This is Purine-uracil permease NCS1 protein, from Mouse-ear cress, contains 599 amino acids, is membrane-bound, locates in Plastid.

Nucleobase-proton symporter that facilitates the uptake of nucleobases in the cells, Can transport adenine, guanine and uracil (PubMed:22616996, PubMed:22474184, PubMed:24621654), Contributes to uracil import into plastids for plastidic uracil salvage which is essential for plant growth and development (PubMed:22474184)

Belongs to the purine-cytosine permease (2,A,39) family


This is Non-specific lipid transfer protein GPI-anchored 2 protein, from Mouse-ear cress, contains 193 amino acids, is membrane-bound, locates in Cell membrane.

Lipid transfer protein that, together with LTPG1, binds to lipids and functions as a component of the cuticular lipid export machinery that performs extensive export of intracellular lipids (e,g, C29 alkane) from epidermal cells to the surface to build the cuticular wax layer and silique walls (PubMed:22891199), Contributes to pre-invasive defense against some non-host powdery mildew pathogens by preventing the penetration of the epidermal cell wall by the fungal agents (e,g, Blumeria graminis f, sp, hordei (Bgh)) (PubMed:30102837), Involved in seed and ovule maturation and development, probably by regulating the fatty acids homeostasis during suberin and sporopollenin biosynthesis or deposition (PubMed:24460633)


This is UDP-glucuronic acid decarboxylase 2 protein, from Mouse-ear cress, contains 445 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose, Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis

Belongs to the NAD(P)-dependent epimerase/dehydratase family, UDP-glucuronic acid decarboxylase subfamily


This is Xyloglucan 6-xylosyltransferase 1 protein, from Mouse-ear cress, contains 460 amino acids, is membrane-bound, locates in Golgi apparatus.

Xylosyltransferase specific to UDP-D-xylose that accepts both cellopentaose and cellohexaose as substrates, with a better use of cellohexaose, to produce xyloglucan, Adds preferentially the first xylosyl residue to the fourth glucosyl residue from the reducing end of both acceptors, Transfer one xylose mainly to the second glucose residue from the non-reducing end, The acceptor should have a minimum of four glucose residues

Belongs to the glycosyltransferase 34 family


This is bZIP transcription factor 53 protein, from Mouse-ear cress, contains 146 amino acids, locates in Nucleus.

Transcription activator that binds DNA to the C-box-like motif (5'-TGCTGACGTCA-3'), ABRE elements, G-box-like motif (5'-CCACGTGGCC-3'), DOF (5'-AAAG-3'), I-box (5'-GATAA-3'), BS1 (5'-AGCGGG-3'), MY3 (5'-CGACG-3'), 5'-CAGTGCGC-3' and 5'-ACTCAT-3' sequence in target gene promoters (PubMed:15047879, PubMed:16810321, PubMed:19531597, PubMed:21278122, PubMed:25108460), DNA-binding and subsequent transcription activation is triggered by heterodimerization with other bZIP proteins (e,g, BZIP1, BZIP10 and BZIP25) (PubMed:16810321, PubMed:19531597, PubMed:21278122), Promotes POX1/PRODH1 expression in response to hypoosmolarity stress (PubMed:15047879, PubMed:16810321), Transcriptional activator of seed maturation (MAT) genes (e,g, AT2S2), including seed storage protein (SSP) and late embryogenesis abundant (LEA) genes (PubMed:19531597), Activated by low energy stress both by transcriptional and post-transcriptional mechanisms, Promotes dark-induced senescence and participates in the transcriptional reprogramming of amino acid metabolism during the dark-induced starvation response, especially when heterodimerized with BZIP1, by triggering accumulation of specific proteins including ASN1 and POX1/PRODH1 (PubMed:21278122)


This is Calvin cycle protein CP12-2, chloroplastic protein, from Mouse-ear cress, contains 131 amino acids, locates in Plastid.

Acts as a linker essential in the assembly of a core complex of PRK/GAPDH, Coordinates the reversible inactivation of chloroplast enzymes GAPDH and PRK during darkness in photosynthetic tissues


This is Histone deacetylase HDT3 protein, from Mouse-ear cress, contains 294 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Involved in the modulation of abscisic acid and stress-responsive genes

Belongs to the histone deacetylase HD2 family


This is Transcription repressor OFP1 protein, from Mouse-ear cress, contains 270 amino acids, locates in Nucleus.

Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors, Controls the subcellular localization of the homeodomain protein BLH1, Plays a role in the regulation of cell elongation by controlling the expression of GA20OX1, a gene that encodes a key enzyme in gibberellin biosynthesis, May play a role in double-stranded DNA repair through the DNA non-homologous end joining (NHEJ) pathway along with KU70 and KU80 protein complex, Possesses DNA-binding activity towards double-stranded and single-stranded DNA in vitro


This is Phosphatidate cytidylyltransferase 5, chloroplastic protein, from Mouse-ear cress, contains 399 amino acids, is membrane-bound, locates in Plastid.

May be involved in the synthesis of minor phospholipids and in modulation of IP3-mediated signal transduction, Promotes the biosynthesis of plastidial phosphatidylglycerol (PG) which is required for structure and function of thylakoid membranes and, hence, for photoautotrophic growth


This is Thylakoid ADP,ATP carrier protein, chloroplastic protein, from Mouse-ear cress, contains 415 amino acids, is membrane-bound, locates in Plastid.

Specifically transports adenine nucleotides, Involved in the uptake of ATP into thylakoids in exchange for lumenal ADP

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Serine carboxypeptidase 24 protein, from Mouse-ear cress, contains 465 amino acids, is soluble, locates in Extracellular.

Active serine carboxypeptidase with broad substrate preference, including basic and hydrophilic groups, Processes a protein involved in an early event in the brassinosteroid signaling pathway


This is Gamma-glutamyl peptidase 1 protein, from Mouse-ear cress, contains 250 amino acids, is soluble, locates in Cytoplasm.

Involved in glucosinolate biosynthesis, Hydrolyzes the gamma-glutamyl peptide bond of several glutathione (GSH) conjugates to produce Cys-Gly conjugates related to glucosinolates, The gamma-Glu-Cys-Gly-GSH conjugates are the sulfur-donating molecule in glucosinolate biosynthesis (PubMed:19483696, PubMed:21712415), Converts phenylacetohydroximoyl-GSH to benzylglucosinolate (PubMed:19483696), Can use the GSH conjugate of the camalexin intermediate IAN (GS-IAN) as substrate, Required for the biosynthesis of camalexin, a pathogen-inducible phytoalexin with antibacterial and antifungal properties (PubMed:21712415)


This is ABC transporter B family member 24, mitochondrial protein, from Mouse-ear cress, contains 680 amino acids, is membrane-bound, locates in Mitochondrion.

