This is Mu-conotoxin cal12b protein, from California cone, contains 87 amino acids, is soluble, locates in Extracellular.

Mu-conotoxins block voltage-gated sodium channels, This toxin reversibly blocks voltage-gated sodium channel in cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation, Has no effect on sodium channels of the two gastropod S,luhuanus and A,californica (which are not natural prey)


This is Mulatexin protein, from White mulberry, contains 415 amino acids, is soluble, locates in Extracellular.

Chitin-binding protein which slows larval growth when consumed by the lepidopteran species S,ricini and M,brassica, but not when consumed by the mulberry specialist B,mori, Lacks chitinase activity


This is POU domain, class 5, transcription factor 3 protein, from Chicken, contains 389 amino acids, locates in Nucleus.

Required for the maintenance of pluripotency and self-renewal of embryonic stem cells, Transcriptional activator that binds the DNA consensus sequence 5'-ATGCAAAT-3'

Belongs to the POU transcription factor family


This is Homeobox protein NANOG protein, from Chicken, contains 309 amino acids, locates in Nucleus.

Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells


This is Pleurain-A1 protein, from Yunnan pond frog, contains 69 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide, Has activity against the Gram-positive bacterium S,aureus ATCC2592 (MIC=15 ug/ml), the Gram-negative bacteria E,coli ATCC25922 (MIC=60 ug/ml), B,dysenteriae (MIC=120 ug/ml), H,pylori NTCT11637 (MIC=30 ug/ml), and the fungus C,albicans ATCC2002 (MIC=30 ug/ml), Has little hemolytic activity on rabbit red blood cells

Belongs to the frog skin active peptide (FSAP) family, Pleurain subfamily


This is Sodium/sulfate cotransporter 1 protein, from Chlamydomonas smithii, contains 881 amino acids, is membrane-bound, locates in Cell membrane.

Na(+)/sulfate cotransporter with a probable high-affinity for sulfate and a proteasome dependent turnover

Belongs to the divalent anion:Na+ symporter (DASS) superfamily, Na+/sulfate symporter (TC 2,A,47,4) family


This is Proton/sulfate cotransporter 2 protein, from Chlamydomonas smithii, contains 764 amino acids, is membrane-bound, locates in Cell membrane.

H(+)/sulfate cotransporter with a probable high-affinity for sulfate and a proteasome independent turnover

Belongs to the SLC26A/SulP transporter (TC 2,A,53) family


This is Outer dynein arm protein 1 protein, from Chlamydomonas smithii, contains 552 amino acids, is soluble, locates in Cytoplasm.

Component of the outer dynein arm complex required for assembly of the outer dynein arm-docking complex (ODA-DC) and the outer dynein arm onto the doublet microtubule


This is Golgin subfamily A member 8B protein, from Human, contains 603 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in maintaining Golgi structure


This is Exocrine gland-secreted peptide 22 protein, from Mouse, contains 111 amino acids, is soluble, locates in Extracellular.

Pheromone produced by juveniles which activates a small number of vomeronasal organ sensory neurons and exhibits a powerful inhibitory effect on adult male mating behavior

Belongs to the exocrine gland-secreted peptide family


This is Endo-1,4-beta-xylanase S20 protein, from Rumen fungus, contains 335 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is BTB/POZ domain-containing protein 6-A protein, from Zebrafish, contains 540 amino acids, is soluble, locates in Cytoplasm.

Adapter protein for the cul3 E3 ubiquitin-protein ligase complex, Promotes the export of zbtb16/plzf from the nucleus to the cytoplasm and targets zbtb16/plzf for ubiquitination and degradation, Up-regulates neurog1 expression and antagonizes zbtb16/plzf, to promote neurogenesis


This is Protein RRP6-like 3 protein, from Mouse-ear cress, contains 892 amino acids, is soluble, locates in Cytoplasm.


This is Carbonic anhydrase 1 protein, from Rat, contains 261 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the reversible hydration of carbon dioxide

Belongs to the alpha-carbonic anhydrase family


This is TPR repeat-containing protein ZIP4 protein, from Mouse-ear cress, contains 936 amino acids, locates in Nucleus.

Required for meiotic chromosome segregation, It is involved in interference-sensitive crossovers (class I meiotic crossover) formation, in both male and female meiosis, Is specific to recombination events resulting in interference-sensitive crossovers (class I meiotic crossover), Not required for synapsis completion


This is Venom dipeptidyl peptidase 4 protein, from Yellow jacket, contains 776 amino acids, is soluble, locates in Extracellular.

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline, May process venom proteins into their active forms and/or modulate the chemotactic activity of immune cells after the insect sting

Belongs to the peptidase S9B family, DPPIV subfamily


This is Histocompatibility antigen 60b protein, from Mouse, contains 251 amino acids, is membrane-bound, locates in Cell membrane.

Ligand for the KLRK1 immunosurveillance receptor, Binding to KLRK1 stimulates cell lysis in vitro


This is Histocompatibility antigen 60c protein, from Mouse, contains 197 amino acids, is membrane-bound, locates in Cell membrane.


This is Naringenin 8-dimethylallyltransferase 1, chloroplastic protein, from Ku shen, contains 410 amino acids, is membrane-bound, locates in Plastid.

Involved in the biosynthesis of sophoraflavanone G (SFG), Can use flavanones (naringenin, liquiritigenin and hesperetin) as substrates, but not flavonols or isoflavones, Shows a strict specificity for dimethylallyl diphosphate

Belongs to the UbiA prenyltransferase family


This is Antifreeze protein Maxi protein, from Winter flounder, contains 218 amino acids, is soluble, locates in Extracellular.

Contributes to protect fish blood from freezing at subzero sea water temperatures, Lowers the blood freezing point by about 1,1 degrees at a concentration of 0,1 mg/ml, and by about 1,5 degrees at a concentration of 0,2 mg/ml, Binds to nascent ice crystals and prevents further growth


This is Transcription initiation factor TFIID subunit 12b protein, from Mouse-ear cress, contains 681 amino acids, locates in Nucleus.

TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription, Required for the expression of a subset of ethylene-responsive genes (By similarity), Involved in the negative regulation of cytokinin sensitivity


This is Venom dipeptidyl peptidase 4 protein, from Honeybee, contains 775 amino acids, is soluble, locates in Extracellular.

Venom dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline, May process promelittin into its active form and/or modulate the chemotactic activity of immune cells after the insect sting


This is Golgi pH regulator protein, from Chinese hamster, contains 455 amino acids, is membrane-bound, locates in Golgi apparatus.

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance (PubMed:18794847), Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (By similarity)

Belongs to the Golgi pH regulator (TC 1,A,38) family


This is Apyrase protein, from Horsefly, contains 554 amino acids, is soluble, locates in Extracellular.

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host, Shows potential for antithrombotic activity, May reduce probing time by facilitating the speed of locating blood


This is Latartoxin-1a protein, from Spider, contains 85 amino acids, is soluble, locates in Extracellular.

Insect toxin, Causes paralysis in larvae of C,vicina by depolarizing membranes at the neuromuscular junction

Belongs to the neurotoxin 19 (CSTX) family


This is Latartoxin-1b protein, from Spider, contains 86 amino acids, is soluble, locates in Extracellular.


This is Laforin, isoform 9 protein, from Human, contains 344 amino acids, locates in Nucleus.


This is Potassium channel toxin alpha-KTx 16.7 protein, from Mediterranean checkered scorpion, contains 59 amino acids, is soluble, locates in Extracellular.

May play a role in blocking voltage-gated potassium channels Kv1,2/KCNA2, and Kv1,3/KCNA3, Blocks the voltage-gated potassium channel Kv1,3/KCNA3, with an IC(50) of 118,3 +-55,8 nM

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily


This is Lucifensin protein, from Green bottle fly, contains 40 amino acids, is soluble, locates in Extracellular.

Shows strong antibacterial activity against the Gram-positive bacterium M,luteus (PubMed:23802451), Also shows antibacterial activity against the Gram-positive bacteria E,fecalis, S,aureus, S,carnosus, S,pneumoniae and S,pyogenes and against a number of methicillin-resistant S,aureus and glycopeptide-intermediate S,aureus isolates (By similarity), Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C,utilis (By similarity), Shows slight antifungal activity against C,albicans (By similarity)

Belongs to the invertebrate defensin family, Type 1 subfamily


This is MYB-like transcription factor TCL2 protein, from Mouse-ear cress, contains 100 amino acids, locates in Nucleus.

MYB-type transcription factor involved in trichome cell specification, Acts as a negative regulator of trichome patterning and formation, May function by suppressing the expression of GL3


This is Protein REVEILLE 7 protein, from Mouse-ear cress, contains 372 amino acids, locates in Nucleus.

