This is Acidic phospholipase A2 protein, from Hundred-pace snake, contains 123 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that inhibits ADP-induced platelet aggregation, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is Elastase-1 protein, from Atlantic salmon, contains 236 amino acids, is soluble, locates in Extracellular.

Belongs to the peptidase S1 family, Elastase subfamily


This is Growth/differentiation factor 10 protein, from African clawed frog, contains 443 amino acids, is soluble, locates in Extracellular.

Dorsalizing factor, Antagonizes mesoderm formation by nodal-like proteins and ventralizing BMPs, Cooperates with cer1 to promote embryonic head formation


This is Serpin A12 protein, from Mouse, contains 413 amino acids, is soluble, locates in Extracellular.

Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues


This is E3 ubiquitin-protein ligase UHRF2 protein, from Mouse, contains 803 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger, locates in Nucleus.

PHD-type

RING-type

E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair, Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:23434322, PubMed:28402695), This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (PubMed:28115522), Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thus inducing G1 arrest, Ubiquitinates also PCNP leading to its degradation by the proteasome, Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation, Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor, Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation, Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (By similarity)


This is Protein Hook homolog 2 protein, from Mouse, contains 716 amino acids, is soluble, locates in Cytoplasm.

Component of the FTS/Hook/FHIP complex (FHF complex), The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex), Contributes to the establishment and maintenance of centrosome function, May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones, FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell


This is Stromal membrane-associated protein 2 protein, from Mouse, contains 428 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

GTPase activating protein that acts on ARF1, Can also activate ARF6 (in vitro), May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network


This is Serine incorporator 1 protein, from Rat, contains 453 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Enhances the incorporation of serine into phosphatidylserine and sphingolipids


This is Transcription factor RFX4 protein, from Mouse, contains 735 amino acids, locates in Nucleus.

Transcription factor that plays a role in early brain development, May activate transcription by interacting directly with the X-box, May activate transcription from CX3CL1 promoter through the X-box during brain development


This is Ammonium transporter Rh type C protein, from Rat, contains 497 amino acids, is membrane-bound, locates in Cell membrane.

Ammonium transporter involved in the maintenance of acid-base homeostasis, Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism, Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+), As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity), May act as a CO2 channel providing for renal acid secretion (By similarity)

Belongs to the ammonium transporter (TC 2,A,49) family, Rh subfamily


This is Protein DEK protein, from Mouse, contains 380 amino acids, locates in Nucleus.


This is Repulsive guidance molecule B protein, from Mouse, contains 436 amino acids, is membrane-bound, locates in Cell membrane.

Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system, Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling, Promotes neuronal adhesion, May inhibit neurite outgrowth (By similarity)

Belongs to the repulsive guidance molecule (RGM) family


This is Zinc finger protein ZIC 5 protein, from Mouse, contains 622 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 3 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate, Binds to DNA

Belongs to the GLI C2H2-type zinc-finger protein family


This is WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 protein, from Mouse, contains 571 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C2-type

Protease-inhibitor that contains multiple distinct protease inhibitor domains, Probably has serine protease- and metalloprotease-inhibitor activity (By similarity), Inhibits the biological activity of mature myostatin, but not activin


This is Tumor necrosis factor ligand superfamily member 18 protein, from Mouse, contains 173 amino acids, is membrane-bound, locates in Cell membrane.

Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196), Regulates T-cell responses (PubMed:14647196), Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759), Important for interactions between activated T-lymphocytes and endothelial cells, Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614), Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity), Promotes leukocyte adhesion to endothelial cells (PubMed:23892569), Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315)

Belongs to the tumor necrosis factor family


This is Refilin-A protein, from Mouse, contains 204 amino acids, is soluble, locates in Cytoplasm.

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins, Plays an essential role in the formation of cartilaginous skeletal elements


This is Hairy and enhancer of split-related protein HELT protein, from Mouse, contains 240 amino acids, locates in Nucleus.

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3', Required for the development of GABAergic neurons


This is Centrosomal protein of 120 kDa protein, from Mouse, contains 988 amino acids, is soluble, locates in Cytoplasm.

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome, Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development, Also implicated in the migration and selfrenewal of neural progenitors, Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis, Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity)


This is CMRF-35-like molecule 4 protein, from Mouse, contains 228 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Acts as an activating receptor in mast cells and macrophages


This is V-set domain containing T-cell activation inhibitor 1 protein, from Mouse, contains 283 amino acids, has 2 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like V-type

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity, When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity, Involved in promoting epithelial cell transformation

Belongs to the immunoglobulin superfamily, BTN/MOG family


This is Protein root UVB sensitive 1, chloroplastic protein, from Mouse-ear cress, contains 608 amino acids, is membrane-bound, locates in Plastid.

Involved in a root UV-B sensing pathway and in the protection against the hypersensitivity to very low-fluence-rate (VLF) UV-B, RSU1 and RUS2 are probably both negative modulators of the same UV-B perception pathway, which when overstimulated in the roots causes a block to postgermination development, Required for polar auxin transport by maintaining the proper levels of auxin transporters AUX1 (AC Q96247) and PIN proteins on the plasma membrane


This is PHD finger protein MALE MEIOCYTE DEATH 1 protein, from Mouse-ear cress, contains 704 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Probable transcription factor required for chromosome organization and progression during male meiosis (e,g, microsporogenesis) (PubMed:12782723, PubMed:14573517), Necessary for fertility and meiotic progressive compaction of prophase I chromosomes to metaphase I bivalents (PubMed:27385818), Together with JMJ16, promotes gene expression in male meiocytes in an H3K9me3-dependent manner, and contributes to meiotic chromosome condensation by triggering some condensin promoters (e,g, CAP-D3 and CAP-H) (PubMed:32572214, PubMed:27385818)


This is GCN5-related N-acetyltransferase 2, chloroplastic protein, from Mouse-ear cress, contains 258 amino acids, locates in Nucleus.

(Microbial infection) Required for begomovirus infection and systemic spread (PubMed:12837950, PubMed:15452236, PubMed:16461385), In case of begomoviruses infection, acetylates the capsid protein (CP), but not the nuclear shuttle protein (NSP) (PubMed:12837950, PubMed:15452236, PubMed:16461385), Stimulates melatonin-triggered defense responses to the necrotrophic Botrytis cinerea (PubMed:34234798)

Belongs to the acetyltransferase family, GNAT subfamily


This is F-box protein GID2 protein, from Rice, contains 212 amino acids, locates in Nucleus.

