This is Target of rapamycin complex 1 subunit tco89 protein, from Fission yeast, contains 451 amino acids, is soluble, locates in Cytoplasm.

Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals, Tor2 is essential for growth, Nutrient limitation and environmental stress signals cause inactivation of TORC1, Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression, TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake, Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2

Belongs to the TORC subunit TCO89 family


This is Meiotically up-regulated gene 33 protein protein, from Fission yeast, contains 336 amino acids, is soluble, locates in Cytoplasm.


This is Histone chaperone cia1 protein, from Fission yeast, contains 262 amino acids, locates in Nucleus.

Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly


This is Probable serine/threonine-protein kinase C70.05c protein, from Fission yeast, contains 781 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+] protein, from Fission yeast, contains 326 amino acids, locates in Mitochondrion.

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057), Also able to mediate dihydrouridylation of some mRNAs, thereby affecting their translation (PubMed:34798057)

Belongs to the Dus family, Dus4 subfamily


This is Nuclear distribution protein nudE protein, from Aspergillus nidulans, contains 586 amino acids, is soluble, locates in Cytoplasm.

Required for nuclear migration within hyphae during vegetative growth


This is Endo-1,4-beta-xylanase 1 protein, from Ergot fungus, contains 216 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is Telomere elongation protein est1 protein, from Fission yeast, contains 490 amino acids, locates in Nucleus.

Directly involved in telomere replication, Associates with telomerase and during its interaction with trt1, telomerase activity is promoted


This is 5-demethoxyubiquinone hydroxylase, mitochondrial protein, from Fission yeast, contains 216 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis, Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides


This is Set1 complex component sdc1 protein, from Fission yeast, contains 109 amino acids, locates in Nucleus.

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance


This is Acyl-coenzyme A oxidase 1 protein, from Yeast, contains 689 amino acids, locates in Peroxisome.


This is Acyl-coenzyme A oxidase 2 protein, from Yeast, contains 700 amino acids, locates in Peroxisome.

Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons, Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group


This is Acyl-coenzyme A oxidase 3 protein, from Yeast, contains 700 amino acids, locates in Peroxisome.

Oxidizes aliphatic acyl-CoA substrates of different chain lengths such as hexanoyl-CoA, decanoyl-CoA and myristoyl-CoA as well as aromatic/heterocyclic ring-substituted chromogenic substrates, such as furylpropionyl-CoA, Of the above substrates, the efficiency of the enzyme, exhibits the following order: decanoyl-CoA > myristoyl-CoA > hexanoyl-CoA > furyl-propionyl-CoA


This is U1 small nuclear ribonucleoprotein usp102 protein, from Fission yeast, contains 249 amino acids, locates in Nucleus.


This is Small ribosomal subunit protein mS37 protein, from Baker's yeast, contains 95 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the mitochondrion-specific ribosomal protein mS37 family


This is Peptide chain release factor 1, mitochondrial protein, from Human, contains 445 amino acids, locates in Mitochondrion.

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA

Belongs to the prokaryotic/mitochondrial release factor family


This is C-type lectin domain family 3 member A protein, from Human, contains 197 amino acids, is soluble, locates in Extracellular.

Promotes cell adhesion to laminin-332 and fibronectin


This is Delta-ctenitoxin-Pn2c protein, from Brazilian armed spider, contains 82 amino acids, is soluble, locates in Extracellular.

Reversible inhibitor of voltage-gated sodium channels (Nav), Delays the fast inactivation kinetics of neuronal-type sodium channels, In vivo, it induces rat penile erection (PubMed:15246765), This effect may be due to the neuronal nitric oxide synthase (NOS1), since one of its selective inhibitor completely abolishes all the toxic effects of the toxin (PubMed:15246765), This toxin also causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 0,24 mg/mouse (PubMed:1397265, PubMed:16278100, PubMed:15246765), It is also insecticidal to the larval and adult forms of the house fly (PubMed:1397265)

Belongs to the neurotoxin 03 (Tx2) family, 06 subfamily


This is Acetylcholine receptor subunit alpha-type des-2 protein, from Caenorhabditis elegans, contains 548 amino acids, is membrane-bound, locates in Cell membrane.

Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline, After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily


This is Toxin Ts4 protein, from Brazilian scorpion, contains 84 amino acids, is soluble, locates in Extracellular.

Not toxic, Induces an immune response similar to that induced by whole venom, Induces a dose dependent release of the neurotransmitters glutamic acid and gamma aminobutyric acid from rat brain synaptosomes, Thus, polyclonal antibodies raised against this protein can neutralize the effects of the venom

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily


This is Ferredoxin-2, chloroplastic protein, from Maize, contains 140 amino acids, locates in Plastid.

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions, Occupies a key position both for transferring the photoreducing power to Fd-NADP(+) oxidoreductase (FNR), hence the formation of NADPH, and for mediating the cyclic electron flow around photosystem I (PSI)

Belongs to the 2Fe2S plant-type ferredoxin family


This is Calmodulin-binding protein 25 protein, from Mouse-ear cress, contains 238 amino acids, locates in Nucleus.

Calmodulin-binding protein that functions as a negative regulator of osmotic stress tolerance


This is ADP-ribosylation factor GTPase-activating protein AGD7 protein, from Mouse-ear cress, contains 456 amino acids, has 1 C4-type Zinc finger, locates in Golgi apparatus.

GTPase-activating protein (GAP) for ADP ribosylation factor (ARF), Involved in protein trafficking by controlling ARF1 activity; may participate in COPI vesicle formation at the Golgi complex


This is DNA-directed RNA polymerases II and IV subunit 5A protein, from Mouse-ear cress, contains 205 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, Component of RNA polymerase IV which mediates short-interfering RNAs (siRNA) accumulation and subsequent RNA-directed DNA methylation-dependent (RdDM) transcriptional gene silencing (TGS) of target sequences

Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family


This is Scarecrow-like protein 6 protein, from Mouse-ear cress, contains 558 amino acids, locates in Nucleus.

Probable transcription factor involved in plant development


This is Iron-sulfur cluster assembly protein 3 protein, from Mouse-ear cress, contains 171 amino acids, is soluble, locates in Mitochondrion.

Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:17417719), First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU (ISU1, ISU2 or ISU3), In a second step, the cluster is released from ISCU, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins, Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity)


This is PHD finger protein ALFIN-LIKE 4 protein, from Mouse-ear cress, contains 255 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Villin-2 protein, from Mouse-ear cress, contains 976 amino acids, is soluble, locates in Cytoplasm.

Ca(2+)-regulated actin-binding protein, Involved in actin filaments bundling, Caps the barbed end of actin filaments and is able to sever them in a calcium-dependent manner, Required for the construction of actin collars in pollen tubes, Acts redundantly with VLN5 (AC Q9LVC6) to generate thick actin filament bundles and to regulate polarized pollen tube growth (PubMed:23715472), Acts redundantly with VLN3 (AC O81645) to regulate directional organ growth and in sclerenchyma development (PubMed:22209875, PubMed:22563899)


This is Protein HAIKU1 protein, from Mouse-ear cress, contains 402 amino acids, locates in Nucleus.

Modulates seed size by negatively regulating the cellularization of syncytial endosperm (PubMed:12692325, PubMed:20545893), May function by binding and modulating the activity of WRKY10 transcription factor (PubMed:20545893)


This is Protein TIC 20-II, chloroplastic protein, from Mouse-ear cress, contains 208 amino acids, is membrane-bound, locates in Plastid.

May be involved in protein precursor import into chloroplasts, Not redundant with TIC20-I, TIC20-IV or TIC20-V


This is Aquaporin TIP4-1 protein, from Mouse-ear cress, contains 249 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes, Transports urea in yeast cells in a pH-independent manner

Belongs to the MIP/aquaporin (TC 1,A,8) family, TIP (TC 1,A,8,10) subfamily


This is 3-methyl-2-oxobutanoate hydroxymethyltransferase 1, mitochondrial protein, from Mouse-ear cress, contains 347 amino acids, locates in Mitochondrion.