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity), Not involved in the export of cyclic pyranopterin monophosphate (cPMP) from mitochondria to the cytosol

Belongs to the ABC transporter superfamily, ABCB family, Heavy Metal importer (TC 3,A,1,210) subfamily


This is Transcription factor LAF1 protein, from Mouse-ear cress, contains 283 amino acids, locates in Nucleus.

Transcription factor that promotes photomorphogenesis in the light by participating in the transmission of phytochrome A (phyA) signals to downstream responses (PubMed:11581165, PubMed:19482971), Probably acts by activating expression of light-induced genes, In darkness, its degradation prevents the activation of light-induced genes (PubMed:11581165)


This is 4-coumarate--CoA ligase-like 7 protein, from Mouse-ear cress, contains 544 amino acids, locates in Peroxisome.

Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors (PubMed:15677481, PubMed:18267944), Acts as a carboxylate--CoA ligase that can use various carboxylates as substrates (PubMed:15677481, PubMed:18267944), Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Peptide methionine sulfoxide reductase B3 protein, from Mouse-ear cress, contains 176 amino acids, locates in Endoplasmic reticulum.

Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins, Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation, Involved in cold tolerance, Eliminates MetSO and reactive oxygen species that accumulate at the ER during cold acclimation, MSRB family specifically reduces the MetSO R-enantiomer (By similarity)

Belongs to the MsrB Met sulfoxide reductase family


This is NAC domain-containing protein 69 protein, from Mouse-ear cress, contains 457 amino acids, is membrane-bound, locates in Nucleus.

Transcription activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP), Involved in salt stress response during seed germination and seedling growth, Binds the auxin-responsive IAA30 gene promoter and may serve as a molecular link that interconnects a developmental feedback loop of auxin signaling with a salt signal transduction pathway during seed germination (PubMed:21450938)


This is Rhodanese-like domain-containing protein 4, chloroplastic protein, from Mouse-ear cress, contains 466 amino acids, is membrane-bound, locates in Plastid.

Rhodanese domain-containing protein required for anchoring ferredoxin--NADP reductase to the thylakoid membranes and sustaining efficient linear electron flow (LEF)


This is Protein NRT1/ PTR FAMILY 2.7 protein, from Mouse-ear cress, contains 558 amino acids, is membrane-bound, locates in Cell membrane.

Transporter involved in a passive nitrate efflux, Not competent for chloride transport

Belongs to the major facilitator superfamily, Proton-dependent oligopeptide transporter (POT/PTR) (TC 2,A,17) family


This is Pentatricopeptide repeat-containing protein At3g63370, chloroplastic protein, from Mouse-ear cress, contains 960 amino acids, locates in Plastid.

Involved in RNA editing event in chloroplasts, Required for the editing of a single site in rps14 transcript

Belongs to the PPR family, PCMP-H subfamily


This is Homeobox-leucine zipper protein ATHB-12 protein, from Mouse-ear cress, contains 235 amino acids, locates in Nucleus.

Probable transcription activator that may act as growth regulators in response to water deficit

Belongs to the HD-ZIP homeobox family, Class I subfamily


This is Zinc finger BED domain-containing protein DAYSLEEPER protein, from Mouse-ear cress, contains 696 amino acids, has 1 BED-type Zinc finger, locates in Nucleus.

BED-type

Transposase-like protein that is essential for plant growth and development, Binds the promoter region of the DNA helicase KU70 and genes involved in chromatin remodeling, May regulate global gene expression by recruiting other cellular factors


This is Very-long-chain enoyl-CoA reductase protein, from Mouse-ear cress, contains 310 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle, This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle, This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation, Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators, Required for the elongation of fatty acids precursors of sphingolipids, storage lipids and cuticular waxes

Belongs to the steroid 5-alpha reductase family


This is Telomere repeat-binding factor 3 protein, from Mouse-ear cress, contains 295 amino acids, locates in Nucleus.

Binds preferentially double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand

Belongs to the histone H1/H5 family, SMH subfamily


This is Probable pectin methylesterase CGR2 protein, from Mouse-ear cress, contains 261 amino acids, is membrane-bound, locates in Golgi apparatus.

Together with CGR3, required for homogalacturonan pectins (HG) methylesterification in the Golgi apparatus prior to integration into cell walls, essential for general growth and development (PubMed:25704846, PubMed:27208234), Promotes rosette growth (PubMed:25704846), Impacts carbon (C) partitioning, photosynthesis and respiration efficiency by influencing leaf mesophyll cell walls morphology and physiology; pectin methylesterification modulates both expansion and positioning of cells in leaves, probably by changing cell walls plasticity (PubMed:27208234)

Belongs to the class I-like SAM-binding methyltransferase superfamily


This is Gamma-tubulin complex component 4 protein, from Mouse-ear cress, contains 745 amino acids, is soluble, locates in Cytoplasm.

Gamma-tubulin complex is essential for the control of microtubular network remodeling in the course of initiation and development of giant-feeding cells, and for the successful reproduction of nematodes (e,g, Meloidogyne spp,) in their plant hosts (By similarity)


This is Protein NRT1/ PTR FAMILY 8.1 protein, from Mouse-ear cress, contains 570 amino acids, is membrane-bound, locates in Cell membrane.

Peptide transporter, Mediates the transport of di- and tripeptides, High affinity transporter with low selectivity, No transport of amino acids


This is Fructokinase-like 1, chloroplastic protein, from Mouse-ear cress, contains 471 amino acids, locates in Plastid.

Required for proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription, Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression

Belongs to the carbohydrate kinase PfkB family


This is Branched-chain-amino-acid aminotransferase 3, chloroplastic protein, from Mouse-ear cress, contains 413 amino acids, locates in Plastid.

Converts 2-oxo acids to branched-chain amino acids, Acts on leucine, isoleucine and valine, Also involved in methionine chain elongation cycle of aliphatic glucosinolate formation, Catalyzes the conversion of 5-methylthiopentyl-2-oxo and 6-methylthiohexyl-2-oxo acids to their respective Met derivatives, homomethionine and dihomo-methionine, respectively

Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family


This is Meiotic recombination protein SPO11-1 protein, from Mouse-ear cress, contains 362 amino acids, locates in Nucleus.

Component of a topoisomerase 6 complex specifically required for meiotic recombination (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:26917763), Together with MTOPVIB, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (PubMed:26917763, PubMed:19763177), The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles (PubMed:11157765, PubMed:17018031, PubMed:17965269, PubMed:26917763)


This is DNA (cytosine-5)-methyltransferase DRM2 protein, from Mouse-ear cress, contains 626 amino acids, is soluble, locates in Nucleus.

