This is DNA mismatch repair protein PMS1 protein, from Baker's yeast, contains 873 amino acids, locates in Nucleus.

Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis, Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches, This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis, Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates

Belongs to the DNA mismatch repair MutL/HexB family


This is Carboxypeptidase M protein, from Human, contains 443 amino acids, is membrane-bound, locates in Cell membrane.

Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins, It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins


This is D(2) dopamine receptor protein, from Human, contains 443 amino acids, is membrane-bound, locates in Cell membrane.

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:21645528), Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity)

Belongs to the G-protein coupled receptor 1 family


This is Enoyl-CoA hydratase, mitochondrial protein, from Rat, contains 290 amino acids, is soluble, locates in Mitochondrion.

Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl-CoA) to the corresponding 3(S)-3-hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:7883013, PubMed:10074351), Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:7883013, PubMed:10074351), Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA), Can bind tiglyl-CoA (2-methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (By similarity), Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:7883013), At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)-hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl-CoA species (such as (3S)-hydroxyhexanoyl-CoA) (PubMed:10074351)

Belongs to the enoyl-CoA hydratase/isomerase family


This is Mitogen-activated protein kinase KSS1 protein, from Baker's yeast, contains 368 amino acids, locates in Cytoplasm.

Together with closely related FUS3, KSS1 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively, Phosphorylated KSS1 activates both pathways, whereas activated FUS3 activates the mating but suppresses the filamentation pathway, KSS1 activity is down-regulated by FUS3 during pheromone induction to prevent inappropriate activation of the filamentation pathway, During induction of filamentation, KSS1 activates the transcription factor STE12 resulting in its binding to and activation of filamentation specific genes, Non-activated KSS1 has a kinase-independent repressive effect on STE12 transcriptional activity, that is mediated by direct binding to STE12 and depends on the presence of DIG1 and DIG2, and that is required for the suppression of filamentation under normal growth conditions, SSN3/SRB10 contributes further to the suppression of filamentation under these conditions by reducing STE12 stability independent of KSS1, FUS3 can partially compensate for the lack of KSS1 but filamentation becomes constitutively induced at a low level in the absence of any signal, KSS1 phosphorylates STE7, STE5, FAR1, DIG1, DIG2, STE12, and SST2

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, MAP kinase subfamily, HOG1 sub-subfamily


This is Sorting assembly machinery 35 kDa subunit protein, from Baker's yeast, contains 329 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex


This is Glycylpeptide N-tetradecanoyltransferase protein, from Baker's yeast, contains 455 amino acids, is soluble, locates in Cytoplasm.

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins, Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates, Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4, Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6


This is Lambda-crystallin protein, from Rabbit, contains 319 amino acids, is soluble, locates in Cytoplasm.

Functions as crystallin in the rabbit eye lens, Has high L-gulonate 3-dehydrogenase activity, It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family


This is Vacuolar aminopeptidase 1 protein, from Baker's yeast, contains 514 amino acids, locates in Lysosome/Vacuole.

Resident vacuolar enzyme that catalyzes the removal of amino acids from the N-terminus of peptides and proteins, Also acts as the major cargo protein of the cytoplasm-to-vacuole targeting (Cvt) pathway, The precursor form of aminopeptidase 1 (prApe1) assembles into dodecamers and the propeptide mediates the aggregation of dodecamers into higher multimers, The multimers are then recognized via the propeptide by their receptor ATG19, and ATG19 further interacts with ATG11, which tethers the APE1-ATG19 complex to the pre-autophagosomal structure (PAS), The cargo-receptor complex (also Cvt complex) is selectively enwrapped by a double-membrane structure termed the Cvt vesicle under vegetative growth conditions and by a similar but larger double-membrane structure termed the autophagosome under nitrogen starvation conditions, The Cvt vesicle or the autophagosome fuses with the vacuolar membrane and release its content in the vacuolar lumen, In the vacuole, prApe1 is processed into mature aminopeptidase 1 (mApe1)


This is Cadherin-2 protein, from Mouse, contains 906 amino acids, is membrane-bound, locates in Cell membrane.

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell (PubMed:2762814, PubMed:11433297, PubMed:17988630, PubMed:9655503, PubMed:25253890), Cadherins may thus contribute to the sorting of heterogeneous cell types, Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463), Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (PubMed:26750727), Required for proper neurite branching, Required for pre- and postsynaptic organization (By similarity), CDH2 may be involved in neuronal recognition mechanism, In hippocampal neurons, may regulate dendritic spine density


This is Beta-mammal/insect toxin Ts1 protein, from Brazilian scorpion, contains 84 amino acids, is soluble, locates in Extracellular.

Voltage-gated sodium channels (Nav) gating-modifier, Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (PubMed:25862296) (Probable), Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements (PubMed:17698594, PubMed:19005548), Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity) (PubMed:17698594, PubMed:19005548, PubMed:25624450), Acts on almost all the Nav channels tested (mammalian Nav1,2/SCN2A, Nav1,3/SCN3A, Nav1,4/SCN4A, Nav1,5/SCN5A, Nav1,6/SCN8A, Nav1,9/SCN11A, and insect DmNav1) (PubMed:9048656, PubMed:17698594, PubMed:21670206, PubMed:24989851, PubMed:25862296, PubMed:31012002), Is highly active against both mammals and insects (PubMed:17118417, PubMed:21549737), Irreversibly modulates DmNav channels (PubMed:25862296), Other Ts1 activities have been studied, such as immunomodulation, antimicrobial activity or exocrine secretion (Probable), This toxin exhibits an antifungal activity against filamentous fungi (PubMed:28634472), In vitro, it has an important immunomodulatory effect on macrophages by stimulating the release of pro-inflammatory cytokines (PubMed:21549737), It also shows an activity in exocrine secretion in pancreas, stomach and adrenal gland (PubMed:1993690, PubMed:9611141, PubMed:10347806)

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family


This is Interferon gamma receptor 1 protein, from Human, contains 489 amino acids, is membrane-bound, locates in Cell membrane.

Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550), Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460, PubMed:7673114), Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2, In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1, Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123), STAT3 can also be activated in a similar manner although activation seems weaker, IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity)

Belongs to the type II cytokine receptor family


This is Interferon gamma receptor 1 protein, from Mouse, contains 477 amino acids, is membrane-bound, locates in Cell membrane.

Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456), Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:2530582, PubMed:2532365, PubMed:2137461, PubMed:2531896, PubMed:2530216), Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2, In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1, Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:19889125), STAT3 can also be activated in a similar manner although activation seems weaker (PubMed:15284232), IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (PubMed:15522878)


This is Signal peptidase complex catalytic subunit SEC11 protein, from Baker's yeast, contains 167 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:2644273, PubMed:7615509, PubMed:10206957, PubMed:11058593), Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity)


This is CD44 antigen protein, from Mouse, contains 778 amino acids, is membrane-bound, locates in Cell membrane.

Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment, Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection, Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:8343954, PubMed:25065622), Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (By similarity)


This is Potassium voltage-gated channel subfamily A member 3 protein, from Rat, contains 525 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the voltage-dependent potassium ion permeability of excitable membranes, Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient

Belongs to the potassium channel family, A (Shaker) (TC 1,A,1,2) subfamily, Kv1,3/KCNA3 sub-subfamily


This is Gamma-aminobutyric acid receptor subunit beta-1 protein, from Rat, contains 474 amino acids, is membrane-bound, locates in Cell membrane.

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain, Functions also as histamine receptor and mediates cellular responses to histamine, Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site, Functions as ligand-gated chloride channel

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Gamma-aminobutyric acid receptor (TC 1,A,9,5) subfamily, GABRB1 sub-subfamily


This is Acidic phospholipase A2 2 protein, from Indian cobra, contains 119 amino acids, is soluble, locates in Extracellular.

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group I subfamily, D49 sub-subfamily


This is Elastin protein, from Human, contains 786 amino acids, is soluble, locates in Extracellular.

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely, Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity)


This is Histatin-3 protein, from Human, contains 51 amino acids, is soluble, locates in Extracellular.

Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle), In addition, histatins exhibit antibacterial and antifungal activities, His3-(20-43)-peptide (histatin-5) is especially effective against C,albicans and C,neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P,gingivalis, In addition, His3-(20-43)-peptide is a potent inhibitor of metalloproteinases MMP2 and MMP9

Belongs to the histatin/statherin family


This is B-cell antigen receptor complex-associated protein beta chain protein, from Mouse, contains 228 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation, Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation


This is rRNA 2'-O-methyltransferase fibrillarin protein, from Baker's yeast, contains 327 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins, Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:2686980, PubMed:1825809, PubMed:12215523), Site specificity is provided by a guide RNA that base pairs with the substrate (PubMed:2686980, PubMed:1825809), Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (PubMed:2686980, PubMed:1825809), Involved in the biogenesis of the 18S rRNA (PubMed:2686980, PubMed:1825809), Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239)

Belongs to the methyltransferase superfamily, Fibrillarin family


This is Vascular endothelial growth factor A, long form protein, from Human, contains 395 amino acids, is soluble, locates in Extracellular.

Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth

Belongs to the PDGF/VEGF growth factor family


This is Glucan 1,3-beta-glucosidase protein, from Baker's yeast, contains 313 amino acids, is soluble, locates in Extracellular.

Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation, This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase

Belongs to the glycosyl hydrolase 17 family


This is Immunoglobulin lambda-like polypeptide 1 protein, from Human, contains 213 amino acids, has 1 Ig-like C1-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C1-type


This is Transcription factor 4 protein, from Human, contains 667 amino acids, locates in Nucleus.

Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif, Involved in the initiation of neuronal differentiation, Activates transcription by binding to the E box (5'-CANNTG-3'), Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity), Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'


This is Replication protein A 32 kDa subunit protein, from Human, contains 270 amino acids, locates in Nucleus.

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress, It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism, Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage, In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation, Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response, It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage, Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair, Also plays a role in base excision repair (BER) probably through interaction with UNG, Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage, May also play a role in telomere maintenance

Belongs to the replication factor A protein 2 family


This is Solute carrier family 25 member 3 protein, from Rat, contains 356 amino acids, is membrane-bound, locates in Mitochondrion.

Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity), Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity), Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (By similarity), May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (PubMed:18667415)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Uricase protein, from Fruit fly, contains 352 amino acids, locates in Peroxisome.

Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin


This is Cyclic AMP-responsive element-binding protein 1 protein, from Human, contains 327 amino acids, locates in Nucleus.

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters, Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation, Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells


This is Phosphatidylcholine-sterol acyltransferase protein, from Mouse, contains 438 amino acids, is soluble, locates in Extracellular.

Central enzyme in the extracellular metabolism of plasma lipoproteins, Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:19065001), The cholesterol ester is then transported back to the liver, Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels (PubMed:19065001), Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins (PubMed:19065001), Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:19065001), Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107), Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:10393212), Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity), Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity)

Belongs to the AB hydrolase superfamily, Lipase family


This is Intron Large complex component GCFC2 protein, from Human, contains 781 amino acids, is soluble, locates in Nucleus.

