This is Uncharacterized protein C902.06 protein, from Fission yeast, contains 397 amino acids, is soluble, locates in Cytoplasm.


This is Spindle pole body component alp6 protein, from Fission yeast, contains 832 amino acids, is soluble, locates in Cytoplasm.

Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles


This is NASP-related protein sim3 protein, from Fission yeast, contains 396 amino acids, locates in Nucleus.

Histone H3 and H3-like CENP-A-specific chaperone, Promotes delivery and incorporation of CENP-A in centromeric chromatin, probably by escorting nascent CENP-A to CENP-A chromatin assembly factors, Required for central core silencing and normal chromosome segregation


This is Inner kinetochore subunit cnp3 protein, from Fission yeast, contains 643 amino acids, is soluble, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly


This is E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 protein, from Fission yeast, contains 205 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains, Involved in maintaining genome stability where it acts in the cellular response to DNA damage


This is Rpb7-binding protein seb1 protein, from Fission yeast, contains 620 amino acids, locates in Nucleus.

Involved in the processing of pol II transcripts


This is tRNA-dihydrouridine(47) synthase [NAD(P)(+)] protein, from Fission yeast, contains 617 amino acids, has 1 C3H1-type Zinc finger, locates in Nucleus.

Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs and mRNAs (PubMed:34798057), Modifies the uridine in position 47 (U47) in the D-loop of tRNAs (PubMed:34798057), Also able to mediate formation of dihydrouridine outside of the D-loop of tRNAs (PubMed:34798057), Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (PubMed:34798057), Dus3-mediated dihydrouridylation of the mRNA encoding alpha-tubulin nda2 is required for meiotic chromosome segregation (PubMed:34798057)

Belongs to the Dus family, Dus3 subfamily


This is DSC E3 ubiquitin ligase complex subunit 2 protein, from Fission yeast, contains 372 amino acids, is membrane-bound, locates in Golgi apparatus.

Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions, The complex also plays an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation


This is Poly(A) RNA polymerase cid14 protein, from Fission yeast, contains 684 amino acids, locates in Nucleus.

Required for 3' polyadenylation of the 5,8S and 25S rRNAs as a prelude to their degradation in the exosome, Involved in the nucleolar organization to ensure faithful chromosome segregation during mitosis

Belongs to the DNA polymerase type-B-like family


This is NURS complex subunit red1 protein, from Fission yeast, contains 712 amino acids, has 1 C3H1-type Zinc finger, locates in Nucleus.

Promotes the exosome-mediated degradation of mRNAs containing a DSR (determinant of selective removal) signal sequence from mitotic cells


This is Ubiquitin carboxyl-terminal hydrolase 2 protein, from Fission yeast, contains 300 amino acids, locates in Nucleus.

Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins, This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin


This is Small nuclear ribonucleoprotein Sm D3 protein, from Fission yeast, contains 97 amino acids, locates in Nucleus.

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity)

Belongs to the snRNP core protein family


This is Actin-related protein 2 protein, from Fission yeast, contains 390 amino acids, is soluble, locates in Cytoplasm.

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks, Seems to contact the pointed end of the daughter actin filament (By similarity), During cytokinesis it colocalizes to the cortical actin patches until spetation is complete, Has a role in the mobility of these patches, Essential for viability

Belongs to the actin family, ARP2 subfamily


This is Mating-type switching protein swi1 protein, from Fission yeast, contains 971 amino acids, locates in Nucleus.

Forms a fork protection complex (FPC) with swi3, FPC coordinates leading and lagging strand synthesis and moves with the replication fork, It is required for programmed fork-pausing which is necessary for mating-type switching, FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors, It is involved in termination at the mat1-proximal polar-terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1


This is Fas-associated death domain protein protein, from Fruit fly, contains 239 amino acids, is soluble, locates in Cytoplasm.

Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria, Interacts with Dredd, promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis


This is Chitinase-like protein Idgf2 protein, from Fruit fly, contains 440 amino acids, is soluble, locates in Extracellular.

Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells, May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex

Belongs to the glycosyl hydrolase 18 family, IDGF subfamily


This is Dual specificity tyrosine-phosphorylation-regulated kinase 2 protein, from Fruit fly, contains 722 amino acids, is soluble, locates in Cytoplasm.

In vitro; can phosphorylate exogenous substrates on Ser and Thr residues, May have a physiological role in development being involved in cellular growth and differentiation

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily


This is RuvB-like helicase 2 protein, from Fruit fly, contains 481 amino acids, locates in Nucleus.

Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is Peroxiredoxin 1 protein, from Fruit fly, contains 194 amino acids, is soluble, locates in Cytoplasm.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events, Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity), Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)

Belongs to the peroxiredoxin family, AhpC/Prx1 subfamily


This is Phenoloxidase 2 protein, from Fruit fly, contains 684 amino acids, is soluble, locates in Extracellular.

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds, Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinonee (By similarity)


This is Longitudinals lacking protein, isoforms N/O/W/X/Y protein, from Fruit fly, contains 878 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is Kinesin-like protein subito protein, from Fruit fly, contains 628 amino acids, is soluble, locates in Cytoplasm.

Required during female meiosis for bipolar spindle formation in the absence of the centrosomes and chromosome homolog segregation, Also has roles in male meiosis and mitotic divisions of the early embryo

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family


This is Neutral ceramidase protein, from Fruit fly, contains 704 amino acids, is soluble, locates in Extracellular.

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6,5-7,5, Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface, Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition

Belongs to the neutral ceramidase family


This is Protein takeout protein, from Fruit fly, contains 249 amino acids, is soluble, locates in Extracellular.

Participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities, Involved in male courtship behavior, In the brain-associated fat body, transcription is enhanced by the dsx and fru male-specific isoforms and repressed by the dsx female-specific isoform


This is Protein distal antenna protein, from Fruit fly, contains 678 amino acids, locates in Nucleus.

Probable transcription factor with a role in the retinal determination (RD) network, Regulates ato expression and is required for normal R8 induction and differentiation, Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF), Dan and Danr lie downstream of so and require dac function for highest levels of expression, Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures


This is Protein vreteno protein, from Fruit fly, contains 691 amino acids, is soluble, locates in Cytoplasm.

Gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for the germline integrity, Acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis, Required for primary piRNA biogenesis in both germline and somatic gonadal tissues


This is Bursicon protein, from Fruit fly, contains 173 amino acids, is soluble, locates in Extracellular.

Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading, Heterodimer specifically activates the G protein-coupled receptor rk


This is 3'-5' exonuclease protein, from Fruit fly, contains 353 amino acids, locates in Nucleus.

Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction (PubMed:18346216, PubMed:18056975, PubMed:18956248), Essential for the formation of DNA replication focal centers (PubMed:18346216, PubMed:18956248), Has an important role in maintaining genome stability (PubMed:18346216, PubMed:18956248)


This is DNA-directed RNA polymerase II subunit Rpb4 protein, from Fruit fly, contains 139 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Associates with POLR2G

Belongs to the eukaryotic RPB4 RNA polymerase subunit family


This is Mediator of RNA polymerase II transcription subunit 17 protein, from Fruit fly, contains 642 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, Required for activated transcription of the MtnA, MtnB and MtnD genes, Negatively regulates sex comb development

Belongs to the Mediator complex subunit 17 family


This is Chorion peroxidase protein, from Fruit fly, contains 809 amino acids, is soluble, locates in Extracellular.