Essential component of some SCF-type E3 ligase complex that positively regulates the gibberellin signaling pathway, Upon gibberellin treatment, the complex mediates the ubiquitination and subsequent degradation of DELLA protein SLR1, a repressor of the gibberellin pathway, leading to activate the pathway


This is Dynein regulatory complex subunit 4 protein, from Chlamydomonas smithii, contains 471 amino acids, is soluble, locates in Cytoplasm.

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:12847082, PubMed:23427265, PubMed:25411337), Plays an important role in the assembly of the N-DRC linker (PubMed:23427265)


This is Xyloglucan galactosyltransferase MUR3 protein, from Mouse-ear cress, contains 619 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in the attachment of the Gal residue on the third xylosyl unit within the XXXG core structure of xyloglucan, the principal glycan that interlaces the cellulose microfibrils in plant cell wall (PubMed:12837954), Associates with other xyloglucan-synthesizing enzymes to form multiprotein complexes for xyloglucan synthesis in the Golgi (PubMed:25392066), Interacts with actin and is required for the proper endomembrane organization and for the cell elongation, Not involved in the trafficking from the endoplasmic reticulum to the vacuoles (PubMed:15863516), Involved in salt stress tolerance, Participates in the control of the expression of genes encoding for proteins involved in reactive oxygen species (ROS) detoxification under salt stress, May contribute to the maintenance of the proper organization of actin microfilaments during salt stress-induced ROS production (PubMed:23571490)

Belongs to the glycosyltransferase 47 family


This is Carotenoid cleavage dioxygenase 7, chloroplastic protein, from Mouse-ear cress, contains 618 amino acids, locates in Plastid.

Involved in strigolactones biosynthesis by cleaving asymmetrically a variety of linear and cyclic carotenoids at the 9-10 double bond, Produces one C(13) beta-ionone and the C(27) 10'-apo-beta-carotenal, Strigolactones are hormones that inhibit tillering and shoot branching through the MAX-dependent pathway, contribute to the regulation of shoot architectural response to phosphate-limiting conditions and function as rhizosphere signal that stimulates hyphal branching of arbuscular mycorrhizal fungi and trigger seed germination of root parasitic weeds, No activity on lycopene, lutein, zeaxanthin, violaxanthin or neoxanthin, Probably not involved in abscisic acid biosynthesis

Belongs to the carotenoid oxygenase family


This is Calcium-dependent protein kinase 16 protein, from Mouse-ear cress, contains 571 amino acids, is membrane-bound, locates in Cell membrane.

May play a role in signal transduction pathways that involve calcium as a second messenger

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDPK subfamily


This is Probable inactive receptor-like kinase BSK12 protein, from Mouse-ear cress, contains 465 amino acids, is membrane-bound, locates in Cell membrane.

Probable inactive protein kinase that activates the YODA MAP kinase cascade, which regulates the asymmetric first division and embryo polarity, by promoting the elongation of the zygote and the development of its basal daughter cell into the extra-embryonic suspensor, Acts as an adapter at the plasma membrane, possibly by recruiting and binding an activator

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Pachytene checkpoint protein 2 homolog protein, from Rice, contains 475 amino acids, locates in Nucleus.

Plays a key role in chromosome recombination during meiosis, Required for the initiation of meiotic recombination and the recruitment of PAIR2 onto meiotic chromosomes, Essential for meiotic DNA double-strand break (DSB) formation

Belongs to the AAA ATPase family, PCH2 subfamily


This is Mediator of RNA polymerase II transcription subunit 25 protein, from Mouse-ear cress, contains 836 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, Positive regulator of shade avoidance and of jasmonate signaling, Acts in repression of PhyB-mediated light signaling and regulates the expression of FLOWERING LOCUS T (FT) and of CONSTANS (CO)

Belongs to the Mediator complex subunit 25 family


This is Pentatricopeptide repeat-containing protein At3g57430, chloroplastic protein, from Mouse-ear cress, contains 890 amino acids, locates in Plastid.

Involved in RNA editing events in chloroplasts, Required for the editing of a single site in ndhB and ndhF transcripts, which are two plastid-encoded subunits of the chloroplast NAD(P)H dehydrogenase (NDH) complex, Required for the editing of a single site in psbZ, Required for optimal activity of the NDH complex of the photosynthetic electron transport chain

Belongs to the PPR family, PCMP-H subfamily


This is Glycine-rich selenoprotein protein, from Fruit fly, contains 110 amino acids, is membrane-bound, locates in Golgi apparatus.

Plays a role in the life span, May be involved in regulating the redox state of the cell and possesses anticarcinogenic properties


This is PTB-containing, cubilin and LRP1-interacting protein protein, from Human, contains 250 amino acids, is soluble, locates in Cytoplasm.

Increases proliferation of preadipocytes without affecting adipocytic differentiation


This is Transmembrane channel-like protein 6 protein, from Human, contains 805 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Peroxisome assembly protein 26 protein, from Human, contains 305 amino acids, is membrane-bound, locates in Peroxisome.

Peroxisomal docking factor that anchors PEX1 and PEX6 to peroxisome membranes (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970), PEX26 is therefore required for the formation of the PEX1-PEX6 AAA ATPase complex, a complex that mediates the extraction of the PEX5 receptor from peroxisomal membrane (PubMed:12717447, PubMed:12851857, PubMed:16854980, PubMed:21362118, PubMed:16763195, PubMed:16257970)


This is Potassium channel subfamily K member 18 protein, from Human, contains 384 amino acids, is membrane-bound, locates in Cell membrane.

Outward rectifying potassium channel, Produces rapidly activating outward rectifier K(+) currents, May function as background potassium channel that sets the resting membrane potential, Channel activity is directly activated by calcium signal, Activated by the G(q)-protein coupled receptor pathway, The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation, Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids, Channel activity is also enhanced by volatile anesthetics, such as isoflurane, Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper, May be involved in the somatosensory function with special respect to pain sensation (By similarity)

Belongs to the two pore domain potassium channel (TC 1,A,1,8) family


This is Cytochrome P450 2U1 protein, from Human, contains 544 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed:14660610, PubMed:24563460), Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:14660610, PubMed:24563460), Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids, May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed:14660610, PubMed:24563460), May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels, Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed:24563460)


This is HAUS augmin-like complex subunit 6 protein, from Human, contains 955 amino acids, is soluble, locates in Cytoplasm.