Involved in de novo DNA methylation, Controls asymmetric and CpNpG methylation, Required for FWA gene silencing but not for the maintenance of SUP gene silencing, Functionally redundant to CMT3 to maintain non-CpG methylation, Involved in RNA-directed DNA methylation (RdDM) (PubMed:12121623, PubMed:12151602, PubMed:14680640), Acts as major DNA methyltransferase in the RdDM pathway, and is essential for RNA-directed de novo DNA methylation of cytosines in all sequence contexts (PubMed:21060858, PubMed:21212233), Associates with long non-coding RNA (lncRNA) produced by RNA polymerase V (Pol V), This association is dependent on AGO4 and IDN2, and results in DNA methylation of RdDM target loci (PubMed:24862207)

Belongs to the class I-like SAM-binding methyltransferase superfamily, DRM-methyltransferase family


This is Dihydrolipoyl dehydrogenase 2, mitochondrial protein, from Mouse-ear cress, contains 507 amino acids, is soluble, locates in Mitochondrion.

Lipoamide dehydrogenase is a component of the glycine decarboxylase (GDC) or glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes, LPD1 is probably the protein most often associated with the glycine decarboxylase complex while LPD2 is probably incorporated into alpha-ketoacid dehydrogenase complexes

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family


This is Dihydrolipoyl dehydrogenase 1, mitochondrial protein, from Mouse-ear cress, contains 507 amino acids, is soluble, locates in Mitochondrion.


This is ABSCISIC ACID-INSENSITIVE 5-like protein 5 protein, from Mouse-ear cress, contains 416 amino acids, locates in Nucleus.

Involved in ABA and stress responses and acts as a positive component of glucose signal transduction, Functions as transcriptional activator in the ABA-inducible expression of rd29B, Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter

Belongs to the bZIP family, ABI5 subfamily


This is Peroxiredoxin-2F, mitochondrial protein, from Mouse-ear cress, contains 201 amino acids, is soluble, locates in Mitochondrion.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides, Reduces preferentially hydrogen peroxide rather than alkyl peroxides, May be involved in mitochondrial redox homeostasis

Belongs to the peroxiredoxin family, Prx5 subfamily


This is Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial protein, from Mouse-ear cress, contains 483 amino acids, is soluble, locates in Mitochondrion.

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2), It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3), Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component (By similarity), Required during sugar starvation and acts under the control of a sugar-sensing mechanism involving Ser/Thr kinases and phosphatases

Belongs to the 2-oxoacid dehydrogenase family


This is Rop guanine nucleotide exchange factor 11 protein, from Mouse-ear cress, contains 543 amino acids, is soluble, locates in Cytoplasm.

Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP, Functions as a light-signaling switch that functions in root growth and development through the activation of Rop in a phytochrome-dependent manner, May act as a negative regulator of phytochrome-mediated primary root development


This is Transcription factor MUTE protein, from Mouse-ear cress, contains 202 amino acids, locates in Nucleus.

Transcription factor, Together with FMA and SPCH, regulates the stomata formation, Required for the differentiation of stomatal guard cells, by promoting successive asymmetric cell divisions and the formation of guard mother cells, Promotes the conversion of the leaf epidermis into stomata


This is Guanine nucleotide-binding protein-like NSN1 protein, from Mouse-ear cress, contains 582 amino acids, locates in Nucleus.

Involved in the differentiation of epidermal cells, probably via the regulation of the expression of meristem-related genes (e,g, CLV3, STM, KNAT1, CUC2 and AG) and of leaf polarity-related genes (e,g, YAB5, FIL, AS2, PHB and PHV) (PubMed:22058024, PubMed:22357616), May play a role in regulating cellular proliferation (By similarity), Necessary for flower development, probably by preventing apical dominance through the down-regulation of AG expression (PubMed:22357616), Required for embryogenesis, leaf and cotyledon development, as well as for leaf polarity establishment (PubMed:22058024), Plays an important role in plant growth and senescence by modulating ribosome biogenesis in nucleolus, Possesses GTPAse activity in vitro, Possesses RNA binding activity in vitro, Associates with ribosomes (PubMed:26163696)

Belongs to the TRAFAC class YlqF/YawG GTPase family


This is 9-cis-epoxycarotenoid dioxygenase NCED9, chloroplastic protein, from Mouse-ear cress, contains 657 amino acids, is soluble, locates in Plastid.

Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity, Catalyzes the first step of abscisic-acid biosynthesis from carotenoids, Contributes probably to abscisic acid synthesis for the induction of seed dormancy

Belongs to the carotenoid oxygenase family


This is Transcription factor bHLH150 protein, from Mouse-ear cress, contains 211 amino acids, locates in Nucleus.

Atypical bHLH transcription factor probably unable to bind DNA, Negatively regulates brassinosteroid signaling


This is E3 ubiquitin protein ligase DRIP1 protein, from Mouse-ear cress, contains 421 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that acts as a negative regulator of the response to water stress, Mediates ubiquitination and subsequent proteasomal degradation of the drought-induced transcriptional activator DREB2A, Functionally redundant with DRIP2


This is Protein ACTIVITY OF BC1 COMPLEX KINASE 3, chloroplastic protein, from Mouse-ear cress, contains 711 amino acids, is soluble, locates in Plastid.

Kinase that can phosphorylate the tocopherol cyclase VTE1, a key enzyme of tocopherol (vitamin E) metabolism and involved in the recycling of oxidated alpha-tocopherol quinone, possibly stabilizing it at plastoglobules, Regulates also membrane prenylquinone composition (PubMed:23632854), Required for photooxidative stress responses to prevent photosystem II core and chlorophyll degradations, Together with ABC1K1, contributes to plastoglobule (PG) function in prenyl-lipid metabolism, stress response, and thylakoid remodeling (PubMed:23673981, PubMed:23632854), Promotes photodamage of chloroplasts under continuous red light, thus working in opposition to ABC1K1 (PubMed:25882344)

Belongs to the protein kinase superfamily, ADCK protein kinase family


This is Protein SOMBRERO protein, from Mouse-ear cress, contains 371 amino acids, locates in Nucleus.

Transcription regulator, Together with BRN1 and BRN2, regulates cellular maturation of root cap, Represses stem cell-like divisions in the root cap daughter cells, and thus promotes daughter cell fate, Inhibits expression of its positive regulator FEZ in a feedback loop for controlled switches in cell division plane, Promotes the expression of genes involved in secondary cell walls (SCW) biosynthesis


This is Galactolipase DONGLE, chloroplastic protein, from Mouse-ear cress, contains 471 amino acids, locates in Plastid.