Required for ovarian follicle maturation, Involved in the formation of a rigid and insoluble egg chorion by catalyzing chorion protein cross-linking through dityrosine formation and phenol oxidase-catalyzed chorion melanization

Belongs to the peroxidase family, XPO subfamily


This is Neuropeptide F protein, from Fruit fly, contains 102 amino acids, is soluble, locates in Extracellular.

Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development, Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain, NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion, NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation, NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents, Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively, Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference


This is Serine protease HTRA2, mitochondrial protein, from Fruit fly, contains 422 amino acids, is membrane-bound, locates in Mitochondrion.

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein, Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism, Can antagonize antiapoptotic activity of th by directly inducing the degradation of th


This is L-dopachrome tautomerase yellow-f2 protein, from Fruit fly, contains 452 amino acids, is soluble, locates in Extracellular.

Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI), Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome, May play a role in melanization reactions during late pupal and adult stages

Belongs to the major royal jelly protein family


This is L-dopachrome tautomerase yellow-f protein, from Fruit fly, contains 429 amino acids, is soluble, locates in Extracellular.

Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI), Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome, May play a role in melanization reactions during late pupal and adult stages, May play a role in melanization reactions during larval and early pupal stages


This is Protein hugin protein, from Fruit fly, contains 191 amino acids, is soluble, locates in Extracellular.


This is Cytochrome P450 315a1, mitochondrial protein, from Fruit fly, contains 520 amino acids, is membrane-bound, locates in Mitochondrion.

Required for CNS development: midline glial cells, Involved in the metabolism of insect hormones: responsible for ecdysteroid C2-hydroxylase activity, May be involved in the breakdown of synthetic insecticides


This is Prefoldin subunit 3 protein, from Fruit fly, contains 194 amino acids, is soluble, locates in Cytoplasm.

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it, Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity), Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl

Belongs to the prefoldin subunit alpha family


This is RuvB-like helicase 1 protein, from Fruit fly, contains 456 amino acids, locates in Nucleus.

Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair


This is ATP-dependent RNA helicase bel protein, from Fruit fly, contains 798 amino acids, is soluble, locates in Cytoplasm.

ATP-dependent RNA helicase that is essential and required for cellular function, larval growth, and for male and female fertility, Also required for RNA interference (RNAi), double-stranded RNA induces potent and specific gene silencing, by acting downstream of dsRNA internalization, RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger

Belongs to the DEAD box helicase family, DDX3/DED1 subfamily


This is Eukaryotic initiation factor 4A-III protein, from Fruit fly, contains 399 amino acids, locates in Nucleus.

ATP-dependent RNA helicase (PubMed:22961380), Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:14973490, PubMed:22961380), Involved in exon definition of genes containing long introns, including the rolled/MAPK gene (PubMed:20946982, PubMed:20946983), Has a role in oskar mRNA localization at the posterior pole of the developing oocyte (PubMed:14973490)


This is GDP-fucose transporter 1 protein, from Fruit fly, contains 337 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in GDP-fucose import from the cytoplasm into the Golgi lumen, Plays a major role in the fucosylation of N-glycans, Functions redundantly with Efr in the O-fucosylation of Notch, positively regulating Notch signaling

Belongs to the TPT transporter family, SLC35C subfamily


This is ADP-ribosylation factor-like protein 8 protein, from Fruit fly, contains 186 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for normal functioning of the late endocytic pathway including lysosome motility and late endosome-lysosome fusion (PubMed:16537643, PubMed:29940804, PubMed:30115618), Not required for the delivery of lysosomal membrane protein-containing vesicles to late endosomes (PubMed:29940804), In larval motorneurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (PubMed:30174114, PubMed:30115618), Essential role in chromosome segregation (PubMed:15331635)

Belongs to the small GTPase superfamily, Arf family


This is Protein grindelwald protein, from Fruit fly, contains 241 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a receptor for egr, Plays a role in activation of JNK signaling and is required for egr-induced apoptosis, May also play an egr-independent role in cell proliferation


This is Conserved oligomeric Golgi complex subunit 5 protein, from Fruit fly, contains 751 amino acids, is membrane-bound, locates in Golgi apparatus.

Required for normal Golgi function and necessary during spermatogenesis, Required for cleavage furrow ingression during cytokinesis in dividing spermatocytes and for the extensive polarized cell growth that accompanies spermatid elongation


This is Zinc finger protein weckle protein, from Fruit fly, contains 470 amino acids, has 6 C2H2-type Zinc finger, is membrane-bound, locates in Cell membrane.

Acts as an adapter to assemble/stabilize a Toll/wek/Myd88/tube complex; required for efficient recruitment of Myd88 to Toll, Dispensable for innate immune response; plays a minimal role, if any, in the immune defense against Gram-positive bacteria and fungi, Involved in dorsoventral axis determination


This is Protein Dr1 protein, from Fruit fly, contains 183 amino acids, locates in Nucleus.

Bifunctional basic transcription factor, Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements (PubMed:11062130), Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucelosome remodeling complexes (PubMed:18327268)


This is Partner of bursicon protein, from Fruit fly, contains 141 amino acids, is soluble, locates in Extracellular.

Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading, Heterodimer specifically activates the G protein-coupled receptor rk


This is Mitochondrial cardiolipin hydrolase protein, from Fruit fly, contains 253 amino acids, is membrane-bound, locates in Mitochondrion.

Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process, Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process, Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization, piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons, Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis

Belongs to the phospholipase D family, MitoPLD/Zucchini subfamily


This is Coiled-coil and C2 domain-containing protein 1-like protein, from Fruit fly, contains 816 amino acids, is soluble, locates in Cytoplasm.

Negative regulator of the Notch signaling pathway, acting to restrict the activity of Notch to the dorsoventral (D/V) boundary of the wing imaginal disk, Also causes negative regulation of Notch during vein, eye, and bristle development, Acts by targeting Notch for endosomal degradation or recycling


This is CD2 antigen cytoplasmic tail-binding protein 2 homolog protein, from Fruit fly, contains 319 amino acids, locates in Nucleus.

Required for embryonic epithelial tissue repair, but not for the assembly of the actomyosin cable at the wound edge, Probably acts downstream of rl in the regulation of Ddc and msn transcription to promote wound healing


This is Dolichyl-phosphate beta-glucosyltransferase protein, from Fruit fly, contains 326 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for normal production of N-glycosylated proteins in the endoplasmic reticulum (ER), Required for embryonic segmentation, dorsal-ventral patterning and gastrulation, Required for chitin orientation and shaping of the apical and lateral plasma membranes of epidermal cells during cuticle differentiation, Also required for correctly shaping apical membrane topology of the epithelia of other organs such as the midgut and the hindgut

Belongs to the glycosyltransferase 2 family


This is Odorant receptor coreceptor protein, from Fruit fly, contains 486 amino acids, is membrane-bound, locates in Cell membrane.

Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability, Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors, Expression of Orco alone leads to formation of rapid and transient ion channels not directly responding to odorants, but directly activated by intracellular cAMP or cGMP, Snmp, Or67d and lush act in concert to capture fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA) molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex

Belongs to the insect chemoreceptor superfamily, Heteromeric odorant receptor channel (TC 1,A,69) family, Orco subfamily


This is KRR1 small subunit processome component homolog protein, from Fruit fly, contains 345 amino acids, locates in Nucleus.

Required for 40S ribosome biogenesis, Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly, Binds to RNA, Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development


This is GATOR complex protein MIOS protein, from Fruit fly, contains 867 amino acids, locates in Nucleus.

An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823, PubMed:23723238), The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823, PubMed:23723238), GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:21521741, PubMed:25512509, PubMed:14973288, PubMed:23723238), This component is required for activating TORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate (PubMed:27166823, PubMed:21521741, PubMed:23723238), GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:21521741, PubMed:25512509, PubMed:14973288, PubMed:23723238), After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509), At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509), In addition to its role in the regulation of the TORC1 complex, functions independently of TORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823)


This is EGF domain-specific O-linked N-acetylglucosamine transferase protein, from Fruit fly, contains 520 amino acids, is soluble, locates in Endoplasmic reticulum.

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc), Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains, Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp)


This is Early boundary activity protein 2 protein, from Fruit fly, contains 381 amino acids, locates in Nucleus.

The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis, It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity (PubMed:23240086), Elba2 can act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495)


This is Early boundary activity protein 1 protein, from Fruit fly, contains 363 amino acids, locates in Nucleus.

The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis, It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity (PubMed:23240086), Elba1 may act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression (PubMed:25561495)


This is Flap endonuclease GEN protein, from Fruit fly, contains 726 amino acids, locates in Nucleus.

Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA, Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded, Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded, Also possesses weak 5'- to 3'-exonuclease activity on nicked but not gapped double-stranded DNA, Does not cleave bubble-like or Holliday junction substrates

Belongs to the XPG/RAD2 endonuclease family, GEN subfamily


This is Forkhead box protein biniou protein, from Fruit fly, contains 676 amino acids, locates in Nucleus.

Component of a regulatory network controlling visceral mesoderm development and midgut morphogenesis, Transcriptional regulator involved in the activation of a large number of genes in the visceral mesoderm including betaTub60D, dpp and Hand, Binds to and regulates a number of enhancers driving expression in the visceral mesoderm in a temporally and spatially restricted manner, Also to binds to enhancers cooperatively with activators, such as bap or HLH54F, to coregulate expression of shared target genes in the visceral mesoderm, Binds to the Ndg enhancer and drives expression of Ndg in the late visceral musculature, May be involved in the transcriptional regulation of wupA in the visceral mesoderm, Plays an indirect role in the later stages of salivary gland positioning


This is Akirin protein, from Fruit fly, contains 201 amino acids, locates in Nucleus.

Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is required for embryonic development and for normal innate immune response (PubMed:18066067, PubMed:22396663, PubMed:25180232, PubMed:32950464), Acts as a regulator of embryonic myogenesis by bridging Twist (twi) with the SWI/SNF-like Brahma complex, promoting expression of twi-regulated genes during myogenesis (PubMed:22396663), Effector of immune deficiency pathway (Imd) by acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel) (PubMed:18066067, PubMed:25180232, PubMed:32950464), Acts by bridging the NF-kappa-B factor Rel and the Brahma complex through bap60 interaction, leading to activation a subset of NF-kappa-B factor Relish (Rel) effector genes (PubMed:25180232), Not part of the Toll pathway (PubMed:18066067), Required for the formation of the heart by promoting expression ot tinman (tin) (PubMed:32950464)


This is Ceramide phosphoethanolamine synthase protein, from Fruit fly, contains 600 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A phosphatidylethanolamine (PE)/ceramide ethanolamine phosphotransferase that catalyzes the synthesis of ceramide phosphoethanolamines (CPE), a class of lipids that is a sphingomyelin analog and a major membrane constituent in Drosophila, Transfers the head group from PE (1,2-diacyl-sn-glycero-3-phosphoethanolamine) on to different ceramides such as N-acylsphinganine (dihydroceramide) and N-acyl-(4R)-hydroxysphinganine (phytoceramide) to form N-acyl-sphinganine-1-phosphoethanolamine and N-acyl-(4R)-hydroxysphinganine-1-phosphoethanolamine, respectively, Operates as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum, which is critical for the integrity of the early secretory pathway

Belongs to the sphingomyelin synthase family


This is Zinc transporter foi protein, from Fruit fly, contains 706 amino acids, is membrane-bound, locates in Cell membrane.

Required for the normal migration of longitudinal and peripheral glial cells, During larval development, required for the migration of the subretinal glia into the eye disk, During embryonic development, also controls the migration of muscle cells toward their attachment sites, Required in the mesoderm for the correct morphogenesis of embryonic gonad and for tracheal branch fusion during tracheal development, Shg may be cooperating with foi to mediate a common mechanism for gonad and tracheal morphogenesis, Acts as a zinc transporter in both yeast and mammalian cells

Belongs to the ZIP transporter (TC 2,A,5) family


This is Cyclin-dependent kinase 8 protein, from Fruit fly, contains 454 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors, May phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex, Required for leg and eye development and macrochaete specification or differentiation

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily


This is Protein O-mannosyltransferase 1 protein, from Fruit fly, contains 886 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development

Belongs to the glycosyltransferase 39 family


This is PCI domain-containing protein 2 homolog protein, from Fruit fly, contains 395 amino acids, locates in Cytoplasm.

Required for the export of nuclear mRNAs and involved in mRNA trafficking in the cytoplasm (PubMed:27016737, PubMed:28554770, PubMed:33602059), Component of the nuclear pore complex (NPC)-associated TREX-2/AMEX complex (anchoring and mRNA export complex) which functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), thereby enabling the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:27016737, PubMed:28554770, PubMed:33602059), Within the complex, specifically promotes the association of factors involved in regulating nuclear mRNA export, such as Moe, sbr/NXF1 and the ORC complex, to the mRNPs particles (PubMed:27016737, PubMed:28554770, PubMed:33602059), In the cytoplasm, functions independently of its role in the TREX-2/AMEX complex, to promote cytoplasmic mRNA trafficking together with nudC (PubMed:33602059), Associates with translationally active polysomes (PubMed:18086857)


This is Actin-interacting protein 1 protein, from Fruit fly, contains 608 amino acids, is soluble, locates in Cytoplasm.

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:17565945), Together with GMF, promotes Arp2/3-nucleated actin filament array disassembly (PubMed:25308079), Essential for organismal and cell viability (PubMed:17565945), Required for the development of normal wing cell planar polarity (PubMed:17565945), In egg chambers and together with GMF, plays an important role in directional migration of border cell clusters (PubMed:25308079)


This is Vacuolar protein-sorting-associated protein 36 protein, from Fruit fly, contains 399 amino acids, is soluble, locates in Cytoplasm.