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate


This is Pentatricopeptide repeat-containing protein At2g29760, chloroplastic protein, from Mouse-ear cress, contains 738 amino acids, locates in Plastid.

Involved in RNA editing event in chloroplasts, Required for the editing of a single site in rps12 transcript

Belongs to the PPR family, PCMP-H subfamily


This is V-type proton ATPase subunit G1 protein, from Mouse-ear cress, contains 110 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase), V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Belongs to the V-ATPase G subunit family


This is Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial protein, from Mouse-ear cress, contains 421 amino acids, locates in Mitochondrion.

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA, The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit

Belongs to the succinate/malate CoA ligase beta subunit family


This is Small rubber particle protein protein, from Para rubber tree, contains 204 amino acids, is soluble, locates in Cytoplasm.

Involved in the biosynthesis of rubber, an isoprenoid polymer (cis-1,4-polyisoprene)


This is Metaxin-2 protein, from Mouse, contains 263 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in transport of proteins into the mitochondrion


This is Phosphofurin acidic cluster sorting protein 1 protein, from Rat, contains 961 amino acids, locates in Golgi apparatus.

Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs, Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits, Required for normal ER Ca2+ handling in lymphocytes, Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival, Required for stabilizing peripheral lymphocyte populations (By similarity)


This is Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase protein, from Rat, contains 474 amino acids, is membrane-bound, locates in Cell membrane.

Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation, Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity), When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (PubMed:9722534, PubMed:14525949), Has a role in maintenance of cochlear outer hair cell function (By similarity)

Belongs to the ALG10 glucosyltransferase family


This is Mannosyl-oligosaccharide glucosidase protein, from Rat, contains 834 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner

Belongs to the glycosyl hydrolase 63 family


This is Ectonucleoside triphosphate diphosphohydrolase 8 protein, from Chicken, contains 493 amino acids, is membrane-bound, locates in Cell membrane.

Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity, Ectonucleoside ATPases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides


This is Histone-binding protein RBBP4-A protein, from African clawed frog, contains 425 amino acids, locates in Nucleus.

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10454532), Component of several complexes which regulate chromatin metabolism (By similarity)

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family


This is Endo-1,4-beta-xylanase F1 protein, from Yellow koji mold, contains 327 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Exportin-T protein, from Fission yeast, contains 978 amino acids, locates in Cytoplasm.

tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex, Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity)


This is Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 protein, from Fission yeast, contains 551 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P

In the C-terminal section; belongs to the thiaminase-2 family


This is 25S rRNA (cytosine-C(5))-methyltransferase nop2 protein, from Fission yeast, contains 608 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA, Required for 60S ribosomal subunit synthesis and processing (By similarity)

Belongs to the class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family


This is Peptidyl-prolyl cis-trans isomerase B protein, from Fission yeast, contains 201 amino acids, is soluble, locates in Endoplasmic reticulum.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)

Belongs to the cyclophilin-type PPIase family, PPIase B subfamily


This is U2 snRNP component ist3 protein, from Fission yeast, contains 217 amino acids, locates in Nucleus.

Required for pre-mRNA splicing and spliceosome assembly


This is Sphingolipid C4-hydroxylase sur2 protein, from Fission yeast, contains 293 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for hydroxylation of C-4 in the sphingoid moiety of ceramide, Involved in the response to syringomycin (By similarity)


This is Probable prefoldin subunit 5 protein, from Fission yeast, contains 154 amino acids, is soluble, locates in Cytoplasm.

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it, Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity), Required for normal cytoskeletal function and when bound to byr1, is involved in the regulation of sexual differentiation

Belongs to the prefoldin subunit alpha family


This is Aspartate aminotransferase, mitochondrial protein, from Fission yeast, contains 437 amino acids, is soluble, locates in Mitochondrion.

Plays a key role in amino acid metabolism, Important for metabolite exchange between mitochondria and cytosol (By similarity)

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is NURS complex subunit pir2 protein, from Fission yeast, contains 609 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.


This is DNA replication complex GINS protein psf2 protein, from Fission yeast, contains 183 amino acids, locates in Nucleus.

The GINS complex plays an essential role in the initiation of DNA replication, Has a role in chromosome segregation and is required for bir1 localization


This is Arginine biosynthesis bifunctional protein ArgJ, mitochondrial protein, from Fission yeast, contains 445 amino acids, is soluble, locates in Mitochondrion.

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate


This is Argininosuccinate synthase protein, from Fission yeast, contains 410 amino acids, is soluble, locates in Cytoplasm.

Belongs to the argininosuccinate synthase family, Type 1 subfamily


This is Transcriptional regulatory protein rxt2 protein, from Fission yeast, contains 240 amino acids, locates in Nucleus.

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity)


This is SAGA-associated factor 73 protein, from Fission yeast, contains 344 amino acids, locates in Nucleus.

Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination, SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), Sgf11 is involved in transcriptional regulation of a subset of SAGA-regulated genes and is required for histone H2B deubiquitination (By similarity)


This is Ribose-phosphate pyrophosphokinase 2 protein, from Fission yeast, contains 321 amino acids, is soluble, locates in Cytoplasm.

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis, Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity)

Belongs to the ribose-phosphate pyrophosphokinase family


This is Meiotic fizzy-related protein 1 protein, from Fission yeast, contains 421 amino acids, locates in Nucleus.

Meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C), Involved in cdc13 degradation

Belongs to the WD repeat CDC20/Fizzy family


This is Nucleus-vacuole junction protein 2 protein, from Fission yeast, contains 779 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, induces contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation


This is Alkylbase DNA glycosidase-like protein mag2 protein, from Fission yeast, contains 213 amino acids, locates in Nucleus.

Alkylbase DNA glycosidase-like protein that shows no DNA glycosylase activity for alkylated bases (PubMed:23273506, PubMed:23245849), The molecular role of mag2 appears to be abasic (AP) site recognition and protection, while possibly facilitating damage signaling by structurally sculpting the DNA substrate (PubMed:18270439, PubMed:23245849), Stimulates AP site binding to mismatch repair protein mutS (PubMed:23245849)

Belongs to the alkylbase DNA glycosidase AlkA family


This is Chromatin structure-remodeling complex subunit rsc7 protein, from Fission yeast, contains 390 amino acids, locates in Nucleus.

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, Controls particularly membrane and organelle development genes

Belongs to the RSC7/SWP82 family, RSC7 subfamily


This is U4/U6.U5 tri-snRNP-associated protein snu66 protein, from Fission yeast, contains 649 amino acids, locates in Nucleus.

Required for efficient splicing of pre-mRNA


This is Serine/threonine-protein kinase ppk24, mitochondrial protein, from Fission yeast, contains 461 amino acids, locates in Mitochondrion.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Syntaxin pep12 protein, from Fission yeast, contains 263 amino acids, locates in Endoplasmic reticulum.

Has a role in vesicle-mediated transport but not with protein transport from Golgi to vesicle


This is GTPase-activating protein gyp10 protein, from Fission yeast, contains 373 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Has a role in vesicular trafficking and septation during cytokinesis


This is RNA polymerase-associated protein C651.09c protein, from Fission yeast, contains 560 amino acids, is soluble, locates in Nucleus.

The PAF1 complex is a multifunctional complex, Involved in transcription initiation via genetic interactions with TATA-binding proteins, Involved in elongation, Also has a role in transcription-coupled histone modification, Important for TATA site selection by TBP, Directly or indirectly regulates the DNA-binding properties of the TATA box-binding protein, and the relative activities of different TATA elements (By similarity)


This is Charged multivesicular body protein 7 protein, from Fission yeast, contains 449 amino acids, is soluble, locates in Cytoplasm.

ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (By similarity), Plays a role in regulating nuclear envelope (NE) morphology and nuclear integrity, particularly during spindle pole body (SPB) extrusion or insertion through the NE, and perhaps during karyokinesis (PubMed:28242692)


This is Putative TGFB1-induced anti-apoptotic factor 1 protein, from Human, contains 115 amino acids, locates in Nucleus.

Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1, Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation


This is Kunitz-type serine protease inhibitor 3 protein, from Western sand viper, contains 93 amino acids, is soluble, locates in Extracellular.

Serine protease inhibitor that principally inhibits alpha-chymotrypsin (Ki=4,3 nM), Shows weak inhibition on trypsin (Ki=5100 nM), and plasma kallikrein


This is Ovalbumin-related protein Y protein, from Chicken, contains 388 amino acids, is soluble, locates in Extracellular.

Belongs to the serpin family, Ov-serpin subfamily


This is Alpha-elapitoxin-Ls2a protein, from Black-banded sea krait, contains 87 amino acids, is soluble, locates in Extracellular.

Binds with high affinity to muscular (tested on Torpedo marmorata, Kd=1,6 nM) and neuronal (chimeric alpha-7/CHRNA7, Kd=3 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:9305882), Also shows a very weak inhibition on GABA(A) receptors (PubMed:26221036), The toxin (10 uM) inhibits 83% of current in channels composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits, 39% of current in channels composed of alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits, and 33% of current in channels composed of alpha-5-beta-2-gamma-2 (GABRA5-GABRB2-GABRG2) subunits (PubMed:26221036)

Belongs to the snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily


This is Alpha-elapitoxin-Nno2a protein, from Central Asian cobra, contains 73 amino acids, is soluble, locates in Extracellular.

Binds with high affinity to muscular (tested on Torpedo marmorata AChR, Kd=0,38 nM) and neuronal (tested on chimeric alpha-7/CHRNA7, Kd=12 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission (PubMed:9305882), The toxin also shows a very weak inhibition of GABA(A) receptors composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (PubMed:26221036)


This is Toxin F-VIII protein, from Eastern green mamba, contains 81 amino acids, is soluble, locates in Extracellular.

Is cytotoxic against A549 cells (LC(50)=106 ug/ml)

Belongs to the snake three-finger toxin family, Short-chain subfamily, Orphan group XI sub-subfamily


This is Toxin CsEv2 protein, from Arizona bark scorpion, contains 87 amino acids, is soluble, locates in Extracellular.

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity), Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours, Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg)

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Toxin CsEv3 protein, from Arizona bark scorpion, contains 87 amino acids, is soluble, locates in Extracellular.


This is Large ribosomal subunit protein eL24A protein, from Baker's yeast, contains 155 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL24 family


This is Tryptophan--tRNA ligase, mitochondrial protein, from Baker's yeast, contains 379 amino acids, is soluble, locates in Mitochondrion.

Mitochondrial aminoacyl-tRNA synthetase that catalyzes the attachment of tryptophan to tRNA(Trp)

Belongs to the class-I aminoacyl-tRNA synthetase family


This is Serine protease snake protein, from Fruit fly, contains 435 amino acids, is soluble, locates in Extracellular.

Component of the extracellular signaling pathway that establishes the dorsal-ventral pathway of the embryo, Three proteases; ndl, gd and snk process easter to create active easter, Active easter defines cell identities along the dorsal-ventral continuum by activating the spz ligand for the Tl receptor in the ventral region of the embryo

Belongs to the peptidase S1 family, CLIP subfamily


This is Homeobox protein invected protein, from Fruit fly, contains 576 amino acids, locates in Nucleus.

Engrailed (en) and invected (inv) are functionally redundant transcription factors in neuronal precursor cell NB5-3 specification, Inv is unable to substitute for en in other regulatory processes such as maintaining gsb expression in the neuroectoderm after stage 10 of embryogenesis, Maintenance of gsb expression in row 5 of the neuroectoderm involves an as yet unidentified short range signaling molecule

Belongs to the engrailed homeobox family


This is Transcription factor Adf-1 protein, from Fruit fly, contains 262 amino acids, locates in Nucleus.

May play an important role not only in the regulation of Adh expression but also in the transcription of other genes


This is Leukocyte elastase inhibitor protein, from Horse, contains 379 amino acids, is soluble, locates in Cytoplasm.

Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis, Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection, These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality, Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3, Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity, During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation, When secreted, promotes the proliferation of beta-cells via its protease inhibitory function


This is Large ribosomal subunit protein uL6A protein, from Baker's yeast, contains 191 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uL6 family


This is Large ribosomal subunit protein uL24A protein, from Baker's yeast, contains 127 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uL24 family


This is Large ribosomal subunit protein eL22A protein, from Baker's yeast, contains 121 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eL22 family


This is Cytochrome B pre-mRNA-processing protein 6 protein, from Baker's yeast, contains 162 amino acids, locates in Mitochondrion.

This protein is involved in processing of the 5' terminus and the intervening sequences of cytochrome b pre-mRNA


This is Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial protein, from Baker's yeast, contains 575 amino acids, is membrane-bound, locates in Mitochondrion.

Belongs to the aldehyde dehydrogenase family


This is Galanin peptides protein, from Pig, contains 123 amino acids, is soluble, locates in Extracellular.

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3, This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion


This is Protein zerknuellt 1 protein, from Fruit fly, contains 353 amino acids, locates in Nucleus.

Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation


This is Conotoxin tx3h protein, from Cloth-of-gold cone, contains 71 amino acids, is soluble, locates in Extracellular.


This is Cyclin-O protein, from Mouse, contains 352 amino acids, is soluble, locates in Cytoplasm.

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation, Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking (By similarity), May be involved in apoptosis in lymphoid cells; however, this result requires additional evidences in vivo, May be involved in oocyte meiotic resumption in oocytes


This is Large ribosomal subunit protein eL27A protein, from Baker's yeast, contains 136 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eL27 family


This is Large ribosomal subunit protein eL31B protein, from Baker's yeast, contains 113 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eL31 family


This is Cell division cycle-associated protein 3 protein, from African clawed frog, contains 363 amino acids, is soluble, locates in Cytoplasm.

F-box-like protein which is required for entry into mitosis, Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase


This is Protein tweety homolog 1 protein, from Rat, contains 450 amino acids, is membrane-bound, locates in Cell membrane.

Probable chloride channel, May be involved in cell adhesion


This is Myelin P2 protein protein, from Horse, contains 132 amino acids, is soluble, locates in Cytoplasm.

May play a role in lipid transport protein in Schwann cells, May bind cholesterol

Belongs to the calycin superfamily, Fatty-acid binding protein (FABP) family


This is Prosalusin protein, from Rat, contains 231 amino acids, is soluble, locates in Extracellular.

Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis, Salusin may also be a potent hypotensive peptide (By similarity)

Belongs to the ClpA/ClpB family, Torsin subfamily


This is Omega-oxotoxin-Ol1a protein, from Lynx spider, contains 69 amino acids, is soluble, locates in Extracellular.

Weak blocker of vertebrate P/Q-, N- and L-type voltage-gated calcium channels (Cav1 and Cav2), Is both paralytic and lethal when injected into lepidopteran larvae, Is not toxic to mice

Belongs to the spiderine family, Spiderine subfamily


This is Protein LURE 1.4 protein, from Mouse-ear cress, contains 90 amino acids, is soluble, locates in Extracellular.

Pollen tube attractants guiding pollen tubes to the ovular micropyle


This is Chromosome transmission fidelity protein 8 homolog protein, from Human, contains 121 amino acids, locates in Nucleus.

Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission, Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5, The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA), The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA, It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression


This is (E)-beta-ocimene synthase, chloroplastic protein, from Mouse-ear cress, contains 589 amino acids, locates in Plastid.