Transcription factor involved in phytochrome A-mediated cotyledon opening, Controlled by the central oscillator mediated by LHY and CCA1, Part of a regulatory circadian feedback loop, Regulates its own expression


This is PHD finger protein ING2 protein, from Mouse-ear cress, contains 262 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes


This is Endo-1,4-beta-xylanase 11A protein, from Noble rot fungus, contains 226 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Required for planr infection and the appearance of secondary lesions


This is AN1-type zinc finger protein 5 protein, from Rat, contains 213 amino acids, has 1 A20-type Zinc finger, has 1 AN1-type Zinc finger, is soluble, locates in Cytoplasm.

Involved in protein degradation via the ubiquitin-proteasome system, May act by anchoring ubiquitinated proteins to the proteasome, Plays a role in ubiquitin-mediated protein degradation during muscle atrophy, Plays a role in the regulation of NF-kappa-B activation and apoptosis, Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA, Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner, Overexpression sensitizes cells to TNF-induced apoptosis, Is a potent inhibitory factor for osteoclast differentiation (By similarity)


This is Preprofallaxidin-2 protein, from Eastern dwarf tree frog, contains 91 amino acids, is soluble, locates in Extracellular.

Fallaxidin-3,2 shows antibacterial activity against the Gram-positive bacteria E,faecalis (MIC=100 uM) and L,lactis (MIC=500 uM), No antibacterial activity against the Gram-positive bacteria B,cereus, L,innocua, M,luteus, S,epidermidis, S,uberis and S,aureus, or the Gram-negative bacteria E,cloacae and E,coli

Belongs to the frog skin active peptide (FSAP) family, Dermaseptin subfamily


This is Preprofallaxidin-1 protein, from Eastern dwarf tree frog, contains 67 amino acids, is soluble, locates in Extracellular.

Fallaxidin-4,1 shows antibacterial activity against the Gram-positive bacteria L,lactis (MIC=12 uM), M,luteus (MIC=100 uM), S,epidermidis (MIC=100 uM) and S,uberis (MIC=50 uM), No antibacterial activity against the Gram-positive bacteria B,cereus, E,faecalis, L,innocua, S,aureus, or the Gram-negative bacteria E,cloacae and E,coli, Inhibits the formation of NO by neuronal nitric oxide synthase with an IC(50) of 13,3 uM

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is Preprofallaxidin-8 protein, from Eastern dwarf tree frog, contains 109 amino acids, is soluble, locates in Extracellular.


This is Preprofallaxidin-9 protein, from Eastern dwarf tree frog, contains 94 amino acids, is soluble, locates in Extracellular.


This is Solute carrier family 52, riboflavin transporter, member 2 protein, from Rat, contains 450 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism, May also act as a receptor for 4-hydroxybutyrate

Belongs to the riboflavin transporter family


This is Phospholipase A2 homolog protein, from Ocellated saw-scaled viper, contains 138 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 homolog that lacks enzymatic activity, Shows high myotoxin activities and displays edema-inducing activities (By similarity), Has cytotoxic activities against HUVEC cells (LC(50)=5,0 uL) and human lung adenocarcinoma A549 cells (LC(50)=5,2 uL)

Belongs to the phospholipase A2 family, Group II subfamily, S49 sub-subfamily


This is Probable exo-1,4-beta-xylosidase xlnD protein, from Aspergillus japonicus, contains 804 amino acids, is soluble, locates in Extracellular.

Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose

Belongs to the glycosyl hydrolase 3 family


This is Secondary metabolism regulator laeA protein, from Penicillium chrysogenum, contains 427 amino acids, locates in Nucleus.

Methyltransferase that performs automethylation (By similarity), No other methyl-accepting substrate has been identified yet (By similarity), Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:18952140, PubMed:22439693), Controls the expression of the penicillin gene cluster (PubMed:18952140, PubMed:20543063, PubMed:22439693, PubMed:23089625, PubMed:23264641), Controls benzylpenicillin production, but is not involved in the biosynthesis of the alkaloid roquefortine C (PubMed:18952140), Positively controls the expression of the class V chitinase chiB1 (PubMed:21816879), Positively controls the expression of the transcription factor atfA (PubMed:25557366), Regulates also asexual differentiation (PubMed:18952140, PubMed:23264641)

Belongs to the methyltransferase superfamily, LaeA methyltransferase family


This is Draxin protein, from Chicken, contains 349 amino acids, is soluble, locates in Extracellular.

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures, Acts as a chemorepulsive guidance protein for commissural axons during development, Able to inhibit or repel neurite outgrowth from dorsal spinal cord and cortical explants in vitro, Binds directly to the neurites and growth cones


This is Peroxisomal adenine nucleotide carrier 1 protein, from Soybean, contains 318 amino acids, is membrane-bound, locates in Peroxisome.

Peroxisomal adenine nucleotide transporter catalyzing the counterexchange of ATP with AMP, ATP is needed by reactions that generate acyl-CoA for peroxisomal fatty acid beta-oxidation during postgerminative growth, Required for the conversion of seed-reserved triacylglycerols into sucrose that is necessary for growth before the onset of photosynthesis

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Endo-1,4-beta-xylanase B protein, from White-rot fungus, contains 290 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose


This is Endo-1,4-beta-xylanase C protein, from White-rot fungus, contains 399 amino acids, is soluble, locates in Extracellular.

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Toxin Pg8 protein, from Granulated thick-tailed scorpion, contains 82 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily


This is Xaa-Pro aminopeptidase 3 protein, from Mouse, contains 506 amino acids, locates in Mitochondrion.

Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala, Also shows low activity towards peptides with Ala or Ser at the P1 position, Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity, May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling


This is NAD-dependent protein deacetylase SRT1 protein, from Rice, contains 483 amino acids, locates in Nucleus.

NAD-dependent protein deacetylase (PubMed:17468215), Has deacetylase activity towards H3K9Ac (PubMed:17468215), May have a function in the safeguard against genome instabiliy and DNA damage to ensure plant cell growth (Probable), May negatively regulate metabolic signal transduction involving methanol and jasmonates during leaf senescence, Required for histone H3K9Ac deacetylation and repression of AP2-1/RSR1 and amylase genes during early seed development, Functions as an epigenetic regulator to repress the expression of glycolytic genes and glycolysis in seedlings, Reduces lysine acetylation of the glycolytic glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is found to also function as an activator of glycolytic gene expression (By similarity)

Belongs to the sirtuin family, Class IV subfamily


This is DNA topoisomerase 6 subunit B protein, from Rice, contains 696 amino acids, locates in Nucleus.

Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles, Relaxes both positive and negative superturns and exhibits a strong decatenase activity, The B subunit binds ATP (By similarity), May be involved in cell proliferation and stress tolerance


This is Hadrucalcin protein, from Scorpion, contains 74 amino acids, is soluble, locates in Extracellular.

This toxin activates ryanodine receptors RyR1 and RyR2 by inducing a long-lasting subconductance state (35% of the full conductance stateon RyR1) (PubMed:19389159, PubMed:27114612), Furthermore, it triggers calcium release from sarcoplasmic vesicles (11,8 nM are enough to induce a sharp release on RyR1, and 55% of the total calcium is released after toxin (100 nM) addition on RyR1) probably by acting as a cell-penetrating peptide (CPP) (PubMed:19389159), In addition, it has been shown to dose-dependently stimulate ryanodine binding to RyR1 (EC(50)=14,8 nM) (PubMed:27114612), It also augments the bell-shaped calcium-[3H]ryanodine binding curve that is maximal at about 10 uM calcium concentration (PubMed:27114612), It binds a different site as ryanodine (By similarity), It acts synergistically with caffeine (PubMed:19389159), In vivo, intracerebroventricular injection into mice induces neurotoxic symptoms, followed by death (By similarity)


This is Santalene and bergamotene synthase, chloroplastic protein, from Wild tomato, contains 777 amino acids, locates in Plastid.

(2Z,6Z)-farnesyl diphosphate cyclizing enzyme, Produces (+)-alpha-santalene, (+)-endo-beta-bergamotene, (-)-endo-alpha-bergamotene, and at lower amounts, (-)exo-alpha-bergamotene and (+)-epi-beta-santalene, Not able to use geranyl diphosphate, E,E-farnesyl diphosphate or E,E,E-geranylgeranyl diphosphate as substrates, but able to use Neryl diphosphate to make the monoterpene terpineol

Belongs to the terpene synthase family, Tpse subfamily


This is Pentatricopeptide repeat-containing protein OGR1, mitochondrial protein, from Rice, contains 587 amino acids, locates in Mitochondrion.

Involved in multiple sites RNA editing events in mitochondria, Essential for C-to-U RNA editing at seven specific sites of nad2, nad4, cox2, cox3 and ccmC transcripts, all coding for proteins involved in the mitochondrial electron transport chain coupled to ATP generation, Required for normal growth and development


This is Acidic phospholipase A2 BlatPLA2 protein, from Side-striped palm pitviper, contains 122 amino acids, is soluble, locates in Extracellular.