Involved in pre-mRNA splicing through regulating spliceosome C complex formation (PubMed:24304693), May play a role during late-stage splicing events and turnover of excised introns (PubMed:24304693)


This is Endoplasmic reticulum chaperone BiP protein, from Baker's yeast, contains 682 amino acids, is soluble, locates in Endoplasmic reticulum.

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER, Is required for secretory polypeptide translocation, May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis

Belongs to the heat shock protein 70 family


This is E-selectin protein, from Human, contains 610 amino acids, is membrane-bound, locates in Cell membrane.

Cell-surface glycoprotein having a role in immunoadhesion, Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1, May have a role in capillary morphogenesis


This is General transcriptional corepressor TUP1 protein, from Baker's yeast, contains 713 amino acids, locates in Nucleus.

Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes, May also be involved in the derepression of at least some target genes, The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1, The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex


This is Guanine nucleotide exchange factor subunit RGP1 protein, from Baker's yeast, contains 663 amino acids, locates in Golgi apparatus.


This is Mitogen-activated protein kinase FUS3 protein, from Baker's yeast, contains 353 amino acids, locates in Cytoplasm.

Together with closely related KSS1, FUS3 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively, Phosphorylated FUS3 activates the mating but suppresses the filamentation pathway, whereas activated KSS1 activates both pathways, Pheromone-activated FUS3 functions by inhibiting the binding of the transcriptional activator STE12 to filamentation specific genes while inducing its binding to and activity at mating specific genes, Non-activated FUS3 has a repressive effect on STE12 transcriptional activity, KSS1 can partially compensate for the lack of FUS3 but mating efficiency is reduced and the filamentation program is partially activated upon pheromone signaling, FUS3 phosphorylates STE7, STE5, FAR1, DIG1, DIG2 and STE12

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily


This is SPARC protein, from Rat, contains 301 amino acids, is soluble, locates in Extracellular.

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines, Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes, There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity


This is Zinc finger protein 12 protein, from Human, contains 697 amino acids, has 15 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Zinc finger protein 16 protein, from Human, contains 682 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 15 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

Acts as a transcriptional activator, Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase, Involved in both the hemin- and phorbol myristate acetate (PMA)-induced erythroid and megakaryocytic differentiation, respectively, Also plays a role as an inhibitor of cell apoptosis


This is Zinc finger protein 24 protein, from Human, contains 368 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor required for myelination of differentiated oligodendrocytes, Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state, In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle, Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity), Has transcription repressor activity in vitro


This is Large ribosomal subunit protein eL8A protein, from Baker's yeast, contains 256 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL8 family


This is Transmembrane protein 11, mitochondrial protein, from Human, contains 192 amino acids, is membrane-bound, locates in Mitochondrion.

Plays a role in mitochondrial morphogenesis


This is Heat shock-related 70 kDa protein 2 protein, from Mouse, contains 633 amino acids, is soluble, locates in Cytoplasm.

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes, Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation, This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones, The affinity for polypeptides is regulated by its nucleotide bound state, In the ATP-bound form, it has a low affinity for substrate proteins, However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins, It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (By similarity), Plays a role in spermatogenesis (PubMed:24557841), In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841)


This is Aspartate aminotransferase, cytoplasmic protein, from Human, contains 413 amino acids, is soluble, locates in Cytoplasm.

Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944), Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system, Acts as a scavenger of glutamate in brain neuroprotection, The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis, Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide, Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST), Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain, In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456)

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is Lipopolysaccharide-binding protein protein, from Rabbit, contains 482 amino acids, is soluble, locates in Extracellular.

Plays a role in the innate immune response (PubMed:2402637), Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:2427635), Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity), Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:2402637)

Belongs to the BPI/LBP/Plunc superfamily, BPI/LBP family


This is Malate dehydrogenase, mitochondrial protein, from Baker's yeast, contains 334 amino acids, is soluble, locates in Mitochondrion.

Belongs to the LDH/MDH superfamily, MDH type 1 family


This is Adenylyl cyclase-associated protein protein, from Baker's yeast, contains 526 amino acids, is soluble, locates in Cytoplasm.

The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras, The C-terminal domain is required for normal cellular morphology and growth control


This is 4-aminobutyrate aminotransferase protein, from Baker's yeast, contains 471 amino acids, is soluble, locates in Cytoplasm.

Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source and for oxidative stress tolerance, Deaminates GABA to succinate semialdehyde, which in turn is converted to succinate by the succinate-semialdehyde dehydrogenase UGA2, Cannot transaminate beta-alanine (BAL)

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family


This is Potassium voltage-gated channel subfamily A member 6 protein, from Human, contains 529 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698), The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698), Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity), Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity), Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305)

Belongs to the potassium channel family, A (Shaker) (TC 1,A,1,2) subfamily, Kv1,6/KCNA6 sub-subfamily


This is Potassium voltage-gated channel subfamily A member 6 protein, from Rat, contains 530 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient, The channel alternates between opened and closed conformations in response to the voltage difference across the membrane, Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:1993474, PubMed:15618540), Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (Probable), Homotetrameric channels display rapid activation and slow inactivation (PubMed:1993474)


This is Erythroid transcription factor protein, from Mouse, contains 413 amino acids, has 2 GATA-type Zinc finger, locates in Nucleus.

GATA-type

GATA-type

Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development, It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells, Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (By similarity)


This is Mu-ctenitoxin-Pn1a protein, from Brazilian armed spider, contains 112 amino acids, is soluble, locates in Extracellular.

Reversible inhibitor of neuronal sodium channels (Nav1,2/ SCN2A) that binds in proximity to site 1 and displays increasing affinity as the membrane potential is depolarized, Induces excitatory symptoms and spastic paralysis in mice

Belongs to the neurotoxin 04 (omega-agtx) family, 02 (Tx1) subfamily


This is Elongation factor Tu, chloroplastic protein, from Mouse-ear cress, contains 476 amino acids, is soluble, locates in Plastid.