Predominantly involved in monoterpene (C10) biosynthesis, Using GPP as substrate, the major product is (E)-beta-ocimene with minor amounts of (Z)-beta-ocimene and myrcene, Using FPP as substrate, could also be able to synthesize in vitro sesquiterpenes (C15) with (E,E)-alpha-farnesene as the major product and with (Z,E)-alpha-farnesene and (E,E)-beta-farnesene as minor products

Belongs to the terpene synthase family, Tpsb subfamily


This is Endo-1,4-beta-xylanase 1 protein, from Crabgrass-specific blast fungus, contains 233 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Accounts for approximately 70 percent of the endoxylanase activity in the culture filtrate

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is (3S,6E)-nerolidol synthase 1 protein, from Strawberry, contains 519 amino acids, is soluble, locates in Cytoplasm.

Involved in monoterpene (C10) and sesquiterpene (C15) biosynthesis, Converts geranyl diphosphate (GPP) into S-linalool and farnesyl diphosphate (FPP) into (3S)-E-nerolidol, Exclusively present and highly expressed in the fruit of cultivated (octaploid) varieties

Belongs to the terpene synthase family, Tpsg subfamily


This is Oligo-1,6-glucosidase IMA3 protein, from Baker's yeast, contains 589 amino acids, is soluble, locates in Cytoplasm.

Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides, Not required for isomaltose utilization, but overexpression allows the IMA1 null mutant to grow on isomaltose

Belongs to the glycosyl hydrolase 13 family


This is Large ribosomal subunit protein eL20A protein, from Baker's yeast, contains 172 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL20 family


This is Large ribosomal subunit protein eL43A protein, from Baker's yeast, contains 92 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eL43 family


This is Large ribosomal subunit protein eL43B protein, from Baker's yeast, contains 92 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.


This is Small ribosomal subunit protein eS30A protein, from Baker's yeast, contains 63 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eS30 family


This is Small ribosomal subunit protein eS30B protein, from Baker's yeast, contains 63 amino acids, is soluble, locates in Cytoplasm.


This is Small ribosomal subunit protein uS9B protein, from Baker's yeast, contains 143 amino acids, is soluble, locates in Cytoplasm.

Belongs to the universal ribosomal protein uS9 family


This is Protein FRIGIDA protein, from Mouse-ear cress, contains 609 amino acids, locates in Nucleus.

Required for the regulation of flowering time in the late-flowering phenotype, Involved in the enrichment of a WDR5A-containing COMPASS-like complex at the 'FLOWERING LOCUS C' that trimethylates histone H3 'Lys-4', leading to FLC up-regulation and RNA levels increase (PubMed:19567704), Variants with an early-flowering phenotype (Including cv, Columbia, cv, Landsberg Erecta and cv, Wassilewskija) show loss-of-function mutations of FRI, Able to delay flowering independently of FRL1 activity, Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development, Suppresses the repression of FLC by the autonomous pathway, but has no effect on the expression of the genes involved in this pathway


This is V-type proton ATPase subunit c3 protein, from Mouse-ear cress, contains 164 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase, V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Belongs to the V-ATPase proteolipid subunit family


This is Phi-liotoxin-Lw1a protein, from Australian rainforest scorpion, contains 75 amino acids, is soluble, locates in Extracellular.

Affects the activity of both ryanodine-sensitive calcium-release channels RyR1 and RyR2 with high potency, At lower concentrations the toxin increases full openings of the RyRs, and at higher concentrations it inhibits full openings and induce openings to subconductance levels and reduces the number of full conductance openings, The different actions may be attributed to the toxins binding at different sites on the RyRs, with binding at a high-affinity site mediating the increase in full openings and the induction of subconductance states evoked upon binding to a lower-affinity site, Insect-selective toxin that provokes a dose-dependent contractile paralysis in crickets and blowfly larvae, followed by death


This is Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 2, mitochondrial protein, from Mouse-ear cress, contains 326 amino acids, locates in Mitochondrion.

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell, Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential)


This is Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 3, mitochondrial protein, from Mouse-ear cress, contains 326 amino acids, locates in Mitochondrion.


This is Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 4, mitochondrial protein, from Mouse-ear cress, contains 326 amino acids, locates in Mitochondrion.


This is Phosphoglycolate phosphatase 1A, chloroplastic protein, from Mouse-ear cress, contains 362 amino acids, locates in Plastid.

Photorespiratory enzyme that dephosphorylates the 2-phosphoglycolate produced by the RuBisCO oxygenation reaction

Belongs to the HAD-like hydrolase superfamily, CbbY/CbbZ/Gph/YieH family


This is Polycomb group protein FERTILIZATION-INDEPENDENT SEED 2 protein, from Mouse-ear cress, contains 813 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Polycomb group (PcG) protein, PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development, PcG proteins are not required to initiate repression, but to maintain it during later stages of development, They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility, Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization, Regulates the anteroposterior organization of the endosperm

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is Dynein regulatory complex protein 1 protein, from Chlamydomonas smithii, contains 698 amino acids, is soluble, locates in Cytoplasm.

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes, Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes, Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23427265, PubMed:25411337, PubMed:29167384, PubMed:23354437)


This is Delta/omega-plectoxin-Pt1a protein, from Spider, contains 77 amino acids, is soluble, locates in Extracellular.

Excitatory toxin that acts on both calcium and sodium (Nav) channels, It preferentially blocks a subset of calcium channels that is apparently not required for neurotransmitter release, it decreases threshold for sodium channel activation and it slows sodium channel inactivation, As it enhances synaptic transmission by prolonging presynaptic release of neurotransmitter, its effects on sodium and calcium channels may act synergistically to sustain the terminal excitability

Belongs to the neurotoxin 02 (plectoxin) family, 01 (Tx3) subfamily


This is Mu-theraphotoxin-Phlo1a protein, from Tarantula spider, contains 89 amino acids, is soluble, locates in Extracellular.

Gating-modifier toxin that inhibits voltage-gated sodium channel Nav by shifting the threshold for channel activation to more positive potentials, This toxin moderately inhibits human Nav1,7/SCN9A (IC(50)=459 nM) and weakly inhibits hNav1,2/SCN2A and hNav1,5/SCN5A (<20% inhibition at 1 uM peptide), Inhibition of Nav1,7 is voltage-dependent, with lower inhibition at more positive test pulses

Belongs to the neurotoxin 10 (Hwtx-1) family, 39 (Jztx-34) subfamily


This is Mu-theraphotoxin-Phlo1b protein, from Tarantula spider, contains 90 amino acids, is soluble, locates in Extracellular.

Gating-modifier toxin that inhibits voltage-gated sodium channel Nav by shifting the threshold for channel activation to more positive potentials, This toxin moderately inhibits human Nav1,7/SCN9A (IC(50)=360 nM) and weakly inhibits hNav1,2/SCN2A (37% inhibition at 1 uM peptide) and hNav1,5/SCN5A (<20% inhibition at 1 uM peptide), Inhibition of Nav1,7 is voltage-dependent, with lower inhibition at more positive test pulses


This is Phospholipase A2 homolog EPL_00195 protein, from Leakey's carpet viper, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 homolog that lacks enzymatic activity (By similarity), Shows high myotoxin activities and displays edema-inducing activities (By similarity), Has cytotoxic activities against HUVEC cells (LC(50)=2,5 uL) and human lung adenocarcinoma A549 cells (LC(50)=2,9 uL)

Belongs to the phospholipase A2 family, Group II subfamily, S49 sub-subfamily


This is Phospholipase A2 homolog ECS_00014 protein, from Saw-scaled viper, contains 122 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 homolog that lacks enzymatic activity (By similarity), Shows high myotoxin activities and displays edema-inducing activities (By similarity), Has cytotoxic activities against HUVEC cells (LC(50)=12,2 uL) and human lung adenocarcinoma A549 cells (LC(50)=8,5 uL)


This is Phospholipase A2 homolog ECO_00035 protein, from Carpet viper, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 homolog that lacks enzymatic activity (By similarity), Shows high myotoxin activities and displays edema-inducing activities (By similarity), Has cytotoxic activities against HUVEC cells (LC(50)=4,9 uL) and human lung adenocarcinoma A549 cells (LC(50)=3,5 uL) (PubMed:23747272)


This is Glucoamylase ARB_02327-1 protein, from Trichophyton mentagrophytes, contains 610 amino acids, is soluble, locates in Extracellular.

