Involved in root development and cell wall biosynthesis


This is Extra-large guanine nucleotide-binding protein 3 protein, from Mouse-ear cress, contains 848 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity), Binds GTP with specificity, Plays a role in the root morphogenesis by regulation of the cell proliferation, Acts with GB1 in the positive regulation of root waving and root skewing

Belongs to the G-alpha family, XLG subfamily


This is WRKY transcription factor 6 protein, from Mouse-ear cress, contains 553 amino acids, locates in Nucleus.

Transcription factor involved in the control of processes related to senescence and pathogen defense (PubMed:12000796), Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:12000796), Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes (PubMed:12000796), Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression (PubMed:25733771)


This is Replication factor C subunit 1 protein, from Mouse-ear cress, contains 956 amino acids, locates in Nucleus.

Plays a role as mediator of transcriptional gene silencing (TGS), DNA replication, DNA repair, hypersensitive response (HR) and telomere length regulation, Is required in meiosis for DNA double-strand break (DSB) repair during meiotic homologous recombination, May participate in the RAD51-mediated recombination intermediate repair process, Is important for lagging strand synthesis, Promotes meiotic recombination via a specific pathway for crossovers (COs) that involves the formation of double Holliday Junction (dHJ) intermediates

Belongs to the activator 1 large subunit family


This is Mitogen-activated protein kinase 18 protein, from Mouse-ear cress, contains 615 amino acids, is soluble, locates in Cytoplasm.

Mitogen-activated protein kinase (MAPK) that is specifically regulated by PHS1 and MAPKKK20 and mediates signaling that regulates cortical microtubule functions, maybe through regulation of microtubule dynamic instability

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily


This is Peptide methionine sulfoxide reductase B2, chloroplastic protein, from Mouse-ear cress, contains 202 amino acids, locates in Plastid.

Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins, Specifically reduces the MetSO R-enantiomer, Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation, May play an essential function in association with MSRB1 in maintaining vegetative growth during environmental constraints, through the preservation of photosynthetic antennae, MSRB1 and MSRB2 account for most of the leaf peptide MSR capacity

Belongs to the MsrB Met sulfoxide reductase family


This is Protein SUPPRESSOR OF FRI 4 protein, from Mouse-ear cress, contains 367 amino acids, has 1 BED-type Zinc finger, locates in Nucleus.

BED-type

Sequence-specific DNA binding factor that recognizes the 5'-CCAAATTTTAAGTTT-3' sequence, Recruits the FRI-C complex to the FLC promoter, Required for FRI-mediated FLC activation, but has no effect on the expression of MAF1, MAF2, MAF3, MAF5, UFC and CO, Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development


This is ATP-dependent 6-phosphofructokinase 7 protein, from Mouse-ear cress, contains 485 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Belongs to the phosphofructokinase type A (PFKA) family, PPi-dependent PFK group II subfamily, Atypical ATP-dependent clade 'X' sub-subfamily


This is ABSCISIC ACID-INSENSITIVE 5-like protein 3 protein, from Mouse-ear cress, contains 262 amino acids, locates in Nucleus.

Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 gene promoter, Could participate in abscisic acid-regulated gene expression during seed development

Belongs to the bZIP family, ABI5 subfamily


This is Small RNA 2'-O-methyltransferase protein, from Mouse-ear cress, contains 942 amino acids, locates in Nucleus.

Methyltransferase that adds a methyl group to the ribose of the last nucleotide of small RNAs (sRNAs), This protects the 3'-end of sRNAs from uridylation activity and subsequent degradation, Can methylate 3'-end of microRNAs (miRNAs), small interfering RNAs (siRNas) and trans-acting small interfering RNAs (ta-siRNAs), Involved in plant development through its role in small RNAs processing, Required for the specification of reproductive organ identities and the probable repression of A class genes, May control floral determinacy possibly by regulating the expression of the C class floral homeotic gene AGAMOUS (AG)

Belongs to the methyltransferase superfamily, HEN1 family


This is Phospholipase D delta protein, from Mouse-ear cress, contains 868 amino acids, is membrane-bound, locates in Cell membrane.

Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA), May be involved in PA accumulation in the dehydration stress response and in the transduction of hormonal and environmental signals to the microtubules cytoskeleton (PubMed:11549769, PubMed:11489173, PubMed:12881496), Prefers phosphatidylethanolamine to phosphatidylcholine as substrate (PubMed:12397060), Involved in H(2)O(2) and abscisic acid (ABA)-induced stomatal closure (PubMed:22589465, PubMed:22392280), Involved in nitric oxide (NO) signaling during stomatal closure (PubMed:22932846), Plays a positive role in ABA-promoted senescence (PubMed:23762411), Involved in basal defense and nonhost resistance (PubMed:23979971)

Belongs to the phospholipase D family, C2-PLD subfamily


This is Photosystem I chlorophyll a/b-binding protein 5, chloroplastic protein, from Mouse-ear cress, contains 256 amino acids, is membrane-bound, locates in Plastid.

The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated (PubMed:15563470, PubMed:21806943), Seems involved in the function of the photosystem I in low light conditions, when other LHCA proteins are less abundant (PubMed:15356385), Required, together with LHCA6, for the formation of a full-size NAD(P)H dehydrogenase-photosystem I supercomplex (NDH-PSI) that triggers cyclic and chlororespiratory electron transport in chloroplast thylakoids, especially under stress conditions (e,g, increased light intensity) (Probable) (PubMed:19903870, PubMed:21278308)

Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family


This is Chaperonin 60 subunit beta 4, chloroplastic protein, from Mouse-ear cress, contains 611 amino acids, is soluble, locates in Plastid.

Involved specifically in the folding of NDHH, a subunit of the chloroplast NADH dehydrogenase-like complex (NDH)

Belongs to the chaperonin (HSP60) family


This is Gamma carbonic anhydrase 2, mitochondrial protein, from Mouse-ear cress, contains 278 amino acids, is membrane-bound, locates in Mitochondrion.

Enzyme involved in the catabolism of H(2)CO(3) but that does not mediates the reversible hydration of carbon dioxide (PubMed:19808034), Mediates complex I assembly in mitochondria and respiration, Binds HCO(3)-, Required for male fertility during anther development and dehiscence to regulate the secondary thickenings of the endothecial cell wall, probably by modulating H(2)O(2)-dependent lignin polymerization

Belongs to the gamma-class carbonic anhydrase family


This is Auxin efflux carrier component 1 protein, from Mouse-ear cress, contains 622 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a component of the auxin efflux carrier, Seems to be involved in the basipetal auxin transport, Mediates the formation of auxin gradient which is required to ensure correct organogenesis, Coordinated polar localization of PIN1 is directly regulated by the vesicle trafficking process and apical-basal PIN1 polarity also depends on the phosphorylation of conserved serine residues by PID kinase, The ARF-GEF protein GNOM is required for the correct recycling of PIN1 between the plasma membrane and endosomal compartments

Belongs to the auxin efflux carrier (TC 2,A,69,1) family


This is Probable 9-cis-epoxycarotenoid dioxygenase NCED5, chloroplastic protein, from Mouse-ear cress, contains 589 amino acids, is membrane-bound, locates in Plastid.

Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity, Catalyzes the first step of abscisic-acid biosynthesis from carotenoids (By similarity)

Belongs to the carotenoid oxygenase family


This is Probable inositol transporter 2 protein, from Mouse-ear cress, contains 580 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane inositol-proton symporter, Specific for several inositol epimers, such as myoinositol and scylloinositol, D-chiroinositol, mucoinositol, alloinositol and pinitol are also transported with a lower activity, Not active with galactinol and phytate

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family


This is Protein EMSY-LIKE 1 protein, from Mouse-ear cress, contains 327 amino acids, locates in Nucleus.

Probably involved in the regulation of chromatin states (Probable), Contributes to RPP7-mediated and basal immunity, especially against Hyaloperonospora arabidopsidis isolate Hiks1, Regulates negatively EDM2-dependent floral transition (PubMed:21830950)


This is Xanthoxin dehydrogenase protein, from Mouse-ear cress, contains 285 amino acids, is soluble, locates in Cytoplasm.

Involved in the biosynthesis of abscisic acid (PubMed:12172025, PubMed:12417697, PubMed:9159947, PubMed:10972885), Catalyzes the conversion of xanthoxin to abscisic aldehyde (PubMed:12417697, PubMed:9159947, PubMed:12172025)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Trihelix transcription factor GTL1 protein, from Mouse-ear cress, contains 587 amino acids, locates in Nucleus.