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex, Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin


This is Zinc finger protein 438 protein, from Human, contains 828 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

Isoform 1 acts as a transcriptional repressor

Belongs to the krueppel C2H2-type zinc-finger protein family


This is BRCA1-associated protein protein, from Human, contains 592 amino acids, has 1 RING-type Zinc finger, has 1 UBP-type; degenerate Zinc finger, is soluble, locates in Cytoplasm.

RING-type

UBP-type; degenerate

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein, Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation, May also act as a cytoplasmic retention protein with a role in regulating nuclear transport


This is Golgin subfamily A member 7 protein, from Human, contains 137 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in protein transport from Golgi to cell surface, The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS


This is DNA polymerase nu protein, from Human, contains 900 amino acids, locates in Nucleus.

DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template (PubMed:16787914, PubMed:17118716), Is the least accurate of the DNA polymerase A family (i,e, POLG, POLN and POLQ) (PubMed:17118716), Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol, Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template, Has no exonuclease activity (PubMed:16787914), Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence (PubMed:25775266), May play a role in TLS during interstrand cross-link (ICL) repair (PubMed:19908865), May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions, May function in the bypass of some DNA-protein and DNA-DNA cross-links, May have a role in cellular tolerance to DNA cross-linking agents (PubMed:20102227), Involved in the repair of DNA cross-links and double-strand break (DSB) resistance, Participates in FANCD2-mediated repair, Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904)

Belongs to the DNA polymerase type-A family


This is RNA 5'-monophosphate methyltransferase protein, from Human, contains 292 amino acids, is soluble, locates in Cytoplasm.

O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1 (PubMed:28119416, PubMed:31329584, PubMed:31919512), Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416), The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1 (PubMed:23063121), Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145 (PubMed:23063121, PubMed:28119416)

Belongs to the methyltransferase superfamily


This is Coiled-coil domain-containing protein 91 protein, from Human, contains 441 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in the regulation of membrane traffic through the trans-Golgi network (TGN), Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes


This is THAP domain-containing protein 5 protein, from Human, contains 395 amino acids, has 1 THAP-type Zinc finger, locates in Nucleus.

THAP-type

Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952), May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560)


This is Allergin-1 protein, from Human, contains 343 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells, Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)


This is Transcription termination factor 4, mitochondrial protein, from Human, contains 381 amino acids, locates in Mitochondrion.

Regulator of mitochondrial ribosome biogenesis and translation, Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S)


This is Endoglucanase-7 protein, from Trichoderma reesei, contains 249 amino acids, is soluble, locates in Extracellular.

Has low levels of endoglucanase activity, May be involved in the degradation of cellulose or lignocellulose, chitin, or other polysaccharides

Belongs to the glycosyl hydrolase 61 family


This is DNA replication complex GINS protein PSF2 protein, from African clawed frog, contains 185 amino acids, locates in Nucleus.

Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks, GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built


This is RNA binding protein fox-1 homolog 1-like protein, from Zebrafish, contains 382 amino acids, locates in Nucleus.

RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements, Regulates alternative splicing of tissue-specific exons


This is Membrane progestin receptor alpha-B protein, from Zebrafish, contains 354 amino acids, is membrane-bound, locates in Cell membrane.

Steroid membrane receptor, Signals upon progestin binding, resulting in rapid activation of MAPK and down-regulation of adenylyl cyclase activity, Interacts with steroids with varying degrees of affinity, showing specificity for activation by the maturation-inducing steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP), Capable of mediating progestin-induced oocyte maturation


This is Galactose-binding lectin l-1 protein, from Japanese eel, contains 142 amino acids, is soluble, locates in Extracellular.

Involved in host defense at the body surface, Causes agglutination of the Gram-positive bacterium S,difficile, Possesses calcium-independent hemagglutinating activity


This is Zygote arrest protein 1 protein, from Mouse, contains 361 amino acids, has 1 3CxxC-type Zinc finger, is soluble, locates in Cytoplasm.

mRNA-binding protein that mediates formation of MARDO (mitochondria-associated ribonucleoprotein domain), a membraneless compartment that stores maternal mRNAs in oocytes (PubMed:36264786), MARDO assembly around mitochondria is directed by an increase in mitochondrial membrane potential during oocyte growth (PubMed:36264786), Promotes formation of MARDO phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to maternal mRNAs (PubMed:36264786), Binds to the 3'-UTR of maternal mRNAs (PubMed:31598710), Maternal mRNAs stored in the MARDO are translationally repressed (PubMed:36264786), Essential for female fertility and oocyte-to-embryo transition by coordinating maternal mRNA storage, translation and degradation (PubMed:12539046, PubMed:31598710, PubMed:36264786)


This is Polycomb protein Suz12 protein, from Mouse, contains 741 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Polycomb group (PcG) protein, Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene, The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity), Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is Septin-9 protein, from Mouse, contains 583 amino acids, is soluble, locates in Cytoplasm.

Filament-forming cytoskeletal GTPase (By similarity), May play a role in cytokinesis (Potential)

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family


This is Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase protein, from Mouse, contains 356 amino acids, is membrane-bound, locates in Golgi apparatus.

Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate (PubMed:18695242), May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (PubMed:18695242), Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4

Belongs to the inositol monophosphatase superfamily


This is E3 ubiquitin-protein ligase TRIM56 protein, from Mouse, contains 734 amino acids, has 1 RING-type Zinc finger, has 2 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

B box-type

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21074459, PubMed:29426904), In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (PubMed:21074459), Also mediates monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904), Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling (By similarity), Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (By similarity)


This is Zinc finger and SCAN domain containing protein 4C protein, from Mouse, contains 506 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency, Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation, Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells


This is Protein KASH5 protein, from Mouse, contains 648 amino acids, is membrane-bound, locates in Nucleus.

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton, The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning, Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly, Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes, Essential for male and female gametogenesis, Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes, In oocytes is involved in meiotic resumption and spindle formation


This is RNA polymerase II elongation factor ELL3 protein, from Mouse, contains 395 amino acids, locates in Nucleus.

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification, Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA, Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III, Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner, Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation, Required for recruitment of P-TEFb within SEC during differentiation, Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells, Promoting epithelial-mesenchymal transition (EMT)


This is Sulfotransferase 1C1 protein, from Mouse, contains 304 amino acids, is soluble, locates in Cytoplasm.

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters, May be involved in the activation of carcinogenic hydroxylamines, Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF), Also shows activity towards cinnamyl alcohol at pH 6,4 but not at pH 5,5, and towards a number of phenolic odorants including eugenol, guaiacol and 2-naphthol

Belongs to the sulfotransferase 1 family


This is ATP-dependent RNA helicase DHX33 protein, from Mouse, contains 698 amino acids, locates in Nucleus.

Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779), Stimulates RNA polymerase I transcription of the 47S precursor rRNA, Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779), In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019), Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (By similarity), Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (By similarity), In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (PubMed:24037184)

Belongs to the DEAD box helicase family, DEAH subfamily


This is Nucleoplasmin-2 protein, from Mouse, contains 207 amino acids, locates in Nucleus.

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development, Probably involved in sperm DNA decondensation during fertilization


This is 2-acylglycerol O-acyltransferase 2 protein, from Mouse, contains 334 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA, Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0, Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes, May play a role in diet-induced obesity, Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity)

Belongs to the diacylglycerol acyltransferase family


This is Organic solute transporter subunit beta protein, from Mouse, contains 128 amino acids, is membrane-bound, locates in Cell membrane.

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:15563450, PubMed:16317684, PubMed:17650074, PubMed:22535958), The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:17650074, PubMed:22535958), Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (PubMed:16317684), Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity), Able to transport eicosanoids such as prostaglandin E2 (By similarity), Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:15563450)


This is Inactive rhomboid protein 2 protein, from Mouse, contains 827 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation, Does not exhibit any protease activity on its own


This is Beta-citrylglutamate synthase B protein, from Mouse, contains 387 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate, Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate


This is Interleukin-22 receptor subunit alpha-2 protein, from Mouse, contains 230 amino acids, is soluble, locates in Extracellular.

Receptor for IL22, Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro), May play an important role as an IL22 antagonist in the regulation of inflammatory responses

Belongs to the type II cytokine receptor family


This is Inositol-trisphosphate 3-kinase C protein, from Rat, contains 678 amino acids, locates in Cytoplasm.

Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:12649294), Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate

Belongs to the inositol phosphokinase (IPK) family


This is TMF-regulated nuclear protein 1 protein, from Mouse, contains 223 amino acids, locates in Nucleus.

DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex, Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification, May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points


This is Protein Abitram protein, from Mouse, contains 193 amino acids, locates in Nucleus.

Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons


This is Calcium uniporter regulatory subunit MCUb, mitochondrial protein, from Mouse, contains 345 amino acids, is membrane-bound, locates in Mitochondrion.

Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion, Does not form functional calcium channels by itself, Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways


This is Guanine nucleotide-binding protein-like 3 protein, from Rat, contains 538 amino acids, locates in Nucleus.

May be required to maintain the proliferative capacity of stem cells, Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity)

Belongs to the TRAFAC class YlqF/YawG GTPase family


This is Cytoplasmic polyadenylation element-binding protein 2 protein, from Mouse, contains 521 amino acids, is soluble, locates in Cytoplasm.

May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids, Binds to poly(U) RNA oligomers (PubMed:12672660), Required for cell cycle progression, specifically for the transition from metaphase to anaphase (By similarity)


This is Gibberellin-regulated protein 5 protein, from Mouse-ear cress, contains 97 amino acids, is soluble, locates in Extracellular.

Gibberellin-regulated protein that acts as a negative regulator of gibberellin-induced flowering and stem growth, May inhibit flowering and inflorescence growth via a pathway involving GAI and by enhancing FLC expression and repressing FT and LFY, Acts as a negative regulator in thermotolerance by resogulating both salicylic acid (SA) signaling and heat shock-protein accumulation


This is Polynucleotide 3'-phosphatase ZDP protein, from Mouse-ear cress, contains 694 amino acids, has 3 PARP-type Zinc finger, is soluble, locates in Nucleus.

PARP-type

PARP-type

PARP-type

Nick-sensing 3'-phosphoesterase involved in a base excision repair pathway required for active DNA demethylation, The N-terminal DNA-binding domain binds specifically to gap sites and sharply bends the target DNA, Lacks 5'-kinase activity but is capable of 3'-phosphoglycolate end processing, Inactive on 3'-alpha,beta-unsaturated aldehyde (3'-dRP), Protects partially genes from transcriptional silencing by preventing promoter DNA hypermethylation

In the C-terminal section; belongs to the DNA 3' phosphatase family


This is Adenylyl-sulfate kinase 4, chloroplastic protein, from Mouse-ear cress, contains 310 amino acids, locates in Plastid.

Catalyzes the phosphorylation of adenosine 5'-phosphosulfate to 3'-phosphoadenylyl sulfate, which is the activated sulfate form for sulfation reactions, Essential for plant reproduction and viability


This is Protein PLASTID TRANSCRIPTIONALLY ACTIVE 14 protein, from Mouse-ear cress, contains 483 amino acids, locates in Plastid.

Essential for chloroplast development, especially for thylakoid formation, Involved in plastid gene expression, probably by maintaining plastid-encoded RNA polymerase (PEP) activity

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is SWI/SNF complex subunit SWI3B protein, from Mouse-ear cress, contains 469 amino acids, locates in Nucleus.

Component of a multiprotein complex equivalent of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors, May play an essential role in the transition from the vegetative to the reproductive phase of development, May be a positive regulator of ABA signaling


This is Large ribosomal subunit protein uL14my protein, from Mouse-ear cress, contains 196 amino acids, locates in Mitochondrion.

Binds to 23S rRNA in mitochondrion (By similarity), Required for the formation of the proximal region of the ovule primordium during floral organogenesis, thus participating in patterning and growth of ovule, Also regulates the initiation and/or maintenance of integument and embryo sac ontogenesis, Prevents inappropriate cell death in the young ovule

Belongs to the universal ribosomal protein uL14 family


This is Protein FD protein, from Mouse-ear cress, contains 285 amino acids, locates in Nucleus.

Transcription factor required for the transition to flowering promoted by FT


This is Pollen receptor-like kinase 2 protein, from Mouse-ear cress, contains 647 amino acids, is membrane-bound, locates in Cell membrane.

Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth (PubMed:23024212, PubMed:24136420), Phosphorylates ROPGEF1 in its C-terminal region, releasing its auto-inhibition, and thereby activating the ROP1 signaling pathway (PubMed:23024212), May act as a scaffolding protein, recruiting ROPGEF12 to the plasma membrane by binding to its C-terminal domain (PubMed:18000057), Phosphorylates ROPGEF12, releasing its auto-inhibition (PubMed:18000057)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Protein-tyrosine-phosphatase IBR5 protein, from Mouse-ear cress, contains 257 amino acids, locates in Nucleus.

Required for the transduction of auxin and abscisic acid (ABA) signaling pathways, Dephosphorylates and inactivates the MAP kinase MPK12

Belongs to the protein-tyrosine phosphatase family


This is Peroxisomal membrane protein 11E protein, from Mouse-ear cress, contains 231 amino acids, is membrane-bound, locates in Peroxisome.