Belongs to the glycosyl hydrolase 15 family


This is Choriogonadotropin subunit beta 7 protein, from Human, contains 165 amino acids, is soluble, locates in Extracellular.

Beta subunit of the human chorionic gonadotropin (hCG), hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated, The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH), The beta subunits are distinct in each of the hormones and confer receptor and biological specificity, Has an essential role for pregnancy and maternal adaptation, Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Belongs to the glycoprotein hormones subunit beta family


This is Protein PET122, mitochondrial protein, from Baker's yeast, contains 254 amino acids, is membrane-bound, locates in Mitochondrion.

Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3), PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA


This is Ribulose bisphosphate carboxylase small subunit 1B, chloroplastic protein, from Mouse-ear cress, contains 181 amino acids, is membrane-bound, locates in Plastid.

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate, Both reactions occur simultaneously and in competition at the same active site, Although the small subunit is not catalytic it is essential for maximal activity

Belongs to the RuBisCO small chain family


This is Protein PET54 protein, from Baker's yeast, contains 293 amino acids, is membrane-bound, locates in Mitochondrion.

Activator of specific mitochondrial mRNAs, PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3


This is 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial protein, from Bovine, contains 455 amino acids, is soluble, locates in Mitochondrion.

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2), It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)


This is Female-specific protein transformer protein, from Fruit fly, contains 197 amino acids, locates in Nucleus.

Member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl, Activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins, Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site, No known function in males


This is ATP synthase gamma chain, chloroplastic protein, from Chlamydomonas smithii, contains 358 amino acids, is membrane-bound, locates in Plastid.

Produces ATP from ADP in the presence of a proton gradient across the membrane, The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex

Belongs to the ATPase gamma chain family


This is Transposable element Hobo transposase protein, from Fruit fly, contains 644 amino acids, has 1 BED-type Zinc finger, locates in Nucleus.

BED-type


This is Small ribosomal subunit protein mS44 protein, from Baker's yeast, contains 339 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the mitochondrion-specific ribosomal protein mS44 family


This is Large ribosomal subunit protein bL27m protein, from Baker's yeast, contains 371 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bL27 family


This is SPARC protein, from Bovine, contains 303 amino acids, is soluble, locates in Extracellular.

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines, Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes, There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity


This is Large ribosomal subunit protein mL60 protein, from Baker's yeast, contains 131 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL60 family


This is Cytochrome b translational activator protein CBS1, mitochondrial protein, from Baker's yeast, contains 229 amino acids, is membrane-bound, locates in Mitochondrion.

mRNA-specific translational activator of cytochrome b, The cytochrome b (COB) leader RNA may represent the target sequence for CBS1 and CBS2, tethering the COB mRNA to the inner mitochondrial membrane, where cotranslational insertion of cytochrome b into the membrane can occur


This is Cecropin-P1 protein, from Pig roundworm, contains 70 amino acids, is soluble, locates in Extracellular.

Has antibacterial activity against several Gram-positive and Gram-negative bacteria, Is weakly active against yeasts, Acts by a nonpore mechanism


This is Rubber elongation factor protein protein, from Para rubber tree, contains 138 amino acids, is soluble, locates in Cytoplasm.

May be part of the rubber biosynthesis machinery, Plays a role in rubber elongation


This is Protein B4 protein, from African clawed frog, contains 273 amino acids, locates in Nucleus.


This is Serendipity locus protein H-1 protein, from Fruit fly, contains 869 amino acids, has 8 C2H2-type Zinc finger, locates in Nucleus.

May belong to a complex set of multifingered proteins which play an important role in gene activation or regulation at early embryonic stages through a maximal accumulation of their transcripts (or protein product) in the mature oocyte


This is Zinc finger protein 37A protein, from Human, contains 561 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 10 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

May be involved in transcriptional regulation

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Proliferating cell nuclear antigen protein, from African clawed frog, contains 261 amino acids, locates in Nucleus.

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand, Promotes 3'-5' nuclease activity of the DNA-endonuclease apex2,L in response to DNA damage (PubMed:28028224, PubMed:29361157)


This is Toxin C13S1C1 protein, from Eastern green mamba, contains 80 amino acids, is soluble, locates in Extracellular.

Is cytotoxic against human non-small cell lung adenocarcinoma A-549 cells (LC(50)=56 ug/ml), breast adenocarcinoma MDA-MBsy-231 cells (LC(50)=62 ug/ml) and colorectal adenocarcinoma HT-29 cells (LC(50)=110 ug/ml), Shows low hemolytic activity against human erythrocytes (LC(50)>600 ug/ml), Is also cytotoxic against human umbilical vein endothelial HUVEC cells (57 ug/ml) indicating no differential activity against cell lines derived from neoplastic tissues

Belongs to the snake three-finger toxin family, Short-chain subfamily, Orphan group X sub-subfamily


This is Delta-conotoxin TxVIA protein, from Cloth-of-gold cone, contains 78 amino acids, is soluble, locates in Extracellular.

Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process, Binding of this toxin is strongly calcium-dependent but not voltage-dependent, The binding site is most likely on the extracellular side of the sodium channel, Binds receptor sites on both mollusk and rat central nervous system, but despite its high affinity binding to rat sodium channel, it has no functional effect in vivo and in vitro on it, Has also no effect on Gambusia fish, Is important in mollusk for the paralysis of the prey, Upon injection of the peptide, a subordinate lobster assumes an exaggerated dominant posture (of a 'King-Kong' lobster!)


This is Interferon-induced GTP-binding protein Mx2 protein, from Rat, contains 659 amino acids, is soluble, locates in Cytoplasm.

Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Flocculation suppression protein protein, from Baker's yeast, contains 766 amino acids, locates in Nucleus.

Involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation), Mutations in SFL1 causes constitutive cell aggregation

In the N-terminal section; belongs to the HSF family


This is Protein MAK11 protein, from Baker's yeast, contains 414 amino acids, is membrane-bound, locates in Nucleus.

Essential for cell growth, Plays a role in assembly of 60S pre-ribosomal particles in the nucleolus, Also required for replication of the M1 double-stranded RNA of the L-A virus, This latter function may reflect an enhanced requirement for free 60S ribosomal particles for the translation of viral mRNAs which lack poly-A tails


This is Zinc finger protein 10 protein, from Human, contains 573 amino acids, has 1 C2H2-type 1; atypical Zinc finger, has 9 C2H2-type Zinc finger, has 1 C2H2-type 11; atypical Zinc finger, locates in Nucleus.

C2H2-type 1; atypical

C2H2-type 11; atypical


This is Inosine-5'-monophosphate dehydrogenase protein, from Leishmania donovani, contains 514 amino acids, locates in Peroxisome.

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth


This is Protein ATP12, mitochondrial protein, from Baker's yeast, contains 325 amino acids, locates in Mitochondrion.

Essential for the assembly of the mitochondrial F1-F0 complex


This is Large ribosomal subunit protein bL17m protein, from Baker's yeast, contains 238 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bL17 family


This is Large ribosomal subunit protein mL58 protein, from Baker's yeast, contains 195 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL58 family


This is P34 probable thiol protease protein, from Soybean, contains 379 amino acids, locates in Lysosome/Vacuole.


This is Probable oxidoreductase AIM17 protein, from Baker's yeast, contains 465 amino acids, locates in Mitochondrion.