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:19132102), The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:19132102), The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity), ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA (PubMed:17268469), This interaction is required for the anterior localization of bicoid mRNA in the developing egg (PubMed:17268469), Plays a role in promoting mitochondrial autophagy (mitophagy) (PubMed:29307555)


This is Ecdysone 20-monooxygenase protein, from Fruit fly, contains 540 amino acids, is membrane-bound, locates in Mitochondrion.

Required for CNS development; midline glial cells, Involved in the metabolism of insect hormones; responsible for all ecdysone 20-monooxygenase activity during embryonic, larval and adult stages, May be involved in the breakdown of synthetic insecticides


This is CTP synthase protein, from Fruit fly, contains 627 amino acids, is soluble, locates in Cytoplasm.

Required for assembly of cytoophidium in female germline cells (PubMed:23459760, PubMed:25223282), In nurse cells, CTPsyn filament assembly in the cytoophidium is regulated by Ack kinase which may thereby contribute to the control of CTP production at specific stages of oogenesis and development of the nurse cell membrane (PubMed:25223282)


This is Adenosine 3'-phospho 5'-phosphosulfate transporter 2 protein, from Fruit fly, contains 396 amino acids, is membrane-bound, locates in Golgi apparatus.

Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi, PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi, Essential for viability, Involved in glycosaminoglycan synthesis and the subsequent signaling, May be involved in hh and dpp signaling by controlling the sulfation of heparan sulfate (HS)

Belongs to the nucleotide-sugar transporter family, SLC35B subfamily


This is Enhancer of mRNA-decapping protein 3 protein, from Fruit fly, contains 680 amino acids, is soluble, locates in Cytoplasm.

In the process of mRNA degradation, may play a role in mRNA decapping


This is ATR-interacting protein mus304 protein, from Fruit fly, contains 846 amino acids, is soluble, locates in Cytoplasm.

DNA damage checkpoint protein required for chromosome break repair and for genomic stability during development


This is Protein aurora borealis protein, from Fruit fly, contains 539 amino acids, locates in Cytoplasm.

Required for the activation of Aurora-A (aur) at the onset of mitosis


This is Protein I'm not dead yet protein, from Fruit fly, contains 590 amino acids, is membrane-bound, locates in Cell membrane.

Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates, There is also small, but detectable, transport of monocarboxylics, Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage, Affinity for substrates is citrate > succinate > pyruvate, Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate, Transport mechanism that is not coupled to Na(+), K(+), or Cl(-), Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines

Belongs to the SLC13A/DASS transporter (TC 2,A,47) family, NADC subfamily


This is Dual specificity protein phosphatase Mpk3 protein, from Fruit fly, contains 411 amino acids, is soluble, locates in Cytoplasm.

Negatively regulates the activity of members of the MAP kinase family in response to changes in the cellular environment, Has a specificity for the ERK family, Acts as negative regulator in a variety of developmental processes including cell differentiation and proliferation controlled by the Ras/ERK pathway, Suppresses the photoreceptor cell differentiation and wing vein formation, Required for proper oogenesis and early embryogenesis, Functions autonomously in a subset of photoreceptor progenitor cells in eye imaginal disks, Appears also to be required in surrounding non-neuronal cells for ommatidial patterning and photoreceptor differentiation, Plays a role in the maintenance of epithelial integrity during tracheal development

Belongs to the protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily


This is Protein Gemin2 protein, from Fruit fly, contains 245 amino acids, is soluble, locates in Cytoplasm.

The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:18621711, PubMed:23333303), Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity), In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG (5Sm) are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity), To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A (By similarity), Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity), Within the SMN complex, GEMIN2 constrains the conformation of 5Sm, thereby promoting 5Sm binding to snRNA containing the snRNP code (a nonameric Sm site and a 3'-adjacent stem-loop), thus preventing progression of assembly until a cognate substrate is bound (By similarity)


This is Frizzled-2 protein, from Fruit fly, contains 694 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for Wnt proteins, Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes, A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase, Both pathways seem to involve interactions with G-proteins, Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles

Belongs to the G-protein coupled receptor Fz/Smo family


This is Possible lysine-specific histone demethylase 1 protein, from Fruit fly, contains 890 amino acids, locates in Nucleus.

Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Required for heterochromatic gene silencing, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Demethylates both mono- and tri-methylated 'Lys-4' of histone H3, May also demethylate 'Lys-9' of histone H3, Plays a role in the repression of neuronal genes

Belongs to the flavin monoamine oxidase family


This is Serine/threonine-protein kinase S6KL protein, from Fruit fly, contains 483 amino acids, is soluble, locates in Cytoplasm.

Displays kinase activity, Inhibits neuromuscular junction (NMJ) growth by interacting with and promoting the proteasome-mediated degradation of the receptor tkv which inhibits bone morphogenetic protein (BMP) signaling

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Cytochrome P450 306a1 protein, from Fruit fly, contains 574 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the metabolism of insect hormones; responsible for ecdysteroid C25-hydroxylase activity, May be involved in the breakdown of synthetic insecticides


This is Tumor necrosis factor receptor superfamily member wengen protein, from Fruit fly, contains 343 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for egr (PubMed:12084706, PubMed:12894227), Involved in induction of apoptosis by triggering JNK signaling (PubMed:12894227), Mediates the tumor suppressor activity of egr which eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity (PubMed:19289090), Following UV-induced epidermal damage, binds to egr released from apoptotic epidermal cells and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious (PubMed:19375319), Together with Moe, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr (PubMed:23544124)


This is Serine protease persephone protein, from Fruit fly, contains 394 amino acids, is soluble, locates in Extracellular.

Serine protease that plays a key role in innate immunity in response to Gram-positive bacterial and fungal proteases (PubMed:12098703, PubMed:18724373, PubMed:16399077), Acts as a component of the Toll pathway upstream of protease spz processing enzyme SPE and Tl ligand spz (PubMed:12098703, PubMed:18724373, PubMed:16399077), Nec regulates the cascade by inhibiting psh (PubMed:12098703)

Belongs to the peptidase S1 family, CLIP subfamily


This is Protein-serine O-palmitoleoyltransferase porcupine protein, from Fruit fly, contains 525 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins, Serine palmitoleoylation of Wnt proteins is required for efficient binding to frizzled receptors (By similarity), Also facilitates the glycosylation of Wnt family members, including wg and Wnt5, The cotranslational disulfide bond formation of wg competes with the N-glycosylation, Porc stimulates the post-translational N-glycosylation by anchoring wg at the ER membrane, probably through acylation (PubMed:11821428, PubMed:15166250, PubMed:22108505, PubMed:8985181)

Belongs to the membrane-bound acyltransferase family, Porcupine subfamily


This is Cyclic AMP response element-binding protein B protein, from Fruit fly, contains 359 amino acids, locates in Nucleus.

Isoform E is a PKA-dependent transcriptional activator, Isoform J is a direct antagonist of activation by isoform E in cell culture, Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters (PubMed:7651429, PubMed:15219829), Has a role in long-term memory (PubMed:29473541)

Belongs to the bZIP family, ATF subfamily


This is Peptidoglycan-recognition protein LE protein, from Fruit fly, contains 345 amino acids, is soluble, locates in Extracellular.

Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to murein peptidoglycans (PGN) of Gram-negative bacteria and activating the imd/Relish pathway, Has no activity against on Gram-positive bacteria, Binds to diaminopimelic acid-type PGN (DAP-type PGN), an activator of the imd/Relish pathway, Functions synergistically with PGRP-LC in producing resistance to E,coli and B,megaterium infections, which have the DAP-type peptidoglycan, Acts both upstream and in parallel with PGRP-LC in the imd/Relish pathway, and is required for infection-dependent activation of melanization, Required for Relish processing and nuclear translocation following proteolytic cleavage, Its localization suggests a role in the recognition and subsequent activation of the signaling at the first point of contact with invading bacteria

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family


This is Protein-tyrosine sulfotransferase protein, from Fruit fly, contains 499 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (By similarity), Has a role in protein secretion

Belongs to the protein sulfotransferase family


This is Peptidoglycan-recognition protein SA protein, from Fruit fly, contains 203 amino acids, is soluble, locates in Extracellular.

Peptidoglycan-recognition protein that plays a key role in innate immunity by binding to peptidoglycans (PGN) of Gram-positive bacteria and activating the Toll pathway upstream of spz activating enzyme SPE (PubMed:11106397, PubMed:16399077, PubMed:15448690), Has no activity against Gram-negative bacteria and fungi (PubMed:11742401), Shows some partial redundancy with PRPGP-SD in Gram-positive bacteria recognition (PubMed:11742401, PubMed:15448690), May act by forming a complex with GNBP1 that activates the proteolytic cleavage of Spatzle and the subsequent activation of Toll pathway (PubMed:14684822, PubMed:14722090, PubMed:11742401), Binds to diaminopimelic acid-type tetrapeptide PGN (DAP-type PGN) and lysine-type PGN (Lys-type PGN) (PubMed:15361936), Has some L,D-carboxypeptidase activity for DAP-type PGN, which are specific to prokaryotes, but not for Lys-type PGN (PubMed:15361936)


This is Protein ecdysoneless protein, from Fruit fly, contains 684 amino acids, is soluble, locates in Cytoplasm.

Required in both the follicle cells and the germline for oocyte development


This is Protein painting of fourth protein, from Fruit fly, contains 495 amino acids, locates in Nucleus.

Probable RNA-binding protein that specifically binds to the fourth chromosome and may bind an RNA that spreads the fourth chromosome, May be a reminiscence of X chromosome dosage compensation of ancestral Drosophila species in which the X and the fourth chromosomes are one single chromosome


This is Breast cancer type 2 susceptibility protein homolog protein, from Fruit fly, contains 971 amino acids, locates in Nucleus.

Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination, During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint


This is Inactive peptidyl-prolyl cis-trans isomerase shutdown protein, from Fruit fly, contains 455 amino acids, is soluble, locates in Cytoplasm.

Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity, Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons, Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations


This is RNA polymerase-associated protein Rtf1 protein, from Fruit fly, contains 775 amino acids, is soluble, locates in Nucleus.

Plays a role in transcription-coupled histone modification, Required for methylation of 'Lys-4' of histone H3, Plays a role in regulation of transcription, Required for maximal induction of heat-shock genes, Plays a role in Notch signaling in the wing margins


This is Protein panoramix protein, from Fruit fly, contains 541 amino acids, locates in Nucleus.

Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26472911, PubMed:26494711), Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts (PubMed:26472911, PubMed:26494711), Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (PubMed:26472911), In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064), The interaction with nxf2 stabilizes the nuclear protein complex (PubMed:31384064)


This is Chitinase-like protein Idgf4 protein, from Fruit fly, contains 442 amino acids, is soluble, locates in Extracellular.

Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells, May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex

Belongs to the glycosyl hydrolase 18 family, IDGF subfamily


This is Synembryn protein, from Fruit fly, contains 573 amino acids, is soluble, locates in Cytoplasm.

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors, Acts by exchanging bound GDP for free GTP, Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i) alpha protein independently of G-protein coupled receptors, In addition to its GEF activity, it plays an essential role in cortical subcellular localization of heterotrimeric G proteins, suggesting it acts as a facilitator of G-alpha function through control of its membrane targeting and/or assembling of associated components rather than a GEF, Also required during gastrulation and sensory organ precursors (SOP) formation


This is Protein shifted protein, from Fruit fly, contains 456 amino acids, is soluble, locates in Extracellular.

Required for normal accumulation and movement of lipid-modified hedgehog (hh) morphogen, May act by stabilizing the interaction between heparan sulfate proteoglycans (HSPGs) and hh, HSPGs being required for diffusion of hh morphogen, Not involved in wingless (wg) morphogen movement, suggesting that it may provide HSPG specificity for Hh


This is tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho protein, from Fruit fly, contains 424 amino acids, locates in Nucleus.

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit, Required during gametogenesis


This is UDP-xylose and UDP-N-acetylglucosamine transporter protein, from Fruit fly, contains 352 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose, Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling, Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk


This is G-protein coupled receptor moody protein, from Fruit fly, contains 670 amino acids, is membrane-bound, locates in Cell membrane.

Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function, A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors, Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation, The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the formation of septate junctions of sufficient length to achieve proper sealing of the nerve cord

Belongs to the G-protein coupled receptor 1 family


This is Large subunit GTPase 1 homolog protein, from Fruit fly, contains 606 amino acids, is soluble, locates in Cytoplasm.

GTPase required for the nuclear export of the 60S ribosomal subunit, Probably acts by mediating the release of Nmd3 from the 60S ribosomal subunit after export into the cytoplasm, Regulator of body size; acts in serotonergic neurons to regulate insulin signaling and thus exerts global growth control

Belongs to the TRAFAC class YlqF/YawG GTPase family, LSG1 subfamily


This is Protein O-mannosyl-transferase 2 protein, from Fruit fly, contains 765 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development


This is Chromodomain Y-like protein protein, from Mouse, contains 593 amino acids, locates in Nucleus.

Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain


This is Basic helix-loop-helix ARNT-like protein 1 protein, from Mouse, contains 632 amino acids, locates in Cytoplasm.

Transcriptional activator which forms a core component of the circadian clock, The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior, It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function, Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system, Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'), The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN, The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle, Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day, Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle), A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively, Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging, A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism, Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters, The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression, This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively, BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway, Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM, Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR, Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms, Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth, Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit, Regulates the circadian expression of CIART and KLF11, The CLOCK-BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism, Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors, May play a role in spermatogenesis; contributes to the chromatoid body assembly and physiology, The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina, The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (By similarity), CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3' (By similarity), The CLOCK-BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (By similarity), Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504), Plays a role in protecting against lethal sepsis by limiting the expression of immune checkpoint protein CD274 in macrophages in a PKM2-dependent manner (PubMed:29996098), Regulates the diurnal rhythms of skeletal muscle metabolism via transcriptional activation of genes promoting triglyceride synthesis (DGAT2) and metabolic efficiency (COQ10B) (PubMed:30096135)


This is E3 ubiquitin-protein ligase RLIM protein, from Mouse, contains 600 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex, Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM, Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1, By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals


This is Aquaporin-5 protein, from Mouse, contains 265 amino acids, is membrane-bound, locates in Cell membrane.