Acidic phospholipase A2 (PLA2) that only causes a mild edema, when subcutaneously injected in the mice foot, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is Alpha-elapitoxin-Dpp2d protein, from Black mamba, contains 72 amino acids, is soluble, locates in Extracellular.

Binds with high affinity to muscular (IC(50)=114 nM) and neuronal (alpha-7/CHRNA7) (IC(50)=58 nM) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission, Competitive radioligand binding assays also demonstrate that this toxin competes with epibatidine binding to the Lymnea stagnalis acetylcholine-binding protein (Ls-AChBP) (IC(50)=4,9 nM)

Belongs to the snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily


This is FXYD domain-containing ion transport regulator 11 protein, from Zebrafish, contains 69 amino acids, is membrane-bound, locates in Cell membrane.

May modulate the activity of a sodium/potassium-transporting ATPase


This is Potassium channel toxin alpha-KTx 3.18 protein, from Lesser Asian scorpion, contains 61 amino acids, is soluble, locates in Extracellular.

Inhibits voltage-gated potassium channel rKv1,1/KCNA1 at nanomolar ranges (IC(50)=90 +-2 nM, reduction of current by 30% at 50 nM or toxin)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily


This is Potassium channel toxin alpha-KTx 1.16 protein, from Lesser Asian scorpion, contains 58 amino acids, is soluble, locates in Extracellular.

Inhibits voltage-gated potassium channel rKv1,1/KCNA1 (IC(50)=780-2110 nM), rKv1,2/KCNA2 (IC(50)=0,19 nM), hKv1,3/KCNA3 (IC(50)=67 nM), and rKv1,6/KCNA6 (IC(50)=8,9 uM) (PubMed:25792741, PubMed:30248306), Its activity (tested on Kv1,2) is not voltage-dependent (PubMed:30248306)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 01 subfamily


This is Probable LRR receptor-like serine/threonine-protein kinase At1g06840 protein, from Mouse-ear cress, contains 953 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Probable LRR receptor-like serine/threonine-protein kinase At2g16250 protein, from Mouse-ear cress, contains 915 amino acids, is membrane-bound, locates in Cell membrane.


This is Three-finger toxin W-III protein, from Desert black snake, contains 83 amino acids, is soluble, locates in Extracellular.

Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission

Belongs to the snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily


This is Three finger toxin W-V protein, from Desert black snake, contains 86 amino acids, is soluble, locates in Extracellular.

Three-finger toxin that binds and inhibits the muscular nicotinic acetylcholine receptor (nAChR), The neuromuscular block is irreversible in chick biventer cervicis, but partially reversible in the rat diaphragm preparation

Belongs to the snake three-finger toxin family, Ancestral subfamily, Orphan group II sub-subfamily


This is Alpha-conotoxin Ms20.3 protein, from Weasel cone, contains 94 amino acids, is soluble, locates in Extracellular.

Alpha-D-conopeptides act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them, This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7 (IC(50)=0,12 nM), alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=1,08 nM), and alpha-4-beta-2/CHRNA4-CHRNB2 (IC(50)=4,5 nM) subtypes, Has no effect on alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-4/CHRNA4-CHRNB4 and alpha-1-beta-1-epsilon-delta/CHRNA1-CHRNB1-CHRNE-CHRND subtypes of nAChRs


This is Alpha-conotoxin Cp20.3 protein, from Captain cone, contains 94 amino acids, is soluble, locates in Extracellular.

Alpha-D-conopeptides act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them, This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7 (IC(50)=0,25 nM), alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=2,8 nM), and alpha-4-beta-2/CHRNA4-CHRNB2 (IC(50)=28,6 nM) subtypes, Has no effect on alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-4/CHRNA4-CHRNB4 and alpha-1-beta-1-epsilon-delta/CHRNA1-CHRNB1-CHRNE-CHRND subtypes of nAChRs


This is Sperm head and tail associated protein protein, from Mouse, contains 806 amino acids, is soluble, locates in Cytoplasm.


This is Autophagy-related protein 37 protein, from Yeast, contains 409 amino acids, is membrane-bound, locates in Peroxisome.

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy, Required for both micropexophagy and macropexophagy, but not for the cytoplasm to vacuole transport (Cvt) or autophagy pathways, Required for functional micropexophagic apparatus (MIPA) and relocation of ATG11 to the peroxisome-sequestering arms of the vacuole, Binds palmytoyl-CoA but not oleyl-CoA


This is Natriuretic and helokinestatin peptides protein, from Banded Gila monster, contains 178 amino acids, is soluble, locates in Extracellular.

Natriuretic peptide exhibits vasoactive properties and induces hypotension, possibly by binding to natriuretic peptide receptor NPR1

In the C-terminal section; belongs to the natriuretic peptide family


This is SCF E3 ubiquitin ligase complex F-box protein grrA protein, from Aspergillus nidulans, contains 585 amino acids, is soluble, locates in Cytoplasm.

Involved in meiosis and required for ascospore formation, Involved in substrate recognition in ubiquitin-dependent degradation


This is Antifungal protein B protein, from Penicillium notatum, contains 92 amino acids, is soluble, locates in Extracellular.

Antifungal protein that acts as an inhibitor of growth of human pathogenic molds and yeasts (PubMed:19683356, PubMed:29379111), Is active against the model organism Neurospora crassa, the opportunistic human pathogens Aspergillus fumigatus, Trichophyton rubrum, and Aspergillus terreus (PubMed:29379111), Provokes a reduction of the incidence of infections caused by Penicillium digitatum and Penicillium italicum in oranges and by Penicillium expansum in apples (PubMed:34199956), Low doses of pafB have self-inhibition activity (PubMed:29379111), Shows also activity against the model yeast Saccaromyces cerevisiae and the opportunistic human pathogen Candida albicans (PubMed:35499318, PubMed:29379111), No antibacterial activity is observed on the Gram-negative Escherichia coli and the Gram-positive Bacillus subtilis (PubMed:29379111), Finally, shows also anti-viral activity in a model of HCoV 229E infected L132 cells (PubMed:29379111)

Belongs to the antifungal protein pafB family


This is Sodium/sulfate cotransporter 2 protein, from Chlamydomonas smithii, contains 883 amino acids, is membrane-bound, locates in Cell membrane.

Na(+)/sulfate cotransporter with a probable high-affinity for sulfate and a proteasome dependent turnover

Belongs to the divalent anion:Na+ symporter (DASS) superfamily, Na+/sulfate symporter (TC 2,A,47,4) family


This is MYB-like transcription factor TCL1 protein, from Mouse-ear cress, contains 84 amino acids, locates in Nucleus.

MYB-type transcription factor involved in trichome cell specification, Acts as a negative regulator of trichome patterning and formation by direct binding to the cis-acting regulatory elements of GL1, thus suppressing the expression of GL1


This is Potassium channel toxin alpha-KTx 16.4 protein, from Lesser Asian scorpion, contains 59 amino acids, is soluble, locates in Extracellular.

Weak inhibitor of voltage-gated potassium channel hKv1,3/KCNA3

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 16 subfamily


This is Nuclear GTPase SLIP-GC protein, from Mouse, contains 796 amino acids, locates in Nucleus.

Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (By similarity), Reduces somatic hypermutation in B-cells which may enhance genome stability (PubMed:22833677)


This is Calcium-responsive transcription factor protein, from Rat, contains 587 amino acids, locates in Nucleus.

Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription, Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence


This is Probable mannosyl-oligosaccharide alpha-1,2-mannosidase ARB_00035 protein, from Trichophyton mentagrophytes, contains 509 amino acids, is soluble, locates in Extracellular.

Involved in the maturation of Asn-linked oligosaccharides, Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Belongs to the glycosyl hydrolase 47 family


This is Omega-theraphotoxin-Pm1a protein, from King baboon spider, contains 84 amino acids, is soluble, locates in Extracellular.

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav), This toxin inhibits barium currents (IBa) mediated by L-type voltage-gated calcium channels Cav1,2/CACNA1C (IC(50)=825 nM) and Cav1,3/CACNA1C (IC(50)=2240 nM) (PubMed:24561180)

Belongs to the neurotoxin 10 (Hwtx-1) family, 41 (Jztx-36) subfamily


This is Germacrene A hydroxylase protein, from Chicory, contains 488 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the biosynthesis of germacrene-derived sesquiterpene lactones, Catalyzes three consecutive oxidations of germacrene A to produce germacrene A acid, Could also catalyze the three-step oxidation of non-natural substrate amorphadiene to artemisinic acid, Can use beta-elemene as substrate


This is Apyrase protein, from Asian tiger mosquito, contains 564 amino acids, is soluble, locates in Extracellular.