This is Protein SCO1, mitochondrial protein, from Baker's yeast, contains 295 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex, Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX


This is Large ribosomal subunit protein eL24B protein, from Baker's yeast, contains 155 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL24 family


This is Elongation factor G, mitochondrial protein, from Baker's yeast, contains 761 amino acids, locates in Mitochondrion.

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation, During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively, Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily


This is rRNA methyltransferase 1, mitochondrial protein, from Baker's yeast, contains 412 amino acids, locates in Mitochondrion.

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 2270 (Gm2270) in the 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA, This modification seems to be important for the normal accumulation of the mitochondrial large ribosomal subunit

Belongs to the class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase TrmH family


This is Large ribosomal subunit protein bL32m protein, from Baker's yeast, contains 183 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the bacterial ribosomal protein bL32 family


This is Catabolic L-serine/threonine dehydratase protein, from Baker's yeast, contains 360 amino acids, locates in Mitochondrion.

Belongs to the serine/threonine dehydratase family


This is CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase protein, from Baker's yeast, contains 521 amino acids, locates in Mitochondrion.

Essential for the viability of mitochondrial petite mutant, Catalyzes the committed step to the synthesis of the acidic phospholipids

Belongs to the CDP-alcohol phosphatidyltransferase class-II family


This is Pantothenate transporter FEN2 protein, from Baker's yeast, contains 512 amino acids, is membrane-bound, locates in Cell membrane.

Transports pantothenate into the cell, Also involved in the catabolite repression-mediated regulation of ergosterol biosynthesis and in fenpropimorph resistance

Belongs to the major facilitator superfamily, Allantoate permease family


This is Chromatin structure-remodeling complex protein RSC6 protein, from Baker's yeast, contains 483 amino acids, locates in Nucleus.

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants


This is Beta-enolase protein, from Rabbit, contains 434 amino acids, is soluble, locates in Cytoplasm.

Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate, Appears to have a function in striated muscle development and regeneration


This is Aquaporin TIP3-1 protein, from Mouse-ear cress, contains 268 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Water channel required to facilitate the transport of water from the vacuolar compartment to the cytoplasm

Belongs to the MIP/aquaporin (TC 1,A,8) family, TIP (TC 1,A,8,10) subfamily


This is DNA polymerase epsilon subunit C protein, from Baker's yeast, contains 201 amino acids, locates in Nucleus.

As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication, It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork, It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication, It is also involved in DNA synthesis during DNA repair


This is Isocitrate lyase protein, from Mouse-ear cress, contains 576 amino acids, locates in Peroxisome.

Involved in storage lipid mobilization during the growth of higher plant seedling

Belongs to the isocitrate lyase/PEP mutase superfamily, Isocitrate lyase family


This is Isocitrate lyase protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 548 amino acids, locates in Peroxisome.

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle, Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available, Acts also on 2-methylisocitrate


This is Small ribosomal subunit protein bS1c protein, from Spinach, contains 411 amino acids, locates in Plastid.

Component of the chloroplast ribosome (chloro-ribosome), a dedicated translation machinery responsible for the synthesis of chloroplast genome-encoded proteins, including proteins of the transcription and translation machinery and components of the photosynthetic apparatus (PubMed:10874039, PubMed:28007896), Actively engaged in the initiation complex formation via a strong mRNA-binding activity, Possesses a poly(A)-binding activity which might play a role as a control element in chloroplast mRNA translation (PubMed:1527032)

Belongs to the bacterial ribosomal protein bS1 family


This is Delta-ctenitoxin-Pn2a protein, from Brazilian armed spider, contains 82 amino acids, is soluble, locates in Extracellular.

Toxin that is known to potentiate erectile function (PubMed:18397797), It binds voltage-dependently to sodium channels (Nav), inhibits the inactivation of the activated channels and decreases the peak inward current (PubMed:19231838, PubMed:26119670), The toxin delays inactivation of Nav1,2/SCN2A, Nav1,3/SCN3A, Nav1,4/SCN4A and Nav1,8/SCN10A, slows the inactivation process and decreases the sodium peak amplitude of Nav1,5/SCN5A and Nav1,6/SCN8A (PubMed:26119670), In vivo, it enhances erectile function by inducing the release of nictric oxide (NO): it slows the sodium current, leading to depolarization, which leads to an increase in calcium influx (probably via activation of N-type calcium channels) which in turn activates neuronal NO synthase (nNOS/NOS1), inducing nitric oxide (NO) production (PubMed:20722794, PubMed:21975567), In a final step, NO activates soluble guanylate cyclase (GUCY1A1/GUCY1B1) which in turn increases cGMP formation, resulting in penile erection (PubMed:23583324), It is noteworthy that the toxin does not provoke erection by inhibiting phosphodiesterase type 5 (PDE5A), an enzyme that hydrolysis cGMP (PubMed:23583324), In vivo, it also causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 0,79 mg/mouse (PubMed:1397265, PubMed:16278100), It is insecticidal to the larval and adult forms of the house fly (PubMed:1397265), The toxin also improves cavernosal relaxation in different models where erectile dysfonction is observed, such as deoxycorticosterone-acetate (DOCA)-salt hypertensive rats, mice models for type-1 diabetes, as well as elderly rats (PubMed:18397797, PubMed:21975567, PubMed:22925420)

Belongs to the neurotoxin 03 (Tx2) family, 06 subfamily


This is Meiosis-specific protein MEI4 protein, from Baker's yeast, contains 408 amino acids, locates in Nucleus.

Required for meiotic induction of recombination, viable spore production and chromosome synapsis, Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation


This is Cellular retinoic acid-binding protein 1 protein, from Human, contains 137 amino acids, is soluble, locates in Cytoplasm.

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors

Belongs to the calycin superfamily, Fatty-acid binding protein (FABP) family


This is Cyclin-B1-1 protein, from Mouse-ear cress, contains 428 amino acids, locates in Nucleus.

Belongs to the cyclin family, Cyclin AB subfamily


This is Myo-inositol transporter 2 protein, from Baker's yeast, contains 609 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family


This is Protein linkin protein, from Caenorhabditis elegans, contains 599 amino acids, is membrane-bound, locates in Cell membrane.

Probable cell adhesion protein involved in gonadal cell migration


This is 5-hydroxytryptamine receptor 1F protein, from Rat, contains 366 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling inhibits adenylate cyclase activity

Belongs to the G-protein coupled receptor 1 family


This is Large ribosomal subunit protein uL3m protein, from Baker's yeast, contains 269 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL3 family


This is Transthyretin protein, from American bullfrog, contains 153 amino acids, is soluble, locates in Extracellular.

Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4), Probably transports triiodothyronine from the bloodstream to the brain


This is Glycerol-3-phosphate dehydrogenase, mitochondrial protein, from Baker's yeast, contains 649 amino acids, is membrane-bound, locates in Mitochondrion.

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family


This is Heme-binding protein HMX1 protein, from Baker's yeast, contains 317 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays an important role in the degradation of heme under conditions of iron deprivation


This is Vacuolar ATPase assembly integral membrane protein VPH2 protein, from Baker's yeast, contains 215 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Small ribosomal subunit protein mS38 protein, from Baker's yeast, contains 111 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081), mS38 is also involved in the splicing of the COX1 mRNA (PubMed:16339141)

Belongs to the mitochondrion-specific ribosomal protein mS38 family


This is Large ribosomal subunit protein uL23m protein, from Baker's yeast, contains 263 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uL23 family


This is Biotin synthase, mitochondrial protein, from Baker's yeast, contains 375 amino acids, locates in Mitochondrion.

Belongs to the radical SAM superfamily, Biotin synthase family


This is Diphthine methyl ester synthase protein, from Baker's yeast, contains 300 amino acids, is soluble, locates in Cytoplasm.

S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester, The four successive methylation reactions represent the second step of diphthamide biosynthesis

Belongs to the diphthine synthase family


This is Meiosis protein 5 protein, from Baker's yeast, contains 222 amino acids, locates in Nucleus.