Sn-1-specific phospholipase that releases free fatty acids from phosphatidylcholine, Has a higher galactolipase activity than phospholipase A1 activity when digalactosyldiacylglycerol (DGDG) is used as substrate, Catalyzes the initial step of jasmonic acid biosynthesis, Required for the biosynthesis of basal-level endogenous jasmonate in vegetative tissues, Regulates leaves growth, Not essential for jasmonate biosynthesis after wounding or upon pathogen infection

Belongs to the AB hydrolase superfamily, Lipase family


This is Acyl-CoA-binding domain-containing protein 4 protein, from Mouse-ear cress, contains 668 amino acids, is soluble, locates in Cytoplasm.

Binds medium- and long-chain acyl-CoA esters with very high affinity, Can interact in vitro with oleoyl-CoA, barely with palmitoyl-CoA, but not with arachidonyl-CoA, May function as an intracellular carrier of acyl-CoA esters, Plays a role in the biosynthesis of membrane lipids including galactolipids and phospholipids


This is Receptor-like protein 30 protein, from Mouse-ear cress, contains 786 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for microbe-associated molecular patterns (MAMPs) that induces a BAK1-dependent basal immune response to necrotrophic fungi (e,g, S,sclerotiorum) in the presence of MAMPs (e,g, flg22 and SCLEROTINIA CULTURE FILTRATE ELICITOR1 (SCFE1) from the necrotrophic fungal pathogen S, sclerotiorum), Functionality seems to depend on the presence of the receptor kinase SOBIR1 as an adapter protein (PubMed:24104566), Required for full non-host resistance to bacterial pathogens (e,g, P,syringae pv phaseolicola) (PubMed:18434605)


This is Peroxisomal adenine nucleotide carrier 1 protein, from Mouse-ear cress, contains 322 amino acids, is membrane-bound, locates in Peroxisome.

Peroxisomal adenine nucleotide transporter catalyzing the counterexchange of ATP with AMP, ATP is needed by reactions that generate acyl-CoA for peroxisomal fatty acid beta-oxidation during postgerminative growth, Required for the beta-oxidation reactions involved in auxin biosynthesis and for the conversion of seed-reserved triacylglycerols into sucrose that is necessary for growth before the onset of photosynthesis

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Pyruvate, phosphate dikinase regulatory protein 2 protein, from Mouse-ear cress, contains 377 amino acids, is soluble, locates in Cytoplasm.

Bifunctional serine/threonine kinase and phosphorylase involved in the dark/light-mediated regulation of PPDK by catalyzing its phosphorylation/dephosphorylation, Has a much lower phosphotransferase activity than PDRP1 (PubMed:21883547), Can use ADP as a high specificity substrate and GDP as a lower affinity substrate, but has no activity with UDP (PubMed:21414960)

Belongs to the pyruvate, phosphate/water dikinase regulatory protein family, PDRP subfamily


This is 3-ketoacyl-CoA synthase 1 protein, from Mouse-ear cress, contains 528 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Contributes to cuticular wax and suberin biosynthesis, Involved in both decarbonylation and acyl-reduction wax synthesis pathways, Elongase condensing enzyme mostly active with saturated fatty acids, especially with 16:0, 16:1, 18:0, and 20:0, Mediates the synthesis of VLCFAs from 20 to 26 carbons in length (e,g, C20:1, C20, C22, C24 and C26)

Belongs to the thiolase-like superfamily, Chalcone/stilbene synthases family


This is Subtilisin-like protease SBT3.3 protein, from Mouse-ear cress, contains 777 amino acids, is soluble, locates in Extracellular.

Serine protease that plays a role in the control of the establishment of immune priming and systemic induced resistance


This is Beta-1,6-galactosyltransferase GALT31A protein, from Mouse-ear cress, contains 399 amino acids, is membrane-bound, locates in Golgi apparatus.

Beta-galactosyltransferase involved in elongation of beta-1,6-linked galactan side chains on arabinogalactan proteins, Required for the progression of embryogenesis beyond the globular stage (PubMed:23837821), Beta-galactosyltransferase involved in the biosynthesis of type II arabinogalactan, Transfers galactose from UDP-galactose to a mixture of various oligosaccharides derived from arabinogalactan proteins, Forms a complex with GALT29A that can work cooperatively to enhance the activities of adding galactose residues at O6 positions to beta-1,6-linked galactan and beta-1,3-linked galactan (PubMed:24693939)

Belongs to the glycosyltransferase 31 family


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 protein, from Rabbit, contains 822 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions, Contributes to the native pacemaker currents in heart (If) and in neurons (Ih), May mediate responses to sour stimuli

Belongs to the potassium channel HCN family


This is Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial protein, from Pig, contains 455 amino acids, locates in Mitochondrion.

Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (PubMed:10806400), The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:10806400), The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity), A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity)


This is Glutathione S-transferase omega-1 protein, from Pig, contains 241 amino acids, is soluble, locates in Cytoplasm.

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities, Has S-(phenacyl)glutathione reductase activity, Has also glutathione S-transferase activity, Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid

Belongs to the GST superfamily, Omega family


This is Thioredoxin reductase 2, mitochondrial protein, from Bovine, contains 511 amino acids, locates in Mitochondrion.

Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity), Maintains thioredoxin in a reduced state, May play a role in redox-regulated cell signaling


This is Aquaporin-1 protein, from Dog, contains 271 amino acids, is membrane-bound, locates in Cell membrane.

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient, Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane

Belongs to the MIP/aquaporin (TC 1,A,8) family


This is Poly(ADP-ribose) glycohydrolase 2 protein, from Caenorhabditis elegans, contains 485 amino acids, is soluble, locates in Cytoplasm.

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:17188026), Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells (By similarity)

Belongs to the poly(ADP-ribose) glycohydrolase family


This is Fem-3 mRNA-binding factor 1 protein, from Caenorhabditis elegans, contains 614 amino acids, is soluble, locates in Cytoplasm.

Involved in the control of stem cells and sex determination in the C,elegans hermaphrodite germline (PubMed:9393998), May also play a role in the hermaphrodite germline proliferation and oogenesis (PubMed:9393998, PubMed:15454534), Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch (PubMed:9393998, PubMed:15454534), Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b (PubMed:9393998, PubMed:15454534), In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone (PubMed:21455289), By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone (PubMed:16319922), Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes (PubMed:22820175)


This is Chloroquine resistance transporter protein, from Plasmodium falciparum, contains 424 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Belongs to the CRT-like transporter family


This is Zinc finger protein sens protein, from Fruit fly, contains 541 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS), Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation, Correct expression requires expression of scalloped (sd), Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination


This is MIP-related peptides protein, from California sea hare, contains 735 amino acids, is soluble, locates in Extracellular.