Involved in peroxisomal proliferation, Promotes peroxisomal duplication, aggregation or elongation without fission


This is UDP-sulfoquinovose synthase, chloroplastic protein, from Spinach, contains 482 amino acids, is soluble, locates in Plastid.

Involved in the biosynthesis of sulfolipids found in thylakoid membranes, Converts UDP-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose, The sulfite is delivered to the reaction center by the FMN-binding domain of FdGOGAT

Belongs to the NAD(P)-dependent epimerase/dehydratase family


This is Rhomboid-like protein 11, chloroplastic protein, from Mouse-ear cress, contains 280 amino acids, is membrane-bound, locates in Plastid.

Rhomboid-type serine protease that catalyzes intramembrane proteolysis, May be involved in TIC22 processing during its import


This is Transcription factor IIIA protein, from Mouse-ear cress, contains 412 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 5 C2H2-type Zinc finger, has 1 C2H2-type 6; degenerate Zinc finger, has 1 C2H2-type 7; degenerate Zinc finger, has 1 C2H2-type 9; degenerate Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 6; degenerate

C2H2-type 7; degenerate

C2H2-type 9; degenerate

Essential protein (PubMed:22353599), Isoform 1 is a transcription activator the binds both 5S rDNA and 5S rRNA and stimulates the transcription of 5S rRNA gene (PubMed:12711688, PubMed:22353599), Isoform 1 regulates 5S rRNA levels during development (PubMed:22353599)


This is Peroxisomal OPC-8:0-CoA ligase 1 protein, from Mouse-ear cress, contains 546 amino acids, locates in Peroxisome.

Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors (PubMed:16963437, PubMed:18267944), Converts 12-oxo-phytodienoic acid (OPDA) and 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid (OPC-8:0) into OPDA-CoA and OPC-8:0-CoA, respectively (PubMed:16963437, PubMed:18267944), Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity)

Belongs to the ATP-dependent AMP-binding enzyme family


This is 4-coumarate--CoA ligase-like 9 protein, from Mouse-ear cress, contains 562 amino acids, locates in Peroxisome.

Contributes to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors (PubMed:15677481, PubMed:18267944), Converts 12-oxo-phytodienoic acid (OPDA) into OPDA-CoA (PubMed:15677481, PubMed:18267944), Follows a two-step reaction mechanism, wherein the carboxylate substrate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield the final CoA thioester (By similarity)


This is Probable GTP diphosphokinase CRSH, chloroplastic protein, from Mouse-ear cress, contains 583 amino acids, locates in Plastid.

Possesses calcium-dependent ppGpp (guanosine 3'-diphosphate 5'-diphosphate) synthetase activity in vitro and is able to functionally complement E,coli relA mutants, Plays an important role in the timing adjustment of pistil and pollen maturation required for successful pollination, May be involved in a rapid plant ppGpp-mediated response to pathogens and other stresses


This is Chlorophyll(ide) b reductase NOL, chloroplastic protein, from Rice, contains 343 amino acids, is membrane-bound, locates in Plastid.

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Protein phosphatase 2C 35 protein, from Rice, contains 639 amino acids, is membrane-bound, locates in Cell membrane.

Protein phosphatase that acts on XA21 pathogen recognition receptor, Negatively regulates cell death and XA21-mediated innate immunity


This is DIBOA-glucoside dioxygenase BX6 protein, from Maize, contains 374 amino acids, is soluble, locates in Cytoplasm.

2-oxoglutarate-dependent dioxygenase required for hydroxylation in position C-7 of the benzoxazinoids, Can use 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside (DIBOA-glucoside) as substrate, but not aglucone DIBOA

Belongs to the iron/ascorbate-dependent oxidoreductase family


This is E3 ubiquitin-protein ligase PUB23 protein, from Mouse-ear cress, contains 411 amino acids, is soluble, locates in Cytoplasm.

E3 ubiquitin-protein ligase that negatively regulates water stress response, May control in coordination with PUB23 a drought signaling pathway by ubiquitinating cytosolic RPN12a, Acts as negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB22 and PUB24


This is Protein NLP7 protein, from Mouse-ear cress, contains 959 amino acids, locates in Nucleus.

Transcription factor involved in regulation of nitrate assimilation and in transduction of the nitrate signal


This is Bifunctional monodehydroascorbate reductase and carbonic anhydrase nectarin-3 protein, from Ornamental tobacco, contains 274 amino acids, is soluble, locates in Extracellular.

Bifunctional enzyme which has both carbonate dehydratase and monodehydroascorbate reductase activities, May be involved in regulation of nectar pH, May also regulate nectar ascorbate concentration, protecting floral tissues from free radical damage

Belongs to the alpha-carbonic anhydrase family


This is Phosphatidylserine decarboxylase proenzyme 1, mitochondrial protein, from Mouse-ear cress, contains 453 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer), Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine, Contributes only to a minor proportion of PtdEtn production

Belongs to the phosphatidylserine decarboxylase family, PSD-B subfamily, Eukaryotic type I sub-subfamily


This is CBL-interacting serine/threonine-protein kinase 26 protein, from Mouse-ear cress, contains 439 amino acids, is membrane-bound, locates in Cell membrane.

CIPK serine-threonine protein kinases interact with CBL proteins, Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner, Involved in the calcium-dependent regulation of reactive oxygen species production by the NADPH oxidase RBOHF

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is CLAVATA3/ESR (CLE)-related protein 41 protein, from Mouse-ear cress, contains 99 amino acids, is soluble, locates in Extracellular.

Extracellular signal peptide that regulates cell fate, May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins in an auxin-dependent manner, Regulates the transition of protophloem cells from proliferation to differentiation, thus impinging on postembryonic growth capacity of the root meristem; this signaling pathway requires CRN and CLV2 (PubMed:28607033)

Belongs to the CLV3/ESR signal peptide family


This is Bidirectional sugar transporter SWEET17 protein, from Mouse-ear cress, contains 241 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Acts as a vacuolar hexose transporter (PubMed:25988582), Regulates fructose (Fru) homeostasis in leaves and roots by exporting/importing Fru through the tonoplast regarding metabolic demand (PubMed:23583552, PubMed:24381066)

Belongs to the SWEET sugar transporter family


This is Transcription factor GTE1 protein, from Mouse-ear cress, contains 386 amino acids, locates in Nucleus.