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily


This is Probable ATP-dependent RNA helicase DDX5 protein, from Human, contains 614 amino acids, locates in Nucleus.

Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner, Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10, The rate of ATP hydrolysis is highly stimulated by single-stranded RNA, Involved in transcriptional regulation; the function is independent of the RNA helicase activity, Transcriptional coactivator for androgen receptor AR but probably not ESR1, Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation, Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis, Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation, Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1, As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms

Belongs to the DEAD box helicase family, DDX5/DBP2 subfamily


This is X-box-binding protein 1 protein, from Human, contains 261 amino acids, locates in Cytoplasm.

Functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE), Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945), Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity), Induces phospholipid biosynthesis and ER expansion (PubMed:15466483), Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610), Promotes umbilical vein EC apoptosis and atherosclerotisis development in a caspase-dependent signaling pathway, and contributes to VEGF-induced EC proliferation and angiogenesis in adult tissues under ischemic conditions (PubMed:19416856, PubMed:23529610), Involved in the regulation of endostatin-induced autophagy in EC through BECN1 transcriptional activation (PubMed:23184933), Plays a role as an oncogene by promoting tumor progression: stimulates zinc finger protein SNAI1 transcription to induce epithelial-to-mesenchymal (EMT) transition, cell migration and invasion of breast cancer cells (PubMed:25280941), Involved in adipocyte differentiation by regulating lipogenic gene expression during lactation, Plays a role in the survival of both dopaminergic neurons of the substantia nigra pars compacta (SNpc), by maintaining protein homeostasis and of myeloma cells, Increases insulin sensitivity in the liver as a response to a high carbohydrate diet, resulting in improved glucose tolerance, Improves also glucose homeostasis in an ER stress- and/or insulin-independent manner through both binding and proteasome-induced degradation of the transcription factor FOXO1, hence resulting in suppression of gluconeogenic genes expression and in a reduction of blood glucose levels, Controls the induction of de novo fatty acid synthesis in hepatocytes by regulating the expression of a subset of lipogenic genes in an ER stress- and UPR-independent manner (By similarity), Associates preferentially to the HDAC3 gene promoter region in a disturbed flow-dependent manner (PubMed:25190803), Binds to the BECN1 gene promoter region (PubMed:23184933), Binds to the CDH5/VE-cadherin gene promoter region (PubMed:19416856), Binds to the ER stress response element (ERSE) upon ER stress (PubMed:11779464), Binds to the 5'-CCACG-3' motif in the PPARG promoter (By similarity)


This is Proliferating cell nuclear antigen protein, from Fruit fly, contains 260 amino acids, locates in Nucleus.

Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility


This is Proliferating cell nuclear antigen protein, from Mouse, contains 261 amino acids, locates in Nucleus.

Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand, Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities, Has to be loaded onto DNA in order to be able to stimulate APEX2, Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways, Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity)


This is Transcription factor PU.1 protein, from Human, contains 270 amino acids, locates in Nucleus.

Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites, Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726), Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity), Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors, FCER1A transactivation is achieved in cooperation with GATA1 (By similarity), May be particularly important for the pro- to pre-B cell transition (PubMed:33951726), Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726), In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity)


This is Tyrosine-protein phosphatase non-receptor type 1 protein, from Human, contains 435 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response, Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK, May play an important role in CKII- and p60c-src-induced signal transduction cascades, May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion, May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET

Belongs to the protein-tyrosine phosphatase family, Non-receptor class 1 subfamily


This is Guanine nucleotide-binding protein alpha-1 subunit protein, from Mouse-ear cress, contains 383 amino acids, is membrane-bound, locates in Cell membrane.

Exhibits a fast rate of basal nucleotide exchange, Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems, Together with GCR1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate (IP(3)) as a second messenger, Promotes abscisic acid (ABA) responses in guard cells, Involved in the blue light (BL) signaling, Together with GCR1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings, Modulates root architecture (e,g, lateral root formation), Negatively regulated by RGS1, In collaboration with CAND2/PMTR1, regulates the melatonin-mediated stomatal closure involving H(2)O(2) and Ca(2+) signals (PubMed:29702752)


This is Alpha-2B adrenergic receptor protein, from Human, contains 450 amino acids, is membrane-bound, locates in Cell membrane.

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins, The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine, For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol

Belongs to the G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2B sub-subfamily


This is Alpha-actinin, sarcomeric protein, from Fruit fly, contains 924 amino acids, is soluble, locates in Cytoplasm.

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures, This is a bundling protein


This is Cytochrome P450 7A1 protein, from Rat, contains 503 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:1694852, PubMed:2335522), Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:1694852, PubMed:2335522), Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis, Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:1694852, PubMed:2335522), 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol, Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity)


This is Defective chorion protein, FC106 isoform protein, from Fruit fly, contains 950 amino acids, is soluble, locates in Extracellular.

Required for proper assembly of the eggshell


This is Transcription factor Jra protein, from Fruit fly, contains 289 amino acids, locates in Nucleus.

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:1696724, PubMed:2116361), Plays a role in dorsal closure (PubMed:9224723)

Belongs to the bZIP family, Jun subfamily


This is Mitochondrial distribution and morphology protein 10 protein, from Baker's yeast, contains 493 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria, Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange, MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex), Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins, Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins, May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway, Plays a role in mitochondrial morphology and in the inheritance of mitochondria


This is Calreticulin protein, from Rat, contains 416 amino acids, is soluble, locates in Endoplasmic reticulum.