Forms a water-specific channel (By similarity), Plays an important role in fluid secretion in salivary glands (PubMed:10400615, PubMed:16571723, PubMed:18027168), Required for TRPV4 activation by hypotonicity, Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723), Seems to play a redundant role in water transport in the eye, lung and in sweat glands (PubMed:10619865, PubMed:12042359, PubMed:18027168)

Belongs to the MIP/aquaporin (TC 1,A,8) family


This is KH domain-containing, RNA-binding, signal transduction-associated protein 2 protein, from Mouse, contains 349 amino acids, locates in Nucleus.

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (By similarity), Binds both poly(A) and poly(U) homopolymers, Phosphorylation by PTK6 inhibits its RNA-binding ability, Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer (By similarity), Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners, Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping, In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4 (PubMed:22196734, PubMed:24469635), Its phosphorylation by FYN inhibits its ability to regulate splice site selection (By similarity), May function as an adapter protein for Src kinases during mitosis (PubMed:10077576)


This is LIM/homeobox protein Lhx9 protein, from Mouse, contains 397 amino acids, locates in Nucleus.


This is Solute carrier family 2, facilitated glucose transporter member 5 protein, from Mouse, contains 501 amino acids, is membrane-bound, locates in Cell membrane.

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:12031501, PubMed:19091748), Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity), Essential for fructose uptake in the small intestine (PubMed:19091748, PubMed:26071406), Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (PubMed:19091748), Required for the development of high blood pressure in response to high dietary fructose intake (PubMed:19091748)

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily


This is Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] protein, from Mouse, contains 292 amino acids, locates in Peroxisome.

Auxiliary enzyme of beta-oxidation, Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome, Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA, Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid

Belongs to the short-chain dehydrogenases/reductases (SDR) family, 2,4-dienoyl-CoA reductase subfamily


This is Syntaxin-binding protein 4 protein, from Mouse, contains 557 amino acids, is soluble, locates in Cytoplasm.

Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane, Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2, Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane, May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose


This is Hairy/enhancer-of-split related with YRPW motif protein 1 protein, from Mouse, contains 299 amino acids, locates in Nucleus.

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3', Downstream effector of Notch signaling required for cardiovascular development, Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development, May be required in conjunction with HEY2 to specify arterial cell fate or identity, Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification, Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3


This is Synaptojanin-2-binding protein protein, from Rat, contains 145 amino acids, is membrane-bound, locates in Mitochondrion.

Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction


This is MORC family CW-type zinc finger protein 1 protein, from Mouse, contains 950 amino acids, has 1 CW-type Zinc finger, locates in Nucleus.

CW-type

Required for spermatogenesis (PubMed:10369865, PubMed:25503965), Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (PubMed:25503965), Not required for piRNA biosynthesis (PubMed:25503965)


This is C-X-C motif chemokine 15 protein, from Mouse, contains 167 amino acids, is soluble, locates in Extracellular.

Chemotactic for neutrophils, Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions

Belongs to the intercrine alpha (chemokine CxC) family


This is Interferon-induced GTP-binding protein Mx2 protein, from Mouse, contains 655 amino acids, is soluble, locates in Cytoplasm.

Interferon-induced dynamin-like GTPase with antiviral activity against vesicular stomatitis virus (VSV) and Hantaan virus (HNTV)

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Menin protein, from Rat, contains 610 amino acids, locates in Nucleus.

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4), Functions as a transcriptional regulator, Binds to the TERT promoter and represses telomerase expression, Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA, Positively regulates HOXC8 and HOXC6 gene expression, May be involved in normal hematopoiesis through the activation of HOXA9 expression, May be involved in DNA repair (By similarity), Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity


This is MAPK/MAK/MRK overlapping kinase protein, from Mouse, contains 420 amino acids, is soluble, locates in Cytoplasm.

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (PubMed:10421840), Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner (PubMed:25243405)

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily


This is Protein OSCA1 protein, from Mouse-ear cress, contains 772 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions (PubMed:25162526, PubMed:30190597), Shows the following permeability sequence: K(+) > Ba(2+) = Ca(2+) > Na(+) = Mg(2+) = Cs(+) (PubMed:25162526), Mechanosensitive ion channel that converts mechanical stimuli into a flow of ions (PubMed:30190597)


This is Cysteine-rich receptor-like protein kinase 36 protein, from Mouse-ear cress, contains 658 amino acids, is membrane-bound, locates in Cell membrane.

Forms a complex with CRK45 that may negatively control abscisic acid (ABA) and osmotic stress signal transduction, Can phosphorylate CRK45 in vitro (PubMed:22225700)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CRK subfamily


This is Peroxiredoxin-2B protein, from Mouse-ear cress, contains 162 amino acids, is soluble, locates in Cytoplasm.

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively, Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events

Belongs to the peroxiredoxin family, Prx5 subfamily


This is 3-ketoacyl-CoA synthase 6 protein, from Mouse-ear cress, contains 497 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Contributes to cuticular wax and suberin biosynthesis, Involved in both decarbonylation and acyl-reduction wax synthesis pathways, Required for elongation of C24 fatty acids, an essential step of the cuticular wax production (PubMed:10330468, PubMed:11041893), Major condensing enzyme for stem wax and pollen coat lipid biosynthesis (PubMed:12467640)

Belongs to the thiolase-like superfamily, Chalcone/stilbene synthases family


This is Aquaporin PIP1-2 protein, from Maize, contains 289 amino acids, is membrane-bound, locates in Cell membrane.

Water channel required to facilitate the transport of water across cell membrane, Active as heteromers with PIP1-1, PIP2-1, PIP2-4 or PIP2-5, but not as homomers

Belongs to the MIP/aquaporin (TC 1,A,8) family, PIP (TC 1,A,8,11) subfamily


This is Microtubule nucleation factor SSNA1 protein, from Chlamydomonas smithii, contains 111 amino acids, locates in Nucleus.

Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage (By similarity), Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules (PubMed:30250060), Required for cell division (PubMed:12640030)


This is Chlorophyll a-b binding protein CP26, chloroplastic protein, from Mouse-ear cress, contains 280 amino acids, is membrane-bound, locates in Plastid.

The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated

Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family


This is Thioredoxin F1, chloroplastic protein, from Mouse-ear cress, contains 178 amino acids, is soluble, locates in Plastid.

Thiol-disulfide oxidoreductase involved in the redox regulation of enzymes of both reductive pentose phosphate pathway (Calvin-Benson cycle) and oxidative pentose phosphate pathway, Under light or reducing conditions, activates in chloroplast the glyceraldehyde-3-phosphate dehydrogenase, the phosphoribulokinase and the fructose-1,6-bisphosphate phosphatase, and inhibits the glucose-6-phosphate dehydrogenase

Belongs to the thioredoxin family, Plant F-type subfamily


This is Oxygen-evolving enhancer protein 3-1, chloroplastic protein, from Mouse-ear cress, contains 224 amino acids, is membrane-bound, locates in Plastid.

Required for photosystem II assembly/stability and photoautotrophic growth under low light conditions


This is 12-oxophytodienoate reductase 1 protein, from Tomato, contains 376 amino acids, is soluble, locates in Cytoplasm.

