This is Ferulic acid decarboxylase 1 protein, from Baker's yeast, contains 503 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites (PubMed:20471595, PubMed:25647642), Not essential for ubiquinone synthesis (PubMed:20471595)

Belongs to the UbiD family, UbiD-like/FDC subfamily


This is Monocarboxylate transporter 1 protein, from Long-tailed dwarf hamster, contains 494 amino acids, is membrane-bound, locates in Cell membrane.

Bidirectional proton-coupled monocarboxylate transporter, Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (By similarity), The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate, MCT1 is a major lactate exporter (PubMed:1429658), Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity), Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart, Functions via alternate outward- and inward-open conformation states, Protonation and deprotonation of 302-Asp is essential for the conformational transition (By similarity)

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is SAGA-associated factor 11 protein, from Baker's yeast, contains 99 amino acids, has 1 SGF11-type Zinc finger, locates in Nucleus.

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SGF11 is involved in transcriptional regulation of a subset of SAGA-regulated genes, Within the SAGA complex, participates in a subcomplex with SUS1, SGF73 and UBP8 required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels, It is required to recruit UBP8 and SUS1 into the SAGA complex


This is Endoplasmic oxidoreductin-1 protein, from Baker's yeast, contains 563 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds, Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange, Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent, Also able to oxidize directly the PDI related protein MPD2, Does not oxidize all PDI related proteins, suggesting that it can discriminate between PDI1 and related proteins, Reoxidation of ERO1 probably involves electron transfer to molecular oxygen via FAD, Acts independently of glutathione, May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress


This is Chromatin structure-remodeling complex subunit RSC9 protein, from Baker's yeast, contains 581 amino acids, locates in Nucleus.

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit plays a role in transcriptional response to stress, It is involved in both repression and activation of mRNAs regulated by the target of rapamycin (TOR) kinases, and in the synthesis of rRNA


This is Centromere protein C protein, from Human, contains 943 amino acids, locates in Nucleus.

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation, The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres, CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions


This is Translation initiation factor RLI1 protein, from Baker's yeast, contains 608 amino acids, locates in Cytoplasm.

Component of the multifactor complex (MFC) involved in translation initiation, Required for the binding of MFC to the 40S ribosome, Required for the processing and nuclear export of the 60S and 40S ribosomal subunits

Belongs to the ABC transporter superfamily, ABCE family


This is Ras-related protein ced-10 protein, from Caenorhabditis elegans, contains 191 amino acids, is membrane-bound, locates in Cell membrane.

Required in engulfing to control the phagocytosis of apoptotic cell corpses (PubMed:10707082, PubMed:20126385), Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells (PubMed:20126385), Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291), ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces (PubMed:10707082), Plays a redundant role with mig-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration, May regulate these 2 processes by activating pak-1 and/or max-2 (PubMed:17050621), Plays a role, probably via mig-10, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt-1, Regulates mig-10 asymmetric distribution in HSN neurons (PubMed:18499456), During the dorso-ventral axonal guidance and outgrowth of VD neurons, required together with mig-2 to inhibit growth cone filopodial protrusion mediated by netrin guidance cue unc-6 and its receptors unc-5 and unc-40 (PubMed:25371370, PubMed:30045855), Specifically, regulates growth cone filopodial protrusion polarity, and thus migration, by promoting F-actin polarization and, together with mig-2, by restricting plus-end microtubule accumulation in the growth cone (PubMed:30045855), Plays a role in protecting dopaminergic neurons from oxidative stress-induced degeneration (PubMed:29346382), During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2 (PubMed:19797046, PubMed:19023419), Furthermore, plays a role in distal tip cell polarity and migration by negatively regulating the unc-6/Netrin receptor unc-5 (PubMed:26292279), May be involved in signal transduction during cell migration (PubMed:10707082), May be involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail (PubMed:24004945)

Belongs to the small GTPase superfamily, Rho family


This is High-osmolarity-induced transcription protein 1 protein, from Baker's yeast, contains 719 amino acids, locates in Nucleus.

Required for a complete transcriptional response to osmotic stress, through recruitment of HOG1 followed by pol II recruitment to the promoters of GPD1 and other HOG-dependent genes


This is COMPASS component SDC1 protein, from Baker's yeast, contains 175 amino acids, locates in Nucleus.

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance


This is Runt-related transcription factor 1 protein, from Mouse, contains 451 amino acids, locates in Nucleus.

Isoform 4 shows higher binding activities for target genes and binds TCR-beta-E2 and RAG-1 target site with threefold higher affinity than other isoforms, It is less effective in the context of neutrophil terminal differentiation


This is Vacuolar protein sorting-associated protein 72 protein, from Baker's yeast, contains 795 amino acids, locates in Nucleus.

Participates in the catalytic exchange of histone H2A for the H2A variant HTZ1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes, Indirectly involved in vacuolar protein sorting


This is Mevalonate kinase protein, from Human, contains 396 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342, PubMed:9392419, PubMed:11278915)

Belongs to the GHMP kinase family, Mevalonate kinase subfamily


This is Lamin-C protein, from Fruit fly, contains 621 amino acids, locates in Nucleus.

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity), In spermatocytes, regulates cytokinesis during meiosis (PubMed:27402967)

Belongs to the intermediate filament family


This is Mitochondrial zinc maintenance protein 1, mitochondrial protein, from Baker's yeast, contains 123 amino acids, is soluble, locates in Mitochondrion.

Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex, Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane, Modulates the mitochondrial matrix zinc pool

Belongs to the complex I LYR family, MZM1 subfamily


This is Vacuolar protein sorting-associated protein 71 protein, from Baker's yeast, contains 280 amino acids, has 1 HIT-type Zinc finger, locates in Nucleus.

HIT-type

Participates in the catalytic exchange of histone H2A for the H2A variant HZT1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes, Indirectly involved in vacuolar protein sorting


This is Non-histone protein 10 protein, from Baker's yeast, contains 203 amino acids, locates in Nucleus.

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex


This is ATP-dependent RNA helicase HAS1 protein, from Baker's yeast, contains 505 amino acids, locates in Nucleus.

ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis, Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA

Belongs to the DEAD box helicase family, DDX18/HAS1 subfamily


This is Protein transport protein GOT1 protein, from Baker's yeast, contains 138 amino acids, is membrane-bound, locates in Golgi apparatus.

Nonessential protein required for the fusion of ER-derived transport vesicles with the Golgi complex, Can be replaced by SFT2


This is Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial protein, from Baker's yeast, contains 464 amino acids, locates in Mitochondrion.

Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria, The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln), Required for HMG2-induced ER-remodeling

Belongs to the amidase family, GatA subfamily


This is Barrier-to-autointegration factor 1 protein, from Caenorhabditis elegans, contains 89 amino acids, locates in Nucleus.