Transcription activator that plays a role in the promotion of seed germination by both negatively and positively regulating the abscisic acid (ABA) and phytochrome A (phyA) transduction pathways, respectively


This is Monothiol glutaredoxin-S14, chloroplastic protein, from Mouse-ear cress, contains 173 amino acids, locates in Plastid.

May only reduce GSH-thiol disulfides, but not protein disulfides (Potential), Probably involved in the regulation of the redox state of the BOLA proteins (Potential), May act as Fe-S cluster donors to Fe-S cluster-requiring proteins (PubMed:18044966), May protect cells against protein oxidative damage (PubMed:16829529), May regulate CAX cation transporters (PubMed:16829529), The GRXS14-BOLA1 heterodimer binds a labile, oxygen sensitive Fe-S cluster (PubMed:24714563)

Belongs to the glutaredoxin family, CGFS subfamily


This is Two pore potassium channel a protein, from Rice, contains 347 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Highly selective inward-rectifying potassium channel that is specifically located in the tonoplast of large vacuoles, Functions independently of the voltage difference across the membrane

Belongs to the two pore domain potassium channel (TC 1,A,1,7) family


This is Poly(ADP-ribose) glycohydrolase 1 protein, from Caenorhabditis elegans, contains 781 amino acids, locates in Nucleus.

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:17188026), Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells (By similarity)

Belongs to the poly(ADP-ribose) glycohydrolase family


This is Longitudinals lacking protein, isoforms F/I/K/T protein, from Fruit fly, contains 970 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

Putative transcription factor required for axon growth and guidance in the central and peripheral nervous systems, Repels CNS axons away from the midline by promoting the expression of the midline repellent sli and its receptor robo


This is Prolyl endopeptidase protein, from Social amoeba, contains 760 amino acids, is soluble, locates in Cytoplasm.

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long


This is Stress-activated protein kinase alpha protein, from Social amoeba, contains 638 amino acids, is soluble, locates in Cytoplasm.

May be involved in cortical F-actin organization and resistance to osmotic stress, Activated upon cell detachment, in vitro

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family


This is Modifier of mdg4 protein, from Fruit fly, contains 610 amino acids, has 1 FLYWCH-type Zinc finger, locates in Nucleus.

FLYWCH-type

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators, Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes, Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV), Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops, This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery, Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional, Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents, Isoform H also plays a role in apoptotic regulatory pathways


This is Heparan sulfate 2-O-sulfotransferase pipe protein, from Fruit fly, contains 514 amino acids, is membrane-bound, locates in Golgi apparatus.

Sulfotransferase involved in dorsoventral axis patterning in early embryos, Required for the specific ventral activation of a series of proteases acting in the perivitelline space between the embryonic membrane and the eggshell, Probably acts by mediating the sulfation of some glycoprotein or glycosaminoglycan stably deposited in the egg, whose ventrally localized modification leads to spatially restricted activation of the protease cascade

Belongs to the sulfotransferase 3 family


This is Vanadium-binding protein 2 protein, from Vanadium-rich ascidian, contains 120 amino acids, is soluble, locates in Cytoplasm.

Acts as a vanadium reductase which may form an electron transfer cascade in conjunction with NADPH and glutathione through thiol disulfide exchange reactions, Partial cleavage of its disulfide bonds results in the reduction of V(5+) to V(4+), Binds up to 24 V(4+) ions per protein at pH 7,5, Also binds Fe(3+) and Cu(2+) and, to a lesser extent, Co(2+), Zn(2+) and Ni(2+)


This is Mu-conotoxin SIIIA protein, from Striated cone, contains 73 amino acids, is soluble, locates in Extracellular.

Mu-conotoxins block voltage-gated sodium channels (Nav), This toxin moderately blocks rNav1,1/SCN1A, rNav1,2/SCN2A, rNav1,3/SCN3A, rNav1,4/SCN4A, and mNav1,6/SCN8A


This is Potassium channel toxin gamma-KTx 1.1 protein, from Mexican scorpion, contains 62 amino acids, is soluble, locates in Extracellular.

Blocks human and rat Kv11,1/KCNH2/ERG1 and Kv11,3/KCNH7/ERG3, as well as rat (but not human) Kv11,2/KCNH6/ERG2 (PubMed:11755529, PubMed:11864985, PubMed:16497878, PubMed:17369411, PubMed:20600425) by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry (PubMed:11755529, PubMed:11864985, PubMed:17369411, PubMed:20600425), Inhibition data are the following: hERG1 (reversible, IC(50)~7 nM) (PubMed:11755529, PubMed:11864985, PubMed:16497878, PubMed:17369411, PubMed:20600425), rERG1 (reversible, Kd=6,8 nM) (PubMed:16497878), rERG2 (irreversible, Kd=2,8 nM) (PubMed:16497878), hERG3 (irreversible, Kd=4,05 nM) (PubMed:16497878) and rERG3 (reversible, Kd=38,1 nM) (PubMed:16497878) potassium channels, The toxin potency is not affected by elevating potassium ion concentration from 2 to 98 mM (PubMed:11864985), This toxin only blocks channels in a closed state (PubMed:12860380), At high toxin concentrations, block of Kv11,1/KCNH2/ERG1 macroscopic current is incomplete (93,5%), This suggests a kinetic mechanism model with two different states of toxin-channel binding (T+C=TC*=TC; in the TC* state, the toxin binds the channel but does not occlude the pore, whereas in the TC state the toxin binds and occludes the pore), In this model, incomplete block is explained by the relatively fast dissociation rate from the blocked channel conformation (TC) relative to the rate of conversion of the toxin-channel encounter complex (TC*) to the blocked channel conformation (TC) (PubMed:17369411)

Belongs to the ergtoxin family, Gamma-KTx 1 subfamily


This is Polycomb group RING finger protein 5 protein, from Human, contains 256 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332), Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332), Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity)


This is Stearoyl-CoA desaturase 5 protein, from Human, contains 330 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates, Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828), Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797), Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828)

Belongs to the fatty acid desaturase type 1 family


This is Dehydrodolichyl diphosphate synthase complex subunit DHDDS protein, from Human, contains 333 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery, Both subunits contribute to enzymatic activity, i,e, condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466), Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466), Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394)


This is Glutaredoxin-related protein 5, mitochondrial protein, from Human, contains 157 amino acids, is soluble, locates in Mitochondrion.