Involved in meiotic DNA-break repair, Required for the recruitment of DCM1 to meiosis recombination hot spots


This is tRNA modification GTPase MSS1, mitochondrial protein, from Baker's yeast, contains 526 amino acids, locates in Mitochondrion.

GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs, Involved in the expression of cytochrome c oxidase subunit 1 (COX1), Works in association with the small subunit of mitoribosomes

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, TrmE GTPase family


This is TRAPP-associated protein TCA17 protein, from Baker's yeast, contains 152 amino acids, locates in Golgi apparatus.

Required, together with the TRAPP II subunit TRS33, for TRAPP II complex assembly or stability, and for proper Golgi localization of TRAPP and the Rab GTPase YPT31

Belongs to the TRAPP small subunits family, Sedlin subfamily


This is Chromatin-remodeling complex subunit IES6 protein, from Baker's yeast, contains 166 amino acids, locates in Nucleus.

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex, Also involved in the regulation of telomere length


This is Methionyl-tRNA formyltransferase, mitochondrial protein, from Baker's yeast, contains 401 amino acids, locates in Mitochondrion.

Formylates methionyl-tRNA in mitochondria and the cytoplasm (PubMed:10781559, PubMed:30409808), Responsible for the formylation of the 8 N-terminally formylated (Nt-formylated) mitochondrial matrix proteins that are encoded by mitochondrial DNA (PubMed:10781559, PubMed:12549912), Nt-formylated proteins in the cytoplasm are strongly up-regulated in stationary phase or upon starvation for specific amino acids (His or Lys) and are targeted for degradation by a PSH1 E3 ubiquitin ligase-mediated fMet/N-end rule pathway, Increased Nt-formylation of cytosolic proteins appears to be important for adaptation to these stresses, Stationary phase-degraded Nt-formylated proteins include histone H3-like centromeric protein CSE4, Mediator complex subunit 3 (PGD1) and small ribosomal subunit protein uS8-A (RPS22A) (PubMed:30409808)


This is Mitochondrial genome maintenance protein MGM101 protein, from Baker's yeast, contains 269 amino acids, is soluble, locates in Mitochondrion.

Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome, Binds to DNA


This is Meiotic recombination protein REC114 protein, from Baker's yeast, contains 428 amino acids, locates in Nucleus.

Required for the production of double-strand breaks (DSBs) in meiotic recombination initiation; not required for mitosis, Plays a role in activation of the DSB nuclease SPO11 at recombination hotspots, Prevents accumulation of meiotic double strand break intermediates and is needed for the proper timing of the first meiotic division, Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation


This is Mitochondrial escape protein 2 protein, from Baker's yeast, contains 850 amino acids, is membrane-bound, locates in Mitochondrion.

Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape, Involved in the regulation of mtDNA nucleotide structure and number, May have a dispensable role in early maturation of pre-rRNA


This is Lipoyl synthase, mitochondrial protein, from Baker's yeast, contains 414 amino acids, locates in Mitochondrion.

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives

Belongs to the radical SAM superfamily, Lipoyl synthase family


This is Large ribosomal subunit protein uL6m protein, from Baker's yeast, contains 214 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL6 family


This is Protein SMY2 protein, from Baker's yeast, contains 740 amino acids, is soluble, locates in Cytoplasm.


This is Arginase protein, from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), contains 358 amino acids, is soluble, locates in Cytoplasm.


This is ATP-dependent permease MDL2, mitochondrial protein, from Baker's yeast, contains 773 amino acids, is membrane-bound, locates in Mitochondrion.

Belongs to the ABC transporter superfamily, ABCB family, Mitochondrial peptide exporter (TC 3,A,1,212) subfamily


This is Protein SOF1 protein, from Baker's yeast, contains 489 amino acids, locates in Nucleus.

Belongs to the WD repeat DCAF13/WDSOF1 family


This is Small ribosomal subunit protein uS5m protein, from Baker's yeast, contains 307 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uS5 family


This is Deoxyribonuclease Tat-D protein, from Baker's yeast, contains 418 amino acids, is soluble, locates in Cytoplasm.

Has both endo- and exonuclease activities, Incises double-stranded DNA without obvious specificity via its endonuclease activity and excises the DNA from the 3'-to 5'-end by its exonuclease activity, May have a role in apoptosis

Belongs to the metallo-dependent hydrolases superfamily, TatD-type hydrolase family


This is Protein CASP protein, from Baker's yeast, contains 679 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in intra-Golgi transport


This is Zinc-regulated transporter 3 protein, from Baker's yeast, contains 503 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Transports zinc from storage in the vacuole to the cytoplasm

Belongs to the ZIP transporter (TC 2,A,5) family


This is Ran GTPase-activating protein 2 protein, from Caenorhabditis elegans, contains 960 amino acids, locates in Nucleus.

GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking, Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state, Required for correct chromosome alignment and segregation on the metaphase plate


This is Protein lin-36 protein, from Caenorhabditis elegans, contains 962 amino acids, has 1 THAP-type Zinc finger, locates in Nucleus.

THAP-type

Required to negatively regulate vulval development, Antagonizes Ras-mediated vulval induction, Acts cell autonomously


This is Metalloproteinase inhibitor 1 protein, from Pig, contains 207 amino acids, is soluble, locates in Extracellular.

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor, Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16, Does not act on MMP14, Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1, Plays a role in integrin signaling (By similarity)

Belongs to the protease inhibitor I35 (TIMP) family


This is Protein SFK1 protein, from Baker's yeast, contains 353 amino acids, is membrane-bound, locates in Cell membrane.

May control the production of phosphatidylinositol 4-phosphate (PI4P) by the STT4 PI 4-kinase, Mediates proper localization of STT4 to the plasma membrane


This is Large ribosomal subunit protein uL14m protein, from Baker's yeast, contains 138 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the universal ribosomal protein uL14 family


This is Probable folylpolyglutamate synthase protein, from Baker's yeast, contains 430 amino acids, locates in Mitochondrion.

Conversion of folates to polyglutamate derivatives

Belongs to the folylpolyglutamate synthase family


This is Probable serine/threonine-protein kinase KKQ8 protein, from Baker's yeast, contains 724 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NPR/HAL subfamily, HAL5 sub-subfamily


This is RNA annealing protein YRA2 protein, from Baker's yeast, contains 203 amino acids, locates in Nucleus.

Involved in export of poly(A) mRNAs from the nucleus, Recruited to the coding sequences as well as poly-A sites of active genes


This is Proteasome assembly chaperone 2 protein, from Baker's yeast, contains 267 amino acids, is soluble, locates in Cytoplasm.

Involved in 20S proteasome assembly, Required for maximal proteasome activity, Affects the chymotrypsin-like activity of the proteasome, Can be degraded by the proteasome, Involved in the endoplasmic reticulum-associated degradation (ERAD)


This is Transcription elongation factor 1 protein, from Baker's yeast, contains 145 amino acids, locates in Nucleus.

Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions


This is Probable S-adenosyl-L-methionine-dependent RNA methyltransferase RSM22, mitochondrial protein, from Baker's yeast, contains 628 amino acids, locates in Mitochondrion.

Probable S-adenosyl-L-methionine-dependent RNA methyltransferase (PubMed:19351663, PubMed:24651469), May provide the activity for methylation of the rRNA of the small mitochondrial subunit, which is required for the assembly and stability of the mitochondrial ribosome (PubMed:22689777), Has no protein methyltransferase activity (PubMed:24651469)

Belongs to the methyltransferase superfamily, Rsm22 family


This is ATP-dependent (S)-NAD(P)H-hydrate dehydratase protein, from Baker's yeast, contains 337 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP, Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration


This is COX assembly mitochondrial protein protein, from Baker's yeast, contains 111 amino acids, is membrane-bound, locates in Mitochondrion.

Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration, Binds copper, May be involved in copper trafficking and distribution to mitochondrial COX and SOD1


This is Protein PRY2 protein, from Baker's yeast, contains 329 amino acids, is soluble, locates in Extracellular.

Secreted protein required for efficient export of lipids such as acetylated sterols, Acts in detoxification of hydrophobic compounds


This is ATP-dependent RNA helicase DBP7 protein, from Baker's yeast, contains 742 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5,8S rRNAs

Belongs to the DEAD box helicase family, DDX31/DBP7 subfamily


This is DNA-directed RNA polymerase III subunit RPC5 protein, from Baker's yeast, contains 282 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs, The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation


This is Ribosome biogenesis protein UTP30 protein, from Baker's yeast, contains 274 amino acids, locates in Nucleus.

Involved in rRNA-processing and ribosome biosynthesis

Belongs to the universal ribosomal protein uL1 family, Highly divergent


This is Golgi apparatus membrane protein TVP38 protein, from Baker's yeast, contains 337 amino acids, is membrane-bound, locates in Golgi apparatus.

Golgi membrane protein involved in vesicular trafficking and spindle migration


This is Protein SRL3 protein, from Baker's yeast, contains 246 amino acids, is soluble, locates in Cytoplasm.

Weakly suppresses a RAD53 null mutation when overexpressed


This is Defensin protein, from Fruit fly, contains 92 amino acids, is soluble, locates in Extracellular.

Responsible for the anti Gram-positive activity of immune hemolymph, Expressed in the absence of immune challenge during metamorphosis

Belongs to the invertebrate defensin family, Type 1 subfamily


This is Large ribosomal subunit protein mL44 protein, from Baker's yeast, contains 390 amino acids, locates in Mitochondrion.

Belongs to the ribonuclease III family, Mitochondrion-specific ribosomal protein mL44 subfamily


This is Large ribosomal subunit protein uL5m protein, from Baker's yeast, contains 292 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL5 family


This is Large ribosomal subunit protein uL15m protein, from Baker's yeast, contains 322 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL15 family


This is Large ribosomal subunit protein uL10m protein, from Baker's yeast, contains 249 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL10 family


This is Large ribosomal subunit protein mL57 protein, from Baker's yeast, contains 253 amino acids, locates in Mitochondrion.

Belongs to the ribonuclease III family, Mitochondrion-specific ribosomal protein mL57 subfamily


This is Large ribosomal subunit protein bL28m protein, from Baker's yeast, contains 258 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bL28 family


This is Large ribosomal subunit protein mL41 protein, from Baker's yeast, contains 146 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL41 family


This is Large ribosomal subunit protein mL40 protein, from Baker's yeast, contains 147 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL40 family


This is Large ribosomal subunit protein mL46 protein, from Baker's yeast, contains 281 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL46 family


This is Large ribosomal subunit protein mL54 protein, from Baker's yeast, contains 105 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:24675956, PubMed:25609543), mL54 may have a meiosis-specific role as it accumulates during the middle stage of sporulation (PubMed:15543521)

Belongs to the mitochondrion-specific ribosomal protein mL54 family


This is DNA repair protein rad26 protein, from Fission yeast, contains 614 amino acids, locates in Nucleus.

Involved in cell cycle arrest when DNA synthesis is inhibited by hydroxyurea, and in mitosis arrest after treatment with DNA-damaging agents, This protein is S phase-specific


This is 6-phosphogluconolactonase-like protein 2 protein, from Baker's yeast, contains 315 amino acids, is soluble, locates in Cytoplasm.

May be involved in regulation of tRNA subcellular distribution

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily


This is B3 domain-containing protein VP1 protein, from Rice, contains 727 amino acids, locates in Nucleus.

Probable transcription factor that may participate in abscisic acid-regulated gene expression during seed development, May be required for seed maturation and dormancy induction


This is Mitochondrial intermembrane space cysteine motif-containing protein MIX23 protein, from Baker's yeast, contains 196 amino acids, is soluble, locates in Mitochondrion.

Regulator of the mitochondrial protein import machinery that is localized in the mitochondrial intermembrane space (IMS) and facilitates the transport of proteins from the cytosol into the mitochondrial matrix (PubMed:32826315), Not essential for mitochondrial protein import but induced and required when mitochondrial import is compromised (PubMed:32826315), Stimulates or stabilizes the translocation into the mitochondria of proteins such as OXA1, ATP1 and COX12 (PubMed:32826315)


This is Serine/threonine-protein phosphatase 4 regulatory subunit 2 protein, from Baker's yeast, contains 441 amino acids, locates in Nucleus.

Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process, Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint


This is Obg-like ATPase 1 protein, from Baker's yeast, contains 394 amino acids, is soluble, locates in Cytoplasm.

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency, Has lower affinity for GTP

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, YchF/OLA1 subfamily


This is Ribosomal lysine N-methyltransferase 3 protein, from Baker's yeast, contains 552 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-40'

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Quinidine resistance protein 3 protein, from Baker's yeast, contains 689 amino acids, is membrane-bound, locates in Cell membrane.

Multidrug resistance transporter involved in resistance and adaptation to quinidine and to the herbicide barban (4-chloro-2-butynyl [3-chlorophenyl] carbamate)

Belongs to the major facilitator superfamily, CAR1 family


This is Pre-mRNA-splicing factor SLT11 protein, from Baker's yeast, contains 364 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing, Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, Binds to RNA


This is Probable tubulin--tyrosine ligase PBY1 protein, from Baker's yeast, contains 753 amino acids, is soluble, locates in Cytoplasm.

Probable P-body-associated tubulin--tyrosine ligase

Belongs to the tubulin--tyrosine ligase family


This is Hsp70 nucleotide exchange factor FES1 protein, from Baker's yeast, contains 290 amino acids, is soluble, locates in Cytoplasm.

Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance, Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1, Required for fully efficient Hsp70-mediated folding of proteins


This is 25S rRNA (adenine(2142)-N(1))-methyltransferase protein, from Baker's yeast, contains 337 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA, N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit


This is Pre-mRNA-splicing factor SPP381 protein, from Baker's yeast, contains 291 amino acids, locates in Nucleus.

Component of the spliceosome and rRNA processing machinery, In association with the spliceosomal U4/U6,U5 tri-snRNP particle, required for splicing of pre-mRNA


This is Inner membrane mitoribosome receptor MBA1, mitochondrial protein, from Baker's yeast, contains 278 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial inner membrane-associated mitoribosome receptor that spatially aligns the mitoribosome exit tunnel with the membrane insertion machinery and allows cotranslational protein membrane insertion


This is Pre-mRNA-splicing factor NTC20 protein, from Baker's yeast, contains 140 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing, As a component of the NTC complex, associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation


This is SWR1-complex protein 5 protein, from Baker's yeast, contains 303 amino acids, locates in Nucleus.

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling, Involved in chromosome stability


This is UBX domain-containing protein 7 protein, from Baker's yeast, contains 436 amino acids, locates in Endoplasmic reticulum.

Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway


This is Protein YGP1 protein, from Baker's yeast, contains 354 amino acids, is soluble, locates in Extracellular.

May be involved in cellular adaptations prior to stationary phase

To yeast sporulation-specific protein SPS100


This is ADP-ribosylation factor GTPase-activating protein GLO3 protein, from Baker's yeast, contains 493 amino acids, has 1 C4-type Zinc finger, locates in Golgi apparatus.

GTPase-activating protein for the ADP ribosylation factor (ARF) family, Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum


This is Serine--tRNA ligase, mitochondrial protein, from Baker's yeast, contains 446 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the attachment of serine to tRNA(Ser) (By similarity)

Belongs to the class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily


This is DUP240 protein DFP4 protein, from Baker's yeast, contains 235 amino acids, is membrane-bound, locates in Cell membrane.


This is Suppressor of HU sensitivity involved in recombination protein 1 protein, from Baker's yeast, contains 150 amino acids, locates in Nucleus.

Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase