This is Tyrosine-protein kinase BTK protein, from Mouse, contains 659 amino acids, has 1 Btk-type Zinc finger, locates in Cytoplasm.

Btk-type

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling (PubMed:7538439, PubMed:8629002, PubMed:10852954), Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity), After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members (By similarity), PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK (By similarity), BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways (By similarity), Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway (PubMed:17725607), The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense (By similarity), Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells (By similarity), Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation (By similarity), BTK also plays a critical role in transcription regulation (By similarity), Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes (By similarity), BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B (By similarity), Acts as an activator of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (PubMed:34554188), Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR (PubMed:11120822, PubMed:16738337), GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression (PubMed:11120822, PubMed:16738337), ARID3A and NFAT are other transcriptional target of BTK (PubMed:11120822, PubMed:16738337), BTK is required for the formation of functional ARID3A DNA-binding complexes (PubMed:11120822, PubMed:16738337), There is however no evidence that BTK itself binds directly to DNA (PubMed:11120822, PubMed:16738337), BTK has a dual role in the regulation of apoptosis (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, TEC subfamily


This is Mitochondrial intermediate peptidase protein, from Baker's yeast, contains 772 amino acids, is soluble, locates in Mitochondrion.

Cleaves proteins, imported into the mitochondrion, to their mature size, While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane, Cleaves precursor proteins of respiratory components, including subunits of the electron transport chain and tricarboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism


This is Nitrogen network kinase 1 protein, from Baker's yeast, contains 928 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase involved in the phosphorylation of the NAD(+)-dependent glutamate dehydrogenase GDH2, When overexpressed, confers hypersensitivity to rapamycin and induces rapid nuclear accumulation of GLN3 to activate the transcription of nitrogen-regulated genes

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Cell pattern formation-associated protein stuA protein, from Aspergillus nidulans, contains 622 amino acids, locates in Nucleus.

Transcription factor that regulates asexual reproduction (PubMed:1516832, PubMed:8722771, PubMed:9312029, PubMed:25550299), Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (PubMed:9312029, PubMed:25359270), Required from the very earliest events of asexual reproduction until completion of conidiophore development, but is not specifically required for differentiation of conidia (PubMed:1516832), Represses transcription of the abaA developmental regulatory gene and of the developmentally regulated awh11 gene (PubMed:9312029), Controls the expression of the catalase-peroxidase gene cpeA (PubMed:12455692), Plays an important role in cell wall biogenesis during the development by controlling the transcription level of fksA (PubMed:25359270)


This is NAD-dependent malic enzyme, mitochondrial protein, from Baker's yeast, contains 669 amino acids, is soluble, locates in Mitochondrion.


This is Monocarboxylate transporter 8 protein, from Human, contains 539 amino acids, is membrane-bound, locates in Cell membrane.

Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient, Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:23550058, PubMed:26426690, PubMed:16887882, PubMed:27805744, PubMed:20628049, PubMed:18337592, PubMed:31436139), Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) (PubMed:28526555)

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is Cell wall integrity sensor MID2 protein, from Baker's yeast, contains 376 amino acids, is membrane-bound, locates in Cell membrane.

Cell wall stress sensor, Involved in activation of a response that includes both stress-related increased chitin synthesis and the MPK1 mitogen-activated protein kinase cell integrity pathway, High-copy activator of the SKN7 transcription factor, Required during induction of MPK1 tyrosine phosphorylation under a variety of stress conditions, Required for PKC pathway activation under low pH conditions, Required for cell integrity signaling during pheromone-induced morphogenesis, Activates ROM1 or ROM2 catalyzed guanine nucleotide exchange toward RHO1 in cell wall integrity signaling

Belongs to the MID2 like cell wall stress sensor family


This is Ferric/cupric reductase transmembrane component 2 protein, from Baker's yeast, contains 711 amino acids, is membrane-bound, locates in Cell membrane.

Metalloreductase responsible for reducing extracellular iron and copper prior to import, Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores, Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane, Also participates in Cu(2+) reduction and Cu(+) uptake

Belongs to the ferric reductase (FRE) family


This is rRNA-processing protein EBP2 protein, from Baker's yeast, contains 427 amino acids, locates in Nucleus.

Required for the processing of the 27S pre-rRNA, Probably involved in the step of the processing of the 27 SA precursor into the 27 SB intermediate


This is SWI5-dependent HO expression protein 2 protein, from Baker's yeast, contains 246 amino acids, locates in Cytoplasm.

RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease, Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell, Recruits the MYO4-SHE3 complex to the ASH1 mRNA, Recruits also LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA


This is Coenzyme A biosynthesis protein 3 protein, from Baker's yeast, contains 571 amino acids, is soluble, locates in Cytoplasm.

Component of the phosphopantothenoylcysteine decarboxylase (PPCDC) involved in the coenzyme A synthesis

Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily


This is Transmembrane E3 ubiquitin-protein ligase 1 protein, from Baker's yeast, contains 758 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Golgi apparatus.

RING-type; atypical

Catalytic component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:25078903, PubMed:29355480), Mediates ubiquitination of vacuolar proteins such as CPS1, PPN1, PEP12 and other proteins containing exposed hydrophilic residues within their transmembrane domains, leading to their sorting into internal vesicles in late endosomes (PubMed:11788821), Targets also the unpalmitoylated endosomal SNARE TLG1 to the MVB pathway (PubMed:15973437)


This is PAN2-PAN3 deadenylation complex subunit PAN3 protein, from Baker's yeast, contains 679 amino acids, has 1 C3H1-type Zinc finger, is soluble, locates in Cytoplasm.

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover, PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1, PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex, Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping by DCP1-DCP2 and subsequent 5'-3' exonucleolytic degradation by XRN1, May also be involved in post-transcriptional maturation of mRNA poly(A) tails, trimming the tails from their synthesized length to the slightly shorter, apparently messenger-specific length found on newly exported mRNAs, PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1, PAN cooperates with protein kinase DUN1 in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress

Belongs to the protein kinase superfamily, PAN3 family


This is COMPASS component SWD2 protein, from Baker's yeast, contains 329 amino acids, locates in Nucleus.

Involved in mediating RNA polymerase II termination, Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB, Component of the APT complex, which may be involved in polyadenylation-independent transcript 3'-end formation


This is Large ribosomal subunit protein eL14A protein, from Baker's yeast, contains 138 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL14 family


This is Inositol phosphorylceramide synthase catalytic subunit AUR1 protein, from Baker's yeast, contains 401 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis


This is MICOS complex subunit MIC60 protein, from Baker's yeast, contains 540 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane, Plays a role in keeping cristae membranes connected to the inner boundary membrane, Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway

Belongs to the MICOS complex subunit Mic60 family


This is Arrestin-related trafficking adapter 6 protein, from Baker's yeast, contains 915 amino acids, is soluble, locates in Cytoplasm.

May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli


This is Protein BCH2 protein, from Baker's yeast, contains 765 amino acids, is membrane-bound, locates in Golgi apparatus.

Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3


This is CCR4-associated factor 4 protein, from Baker's yeast, contains 643 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in mitochondrial fission, Has a partially redundant function to MDV1 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes, Plays a key role in determining the polarized localization of those DNM1 clusters that are not immediately involved in the mitochondrial fission process

Belongs to the WD repeat MDV1/CAF4 family


This is Ribosome biogenesis protein RPF2 protein, from Baker's yeast, contains 344 amino acids, locates in Nucleus.