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle, This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER, Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity), Involved in maternal gene expression regulation, May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity), Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)


This is Phosphatidylcholine-sterol acyltransferase protein, from Rat, contains 440 amino acids, is soluble, locates in Extracellular.

Central enzyme in the extracellular metabolism of plasma lipoproteins, Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs), The cholesterol ester is then transported back to the liver, Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels, Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins, Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity), Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107, PubMed:14636062), Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity), Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity), Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity)


This is Potassium-transporting ATPase subunit beta protein, from Pig, contains 290 amino acids, is membrane-bound, locates in Cell membrane.

The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells, Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity), Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2), Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (PubMed:29618813, PubMed:19387495)

Belongs to the X(+)/potassium ATPases subunit beta family


This is SWI/SNF chromatin-remodeling complex subunit SNF5 protein, from Baker's yeast, contains 905 amino acids, locates in Nucleus.

Involved in transcriptional activation, Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is Gamma-aminobutyric acid receptor subunit gamma-2 protein, from Human, contains 475 amino acids, is membrane-bound, locates in Cell membrane.

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2538761, PubMed:29950725), Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750, PubMed:27864268), The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity), The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750), The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity), Functions also as histamine receptor and mediates cellular responses to histamine (By similarity)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Gamma-aminobutyric acid receptor (TC 1,A,9,5) subfamily, GABRG2 sub-subfamily


This is Gamma-aminobutyric acid receptor subunit gamma-2 protein, from Rat, contains 466 amino acids, is membrane-bound, locates in Cell membrane.

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:2561970), Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity), The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity), The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity), Functions also as histamine receptor and mediates cellular responses to histamine (By similarity)


This is Cationic amino acid transporter 2 protein, from Mouse, contains 657 amino acids, is membrane-bound, locates in Cell membrane.

Functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

Belongs to the amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2,A,3,3) family


This is Cyclic AMP-dependent transcription factor ATF-3 protein, from Human, contains 181 amino acids, locates in Nucleus.

Stress-induced isoform, counteracts the transcriptional repression of isoform 1

Belongs to the bZIP family, ATF subfamily


This is Guanine nucleotide-binding protein G(o) subunit alpha protein, from Mouse, contains 354 amino acids, is membrane-bound, locates in Cell membrane.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems, Stimulated by RGS14, The G(o) protein function is not clear

Belongs to the G-alpha family, G(i/o/t/z) subfamily


This is Carnitine O-palmitoyltransferase 2, mitochondrial protein, from Rat, contains 658 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites, Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion, Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters

Belongs to the carnitine/choline acetyltransferase family


This is DNA repair protein XRCC1 protein, from Human, contains 633 amino acids, locates in Nucleus.

Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403), Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:34102106, PubMed:34811483, PubMed:28002403), Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483)


This is Potassium voltage-gated channel subfamily A member 5 protein, from Rat, contains 602 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient, The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2361015, PubMed:15618540), Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:15618540), Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:15618540), Homotetrameric channels display rapid activation and slow inactivation, May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity)

Belongs to the potassium channel family, A (Shaker) (TC 1,A,1,2) subfamily, Kv1,5/KCNA5 sub-subfamily


This is ADP-ribosylation factor 2 protein, from Baker's yeast, contains 181 amino acids, locates in Golgi apparatus.

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus

Belongs to the small GTPase superfamily, Arf family


This is Basic endochitinase B protein, from Mouse-ear cress, contains 335 amino acids, locates in Lysosome/Vacuole.

Defense against chitin-containing fungal pathogens, Seems particularly implicated in resistance to jasmonate-inducing pathogens such as A,brassicicola, In vitro antifungal activity against T,reesei, but not against A,solani, F,oxysporum, S,sclerotiorum, G,graminis and P,megasperma

Belongs to the glycosyl hydrolase 19 family, Chitinase class I subfamily


This is 5-hydroxytryptamine receptor 1A protein, from Rat, contains 422 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various drugs and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways, Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores, Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism, Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior, Plays a role in the response to anxiogenic stimuli

Belongs to the G-protein coupled receptor 1 family, 5-hydroxytryptamine receptor subfamily, HTR1A sub-subfamily


This is DNA-directed RNA polymerase II subunit RPB3 protein, from Human, contains 275 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity)

Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family


This is DNA-directed RNA polymerases I, II, and III subunit RPABC1 protein, from Human, contains 210 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively, Pol II is the central component of the basal RNA polymerase II transcription machinery, Pols are composed of mobile elements that move relative to each other, In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template, Seems to be the major component in this process (By similarity)

Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family


This is Vitelline membrane protein 15a-2 protein, from Yellowfever mosquito, contains 97 amino acids, is soluble, locates in Extracellular.

Has an oostatic activity, Inhibits trypsin biosynthesis in the midgut epithelial cells which indirectly reduces the vitellogenin concentration in the hemolymph resulting in inhibition of oocyte development

Belongs to the vitelline membrane protein family


This is Glutathione hydrolase 1 proenzyme protein, from Human, contains 569 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the gamma-glutamyltransferase family


This is Coagulation factor IX protein, from Dog, contains 452 amino acids, is soluble, locates in Extracellular.

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa


This is Retinoic acid receptor RXR-alpha protein, from Human, contains 462 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042), Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:28167758, PubMed:17761950, PubMed:16107141, PubMed:18800767, PubMed:19167885), The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758), The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260), In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566), On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:9267036), Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580), The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580), The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690), Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758), Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758), May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776), Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675), Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649), Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632)

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Heat shock protein 60, mitochondrial protein, from Baker's yeast, contains 572 amino acids, is soluble, locates in Mitochondrion.

May participate in assembly and/or disassembly of proteins imported into the mitochondrion, HSP60 are ATPases and have affinity for unfolded proteins

Belongs to the chaperonin (HSP60) family


This is Ribosome-binding factor PSRP1, chloroplastic protein, from Spinach, contains 302 amino acids, is soluble, locates in Plastid.

Ribosome-binding factor involved in light- and temperature-dependent control of protein synthesis, Interacts with 16S sRNA nucleotides at the A-site and P-site, where it protects the decoding center and inhibits translation by preventing tRNA binding, Stabilizes 70S ribosomes against dissociation, May be recycled by the combined action of ribosome-recycling factor (RRF) and EF-G

Belongs to the HPF/YfiA ribosome-associated protein family, Long plastid HPF subfamily


This is 37S ribosomal protein YMR-31, mitochondrial protein, from Baker's yeast, contains 123 amino acids, locates in Mitochondrion.


This is Mannose-binding protein A protein, from Rat, contains 238 amino acids, is soluble, locates in Extracellular.

Calcium-dependent lectin (PubMed:1436090, PubMed:9033386, PubMed:11850428), Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (PubMed:3584121), Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity)


This is Homeotic protein distal-less protein, from Fruit fly, contains 327 amino acids, locates in Nucleus.

Transcription factor that plays a role in larval and adult appendage development, Specifies the identity of ventral appendages (including legs and antennae) and suppresses dorsal appendage development, Involved in patterning the distal-proximal limb axis, May control the adhesive properties of cells during limb morphogenesis, Also has a secondary role in the normal patterning of the wing margin


This is Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 protein, from Baker's yeast, contains 876 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing, Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction, Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing, Capable of hydrolyzing nucleoside triphosphates in the presence of single-stranded RNAs such as poly(U)

Belongs to the DEAD box helicase family, DEAH subfamily


This is Citrate synthase 4, mitochondrial protein, from Mouse-ear cress, contains 474 amino acids, is soluble, locates in Mitochondrion.


This is LIM/homeobox protein ceh-14 protein, from Caenorhabditis elegans, contains 351 amino acids, locates in Nucleus.

Probable transcription factor, modulating expression of helix-loop-helix protein mbr-1 and homeobox protein ceh-63, perhaps acting in concert with ceh-63 (PubMed:22207033), Binds to a motif including the sequence 5'-CTAAT-3' in regulatory promoter elements (PubMed:25614239), Confers thermosensory function to neurons (PubMed:10774727), Required for correct AFD-mediated thermotaxis (PubMed:10774727), In concert with homeobox protein ttx-1, perhaps as components in a complex, specifies identity of AFD neurons, acting by synergistically regulating receptor-type guanylyl cyclase gcy-8, gcy-18 and other genes (PubMed:25614239), Involved in postembryonic differentiation of the ALA neuron, and regulation of genes that contribute to behavioral quiescence, a sleep-like behavior mediated by ALA (PubMed:20501595), Regulates its own expression and also that of homeodomain ceh-17, together forming an autoregulatory loop in the ALA neuron (PubMed:20501595, PubMed:26096732), Required for initial pathfinding of the ALA axons, but largely dispensable for axon migration (PubMed:20501595), Involved in regulating postembryonic axon maintenance in the ventral nerve cord, acting in concert with LIM homeobox protein lim-6, via modulation of expression of immunoglobulin domain zig genes in the interneuron PVT (PubMed:12490565), Plays a role in controlling the peptidergic identity of the BDU neurons, regulating expression of flp-10, nlp-1, and nlp-15, thereby modulating the harsh touch response (PubMed:26096732)


This is Ras-related protein Rab-6A protein, from Human, contains 208 amino acids, is membrane-bound, locates in Golgi apparatus.

Regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER) (PubMed:25962623), Has a low GTPase activity (PubMed:25962623), Recruits VPS13B to the Golgi membrane (PubMed:25492866), Plays a role in neuron projection development (Probable)

Belongs to the small GTPase superfamily, Rab family


This is G protein alpha i subunit protein, from Fruit fly, contains 355 amino acids, is membrane-bound, locates in Cell membrane.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems, Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord


This is Metalloproteinase inhibitor 1 protein, from Bovine, contains 207 amino acids, is soluble, locates in Extracellular.

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor, Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16, Does not act on MMP14, Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1, Plays a role in integrin signaling

Belongs to the protease inhibitor I35 (TIMP) family


This is DNA-directed RNA polymerases I, II, and III subunit RPABC3 protein, from Baker's yeast, contains 146 amino acids, locates in Nucleus.

DNA-dependent RNA polymerases catalyze the transcription, of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively

Belongs to the eukaryotic RPB8 RNA polymerase subunit family


This is ATP-dependent RNA helicase DBP3 protein, from Baker's yeast, contains 523 amino acids, locates in Nucleus.

ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis, Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5,8S rRNAs

Belongs to the DEAD box helicase family, DDX5/DBP2 subfamily


This is ATP-dependent RNA helicase HCA4 protein, from Baker's yeast, contains 770 amino acids, locates in Nucleus.

ATP-dependent RNA helicase required for ribosome biogenesis, Involved in the release of U14 snoRNA in pre-ribosomal complexes, Required for pre-rRNA cleavage at site A2

Belongs to the DEAD box helicase family, DDX10/DBP4 subfamily


This is Neurotensin receptor type 1 protein, from Rat, contains 424 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:23051748, PubMed:24453215, PubMed:26205105), Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system, Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity)

Belongs to the G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR1 sub-subfamily


This is Interleukin-11 protein, from Human, contains 199 amino acids, is soluble, locates in Extracellular.