Facilitates hematophagy by inhibiting ADP-dependent platelet aggregation in the host, May reduce probing time by facilitating the speed of locating blood, Platelet aggregation was inhibited by 6% when 0,4 uM recombinant apyrase was added and by 9,5% when the concentration of recombinant apyrase was 0,8 uM


This is Protein SPT2 homolog protein, from Chicken, contains 690 amino acids, locates in Nucleus.

Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin, Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription, Binds DNA and histones and promotes nucleosome assembly (in vitro) (By similarity), Modulates RNA polymerase 1-mediated transcription (PubMed:23378026), Required for optimal growth in the presence of the DNA damaging agents actinomycin D or mitomycin C (in vitro) (PubMed:23378026), Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity), Modulates RNA polymerase 1-mediated transcription (By similarity), Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity)


This is Kassorin-M protein, from Red-legged running frog, contains 65 amino acids, is soluble, locates in Extracellular.

Induces contraction of smooth muscle in isolated guinea pig urinary bladder (EC50=4,66 nM), Has no antimicrobial activity against the Gram-positive bacterium S,aureus, the Gram-negative bacterium E,coli and the yeast C,albicans, Elicits histamine release from rat peritoneal mast cells

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is Kassorin-S protein, from Senegal running frog, contains 78 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide, Active against the Gram-positive bacterium S,aureus (MIC=30 uM) and the yeast C,albicans (MIC=100 uM), Not effective against the Gram-negative bacterium E,coli at concentrations up to 250 uM, Lacks ability to induce contraction of smooth muscle in isolated guinea pig urinary bladder, Elicits histamine release from rat peritoneal mast cells


This is Toxin Acra3 protein, from Arabian fat-tailed scorpion, contains 84 amino acids, is soluble, locates in Extracellular.

Toxin with unknown target, In vivo, induces severe neurotoxic events in mice such as excitability and convulsions, leading to the death of the animals within a few minutes after injection (PubMed:22819772), Exerts very strong cytotoxic effect on a mouse brain tumor cell line (BC3H1) (IC(50)=5 mg/ml), It exerts its effects by inducing a stronger necrosis than apoptosis in BC3H1 cells (PubMed:24055552)

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Endo-1,4-beta-xylanase B protein, from Penicillium oxalicum, contains 310 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Hydrolyzes birchwood xylan, beechwood xylan, and oat spelt xylan to produce short-chain xylooligosaccharides, xylopentaose, xylotriose, and xylobiose as the main products

Belongs to the glycosyl hydrolase 11 (cellulase G) family


This is Brevinin-1HN1 protein, from Odor frog, contains 71 amino acids, is soluble, locates in Extracellular.

Has antimicrobial activity against Gram-positive bacteria and fungi but has weak or no activity against a range of Gram-negative bacteria except P,faecalis, Active against the Gram-positive bacteria E,faecium 091299 (MIC=19 uM), E,faecalis 981 (MIC=19 uM), S,aureus ATCC 25923 (MIC=1,2 uM), S,carnosus KHS (MIC=4,8 uM), B,licheniformis X39 (MIC=2,4 uM) and R,rhodochrous X15 (MIC=1,2 uM), Active against the Gram-negative bacterium P,faecalis X29 (MIC=4,8 uM), is virtually inactive against E,coli ATCC 25922 (MIC=150 uM) and inactive against P,aeruginosa and S,typhi, Has antifungal activity against C,albicans ATCC 2002 (MIC=2,4 uM) and is also active against the slime mold 090223 (MIC=1,2 uM), Has low hemolytic activity against human erythrocytes (LC(50)=75 uM)


This is GTP:AMP phosphotransferase, mitochondrial protein, from Baker's yeast, contains 234 amino acids, is soluble, locates in Mitochondrion.

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates, Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities, Does not accept ATP as phosphate donor

Belongs to the adenylate kinase family, AK3 subfamily


This is Chondroadherin-like protein protein, from Mouse, contains 748 amino acids, is soluble, locates in Extracellular.

Potential negative modulator of chondrocyte differentiation, Inhibits collagen fibrillogenesis in vitro, May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment

Belongs to the small leucine-rich proteoglycan (SLRP) family, SLRP class IV subfamily


This is Acyl-acyl carrier protein thioesterase ATL4, chloroplastic protein, from Mouse-ear cress, contains 188 amino acids, locates in Plastid.

Acyl-ACP thioesterase involved in the production of fatty acids and beta-keto fatty acids, Can produce fatty acids of medium to long chain (6:0, 8:0, 10:0 and 16:1) and small amounts of medium to long chain beta-keto fatty acids (8:0, 14:0 and 16:1) when expressed in a heterologous organism (E,coli), Possesses thioesterase activity for lauroyl-ACP (12:0-ACP) in vitro, May play a role in the development of floral organs by generating short chain fatty acids

Belongs to the 4-hydroxybenzoyl-CoA thioesterase family


This is NAC domain-containing protein 10 protein, from Mouse-ear cress, contains 314 amino acids, locates in Nucleus.

Transcriptional activator that plays a regulatory role in the development of secondary cell wall fibers, Is a direct target of SND1


This is Cold-regulated 413 inner membrane protein 2, chloroplastic protein, from Mouse-ear cress, contains 226 amino acids, is membrane-bound, locates in Plastid.

Belongs to the Cold-regulated 413 protein family


This is Seipin-2 protein, from Mouse-ear cress, contains 526 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size, Supports the formation of small-sized LDs and modulates triacylglycerol accumulation, Induces probably a reorganization of the endoplasmic reticulum into LD-forming domains


This is Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 1, mitochondrial protein, from Mouse-ear cress, contains 326 amino acids, locates in Mitochondrion.

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell, Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential)


This is Probable UDP-3-O-acyl-N-acetylglucosamine deacetylase 5, mitochondrial protein, from Mouse-ear cress, contains 326 amino acids, locates in Mitochondrion.


This is Probable lipid-A-disaccharide synthase, mitochondrial protein, from Mouse-ear cress, contains 460 amino acids, locates in Mitochondrion.

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell, Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential)


This is Transcription termination factor MTERF2, chloroplastic protein, from Mouse-ear cress, contains 641 amino acids, locates in Plastid.

Transcription termination factor involved in processing of plastid transcripts (By similarity), Essential for embryogenesis (PubMed:15266054)


This is AUGMIN subunit 1 protein, from Mouse-ear cress, contains 299 amino acids, is soluble, locates in Cytoplasm.

Involved in microtubules reorganization during spindle and phragmoplast development


This is tRNA(His) guanylyltransferase 1 protein, from Mouse-ear cress, contains 567 amino acids, is soluble, locates in Nucleus.

Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage

Belongs to the tRNA(His) guanylyltransferase family


This is tRNA(His) guanylyltransferase 2 protein, from Mouse-ear cress, contains 537 amino acids, is soluble, locates in Nucleus.


This is Transmembrane emp24 domain-containing protein p24delta6 protein, from Mouse-ear cress, contains 217 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in vesicular protein trafficking, Mainly functions in the early secretory pathway, Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity)


This is Probable UDP-3-O-acylglucosamine N-acyltransferase 1, mitochondrial protein, from Mouse-ear cress, contains 330 amino acids, locates in Mitochondrion.

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell, Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses

Belongs to the transferase hexapeptide repeat family, LpxD subfamily


This is Probable UDP-3-O-acylglucosamine N-acyltransferase 2, mitochondrial protein, from Mouse-ear cress, contains 304 amino acids, locates in Mitochondrion.


This is Protein NEN4 protein, from Mouse-ear cress, contains 255 amino acids, locates in Nucleus.

Probable exonuclease required for enuclation of sieve elements


This is Formyltetrahydrofolate deformylase 2, mitochondrial protein, from Mouse-ear cress, contains 328 amino acids, locates in Mitochondrion.

Deformylase involved in photorespiration, Prevents excessive accumulation of 5-formyl tetrahydrofolate (THF), a potent inhibitor of the Gly decarboxylase/Ser hydroxymethyltransferase complex


This is TITAN-like protein protein, from Mouse-ear cress, contains 421 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 2; degenerate

Key regulator for endosperm and embryo nuclear divisions


This is Protein DETOXIFICATION 35 protein, from Mouse-ear cress, contains 488 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Multidrug and toxin efflux transporter involved in flavonoid metabolism, Required for proper reproductive development

Belongs to the multi antimicrobial extrusion (MATE) (TC 2,A,66,1) family


This is Protein NETWORKED 4A protein, from Mouse-ear cress, contains 558 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Plant-specific actin binding protein, Associates with F-actin at the tonoplast, May be part of a membrane-cytoskeletal adapter complex


This is Carboxyl-terminal-processing peptidase 1, chloroplastic protein, from Mouse-ear cress, contains 489 amino acids, locates in Plastid.