Transcription repressor that binds specific DNA sequence such as GT3 box 5'-GGTAAA-3' in the SDD1 promoter (PubMed:21169508), Negative regulator of water use efficiency (WUE) via the promotion of stomatal density and distribution by the transcription repression of SDD1 (PubMed:21169508), Regulates the expression of several cell cycle genes and endoreduplication, especially in trichomes where it prevents ploidy-dependent plant cell growth (PubMed:19717615), Regulates negatively root hair growth by directly binding RSL4 promoter and repressing RSL4 expression (PubMed:29439132)


This is Phospholipase D alpha 4 protein, from Mouse-ear cress, contains 762 amino acids, is membrane-bound, locates in Cell membrane.

Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA), Promotes growth and plays a role in nitrogen signaling


This is E3 ubiquitin-protein ligase BRE1-like 2 protein, from Mouse-ear cress, contains 900 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1, H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me, It thereby plays a central role in histone code and gene regulation, Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6


This is Protein PLASTID MOVEMENT IMPAIRED 1 protein, from Mouse-ear cress, contains 843 amino acids, is soluble, locates in Cytoplasm.

Necessary for chloroplast and nuclear photorelocation movements via the regulation of chloroplast-actin (cp-actin) filaments in mesophyll cells, and together with PMIR1, in pavement cells (PubMed:26324877), Required component for both the low- and high-light-dependent chloroplast movement responses via an abscisic acid (ABA) pathway (PubMed:16113226, PubMed:25154696), Involved in the ABA response pathway during seed germination, Modulates ABA accumulation during periods of water deficit at the seedling stage (PubMed:25154696)


This is Protein TRAUCO protein, from Mouse-ear cress, contains 509 amino acids, locates in Nucleus.

Trithorax-group gene homolog required for early embryogenesis (PubMed:20118203, PubMed:21423667), Required for the expression of FLC and FLC homologs and represses flowering (PubMed:21423667), Required for proper leaf growth and development (PubMed:21423667), Part of COMPASS-like complexes responsible for H3K4 trimethylation, but not for di- or mono-methylation of histone H3 'Lys-4' (PubMed:21423667), Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:21423667), Involved in the transition from transcription initiation to transcription elongation (PubMed:23284292)


This is ABC transporter G family member 12 protein, from Mouse-ear cress, contains 687 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Required for the polarization of reflected light on both adaxial and abaxial leaves surfaces upon viral infection by Turnip vein clearing virus (TVCV), probably by regulating cuticular wax compounds deposition, thus influencing visual attractiveness of infected plants for insect vectors

Belongs to the ABC transporter superfamily, ABCG family, Eye pigment precursor importer (TC 3,A,1,204) subfamily


This is Persulfide dioxygenase ETHE1 homolog, mitochondrial protein, from Mouse-ear cress, contains 294 amino acids, locates in Mitochondrion.

Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix, Hydrogen sulfide (H(2)S) gives rise to cysteine persulfide residues, ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH), Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase, Required for normal endosperm development in seed, and thereby also required for normal embryo development

Belongs to the metallo-beta-lactamase superfamily, Glyoxalase II family


This is Peptide methionine sulfoxide reductase B1, chloroplastic protein, from Mouse-ear cress, contains 202 amino acids, locates in Plastid.

Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins, Specifically reduces the MetSO R-enantiomer, Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation, May play an essential function in association with MSRB2 in maintaining vegetative growth during environmental constraints, through the preservation of photosynthetic antennae, MSRB1 and MSRB2 account for most of the leaf peptide MSR capacity


This is NAC domain-containing protein 30 protein, from Mouse-ear cress, contains 324 amino acids, locates in Nucleus.

Required for the soilborne fungal pathogen Verticillium longisporum-induced transdifferentiation of chloroplast-containing bundle sheath cells to functional xylem elements leading to stunted growth, vein clearing, and leaf chloroses, as well as xylem hyperplasia within the vasculature of leaves, hypocotyls, and roots due to reinitiation of cambial activity and transdifferentiation of xylem parenchyma cells, This developmental reprogramming mediates also an increased drought stress tolerance

Belongs to the plant vascular related NAC-domain protein family


This is DELLA protein RGL1 protein, from Mouse-ear cress, contains 511 amino acids, locates in Nucleus.

Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway, No effect of the BOI proteins on its stability, Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes, Has overlapping but distinct roles in GA signaling compared to RGA and GAI, Regulates the floral development, May also participate in seed germination and in ovule and anther development, Its activity is probably regulated by other phytohormones such as auxin and ethylene

Belongs to the GRAS family, DELLA subfamily


This is Glycine-rich RNA-binding protein 5, mitochondrial protein, from Mouse-ear cress, contains 289 amino acids, locates in Mitochondrion.

Possibly has a role in RNA transcription or processing during stress (By similarity), Binds RNAs and DNAs sequence with a preference to single-stranded nucleic acids, Displays strong affinity to poly(U) sequence (PubMed:11972043), Involved in C-to-U editing of mitochondrial RNA, Functions as major mitochondrial editing factor, Controls 44 percent of the mitochondrial editing sites (PubMed:26578708)


This is Nuclear/nucleolar GTPase 2 protein, from Mouse-ear cress, contains 576 amino acids, locates in Nucleus.

GTPase involved in pre-60S ribosomal subunit maturation

Belongs to the TRAFAC class YlqF/YawG GTPase family, RsgA subfamily


This is Serine protease SPPA, chloroplastic protein, from Mouse-ear cress, contains 677 amino acids, is membrane-bound, locates in Plastid.

Serine protease that may be involved in the light-dependent degradation of antenna and photosystem II in chloroplasts, May function during high light acclimation in plastids


This is Cytosolic sulfotransferase 18 protein, from Mouse-ear cress, contains 350 amino acids, is soluble, locates in Cytoplasm.

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of desulfo-glucosinolates (dsGSs), the final step in the biosynthesis of the glucosinolate core structure, Preferred substrate are the long-chain desulfo-glucosinolates, 7-methylthioheptyl and 8-methylthiooctyl, derived from methionine, Substrate preference is desulfo-benzyl glucosinolate > desulfo-4-methylthiobutyl glucosinolate > desulfo-6-methylthiohexyl glucosinolate > desulfo-3-methylthiopropyl glucosinolate > desulfo-indol-3-yl methyl glucosinolate > desulfo-singrin > desulfo-3-butenyl glucosinolate

Belongs to the sulfotransferase 1 family


This is Cytosolic sulfotransferase 16 protein, from Mouse-ear cress, contains 338 amino acids, is soluble, locates in Cytoplasm.

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of desulfo-glucosinolates (dsGSs), the final step in the biosynthesis of the glucosinolate core structure, Substrate preference is desulfo-2-phenylethyl glucosinolate > desulfo-indol-3-yl methyl glucosinolate > desulfo-benzyl glucosinolate > desulfo-6-methylthiohexyl glucosinolate > desulfo-4-methylthiobutyl glucosinolate > desulfo-3-methylthiopropyl glucosinolate > desulfo-singrin > desulfo-3-butenyl glucosinolate


This is Protein TIFY 11B protein, from Mouse-ear cress, contains 269 amino acids, locates in Nucleus.


This is Calvin cycle protein CP12-3, chloroplastic protein, from Mouse-ear cress, contains 134 amino acids, locates in Plastid.

Acts as a linker essential in the assembly of a core complex of PRK/GAPDH, Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues


This is AT-hook motif nuclear-localized protein 29 protein, from Mouse-ear cress, contains 302 amino acids, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity), Acts redundantly with AHL18, AHL22 and AHL27 in the regulation of flowering and regulation of the hypocotyl elongation (PubMed:19517252), Acts redundantly with AHL27/ESC to modulate hypocotyl growth inhibition in response to light (PubMed:18088311)


This is Heme oxygenase 3, chloroplastic protein, from Mouse-ear cress, contains 285 amino acids, locates in Plastid.

Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO), Produces specifically the biliverdin IX-alpha isomer, Plays a minor role in phytochrome assembly and photomorphogenesis


This is 3-oxoacyl-[acyl-carrier-protein] synthase II, chloroplastic protein, from Mouse-ear cress, contains 541 amino acids, is soluble, locates in Plastid.

Essential protein that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP, Specific for elongation from C-16 and C-16 to unsaturated C-18 fatty acids, Confers resistance to low temperatures by maintaining chloroplast membranes integrity, Involved in the regulation of fatty acids ratios during seed metabolism, Required for embryo development, especially at the transition from the globular to the heart stage

Belongs to the thiolase-like superfamily, Beta-ketoacyl-ACP synthases family


This is J domain-containing protein required for chloroplast accumulation response 1 protein, from Mouse-ear cress, contains 651 amino acids, is soluble, locates in Cytoplasm.

Required for chloroplast photorelocation movement; chloroplast accumulation upon low blue light and for chloroplast movement to the bottom of cells in darkness, by modulating chloroplast actin (Cp-actin) filaments distribution, appearance and disappearance, May mediate a slight resistance to aluminum in root hair cells


This is Probable pectin methyltransferase QUA2 protein, from Mouse-ear cress, contains 684 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in the synthesis of homogalacturonan, Required for normal cell adhesion and plant development

Belongs to the methyltransferase superfamily


This is Protein SAR DEFICIENT 1 protein, from Mouse-ear cress, contains 451 amino acids, locates in Nucleus.

Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes (PubMed:20921422, PubMed:21615571, PubMed:23153277), Recruited to the promoter of ICS1 and other defense-related genes (e,g, PR1 and SID2) in response to both biotic (e,g, Pseudomonas syringae pv, maculicola ES4326) and abiotic stresses (e,g, UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis, Required for basal and systemic acquired resistance to P, syringae pv, maculicola and Hyaloperonospora arabidopsidis (PubMed:20921422, PubMed:21615571)

Belongs to the plant ACBP60 protein family


This is Cyclin-dependent kinase D-1 protein, from Mouse-ear cress, contains 398 amino acids, locates in Nucleus.

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily


This is Glycerate dehydrogenase HPR, peroxisomal protein, from Mouse-ear cress, contains 386 amino acids, locates in Peroxisome.

Catalyzes the NADH-dependent reduction of hydroxypyruvate into glycerate in the photorespiratory core cycle, Mediates fatty acid beta-oxidation in germinating seeds when malate dehydrogenase is absent

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family


This is Microtubule-associated protein 70-1 protein, from Mouse-ear cress, contains 622 amino acids, is soluble, locates in Cytoplasm.

Plant-specific protein that interact with microtubules, In association with MAP70,5, is essential for the normal banding pattern of secondary cell wall and for the proper development of xylem tracheary elements and wood formation


This is Thioredoxin H9 protein, from Mouse-ear cress, contains 140 amino acids, is membrane-bound, locates in Cell membrane.

Probable thiol-disulfide oxidoreductase that may play a role in intercellular communication due to its ability to move from cell to cell

Belongs to the thioredoxin family, Plant H-type subfamily


This is Nudix hydrolase 1 protein, from Mouse-ear cress, contains 147 amino acids, is soluble, locates in Cytoplasm.

Mediates the hydrolysis of some nucleoside diphosphate derivatives, Its substrate specificity is unclear, In vitro, it can use NTP, dNTP, 8-oxo-GTP, 8-oxo-dGTP, dGTP, dATP, dTTP or dihydroneopterin triphosphate (DHNTP) as substrate, Has some NADH pyrophosphatase activity in vitro; however, such activity may not be relevant in vivo due to the high concentration of manganese used during the experiments, Plays an important role in protection against oxidative DNA and RNA damage by removing oxidatively damaged form of guanine


This is Mini zinc finger protein 1 protein, from Mouse-ear cress, contains 102 amino acids, has 1 ZF-HD dimerization-type; degenerate Zinc finger, is soluble, locates in Cytoplasm.

ZF-HD dimerization-type; degenerate

Inhibits zinc finger homeodomain (ZHD) transcription factors, such as ZHD5, by interacting with them to prevent both their nuclear localization and their DNA-binding properties, Involved in integrating signals from multiple hormones by preventing the expression of genes involved in gibberellic acid (GA), auxin and brassinosteroid signaling and by promoting the expression of abscisic acid (ABA)-responsive genes, Regulates several development aspects, including photomorphogenesis, apical dominance, longevity, flower morphology and fertility, as well as root and stem elongation, Promotes the formation of ectopic shoot meristems on leaf margins


This is Geranylgeranyl diphosphate reductase, chloroplastic protein, from Mouse-ear cress, contains 467 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the reduction of geranylgeranyl diphosphate to phytyl diphosphate, providing phytol for both tocopherol and chlorophyll synthesis

Belongs to the geranylgeranyl reductase family, ChlP subfamily


This is Probable xyloglucan 6-xylosyltransferase 5 protein, from Mouse-ear cress, contains 457 amino acids, is membrane-bound, locates in Golgi apparatus.

Probable xyloglucan xylosyltransferase involved in the biosynthesis of xyloglucan in roots, May act in association with XXT1 and XXT2 (PubMed:18557833), Associates with other xyloglucan-synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi (PubMed:25392066)

Belongs to the glycosyltransferase 34 family