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578), Also promotes the proliferation of hepatocytes in response to liver damage, Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066), Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3, The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168)


This is Hepatocyte nuclear factor 1-alpha protein, from Human, contains 631 amino acids, locates in Nucleus.

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity), Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642), Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity)


This is Alpha-1-antitrypsin-related protein protein, from Human, contains 421 amino acids, locates in Endoplasmic reticulum.


This is 5-hydroxytryptamine receptor 1 protein, from Fruit fly, contains 564 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling activates adenylate cyclase activity

Belongs to the G-protein coupled receptor 1 family, 5-hydroxytryptamine receptor subfamily


This is Polyadenylate-binding protein 1-A protein, from African clawed frog, contains 633 amino acids, is soluble, locates in Cytoplasm.

Binds the poly(A) tail of mRNA, Prevents mRNA deadenylation and confers poly(A) stability, Binds to N6-methyladenosine (m6A)-containing mRNAs (By similarity), Stimulates the translation of mRNAs to which it is bound, acting, at least in part, with dazl

Belongs to the polyadenylate-binding protein type-1 family


This is Chaperonin 60 subunit beta 1, chloroplastic protein, from Mouse-ear cress, contains 600 amino acids, is soluble, locates in Plastid.

Binds RuBisCO small and large subunits and is implicated in the assembly of the enzyme oligomer, Involved in protein assisted folding, Required for proper plastid division


This is Guanine nucleotide-binding protein G(q) subunit alpha protein, from Mouse, contains 359 amino acids, is membrane-bound, locates in Nucleus.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:9687499), Required for platelet activation (PubMed:9296496), Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (PubMed:20624888), Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (PubMed:17938235), Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (By similarity), Together with GNA11, required for heart development (PubMed:9687499)

Belongs to the G-alpha family, G(q) subfamily


This is Pre-mRNA-processing ATP-dependent RNA helicase PRP5 protein, from Baker's yeast, contains 849 amino acids, locates in Nucleus.

ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing, Catalyzes an ATP-dependent conformational change of U2 snRNP, Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA

Belongs to the DEAD box helicase family, DDX46/PRP5 subfamily


This is Fumarate reductase 2 protein, from Baker's yeast, contains 501 amino acids, locates in Mitochondrion.

Irreversibly catalyzes the reduction of fumarate to succinate, Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth, Involved in maintaining redox balance during oxygen deficiency conditions, Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2)

Belongs to the FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily


This is fMet-Leu-Phe receptor protein, from Human, contains 350 amino acids, is membrane-bound, locates in Cell membrane.

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520), Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802), This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456), Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685), Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802)

Belongs to the G-protein coupled receptor 1 family


This is Ribonucleoside-diphosphate reductase large chain 1 protein, from Baker's yeast, contains 888 amino acids, is soluble, locates in Cytoplasm.

Provides the precursors necessary for DNA synthesis, Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Belongs to the ribonucleoside diphosphate reductase large chain family


This is Transcription factor kayak, isoforms A/B/F protein, from Fruit fly, contains 755 amino acids, locates in Nucleus.

Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3', May play a role in the function or determination of a particular subset of cells in the developing embryo, It is able to carry out its function either independently of or in conjunction with Jra

Belongs to the bZIP family, Fos subfamily


This is Beta-enolase protein, from Mouse, contains 434 amino acids, is soluble, locates in Cytoplasm.

Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate, Appears to have a function in striated muscle development and regeneration


This is Y-box-binding protein 2-A protein, from African clawed frog, contains 336 amino acids, is soluble, locates in Cytoplasm.

Has a dual function in oocytes: as a DNA-binding protein, binds to the Y-box sequence (CTGATTGGCCAA) in the promoters of target genes to stimulate transcription, May also function at CCAAT-containing promoters that lack the consensus Y-box sequence, Also binds mRNA to promote accumulation of the transcripts it contributes to produce


This is Vacuolar protein sorting-associated protein 1 protein, from Baker's yeast, contains 704 amino acids, is soluble, locates in Cytoplasm.

Essential for protein sorting in meiotic cell division of S,cerevisiae; it binds microtubules, Could also be involved in microtubule-associated motility, Necessary for membrane protein retention in a late Golgi compartment, Interacts with the MVP1 protein

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Pyrophosphate-energized vacuolar membrane proton pump protein, from Mung bean, contains 766 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Proton-translocating inorganic pyrophosphatase that contributes to the transtonoplast (from cytosol to vacuole lumen) H(+)-electrochemical potential difference, It establishes a proton gradient of similar and often greater magnitude than the H(+)-ATPase on the same membrane

Belongs to the H(+)-translocating pyrophosphatase (TC 3,A,10) family, K(+)-stimulated subfamily


This is Recombination protein 107 protein, from Baker's yeast, contains 314 amino acids, locates in Nucleus.

Essential for meiotic chromosome segregation, MER1 and MER2 proteins must interact directly or indirectly, MER1 might be responsible for regulating the MER2 gene and/or gene product, MER2 is not required for mitosis and mitotic DNA repair mechanisms, Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation


This is Ribonucleoside-diphosphate reductase large chain 2 protein, from Baker's yeast, contains 869 amino acids, is soluble, locates in Cytoplasm.


This is Ephrin type-A receptor 1 protein, from Human, contains 976 amino acids, is membrane-bound, locates in Cell membrane.

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand, Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC, Also plays a role in angiogenesis and regulates cell proliferation, May play a role in apoptosis

Belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily


This is Guanine nucleotide exchange factor SRM1 protein, from Baker's yeast, contains 482 amino acids, locates in Nucleus.