Required for biogenesis of the 60S ribosomal subunit


This is Ras-related protein Rab-11A protein, from Social amoeba, contains 214 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for normal contractile vacuole structure and function, Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders, These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles

Belongs to the small GTPase superfamily, Rab family


This is Large ribosomal subunit protein bL31m protein, from Baker's yeast, contains 177 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:24675956), Overexpression of bL31m suppresses mutations in the COX2 leader peptide-encoding and initiation codon regions (PubMed:11259585, PubMed:15166137)

Belongs to the bacterial ribosomal protein bL31 family, Highly divergent


This is Squalene synthase protein, from Fission yeast, contains 460 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes by the late steps of the pathway (PubMed:8474436), Erg9 produces squalene from 2 farnesyl pyrophosphate moieties (PubMed:8474436), The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane, Firstly, the squalene synthase erg9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids, Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase erg1 and the lanosterol synthase erg7, The lanosterol 14-alpha-demethylase erg11/cyp1 catalyzes C14-demethylation of lanosterol to produce 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol, In the next steps, a complex process involving various demethylation, reduction and desaturation reactions catalyzed by the C-14 reductase erg24 and the C-4 demethylation complex erg25-erg26-erg27 leads to the production of zymosterol, Erg28 likely functions in the C-4 demethylation complex reaction by tethering erg26 and Erg27 to the endoplasmic reticulum or to facilitate interaction between these proteins, Then, the sterol 24-C-methyltransferase erg6 catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol, The C-8 sterol isomerase erg2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol, The sterol-C5-desaturases erg31 and erg32 then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol, The C-22 sterol desaturase erg5 further converts 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain, Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase erg4 to produce ergosterol (PubMed:18310029) (Probable), In the genus Schizosaccharomyces, a second route exists between lanosterol and fecosterol, via the methylation of lanosterol to eburicol by erg6, followed by C14-demethylation by erg11/cyp1 and C4-demethylation by the demethylation complex erg25-erg26-erg27 (PubMed:8586261) (Probable)

Belongs to the phytoene/squalene synthase family


This is Cyclin mcs2 protein, from Fission yeast, contains 322 amino acids, locates in Nucleus.

Essential for progression through the cell cycle, Posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate

Belongs to the cyclin family, Cyclin C subfamily


This is Serine/threonine-protein phosphatase ppe1 protein, from Fission yeast, contains 305 amino acids, locates in Nucleus.

Has a role in chromosome segregation, May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin, Negatively regulates mis12

Belongs to the PPP phosphatase family, PP-6 (PP-V) subfamily


This is Splicing factor U2AF 59 kDa subunit protein, from Fission yeast, contains 517 amino acids, locates in Nucleus.

Necessary for the splicing of pre-mRNA, The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns

Belongs to the splicing factor SR family


This is Lon protease homolog, mitochondrial protein, from Human, contains 959 amino acids, is soluble, locates in Mitochondrion.

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix, May also have a chaperone function in the assembly of inner membrane protein complexes, Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome, Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner, May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235), Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m, bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575)


This is Bone morphogenetic protein receptor type-1B protein, from Mouse, contains 502 amino acids, is membrane-bound, locates in Cell membrane.

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, Receptor for BMP7/OP-1, Receptor for GDF5 (PubMed:26105076, PubMed:19229295), Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149)

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily


This is DNA-directed RNA polymerase II subunit RPB9 protein, from Human, contains 125 amino acids, has 1 C4-type Zinc finger, has 1 TFIIS-type Zinc finger, locates in Nucleus.

TFIIS-type

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity)

Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family


This is Phosphoglucomutase 2 protein, from Baker's yeast, contains 569 amino acids, is soluble, locates in Cytoplasm.

Major phosphoglucomutase isozyme that catalyzes the reversible interconversion of glucose 1-phosphate and glucose 6-phosphate (PubMed:5784209), Constitutes about 80-90% of the phosphoglucomutase activity in the cell (PubMed:14264884, PubMed:5231755), Key enzyme in hexose metabolism, The forward reaction is an essential step in the energy metabolism of galactose since the product of the galactose pathway enzymes in yeast is glucose 1-phosphate, The reverse reaction is an essential step for biosynthesis when carbon sources other than galactose are the energy source because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose (PubMed:14264884)

Belongs to the phosphohexose mutase family


This is Serine/threonine-protein kinase receptor R3 protein, from Human, contains 503 amino acids, is membrane-bound, locates in Cell membrane.

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development, On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases, Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, May bind activin as well


This is 17-beta-hydroxysteroid dehydrogenase type 3 protein, from Human, contains 310 amino acids, locates in Endoplasmic reticulum.

Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:8075637, PubMed:16216911, PubMed:27927697, PubMed:26545797), Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:27927697, PubMed:26545797), Testosterone is the key androgen driving male development and function (PubMed:8075637), Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911), Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed:16216911), Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697)

Belongs to the short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily


This is Amiloride-sensitive sodium channel subunit gamma protein, from Rat, contains 650 amino acids, is membrane-bound, locates in Cell membrane.

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride (PubMed:9118951, PubMed:8188647), Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells (PubMed:9118951, PubMed:8188647), Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus (By similarity), Controls the reabsorption of sodium in kidney, colon, lung and sweat glands, Also plays a role in taste perception (By similarity)

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family, SCNN1G subfamily


This is Bifunctional 15-cis-phytoene synthase, chromoplastic protein, from Capsicum pepper, contains 419 amino acids, is soluble, locates in Plastid.

Catalyzes the two steps reaction converting geranylgeranyl diphosphate to phytoene via prephytoene diphosphate


This is Rab proteins geranylgeranyltransferase component A 1 protein, from Rat, contains 650 amino acids, is soluble, locates in Cytoplasm.

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex, Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction, The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane, Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation


This is Peroxiredoxin AHP1 protein, from Baker's yeast, contains 176 amino acids, is soluble, locates in Cytoplasm.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events, Preferentially eliminates organic peroxides rather than hydrogen peroxide (PubMed:10391912, PubMed:9988687, PubMed:10681558), Relays alkyl hydroperoxides as a signal to the transcription factor CAD1/YAP2 by inducing the formation of intramolecular disulfide bonds in CAD1, which causes its nuclear accumulation and activation (PubMed:20145245), Involved in cellular Mn(2+) homeostasis (PubMed:10635552)

Belongs to the peroxiredoxin family, Prx5 subfamily


This is Ribose-phosphate pyrophosphokinase 4 protein, from Baker's yeast, contains 326 amino acids, is soluble, locates in Cytoplasm.

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis, Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Belongs to the ribose-phosphate pyrophosphokinase family


This is Alpha-1,2-mannosyltransferase MNN2 protein, from Baker's yeast, contains 597 amino acids, is membrane-bound, locates in Golgi apparatus.

Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides


This is Enoyl-[acyl-carrier-protein] reductase, mitochondrial protein, from Baker's yeast, contains 380 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II), Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro, Required for respiration and the maintenance of the mitochondrial compartment

Belongs to the zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily


This is Protein arginine N-methyltransferase 1 protein, from Baker's yeast, contains 348 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in a variety of RNA-binding proteins such as heterogeneous nuclear ribonucleoproteins (hnRNPs) and small nuclear ribonucleoproteins (snRNPs) (PubMed:8668183, PubMed:8647869), Methylates NAB2, NPL3, HRP1 and YRA1, shuttling hnRNPs involved in mRNA processing and export, facilitating their export out of the nucleus (PubMed:8668183, PubMed:9499403, PubMed:10652296, PubMed:11779864, PubMed:15314027), Methylation of NPL3 weakens its interaction with THO2, a component of the TREX (transcription/export) complex important for transcriptional elongation and recruitment of mRNA export factors (PubMed:15314027, PubMed:20053728), Methylates the hnRNP HRB1, but does not influence its subcellular location (PubMed:9499403), Methylates the nucleolar proteins GAR1, NOP1 and NSR1 (PubMed:12756332), Methylates the snRNP SNP1 and modulates the cotranscriptional recruitment of splicing factors (PubMed:20823272), Dimethylates free histone H4 (HHF1/HHF2) at 'Arg-4' (H4R3me2a) and plays a role in preservation and establishment of silent chromatin domains (PubMed:12097318, PubMed:17158743), Mono- and dimethylates ribosomal protein S2 (RPS2) at 'Arg-11' (PubMed:20035717), Methylates the catalytic subunit of the SWI/SNF chromatin-remodeling complex SNF2 (PubMed:22997150)

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family


This is Leu/Val/Ile amino-acid permease protein, from Baker's yeast, contains 609 amino acids, is membrane-bound, locates in Cell membrane.

Permease for leucine, valine and isoleucine, Also transports cysteine, methionine, phenyalanine, tyrosine and tryptophan

Belongs to the amino acid-polyamine-organocation (APC) superfamily, YAT (TC 2,A,3,10) family


This is DNA repair and recombination protein RDH54 protein, from Baker's yeast, contains 958 amino acids, locates in Nucleus.

Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis, Has DNA dependent ATPase activity, Promotes D-loop (displacement loop) formation with RAD51 recombinase, Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate, Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends, This role is distinct from its roles in recombination, Promotes colocalization of RAD51 and DMC1 during meiotic recombination, Involved in crossover interference

Belongs to the SNF2/RAD54 helicase family


This is ATP-dependent RNA helicase MAK5 protein, from Baker's yeast, contains 773 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5,8S rRNAs, Required for the maintenance of dsRNA killer plasmid

Belongs to the DEAD box helicase family, DDX24/MAK5 subfamily


This is ADP-ribosylation factor-like protein 1 protein, from Baker's yeast, contains 183 amino acids, locates in Golgi apparatus.

Recruits golgins such as IMH1 to the Golgi, Can bind and hydrolyze GTP, May be involved in trafficking events within the endosomal system

Belongs to the small GTPase superfamily, Arf family


This is Glucosidase 2 subunit alpha protein, from Baker's yeast, contains 954 amino acids, locates in Endoplasmic reticulum.

Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins

Belongs to the glycosyl hydrolase 31 family


This is RNA-binding motif protein, X chromosome protein, from Human, contains 391 amino acids, locates in Nucleus.

RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes, Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs, Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression, When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter, Associates with nascent mRNAs transcribed by RNA polymerase II, Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection, Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2, Represses the splicing of MAPT/Tau exon 10, Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer, Binds non-specifically to pre-mRNAs, Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment


This is Kynurenine 3-monooxygenase protein, from Baker's yeast, contains 460 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn), Required for synthesis of quinolinic acid

Belongs to the aromatic-ring hydroxylase family, KMO subfamily


This is Methionine aminopeptidase 2 protein, from Baker's yeast, contains 421 amino acids, is soluble, locates in Cytoplasm.

Cotranslationally removes the N-terminal methionine from nascent proteins, The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val), Plays only a minor role in N-terminal methionine removal, Less efficient when the second residue is Val, Gly, Cys or Thr

Belongs to the peptidase M24A family, Methionine aminopeptidase eukaryotic type 2 subfamily


This is Multisite-specific tRNA:(cytosine-C(5))-methyltransferase protein, from Baker's yeast, contains 684 amino acids, locates in Nucleus.

Methylates cytosine to m5C at several positions in different tRNAs and pre-tRNAs containing intron, Able to modify tRNAs at all four positions (34, 40, 48 and 49) at which m5C has been found in tRNAs, May be involved in ribosome biogenesis as its disruption leads to increased sensitivity to the antibiotic paromomycin

Belongs to the class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family, TRM4 subfamily


This is Ribonucleases P/MRP protein subunit POP8 protein, from Baker's yeast, contains 133 amino acids, locates in Nucleus.

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends, Also a component of RNase MRP, which cleaves pre-rRNA sequences


This is tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase protein, from Baker's yeast, contains 310 amino acids, is soluble, locates in Cytoplasm.

Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of tRNA(Phe), tRNA(Trp) and tRNA(Leu(UAA)), Requires TRM732 for methylation of the cytidine at position 32 and RTT10/TRM734 for methylation of the nucleotides at position 34 in substrate tRNAs, Lack of either of these modifications in tRNA(Phe) reduces formation of wybutosine from 1-methylguanosine at position 37

Belongs to the class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family, TRM7 subfamily


This is Vacuolar membrane protease protein, from Baker's yeast, contains 976 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May be involved in vacuolar sorting and osmoregulation


This is Increased sodium tolerance protein 2 protein, from Baker's yeast, contains 946 amino acids, is membrane-bound, locates in Cell membrane.

May be involved in ion homeostasis together with BTN1 or BTN2


This is Transcriptional regulatory protein RXT2 protein, from Baker's yeast, contains 430 amino acids, locates in Nucleus.

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


This is SRP-independent targeting protein 3 protein, from Baker's yeast, contains 188 amino acids, is membrane-bound, locates in Mitochondrion.

Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum, SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs (PubMed:27905431), Involved in inorganic phosphate uptake (PubMed:8709965), Also involved in telomere length regulation and maintenance (PubMed:16552446)


This is SWI5-dependent HO expression protein 3 protein, from Baker's yeast, contains 425 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease, Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell, Required for the delivery of cortical endoplasmic reticulum into the emerging bud


This is Exonuclease V, mitochondrial protein, from Baker's yeast, contains 585 amino acids, locates in Mitochondrion.

Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination, Releases dinucleotides as main products of catalysis, Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively


This is Mitofusin FZO1 protein, from Baker's yeast, contains 855 amino acids, is membrane-bound, locates in Mitochondrion.