Monothiol glutaredoxin involved in mitochondrial iron-sulfur (Fe/S) cluster transfer (PubMed:20364084, PubMed:23615440), Receives 2Fe/2S clusters from scaffold protein ISCU and mediates their transfer to apoproteins, to the 4Fe/FS cluster biosynthesis machinery, or export from mitochondrion (PubMed:20364084, PubMed:23615440, PubMed:24334290), Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084)

Belongs to the glutaredoxin family, Monothiol subfamily


This is Transmembrane protein 150A protein, from Human, contains 271 amino acids, is membrane-bound, locates in Cell membrane.

Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex (PubMed:25608530), Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530), May also play a role in fasting-induced catabolism (By similarity)


This is Store-operated calcium entry regulator STIMATE protein, from Human, contains 294 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574), SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679), Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679), Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574), Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574)


This is Probable ATP-dependent RNA helicase DDX53 protein, from Human, contains 631 amino acids, locates in Nucleus.


This is E3 ubiquitin-protein ligase synoviolin protein, from Human, contains 617 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28827405), Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130, PubMed:28842558), Also promotes the degradation of normal but naturally short-lived proteins such as SGK, Protects cells from ER stress-induced apoptosis, Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218), Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702), Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity), During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity)


This is Acyl-coenzyme A thioesterase 1 protein, from Human, contains 421 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels, More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20)

Belongs to the C/M/P thioester hydrolase family


This is Iron-sulfur cluster assembly 2 homolog, mitochondrial protein, from Human, contains 154 amino acids, locates in Mitochondrion.

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway, May be involved in the binding of an intermediate of Fe/S cluster assembly


This is N6-adenosine-methyltransferase catalytic subunit protein, from Human, contains 580 amino acids, locates in Nucleus.

The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:28297716, PubMed:30428350, PubMed:29506078, PubMed:29348140, PubMed:9409616), In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194), N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:28297716, PubMed:9409616), M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation (PubMed:28637692), In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity), M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity), M6A also regulates circadian regulation of hepatic lipid metabolism (PubMed:30428350), M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity), Also required for oogenesis (By similarity), Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites (PubMed:28297716), M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation (By similarity), Inhibits the type I interferon response by mediating m6A methylation of IFNB (PubMed:30559377), M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998), Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist (PubMed:27602518), M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity), METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998), Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702), Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation (PubMed:27117702), During human coronorivus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses (PubMed:33961823)


This is Glycerol-3-phosphate acyltransferase 4 protein, from Human, contains 456 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:18238778), Active against both saturated and unsaturated long-chain fatty acyl-CoAs (PubMed:18238778), Protects cells against lipotoxicity (PubMed:30846318)

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is Reticulon-4 receptor-like 1 protein, from Human, contains 441 amino acids, is membrane-bound, locates in Cell membrane.

Cell surface receptor, Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system, Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum, Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG, Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans, Binds heparin (By similarity), Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200), Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200)


This is Zinc finger protein 589 protein, from Human, contains 364 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

May play a role in hematopoietic stem/progenitor cell differentiation, May play a role as a DNA binding-dependent transcriptional repressor

Belongs to the krueppel C2H2-type zinc-finger protein family


This is NLR family member X1 protein, from Human, contains 975 amino acids, is membrane-bound, locates in Mitochondrion.

Participates in antiviral signaling, Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010), Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352), Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910), Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313), Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (By similarity), In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (By similarity)


This is Organic solute transporter subunit beta protein, from Human, contains 128 amino acids, is membrane-bound, locates in Cell membrane.

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684), Modulates SLC51A glycosylation, membrane trafficking and stability activities (PubMed:16317684), The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684), Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity), Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684), Able to transport eicosanoids such as prostaglandin E2 (By similarity)


This is Adiponectin receptor protein 2 protein, from Human, contains 386 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295), Required for normal body fat and glucose homeostasis, ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake, Has intermediate affinity for globular and full-length adiponectin, Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity)


This is Tubulinyl-Tyr carboxypeptidase 2 protein, from Human, contains 355 amino acids, is soluble, locates in Extracellular.

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869), Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830), Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325), Plays a role in axon formation (PubMed:31235911)

Belongs to the transglutaminase-like superfamily, Vasohibin family


This is Metalloprotease TIKI1 protein, from Human, contains 505 amino acids, is membrane-bound, locates in Cell membrane.

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins, Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation, Able to cleave WNT3A, WNT5, but not WNT11, Required for head formation


This is Serine/threonine-protein kinase pim-3 protein, from Human, contains 326 amino acids, is soluble, locates in Cytoplasm.

Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation, May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity, Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6, Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily


This is Lebercilin protein, from Human, contains 697 amino acids, is soluble, locates in Cytoplasm.

Involved in intraflagellar protein (IFT) transport in photoreceptor cilia


This is Thioredoxin domain-containing protein 2 protein, from Human, contains 553 amino acids, is soluble, locates in Cytoplasm.

Probably plays a regulatory role in sperm development, May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis, May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents, Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase


This is Phosphatidylcholine:ceramide cholinephosphotransferase 1 protein, from Human, contains 413 amino acids, is membrane-bound, locates in Golgi apparatus.

Major sphingomyelin synthase at the Golgi apparatus (PubMed:17449912, PubMed:14685263), Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER, The direction of the reaction depends on the levels of CER and DAG in Golgi membranes (PubMed:14685263, PubMed:17449912, PubMed:14976195, PubMed:17982138, PubMed:19454763), Does not use free phosphorylcholine or CDP-choline as donor (PubMed:14976195, PubMed:14685263), Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:14976195, PubMed:17449912, PubMed:17982138), Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (PubMed:18370930, PubMed:21980337)

Belongs to the sphingomyelin synthase family


This is Juxtaposed with another zinc finger protein 1 protein, from Human, contains 243 amino acids, has 2 C2H2-type Zinc finger, has 1 C2H2-type 3; degenerate Zinc finger, locates in Nucleus.

C2H2-type 3; degenerate

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918), Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity), Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity), Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity), Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity)


This is Cytochrome P450 4Z1 protein, from Human, contains 505 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase that catalyzes the in-chain oxidation of fatty acids (PubMed:19090726, PubMed:29018033), Catalyzes the hydroxylation of carbon-hydrogen bonds, Hydroxylates lauric and myristic acids predominantly at the omega-4 and omega-2 positions, respectively (PubMed:19090726, PubMed:29018033), Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA), Displays an absolute stereoselectivity in the epoxidation of arachidonic acid producing the 14(S),15(R)-epoxyeicosatrienoic acid (EET) enantiomer (PubMed:29018033), Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:19090726, PubMed:29018033)


This is THO complex subunit 6 homolog protein, from Human, contains 341 amino acids, locates in Nucleus.

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA, TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway, The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production, Plays a role in apoptosis negative control involved in brain development


This is Lon protease homolog 2, peroxisomal protein, from Human, contains 852 amino acids, is soluble, locates in Peroxisome.

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix, Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity), May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1


This is Zinc finger C3HC-type protein 1 protein, from Human, contains 502 amino acids, has 1 C3HC-type Zinc finger, locates in Nucleus.

Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1), Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase, Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry, May have an antiapoptotic role in NPM-ALK-mediated signaling events


This is Protein unc-93 homolog A protein, from Human, contains 457 amino acids, is membrane-bound, locates in Cell membrane.


This is Osteopetrosis-associated transmembrane protein 1 protein, from Human, contains 334 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for osteoclast and melanocyte maturation and function


This is Ras association domain-containing protein 3 protein, from Human, contains 238 amino acids, is soluble, locates in Cytoplasm.


This is Chromodomain-helicase-DNA-binding protein 1-like protein, from Human, contains 897 amino acids, locates in Nucleus.

ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34486521, PubMed:34874266, PubMed:34210977), Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521), Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521), Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653), Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888)

Belongs to the SNF2/RAD54 helicase family


This is Nuclear receptor 2C2-associated protein protein, from Human, contains 139 amino acids, locates in Nucleus.

May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes


This is Active regulator of SIRT1 protein, from Human, contains 136 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome, Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed:34516797), Direct regulator of SIRT1, Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed:17964266)


This is Dihydrofolate reductase 2, mitochondrial protein, from Human, contains 187 amino acids, is membrane-bound, locates in Mitochondrion.

Key enzyme in folate metabolism, Contributes to the de novo mitochondrial thymidylate biosynthesis pathway, Required to prevent uracil accumulation in mtDNA, Binds its own mRNA and that of DHFR

Belongs to the dihydrofolate reductase family


This is GAS2-like protein 3 protein, from Human, contains 694 amino acids, is soluble, locates in Cytoplasm.

Cytoskeletal linker protein, May promote and stabilize the formation of the actin and microtubule network


This is Swi5-dependent recombination DNA repair protein 1 homolog protein, from Human, contains 245 amino acids, locates in Nucleus.

Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination (PubMed:21252223), Acts as a transcriptional modulator for ESR1 (PubMed:23874500)


This is Ankyrin repeat and LEM domain-containing protein 2 protein, from Human, contains 938 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit (PubMed:22770216), Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly (PubMed:22770216), May regulate nuclear localization of VRK1 in non-dividing cells (PubMed:31735666), It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (PubMed:22770216), Involved in brain development (PubMed:25259927)


This is E3 ubiquitin-protein ligase TRIM50 protein, from Human, contains 487 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308), In turn, promotes starvation-induced autophagy activation, Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322), Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity)


This is ERO1-like protein beta protein, from Human, contains 467 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum, Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation, Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10%), Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell, May be involved in oxidative proinsulin folding in pancreatic cells, hence may play a role in glucose homeostasis


This is Transcriptional repressor p66-alpha protein, from Human, contains 633 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Transcriptional repressor (PubMed:12183469, PubMed:16415179), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666), Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179), Efficient repression requires the presence of GATAD2B (PubMed:16415179)


This is Endochitinase B1 protein, from Neosartorya fumigata, contains 433 amino acids, is soluble, locates in Extracellular.

Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods), Plays a role in the morphogenesis and autolysis (By similarity)

Belongs to the glycosyl hydrolase 18 family, Chitinase class V subfamily


This is Acidic phospholipase A2 BthA-1 protein, from Jararacussu, contains 138 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) that displays edema-inducing activities (activity that is inhibited by EDTA and dexamethasone), inhibits phospholipid-dependent collagen/ADP-induced platelet aggregation, possess hypotensive as well as anticoagulant activities, In addition, this enzyme shows bactericidal activity against E,coli and S,aureus, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is Thrombin-like enzyme stejnobin protein, from Chinese green tree viper, contains 260 amino acids, is soluble, locates in Extracellular.

Thrombin-like snake venom serine protease that has fibrinogen-clotting activity (FGA or FGB)

Belongs to the peptidase S1 family, Snake venom subfamily


This is R-spondin-2 protein, from Mouse, contains 243 amino acids, is soluble, locates in Extracellular.

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes, Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway, Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646), During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity)


This is Doublesex- and mab-3-related transcription factor 2 protein, from Mouse, contains 561 amino acids, locates in Nucleus.

Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it, Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome, Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome, Is not required for sex determination and/or differentiation in embryonic development, Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left-right asymmetric organ positioning


This is Prostaglandin reductase-3 protein, from Mouse, contains 377 amino acids, locates in Peroxisome.

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha, Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation

Belongs to the zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily


This is Neuronal PAS domain-containing protein 4 protein, from Mouse, contains 802 amino acids, locates in Nucleus.

Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:24855953), Plays a key role in the structural and functional plasticity of neurons (PubMed:23172225), Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (PubMed:24201284, PubMed:24855953), In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (PubMed:18815592, PubMed:22194569, PubMed:24201284), In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (PubMed:24855953), The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:27238022), Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (PubMed:25088421), Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734, PubMed:15363889, PubMed:19284974), Can activate the CME (CNS midline enhancer) element (PubMed:14701734, PubMed:15363889)


This is Tripartite motif-containing protein 6 protein, from Mouse, contains 488 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

E3 ubiquitin ligase that plays a crucial role in the activation of the IKBKE-dependent branch of the type I interferon signaling pathway (PubMed:24882218), In concert with the ubiquitin-conjugating E2 enzyme UBE2K, synthesizes unanchored 'Lys-48'-linked polyubiquitin chains that promote the oligomerization and autophosphorylation of IKBKE leading to stimulation of an antiviral response (PubMed:24882218), Ubiquitinates also MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (PubMed:22328504), Promotes the association of unanchored 'Lys-48'-polyubiquitin chains with DHX16 leading to enhancement of RIGI-mediated innate antiviral immune response (By similarity)


This is Cysteine/serine-rich nuclear protein 2 protein, from Mouse, contains 534 amino acids, locates in Nucleus.

Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity, May play a role in apoptosis


This is Osteopetrosis-associated transmembrane protein 1 protein, from Mouse, contains 338 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Required for osteoclast and melanocyte maturation and function


This is Cerebellin-2 protein, from Mouse, contains 224 amino acids, is soluble, locates in Extracellular.

Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:29691328, PubMed:21410790), Essential for long-term maintenance but not establishment of excitatory synapses (PubMed:29691328, PubMed:30287486)