DNA-binding protein which plays an essential role in nuclear envelope formation (PubMed:17170708), Required for normal chromosome segregation during mitosis (PubMed:12684533), Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2 (PubMed:12684533), In association with lem-3, plays a role in radiation-induced DNA damage repair response (PubMed:22383942)


This is G-protein regulator 2 protein, from Caenorhabditis elegans, contains 525 amino acids, is soluble, locates in Cytoplasm.

In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135), Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force (PubMed:12730122), Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122)


This is Sodium-dependent dopamine transporter protein, from Caenorhabditis elegans, contains 615 amino acids, is membrane-bound, locates in Cell membrane.

Dopamine transporter (PubMed:9765501, PubMed:29346382), Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family


This is Weak acid resistance protein 1 protein, from Baker's yeast, contains 944 amino acids, locates in Nucleus.

transcription factor which binds to a weak acid response element (WARE) to mediate stress induction of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively


This is Respiratory supercomplex factor 1, mitochondrial protein, from Baker's yeast, contains 159 amino acids, is membrane-bound, locates in Mitochondrion.

Assembly factor that plays a role in the assembly of the respiratory chain supercomplexes (SCs) composed of ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), Involved in the recruitment of COX13 and RCF2 into cytochrome c oxidase, May also be required for late-stage assembly of the COX12 and COX13 subunits (PubMed:22342701, PubMed:22405070, PubMed:22310663), Required for the generation and maintenance of a normal proton motive force (PMF) across the inner mitochondrial membrane (IMM) by preventing proton leakage through an inactive population of CIV that accumulates when RCF1 and/or RCF2 proteins are absent (PubMed:30683696, PubMed:31591265)


This is U1 SNP1-associating protein 1 protein, from Baker's yeast, contains 838 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Scaffold protein of the endoplasmic reticulum-associated degradation (ERAD) (also known as endoplasmic reticulum quality control, ERQC) pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins, Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M), Has multiple functions in ERAD including recruitment of DER1 to the HRD1 ubiquitin ligase, and regulation of HRD1 activity, Involved in oligomerization of HRD1 and in HRD1 autoubiquitination and degradation


This is Ubiquitin ligase-binding protein BUL2 protein, from Baker's yeast, contains 920 amino acids, is soluble, locates in Cytoplasm.

Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1, The RSP5-BUL1/2 complex is also necessary for the heat-shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2


This is Transcription initiation factor TFIID subunit 12 protein, from Baker's yeast, contains 539 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK, Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription, SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation, SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus


This is Serine/threonine-protein kinase VHS1 protein, from Baker's yeast, contains 461 amino acids, is soluble, locates in Cytoplasm.

Probable serine/threonine protein kinase involved in the G1-S transition

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Zinc finger protein 85 protein, from Human, contains 595 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 14 C2H2-type Zinc finger, has 1 C2H2-type 11; degenerate Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 11; degenerate

Belongs to the krueppel C2H2-type zinc-finger protein family


This is RuvB-like protein 1 protein, from Baker's yeast, contains 463 amino acids, locates in Nucleus.

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes, The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling, The INO80 complex remodels chromatin by shifting nucleosomes, Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates, The INO80 complex is involved in DNA repair by associating to 'Ser-129' phosphorylated H2A histones as a response to DNA damage, RVB1 recruits ARP5 to the INO80 complex, During transcription may recruit SPT15/TBP to the TATA-boxes of involved genes, Required for box C/D and box H/ACA snoRNA accumulation and involved in pre-rRNA processing


This is High mobility group protein 1 protein, from Baker's yeast, contains 246 amino acids, locates in Nucleus.

DNA-binding protein that is probably part of the rDNA transcription apparatus, Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription, May participate in mutagenesis control


This is AT-rich interactive domain-containing protein 5A protein, from Human, contains 594 amino acids, locates in Nucleus.

Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer, May act as repressor and down-regulate enhancer-dependent gene expressison (PubMed:8649988), May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes, May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity), Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852), As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21, Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity, Contributes to elevated IL6 levels possibly implicated in autoimmunity processes, IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells, In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling, Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity), Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity)


This is Something about silencing protein 4 protein, from Baker's yeast, contains 481 amino acids, locates in Nucleus.

Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3, The SAS complex is however unable to acetylate nucleosomal histones, The complex is involved in transcriptional silencing at telomeres and at HML locus, Also involved in rDNA silencing, In the complex, SAS4 is essential for histone acetyltransferase (HAT) activity of the complex


This is Citrate/oxoglutarate carrier protein protein, from Baker's yeast, contains 314 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial antiporter which catalyzes the transport of citrate and oxoglutarate across the membrane, Also shows specificity for oxaloacetate, and to a lesser extent succinate and fumarate, Transports isocitrate, cis-aconitate and L-malate with very low efficiency, Does not show uniporter activity, Helps to maintain normal citrate levels and NADPH/NADP(+) ratios under conditions of oxidative stress, In addition, associates with the mitochondrial nucleoid and binds DNA in vitro, although the relevance of these data in vivo is unclear

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Pre-mRNA-splicing factor SYF1 protein, from Baker's yeast, contains 859 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing and cell cycle control, As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation


This is DNA polymerase eta protein, from Baker's yeast, contains 632 amino acids, has 1 UBZ3-type Zinc finger, locates in Nucleus.

DNA polymerase specifically involved in DNA repair, Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls, Plays an important role in the repair of UV-induced pyrimidine dimers, Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions, Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts

Belongs to the DNA polymerase type-Y family


This is Eukaryotic translation initiation factor 3 subunit G protein, from Baker's yeast, contains 274 amino acids, is soluble, locates in Cytoplasm.

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential), Binds to the 18S rRNA but non-specifically (PubMed:10085088)


This is Histone-lysine N-methyltransferase, H3 lysine-79 specific protein, from Baker's yeast, contains 582 amino acids, locates in Nucleus.

Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3, This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks, Nucleosomes are preferred as substrate compared to free histones, Can bind to DNA (in vitro)

Belongs to the class I-like SAM-binding methyltransferase superfamily, DOT1 family


This is Protein ECM11 protein, from Baker's yeast, contains 302 amino acids, locates in Nucleus.

May be involved in cell wall organization and biogenesis


This is Endopolyphosphatase protein, from Baker's yeast, contains 674 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths, Has both exopolyphosphatase and endopolyphosphatase activities at different ratios depending on divalent cations by cleaving phosphate from the chain end and by fragmenting long-chain polymers into shorter ones, respectively, The limited digestion products are 1 and 3 P(i) residues (PubMed:11102525, PubMed:11447286, PubMed:15170373, PubMed:15342119, PubMed:15792812, PubMed:8900207, Ref,16, PubMed:31175919), Also releases phosphate from dATP, dATP phosphohydrolase activity is about 7-fold lower than the exopolyphosphatase activity (Ref,16)

Belongs to the endopolyphosphatase PPN1 family


This is Crossover junction endonuclease MUS81 protein, from Baker's yeast, contains 632 amino acids, locates in Nucleus.

Interacts with MMS4 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick, Typical substrates include 3'-flap structures, D-loops, replication forks with regressed leading strands and nicked Holliday junctions, Cleavage probably occurs approximately half a helical turn upstream of the free 5'-end in these structures, May be required in mitosis for the processing of stalled replication fork intermediates arising spontaneously or subsequent to treatment with DNA damaging agents such as methylmethane sulfonate (MMS), camptothecin (CPT) or UV, May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI), This involves consecutive cleavage of D-loops and nicked Holliday junctions leading to sister chromatid crossover, In contrast to MSH4-MSH5 dependent crossover, double Holliday junctions do not seem to be involved, Spore formation and viability are severely impaired in deletion strains


This is U3 small nucleolar RNA-associated protein 5 protein, from Baker's yeast, contains 643 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)


This is U3 small nucleolar RNA-associated protein 15 protein, from Baker's yeast, contains 513 amino acids, locates in Nucleus.


This is Lipid phosphate phosphatase 1 protein, from Baker's yeast, contains 274 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG), Together with DPP1, regulates intracellular DGPP and PA levels which are phospholipid molecules believed to play a signaling role in stress response, Can also use lysophosphatidic acid (LPA) as a substrate, Substrate preference is PA > DGPP > LPA

Belongs to the PA-phosphatase related phosphoesterase family


This is Succinate dehydrogenase assembly factor 3, mitochondrial protein, from Baker's yeast, contains 133 amino acids, is soluble, locates in Mitochondrion.

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol, Promotes maturation of the iron-sulfur protein subunit SDH2 of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants, Acts together with SDHAF1 (SDH6)

Belongs to the complex I LYR family, SDHAF3 subfamily


This is Putative glucokinase-2 protein, from Baker's yeast, contains 500 amino acids, is soluble, locates in Cytoplasm.

Putative glucokinase involved in phosphorylation of aldohexoses and glucose uptake (By similarity), Involved in sporulation, Required for the full activation of the early meiotic inducer IME1


This is Glutathione-independent glyoxalase HSP31 protein, from Baker's yeast, contains 237 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step, May play a role in detoxifying endogenously produced glyoxals (PubMed:24302734), Involved in protection against reactive oxygen species (ROS) (PubMed:17395014), Important for viability in stationary phase, May negatively regulate TORC1 in response to nutrient limitation (PubMed:24706893)

Belongs to the peptidase C56 family, HSP31-like subfamily


This is ATP-dependent DNA helicase II subunit 2 protein, from Baker's yeast, contains 629 amino acids, locates in Nucleus.

Single-stranded DNA-dependent ATP-dependent helicase, Involved in non-homologous end joining (NHEJ) DNA double strand break repair, DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA, Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection, Appears to have a role in recruitment of telomerase and CDC13 to the telomere and the subsequent telomere elongation, Required also for telomere recombination to repair telomeric ends in the absence of telomerase, KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase, Involved in telomere maintenance, Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement, Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere, Required for mating-type switching


This is Kinetochore protein SPC24 protein, from Baker's yeast, contains 213 amino acids, locates in Nucleus.

Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity


This is Proline dehydrogenase 1, mitochondrial protein, from Fruit fly, contains 681 amino acids, is soluble, locates in Mitochondrion.

Converts proline to delta-1-pyrroline-5-carboxylate (PubMed:8096642), Involved in the conversion of proline to glutamate, which functions as transmitter at neuromuscular junctions (PubMed:8096642), Glutamate deficiency could possibly account for reduced motor activity (PubMed:8096642)


This is U3 small nucleolar RNA-associated protein 14 protein, from Baker's yeast, contains 899 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA


This is DNA polymerase epsilon subunit D protein, from Baker's yeast, contains 196 amino acids, locates in Nucleus.

As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication, It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork, It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication, It is also involved in DNA synthesis during DNA repair, Also functions as component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA, The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing, It is involved in repression of MAT a-specific genes, INO1, and early meiotic genes during mitotic growth dependent upon transcription factor UME6 and in a parallel pathway to the RPD3-SIN3 histone deacetylase complex


This is Palmitoyltransferase SWF1 protein, from Baker's yeast, contains 336 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Palmitoyltransferase that targets several endosomal SNAREs, Palmitoylates the SNAREs SNC1, SNC2, SYN8 and TLG1, at cysteine residues close to the cytoplasmic end of their transmembrane domain, May have a role in the cellular quality control of transmembrane domain-containing proteins

Belongs to the DHHC palmitoyltransferase family, SWF1 subfamily


This is FACT complex subunit POB3 protein, from Baker's yeast, contains 552 amino acids, locates in Nucleus.

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes, The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair, During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure, It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II, Transcription elongation is promoted by the repression of transcription initiation from cryptic sites, Also acts in establishing transcription initiation complexes and promotes SPT15/TBP-binding to a TATA box, Together with replication factor-A protein (RPA), FACT may play a role in nucleosome deposition during DNA replication


This is Chromosome segregation in meiosis protein 3 protein, from Baker's yeast, contains 317 amino acids, locates in Nucleus.

Forms a fork protection complex (FPC) with TOF1 which is required for chromosome segregation during meiosis and DNA damage repair, FPC coordinates leading and lagging strand synthesis and moves with the replication fork, FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors and protects stalled replication forks against the fork-releasing activity of RRM3 helicase


This is Ribosome biogenesis protein ERB1 protein, from Baker's yeast, contains 807 amino acids, is soluble, locates in Nucleus.

Component of the NOP7 complex, which is required for maturation of the 25S and 5,8S ribosomal RNAs and formation of the 60S ribosome

Belongs to the WD repeat BOP1/ERB1 family


This is Transducin-like enhancer protein 1 protein, from Human, contains 770 amino acids, locates in Nucleus.

Transcriptional corepressor that binds to a number of transcription factors, Inhibits NF-kappa-B-regulated gene expression, Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling, Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity), The effects of full-length TLE family members may be modulated by association with dominant-negative AES, Unusual function as coactivator for ESRRG

Belongs to the WD repeat Groucho/TLE family


This is Arginine biosynthesis bifunctional protein ArgJ, mitochondrial protein, from Baker's yeast, contains 441 amino acids, is soluble, locates in Mitochondrion.

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate


This is Transcriptional regulatory protein RCO1 protein, from Baker's yeast, contains 684 amino acids, has 1 PHD-type Zinc finger, has 1 PHD-type 2; atypical Zinc finger, locates in Nucleus.

PHD-type

PHD-type 2; atypical

Catalytic component of the RPD3C(S) histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, DNA damage response, osmotic stress response and developmental events


This is 31 kDa ribonucleoprotein, chloroplastic protein, from Mouse-ear cress, contains 329 amino acids, locates in Plastid.

Required for specific RNA editing events in chloroplasts and stabilizes specific chloroplast mRNAs, Associates with the 3'-terminus ndhF mRNAs and protects them against 3'-exonucleolytic degradation (PubMed:19297624, PubMed:23110894), Required for normal chloroplast development under cold stress conditions by stabilizing transcripts of numerous mRNAs under these conditions (PubMed:23110894), May modulate telomere replication through RNA binding domains (PubMed:14703514)


This is Single-stranded DNA-binding protein, mitochondrial protein, from Human, contains 148 amino acids, is soluble, locates in Mitochondrion.

Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240), In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:21953457, PubMed:12975372, PubMed:26446790, PubMed:15167897, PubMed:31550240), Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:26446790, PubMed:21953457, PubMed:31550240), In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372), May also function in mtDNA repair (PubMed:23290262)


This is Transcription factor SOX-13 protein, from Mouse, contains 613 amino acids, locates in Nucleus.

Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:9524265, PubMed:9421502), Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805), Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805), Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (PubMed:17218525, PubMed:23562159, PubMed:30413363), Required for the differentiation of Vgamma2-positive gamma-delta T-cells, a subset of IL17A expressing gamma-delta T-cells (PubMed:23562159), Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (PubMed:23562159), Promotes brown adipocyte differentiation (PubMed:27923061), Inhibitor of WNT signaling (By similarity)


This is Reticulon-like protein 1 protein, from Baker's yeast, contains 295 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Probable family 17 glucosidase SCW10 protein, from Baker's yeast, contains 389 amino acids, is soluble, locates in Extracellular.

Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation

Belongs to the glycosyl hydrolase 17 family


This is Transcription initiation factor TFIID subunit 9 protein, from Baker's yeast, contains 157 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complex SAGA and SLIK, Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription, SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3, and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus


This is Protein BCH1 protein, from Baker's yeast, contains 724 amino acids, is membrane-bound, locates in Golgi apparatus.

Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3


This is Cell division control protein 42 homolog protein, from Caenorhabditis elegans, contains 191 amino acids, is membrane-bound, locates in Cell membrane.

Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins, Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3 (PubMed:11412996, PubMed:11412997), Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization (PubMed:8824291), During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation, probably by activating max-2 (PubMed:19797046, PubMed:19023419), May play a role in controlling canal length and in maintaining Golgi and ER stability during excretory canal elongation, probably downstream of ccm-3, which may regulate its activity and expression levels (PubMed:25743393), May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis (PubMed:19798448), Involved in toca-1 and toca-2-mediated protein trafficking controlling the recycling of endocytic cargo protein mig-14 to the Golgi apparatus (PubMed:25775511), Plays a role in male tail tip morphogenesis (PubMed:21408209), Together with kpc-1 and chin-1, plays a role in guiding axons from neurons, including AIY interneurons, into the nerve ring (PubMed:28846083)

Belongs to the small GTPase superfamily, Rho family, CDC42 subfamily


This is FACT complex subunit SSRP1 protein, from Mouse-ear cress, contains 646 amino acids, locates in Nucleus.

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes, The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair, During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure, It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II, Binds specifically to double-stranded DNA (Probable), Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus (PubMed:16698901)


This is Dynamin-1 protein, from Human, contains 864 amino acids, is soluble, locates in Cytoplasm.

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP, Most probably involved in vesicular trafficking processes, Involved in receptor-mediated endocytosis

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is FACT complex subunit Ssrp1 protein, from Fruit fly, contains 723 amino acids, locates in Nucleus.

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes, The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair, During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure, It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II, Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U, The FACT complex is required for expression of Hox genes


This is Protein ERP1 protein, from Baker's yeast, contains 219 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vesicular protein trafficking


This is Diacylglycerol pyrophosphate phosphatase 1 protein, from Baker's yeast, contains 289 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG), Together with LPP1, regulates intracellular DGPP and PA levels, which are phospholipid molecules believed to play a signaling role in stress response, Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates, Substrate preference is DGPP > LPA > PA, Activity is independent of a divalent cation ion and insensitive to inhibition by N-ethylmaleimide


This is E3 ubiquitin-protein ligase HEL2 protein, from Baker's yeast, contains 639 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, leading to degradation of nascent peptide chains (PubMed:28757607, PubMed:28223409, PubMed:30609991, PubMed:31819057, PubMed:31532761, PubMed:32615089, PubMed:32203490, PubMed:33338396, PubMed:36627279), HEL2 is activated when ribosomes are stalled within an mRNA following translation of prematurely polyadenylated mRNAs (PubMed:28757607), Acts as a ribosome collision sensor: specifically recognizes and binds collided ribosome and ubiquitinates the 40S ribosomal proteins RPS20/uS10 and RPS3/uS3 (PubMed:30609991, PubMed:31819057, PubMed:32615089, PubMed:32203490), Catalyzes 'Lys-63'-linked polyubiquitination of RPS20/uS10, promoting recruitment of the RQT (ribosome quality control trigger) complex, which drives the disassembly of stalled ribosomes, followed by degradation of nascent peptides (PubMed:30609991, PubMed:31819057, PubMed:36627279), HEL2 also acts as an activator of the No-Go decay (NGD) pathway by mediating polyubiquitination of monoubiquitinated RPS3/uS3 and RPS7/es7: RPS3/uS3 and RPS7/es7 are first monoubiquitinated by MAG2 and MOT2/NOT4, respectively, and HEL2 mediates formation of 'Lys-63'-linked polyubiquitin chains on monoubiquitin, leading to activation of the NGD pathway in a CUE2-mediated endonucleolytic cleavage (PubMed:28943311, PubMed:30893611, PubMed:30609991, PubMed:30718516), Polyubiquitination of RPS3/uS3 also triggers degradation of non-functional 18S rRNA (PubMed:30893611, PubMed:30718516), The RQC pathway and the integrated stress response (ISR) antagonize each other: HEL2 prevents the activation of GCN2, while GCN2 suppresses RQC activation (PubMed:32615089, PubMed:33338396), The RQC pathway functions as a preventive quality control in the secretory pathway: HEL2 binds preferentially to the pre-engaged secretory ribosome-nascent chain complexes and prevents mistargeting of secretory proteins into mitochondria (PubMed:33761353), Independently of its role in RQC, also involved in the polyubiquitination and proteasomal-degradation of excess histone proteins (PubMed:22570702)


This is Ankyrin repeat domain-containing protein, chloroplastic protein, from Mouse-ear cress, contains 435 amino acids, locates in Plastid.

Involved in the initial differentiation of the proplastid during the embryo development and in plastid differentiation linked to cell differentiation, morphogenesis and organogenesis during the plant life cycle


This is Eukaryotic translation initiation factor 3 subunit J protein, from Baker's yeast, contains 265 amino acids, is soluble, locates in Cytoplasm.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation


This is Protein UPS1, mitochondrial protein, from Baker's yeast, contains 175 amino acids, is membrane-bound, locates in Mitochondrion.

Required for maintenance of normal mitochondrial morphology (PubMed:16754953, PubMed:26071601), Required for PCP1-dependent processing of MGM1 (PubMed:16754953), The UPS1:MDM35 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space (PubMed:26071602, PubMed:26071601, PubMed:26235513), Phosphatidic acid release requires dissociation of the UPS1:MDM35 complex (PubMed:26235513), Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane (PubMed:26071602), With UPS2, controls the level of cardiolipin in mitochondria (PubMed:19506038), Cardiolipin is a unique phospholipid with four fatty acid chains and is present mainly in the mitochondrial inner membrane where it stabilizes the electron transport chain supercomplex between complexes III and IV through direct interaction of their subunits


This is Ubiquinone biosynthesis protein COQ9, mitochondrial protein, from Baker's yeast, contains 260 amino acids, is membrane-bound, locates in Mitochondrion.

Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration


This is 3,2-trans-enoyl-CoA isomerase protein, from Baker's yeast, contains 280 amino acids, locates in Peroxisome.

Essential for the beta oxidation of unsaturated fatty acids

Belongs to the enoyl-CoA hydratase/isomerase family


This is Magnesium transporter MRS2-11, chloroplastic protein, from Mouse-ear cress, contains 459 amino acids, is membrane-bound, locates in Plastid.

High-affinity magnesium transporter that mediates the influx of magnesium in chloroplast

Belongs to the CorA metal ion transporter (MIT) (TC 1,A,35,5) family


This is U1 small nuclear ribonucleoprotein C protein, from Baker's yeast, contains 231 amino acids, has 1 Matrin-type Zinc finger, locates in Nucleus.

Matrin-type

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome, YHC1/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing, The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA, Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region

Belongs to the U1 small nuclear ribonucleoprotein C family


This is Glutathione hydrolase proenzyme protein, from Baker's yeast, contains 660 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides, Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH, Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation

Belongs to the gamma-glutamyltransferase family


This is Iron-sulfur cluster biogenesis chaperone, mitochondrial protein, from Baker's yeast, contains 657 amino acids, is soluble, locates in Mitochondrion.

Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria (PubMed:10779357, PubMed:11273703, PubMed:12756240, PubMed:15123690, PubMed:15958384, PubMed:16431909, PubMed:9660806, PubMed:31040179), Assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins ISU1/ISU2 to GRX5 (PubMed:11273703, PubMed:12756240, PubMed:15123690, PubMed:15958384, PubMed:16431909, PubMed:31040179, PubMed:26545917, PubMed:23615440)

Belongs to the heat shock protein 70 family


This is U3 small nucleolar RNA-associated protein 13 protein, from Baker's yeast, contains 817 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA


This is Seipin protein, from Baker's yeast, contains 285 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size (PubMed:18093937, PubMed:18250201), Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm (PubMed:25540432)


This is U3 small nucleolar RNA-associated protein 21 protein, from Baker's yeast, contains 939 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly


This is mRNA 3'-end-processing protein YTH1 protein, from Baker's yeast, contains 208 amino acids, has 5 C3H1-type Zinc finger, locates in Nucleus.

RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB


This is Multiple RNA-binding domain-containing protein 1 protein, from Baker's yeast, contains 887 amino acids, locates in Nucleus.

Involved in pre-rRNA processing, Required for maintaining steady-state levels of 40S ribosomal subunit, Required for the initial processing of pre-rRNA at the A0 to A2 sites, leading to the processing of the 23S pre-rRNA intermediate to the 18S rRNA


This is Suppressor of glycerol defect protein 1 protein, from Baker's yeast, contains 899 amino acids, locates in Nucleus.

Involved in osmoregulatory glycerol response, probably through its interaction with PLC1 which regulates the expression of GDP1


This is 3-ketodihydrosphingosine reductase protein, from Human, contains 332 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Mitochondrial dicarboxylate transporter protein, from Baker's yeast, contains 298 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate, Required for growth on ethanol and acetate

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Protein ORM2 protein, from Baker's yeast, contains 216 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis, Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity


This is Sphingoid long chain base kinase 5 protein, from Baker's yeast, contains 687 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:9677363, PubMed:11102354, PubMed:12493772, PubMed:25345524), Redundant to LCB4, is only responsible for few percent of the total activity (PubMed:9677363), Involved in the biosynthesis of sphingolipids and ceramides (PubMed:9677363, PubMed:25345524), Involved in heat-induced transient cell cycle arrest (PubMed:11056159), Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11102354, PubMed:11278643), Involved in heat-stress resistance (PubMed:11056159)


This is Chromatin structure-remodeling complex subunit SFH1 protein, from Baker's yeast, contains 426 amino acids, locates in Nucleus.

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is essential for mitotic growth and required for cell cycle progression


This is FK506-binding protein 4 protein, from Baker's yeast, contains 392 amino acids, locates in Nucleus.

PPIase that acts as a histone chaperone (PubMed:14981505, PubMed:16846601), Histone proline isomerase that increases the rate of cis-trans isomerization at 'Pro-17' (H3P16), 'Pro-31' (H3P30) and 'Pro-39 (H3P38) on the histone H3 N-terminal tail (PubMed:16959570, PubMed:23888048), H3P16 and H3P30 are the major proline targets with little activity shown against H3P38 (PubMed:23888048), H3P38 isomerization influences SET2-mediated H3K36 methylation thereby regulating gene expression (PubMed:16959570)

Belongs to the FKBP-type PPIase family, FKBP3/4 subfamily


This is Mediator of RNA polymerase II transcription subunit 10 protein, from Baker's yeast, contains 157 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins

Belongs to the Mediator complex subunit 10 family


This is ATP-dependent RNA helicase DBP9 protein, from Baker's yeast, contains 594 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5,8S rRNAs

Belongs to the DEAD box helicase family, DDX56/DBP9 subfamily


This is Protein TOS4 protein, from Baker's yeast, contains 489 amino acids, locates in Nucleus.

Binds to the promoters of genes with functions important for the G1/S (start) transition; primarily genes involved in pheromone response, polarized growth and transcription


This is Ribosomal RNA small subunit methyltransferase NEP1 protein, from Baker's yeast, contains 252 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1189 (Psi1189) in 18S rRNA, Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA, N1-methylation is independent on acp-modification at the N3-position of U1191, Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 (RPS19A/RPS19B) during the formation of pre-ribosomes

Belongs to the class IV-like SAM-binding methyltransferase superfamily, RNA methyltransferase NEP1 family


This is Transcription factor tau 91 kDa subunit protein, from Baker's yeast, contains 672 amino acids, locates in Nucleus.

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements, Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function, Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes, Cooperates with TFC3 in DNA binding


This is Pre-rRNA-processing protein ESF1 protein, from Baker's yeast, contains 628 amino acids, locates in Nucleus.

Involved in the 18S rRNA synthesis, Required for the early cleavages at sites A0, A1 and A2


This is Inositol phosphorylceramide synthase regulatory subunit KEI1 protein, from Baker's yeast, contains 221 amino acids, is membrane-bound, locates in Golgi apparatus.

Regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis, Helps the medial Golgi localization of IPC synthase in a COPI vesicle-dependent manner


This is Transaminated amino acid decarboxylase protein, from Baker's yeast, contains 635 amino acids, is soluble, locates in Cytoplasm.

One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism, The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids), In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols, Its preferred substrates are the transaminated amino acids derived from phenylalanine (phenylpyruvate), tryptophan (3-(indol-3-yl)pyruvate), and probably tyrosine (4-hydroxyphenylpyruvate), but also isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate) and methionine (4-methylthio-2-oxobutanoate), whereas transaminated leucine (4-methyl-2-oxopentanoate, also alpha-keto-isocaproate) is a low efficiency substrate and transaminated valine and pyruvate are no substrates, In analogy to the pyruvate decarboxylases the enzyme may in a side-reaction catalyze condensation (or carboligation) reactions leading to the formation of 2-hydroxy ketone, collectively called acyloins


This is Putative POU domain, class 5, transcription factor 1B protein, from Human, contains 359 amino acids, locates in Nucleus.

Shows weak transcriptional activator activity

Belongs to the POU transcription factor family, Class-5 subfamily


This is Protein CBFA2T1 protein, from Human, contains 604 amino acids, has 1 MYND-type Zinc finger, locates in Nucleus.

MYND-type

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654), Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453), Can repress transactivation mediated by TCF12 (PubMed:16803958), Acts as a negative regulator of adipogenesis (By similarity), The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588)


This is LETM1 domain-containing protein YLH47, mitochondrial protein, from Baker's yeast, contains 454 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation


This is N-terminal acetyltransferase B complex catalytic subunit NAT3 protein, from Baker's yeast, contains 195 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met, NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions, it is presumed to N-acetylate 15% of all yeast proteins

Belongs to the acetyltransferase family, GNAT subfamily


This is Transcription factor SPN1 protein, from Baker's yeast, contains 410 amino acids, locates in Nucleus.

Transcription factor involved in RNA polymerase II transcription regulation, May function in both SPT15/TBP post-recruitment and recruitment steps of transcription


This is Ribosomal RNA-processing protein 9 protein, from Baker's yeast, contains 573 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Required for efficient pre-rRNA cleavage at sites A0, A1 and A2, and biosynthesis of 18S rRNA


This is Nucleolar complex protein 4 protein, from Baker's yeast, contains 552 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly, Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm, Its subcellular location and association with pre-40S subunit are unaffected by RPS19 disruptions, suggesting it acts before the ribosomal protein


This is E3 ubiquitin-protein ligase RING1 protein, from Human, contains 406 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation, H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility, Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity


This is Arsenical-resistance protein 3 protein, from Baker's yeast, contains 404 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane transporter that confers resistance to toxic metalloids by mediating extrusion of arsenite (As(III)) and antimonite (Sb(III)) out of cells, Displays low-affinity As(III)/H(+) and Sb(III)/H(+) exchange activity

Belongs to the arsenical resistance-3 (ACR3) (TC 2,A,59) family


This is HDA1 complex subunit 3 protein, from Baker's yeast, contains 655 amino acids, locates in Nucleus.

Required for activity of HDA1 histone deacetylase complex, The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events

Belongs to the HDA2/3 family, HDA3 subfamily


This is HDA1 complex subunit 2 protein, from Baker's yeast, contains 674 amino acids, locates in Nucleus.

Belongs to the HDA2/3 family, HDA2 subfamily


This is Protein BFR2 protein, from Baker's yeast, contains 534 amino acids, locates in Nucleus.

Involved in endoplasmic reticulum to Golgi transport, Involved in a protein-transport step blocked by brefeldin A, which disrupts the Golgi apparatus and its incoming protein flux, May also be involved for mass growth or cell proliferation


This is Chromatin structure-remodeling complex protein RSC3 protein, from Baker's yeast, contains 885 amino acids, locates in Nucleus.

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton, This subunit is required for transcription of ribosomal protein genes and genes involved in the integrity of the cell wall, and also for proper metaphase progression, Together with HTL1, LDB7, NPL6, RSC30 components, defines a fungal-specific module within the RSC complex that plays a role in many cellular functions including the maintenance of cell wall integrity


This is Cell division control protein 73 protein, from Baker's yeast, contains 393 amino acids, is soluble, locates in Nucleus.

The PAF1 complex is a multifunctional complex, Involved in transcription initiation via genetic interactions with TATA-binding proteins, Involved in elongation, It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II, Also has a role in transcription-coupled histone modification, Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B, Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2


This is Vacuole morphology and inheritance protein 14 protein, from Baker's yeast, contains 880 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization, Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock, Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity


This is Glycine--tRNA ligase 2 protein, from Baker's yeast, contains 618 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:23816885), Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs, Thereby, may play a special role in Ap4A homeostasis (By similarity)

Belongs to the class-II aminoacyl-tRNA synthetase family


This is Nucleus-vacuole junction protein 2 protein, from Baker's yeast, contains 770 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, induces contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation


This is Calcium-dependent protein kinase 1 protein, from Mouse-ear cress, contains 610 amino acids, is membrane-bound, locates in Peroxisome.

May play a role in signal transduction pathways that involve calcium as a second messenger, Phosphorylates the Ca(2+)-ATPase ACA2 resulting in the inhibition of its calcium activation

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDPK subfamily


This is Transcription factor SOX-4 protein, from Human, contains 474 amino acids, locates in Nucleus.

Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772), Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity), Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311)


This is Denmotoxin protein, from Mangrove snake, contains 111 amino acids, is soluble, locates in Extracellular.

This bird-specific postsynaptic neurotoxin irreversibly binds and inhibits the chick muscle alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHNRD) nicotinic acetylcholine receptor (nAChR) 100-fold more compared with the mouse receptor, The weak binding to mouse receptor is reversible

Belongs to the snake three-finger toxin family, Ancestral subfamily, Boigatoxin sub-subfamily


This is Uric acid-xanthine permease protein, from Aspergillus nidulans, contains 574 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2,A,40) family


This is Thiamine metabolism regulatory protein THI3 protein, from Baker's yeast, contains 609 amino acids, locates in Nucleus.

One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism, The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids), In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols, Its preferred substrates are the transaminated amino acids derived from leucine (4-methyl-2-oxopentanoate, also alpha-keto-isocaproate) and isoleucine ((3S)-3-methyl-2-oxopentanoate, also alpha-keto-beta-methylvalerate), whereas transaminated valine, transaminated aromatic amino acids, and pyruvate are no substrates, In analogy to the pyruvate decarboxylases the enzyme may in a side-reaction catalyze condensation (or carboligation) reactions leading to the formation of 2-hydroxy ketone, collectively called acyloins, The enzyme is also positively regulating the thiamine metabolism by a molecular mechanism that may involve thiamine concentration sensing and signal transmission


This is ATP-dependent RNA helicase SUB2 protein, from Baker's yeast, contains 446 amino acids, locates in Nucleus.

ATP-binding RNA helicase component of the TREX complex involved in transcription elongation and required for the export of mRNA out of the nucleus, SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly, May be involved in rDNA and telomeric silencing, and maintenance of genome integrity

Belongs to the DEAD box helicase family, DECD subfamily


This is Frataxin homolog, mitochondrial protein, from Baker's yeast, contains 174 amino acids, is soluble, locates in Mitochondrion.

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways, Plays a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+), Can store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization, May be involved in regulation of the mitochondrial electron transport chain


This is Sperm-associated antigen 1 protein, from Human, contains 926 amino acids, is soluble, locates in Cytoplasm.

May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity), May play a role in fertilization, Binds GTP and has GTPase activity


This is KH domain-containing, RNA-binding, signal transduction-associated protein 1 protein, from Human, contains 443 amino acids, is membrane-bound, locates in Nucleus.

Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase


This is Histone acetyltransferase RTT109 protein, from Baker's yeast, contains 436 amino acids, locates in Nucleus.

Histone chaperone-dependent acetylase that modifies 'Lys-9', 'Lys-14', 'Lys-23', 'Lys-27', and 'Lys-56' on histone H3 (H3K9Ac, H3K14Ac and H3K23Ac, H3K27Ac, and H3K56Ac) to promote nucleosome assembly, genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:31194870, PubMed:17046836, PubMed:17369253, PubMed:17320445, PubMed:17272723, PubMed:18723682, PubMed:20560668, PubMed:21256037, PubMed:29300933, PubMed:19172748, PubMed:19683497), Its residue selectivity is influenced by the acetylation status of histone H3, and also the presence of histone chaperone ASF1 that shifts selectivity to 'Lys-56' when H3K14Ac is already present (PubMed:31194870), H3K56 acetylation weakens the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly (PubMed:18577595), Autoacetylates (PubMed:18568037, PubMed:18707894, PubMed:18719104), Independently of acetyltransferase activity, stimulates histone deposition by VPS75 (PubMed:19172748), Involved in regulation of Ty1 transposition (PubMed:11779788)


This is Phosphatase PSR1 protein, from Baker's yeast, contains 427 amino acids, is membrane-bound, locates in Cell membrane.

Has phosphatase activity in vitro, Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2, Acts through a calcineurin-independent pathway and is functionally redundant with PSR2, Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2


This is Polyamine transporter 1 protein, from Baker's yeast, contains 586 amino acids, is membrane-bound, locates in Cell membrane.

Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm, Catalyzes polyamine uptake at alkaline pH and excretion at acidic pH, Recognizes spermidine, spermine and putrescine, the polyamine analogs methylglyoxal bis(guanylhydrazone) (MGBG) and paraquat, the antimalarial drug quinidine, and cycloheximide, Confers resistance to the non-steroidal anti-inflammatory drug indomethacin

Belongs to the major facilitator superfamily, DHA1 family, Polyamines/proton antiporter (TC 2,A,1,2,16) subfamily


This is Nucleolar complex-associated protein 3 protein, from Baker's yeast, contains 663 amino acids, locates in Nucleus.

Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm, Also required for initiation of DNA replication, May function downstream of the origin recognition complex (ORC complex) in the loading of CDC6 and the minichromosome maintenance complex (MCM complex) onto chromatin during the G1 phase of the cell cycle, Essential for growth


This is Mitochondrial import inner membrane translocase subunit TIM14 protein, from Baker's yeast, contains 168 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner, In the complex, it is required to stimulate activity of mtHSP70 (SSC1)


This is Ribosome biogenesis protein RLP24 protein, from Baker's yeast, contains 199 amino acids, locates in Cytoplasm.

Involved in the biogenesis of the 60S ribosomal subunit (PubMed:12808088, PubMed:23185031), Ensures the docking of NOG1 to pre-60S ribosomal particles (PubMed:12808088), Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles (PubMed:23185031)

Belongs to the eukaryotic ribosomal protein eL24 family


This is Sterol esterase 2 protein, from Baker's yeast, contains 538 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the hydrolysis of steryl esters, Required for mobilization of steryl ester, thereby playing a central role in lipid metabolism


This is Serine/arginine-rich splicing factor 1 protein, from Human, contains 248 amino acids, locates in Cytoplasm.

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing, Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF, Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA, Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC, Binds preferentially to the 5'-CGAGGCG-3' motif in vitro, Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing, Isoform ASF-2 and isoform ASF-3 act as splicing repressors, May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway

Belongs to the splicing factor SR family


This is T-box transcription factor T-A protein, from Zebrafish, contains 423 amino acids, locates in Nucleus.

Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself, Indispensable for the formation of the notochord and the tail structure, Functions together with tbx16/spadetail in development of trunk and tail mesoderm, Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation, Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail formation, Required for the morphogenesis of Kupffer's vesicle and regulates left-right asymmetry


This is Membrane-anchored lipid-binding protein LAM6 protein, from Baker's yeast, contains 693 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in regulation of various organellar membrane contact sites (PubMed:26119743), May be involved in sterol transfer between intracellular membranes (PubMed:26001273), Selectively transports sterols between membranes in vitro, Involved in stress-dependent formation of sterol-enriched vacuolar membrane domains (PubMed:25987606)


This is Cell division control protein 45 protein, from Baker's yeast, contains 650 amino acids, locates in Nucleus.

Required for initiation of chromosomal DNA replication, Acts at the origin of replication, Also has a role in minichromosome maintenance


This is ERAD-associated E3 ubiquitin-protein ligase HRD1 protein, from Baker's yeast, contains 551 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type; atypical

E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC1 and UBC7 E2 ligases, and transfers it to substrates promoting their degradation, Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD), Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M), In ERAD-L, facilitates retrotranslocation of misfolded proteins from the ER lumen through the ER membrane in conjunction with DER1 (PubMed:32327568), Both proteins have lateral gates facing each other which form a channel through the ER membrane and which distort the membrane region between the lateral gates, making it much thinner than a normal phospholipid bilayer (PubMed:32327568), Substrates insert into the membrane as a hairpin loop with one strand interacting with DER1 and the other with HRD1, ERAD-L substrates are ubiquitinated through HRD1 in conjunction with the E2 ubiquitin-conjugating enzymes UBC1 and UBC7-CUE1, Ubiquitinated substrates are then removed to the cytosol via the action of the CDC48-NPL4-UFD1 ATPase complex and targeted to the proteasome, ERAD-M substrates are processed by the same HRD1-HRD3 core complex, but only a subset of the other components is required for ERAD-M


This is Serine/arginine-rich splicing factor 4 protein, from Human, contains 494 amino acids, locates in Nucleus.

Plays a role in alternative splice site selection during pre-mRNA splicing, Represses the splicing of MAPT/Tau exon 10


This is Endonuclease III homolog 2 protein, from Baker's yeast, contains 380 amino acids, locates in Nucleus.

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage, The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site, The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, Primarily recognizes and repairs oxidative base damage of pyrimidines, but also purine-derived lesions, alkylation damage as well as abasic sites, Can also repair the oxidation products of 8-oxoguanine


This is Nuclear mRNA export protein THP1 protein, from Baker's yeast, contains 455 amino acids, locates in Nucleus.

Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm, SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket, THP1 binds to RNA in vitro


This is Protein ZEO1 protein, from Baker's yeast, contains 113 amino acids, is membrane-bound, locates in Cell membrane.

Acts antagonistically to MID2 in signaling cell wall stress to the PKC1-MPK1 cell integrity pathway


This is Quinone oxidoreductase protein, from Human, contains 329 amino acids, is soluble, locates in Cytoplasm.

Does not have alcohol dehydrogenase activity, Binds NADP and acts through a one-electron transfer process, Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro), May act in the detoxification of xenobiotics, Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species, Enhances the stability of mRNA coding for BCL2, NADPH binding interferes with mRNA binding

Belongs to the zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily


This is Sodium-dependent phosphate transporter 2 protein, from Human, contains 652 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants

Belongs to the inorganic phosphate transporter (PiT) (TC 2,A,20) family


This is Galectin-3-binding protein protein, from Human, contains 585 amino acids, is soluble, locates in Extracellular.

Promotes integrin-mediated cell adhesion, May stimulate host defense against viruses and tumor cells


This is Sphingoid long-chain base transporter RSB1 protein, from Baker's yeast, contains 382 amino acids, is membrane-bound, locates in Cell membrane.

Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop), Involved in the establishment of the functional lipid asymmetry of the plasma membrane, Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels

Belongs to the lipid-translocating exporter (LTE) (TC 9,A,26,1) family


This is GTPase-activating protein GYP1 protein, from Baker's yeast, contains 637 amino acids, locates in Golgi apparatus.

GTPase-activating protein (GAP) that stimulates specifically the intrinsic GTPase activity of Ypt/Rab-type GTPases YPT1 and YPT7 (PubMed:11359917, PubMed:19386605), Functions on the Golgi as a negative regulator of YPT1 (PubMed:11359917), Functions on the vacuole as a negative regulator of YPT7 (PubMed:11118206, PubMed:19386605), It is also active on SEC4 and YPT51 (PubMed:10508155), Provides a catalytic arginine (arginine finger) and glutamine (glutamine finger) in trans to accelerate the GTP hydrolysis rate of the substrate GTPase (Probable) (PubMed:16855591)


This is Superkiller protein 7 protein, from Baker's yeast, contains 747 amino acids, is soluble, locates in Cytoplasm.

Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system, Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway, By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD), May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family


This is Bud site selection protein 21 protein, from Baker's yeast, contains 214 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Has a role in bud site selection maybe via the regulation of expression of bipolar budding components


This is Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase protein, from Baker's yeast, contains 271 amino acids, locates in Peroxisome.

Peroxisomal di-isomerase that is involved in fatty acid metabolism enzyme by converting 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs (PubMed:10381339, PubMed:10455114), Required for ECI1 to be locazed to the peroxisome (PubMed:10381339, PubMed:11302517)

Belongs to the enoyl-CoA hydratase/isomerase family


This is tRNA(Thr) (cytosine(32)-N(3))-methyltransferase protein, from Baker's yeast, contains 628 amino acids, is soluble, locates in Cytoplasm.

S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr) and tRNA(Ser) (PubMed:21518804, PubMed:21518805, PubMed:28003514), N(3)-methylcytidine methylation of tRNA(Thr) requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:28003514), N(3)-methylcytidine methylation of tRNA(Ser) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by MOD5 as prerequisite (PubMed:28003514), Methylation of tRNA(Ser) is also stimulated by SES1 (PubMed:28003514), Binds F-actin and shows weak F-actin cross-linking activity (PubMed:9467951)

Belongs to the methyltransferase superfamily, METL family


This is Multisubstrate pseudouridine synthase 7 protein, from Baker's yeast, contains 676 amino acids, locates in Nucleus.

Catalyzes pseudouridylation at position 35 in U2 snRNA stem-loop II region which induces particular conformation of the mRNA-U2 snRNA duplex and places the nucleophile in an accessible position for the first step of splicing (PubMed:12426583, PubMed:12682021, PubMed:15611063, PubMed:18435545, PubMed:19114708, PubMed:25219674), Also catalyzes pseudouridylation at position 56 in U2 snRNA (PubMed:21131909), Catalyzes also pseudouridylation at position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr) (PubMed:14561887, PubMed:18332121, PubMed:25219674, PubMed:35058356), Pseudouridine residues in tRNAs may stabilize the local RNA conformation, favor interactions with protein partners and play an important role in the stabilization of the codon-anticodon interaction with mRNA (PubMed:14561887), Also catalyzes pseudouridylation of mRNAs in response to heat shock: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAR-3' (PubMed:25219674, PubMed:35058356)

Belongs to the pseudouridine synthase TruD family


This is Anaphase-promoting complex subunit 5 protein, from Baker's yeast, contains 685 amino acids, locates in Nucleus.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle, The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome, In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition, In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication


This is N-alpha-acetyltransferase NAT5 protein, from Baker's yeast, contains 176 amino acids, is soluble, locates in Cytoplasm.

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:25886145), Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (PubMed:25886145), Non-essential component of the NatA N-terminal acetyltransferase (PubMed:14517307)


This is Leukocyte surface antigen CD47 protein, from Human, contains 323 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453), Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:8550562, PubMed:7691831), Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:19004835, PubMed:8550562, PubMed:11509594, PubMed:7691831, PubMed:32679764, PubMed:15383453), Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621), Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity), Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity), Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594), Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453), Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity), Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764), In response to THBS1, negatively modulates wound healing (By similarity), Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity), May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831), May prevent premature elimination of red blood cells (By similarity)


This is Aquaporin PIP1-3 protein, from Mouse-ear cress, contains 286 amino acids, is membrane-bound, locates in Cell membrane.

Water channel required to facilitate the transport of water across cell membrane, Its function is impaired by Hg(2+)

Belongs to the MIP/aquaporin (TC 1,A,8) family, PIP (TC 1,A,8,11) subfamily


This is Upstream activation factor subunit UAF30 protein, from Baker's yeast, contains 228 amino acids, locates in Nucleus.

Nonessential component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex, Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level, UAF30 seems to play a role in silencing transcription by RNA polymerase II