Has some structural and functional features similar to vertebrate opioid peptides, AMRPs are inhibitory on Aplysia esophagus, penis retractor muscle, and body wall muscle


This is Fragile X messenger ribonucleoprotein 1 homolog protein, from Fruit fly, contains 684 amino acids, is soluble, locates in Cytoplasm.

Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs (PubMed:11046149, PubMed:11733059, PubMed:12368261, PubMed:17178403), Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:35165263), Mainly acts as an activator of mRNA translation: promotes translation of stored mRNAs in oocytes (PubMed:30115809), Can also act as a negative translational regulator of specific mRNAs (PubMed:11733059, PubMed:17178403), Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function (PubMed:11733059), Localizes to specific N6-methyladenosine (m6A)-containing RNAs as part of a complex with the m6A reader Ythdf and thereby regulates axonal growth in the mushroom bodies and neuromuscular junctions (PubMed:33428246), Specifically recognizes and binds a subset of N6-methyladenosine (m6A)-containing mRNAs in embryos, promoting formation of a phase-separated membraneless compartment that mediates degradation of maternal mRNAs (PubMed:35165263), May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC) (PubMed:12368261, PubMed:14508492), Required for stability of the central pair of microtubules in the spermatid axoneme (PubMed:15183715), Regulates photoreceptor structure and neuromuscular junction (NMJ) neurotransmission in the eye (PubMed:11733059, PubMed:17178403), During embryogenesis, involved in germline fate determination (PubMed:16949822)


This is Cytochrome P450 302a1, mitochondrial protein, from Fruit fly, contains 489 amino acids, is membrane-bound, locates in Mitochondrion.

Required for CNS development; negatively regulates glial cell division in the embryonic midline, Involved in the metabolism of insect hormones; responsible for ecdysteroid C22-hydroxylase activity, May be involved in the breakdown of synthetic insecticides


This is Probable N-acetyltransferase san protein, from Fruit fly, contains 184 amino acids, is soluble, locates in Cytoplasm.

(Microbial infection) Required for optimal replication of E,chaffeensis in the immune tissues, hemocytes, and fat body


This is Potassium channel toxin alpha-KTx 3.6 protein, from Manchurian scorpion, contains 60 amino acids, is soluble, locates in Extracellular.

Blocks voltage-gated potassium channels, At 2 uM, blocks rat Kv1,1/KCNA1 and Kv1,3/KCNA3, has a strong effect on rat Kv1,2/KCNA2 and Kv1,6/KCNA6 as well as a moderate effect on Shaker IR

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily


This is Cardio acceleratory peptide 2b protein, from Fruit fly, contains 151 amino acids, is soluble, locates in Extracellular.

CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa receptor (PubMed:12177421, PubMed:12459185), CAP-1 and CAP-2 are probably components of the signal transduction pathway that leads to Malpighian tubule fluid secretion via the second messenger nitric oxide (PubMed:11959669), CAP-3 is a ligand for the PK1-R G-protein coupled receptor (PubMed:16054112)


This is Rhesus-like glycoprotein A protein, from Social amoeba, contains 527 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May be a carbon dioxide/bicarbonate transporter

Belongs to the ammonium transporter (TC 2,A,49) family, Rh subfamily


This is Dynein axonemal assembly factor 11 protein, from Trypanosoma brucei brucei, contains 383 amino acids, is soluble, locates in Cytoplasm.

Involved in the regulation of the cell cycle; is required for the basal body replication and new flagellum biogenesis


This is Myeloid leukemia factor protein, from Fruit fly, contains 376 amino acids, is soluble, locates in Cytoplasm.


This is Thioredoxin reductase 2, mitochondrial protein, from Human, contains 524 amino acids, locates in Mitochondrion.

Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690), Maintains thioredoxin in a reduced state, May play a role in redox-regulated cell signaling

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family


This is Zinc finger CCHC domain-containing protein 17 protein, from Human, contains 241 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type


This is ABC-type oligopeptide transporter ABCB9 protein, from Human, contains 766 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30877195, PubMed:31417173, PubMed:30353140), Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430), Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173), Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309)

Belongs to the ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3,A,1,209) subfamily


This is Calcium-binding protein 5 protein, from Human, contains 173 amino acids, is soluble, locates in Cytoplasm.

Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity), Involved in the transmission of light signals (By similarity), May positively regulate neurotransmitter vesicle endocytosis and exocytosis in a salt-dependent manner (By similarity), May play a role in the extension and network organization of neurites (By similarity)


This is Transcription and mRNA export factor ENY2 protein, from Human, contains 101 amino acids, is soluble, locates in Nucleus.

Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes, The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination, Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B, The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription, Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879), As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820)


This is 5'(3')-deoxyribonucleotidase, mitochondrial protein, from Human, contains 228 amino acids, locates in Mitochondrion.

Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP, Has only marginal activity towards dIMP and dGMP

Belongs to the 5'(3')-deoxyribonucleotidase family


This is Myoneurin protein, from Human, contains 610 amino acids, has 8 C2H2-type Zinc finger, locates in Nucleus.

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Ubiquitin-conjugating enzyme E2 T protein, from Human, contains 197 amino acids, locates in Nucleus.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, Catalyzes monoubiquitination, Involved in mitomycin-C (MMC)-induced DNA repair, Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106), Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784), May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602), In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386)

Belongs to the ubiquitin-conjugating enzyme family


This is H/ACA ribonucleoprotein complex subunit 3 protein, from Human, contains 64 amino acids, locates in Nucleus.

Required for ribosome biogenesis and telomere maintenance, Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA, This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1, Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs, May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme


This is Lysophosphatidic acid phosphatase type 6 protein, from Human, contains 428 amino acids, locates in Mitochondrion.

Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol, Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid

Belongs to the histidine acid phosphatase family


This is Interleukin-26 protein, from Human, contains 171 amino acids, is soluble, locates in Extracellular.

May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function, May play a role in inflammatory bowel disease, Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT, Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1, Decreases proliferation of intestinal epithelial cells, Is inhibited by heparin


This is Inward rectifier potassium channel 16 protein, from Human, contains 418 amino acids, is membrane-bound, locates in Cell membrane.

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it, Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages, The inward rectification is mainly due to the blockage of outward current by internal magnesium, KCNJ16 may be involved in the regulation of fluid and pH balance, In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201)

Belongs to the inward rectifier-type potassium channel (TC 1,A,2,1) family, KCNJ16 subfamily


This is Complex I assembly factor TIMMDC1, mitochondrial protein, from Human, contains 285 amino acids, is membrane-bound, locates in Mitochondrion.

Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I), Participates in constructing the membrane arm of complex I


This is A-kinase-interacting protein 1 protein, from Human, contains 210 amino acids, locates in Nucleus.

Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA, Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade


This is Solute carrier family 52, riboflavin transporter, member 3 protein, from Human, contains 469 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:20463145, PubMed:22273710, PubMed:24264046, PubMed:27702554), Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145)

Belongs to the riboflavin transporter family


This is Leucine zipper transcription factor-like protein 1 protein, from Human, contains 299 amino acids, is soluble, locates in Cytoplasm.

Regulates ciliary localization of the BBSome complex, Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation, May play a role in neurite outgrowth, May have tumor suppressor function


This is Suppressor of SWI4 1 homolog protein, from Human, contains 473 amino acids, locates in Nucleus.


This is APOBEC1 complementation factor protein, from Human, contains 594 amino acids, locates in Cytoplasm.

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA, Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine, The complex also protects the edited APOB mRNA from nonsense-mediated decay


This is Transient receptor potential cation channel subfamily V member 5 protein, from Human, contains 729 amino acids, is membrane-bound, locates in Cell membrane.

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590), Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity), The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590), A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity), Heteromeric assembly with TRPV6 seems to modify channel properties, TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)

Belongs to the transient receptor (TC 1,A,4) family, TrpV subfamily, TRPV5 sub-subfamily


This is Transcription factor 7-like 2 protein, from Human, contains 619 amino acids, locates in Nucleus.

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner, Acts as repressor in the absence of CTNNB1, and as activator in its presence, Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1, TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1, Expression of dominant-negative mutants results in cell-cycle arrest in G1, Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine


This is Xaa-Pro aminopeptidase 3 protein, from Human, contains 507 amino acids, locates in Mitochondrion.

Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity, May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling


This is Solute carrier family 35 member C2 protein, from Human, contains 365 amino acids, is membrane-bound, locates in Golgi apparatus.

May play an important role in the cellular response to tissue hypoxia, May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells

Belongs to the TPT transporter family, SLC35C subfamily


This is Omega-amidase NIT2 protein, from Human, contains 276 amino acids, is soluble, locates in Cytoplasm.

Has omega-amidase activity (PubMed:22674578, PubMed:19595734), The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734)

Belongs to the carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family


This is Glucose-6-phosphatase 2 protein, from Human, contains 355 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum, May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity)

Belongs to the glucose-6-phosphatase family


This is PR domain zinc finger protein 8 protein, from Human, contains 689 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity), Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity), Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity), In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is PR domain zinc finger protein 5 protein, from Human, contains 630 amino acids, has 14 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

C2H2-type 3; atypical

Sequence-specific DNA-binding transcription factor, Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1, Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes, May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2, May cause G2/M arrest and apoptosis in cancer cells


This is Protein mono-ADP-ribosyltransferase PARP11 protein, from Human, contains 338 amino acids, locates in Nucleus.

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562), Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity)


This is Protein arginine N-methyltransferase 8 protein, from Human, contains 394 amino acids, is membrane-bound, locates in Cell membrane.

S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26876602, PubMed:26529540), Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585)

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT8 subfamily


This is Diablo IAP-binding mitochondrial protein protein, from Human, contains 239 amino acids, locates in Mitochondrion.

Defective in the capacity to down-regulate the XIAP/BIRC4 abundance


This is Nucleolar RNA helicase 2 protein, from Human, contains 783 amino acids, is soluble, locates in Nucleus.

RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157), Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060), In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification, Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391), In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060), Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534), Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305), Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157), Involved in rRNA processing (PubMed:14559904, PubMed:18180292), May bind to specific miRNA hairpins (PubMed:28431233), Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity)

Belongs to the DEAD box helicase family, DDX21/DDX50 subfamily


This is Endophilin-B2 protein, from Human, contains 395 amino acids, is soluble, locates in Cytoplasm.


This is Basic leucine zipper transcriptional factor ATF-like 3 protein, from Human, contains 127 amino acids, locates in Nucleus.

AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system, Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity), Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes


This is Neutral ceramidase protein, from Human, contains 780 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575), Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:15946935, PubMed:19345744, PubMed:24798654), Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:11278489, PubMed:17475390), Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16061940), Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity), This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity)

Belongs to the neutral ceramidase family


This is Eukaryotic translation initiation factor 4E transporter protein, from Human, contains 985 amino acids, locates in Cytoplasm.

EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837), Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837), Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837), Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity), Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484), Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837), Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837), Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671)


This is F-box only protein 6 protein, from Human, contains 293 amino acids, is soluble, locates in Cytoplasm.

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes, Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation, Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides, Also recognizes sulfated glycans, Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation, Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication


This is Aladin protein, from Human, contains 546 amino acids, locates in Nucleus.

Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285), Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606)


This is L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase protein, from Human, contains 309 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the post-translational modification of target proteins by phosphopantetheine, Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN

Belongs to the P-Pant transferase superfamily, AcpS family


This is Protein kish-B protein, from Human, contains 74 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in the early part of the secretory pathway


This is SOSS complex subunit C protein, from Human, contains 104 amino acids, locates in Nucleus.

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint, The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability, Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways


This is Phospholipid scramblase 3 protein, from Human, contains 295 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662), Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167), Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005), Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232), Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411)

Belongs to the phospholipid scramblase family


This is Phospholipid scramblase 2 protein, from Human, contains 297 amino acids, is membrane-bound, locates in Nucleus.

Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain


This is CREB/ATF bZIP transcription factor protein, from Human, contains 354 amino acids, locates in Nucleus.

Strongly activates transcription when bound to HCFC1, Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner, Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell, Able to down-regulate expression of some cellular genes in CREBZF-expressing cells

Belongs to the bZIP family, ATF subfamily


This is Sodium- and chloride-dependent GABA transporter 2 protein, from Human, contains 602 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902), Mediates transport of beta-alanine (PubMed:17502375), Can also mediate transport of taurine and hypotaurine (By similarity)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A13 subfamily


This is NAD-dependent protein deacetylase sirtuin-3, mitochondrial protein, from Human, contains 399 amino acids, is soluble, locates in Mitochondrion.

NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340), Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090), Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340), Contributes to the regulation of the cellular energy metabolism (PubMed:24252090), Important for regulating tissue-specific ATP levels (PubMed:18794531), In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301), Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity)

Belongs to the sirtuin family, Class I subfamily


This is Protein DEPP1 protein, from Human, contains 212 amino acids, is soluble, locates in Cytoplasm.

Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS


This is Obg-like ATPase 1 protein, from Human, contains 396 amino acids, locates in Cytoplasm.

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency, Has lower affinity for GTP

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, YchF/OLA1 subfamily


This is GPI mannosyltransferase 2 protein, from Human, contains 493 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis, Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly


This is Lysosomal cobalamin transport escort protein LMBD1 protein, from Human, contains 540 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

(Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV)

Belongs to the LIMR family, LMBRD1 subfamily


This is Mitochondrial potassium channel ATP-binding subunit protein, from Human, contains 735 amino acids, is membrane-bound, locates in Mitochondrion.

ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (PubMed:31435016), Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (PubMed:31435016), Plays a role in mitochondrial iron transport (PubMed:30623799), Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes (By similarity)

Belongs to the ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3,A,1,201) subfamily


This is GTPase IMAP family member 4 protein, from Human, contains 329 amino acids, is soluble, locates in Cytoplasm.

During thymocyte development, may play a role in the regulation of apoptosis (By similarity), GTPase which exhibits a higher affinity for GDP than for GTP

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily


This is DDB1- and CUL4-associated factor 13 protein, from Human, contains 445 amino acids, locates in Nucleus.

Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:16949367, PubMed:30111536, PubMed:31492966), Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity), Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979), Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536), Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966), Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity)

Belongs to the WD repeat DCAF13/WDSOF1 family


This is U3 small nucleolar ribonucleoprotein protein IMP3 protein, from Human, contains 184 amino acids, locates in Nucleus.

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP), Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Belongs to the universal ribosomal protein uS4 family


This is DnaJ homolog subfamily C member 11 protein, from Human, contains 559 amino acids, locates in Mitochondrion.

Required for mitochondrial inner membrane organization, Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex


This is Integrator complex subunit 13 protein, from Human, contains 706 amino acids, is soluble, locates in Cytoplasm.

Crucial regulator of the mitotic cell cycle and development, At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling, At G2/M phase, may be required for proper spindle formation and execution of cytokinesis, Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267)


This is Synembryn-B protein, from Human, contains 520 amino acids, is soluble, locates in Cytoplasm.

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP, Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction


This is ATP-dependent RNA helicase DDX18 protein, from Human, contains 670 amino acids, locates in Nucleus.

Belongs to the DEAD box helicase family, DDX18/HAS1 subfamily


This is Histone chaperone ASF1B protein, from Human, contains 202 amino acids, locates in Nucleus.

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279), Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251), Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279), Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251), Required for gonad development (PubMed:12842904)


This is Protein kintoun protein, from Human, contains 837 amino acids, is soluble, locates in Cytoplasm.

Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella, Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment

Belongs to the PIH1 family, Kintoun subfamily


This is Protein SDA1 homolog protein, from Human, contains 687 amino acids, locates in Nucleus.

Required for 60S pre-ribosomal subunits export to the cytoplasm


This is THAP domain-containing protein 1 protein, from Human, contains 213 amino acids, has 1 THAP-type Zinc finger, is soluble, locates in Nucleus.

THAP-type

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression, Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1, Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1, May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis


This is E3 ubiquitin-protein ligase RLIM protein, from Human, contains 624 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase, Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex, Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM, Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1, By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals


This is HAUS augmin-like complex subunit 2 protein, from Human, contains 235 amino acids, is soluble, locates in Cytoplasm.

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex


This is Notchless protein homolog 1 protein, from Human, contains 485 amino acids, locates in Nucleus.

Plays a role in regulating Notch activity, Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity, Required during embryogenesis for inner mass cell survival (By similarity)


This is RNA-binding protein 28 protein, from Human, contains 759 amino acids, locates in Nucleus.

Nucleolar component of the spliceosomal ribonucleoprotein complexes


This is Anoctamin-10 protein, from Human, contains 660 amino acids, is membrane-bound, locates in Cell membrane.

Does not exhibit calcium-activated chloride channel (CaCC) activity, Can inhibit the activity of ANO1


This is G patch domain-containing protein 2 protein, from Human, contains 528 amino acids, locates in Nucleus.

Enhances the ATPase activity of DHX15 in vitro


This is Solute carrier family 52, riboflavin transporter, member 1 protein, from Human, contains 448 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A)

Belongs to the riboflavin transporter family


This is Peptidyl-prolyl cis-trans isomerase FKBP14 protein, from Human, contains 211 amino acids, is soluble, locates in Endoplasmic reticulum.

PPIase which accelerates the folding of proteins during protein synthesis, Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen, May also target type VI and type X collagens


This is Uncharacterized protein C14orf119 protein, from Human, contains 140 amino acids, locates in Mitochondrion.


This is Calcium uniporter regulatory subunit MCUb, mitochondrial protein, from Human, contains 336 amino acids, is membrane-bound, locates in Mitochondrion.

Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion, Does not form functional calcium channels by itself, Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways


This is p21-activated protein kinase-interacting protein 1 protein, from Human, contains 392 amino acids, locates in Nucleus.

Negatively regulates the PAK1 kinase, PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA, PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain, PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42, May be involved in ribosomal large subunit assembly (PubMed:24120868)


This is 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial protein, from Human, contains 459 amino acids, locates in Mitochondrion.

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function

Belongs to the thiolase-like superfamily, Beta-ketoacyl-ACP synthases family


This is Glucose-induced degradation protein 8 homolog protein, from Human, contains 228 amino acids, locates in Nucleus.

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972), Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation (PubMed:28829046)


This is Ceroid-lipofuscinosis neuronal protein 6 protein, from Human, contains 311 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Probable tRNA(His) guanylyltransferase protein, from Human, contains 298 amino acids, is soluble, locates in Cytoplasm.

Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage, This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable), Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion (PubMed:25008184, PubMed:27307223), By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress (PubMed:25008184, PubMed:27307223)

Belongs to the tRNA(His) guanylyltransferase family


This is Interleukin-1 receptor-associated kinase 4 protein, from Human, contains 460 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens, Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374), Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2, Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1, Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1, Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex, In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation, Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation, Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily


This is Thioredoxin-like protein 4B protein, from Human, contains 149 amino acids, locates in Nucleus.

Essential role in pre-mRNA splicing, Required in cell cycle progression for S/G(2) transition


This is Rhomboid-related protein 2 protein, from Human, contains 303 amino acids, is membrane-bound, locates in Cell membrane.

Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors, Known substrate: EFNB3


This is Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase protein, from Human, contains 359 amino acids, is membrane-bound, locates in Golgi apparatus.

Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate, May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation, Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4

Belongs to the inositol monophosphatase superfamily


This is Mediator of RNA polymerase II transcription subunit 29 protein, from Human, contains 200 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Belongs to the Mediator complex subunit 29 family


This is Elongation of very long chain fatty acids protein 2 protein, from Human, contains 296 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle, This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle, Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA, May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators

Belongs to the ELO family, ELOVL2 subfamily


This is Palmitoyltransferase ZDHHC7 protein, from Human, contains 308 amino acids, is membrane-bound, locates in Golgi apparatus.

Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865), Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity), Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296), Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095), Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068), In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321), Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865), Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity), In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity), Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity), Could also palmitoylate NCDN (By similarity), May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity)

Belongs to the DHHC palmitoyltransferase family


This is Transmembrane prolyl 4-hydroxylase protein, from Human, contains 502 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, Hydroxylates HIF1A at 'Pro-402' and 'Pro-564', May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex


This is Glutaminyl-peptide cyclotransferase-like protein protein, from Human, contains 382 amino acids, is membrane-bound, locates in Golgi apparatus.

Responsible for the biosynthesis of pyroglutamyl peptides

Belongs to the glutaminyl-peptide cyclotransferase family


This is CDKN2A-interacting protein protein, from Human, contains 580 amino acids, is soluble, locates in Nucleus.

Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence


This is Non-structural maintenance of chromosomes element 4 homolog A protein, from Human, contains 385 amino acids, locates in Nucleus.

Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination, The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks, The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs), Is involved in positive regulation of response to DNA damage stimulus


This is C-type lectin domain family 5 member A protein, from Human, contains 188 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123), The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526), This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release (PubMed:18496526)


This is Protein AATF protein, from Human, contains 560 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797), May function as a general inhibitor of the histone deacetylase HDAC1, Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression, Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression, Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date


This is Ewing's tumor-associated antigen 1 protein, from Human, contains 926 amino acids, is soluble, locates in Cytoplasm.

Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717), Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717), Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717)


This is Probable ATP-dependent RNA helicase DDX56 protein, from Human, contains 547 amino acids, locates in Nucleus.

(Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation

Belongs to the DEAD box helicase family, DDX56/DBP9 subfamily


This is Solute carrier organic anion transporter family member 1C1 protein, from Human, contains 712 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463), Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113), Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113), Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463), Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463), Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914)

Belongs to the organo anion transporter (TC 2,A,60) family


This is Potassium channel subfamily K member 4 protein, from Human, contains 393 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-insensitive potassium channel (PubMed:22282805), Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157, PubMed:30290154), Channel opening is triggered by raising the intracellular pH to basic levels (By similarity), The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity), Plays a role in the perception of pain caused by heat (By similarity), Plays a role in the sensory perception of pain caused by pressure (By similarity)

Belongs to the two pore domain potassium channel (TC 1,A,1,8) family


This is U3 small nucleolar RNA-associated protein 6 homolog protein, from Human, contains 597 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome, Involved in nucleolar processing of pre-18S ribosomal RNA


This is Protein Mis18-alpha protein, from Human, contains 233 amino acids, locates in Nucleus.

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis


This is NF-kappa-B inhibitor-interacting Ras-like protein 1 protein, from Human, contains 192 amino acids, is soluble, locates in Cytoplasm.

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation, May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit, It is unclear whether it acts as a GTPase, Both GTP- and GDP-bound forms block phosphorylation of NFKBIB

Belongs to the small GTPase superfamily, Ras family, KappaB-Ras subfamily


This is RNA polymerase I-specific transcription initiation factor RRN3 protein, from Human, contains 651 amino acids, locates in Nucleus.

Required for efficient transcription initiation by RNA polymerase I, Required for the formation of the competent preinitiation complex (PIC), Dissociates from pol I as a consequence of transcription, In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity)


This is Taste receptor type 2 member 16 protein, from Human, contains 291 amino acids, is membrane-bound, locates in Cell membrane.

Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract, Signals through PLCB2 and the calcium-regulated cation channel TRPM5

Belongs to the G-protein coupled receptor T2R family


This is RB-associated KRAB zinc finger protein protein, from Human, contains 714 amino acids, has 15 C2H2-type Zinc finger, has 1 C2H2-type 10; degenerate Zinc finger, locates in Nucleus.

C2H2-type 10; degenerate

May repress E2F-dependent transcription, May promote AR-dependent transcription

Belongs to the krueppel C2H2-type zinc-finger protein family


This is FAST kinase domain-containing protein 2, mitochondrial protein, from Human, contains 710 amino acids, is soluble, locates in Mitochondrion.

Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715), As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664, PubMed:25683715, PubMed:26370583), May play a role in mitochondrial apoptosis


This is Very-long-chain enoyl-CoA reductase protein, from Human, contains 308 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (PubMed:25049234), Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (PubMed:12482854), This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (PubMed:12482854), This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (PubMed:12482854), Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (PubMed:12482854), Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (PubMed:25049234)

Belongs to the steroid 5-alpha reductase family


This is Vesicle transport protein USE1 protein, from Human, contains 259 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER


This is CDGSH iron-sulfur domain-containing protein 1 protein, from Human, contains 108 amino acids, is membrane-bound, locates in Mitochondrion.

L-cysteine transaminase that catalyzes the reversible transfer of the amino group from L-cysteine to the alpha-keto acid 2-oxoglutarate to respectively form 2-oxo-3-sulfanylpropanoate and L-glutamate (PubMed:36194135), The catalytic cycle occurs in the presence of pyridoxal 5'-phosphate (PLP) cofactor that facilitates transamination by initially forming an internal aldimine with the epsilon-amino group of active site Lys-55 residue on the enzyme (PLP-enzyme aldimine), subsequently displaced by formation of an external aldimine with the substrate amino group (PLP-L-cysteine aldimine), The external aldimine is further deprotonated to form a carbanion intermediate, which in the presence of 2-oxoglutarate regenerates PLP yielding final products 2-oxo-3-sulfanylpropanoate and L-glutamate, The proton transfer in carbanion intermediate is suggested to be controlled by the active site lysine residue, whereas PLP stabilizes carbanion structure through electron delocalization, also known as the electron sink effect (PubMed:36194135), Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity), May be involved in iron-sulfur cluster shuttling and/or in redox reactions, Can transfer the [2Fe-2S] cluster to an apo-acceptor protein only when in the oxidation state, likely serving as a redox sensor that regulates mitochondrial iron-sulfur cluster assembly and iron trafficking upon oxidative stress (PubMed:21788481, PubMed:23758282, PubMed:17584744)


This is Proline-rich protein 13 protein, from Human, contains 148 amino acids, locates in Nucleus.

Negatively regulates TSP1 expression at the level of transcription, This down-regulation was shown to reduce taxane-induced apoptosis