Specifically cleaves olefinic bonds in alpha,beta-unsaturated carbonyls and may be involved in detoxification or modification of these reactive compounds, May be involved in the biosynthesis or metabolism of oxylipin signaling molecules, In vitro, reduces 9R,13R-12-oxophyodienoic acid (9R,13R-OPDA) to 9R,13R-OPC-8:0, but not 9S,13S-OPDA, the natural precursor of jasmonic acid, Also reduces N-ethylmaleimide and maleic acid

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family


This is Tricin synthase 1 protein, from Rice, contains 252 amino acids, locates in Nucleus.

Catalyzes the stepwise methylation of tricetin to its 3'-mono- and 3',5'-dimethyl ethers, No 3',4',5'-trimethylated ester derivatives are produced, Can use caffeoyl-CoA, 5-hydroxyferulic acid, luteolin, tricetin, quercetin, myrcetin and 7,8-dihydroxyflavone as substrates, but not naringenin, apigenin or kaempferol, The 2,3-double bond and the O-dihydroxyl group of the substrate are both required for catalytic activity of the enzyme

Belongs to the class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family, CCoAMT subfamily


This is NADP-dependent malic enzyme 3 protein, from Mouse-ear cress, contains 588 amino acids, is soluble, locates in Cytoplasm.


This is Transcription factor MYB80 protein, from Mouse-ear cress, contains 320 amino acids, locates in Nucleus.

Transcription factor that binds to the DNA sequence 5'-CCAACC-3', Regulates directly PME5, UND and GLOX1 (PubMed:21673079), Essential for tapetum development in anthers and microsporogenesis (PubMed:12848824, PubMed:21673079), Regulates the timing of tapetal programmed cell death (PCD) which is critical for pollen development, May act through the activation of UND, encoding an A1 aspartic protease (PubMed:21673079), Required for anther development by regulating tapetum development, callose dissolution and exine formation, Acts upstream of A6 and FAR2/MS2, two genes required for pollen exine formation (PubMed:17727613), Negatively regulates trichome endoreduplication and trichome branching (PubMed:12848824)


This is Cytochrome c-type biogenesis CcmH-like mitochondrial protein protein, from Mouse-ear cress, contains 159 amino acids, is membrane-bound, locates in Mitochondrion.

Plays a central role in mitochondrial cytochrome c maturation, Probable component of a heme lyase complex involved in the reduction of apocytochrome c (PubMed:16236729), Forms a complex with CCMF proteins (CCMFC, CCMFN1 and CCMFN2) that performs the assembly of heme with c-type apocytochromes in mitochondria (PubMed:18644794)

Belongs to the CcmH/CycL/Ccl2/NrfF family


This is Photosynthetic NDH subunit of lumenal location 2, chloroplastic protein, from Mouse-ear cress, contains 190 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable), Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex (PubMed:20430763, PubMed:20460499)


This is Long chain acyl-CoA synthetase 2 protein, from Mouse-ear cress, contains 665 amino acids, locates in Endoplasmic reticulum.

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation, Acts in the cutin pathway, Preferentially uses palmitate, palmitoleate, oleate and linoleate, Required for repression of lateral root formation through its role in cutin biosynthesis and subsequent aerial tissues permeability

Belongs to the ATP-dependent AMP-binding enzyme family


This is Somatic embryogenesis receptor kinase 2 protein, from Mouse-ear cress, contains 628 amino acids, is membrane-bound, locates in Cell membrane.

Serine/threonine-kinase involved in brassinosteroid-dependent and -independent signaling pathways, Acts redundantly with SERK1 as a control point for sporophytic development controlling male gametophyte production (PubMed:18667726), Serves as coreceptor to small peptide (e,g, RGF1 and CLE44) signaling (Probable), Involved in the perception of phytosulfokine and subsequent signal transduction (PubMed:26308901)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is DExH-box ATP-dependent RNA helicase DExH9 protein, from Mouse-ear cress, contains 988 amino acids, locates in Nucleus.

ATP-dependent RNA helicase that associates with the RNA exosome complex (PubMed:21682783, PubMed:25144737), Required for proper rRNA biogenesis and development, Involved in the 3'-processing of the 7S pre-RNA to the mature 5,8S rRNA and also in the removal of rRNA maturation by-products (PubMed:21682783)

Belongs to the DExH box helicase family, SKI2 subfamily


This is Plastid division protein PDV2 protein, from Mouse-ear cress, contains 307 amino acids, is membrane-bound, locates in Plastid.

Component of the plastid division machinery consisting in a binary fission accomplished by the simultaneous constriction of the FtsZ ring on the stromal side of the inner envelope membrane, and the ARC5/DRP5B ring on the cytosolic side of the outer envelope membrane (PubMed:28248291), Positive factor of chloroplast division required, with a dosage effect, to mediate the recruitment and dimerization of ARC5/DRP5B at the midplastid constriction site in the cytoplasm at plastid outer envelope membranes (OEMs) (PubMed:28248291, PubMed:27988788, PubMed:32005784), Prevents ARC5/DRP5B GTPase acrivity (PubMed:27988788), Relays plastid division site position between stroma and outer surface via interactions with the cytoplasmic ARC5/DRP5B and the inner membrane ARC6 that recruits stromal FtsZ ring (PubMed:28248291), Binding to phosphatidylinositol 4-phosphate (PI4P) modulates negatively chloroplast division (PubMed:25736058)


This is Transcription factor LHW protein, from Mouse-ear cress, contains 650 amino acids, locates in Nucleus.

Transcription activator that regulates root development; promotes the production of stele cells in roots, Coordinately controls the number of all vascular cell types by regulating the size of the pool of cells from which they arise

Belongs to the bHLH protein family, LHW subfamily


This is ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic protein, from Mouse-ear cress, contains 387 amino acids, is soluble, locates in Plastid.

Required for chloroplast development and differentiation


This is ATP-dependent Clp protease proteolytic subunit-related protein 2, chloroplastic protein, from Mouse-ear cress, contains 279 amino acids, locates in Plastid.

Required for chloroplast development and integrity, Involved in the regulation of plastoglobules formation


This is LEM protein 2 protein, from Caenorhabditis elegans, contains 500 amino acids, is membrane-bound, locates in Nucleus.

Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis (PubMed:12684533, PubMed:21176223, PubMed:22171324, PubMed:25653391, PubMed:32271860), In interphase cells, plays a role in anchoring and spatial arrangement of chromosome arms at the nuclear periphery, forming so-called lem-2 subdomains (PubMed:21176223), Both arms of autosomes but only the left arm of the X chromosome are anchored in lem-2 subdomains; sequences bound by lem-2 are mainly repetitive chromosome sequences and inactive genes (PubMed:21176223), Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina (PubMed:12684533), Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells (PubMed:22171324), Involved in the nuclear positioning and efficient anchoring of microtubule-organizing centers (MTOCs) to the nuclear envelope during mitosis as well as on maintaining correct nuclear morphology (PubMed:25653391), Contributes to closure of nuclear envelope (NE) holes and prevents excess nuclear membranes after meiosis and mitosis (PubMed:32271860), Together with emr-1, plays a role in baf-1 enrichment at the nuclear envelope in anaphase (PubMed:12684533), Together with emr-1, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization (PubMed:22171324), May play a role in radiation-induced DNA damage repair response (PubMed:22383942)


This is Zinc finger protein mex-5 protein, from Caenorhabditis elegans, contains 468 amino acids, has 2 C3H1-type Zinc finger, is soluble, locates in Cytoplasm.

Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos (PubMed:10882103, PubMed:18199581, PubMed:18842813, PubMed:30279189), Also affects formation of intestinal cells (PubMed:10882103), Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA (PubMed:27594427), Required for neg-1 expression in anterior blastomeres during embryogenesis (PubMed:26096734)


This is Meiotic recombination protein rec-8 protein, from Caenorhabditis elegans, contains 781 amino acids, locates in Nucleus.

Plays a role in meiotic chromosome cohesion and segregation (PubMed:11390355, PubMed:25171895), Necessary for sister chromatid co-orientation and sister chromatid cohension until meiosis II (PubMed:19574299), May also be required for repair of programmed meiotic double stranded breaks (PubMed:11390355), During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division (PubMed:23401519)

Belongs to the rad21 family, Highly divergent


This is Nicotinic receptor-associated protein 1 protein, from Caenorhabditis elegans, contains 634 amino acids, is membrane-bound, locates in Cell membrane.

Exhibits calcium-dependent phospholipid binding properties (By similarity), May function in membrane trafficking, Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord (PubMed:15990870), Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole (PubMed:15990870), Affects directional sperm motility (PubMed:16998478)


This is Intraflagellar transport associated protein 2 protein, from Caenorhabditis elegans, contains 252 amino acids, is soluble, locates in Cytoplasm.

Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium (PubMed:28479320), May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility (PubMed:28479320), Regulates specific signaling activities in the cilia, such as the daf-2/insulin receptor-like transduction pathway (PubMed:16968739)

Belongs to the small GTPase superfamily, Rab family


This is Serine/threonine-protein phosphatase 4 catalytic subunit 1 protein, from Caenorhabditis elegans, contains 333 amino acids, is soluble, locates in Cytoplasm.

Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis (PubMed:11896188, PubMed:25340746), During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM) (PubMed:11896188), During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulting in chiasma formation (PubMed:11896188, PubMed:25340746), During oocyte meiosis II and probably together with regulatory subunit ppfr-1, may regulate microtubule severing by dephosphorylating and activating mei-1, a component of the katanin microtubule severing complex (PubMed:19087961)

Belongs to the PPP phosphatase family, PP-4 (PP-X) subfamily


This is V-type proton ATPase subunit C protein, from Caenorhabditis elegans, contains 384 amino acids, is soluble, locates in Cytoplasm.

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (Probable), V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity), Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity), Has roles in embryogenesis and ovulation (PubMed:10846178)

Belongs to the V-ATPase C subunit family


This is Orchestin protein, from Amphipod, contains 128 amino acids, is soluble, locates in Extracellular.

Plays a role in cuticle calcification, May induce precipitation of the calcium stored in the posterior caeca as calcium carbonate


This is Mesencephalic astrocyte-derived neurotrophic factor homolog protein, from Fruit fly, contains 173 amino acids, is soluble, locates in Extracellular.

Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity, Essential for maintenance of dopaminergic neurons and dopamine levels


This is Pre-mRNA-splicing regulator female-lethal(2)D protein, from Fruit fly, contains 536 amino acids, locates in Nucleus.

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077), Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:1695150, PubMed:27919077), M6A methylation is also required for neuronal functions (PubMed:27919077), Required for proper inclusion of regulated exons in Ubx transcripts, leading to isoforms Ia/b and IIa/b (PubMed:10101174)


This is BmK-YA precursor protein, from Manchurian scorpion, contains 200 amino acids, is soluble, locates in Extracellular.

Synthetic BmK-YA activates human opioid receptors in vitro, with highest activity on the delta-type/OPRD1 receptor (EC(50)=2,5 uM) and lower activity on mu-type/OPRM1 and kappa-type/OPRK1 receptors (EC(50)=17 uM and 30 uM, respectively)


This is Myotubularin-related protein 6 protein, from Human, contains 621 amino acids, locates in Nucleus.

Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598), Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable), Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970), Negatively regulates ER-Golgi protein transport (By similarity), Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580), Acts as a negative regulator of KCNN4/KCa3,1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468), Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315), In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598), The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is 60S ribosome subunit biogenesis protein NIP7 homolog protein, from Human, contains 180 amino acids, locates in Nucleus.

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly


This is Cyclin-D-binding Myb-like transcription factor 1 protein, from Human, contains 760 amino acids, locates in Nucleus.

Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity), Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity), Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene, Isoform 2 may antagonize transcriptional activation by isoform 1


This is RING finger protein 24 protein, from Human, contains 148 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Golgi apparatus.

RING-type

May play a role in TRPCs intracellular trafficking


This is Chromodomain Y-like protein protein, from Human, contains 598 amino acids, locates in Nucleus.

Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the absence of the chromo domain (PubMed:19808672), Acts as a negative regulator of isoform 2 by displacing isoform 2 from chromatin


This is DNA polymerase eta protein, from Human, contains 713 amino acids, has 1 UBZ3-type Zinc finger, locates in Nucleus.

DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS) (PubMed:10385124, PubMed:11743006, PubMed:24449906, PubMed:24553286, PubMed:16357261), Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions, Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex, In the case of 1,2-intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (PubMed:24449906), Particularly important for the repair of UV-induced pyrimidine dimers (PubMed:10385124, PubMed:11743006), Although inserts the correct base, may cause base transitions and transversions depending upon the context, May play a role in hypermutation at immunoglobulin genes (PubMed:11376341, PubMed:14734526), Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have any lyase activity, preventing the release of the 5'-deoxyribose phosphate (5'-dRP) residue, This covalent trapping of the enzyme by the 5'-dRP residue inhibits its DNA synthetic activity during base excision repair, thereby avoiding high incidence of mutagenesis (PubMed:14630940), Targets POLI to replication foci (PubMed:12606586)

Belongs to the DNA polymerase type-Y family


This is PRELI domain-containing protein 1, mitochondrial protein, from Human, contains 219 amino acids, is soluble, locates in Mitochondrion.

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes, In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane, Regulates the mitochondrial apoptotic pathway in primary Th cells, Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number, May be important for the development of vital and immunocompetent organs


This is CAAX prenyl protease 2 protein, from Human, contains 329 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068)


This is Hepatocyte nuclear factor 3-beta protein, from Human, contains 457 amino acids, locates in Cytoplasm.

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues, Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites, Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity), In embryonic development is required for notochord formation, Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles, Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc, Interacts with the cis-acting regulatory regions of these genes, Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis, Involved in regulation of fat metabolism, Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation


This is Mitochondrial chaperone BCS1 protein, from Human, contains 419 amino acids, is membrane-bound, locates in Mitochondrion.

Chaperone necessary for the assembly of mitochondrial respiratory chain complex III, Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex

Belongs to the AAA ATPase family, BCS1 subfamily