Essential transmembrane GTPase, which mediates mitochondrial fusion (PubMed:9685359, PubMed:9786948, PubMed:10562274, PubMed:11266460, PubMed:15297626, PubMed:15760898, PubMed:16624808, PubMed:19812251, PubMed:21385840, PubMed:21502136, PubMed:23317502, PubMed:27253069), Fusion proceeds through several steps; first mitochondria are tethered together, then brought into close contact, followed by the formation of a docking ring around contact areas, and finally membrane fusion (PubMed:27253069), Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondrial morphology, which is balanced between fusion and fission, mediated by FZO1 and DNM1, respectively (PubMed:10562274), Functions antagonistically with DNM1 (PubMed:10562274), Probably acts by forming membrane contact sites that mediate mitochondrial membrane fusion (PubMed:27253069), Mitochondrial docking and fusion requires GTP hydrolysis (PubMed:15297626, PubMed:19812251, PubMed:27253069), Mitochondrial fusion promotes also increased lifespan

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, Mitofusin subfamily


This is Degradation in the endoplasmic reticulum protein 1 protein, from Baker's yeast, contains 211 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the endoplasmic reticulum-associated degradation (ERAD) pathway, Specifically required for the ERAD-L pathway which mediates the degradation of proteins with misfolded lumenal domains within the endoplasmic reticulum (ER), Facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with HRD1 (PubMed:32327568), Both proteins have lateral gates facing each other and distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568), Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1 (PubMed:32327568)


This is ATP-dependent clpX-like chaperone, mitochondrial protein, from Baker's yeast, contains 520 amino acids, is membrane-bound, locates in Mitochondrion.

ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase (HEM1), thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis, Up-regulates heme biosynthesis


This is RHO GTPase-activating protein RGD1 protein, from Baker's yeast, contains 666 amino acids, is soluble, locates in Cytoplasm.

GTPase activating protein of RHO3 and RHO4, Acts in concert with MID2 in cell integrity, which is functionally linked to the PKC pathway, Involved in various stress responses, Required at low pH for activation of the PKC pathway, Important during mating response


This is Alpha N-terminal protein methyltransferase 1 protein, from Baker's yeast, contains 232 amino acids, is soluble, locates in Cytoplasm.

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved, Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif, Responsible for the N-terminal methylation of the ribosomal proteins RPL12A, RPL12B, RPS25A and RPS25B

Belongs to the methyltransferase superfamily, NTM1 family


This is Cytoplasmic 60S subunit biogenesis factor REI1 protein, from Baker's yeast, contains 393 amino acids, has 3 C2H2-type Zinc finger, is soluble, locates in Cytoplasm.

Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit, Involved in the dissociation and recycling of other late pre-60S factors like ARX1, TIF6 and ALB1 before newly synthesized large ribosomal subunits enter translation, Cooperates with the co-chaperone JJJ1 in the release of the nuclear-export factor ARX1, May act redundantly with REH1 to directly promote a stabilizing structural rearrangement in cytoplasmic 60S subunit maturation independent on ARX1 recycling


This is DNA mismatch repair protein HSM3 protein, from Baker's yeast, contains 480 amino acids, is soluble, locates in Cytoplasm.

Involved in DNA mismatch repair in slow-growing cells, Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC)

Belongs to the proteasome subunit S5B/HSM3 family


This is RNA polymerase II-associated protein 1 protein, from Baker's yeast, contains 445 amino acids, is soluble, locates in Nucleus.

The PAF1 complex is a multifunctional complex, Involved in transcription initiation via genetic interactions with TATA-binding proteins, Involved in elongation, It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II, Also has a role in transcription-coupled histone modification, Required for activation of the RAD6/UBC2-BRE1 ubiquitin ligase complex, which ubiquitinates histone H2B to form H2BK123ub1, Also required for the methylation of histone H3 by the COMPASS complex to form H3K4me, by SET2 to form H3K36me, and by DOT1 to form H3K79me, RNA polymerase II associated protein important for transcription of a subset of genes, Required for both positive and negative regulation, Negatively regulates MAK16 expression, Also required for efficient CLN2 transcription in late G1 and may be involved in transcription of galactose-inducible genes


This is Coupling of ubiquitin conjugation to ER degradation protein 1 protein, from Baker's yeast, contains 203 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway, Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system, Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M), Has also a role in cold adaptation, perhaps through effects on sterol biosynthesis


This is Transcriptional regulatory protein SAP30 protein, from Baker's yeast, contains 201 amino acids, locates in Nucleus.


This is Coilin protein, from Human, contains 576 amino acids, locates in Nucleus.

Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs


This is Vitamin K-dependent gamma-carboxylase protein, from Human, contains 758 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide

Belongs to the vitamin K-dependent gamma-carboxylase family


This is RNA polymerase-associated protein LEO1 protein, from Baker's yeast, contains 464 amino acids, is soluble, locates in Nucleus.

The PAF1 complex is a multifunctional complex, Involved in transcription initiation via genetic interactions with TATA-binding proteins, Involved in elongation, It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II, Also has a role in transcription-coupled histone modification, Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B, Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2


This is GTP-binding protein YPT31/YPT8 protein, from Baker's yeast, contains 223 amino acids, is membrane-bound, locates in Golgi apparatus.

Required for protein transport in the secretory pathway, Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment, Plays a role in autophagy

Belongs to the small GTPase superfamily, Rab family


This is Ribose-phosphate pyrophosphokinase 2 protein, from Baker's yeast, contains 318 amino acids, is soluble, locates in Cytoplasm.

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis, Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)

Belongs to the ribose-phosphate pyrophosphokinase family


This is Serine/threonine-protein kinase RCK2 protein, from Baker's yeast, contains 610 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily


This is CTP synthase 2 protein, from Baker's yeast, contains 578 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen, Plays an important role in the regulation of phospholipid synthesis


This is Ribose-phosphate pyrophosphokinase 3 protein, from Baker's yeast, contains 320 amino acids, is soluble, locates in Cytoplasm.


This is Inosine-5'-monophosphate dehydrogenase 2 protein, from Baker's yeast, contains 523 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth, In contrast to the other IMPDH alleles IMD3 and IMD4, the enzymatic activity of IMD2 seems to be intrinsically drug resistant


This is Oxysterol-binding protein homolog 3 protein, from Baker's yeast, contains 996 amino acids, is soluble, locates in Cytoplasm.

Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes, Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol, Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:11238399, PubMed:15173322), May serve as a sensor of PI4P levels at PM-ER membrane contact site, regulating PI4P phosphatase SAC1 activity (PubMed:21295699), May be involved in ergosterol transport from the plasma membrane (PM) to the ER, however it does not bind sterols directly (PubMed:16585271, PubMed:23791945), Plays a role in the positive regulation of vesicular transport of ceramide from the ER to the Golgi, negatively regulating COPII-mediated ER export of cargos (PubMed:24213531)


This is ATP-dependent RNA helicase DBP8 protein, from Baker's yeast, contains 431 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites, Required for vegetative growth

Belongs to the DEAD box helicase family, DDX49/DBP8 subfamily


This is 6-phosphogluconate dehydrogenase, decarboxylating 1 protein, from Baker's yeast, contains 489 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

Belongs to the 6-phosphogluconate dehydrogenase family


This is Golgi SNAP receptor complex member 1 protein, from Baker's yeast, contains 223 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport, It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor, Rescues alpha-factor maturation defects


This is Oxysterol-binding protein homolog 7 protein, from Baker's yeast, contains 437 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

ipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes, Functions in phosphoinositide-coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transferring it between membranes through the cytosol, Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:15173322), Involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane, Specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the PM in exchange for PI4P, which is delivered to the ER-localized PI4P phosphatase SAC1 for degradation, Thus, by maintaining a PI4P gradient at the ER/PM interface, SAC1 drives PS transport (PubMed:23934110, PubMed:26206936), Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:26206936)


This is Nucleus export protein BRL1 protein, from Baker's yeast, contains 471 amino acids, is membrane-bound, locates in Nucleus.

Involved in mRNA and protein export from nucleus


This is Manganese transporter SMF2 protein, from Baker's yeast, contains 549 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

High-affinity manganese transporter involved in mobilizing manganese from vesicular stores iin conditions of low manganese ion concentrations


This is Proteasome-interacting protein CIC1 protein, from Baker's yeast, contains 376 amino acids, locates in Nucleus.

An adapter protein that specifically links the 26S proteasome to its substrate CDC4 which is one of the substrate recognition subunits of the SCF E3 ubiquitin ligase complex, Required for turnover of cell cycle regulatory proteins CDC4 and GRR1, Required for synthesis and nuclear export of 60S ribosomal subunits, Required for vegetative growth


This is Chromatin structure-remodeling complex protein RSC30 protein, from Baker's yeast, contains 883 amino acids, locates in Nucleus.

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall, Together with HTL1, LDB7, NPL6, RSC3 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity


This is Mediator of RNA polymerase II transcription subunit 6 protein, from Baker's yeast, contains 295 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 6 family


This is Ribonuclease P/MRP protein subunit RPP1 protein, from Baker's yeast, contains 293 amino acids, locates in Nucleus.

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends, Also a component of RNase MRP, which cleaves pre-rRNA sequences

Belongs to the eukaryotic/archaeal RNase P protein component 3 family


This is Ribosome-associated complex subunit SSZ1 protein, from Baker's yeast, contains 538 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state, RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain, SSZ1 is required for ZUO1 to function efficiently as a J-protein for SSB1/SSB2, Also involved in pleiotropic drug resistance by post-translational activation of transcription factor PDR1

Belongs to the heat shock protein 70 family


This is Protein phosphatase 2C homolog 7, mitochondrial protein, from Baker's yeast, contains 343 amino acids, locates in Mitochondrion.

Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:12220683, PubMed:23940037, PubMed:28076776, PubMed:30267671), Dephosphorylates and activates the ubiquinone biosynthesis protein CAT5/COQ7 (PubMed:23940037, PubMed:30267671), Also dephosphorylates CIT1 on 'Ser-462', which leads to its activation (PubMed:28076776)


This is Exosome complex protein LRP1 protein, from Baker's yeast, contains 184 amino acids, locates in Nucleus.

Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors, Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites, Required for activity of RRP6 in 7S pre-rRNA processing, Also has a role in 3'-processing of U4 and U5 small nuclear RNAs (snRNAs), Acts as a mRNA export factor, Mediates mRNA degradation upon UV irradiation, Maintains genome integrity where it is involved in both non-homologous end joining (NHEJ) and homologous recombination pathway repair of double strand DNA breaks, During NHEJ, required for joining 3'-overhanging ends, Also involved in telomere length regulation and maintenance


This is Pre-rRNA-processing protein IPI1 protein, from Baker's yeast, contains 334 amino acids, locates in Nucleus.

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA


This is Adenylyltransferase and sulfurtransferase UBA4 protein, from Baker's yeast, contains 440 amino acids, is soluble, locates in Cytoplasm.

Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln), Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1, Its N-terminus first activates URM1 as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus, The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1, Subsequently, a transient disulfide bond is formed, Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions, Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation, May also be involved in protein urmylation

In the N-terminal section; belongs to the HesA/MoeB/ThiF family, UBA4 subfamily


This is Protein BZZ1 protein, from Baker's yeast, contains 633 amino acids, is soluble, locates in Cytoplasm.

Plays a role in endocytosis and trafficking to the vacuole, Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress


This is E3 ubiquitin-protein ligase DMA1 protein, from Baker's yeast, contains 416 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes (PubMed:18202552), Involved in nutritional control of the cell cycle (PubMed:15319434), Targets the G1 cyclin PCL1 for destruction (PubMed:23264631), Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck (PubMed:15146058)


This is Protein TOM71 protein, from Baker's yeast, contains 639 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in MBF1-mediated mitochondrial morphogenesis


This is Meiosis-specific transcription factor NDT80 protein, from Baker's yeast, contains 627 amino acids, locates in Nucleus.

Transcription factor required for successful completion of meiosis and spore formation, Gets activated after completion of meiotic recombination at the end of prophase I, Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation, Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation


This is DNA-dependent metalloprotease WSS1 protein, from Baker's yeast, contains 269 amino acids, locates in Nucleus.

Metalloendopeptidase that acts selectively on DNA-binding proteins, DNA is needed to bring the protease and substrates together to enable proteolysis, Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde, Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin, DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways, May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites

Belongs to the peptidase M3 family, WSS1-like metalloprotease (WLM) subfamily


This is Aromatic amino acid aminotransferase 2 protein, from Baker's yeast, contains 513 amino acids, is soluble, locates in Cytoplasm.

General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways, Mainly involved in tryptophan degradation, Active with phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate and pyruvate as amino acceptors, Does not accept glutamate or 2-oxoglutarate as substrates, Also active with methionine, leucine, glutamine and kynurenine, Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors, Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA) with pyruvate as amino acceptor

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is Protein SVP26 protein, from Baker's yeast, contains 228 amino acids, is membrane-bound, locates in Golgi apparatus.

Plays a role in retention of a subset of membrane proteins in the early Golgi compartments, Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5


This is GPI transamidase component GPI16 protein, from Baker's yeast, contains 610 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the GPI transamidase complex, Involved in transfer of GPI to proteins


This is Nucleus-vacuole junction protein 1 protein, from Baker's yeast, contains 321 amino acids, is membrane-bound, locates in Nucleus.

Involved in the formation of nucleus-vacuole (NV) junctions during piecemeal microautophagy of the nucleus (PMN), NV junctions are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane, Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process, Acts also as an outer-nuclear membrane receptor for OSH1 and TSC13


This is U3 small nucleolar RNA-associated protein 9 protein, from Baker's yeast, contains 575 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)


This is Pre-rRNA-processing protein RIX1 protein, from Baker's yeast, contains 763 amino acids, locates in Nucleus.

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits (PubMed:11313466, PubMed:14759368, PubMed:15528184, PubMed:26619264), Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:26619264)


This is ER degradation-enhancing alpha-mannosidase-like protein 1 protein, from Baker's yeast, contains 796 amino acids, is soluble, locates in Endoplasmic reticulum.

Alpha-1,2-specific exomannosidase involved in endoplasmic reticulum-associated degradation (ERAD), Delivers misfolded glycoproteins to proteasomes, Forms a complex with PDI1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response

Belongs to the glycosyl hydrolase 47 family


This is Transcription factor SKN7 protein, from Baker's yeast, contains 622 amino acids, locates in Nucleus.

Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment, Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1, Also activated in response to oxidative stress, independent on the two-component regulatory system, Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes


This is Branched-chain-amino-acid aminotransferase, mitochondrial protein, from Baker's yeast, contains 393 amino acids, is soluble, locates in Mitochondrion.

Involved in the biosynthesis of the branched chain amino acids leucine, isoleucine, and valine, Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using branched chain amino acids (leucine, isoleucine, and valine) as the amino donors, Appears to be involved in the regulation of the transition from G1 to S phase in the cell cycle, High copy suppressor of a temperature-sensitive mutation in the ABC transporter, ATM1

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family


This is Inner kinetochore subunit CHL4 protein, from Baker's yeast, contains 458 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly


This is DNA mismatch repair protein MLH1 protein, from Baker's yeast, contains 769 amino acids, locates in Nucleus.

Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis, Component of different MutL heterodimers that form a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches, This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis, Plays a major role in maintaining the genetic stability of simple sequence repeats, the repair of heteroduplex sites present in meiotic recombination intermediates, and the promotion of meiotic crossing-over

Belongs to the DNA mismatch repair MutL/HexB family


This is Serine/arginine (SR)-type shuttling mRNA binding protein HRB1 protein, from Baker's yeast, contains 454 amino acids, locates in Nucleus.

Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14676199, PubMed:14769921, PubMed:24452287), Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded, On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export, On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287)


This is Manganese transporter SMF1 protein, from Baker's yeast, contains 575 amino acids, is membrane-bound, locates in Cell membrane.

High-affinity manganese transporter involved in manganese uptake from the extracellular environment, Contributes also to cellular accumulation of other divalent metal ions such as cadmium, cobalt, copper, iron and nickel


This is Axial budding pattern protein 2 protein, from Baker's yeast, contains 823 amino acids, is membrane-bound, locates in Cell membrane.

Required for haploid cells axial budding pattern, Acts as an anchor to help direct new growth components and/or polarity establishment components like the BUD5 GTP/GDP exchange factor to localize at the cortical axial budding site, Regulates septin organization in late G1 independently of its role in polarity-axis determination


This is Tethering factor for nuclear proteasome cut8 protein, from Fission yeast, contains 262 amino acids, locates in Nucleus.

Together with nucleoporin alm1, tethers the proteasome to the nuclear envelope (PubMed:28974540, PubMed:11084332, PubMed:16096059), Involved in ubiquitin-mediated protein degradation and facilitates the degradation of nuclear proteins like mitotic cyclin and cut2 (PubMed:11084332, PubMed:16096059), Required for normal progression of anaphase (PubMed:8065367, PubMed:11084332)


This is 25S rRNA (adenine(645)-N(1))-methyltransferase protein, from Baker's yeast, contains 392 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 645 in 25S rRNA, Required both for ribosomal 40S and 60S subunits biogenesis, Required for efficient pre-rRNA cleavage at site A2, Also involved in telomere length regulation and maintenance

Belongs to the methyltransferase superfamily, RRP8 family


This is Nuclear polyadenylated RNA-binding protein 3 protein, from Baker's yeast, contains 802 amino acids, is soluble, locates in Nucleus.

May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing, Binds to poly(A)+ RNA, Appears to act in the maintenance of CLN3 mRNA levels


This is Saccharopine dehydrogenase [NAD(+), L-lysine-forming] protein, from Baker's yeast, contains 373 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysine biosynthesis


This is Phosphatidylserine decarboxylase proenzyme 1, mitochondrial protein, from Baker's yeast, contains 500 amino acids, locates in Mitochondrion.

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer), Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (PubMed:8227017, PubMed:8407984, PubMed:17976194, PubMed:23124206, PubMed:25829489, PubMed:29290583), Phosphatidylethanolamine formed in the mitochondria is exported to other membranes to fullfill their requirements for PtdEtn (PubMed:8530379, PubMed:11294902, PubMed:29290583), Required for normal mitochondrial morphology and proper mitochondrial fusion during yeast mating (PubMed:23045528), Involved in lipid droplet biogenesis at the endoplasmic reticulum membrane (PubMed:34818062), Required for induction of mitophagy during nitrogen starvation (PubMed:30510114), Appears to play a specific role in supporting respiratory complex III activity (PubMed:30926815)

Belongs to the phosphatidylserine decarboxylase family, PSD-B subfamily, Eukaryotic type I sub-subfamily


This is Suppressor protein MPT5 protein, from Baker's yeast, contains 859 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein involved in post-transcriptional regulation, Negatively regulates expression of HO by binding to the 3'-UTR of HO mRNA, Predominantly binds to mRNAs encoding chromatin modifiers and spindle pole body components, Recognizes and binds to 5'-TGTAA[CT]A[AT]TA-3' in the 3'-UTR of target mRNAs, Multicopy suppressor of POP2 mutation, Required for high temperature growth


This is Small ribosomal subunit protein eS19 protein, from Human, contains 145 amino acids, locates in Nucleus.

Component of the small ribosomal subunit (PubMed:23636399), The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399), Required for pre-rRNA processing and maturation of 40S ribosomal subunits (PubMed:16990592), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Belongs to the eukaryotic ribosomal protein eS19 family


This is Dynamin-1 protein, from Mouse, contains 867 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP, Most probably involved in vesicular trafficking processes, Involved in receptor-mediated endocytosis (By similarity)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Exoribonuclease II, mitochondrial protein, from Baker's yeast, contains 969 amino acids, is soluble, locates in Mitochondrion.

Required for intron-independent turnover and processing of mitochondrial RNA, Participates in 3' mtRNA processing where it hydrolyzes single-stranded RNA or partially double-stranded RNA with 3' single-stranded tails


This is Protein Mpv17 protein, from Human, contains 176 amino acids, is membrane-bound, locates in Mitochondrion.

Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:25861990), Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance (PubMed:26760297), May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (By similarity)

Belongs to the peroxisomal membrane protein PXMP2/4 family


This is ATP-dependent RNA helicase DHH1 protein, from Baker's yeast, contains 506 amino acids, is soluble, locates in Cytoplasm.

ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1 (PubMed:11780629, PubMed:12032091, PubMed:11696541, PubMed:12730603, PubMed:15703442, PubMed:15706350), Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs (PubMed:15166134), May also have a role in translation and mRNA nuclear export (PubMed:12930949), Required for sporulation (PubMed:12930949), Blocks autophagy in nutrient-rich conditions by, at least partly, binding and repressing the expression of a set of ATG genes, including ATG3, ATG7, ATG8, ATG19, ATG20, ATG22 and SNX4/ATG24 (PubMed:26098573)

Belongs to the DEAD box helicase family, DDX6/DHH1 subfamily


This is Homocitrate dehydratase, mitochondrial protein, from Baker's yeast, contains 789 amino acids, locates in Mitochondrion.

Catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis

Belongs to the aconitase/IPM isomerase family


This is Elongation of fatty acids protein 1 protein, from Baker's yeast, contains 310 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of a microsomal membrane bound medium-chain fatty acid elongation system, which extends medium-chain-length fatty acids to long-chain fatty acids, Component of elongase I, which extends 12-16-carbon fatty acyl-CoAs such as lauroyl-CoA to 14-18-carbon fatty acids by incorporation of malonyl-CoA


This is COMPASS component SWD1 protein, from Baker's yeast, contains 426 amino acids, locates in Nucleus.

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation


This is (R,R)-butanediol dehydrogenase protein, from Baker's yeast, contains 382 amino acids, is soluble, locates in Cytoplasm.

NAD-dependent (R,R)-butanediol dehydrogenase which catalyzes oxidation of (R,R)-butane-2,3-diol to (3R)-acetoin, of meso-butanediol to (3S)-acetoin, and reduction of acetoin, Allows the use of 2,3-butanediol as an aerobic carbon source

Belongs to the zinc-containing alcohol dehydrogenase family


This is Flavin carrier protein 2 protein, from Baker's yeast, contains 783 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding

Belongs to the transient receptor potential (TRP) ion channel family


This is Mitochondrial Rho GTPase 1 protein, from Baker's yeast, contains 662 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial GTPase involved in mitochondrial trafficking, Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable)

Belongs to the mitochondrial Rho GTPase family


This is Glycine cleavage system H protein, mitochondrial protein, from Baker's yeast, contains 170 amino acids, locates in Mitochondrion.

The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine, The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)


This is Ribosome-interacting GTPase 1 protein, from Baker's yeast, contains 369 amino acids, is soluble, locates in Cytoplasm.

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family


This is Nucleolar complex protein 2 protein, from Baker's yeast, contains 710 amino acids, locates in Nucleus.

Involved in the intranuclear transport of ribosomal precursors


This is Glial cell line-derived neurotrophic factor protein, from Human, contains 211 amino acids, is soluble, locates in Extracellular.

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake

Belongs to the TGF-beta family, GDNF subfamily


This is Mitochondrial respiratory chain complexes assembly protein AFG3 protein, from Baker's yeast, contains 761 amino acids, is membrane-bound, locates in Mitochondrion.

Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins, The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes, Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides

In the C-terminal section; belongs to the peptidase M41 family


This is Eukaryotic initiation factor 4F subunit p150 protein, from Baker's yeast, contains 952 amino acids, is soluble, locates in Cytoplasm.

Component of the eIF4F complex, which interacts with the mRNA cap structure and serves as an initial point of assembly for the translation apparatus, Stimulates translation by interaction with polyadenylate-binding protein PAB1, bringing the 5'- and 3'-ends of the mRNA in proximity, The formation of this circular mRNP structure appears to be critical for the synergistic effects of the cap and the poly(A) tail in facilitating translation initiation, recycling of ribosomes, and mRNA stability, TIF4631 is probably essential when TIF4632 is missing

Belongs to the eukaryotic initiation factor 4G family


This is DNA damage-responsive transcriptional repressor RPH1 protein, from Baker's yeast, contains 796 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

Transcriptional repressor of photolyase PHR1, Recognizes and binds the sequence AG(4) in the upstream repressing sequence of PHR1, Derepresses PHR1 transcription when phosphorylated


This is Rab GDP-dissociation inhibitor protein, from Baker's yeast, contains 451 amino acids, is soluble, locates in Cytoplasm.

Regulates the GDP/GTP exchange reaction of SEC4 by inhibiting the dissociation of GDP from it, and the subsequent binding of GTP to SEC4, Plays an essential role in the yeast secretory pathway (PubMed:8157010), Extracts GDP-bound YPT7 from vacuolar membranes, antagonizing vacuolar membrane fusion (PubMed:11118206)


This is Pre-mRNA-splicing factor cdc5 protein, from Fission yeast, contains 757 amino acids, locates in Nucleus.

Involved in mRNA splicing and cell cycle control


This is D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3 protein, from Baker's yeast, contains 496 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate, Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate

Belongs to the FAD-binding oxidoreductase/transferase type 4 family


This is Chromatin modification-related protein EAF5 protein, from Baker's yeast, contains 279 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair


This is Enhancer of mRNA-decapping protein 3 protein, from Baker's yeast, contains 551 amino acids, is soluble, locates in Cytoplasm.

Stimulates decapping of both stable and unstable mRNA during mRNA decay, Does not affect nonsense-mediated mRNA decay, Required for normal P-body assembly


This is Golgi apyrase protein, from Baker's yeast, contains 630 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates, Has equal high activity toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate, Has no activity toward GMP, Required for Golgi glycosylation and cell wall integrity, Together with CDC55, required for adenovirus E4orf4 (early region 4 open reading frame 4) induced toxicity, the apyrase activity is not required for this function, Plays a role in sphingolipid synthesis


This is Nuclear GTP-binding protein NUG1 protein, from Baker's yeast, contains 520 amino acids, locates in Nucleus.

GTPase required for 60S ribosomal subunit export to the cytoplasm

Belongs to the TRAFAC class YlqF/YawG GTPase family


This is ABC transporter ATP-binding protein ARB1 protein, from Baker's yeast, contains 610 amino acids, locates in Cytoplasm.

ATPase that stimulates 40S and 60S ribosome biogenesis (PubMed:16260602), Also involved in ribosome-associated quality control (RQC) pathway, a pathway that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation: localizes to the ribosomal E-site and stimulates VMS1-dependent tRNA cleavage (PubMed:31189955)

Belongs to the ABC transporter superfamily, ABCF family, EF3 subfamily


This is Prolyl 3,4-dihydroxylase TPA1 protein, from Baker's yeast, contains 644 amino acids, locates in Nucleus.

Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-64' of small ribosomal subunit uS12 (RPS23A and RPS23B), thereby regulating protein translation termination efficiency, Part of a messenger ribonucleoprotein (mRNP) complex at the 3'-UTR of mRNAs, It associates specifically with components of the translation termination complex and is involved in both translation termination and in regulation of normal mRNA decay through translation termination-coupled poly(A) shortening


This is Vacuolar transporter chaperone complex subunit 1 protein, from Baker's yeast, contains 129 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Accessory subunit of the vacuolar transporter chaperone (VTC) complex, The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP, VTC exposes its catalytic domain VTC4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation (PubMed:19390046), The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen (PubMed:25315834, PubMed:19390046), PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase (PubMed:25315834), VTC1 contributes only 3 transmembrane domains to the complex (Probable), The VTC complex also plays a role in vacuolar membrane fusion (PubMed:10480897, PubMed:11102525, PubMed:11823419, PubMed:12584253), Required for SEC18/NSF activity in SNARE priming, membrane binding of LMA1 and V(0) trans-complex formation (PubMed:11823419)


This is Tyrosine-protein phosphatase 3 protein, from Baker's yeast, contains 928 amino acids, is soluble, locates in Cytoplasm.

Major phosphatase responsible for tyrosine dephosphorylation of MAP kinases FUS3 and HOG1 to inactivate their activity; it also has important roles, along with MSG5, in the inactivation of FUS3 following pheromone stimulation

Belongs to the protein-tyrosine phosphatase family, Non-receptor class subfamily


This is U3 small nucleolar RNA-associated protein 7 protein, from Baker's yeast, contains 554 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA


This is Monopolin complex subunit MAM1 protein, from Baker's yeast, contains 302 amino acids, locates in Nucleus.

Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis


This is Cytochrome c oxidase assembly protein COX15 protein, from Baker's yeast, contains 486 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the assembly of yeast cytochrome oxidase, Involved in the biosynthesis of heme A and the initial step in this pathway, the hydroxylation of heme O, is thought to be catalyzed by a three-component mono-oxygenase consisting of COX15, ferredoxin YAH1 and ferredoxin reductase ARH1


This is Negative cofactor 2 complex subunit alpha protein, from Baker's yeast, contains 142 amino acids, locates in Nucleus.

Component of the NC2 complex which represses RNA polymerase II transcription through binding to SPT15/TBP and thereby inhibiting the assembly of the preinitiation complex, The NC2 complex may also mediate transcriptional activation from TATA-driven promoters through association with SPT15/TBP


This is Zinc-dependent endopolyphosphatase protein, from Baker's yeast, contains 326 amino acids, locates in Lysosome/Vacuole.

Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths, Exclusively shows endopolyphosphatase activity, cleaving inside the polyP chain, Together with PPN1, responsible for a substantial fraction of polyphosphatase activity that is necessary to mobilize polyP stores in response to phosphate scarcity

Belongs to the metallophosphoesterase superfamily


This is Serine/threonine-protein phosphatase 4 regulatory subunit 3 protein, from Baker's yeast, contains 858 amino acids, locates in Nucleus.

Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process, Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint


This is PHO85 cyclin-7 protein, from Baker's yeast, contains 285 amino acids, is soluble, locates in Cytoplasm.

Cyclin partner of the cyclin-dependent kinase (CDK) PHO85, Together with cyclin PCL6, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility, The PCL7-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase, PCL7-PHO85 also phosphorylates MMR1 and YJL084C

Belongs to the cyclin family, PHO80 subfamily


This is Interferon alpha-inducible protein 27, mitochondrial protein, from Human, contains 122 amino acids, is membrane-bound, locates in Mitochondrion.

Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766), Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806), Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746), Also functions in TNFSF10-induced apoptosis (PubMed:24970806), May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340), May thereby play a role in the vascular response to injury (By similarity), In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077), May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077), Promotes also virus-induced pyroptosis by activating CASP3 in the mitochondria after 'Lys-6'-linked ubiquitination by TRIM21 (PubMed:36426955)


This is Elongation of fatty acids protein 3 protein, from Baker's yeast, contains 345 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of a microsomal membrane bound long-chain fatty acid elongation system, which produces the 20-26-carbon very long-chain fatty acids (VLCFA) from long-chain fatty acid precursors and is involved ceramide and inositol sphingolipid biosynthesis, Component of elongase III, which synthesizes 20-26-carbon fatty acids from 18-carbon-fatty acyl-CoA primers such as stearoyl-CoA by incorporation of malonyl-CoA (PubMed:9211877, PubMed:12684876), The enzymes active site faces the cytosol, whereas VLCFA length is determined by a lysine near the luminal end of transmembrane helix 6 (PubMed:17719544), Plays an important role in lipotoxic cell death induced by oleic acid through maintaining a balanced fatty acid composition in thr plasma membrane (PubMed:29458843), Affects plasma membrane H(+)-ATPase activity, May act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1, HXT3 and SNF3 (PubMed:8027068)


This is Mitochondrial respiratory chain complexes assembly protein YTA12 protein, from Baker's yeast, contains 825 amino acids, is membrane-bound, locates in Mitochondrion.

Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins, The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes, Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides


This is Phospholipid:diacylglycerol acyltransferase protein, from Baker's yeast, contains 661 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes triacylglycerol (TAG) formation by an acyl-CoA independent pathway, The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol (DAG), thus forming an sn-1-lysophospholipid (PubMed:10747858, PubMed:10829075, PubMed:32349126), The preferred acyl donors are phosphatidylethanolamine (PE) and phosphatidylcholine (PC), Also capable of using broad acyl donors such as phosphatidic acid (PA), phosphatidylserine (PS), phosphatidylglycerol (PG) and phosphatidylinositol (PI), as well as monogalactosyldiacylglycerol (MGDG), digalactosyldiacylglycerol (DGDG), and acyl-CoA, and it is more likely to use unsaturated acyl donors, As acyl acceptors, it prefers 1,2- over 1,3-diacylglycerol (DAG), Additionally, has esterification activity that can utilize methanol as acyl acceptor to generate fatty acid methyl esters (FAME) (PubMed:30706417), Can also utilize ceramide instead of DAG, acylating the ceramides by attaching a fatty acid to the hydroxy group on the first carbon atom of the long-chain base to produce 1-O-acylceramides (PubMed:22738231), Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains (PubMed:32349126), Relocates from the endoplasmic reticulum to a subdomain of the inner nuclear membrane upon nutrient starvation, where it provides a site of TAG synthesis, which is coupled with nuclear membrane remodeling (PubMed:31422915)

Belongs to the AB hydrolase superfamily, Lipase family


This is Mediator of RNA polymerase II transcription subunit 3 protein, from Baker's yeast, contains 397 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins, PGD1/MED3 is also involved in direct repeat recombination

Belongs to the mediator complex subunit 3 family


This is DNA replication complex GINS protein PSF2 protein, from Baker's yeast, contains 213 amino acids, locates in Nucleus.

Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery


This is Amino-acid acetyltransferase, mitochondrial protein, from Baker's yeast, contains 574 amino acids, locates in Mitochondrion.

N-acetylglutamate synthase involved in arginine biosynthesis


This is U3 small nucleolar RNA-associated protein 18 protein, from Baker's yeast, contains 594 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly


This is GPI ethanolamine phosphate transferase 2 protein, from Baker's yeast, contains 830 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Transfers ethanolamine phosphate to the GPI second mannose, Although not essential, addition of ethanolamine phosphate to the second mannose plays an important role in cell separation via the GPI-based modification of daughter-specific proteins

Belongs to the PIGG/PIGN/PIGO family, PIGG subfamily


This is Cyclin-dependent kinase inhibitor rum1 protein, from Fission yeast, contains 230 amino acids, locates in Nucleus.

Regulator of cell cycle G1 phase progression, Ensures the correct sequence of S phase and mitosis in the cell by acting as an inhibitor of the cdc2 mitotic kinase, Probably interacts with cdc2 to inhibit its action until the cell mass for Start is reached, Determines the length of the pre-Start G1 period and prevents mitosis from happening in early G1 cells, Required for maintaining pheromone-induced G1 arrest, Acts as an adapter protein since interaction with cdc13 promotes cyclin proteolysis during G1, Becomes a target for degradation at the G1/S phase transition, following phosphorylation by cig1-associated cdc2 at the G1/S phase transition


This is Iron-sulfur clusters transporter ATM1, mitochondrial protein, from Baker's yeast, contains 690 amino acids, is membrane-bound, locates in Mitochondrion.

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (PubMed:10406803, PubMed:31040179, PubMed:25006243), Hydrolyzes ATP (PubMed:25006243, PubMed:24604199), Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (PubMed:24604199, PubMed:25006243, PubMed:31040179)

Belongs to the ABC transporter superfamily, ABCB family, Heavy Metal importer (TC 3,A,1,210) subfamily


This is DNA-directed RNA polymerases I, II, and III subunit RPABC4 protein, from Baker's yeast, contains 70 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively, RNA polymerases are composed of mobile elements that move relative to each other, In Pol II, the core element with the central large cleft comprises RPB3, RBP10, RPB11, RPB12 and regions of RPB1 and RPB2 forming the active center

Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family


This is Homeobox protein extradenticle protein, from Fruit fly, contains 376 amino acids, locates in Nucleus.

Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity, Delimits the eye field and prevent inappropriate eye development, Required for proper localization of chordotonal organs within the peripheral nervous system