Protease involved in the C-terminal processing of the chloroplastic D1 protein of photosystem II, This proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation


This is Kinesin-like protein KIN-1 protein, from Rice, contains 477 amino acids, is soluble, locates in Cytoplasm.

Kinesin-like motor protein that exhibits microtubule-stimulated ATPase activity, Plays an essential role in male meiotic chromosomal dynamics, male gametogenesis and anther dehiscence, May play a minor and nonessential role in regulating meiotic spindle formation

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIN-1 subfamily


This is Kasstasin protein, from Red-legged running frog, contains 68 amino acids, is soluble, locates in Extracellular.

Peptide with potent vasoconstrictor properties (EC50=25 pM), Has moderate antimicrobial activity against Gram-positive bacterium S,aureus (MIC=55 uM) and against Gram-negative bacterium E,coli (MIC=110 uM), Not active against fungus C,albicans, Has weak hemolytic activity against horse erythrocytes


This is Jindongenin-1a protein, from Chinese torrent frog, contains 66 amino acids, is soluble, locates in Extracellular.

Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria, Also displays antifungal activity against C,albicans ATCC 2002, Has low hemolytic activity, low cytotoxicity and low antioxidant activity


This is Palustrin-2AJ1 protein, from Chinese torrent frog, contains 71 amino acids, is soluble, locates in Extracellular.

Displays broad-spectrum antibacterial activity against a range of Gram-positive and Gram-negative bacteria, Has low hemolytic activity, low cytotoxicity and low antioxidant activity


This is Endoglucanase 1 protein, from Rice blast fungus, contains 424 amino acids, is soluble, locates in Extracellular.

Endoglucanase that is involved in the biological conversion of cellulose to glucose, Hydrolyses internal beta-1,4-glucosidic bonds

Belongs to the glycosyl hydrolase 7 (cellulase C) family


This is Homeobox protein ceh-2 protein, from Caenorhabditis elegans, contains 209 amino acids, locates in Nucleus.

Required for activity of the M3 pharyngeal motor neuron


This is Mitochondrial genome maintenance protein MGM101 protein, from Yeast, contains 266 amino acids, is soluble, locates in Mitochondrion.

Plays a role in the replication of the mitochondrial genome and the maintenance of its telomeres (PubMed:26743001), Able to catalyze strand annealing and D-loop formation (PubMed:26743001), Binds a wide variety of DNA substrates (PubMed:26743001), Exhibited the highest affinity for DNA molecules carrying 3' ssDNA overhangs (Y-form, 3' FLAP, 3' overhang) and for substrates with complex structures (X-O and Fork) (PubMed:26743001), Forms homogeneous ring-shaped structures at the ssDNA native telomeres ends (PubMed:26743001), Oligomers seem to bind to the ssDNA as a filament until they reach the double-stranded region and induce the formation of bends and loops within the double-stranded part of the molecules (PubMed:26743001)


This is Wings apart-like protein homolog 1 protein, from Caenorhabditis elegans, contains 748 amino acids, locates in Nucleus.

Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis (PubMed:26841696), Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene nuclei (PubMed:26841696), Required for the removal of the cohesin component scc-1 from mitotic chromosomes (PubMed:18202360)


This is piRNA biogenesis protein EXD1 protein, from Silk moth, contains 315 amino acids, is soluble, locates in Cytoplasm.

RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis, The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity, The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs, In the PET complex, EXD1 probably acts as an RNA adapter, EXD1 is an inactive exonuclease


This is Endo-1,4-beta-xylanase 1 protein, from Wheat head blight fungus, contains 354 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Plays an important role in causing fusarium head blight (FHB) on cereal crops

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Endo-1,4-beta-xylanase A protein, from Wheat head blight fungus, contains 231 amino acids, is soluble, locates in Extracellular.


This is Fatty acid hydroperoxide lyase, chloroplastic protein, from Tomato, contains 476 amino acids, is membrane-bound, locates in Plastid.

Cytochrome P450 of the CYP74B subfamily involved in the biosynthesis of traumatin and C6 aldehydes (PubMed:10923789, PubMed:10859201), Metabolizes 13- but not 9-hydroperoxides of linoleic and linolenic acids (PubMed:10923789, PubMed:10859201), Can use 15S-hydroperoxy-11(Z),13(E),17(Z)-eicosatrienoic acid (15-HPET) and 13S-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid (13-HPOT) as substrates, but only 5% activity with 13S-hydroperoxy-9(Z),11(E)-octadecadienoic acid (13-HPOD) (PubMed:10859201), Produces n-hexanal and 12-oxo-9(Z)-dodecanoic acid from 13-HPOD (PubMed:10923789)


This is Three-finger toxin A1 protein, from Balsas coral snake, contains 81 amino acids, is soluble, locates in Extracellular.

Binds and inhibits fetal (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND, IC(50)=1,4 nM), adult (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE, IC(50)=12 nM) and neuronal alpha-7/CHRNA7 (IC(50)=400 nM) nicotinic acetylcholine receptors (nAChR) thereby impairing neuromuscular and neuronal transmissions

Belongs to the snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily


This is Senegalin protein, from Senegal running frog, contains 76 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide with activity against the Gram-positive bacterium S,aureus NCTC 10788 (MIC=50 um) and the yeast C,albicans NCPF 1467 (MIC=150 uM), Ineffective against the Gram-negative bacterium E,coli NCTC 10418, Induces a dose-dependent contraction of rat urinary bladder smooth muscle (EC50=2,9 nM) and a dose-dependent relaxation of rat tail artery smooth muscle (EC50=37,7 nM)


This is Subtilisin-like protease 2 protein, from Bat white-nose syndrome fungus, contains 400 amino acids, is soluble, locates in Extracellular.

Major secreted subtilisin-like serine endopeptidase, Preferentially cleaves substrates containing hydrophobic residues at P4, positively charged residues at P3, small or flexible residues at P2, and large, bulky residues at P1, Mediates the degradation of collagen, the major structural protein in the mammalian host, Degrades the nonhelical regions of collagen that function in the cross-linking of the helical components (PubMed:25944934), May function as virulence factor involved in epidermal wing necrosis observed in white nose syndrome (WNS) in bats (By similarity)


This is Sodium channel alpha-toxin Acra4 protein, from Arabian fat-tailed scorpion, contains 65 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission, Electrophysiological studies of this were performed using sodium-channels expressed in F11 cell culture, by patch-clamp recordings, Affinity of this toxin toward sodium channels in F11 cell line is in the order of 1 uM concentration

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily


This is Sodium/hydrogen exchanger 3 protein, from Banded houndshark, contains 832 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane Na(+)/H(+) antiporter, Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis, Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2,A,36) family


This is Suppressyn protein, from Human, contains 160 amino acids, is soluble, locates in Extracellular.

May play a role in trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development, May negatively regulate cell-cell fusion by interacting with SLC1A5, the probable receptor on the cell surface of the fusogenic syncytin-1/ERVW-1


This is T-box transcription factor 18 protein, from Caenorhabditis elegans, contains 376 amino acids, locates in Nucleus.

Transcriptional regulator involved in developmental processes (PubMed:16139225, PubMed:23666922), Directly binds to the promoter region of the sex-determining factor xol-1 to activate its transcription (PubMed:16139225, PubMed:23666922), Its activation of xol-1 transcription controls sex determination and X chromosome dosage compensation to promote male development (PubMed:23666922), Has a role in the fox-1-sex-1-mediated determination of sexual fate (PubMed:21471153)


This is GPI mannosyltransferase pigv-1 protein, from Caenorhabditis elegans, contains 672 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis (By similarity), Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity), Required for maintenance of epithelial integrity during embryogenesis (PubMed:25807459)


This is Cation/calcium exchanger 5 protein, from Mouse-ear cress, contains 546 amino acids, is membrane-bound, locates in Cell membrane.

Membrane-localized H(+)-dependent K(+) and Na(+) transporter

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family, Cation/calcium exchanger (CCX) subfamily


This is Flowering time control protein FCA protein, from Mouse-ear cress, contains 747 amino acids, locates in Nucleus.

Plays a major role in the promotion of the transition of the vegetative meristem to reproductive development, Plays a role in the regulation of flowering time in the autonomous flowering pathway by decreasing FLOWERING LOCUS C mRNA levels, Required for RNA-mediated chromatin silencing of a range of loci in the genome, Cotranscriptionally recognizes aberrant RNA and marks it for silencing, Controls alternative cleavage and polyadenylation on pre-mRNAs and antisense RNAs, Acts redundantly with FPA to prevent the expression of distally polyadenylated antisense RNAs at the FLC locus


This is Formin-like protein 8 protein, from Mouse-ear cress, contains 760 amino acids, is membrane-bound, locates in Cell membrane.

Might be involved in the organization and polarity of the actin cytoskeleton, Interacts with the barbed end of actin filaments and nucleates actin-filament polymerization in vitro

Belongs to the formin-like family, Class-I subfamily


This is Golgi SNAP receptor complex member 1 protein, from Chinese hamster, contains 250 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport, It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor, May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14), Participates in docking and fusion stage of ER to cis-Golgi transport, Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi


This is GTP-binding protein 1 protein, from Mouse, contains 668 amino acids, is soluble, locates in Cytoplasm.

Promotes degradation of target mRNA species, Plays a role in the regulation of circadian mRNA stability, Binds GTP and has GTPase activity (By similarity)

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, GTPBP1 subfamily


This is Nuclear pore complex protein Nup50 protein, from Rat, contains 467 amino acids, is membrane-bound, locates in Nucleus.

Component of the nuclear pore complex that has a direct role in nuclear protein import, Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling, Interacts with regulatory proteins of cell cycle progression including CDKN1B, This interaction is required for correct intracellular transport and degradation of CDKN1B


This is Zinc finger matrin-type protein 3 protein, from Rat, contains 289 amino acids, has 3 Matrin-type Zinc finger, locates in Nucleus.

Matrin-type

Matrin-type

Matrin-type

Acts as a bona fide target gene of p53/TP53, May play a role in the TP53-dependent growth regulatory pathway, May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus


This is DNA-binding protein Ikaros protein, from Rainbow trout, contains 522 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Binds and activates the enhancer (delta-A element) of the CD3-delta gene, Functions in the specification and the maturation of the T-lymphocyte, Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development, Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity)

Belongs to the Ikaros C2H2-type zinc-finger protein family


This is Ubiquinone biosynthesis protein COQ4, mitochondrial protein, from Baker's yeast, contains 335 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the coenzyme Q biosynthetic pathway, May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis, Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides


This is THO complex subunit THP2 protein, from Baker's yeast, contains 261 amino acids, locates in Nucleus.

Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export, The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription, THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase, It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA


This is Factor arrest protein 11 protein, from Fission yeast, contains 817 amino acids, locates in Lysosome/Vacuole.

Participates in the control of the reentry into the cell cycle following pheromone treatment


This is Integral inner nuclear membrane protein ima1 protein, from Fission yeast, contains 615 amino acids, is membrane-bound, locates in Nucleus.

Inner nuclear membrane protein that specifically binds to heterochromatic regions and promotes the tethering of centromeric DNA to the SUN-KASH complex, Couples centromeres to the nuclear envelope, thus contributing to their association with the microtubule organizing center attachment site and to the positioning of the nucleus at the cell center by microtubules


This is Glycerol dehydrogenase 1 protein, from Fission yeast, contains 450 amino acids, locates in Mitochondrion.

Glycerol dehydrogenase involved in the assimilation of glycerol

Belongs to the iron-containing alcohol dehydrogenase family


This is Transcription initiation factor TFIID subunit 12 protein, from Fission yeast, contains 450 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK, Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription, SAGA is involved in RNA polymerase II-dependent transcriptional regulation, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation, SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3 (By similarity)


This is Alpha-actinin-like protein 1 protein, from Fission yeast, contains 621 amino acids, is soluble, locates in Cytoplasm.

Binds to actin and is involved in actin-ring formation and organization, Plays a role in cytokinesis and is involved in septation


This is ATP-dependent RNA helicase uap56 protein, from Fission yeast, contains 434 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus, SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly, May be involved in rDNA and telomeric silencing, and maintenance of genome integrity, Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC)

Belongs to the DEAD box helicase family, DECD subfamily


This is Probable rRNA-processing protein ebp2 protein, from Fission yeast, contains 333 amino acids, locates in Nucleus.

Required for the processing of the 27S pre-rRNA


This is U1 small nuclear ribonucleoprotein 70 kDa homolog protein, from Fission yeast, contains 261 amino acids, locates in Nucleus.

Involved in nuclear mRNA splicing (By similarity), Essential for growth


This is Oxysterol-binding protein homolog C23H4.01c protein, from Fission yeast, contains 945 amino acids, is soluble, locates in Cytoplasm.


This is Aconitate hydratase, mitochondrial protein, from Fission yeast, contains 789 amino acids, locates in Mitochondrion.

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle

Belongs to the aconitase/IPM isomerase family


This is Protein zds1 protein, from Fission yeast, contains 938 amino acids, is soluble, locates in Cytoplasm.

Has a role in establishing cell polarity, Also required for maintenance of cell wall integrity, sexual differentiation, calcium tolerance and cell morphology, Involved in Ras-MAPK signaling pathway at cell cortex, Has a role in meiosis


This is Transgelin protein, from Fission yeast, contains 174 amino acids, is soluble, locates in Cytoplasm.

Has actin-binding and actin-bundling activity and is a component of the actin patch, Stabilizes actin filaments against disassembly, Cross-links F-actin and is required for the formation of the contractile F-actin ring


This is Iron-sulfur clusters transporter atm1, mitochondrial protein, from Fission yeast, contains 693 amino acids, is membrane-bound, locates in Mitochondrion.

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by nfs1 and other mitochondrial proteins (PubMed:16306692), Hydrolyzes ATP (By similarity), Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity)

Belongs to the ABC transporter superfamily, ABCB family, Heavy Metal importer (TC 3,A,1,210) subfamily


This is Large ribosomal subunit protein P2C protein, from Fission yeast, contains 110 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein P1/P2 family


This is Inosine-5'-monophosphate dehydrogenase protein, from Fission yeast, contains 524 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth


This is Large ribosomal subunit protein eL36B protein, from Baker's yeast, contains 100 amino acids, is soluble, locates in Cytoplasm.

Belongs to the eukaryotic ribosomal protein eL36 family


This is Large ribosomal subunit protein bL36m protein, from Baker's yeast, contains 93 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:24675956), bL36m may be involved in a process influencing telomere capping (PubMed:18845848, PubMed:20691087)

Belongs to the bacterial ribosomal protein bL36 family


This is Transcription factor SOX-12 protein, from Human, contains 315 amino acids, locates in Nucleus.

Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (By similarity), Acts as a transcriptional activator (By similarity), Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (By similarity), Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (By similarity), Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (By similarity), Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (By similarity)


This is GTP-binding nuclear protein ran-1 protein, from Caenorhabditis elegans, contains 215 amino acids, locates in Nucleus.

Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport, Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules, Plays a crucial role in nuclear envelope assembly at the end of each cell division, Required for the import of protein into the nucleus and also for RNA export, RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA

Belongs to the small GTPase superfamily, Ran family


This is Pentatricopeptide repeat-containing protein At2g45350, chloroplastic protein, from Mouse-ear cress, contains 613 amino acids, locates in Plastid.

Plays a major role in chloroplast RNA editing, Acts as a site-recognition transacting factor to recruit C-deaminase (PubMed:15662426, PubMed:17015439), Involved in single RNA editing events, Required for the edition of the site 1 of ndhD (ndhD-1 site corresponding to cytidine-2), which is a plastid-encoded subunit of the NADH-plastoquinone oxidoreductase, The interaction with DYW1 is required for its function in editing the ndhD-1 site (PubMed:23001034)

Belongs to the PPR family, PCMP-E subfamily


This is Protein ARABIDILLO 1 protein, from Mouse-ear cress, contains 930 amino acids, locates in Nucleus.

Promotes lateral root initiation and development, independently of auxin (IAA) and abscisis acid (ABA)


This is Protein MIZU-KUSSEI 1 protein, from Mouse-ear cress, contains 297 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a role in lateral root development by maintaining auxin levels, This function requires GNOM (GN/MIZ2) activity, Negatively regulates cytokinin sensitivity on root development, Positively regulates hydrotropism in roots


This is Zinc finger protein ZAT6 protein, from Mouse-ear cress, contains 238 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Probable transcription factor that regulates root development and phosphate (Pi) acquisition and homeostasis, Probably acts as a repressor of primary root growth and regulates Pi homeostasis through the control of root architecture


This is Peptidyl-prolyl cis-trans isomerase FKBP16-3, chloroplastic protein, from Mouse-ear cress, contains 223 amino acids, locates in Plastid.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)


This is Cation/H(+) symporter 13 protein, from Mouse-ear cress, contains 831 amino acids, is membrane-bound, locates in Cell membrane.

High-affinity potassium transporter that plays a role in K(+) acquisition, May operate as a K(+)/H(+) symporter

Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2,A,37) family, CHX (TC 2,A,37,4) subfamily


This is Insulin-degrading enzyme-like 1, peroxisomal protein, from Mouse-ear cress, contains 970 amino acids, locates in Peroxisome.

Peptidase that might be involved in pathogen or wound response, Not required for peroxisome biogenesis, indole-3-butyric acid (IBA) metabolism, fatty acid beta-oxidation or degradation of glyoxylate cycle enzymes during seedling development


This is Ent-kaurenoic acid oxidase 1 protein, from Mouse-ear cress, contains 490 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes three successive oxidations of ent-kaurenoic acid giving gibberellin 12 (GA12), a key step in gibberellins (GAs) biosynthesis, GAs, which are involved many processes, including stem elongation, play a central role in plant development


This is Cytochrome c-1 protein, from Mouse-ear cress, contains 114 amino acids, is soluble, locates in Mitochondrion.

Electron carrier protein, The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase, Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity)


This is Inositol transporter 4 protein, from Mouse-ear cress, contains 582 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane inositol-proton symporter, Mediates high-affinity myoinositol-proton symport across the plasma membrane, Active with myoinositol, scylloinositol and D-chiroinositol, Low activity with mucoinositol and alloinositol

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family


This is Carboxyl-terminal-processing peptidase 2, chloroplastic protein, from Mouse-ear cress, contains 515 amino acids, locates in Plastid.

Protease involved in the C-terminal processing of the chloroplastic D1 protein of photosystem II, This proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation


This is Protoporphyrinogen oxidase, chloroplastic protein, from Common tobacco, contains 548 amino acids, locates in Plastid.

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX

Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family, Protoporphyrinogen oxidase subfamily


This is DNA-directed RNA polymerase 3, chloroplastic protein, from Mouse-ear cress, contains 993 amino acids, locates in Plastid.

Nuclear-encoded DNA-dependent RNA polymerase that catalyzes the transcription of DNA into RNA in chloroplasts using the four ribonucleoside triphosphates as substrates (Probable), Required for chloroplast development and leaf mesophyll cell proliferation (PubMed:16698900)

Belongs to the phage and mitochondrial RNA polymerase family


This is Aspartyl aminopeptidase 1 protein, from Fission yeast, contains 467 amino acids, is soluble, locates in Cytoplasm.

Aspartyl aminopeptidase that is able to remove aspartyl residue at N-terminus of angiotensin I, Acts also as a chaperone and efficiently suppressed the thermal aggregation of citrate synthase


This is Inner kinetochore subunit fta1 protein, from Fission yeast, contains 280 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly


This is MYND-type zinc finger protein samB protein, from Aspergillus nidulans, contains 590 amino acids, has 1 MYND-type; degenerate Zinc finger, is soluble, locates in Cytoplasm.

MYND-type; degenerate

Involved in determination of the onset of polarized growth and morphogenesis, Plays a role in the regulation of branching in hyphae and spore formation


This is Serine/threonine-protein kinase rio1 protein, from Fission yeast, contains 497 amino acids, is soluble, locates in Cytoplasm.

Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA, Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit, Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity)

Belongs to the protein kinase superfamily, RIO-type Ser/Thr kinase family


This is Aspartate aminotransferase, cytoplasmic protein, from Fission yeast, contains 409 amino acids, is soluble, locates in Cytoplasm.

Plays a key role in amino acid metabolism

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is Uba3-binding protein but1 protein, from Fission yeast, contains 243 amino acids, locates in Nucleus.

Acts as a negative regulator of the NEDD8 pathway, Has a role in meiosis


This is Copper amine oxidase-like protein cao2 protein, from Fission yeast, contains 794 amino acids, is soluble, locates in Cytoplasm.

Copper amine oxidase-like protein that does not show any copper amine oxidase activity, May be the appropriate amine substrate for cao2 has not been identified yet

Belongs to the copper/topaquinone oxidase family


This is Pre-mRNA-processing factor 31 protein, from Fission yeast, contains 518 amino acids, locates in Nucleus.

Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes


This is Dolichyl-phosphate-mannose--protein mannosyltransferase 4 protein, from Fission yeast, contains 778 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins, Required for normal cell wall and septum formation

Belongs to the glycosyltransferase 39 family


This is Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43 protein, from Fission yeast, contains 735 amino acids, locates in Nucleus.

Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA

Belongs to the DEAD box helicase family, DEAH subfamily, DDX15/PRP43 sub-subfamily


This is NEDD8-specific protease 1 protein, from Fission yeast, contains 420 amino acids, is soluble, locates in Cytoplasm.

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins


This is RNA polymerase II degradation factor 1 protein, from Fission yeast, contains 963 amino acids, is soluble, locates in Cytoplasm.

Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor rhp26 fails to efficiently displace stalled RNA polymerase II, Also involved in telomere length regulation, Binds DNA


This is Serine/threonine-protein kinase ppk30 protein, from Fission yeast, contains 953 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is ATPase-like fidgetin protein, from Fission yeast, contains 660 amino acids, locates in Nucleus.


This is Histone promoter control protein 2 protein, from Fission yeast, contains 338 amino acids, locates in Nucleus.

Component of the HIR complex, which functions as a histone chaperone that cooperates with cia1/asf1 to promote replication-independent chromatin assembly


This is Double homeobox protein 1 protein, from Human, contains 170 amino acids, locates in Nucleus.

Probable transcription activator, Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'


This is Facilitated glucose transporter protein 1 protein, from Caenorhabditis elegans, contains 510 amino acids, is membrane-bound, locates in Cell membrane.

Facilitative glucose transporter that plays a role in glucose metabolism and regulation of longevity, May also play a role in lipid metabolism, Glucose transport activity of isoform a is competitively inhibited by mannose, galactose and fructose, suggesting ability to transport also other hexose sugars

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Glucose transporter subfamily


This is U1-agatoxin-Ta1c protein, from Hobo spider, contains 68 amino acids, is soluble, locates in Extracellular.

Toxin that paralyzes insects, May have a direct effect on the insect central nervous system

Belongs to the helical arthropod-neuropeptide-derived (HAND) family


This is Formin-like protein 4 protein, from Mouse-ear cress, contains 763 amino acids, is membrane-bound, locates in Cell membrane.

Might be involved in the organization and polarity of the actin cytoskeleton

Belongs to the formin-like family, Class-I subfamily


This is Suppressor of mec-8 and unc-52 protein homolog 2 protein, from Mouse-ear cress, contains 585 amino acids, locates in Nucleus.

Auxiliary spliceosomal protein involved in splicing of specific pre-mRNAs that affect multiple aspects of development


This is Uroporphyrinogen-III synthase, chloroplastic protein, from Mouse-ear cress, contains 321 amino acids, locates in Plastid.

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, a precursor of tetrapyrroles such as chlorophyll, heme and phycobilins

Belongs to the uroporphyrinogen-III synthase family


This is Protein WEAK CHLOROPLAST MOVEMENT UNDER BLUE LIGHT 1 protein, from Mouse-ear cress, contains 807 amino acids, is soluble, locates in Cytoplasm.

Required for the chloroplast avoidance response under high intensity blue light, This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells, Acts in association with PMI2 to maintain the velocity of chloroplast photorelocation movement via cp-actin filaments regulation


This is Protein argonaute 6 protein, from Mouse-ear cress, contains 878 amino acids, locates in Nucleus.

Involved in transcriptional gene silencing (TGS), Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats, Required for the accumulation of specific siRNAs derived from transgene and heterochromatin-related endogenous loci, Involved in RNA-directed DNA methylation (RdDM) at specific endogenous loci, Probably not required for the accumulation of siRNAs derived from transgene inverted repeats that induce post-transcriptional gene silencing (PTGS), Associates mainly with small RNAs of 24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine, Targeted by turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO6 function in RNA silencing

Belongs to the argonaute family, Ago subfamily


This is Leucine-rich repeat extensin-like protein 2 protein, from Mouse-ear cress, contains 786 amino acids, is soluble, locates in Extracellular.

Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization, Together with LRX2, component of the extracellular mechanism regulating root hair morphogenesis and elongation


This is PsbP domain-containing protein 4, chloroplastic protein, from Mouse-ear cress, contains 260 amino acids, locates in Plastid.


This is Vesicle-associated membrane protein 711 protein, from Mouse-ear cress, contains 219 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Involved in the targeting and/or fusion of transport vesicles to their target membrane


This is NAC domain-containing protein 73 protein, from Mouse-ear cress, contains 305 amino acids, locates in Nucleus.

Transcriptional activator that plays a regulatory role in the development of secondary cell wall fibers (PubMed:18952777, PubMed:22133261), Involved in the regulation of cellulose and hemicellulose biosynthetic genes as well as of genes involved in lignin polymerization and signaling (PubMed:22133261), Is not a direct target of SND1 (PubMed:18952777)


This is 9-cis-epoxycarotenoid dioxygenase NCED2, chloroplastic protein, from Mouse-ear cress, contains 583 amino acids, is soluble, locates in Plastid.

Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity, Catalyzes the first step of abscisic-acid biosynthesis from carotenoids

Belongs to the carotenoid oxygenase family


This is Glycolate oxidase 3 protein, from Mouse-ear cress, contains 368 amino acids, locates in Peroxisome.

Catalyzes the oxidation of glycolate to glyoxylate, with a reduction of O2 to H2O2, Is a key enzyme in photorespiration in green plants

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family


This is Probable plastid-lipid-associated protein 2, chloroplastic protein, from Mouse-ear cress, contains 310 amino acids, is soluble, locates in Plastid.

Probably involved in light/cold stress-related jasmonate (JA) biosynthesis


This is Protein PAM68, chloroplastic protein, from Mouse-ear cress, contains 214 amino acids, is membrane-bound, locates in Plastid.

Involved in early steps in photosystem II (PSII) biogenesis and in maturation and stability of newly synthesized psbA protein


This is Probable carotenoid cleavage dioxygenase 4, chloroplastic protein, from Mouse-ear cress, contains 595 amino acids, is soluble, locates in Plastid.


This is Outer envelope pore protein 24, chloroplastic protein, from Garden pea, contains 213 amino acids, is membrane-bound, locates in Plastid.

High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids

Belongs to the plastid outer envelope porin OEP24 (TC 1,B,28) family


This is Protein TIC 55, chloroplastic protein, from Garden pea, contains 553 amino acids, is membrane-bound, locates in Plastid.

Involved in protein precursor import into chloroplasts, Part of the redox regulon consisting of TIC32, TIC 55 and TIC62


This is Transthyretin protein, from Saltwater crocodile, contains 150 amino acids, is soluble, locates in Extracellular.

Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4), Probably transports triiodothyronine from the bloodstream to the brain


This is Copper-transporting ATPase ccc2 protein, from Fission yeast, contains 904 amino acids, is membrane-bound, locates in Golgi apparatus.

Probably involved in copper transport and in the regulation of cellular copper level, Retrieves copper from the metallochaperone atx1 and incorporates it into trans-Golgi vesicles (By similarity)

Belongs to the cation transport ATPase (P-type) (TC 3,A,3) family, Type IB subfamily


This is Small ribosomal subunit protein uS4B protein, from Fission yeast, contains 192 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel, uS4 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly

Belongs to the universal ribosomal protein uS4 family


This is Rho guanine nucleotide exchange factor gef3 protein, from Fission yeast, contains 525 amino acids, is soluble, locates in Cytoplasm.

Has a role in the control of cell polarity and cytokinesis, Involved in bipolar growth and septum formation


This is Cytochrome c1, heme protein, mitochondrial protein, from Fission yeast, contains 307 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation, The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase, The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol, In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c, Cytochrome c1 is a catalytic core subunit containing a c-type heme, It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c


This is Chromatin modification-related protein vid21 protein, from Fission yeast, contains 994 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair (By similarity)


This is ATP-dependent zinc metalloprotease YME1 homolog protein, from Fission yeast, contains 709 amino acids, is membrane-bound, locates in Mitochondrion.

In the C-terminal section; belongs to the peptidase M41 family


This is Heat shock protein homolog pss1 protein, from Fission yeast, contains 720 amino acids, is soluble, locates in Cytoplasm.

Required for normal growth at various temperatures

Belongs to the heat shock protein 70 family


This is Aspartic protease protein, from Yeast, contains 405 amino acids, is soluble, locates in Extracellular.

Possesses acidic protease activity, Hydrolyzes casein and azoalbumin in vitro


This is Pescadillo homolog protein, from Fission yeast, contains 607 amino acids, is soluble, locates in Nucleus.

Component of the NOP7 complex, which is required for maturation of the 25S and 5,8S ribosomal RNAs and formation of the 60S ribosome


This is Transcription factor tau subunit sfc6 protein, from Fission yeast, contains 582 amino acids, locates in Nucleus.

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements, Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function, Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes, Cooperates with sfc3 in DNA binding, Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization


This is Septation initiation protein sid4 protein, from Fission yeast, contains 660 amino acids, is soluble, locates in Cytoplasm.

Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis, May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach


This is Zinc finger protein 354A protein, from Human, contains 605 amino acids, has 13 C2H2-type Zinc finger, locates in Nucleus.

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Catalase-2 protein, from Caenorhabditis elegans, contains 497 amino acids, is soluble, locates in Cytoplasm.

Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable) (PubMed:25243607, PubMed:28456303), For instance plays a role in defending against oxidative damage induced by excessive copper stress (PubMed:25243607), Not required for maintaining normal lifespan (PubMed:14996832)


This is Flotillin-1 protein, from Fruit fly, contains 426 amino acids, is membrane-bound, locates in Cell membrane.

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles

Belongs to the band 7/mec-2 family, Flotillin subfamily


This is Katanin p80 WD40 repeat-containing subunit B1 protein, from Purple sea urchin, contains 690 amino acids, is soluble, locates in Cytoplasm.

Participates in a complex which severs microtubules in an ATP-dependent manner, May act to target the enzymatic subunit of this complex to sites of action such as the centrosome, Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation


This is Thioredoxin O1, mitochondrial protein, from Mouse-ear cress, contains 194 amino acids, is soluble, locates in Mitochondrion.

Thiol-disulfide oxidoreductase that may participate in various redox reactions, Possesses insulin disulfide bonds reducing activity, Reduced by thioredoxin reductases NTRA and NTRB

Belongs to the thioredoxin family, Plant O-type subfamily


This is Acyl-coenzyme A oxidase, peroxisomal protein, from Pumpkin, contains 690 amino acids, locates in Peroxisome.

Catalyzes the desaturation of long-chain acyl-CoAs to 2-trans-enoyl-CoAs


This is Aquaporin TIP1-1 protein, from Maize, contains 250 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Water channel required to facilitate the transport of water across cell membrane, May support the rapid influx of water into vacuoles during cell expansion, permit osmotic equilibration between the cytosol and the vacuolar content and rapid transcellular water flow through living cells, Its function is impaired by Hg(2+)

Belongs to the MIP/aquaporin (TC 1,A,8) family, TIP (TC 1,A,8,10) subfamily


This is Peptidyl-prolyl cis-trans isomerase CYP28, chloroplastic protein, from Mouse-ear cress, contains 281 amino acids, locates in Plastid.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)

Belongs to the cyclophilin-type PPIase family


This is Zinc finger protein ZAT3 protein, from Mouse-ear cress, contains 284 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Mediates the regulation of male germ cell division by DUO1


This is Cyclase-associated protein 1 protein, from Mouse-ear cress, contains 476 amino acids, is soluble, locates in Cytoplasm.

Actin monomer binding protein that accelerates the exchange of ADP for ATP, Regulates the pool of unpolymerized ATP-actin, Key intermediate between actin-depolymerizing factor (ADF)-mediated disassembly and the profilin-based nucleation and elongation machinery


This is LIM domain-binding protein 1-A protein, from Zebrafish, contains 374 amino acids, locates in Nucleus.

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors


This is Beta-mannosidase A protein, from Aspergillus aculeatus, contains 937 amino acids, is soluble, locates in Extracellular.

Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length, Involved in the degradation of polymeric mannan and galactomannan, Releases the terminal mannose residue from mannotriose and is somewaht less active on other mannooligosaccharides

Belongs to the glycosyl hydrolase 2 family, Beta-mannosidase A subfamily


This is FK506-binding protein 39 kDa protein, from Fission yeast, contains 361 amino acids, locates in Nucleus.

PPIase that acts as a histone chaperone (PubMed:14981505), Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail, Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity)

Belongs to the FKBP-type PPIase family, FKBP3/4 subfamily


This is SWI/SNF chromatin-remodeling complex subunit sol1 protein, from Fission yeast, contains 865 amino acids, locates in Nucleus.

Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes, It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors


This is Maintenance of mitochondrial morphology protein 1 protein, from Fission yeast, contains 313 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria, Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria, The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex, The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex, Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids


This is Ribosome biogenesis protein erb1 protein, from Fission yeast, contains 740 amino acids, is soluble, locates in Nucleus.

Component of the NOP7 complex, which is required for maturation of the 25S and 5,8S ribosomal RNAs and formation of the 60S ribosome

Belongs to the WD repeat BOP1/ERB1 family


This is ERO1-like protein 1 protein, from Fission yeast, contains 467 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds, Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange, Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent, Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins, Its reoxidation probably involves electron transfer to molecular oxygen via FAD, Acts independently of glutathione, May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress


This is Transcription factor cbf12 protein, from Fission yeast, contains 963 amino acids, locates in Nucleus.

Transcription factor which function may be to trigger the increase of adhesion at stationary phase, possibly by counteracting or replacing cbf11 at the respective promoters, May also play a cbf11-antagonistic role in the regulation of a number of other important processes such as extracellular material production, colony morphogenesis, ploidy maintenance, or meiosis