Guanine nucleotide exchange factor that promotes the exchange of GSP1/GSP2-bound GDP by GTP and controls RNA metabolism and transport, Involved in yeast pheromone response pathway and in mRNA metabolism, Involved in nuclear pore complex (NPC) assembly and required for mRNA and ribosome nuclear export, Binds chromatin and is involved NPC-mediated transcriptional control


This is D(4) dopamine receptor protein, from Human, contains 419 amino acids, is membrane-bound, locates in Cell membrane.

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior, Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383), Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383), Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity)


This is 9,11-endoperoxide prostaglandin H2 reductase protein, from Leishmania major, contains 284 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2, Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde

Belongs to the aldo/keto reductase family


This is Lactoperoxidase protein, from Human, contains 712 amino acids, is soluble, locates in Extracellular.

Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity), Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity), Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:12626341), Shows antibacterial properties against Pseudomonas aeruginosa (PubMed:12626341), The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro (PubMed:12626341), Present in mammary and salivary gland secretions and may contribute to airway host defense against infection (PubMed:12626341), May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity)

Belongs to the peroxidase family, XPO subfamily


This is rRNA 2'-O-methyltransferase fibrillarin protein, from Human, contains 321 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930, PubMed:32017898), Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930), Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity), Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity), Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes (PubMed:32017898), U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898), Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Belongs to the methyltransferase superfamily, Fibrillarin family


This is T-cell acute lymphocytic leukemia protein 1 homolog protein, from Mouse, contains 329 amino acids, locates in Nucleus.

Implicated in the genesis of hemopoietic malignancies, It may play an important role in hemopoietic differentiation, Serves as a positive regulator of erythroid differentiation


This is DNA-3-methyladenine glycosylase protein, from Baker's yeast, contains 296 amino acids, locates in Nucleus.

Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions

Belongs to the alkylbase DNA glycosidase AlkA family


This is V-type proton ATPase subunit E protein, from Baker's yeast, contains 233 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8416931), V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:8416931, PubMed:2145285)

Belongs to the V-ATPase E subunit family


This is Nitrogen permease reactivator protein protein, from Baker's yeast, contains 790 amino acids, is soluble, locates in Cytoplasm.

Nutrient-regulated protein kinase that promotes the activity of at least 6 distinct transport systems for nitrogenous nutrients under conditions of nitrogen catabolite derepression, Under poor nitrogen growth conditions, required for post-Golgi sorting of the general amino acid permease GAP1 and the three known ammonia permeases, MEP1/2/3, to the plasma membrane, Contributes also to the stability and the retention of GAP1 at the plasma membrane, Inversely, promotes the degradation of tryptophan permease TAT2 under the same conditions, Activity is regulated by the TOR signaling pathway via phosphatase SIT4, Although thought to be involved in regulation of GLN3-dependent transcription by nitrogen catabolite repression, this seems to be an indirect effect from the reduced uptake of the nitrogen-repressing compound

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Serine/threonine-protein kinase RAD53 protein, from Baker's yeast, contains 821 amino acids, locates in Nucleus.

Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints, Phosphorylates proteins on serine, threonine, and tyrosine, Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5, Seems to be involved in the phosphorylation of RPH1

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CHEK2 subfamily


This is Zinc finger protein 42 protein, from Mouse, contains 288 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency, Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST, Binds DXPas34 enhancer within the TSIX promoter, Involved in ES cell self-renewal

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Myeloid differentiation primary response protein MyD88 protein, from Mouse, contains 296 amino acids, is soluble, locates in Cytoplasm.

Defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS)


This is Potassium voltage-gated channel subfamily A member 5 protein, from Human, contains 613 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient, The channel alternates between opened and closed conformations in response to the voltage difference across the membrane, Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714), Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714), Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714), May play a role in regulating the secretion of insulin in normal pancreatic islets, Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461)

Belongs to the potassium channel family, A (Shaker) (TC 1,A,1,2) subfamily, Kv1,5/KCNA5 sub-subfamily


This is Galanin peptides protein, from Human, contains 123 amino acids, is soluble, locates in Extracellular.

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3, This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion


This is ATP-dependent DNA helicase CHL1 protein, from Baker's yeast, contains 861 amino acids, locates in Nucleus.

ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (PubMed:10931920), May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (PubMed:15020404, PubMed:14742714), Has a specific role in chromosome segregation during meiosis II (PubMed:15226378)

Belongs to the DEAD box helicase family, DEAH subfamily, DDX11/CHL1 sub-subfamily


This is Dual specificity protein kinase CLK1 protein, from Mouse, contains 483 amino acids, locates in Nucleus.

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates, Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing, Phosphorylates: SRSF1, SRSF3 and PTPN1, Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, Lammer subfamily


This is Alpha-1-antitrypsin 1-2 protein, from Mouse, contains 413 amino acids, is soluble, locates in Extracellular.

Inhibitor of serine proteases, Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin


This is Cyclin-O protein, from Human, contains 350 amino acids, is soluble, locates in Cytoplasm.

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation, Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking


This is Gamma-aminobutyric acid receptor subunit gamma-2 protein, from Mouse, contains 474 amino acids, is membrane-bound, locates in Cell membrane.

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275), Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275), The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275), The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275), Functions also as histamine receptor and mediates cellular responses to histamine (PubMed:18281286)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Gamma-aminobutyric acid receptor (TC 1,A,9,5) subfamily, GABRG2 sub-subfamily


This is Solute carrier family 2, facilitated glucose transporter member 5 protein, from Human, contains 501 amino acids, is membrane-bound, locates in Cell membrane.

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649, PubMed:17710649, PubMed:29548810), Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905), Essential for fructose uptake in the small intestine (By similarity), Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity), Required for the development of high blood pressure in response to high dietary fructose intake (By similarity)

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily