This is ETS homologous factor protein, from Human, contains 300 amino acids, locates in Nucleus.

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation, May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades, Binds to DNA sequences containing the consensus nucleotide core sequence GGAA, Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter, May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene


This is G-protein coupled receptor family C group 5 member D protein, from Human, contains 345 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the G-protein coupled receptor 3 family


This is Glycolipid transfer protein protein, from Human, contains 209 amino acids, is soluble, locates in Cytoplasm.

Accelerates the intermembrane transfer of various glycolipids, Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids, May be involved in the intracellular translocation of glucosylceramides


This is Interleukin-36 beta protein, from Human, contains 164 amino acids, is soluble, locates in Extracellular.

Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response, Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP, Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases, Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation, In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6


This is Grainyhead-like protein 1 homolog protein, from Human, contains 618 amino acids, locates in Nucleus.

May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed

Belongs to the grh/CP2 family, Grainyhead subfamily


This is Diphosphoinositol polyphosphate phosphohydrolase 2 protein, from Human, contains 180 amino acids, is soluble, locates in Cytoplasm.

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568, PubMed:12370170), Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (PubMed:12370170), Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170), Does not play a role in U8 snoRNA decapping activity (By similarity), Binds U8 snoRNA (By similarity)

Belongs to the Nudix hydrolase family, DIPP subfamily


This is Adenosine deaminase 2 protein, from Human, contains 511 amino acids, is soluble, locates in Extracellular.

Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses, Requires elevated adenosine levels for optimal enzyme activity, Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity

Belongs to the metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family, ADGF subfamily


This is Zinc finger protein 224 protein, from Human, contains 707 amino acids, has 17 C2H2-type Zinc finger, has 1 C2H2-type 14; degenerate Zinc finger, locates in Nucleus.

C2H2-type 14; degenerate

May be involved in transcriptional regulation as a transcriptional repressor, The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Ribosome biogenesis protein NOP53 protein, from Human, contains 478 amino acids, locates in Nucleus.

Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868), In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611), Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214), DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214), It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597), Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway (PubMed:15355975, PubMed:16971513, PubMed:27729611), May also inhibit cell proliferation and increase apoptosis through its interaction with NF2 (PubMed:21167305), May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation (PubMed:25818168), Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex (PubMed:25956029), May also regulate cellular aerobic respiration (PubMed:24556985), In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of RIGI (PubMed:27824081)


This is Protein cornichon homolog 4 protein, from Human, contains 139 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750)


This is NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 protein, from Human, contains 175 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723), May be involved in cell proliferation and survival of hormone-dependent tumor cells, May be a regulator of breast tumor cell invasion


This is Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 protein, from Human, contains 362 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle, This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle, This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation, Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators, May be involved in Rac1-signaling pathways leading to the modulation of gene expression, Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571)

Belongs to the very long-chain fatty acids dehydratase HACD family


This is GSK3B-interacting protein protein, from Human, contains 139 amino acids, is soluble, locates in Cytoplasm.

A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698), The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698), Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809), During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702)


This is ORM1-like protein 1 protein, from Human, contains 153 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Negative regulator of sphingolipid synthesis


This is Mitochondrial import receptor subunit TOM7 homolog protein, from Human, contains 55 amino acids, is membrane-bound, locates in Mitochondrion.

Required for assembly and stability of the TOM complex, Positive regulator of PRKN translocation to damaged mitochondria, Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria


This is CXXC-type zinc finger protein 1 protein, from Human, contains 656 amino acids, has 1 PHD-type Zinc finger, has 1 CXXC-type Zinc finger, locates in Nucleus.

PHD-type

CXXC-type

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG


This is Septin-10 protein, from Human, contains 454 amino acids, is soluble, locates in Cytoplasm.

Filament-forming cytoskeletal GTPase, May play a role in cytokinesis (Potential)

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family


This is Spermatogenesis-associated protein 7 protein, from Human, contains 599 amino acids, is soluble, locates in Cytoplasm.

Involved in the maintenance of both rod and cone photoreceptor cells (By similarity), It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC (By similarity), Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration (By similarity)


This is Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 protein, from Human, contains 774 amino acids, is membrane-bound, locates in Cell membrane.

Hyperpolarization-activated potassium channel, May also facilitate the permeation of sodium ions

Belongs to the potassium channel HCN family


This is Centrosomal protein of 72 kDa protein, from Human, contains 647 amino acids, is soluble, locates in Cytoplasm.

Involved in the recruitment of key centrosomal proteins to the centrosome, Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids, Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135), Involved in centriole duplication, Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806)


This is Stromal interaction molecule 2 protein, from Human, contains 746 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores, Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx, Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations, Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3, May inhibit STIM1-mediated Ca(2+) influx


This is BRCA2 and CDKN1A-interacting protein protein, from Human, contains 314 amino acids, locates in Nucleus.

During interphase, required for microtubule organizing and anchoring activities, During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342), Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342), May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A, May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2, May not be involved in non-homologous end joining (NHEJ)


This is C5a anaphylatoxin chemotactic receptor 2 protein, from Human, contains 337 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively, Couples weakly to G(i)-mediated signaling pathways

Belongs to the G-protein coupled receptor 1 family


This is ABI gene family member 3 protein, from Human, contains 366 amino acids, is soluble, locates in Cytoplasm.

May inhibit tumor metastasis (By similarity), In vitro, reduces cell motility


This is Kelch-like protein 42 protein, from Human, contains 505 amino acids, is soluble, locates in Cytoplasm.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis, The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1, Involved in microtubule dynamics throughout mitosis


This is LRP2-binding protein protein, from Human, contains 347 amino acids, is soluble, locates in Cytoplasm.

May act as an adapter that regulates LRP2 function


This is Homologous-pairing protein 2 homolog protein, from Human, contains 217 amino acids, locates in Nucleus.

Plays an important role in meiotic recombination, Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis, The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA, This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA, This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing, May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3, Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors


This is Dynein intermediate light chain dil1 protein, from Fission yeast, contains 360 amino acids, is soluble, locates in Cytoplasm.

Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity), Promotes oscillatory nuclear movement and efficient pairing of homologous centromeres during meiotic prophase

Belongs to the dynein light intermediate chain DYN3 family


This is Serine/threonine-protein kinase ppk15 protein, from Fission yeast, contains 534 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Transcription factor IIIB 60 kDa subunit protein, from Fission yeast, contains 492 amino acids, has 1 TFIIB-type Zinc finger, locates in Nucleus.

TFIIB-type

General activator of RNA polymerase III transcription


This is Aconitase-ribosomal protein bL21m fusion protein protein, from Fission yeast, contains 918 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

In the C-terminal section; belongs to the bacterial ribosomal protein bL21 family


This is Copper amine oxidase 1 protein, from Fission yeast, contains 712 amino acids, is soluble, locates in Cytoplasm.

Copper amine oxidase involved in the metabolism of xenobiotic and biogenic amines, Capable of catalyzing the oxidative deamination of primary amines such as ethylamine as alternate sources of nitrogen to support growth

Belongs to the copper/topaquinone oxidase family


This is Calcium/calmodulin-dependent protein kinase type I protein, from Fission yeast, contains 335 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily


This is Transcriptional adapter 2 protein, from Fission yeast, contains 437 amino acids, has 1 ZZ-type Zinc finger, locates in Nucleus.

ZZ-type

Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA, SAGA is involved in RNA polymerase II-dependent transcriptional regulation, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8), SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation, SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3, ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B (By similarity), Required for full activation of chromatin alteration and meiotic recombination at meiotic recombination hot spot ade6-M26, Also required for the regulation of transcription and chromatin structure around ade6-M26 in response to osmotic stress, Needed for hyperacetylation of histone H3 around ade6-M26


This is Septin ring organizing protein mid2 protein, from Fission yeast, contains 706 amino acids, is soluble, locates in Cytoplasm.

Responsible for the proper stability and function of septins during cytokinesis, Required for the correct formation of the medial septin ring structure in mitosis and for the proper localization of endo-glucanases agn1 and eng1, which are needed for efficient cell separation, May act as a landmark for the localization of hydrolytic proteins to the medial region


This is Triosephosphate isomerase protein, from Yeast, contains 248 amino acids, is soluble, locates in Cytoplasm.

Belongs to the triosephosphate isomerase family


This is Ovocleidin-17 protein, from Chicken, contains 142 amino acids, is soluble, locates in Extracellular.

May form proteinaceous networks during the construction of the eggshell which then may control the deposition of the mineral phase


This is Forkhead box protein D1 protein, from African clawed frog, contains 345 amino acids, locates in Nucleus.

Transcriptional repressor that down-regulates bmp4 signaling in both mesoderm and ectoderm, Regulates mesoderm patterning by repressing ventral mesoderm genes and promoting the expression of dorsolateral genes, Can also neuralize ectodermal cells directly, Inhibits neural crest migration, The transcription factors foxd1 and foxg1 mutually repress each other to pattern the forebrain


This is Transforming acidic coiled-coil-containing protein 3 protein, from African clawed frog, contains 931 amino acids, is soluble, locates in Cytoplasm.

Maternal RNA in oocytes remains in a dormant state as masking outcompetes eif4g to bind eif4e, thereby preventing translation, During oocyte maturation this complex dissolves and eif4g binds eif4e to allow translation of maternal RNAs (PubMed:10635326), Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome (By similarity), Involved in microtubule assembly during M-phase, Involved in spindle pole assembly by recruiting and regulating ckap5 at the spindle pole leading to microtubule elongation (PubMed:16172207, PubMed:25262927)


This is Toll-like receptor 4 protein, from Mouse, contains 835 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Required for the virulence of fungus C,neoformans var, grubii serotype A (strain KN99) CPL1 (PubMed:35896747), Independently of Ly96/Md2, activated by CPL1 which results in a type 2 inflammation response characterized by Arg1/arginase-1 induction in interstitial macrophages (PubMed:35896747)

Belongs to the Toll-like receptor family


This is Semaphorin-7A protein, from Mouse, contains 664 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses, Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3, Promotes production of pro-inflammatory cytokines by monocytes and macrophages, Plays an important role in modulating inflammation and T-cell-mediated immune responses, Promotes axon growth in the embryonic olfactory bulb, Promotes attachment, spreading and dendrite outgrowth in melanocytes


This is Hairy/enhancer-of-split related with YRPW motif protein 2 protein, from Mouse, contains 339 amino acids, locates in Nucleus.

Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development, Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development, May be required in conjunction with HEY1 to specify arterial cell fate or identity, Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification, Binds preferentially to the canonical E box sequence 5'-CACGTG-3', Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3


This is Keratin, type I cytoskeletal 17 protein, from Mouse, contains 433 amino acids, is soluble, locates in Cytoplasm.

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408), Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408), Modulates the function of TNF-alpha in the specific context of hair cycling, Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422), Involved in tissue repair, May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells', Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598), May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation

Belongs to the intermediate filament family


This is Myeloid leukemia factor 1 protein, from Mouse, contains 267 amino acids, locates in Cytoplasm.

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation, Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels, Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest, Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus


This is Rho guanine nucleotide exchange factor 9 protein, from Rat, contains 493 amino acids, is soluble, locates in Cytoplasm.

Acts as guanine nucleotide exchange factor (GEF) for CDC42, Promotes formation of GPHN clusters


This is Ammonium transporter Rh type C protein, from Mouse, contains 498 amino acids, is membrane-bound, locates in Cell membrane.

Ammonium transporter involved in the maintenance of acid-base homeostasis, Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism, Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+), As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:16131648) (By similarity), May act as a CO2 channel providing for renal acid secretion (By similarity)

Belongs to the ammonium transporter (TC 2,A,49) family, Rh subfamily


This is Epidermal growth factor-like protein 7 protein, from Mouse, contains 275 amino acids, is soluble, locates in Extracellular.

Regulates vascular tubulogenesis in vivo, Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis


This is FMR1-interacting protein NUFIP1 protein, from Mouse, contains 484 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.


This is Photoreceptor-specific nuclear receptor protein, from Mouse, contains 395 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Orphan nuclear receptor of retinal photoreceptor cells, Transcriptional factor that is an activator of rod development and repressor of cone development, Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit, Enhances rhodopsin expression, Represses M- and S-cone opsin expression

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Melanopsin protein, from Mouse, contains 521 amino acids, is membrane-bound, locates in Cell membrane.

Photoreceptor that binds cis-retinaldehydes (PubMed:19793992), Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light (PubMed:12808468), May be involved in the optokinetic visual tracking response (PubMed:26392540), May be involved in the regulation of retinal hyaloid vessel growth and regression (PubMed:30936473)

Belongs to the G-protein coupled receptor 1 family, Opsin subfamily


This is Forkhead box protein E3 protein, from Mouse, contains 288 amino acids, locates in Nucleus.

Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:10652278, PubMed:10890982), During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (PubMed:16199865), Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (PubMed:10652278), Is required for morphogenesis and differentiation of the anterior segment of the eye (PubMed:17064680), Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (By similarity)


This is Zinc finger protein SNAI3 protein, from Mouse, contains 287 amino acids, has 4 C2H2-type Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger, locates in Nucleus.

C2H2-type 5; degenerate

Seems to inhibit myoblast differentiation, Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes, Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'

Belongs to the snail C2H2-type zinc-finger protein family


This is DnaJ homolog subfamily B member 9 protein, from Mouse, contains 222 amino acids, is soluble, locates in Endoplasmic reticulum.

Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity), J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:11836248), In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity), Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:22267725), Required for survival of B-cell progenitors and normal antibody production (PubMed:25222125)


This is Centromere protein H protein, from Mouse, contains 241 amino acids, locates in Nucleus.

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation, The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres, Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity)


This is 5-azacytidine-induced protein 2 protein, from Mouse, contains 405 amino acids, is soluble, locates in Cytoplasm.

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity, Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization, Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1, Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B, Participates in IFNB promoter activation via TICAM1


This is Protein AATF protein, from Rat, contains 523 amino acids, locates in Nucleus.

May function as a general inhibitor of the histone deacetylase HDAC1, Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression, Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression, May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK, Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity), May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK, Can act cooperatively with TSG101 to stimulate AR mediated transcription activation


This is Zinc finger and BTB domain-containing protein 7A protein, from Rat, contains 569 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, locates in Nucleus.

C2H2-type 4; atypical

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (By similarity) (PubMed:10477728), Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity) (PubMed:10477728), Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms, That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity), Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity), Also directly interacts with transcription factors like SP1 to prevent their binding to DNA, Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation, Involved in the switch between fetal and adult globin expression during erythroid cells maturation, Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (By similarity), Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene, Efficiently abrogates E2F1-dependent CDKN2A transactivation, Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity), Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis, Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity), Plays a key role in the differentiation of lymphoid progenitors into B and T lineages, Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity), Also regulates osteoclast differentiation (PubMed:10477728), May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ, Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity), May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity)


This is Doublesex- and mab-3-related transcription factor 1 protein, from Mouse, contains 374 amino acids, locates in Nucleus.

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation, Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm, Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1, Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes, May act as a tumor suppressor, May also play a minor role in oogenesis


This is Neuronal PAS domain-containing protein 3 protein, from Mouse, contains 925 amino acids, locates in Nucleus.

May play a broad role in neurogenesis, May control regulatory pathways relevant to schizophrenia and to psychotic illness


This is Septin-9 protein, from Rat, contains 564 amino acids, is soluble, locates in Cytoplasm.

Filament-forming cytoskeletal GTPase (By similarity), May play a role in cytokinesis (Potential)


This is C-type lectin domain family 5 member A protein, from Mouse, contains 190 amino acids, is membrane-bound, locates in Cell membrane.

Functions as a positive regulator of osteoclastogenesis (PubMed:19251634), Cell surface receptor that signals via TYROBP (PubMed:10449773), Regulates inflammatory responses (PubMed:20212065)


This is Pendrin protein, from Mouse, contains 780 amino acids, is membrane-bound, locates in Cell membrane.

Sodium-independent transporter of chloride and iodide (By similarity), Mediates electroneutral iodide-chloride, iodide-bicarbonate and chloride-bicarbonate exchange with 1:1 stoichiometry (PubMed:11274445, PubMed:18565999), Mediates elctroneutral chloride-formate exchange (By similarity)

Belongs to the SLC26A/SulP transporter (TC 2,A,53) family


This is Metastasis-associated protein MTA2 protein, from Mouse, contains 668 amino acids, has 1 GATA-type; atypical Zinc finger, locates in Nucleus.

GATA-type; atypical

May function as a transcriptional coregulator (By similarity), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity)


This is Forkhead box protein O1 protein, from Mouse, contains 652 amino acids, locates in Cytoplasm.

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:12219087, PubMed:12754525, PubMed:15184386, PubMed:15220471, PubMed:16917544, PubMed:17090532, PubMed:17627282, PubMed:17681146, PubMed:20519497, PubMed:20668652, PubMed:21196578, PubMed:21335550, PubMed:21471200, PubMed:22298775, PubMed:22417654, PubMed:22510882, PubMed:27457971, PubMed:34914893), Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:17090532, PubMed:21335550), Activity suppressed by insulin (PubMed:12754525, PubMed:17627282), Main regulator of redox balance and osteoblast numbers and controls bone mass (PubMed:21471200, PubMed:22298775), Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (PubMed:21471200, PubMed:22298775), Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177), Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (PubMed:22298775), Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (PubMed:21471200), Acts as an inhibitor of glucose sensing in pancreatic beta cells by acting as a transcription repressor and suppressing expression of PDX1 (PubMed:12219087, PubMed:27457971), In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1 (PubMed:12754525, PubMed:25009184), Also promotes gluconeogenesis by directly promoting expression of PPARGC1A and G6PC1 (By similarity), Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (By similarity), Promotes neural cell death (By similarity), Mediates insulin action on adipose tissue (By similarity), Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity), Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (PubMed:21196578), Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (By similarity), Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity), Regulates endothelial cell (EC) viability and apoptosis in a PPIA/CYPA-dependent manner via transcription of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity)


This is Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 protein, from Mouse, contains 862 amino acids, is soluble, locates in Extracellular.

Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:17208043, PubMed:28414242, PubMed:27780639), Major substrate is lysophosphatidylcholine (PubMed:17208043, PubMed:27780639), Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility, Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:18175805), Involved in several motility-related processes such as angiogenesis and neurite outgrowth, Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation, Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein, May have a role in induction of parturition (By similarity), Possible involvement in cell proliferation and adipose tissue development (Probable), Tumor cell motility-stimulating factor, Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity), Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity)

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family


This is Carbohydrate sulfotransferase 4 protein, from Mouse, contains 388 amino acids, is membrane-bound, locates in Golgi apparatus.

Sulfotransferase involved in SELL/L-selectin ligand biosynthesis pathway, Catalyzes the transfer of the sulfate group from 3'-phospho-5'-adenylyl sulfate (PAPS) onto the hydroxyl group at C-6 position of the non-reducing N-acetylglucosamine (GlcNAc) residue within O-linked mucin-type glycans (PubMed:10435581, PubMed:16227985, PubMed:15319280, PubMed:16227986, PubMed:14597732, PubMed:15111310), Contributes to generate sialyl 6-sulfo Lewis X determinant (also known as MECA-79 epitope) for SELL recognition, a prerequisite for continuous lymphocyte homing into peripheral lymph nodes and antigen immune surveillance, Transfers the sulfate group primarily on core 2 GlcNAcbeta1-6(Galbeta1-3)GalNAcalphaSer/Thr and extended core 1 GlcNAcbeta1-3Galbeta1-3GalNAcalphaSer/Thr based O-linked glycans on CD34 and GLYCAM1 peripheral node addressins (PNAds) expressed on the lumenal side of high endothelial venules (HEVs) (PubMed:10435581, PubMed:16227985, PubMed:15319280, PubMed:16227986, PubMed:15111310, PubMed:14593101), The recognition of PNAds by SELL initiates a multistep process comprising tethering and rolling of blood lymphocytes on HEVs against the blood flow, followed by chemokine signaling, integrin-mediated lymphocyte adhesion onto endothelial cells and lymphocyte transendothelial migration, Modulates rolling velocity and differential T and B lymphocyte recruitment into peripheral lymph nodes, with a major role in B lymphocyte homing (PubMed:16227985, PubMed:15319280, PubMed:16227986, PubMed:14597732, PubMed:10435581), Might be redundant in sulfation of MADCAM1 and lymphocyte trafficking to mesenteric lymph nodes (PubMed:10435581, PubMed:11520459, PubMed:16227986), Can also sulfonate core 3 GlcNAcbeta1-3GalNAc-R based glycans as well as GlcNAcbeta1-3Galbeta1-Glc, GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharides, which might be ectopically expressed during tumorigenesis (By similarity)

Belongs to the sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily


This is Collagen alpha-1(XIII) chain protein, from Mouse, contains 751 amino acids, is membrane-bound, locates in Cell membrane.

Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development, May participate in the linkage between muscle fiber and basement membrane, May play a role in endochondral ossification of bone and branching morphogenesis of lung, Binds heparin, At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625)


This is Cyclin-L1 protein, from Rat, contains 527 amino acids, is soluble, locates in Nucleus.

Involved in pre-mRNA splicing (PubMed:11683997), Functions in association with cyclin-dependent kinases (CDKs), May play a role in the regulation of RNA polymerase II (pol II), Inhibited by the CDK-specific inhibitor CDKN1A/p21 (By similarity)

Belongs to the cyclin family, Cyclin L subfamily


This is B9 domain-containing protein 1 protein, from Mouse, contains 204 amino acids, is soluble, locates in Cytoplasm.

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes, Required for ciliogenesis and sonic hedgehog/SHH signaling


This is Protein BEX1 protein, from Mouse, contains 128 amino acids, locates in Cytoplasm.

Signaling adapter molecule involved in p75NTR/NGFR signaling, Plays a role in cell cycle progression and neuronal differentiation, Inhibits neuronal differentiation in response to nerve growth factor (NGF), May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity)


This is KH domain-containing, RNA-binding, signal transduction-associated protein 3 protein, from Mouse, contains 346 amino acids, locates in Nucleus.

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion, Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro (PubMed:19457263), Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides (By similarity), Binds poly(A), RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:15471878), Involved in splice site selection of vascular endothelial growth factor (By similarity), In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity), Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members, High concentrations in forebrain structures block splicing inclusion of NRXN1-3 AS4 exons while low concentrations favor their inclusion, Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity and is linked to behavioral aspects (PubMed:22196734, PubMed:23637638, PubMed:24469635, PubMed:27174676), Regulates expression of KHDRBS2/SLIM-1 in defined neuron populations in the hippocampus by modifying its alternative splicing resulting in a transcript predicted to undergo nonsense-mediated decay (PubMed:25505328), Can bind FABP9 mRNA (PubMed:19916944), May play a role as a negative regulator of cell growth, Inhibits cell proliferation


This is Splicing factor U2af small subunit A protein, from Mouse-ear cress, contains 296 amino acids, has 2 C3H1-type Zinc finger, locates in Nucleus.

Necessary for the splicing of pre-mRNA (By similarity), Probably active at the 3' splice sites

Belongs to the splicing factor SR family


This is Serine/threonine-protein kinase STN7, chloroplastic protein, from Mouse-ear cress, contains 562 amino acids, is membrane-bound, locates in Plastid.

Serine/threonine protein kinase required for state transition by phosphorylating light-harvesting complex II outer antennae (LCHII), State transition plays a central role in response to environmental changes and allows to adjust to changing light conditions via the redistribution of light excitation energy between photosystem II (PSII) and photosystem I (PSI), Phosphorylates the minor light harvesting protein LHCB4,2/CP29 and is involved in the light-dependent phosphorylation of TSP9, Acts as a key component of the long-term response (LTR) signaling pathway, Mediates phosphorylation-dependent PTAC16 subcellular localization to regulate plastid gene expression (PubMed:22616989)


This is Protein OBERON 1 protein, from Mouse-ear cress, contains 566 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Probable transcription factor that acts together with OBE2 for the maintenance and/or establishment of both the shoot and root meristems, probably by controlling the expression of the meristem genes such as WUS, PLT1 and PLT2 and of genes required for auxin responses, Promotes cell meristematic activity via the WUSCHEL-CLAVATA pathway, Involved in the development of the basal pole and in auxin-mediated root and vascular development in the embryo, Confers sensitivity to turnip mosaic virus (TuMV) probably by promoting viral movement and multiplication via interaction with TuMV VPg


This is Probable E3 ubiquitin-protein ligase LOG2 protein, from Mouse-ear cress, contains 388 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Cell membrane.

RING-type; atypical

Acts as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates (in vitro), Required for GLUTAMINE DUMPER 1(GDU1)-induced amino acid secretion and for amino acid homeostasis, Ubiquitinates GDU1 (in vitro)

Belongs to the RING-type zinc finger family, LOG2 subfamily


This is AT-hook motif nuclear-localized protein 27 protein, from Mouse-ear cress, contains 311 amino acids, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (PubMed:17971039, PubMed:19517252), Negatively regulates plant innate immunity (PTI) to pathogens through the down-regulation of the PAMP-triggered FRK1 expression (PubMed:20738724), Acts redundantly with AHL18, AHL22 and AHL29 in the regulation of flowering and regulation of the hypocotyl elongation (PubMed:19517252), Acts as a chromatin remodeling factor that negatively regulates the leaf senescence (PubMed:17971039), Acts redundantly with AHL29/SOB3 to modulate hypocotyl growth inhibition in response to light (PubMed:18088311)


This is Digalactosyldiacylglycerol synthase 1, chloroplastic protein, from Mouse-ear cress, contains 808 amino acids, is membrane-bound, locates in Plastid.

Involved in the synthesis of diacylglycerol galactolipids that are specifically found in thylakoid membranes (PubMed:20181751, PubMed:10381884, PubMed:14600212), Specific for alpha-glycosidic linkages (PubMed:10381884, PubMed:14600212), Responsible for the final assembly of galactolipids in photosynthetic membranes, Digalactosyldiacylglycerol (DGDG) provides stability to the photosystem I (PSI) complex, especially to the PsaA, PsaB, PsaC, PsaL and PsaH subunits (PubMed:15961080, PubMed:16854937)

Belongs to the glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily


This is Glutamate--glyoxylate aminotransferase 2 protein, from Mouse-ear cress, contains 481 amino acids, locates in Peroxisome.

Catalyzes the Glu:glyoxylate aminotransferase (GGT), Ala:glyoxylate aminotransferase (AGT), Ala:2-oxoglutarate aminotransferase (AKT) and Glu:pyruvate aminotransferase (GPT) reactions in peroxisomes

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily


This is Polyribonucleotide nucleotidyltransferase 2, mitochondrial protein, from Mouse-ear cress, contains 991 amino acids, locates in Mitochondrion.

Involved in the 3'-end maturation of mitochondrial mRNAs, rRNAs and tRNAs, Functions as a poly(A) mRNA 3'-5' degrading phosphorylase and is required for the degradation of highly expressed transcripts of non-coding regions

Belongs to the polyribonucleotide nucleotidyltransferase family


This is Cell division cycle 20.2, cofactor of APC complex protein, from Mouse-ear cress, contains 447 amino acids, locates in Nucleus.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle

Belongs to the WD repeat CDC20/Fizzy family


This is Chlorophyll a-b binding protein 3, chloroplastic protein, from Mouse-ear cress, contains 265 amino acids, is membrane-bound, locates in Plastid.

The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated (PubMed:26562806), Modulates the rate of photosystem II (PSII) state transitions and influences PSII macrostructure (PubMed:19880802), Involved in PSII excitation energy transfer and charge separation during photosynthesis in thylakoids (PubMed:26562806)

Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family


This is L-tryptophan--pyruvate aminotransferase 1 protein, from Mouse-ear cress, contains 391 amino acids, is soluble, locates in Cytoplasm.

L-tryptophan aminotransferase involved in auxin (IAA) biosynthesis, Can convert L-tryptophan and pyruvate to indole-3-pyruvic acid (IPA) and alanine, Catalyzes the first step in IPA branch of the auxin biosynthetic pathway, Required for auxin production to initiate multiple change in growth in response to environmental and developmental cues, It is also active with phenylalanine, tyrosine, leucine, alanine, methionine and glutamine, Both TAA1 and TAR2 are required for maintaining proper auxin levels in roots, while TAA1, TAR1 and TAR2 are required for proper embryo patterning, Involved in the maintenance of the root stem cell niches and required for shade avoidance


This is Photosystem I reaction center subunit V, chloroplastic protein, from Mouse-ear cress, contains 160 amino acids, is membrane-bound, locates in Plastid.


This is Ninja-family protein AFP4 protein, from Mouse-ear cress, contains 319 amino acids, locates in Nucleus.

Acts as a negative regulator of abscisic acid (ABA) and salinity responses


This is Auxin efflux carrier component 3 protein, from Mouse-ear cress, contains 640 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a component of the auxin efflux carrier, Seems to be involved in the lateral auxin transport system and mediates tropic growth, Coordinated polar localization of PIN3 is directly regulated by the vesicle trafficking process

Belongs to the auxin efflux carrier (TC 2,A,69,1) family


This is Non-specific phospholipase C5 protein, from Mouse-ear cress, contains 521 amino acids, is soluble, locates in Cytoplasm.

Non-specific phospholipase C (PLC) which assumes minor PLC activity during inorganic phosphate starvation, Can hydrolyze both phosphatidylcholine (PC) and phosphatidylethanolamine (PE), Required for normal accumulation of digalactosyldiacylglycerol (DGDG) during phosphate limitation and may contribute to the conversion of phospholipids to diacylglycerol, the substrate for galactolipid synthesis

Belongs to the bacterial phospholipase C family


This is Short-chain dehydrogenase/reductase SDRA protein, from Mouse-ear cress, contains 254 amino acids, locates in Peroxisome.

Involved with IBR3 and IBR10 in the peroxisomal beta-oxidation of indole-3-butyric acid (IBA) to form indole-3-acetic acid (IAA), a biologically active auxin, May be responsible for catalyzing the dehydrogenation step in the conversion of IBA (PubMed:20562230), May be involved in the peroxisomal activation of 2,4-dichlorophenoxybutyric acid (2,4-DB), a precursor of active auxins that inhibit root growth (PubMed:19043666)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Obg-like ATPase 1 protein, from Mouse-ear cress, contains 394 amino acids, is soluble, locates in Cytoplasm.

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency, Has lower affinity for GTP (Potential), Exhibits GTPase activity (By similarity), Confers sensitivity to salinity stress by suppressing the anti-oxidation enzymatic activities and increasing lipid peroxidation thus leading to the accumulation of reactive oxygen species (ROS) (PubMed:23550829), Acts as negative regulator of disease resistance against bacterial pathogen (PubMed:26912459)

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, YchF/OLA1 subfamily


This is UDP-arabinose 4-epimerase 1 protein, from Mouse-ear cress, contains 419 amino acids, is membrane-bound, locates in Golgi apparatus.

Acts as a UDP-D-xylose 4-epimerase but lacks both UDP-D-glucose and UDP-D-glucuronic acid 4-epimerase activities in vitro

Belongs to the NAD(P)-dependent epimerase/dehydratase family


This is Metal transporter Nramp1 protein, from Mouse-ear cress, contains 532 amino acids, is membrane-bound, locates in Cell membrane.

High affinity manganese (Mn) transporter involved in Mn acquisition from the soil, Required for Mn uptake into the root in conditions of low Mn availability, Can transport iron (Fe), cadmium (Cd) and cobalt (Co)


This is Deoxyribodipyrimidine photo-lyase protein, from Mouse-ear cress, contains 496 amino acids, locates in Nucleus.

Involved in repair of UV radiation-induced DNA damage, Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutylpyrimidine dimers (CPDs), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation, Required for plant survival in the presence of UV-B light, Not involved in the repair of (6-4) photoproducts

Belongs to the DNA photolyase class-2 family


This is Protein WUSCHEL protein, from Mouse-ear cress, contains 292 amino acids, locates in Nucleus.

Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes, Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM), May induce shoot stem cells activity in order to maintain the stem cell identity, Involved in the developmental root meristem, In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway, Also required to sustain organogenesis in the floral meristem by contributing to the expression of its own repressor, the AGAMOUS (AG) gene at the end of flower development, Binds directly to the 5'-TTAAT[GC][GC]-3' DNA sequence in the regulatory sequence of AG and activates its expression directly, Regulates one important step in ovule development to induce integument formation from the underlying chalazal domain, Participates in the promotion of vegetative to embryonic transition, Required to repress LEC1 expression


This is Acetylglutamate kinase, chloroplastic protein, from Mouse-ear cress, contains 347 amino acids, is soluble, locates in Plastid.

Involved in the arginine biosynthetic pathway via the intermediate compound ornithine

Belongs to the acetylglutamate kinase family, ArgB subfamily


This is Transcription factor MYB30 protein, from Mouse-ear cress, contains 323 amino acids, locates in Nucleus.

Transcription factor that binds specifically to the DNA sequence 5'-AACAAAC-3' (PubMed:19170933), Acts as a positive regulator of hypersensitive cell death (PubMed:10571865, PubMed:12119395), Acts as a positive regulator of salicylic acid synthesis (PubMed:16730712), Regulates very-long-chain fatty acid biosynthesis (PubMed:18326828), Acts cooperatively with BZR2 to promote expression of a subset of brassinosteroids target genes (PubMed:19170933), Transcriptional activity and hypersensitive response control negatively regulated by PLA2-ALPHA (PubMed:20696912), Involved in the regulation of abscisic acid (ABA) signaling (PubMed:22814374), Increased levels of MYB30 can accelerate flowering both in long and short days through the regulation of FT (PubMed:24587042)


This is Receptor-like protein kinase FERONIA protein, from Mouse-ear cress, contains 895 amino acids, is membrane-bound, locates in Cell membrane.

Receptor-like protein kinase that mediates the female control of male gamete delivery during fertilization, including growth cessation of compatible pollen tubes ensuring a reproductive isolation barriers, by regulating MLO7 subcellular polarization upon pollen tube perception in the female gametophyte synergids, Required for cell elongation during vegetative growth, mostly in a brassinosteroids- (BR-) independent manner, Acts as an upstream regulator for the Rac/Rop-signaling pathway that controls ROS-mediated root hair development, Seems to regulate a cross-talk between brassinosteroids and ethylene signaling pathways during hypocotyl elongation, Negative regulator of brassinosteroid response in light-grown hypocotyls, but required for brassinosteroid response in etiolated seedlings, Mediates sensitivity to powdery mildew (e,g, Golovinomyces orontii), Positive regulator of auxin-promoted growth that represses the abscisic acid (ABA) signaling via the activation of ABI2 phosphatase, Required for RALF1-mediated extracellular alkalinization in a signaling pathway preventing cell expansion

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Protein SHI RELATED SEQUENCE 1 protein, from Mouse-ear cress, contains 370 amino acids, locates in Nucleus.

Transcription activator that binds DNA on 5'-ACTCTAC-3' and promotes auxin homeostasis-regulating gene expression (e,g, YUC genes), as well as genes affecting stamen development, cell expansion and timing of flowering, Synergistically with other SHI-related proteins, regulates gynoecium, stamen and leaf development in a dose-dependent manner, controlling apical-basal patterning, Promotes style and stigma formation, and influences vascular development during gynoecium development, May also have a role in the formation and/or maintenance of the shoot apical meristem (SAM)


This is V-type proton ATPase subunit C protein, from Mouse-ear cress, contains 375 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Subunit of the peripheral V1 complex of vacuolar ATPase, Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity, V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells

Belongs to the V-ATPase C subunit family


This is Protein RESTRICTED TEV MOVEMENT 1 protein, from Mouse-ear cress, contains 174 amino acids, is soluble, locates in Cytoplasm.

Required for the restriction of long-distance movement of the pathogenic tobacco etch virus (TEV) without causing a hypersensitive response or inducing systemic acquired resistance


This is Homeobox-leucine zipper protein REVOLUTA protein, from Mouse-ear cress, contains 842 amino acids, locates in Nucleus.

Probable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems, Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation, May be involved in the determination of vascular patterning and organ polarity (PubMed:10559440, PubMed:11169198, PubMed:11402186, PubMed:15111711, PubMed:15598805, PubMed:7555701), Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4 (PubMed:22781836), Required to regulate adaxial-abaxial polarity and leaf axial patterning (PubMed:20807212)

Belongs to the HD-ZIP homeobox family, Class III subfamily


This is Beta-D-glucopyranosyl abscisate beta-glucosidase protein, from Mouse-ear cress, contains 528 amino acids, is soluble, locates in Endoplasmic reticulum.

Hydrolyzes abscisic acid glucose ester (ABA-GE) which represents the predominant form of conjugated ABA (biologically inactive), No activity with beta-D-glucopyranosyl zeatin, The hydrolysis of ABA-GE in the endoplasmic reticulum (ER) forms free ABA and contributes to increase its cellular levels under dehydration conditions, ABA-GE hydrolyzing activity is enhanced by dehydration stress-induced polymerization into higher molecular weight forms, The ABA produced by BGLU18 contributes to the initiation of intracellular signaling as well as the increase in the extracellular ABA level

Belongs to the glycosyl hydrolase 1 family


This is Serine/arginine-rich splicing factor SR45 protein, from Mouse-ear cress, contains 414 amino acids, is soluble, locates in Nucleus.

Involved in 5' and 3' splicing site selection of introns, and may bridge the 5' and 3' components of the spliceosome, Isoform 1 is required during flower petal development and isoform 2 is involved in root growth, Regulates negatively glucose and abscisic acid (ABA) signaling during early seedling development, Involved in the RNA-directed DNA methylation pathway (PubMed:22274613), Modulates KIN10 stability in response to sugars, probably through the splicing regulation of 5PTASE13, a protein implicated in the proteasomal degradation of KIN10 (PubMed:27436712)

Belongs to the splicing factor SR family, SR45 subfamily


This is Transcription factor WER protein, from Mouse-ear cress, contains 203 amino acids, locates in Nucleus.

Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1, Involved in epidermal cell fate specification in roots and hypocotyl, Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis, Regulates stomata spatial distribution in hypocotyls, Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC


This is Thioredoxin M4, chloroplastic protein, from Mouse-ear cress, contains 193 amino acids, is soluble, locates in Plastid.

Thiol-disulfide oxidoreductase involved in the redox regulation of enzyme of the oxidative pentose phosphate pathway, Under reducing conditions, inhibits the glucose-6-phosphate dehydrogenase

Belongs to the thioredoxin family, Plant M-type subfamily


This is Thioredoxin M3, chloroplastic protein, from Mouse-ear cress, contains 173 amino acids, is soluble, locates in Plastid.

Thiol-disulfide oxidoreductase required for maintaining symplastic permeability in the meristem, Involved in redox regulation of callose deposition, plasmodesmata cell-to-cell communication and meristem maintenance


This is Thioredoxin M2, chloroplastic protein, from Mouse-ear cress, contains 186 amino acids, is soluble, locates in Plastid.

Thiol-disulfide oxidoreductase that may participate in various redox reactions, May activate NADP-malate dehydrogenase


This is Protein IQ-DOMAIN 1 protein, from Mouse-ear cress, contains 454 amino acids, locates in Nucleus.

May be involved in cooperative interactions with calmodulins or calmodulin-like proteins, Modulates expression of glucosinolate pathway genes, May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (PubMed:15960618, PubMed:23204523), Recruits KLCR1 and calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (PubMed:23204523)


This is Protein DETOXIFICATION 43 protein, from Mouse-ear cress, contains 526 amino acids, is membrane-bound, locates in Cell membrane.

Citrate transporter responsible for loading citrate into xylem tissues, which helps facilitate iron transport to shoots (PubMed:12172022, PubMed:15310833, PubMed:17351051, PubMed:18826429), Mediates the citrate release in the apoplastic spaces during plant development allowing iron nutrition between symplastically disconnected tissues (PubMed:21742986)

Belongs to the multi antimicrobial extrusion (MATE) (TC 2,A,66,1) family


This is FHA domain-containing protein FHA2 protein, from Mouse-ear cress, contains 320 amino acids, locates in Nucleus.

May play a role in the control of plant organ development and specifically in the regulation of stamen development, Does not show transactivation activity in yeast


This is Glycerophosphodiester phosphodiesterase GDPD1, chloroplastic protein, from Mouse-ear cress, contains 361 amino acids, locates in Plastid.

Hydrolyzes glycerolphosphoglycerol, glycerophosphocholine and glycerophosphoethanolamine in vitro, May be involved in release of inorganic phosphate (Pi) from phospholipids during Pi starvation

Belongs to the glycerophosphoryl diester phosphodiesterase family


This is Photosynthetic NDH subunit of lumenal location 3, chloroplastic protein, from Mouse-ear cress, contains 220 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable), Required for both formation and activity of the chloroplast NAD(P)H dehydrogenase (NDH) complex (PubMed:20430763, PubMed:20460499)


This is Thioredoxin-like protein CDSP32, chloroplastic protein, from Mouse-ear cress, contains 302 amino acids, is soluble, locates in Plastid.

Probable thiol-disulfide oxidoreductase involved in resistance to oxidative stress, May participate in the reduction of alkyl hydroperoxides derived from oxidative stress by acting as a physiological electron donor to the BAS1 peroxiredoxin, May regenerate methionine sulfoxide reductase B1 (MSRB1) activity through sulfenic acid reduction


This is Methionine gamma-lyase protein, from Mouse-ear cress, contains 441 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the degradation of L-methionine to alpha-ketobutyrate, methanethiol and ammonia, Exhibits a high activity toward L-methionine, L-ethionine, L-homocysteine and seleno-L-methionine, but not L-cysteine, Involved in an alternative cysteine biosynthesis pathway to the reverse trans-sulfuration pathway (methionine->homocysteine->cystathionine->cysteine) in which methanethiol is an intermediate, Mediates also an alternative isoleucine biosynthesis pathway in which 2-ketobutyrate is an intermediate

Belongs to the trans-sulfuration enzymes family


This is Phosphatidylinositol:ceramide inositolphosphotransferase 2 protein, from Mouse-ear cress, contains 305 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the transfer of the phosphorylinositol group from phosphatidylinositol (PI) to phytoceramide, an essential step in sphingolipid biosynthesis (PubMed:19001565, PubMed:20309609), May play an important role in modulating plant programmed cell death (PCD) associated with defense (e,g, toward Golovinomyces cichoracearum) by promoting sphingolipid metabolism and thus regulating ceramide accumulation (PubMed:19001565)

Belongs to the sphingomyelin synthase family


This is Vesicle-associated protein 1-2 protein, from Mouse-ear cress, contains 239 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Vesicle-associated protein that binds the oxysterol-binding protein ORP3A and allows its targeting to the ER

Belongs to the VAMP-associated protein (VAP) (TC 9,B,17) family


This is Septin and tuftelin-interacting protein 1 homolog 1 protein, from Mouse-ear cress, contains 849 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events (By similarity), Involved in snRNPs recycling (PubMed:25568310), Required for efficient splicing of genes that act within the plant circadian clock (PubMed:23110899), Part of a transcription elongation checkpoint at alternative exons (PubMed:25568310), Required for correct expression and splicing of DOG1, a regulator of seed dormancy (PubMed:25568310), May induce transient transcriptional pausing of polymerase II at slices sites (PubMed:25568310)


This is UBP1-associated proteins 1A protein, from Mouse-ear cress, contains 343 amino acids, locates in Nucleus.

Acts as component of a complex regulating the turnover of mRNAs in the nucleus, Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs, May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucleus, However, unlike UBP1, UBA1A does not stimulate pre-mRNA splicing


This is Amidophosphoribosyltransferase 1, chloroplastic protein, from Mouse-ear cress, contains 566 amino acids, is soluble, locates in Plastid.

Catalyzes the first committed step of 'de novo' purine biosynthesis from glutamine, Involved in plastid biogenesis and cell division

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family


This is Elongation factor G, chloroplastic protein, from Mouse-ear cress, contains 783 amino acids, locates in Plastid.

Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids, Catalyzes the GTP-dependent ribosomal translocation step during translation elongation, During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively, Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome, Required for the eoplasts redifferentiation into chloroplasts after germination

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily


This is Aconitate hydratase 3, mitochondrial protein, from Mouse-ear cress, contains 990 amino acids, locates in Mitochondrion.

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, Contributes to oxidative stress tolerance (PubMed:17013749), Modulates cytosolic citrate metabolism during lipid mobilization, Required during seedling growth (PubMed:25061985)

Belongs to the aconitase/IPM isomerase family


This is Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase protein, from Mouse-ear cress, contains 475 amino acids, locates in Plastid.

Prokaryotic-type aspartate aminotransferase, Has also a prenate transaminase activity, Involved in the aromatic amino acids biosynthesis pathway via the arogenate route, Required for the transamination of prephenate into arogenate, Required for early development of the embryo

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is Heat shock protein 90-5, chloroplastic protein, from Mouse-ear cress, contains 780 amino acids, is soluble, locates in Plastid.

Molecular chaperone required for chloroplast biogenesis (PubMed:12943545, PubMed:25216779), Essential for chloroplast biogenesis and maintenance, and thus for embryogenesis (PubMed:23875936, PubMed:23382192), May be involved in the disassembly of VIPP1 for thylakoid membrane formation and/or maintenance (PubMed:23875936), Cooperates with TIC components and other molecular chaperones to drive transport of preproteins into chloroplasts and functions in the chloroplast stroma to facilitate membrane translocation during protein import into the organelle (PubMed:23382192)

Belongs to the heat shock protein 90 family


This is Casparian strip membrane protein 1 protein, from Mouse-ear cress, contains 206 amino acids, is membrane-bound, locates in Cell membrane.

Regulates membrane-cell wall junctions and localized cell wall deposition, Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion

Belongs to the Casparian strip membrane proteins (CASP) family


This is Phospholipase A1-Ialpha2, chloroplastic protein, from Mouse-ear cress, contains 484 amino acids, is soluble, locates in Plastid.

Acylhydrolase that catalyzes the hydrolysis of phosphatidylcholine at the sn-1 position, Has a strong galactolipase activity toward monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), Low triacylglycerol (TAG) lipase activity, Plays a role in plant growth and in leaf senescence

Belongs to the AB hydrolase superfamily, Lipase family


This is NAD-dependent malic enzyme 1, mitochondrial protein, from Mouse-ear cress, contains 623 amino acids, locates in Mitochondrion.

Involved in the regulation of sugars and amino acids metabolisms during the night period


This is Triphosphate tunnel metalloenzyme 3 protein, from Mouse-ear cress, contains 210 amino acids, locates in Nucleus.

Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked), Catalyzes the hydrolysis of inorganic triphosphate (PPPi), however it does not display significant activity towards long-chain polyphosphates, The existence of PPPi in living cells is still unclear, and PPPase activity might be the ancestral function of CYTH domain, It also has gamma-phosphatase activity on NTP substrates, but no adenylate cyclase or RNA triphosphatase activity


This is Ribonucleoside-diphosphate reductase large subunit protein, from Mouse-ear cress, contains 816 amino acids, is soluble, locates in Cytoplasm.

Provides the precursors necessary for DNA synthesis, Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides, R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide, Ribonucleotide reductase (RNR) complex function is essential for efficient organellar DNA degradation in pollen, Involved in chloroplast division

Belongs to the ribonucleoside diphosphate reductase large chain family


This is Vacuolar protein-sorting-associated protein 11 homolog protein, from Mouse-ear cress, contains 932 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Lysosome/Vacuole.

RING-type; atypical

Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment


This is mRNA-decapping enzyme-like protein protein, from Mouse-ear cress, contains 367 amino acids, is soluble, locates in Cytoplasm.

As a component of the decapping complex, involved in the degradation of mRNAs, Essential for postembryonic development


This is AT-hook motif nuclear-localized protein 16 protein, from Mouse-ear cress, contains 257 amino acids, locates in Nucleus.

Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (PubMed:25336567), Encodes a nuclear matrix protein that acts in the maintenance of genomic integrity by silencing TEs and repeat-containing genes through epigenetic machinery, Acts as a chromatin remodeling factor that modifies the architecture of FLC and FWA chromatin by modulating both H3 acetylation and methylation leading to the regulation of FLC and FWA expression (PubMed:23394836, PubMed:23836195), Negatively regulates floral repressors including MAF4 and MAF5 (PubMed:23733063), Plays a transcription activation role in anther development, Regulates the expression of arabinogalactan proteins (AGPs) involved in the formation of the nexine layer of the pollen wall (PubMed:25336567, PubMed:24804694), Binds AGP6, AGP11, AGP23 and AGP40 promoters (PubMed:25336567)


This is Transcription factor PAR1 protein, from Mouse-ear cress, contains 118 amino acids, locates in Nucleus.

Atypical bHLH transcription factor that acts as negative regulator of a variety of shade avoidance syndrome (SAS) responses, including seedling elongation and photosynthetic pigment accumulation, Acts as direct transcriptional repressor of two auxin-responsive genes, SAUR15 and SAUR68, May function in integrating shade and hormone transcriptional networks in response to light and auxin changes


This is Uridine nucleosidase 1 protein, from Mouse-ear cress, contains 336 amino acids, is soluble, locates in Cytoplasm.

Involved in purine and pyrimidine breakdown rather than in pyrimidine salvage, especially in response to dark stress (PubMed:19293370, PubMed:21235647, PubMed:21599668, PubMed:30787180), Together with URH2, required for efficient inosine and xanthosine hydrolytic activities (PubMed:21599668, PubMed:30787180), Unable to use cytidine as a substrate (PubMed:19293370), Can use uridine, inosine, adenosine as well as the cytokinin derivative isopentenyladenine-riboside as substrates (PubMed:19293370), Hydrolyzes also xanthosine with high efficiency (PubMed:21235647)


This is Protein ABSCISIC ACID-INSENSITIVE 5 protein, from Mouse-ear cress, contains 442 amino acids, locates in Nucleus.

Participates in ABA-regulated gene expression during seed development and subsequent vegetative stage by acting as the major mediator of ABA repression of growth, Binds to the embryo specification element and the ABA-responsive element (ABRE) of the Dc3 gene promoter and to the ABRE of the Em1 and Em6 genes promoters, Can also trans-activate its own promoter, suggesting that it is autoregulated, Plays a role in sugar-mediated senescence

Belongs to the bZIP family, ABI5 subfamily


This is V-type proton ATPase subunit a2 protein, from Mouse-ear cress, contains 821 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes, Required for assembly and activity of the V-ATPase, Involved in vacuolar nutrient storage (e,g, accumulation and storage of nitrate) and in tolerance to some toxic ions (e,g, zinc ions sequestration in vacuoles)

Belongs to the V-ATPase 116 kDa subunit family


This is Fructose-bisphosphate aldolase 1, chloroplastic protein, from Mouse-ear cress, contains 399 amino acids, is soluble, locates in Plastid.

Plays a key role in glycolysis and gluconeogenesis

Belongs to the class I fructose-bisphosphate aldolase family


This is Epimerase family protein SDR39U1 homolog, chloroplastic protein, from Mouse-ear cress, contains 347 amino acids, is membrane-bound, locates in Plastid.

Putative NADP-dependent oxidoreductase that acts as positive regulator of chloroplast division, May play a role at an early stage of the division process


This is CDT1-like protein a, chloroplastic protein, from Mouse-ear cress, contains 571 amino acids, locates in Plastid.

Member of the pre-replication complex, Component of the plastid division machinery, Promotes polyloidization and regulates endoreduplication, Involved in the coordination of cell and plastid division


This is Protein root UVB sensitive 2, chloroplastic protein, from Mouse-ear cress, contains 433 amino acids, locates in Plastid.

Involved in a root UV-B sensing pathway and in the protection against the hypersensitivity to very low-fluence-rate (VLF) UV-B, RSU1 and RUS2 are probably both negative modulators of the same UV-B perception pathway, which when overstimulated in the roots causes a block to postgermination development, Required for polar auxin transport and to maintain the normal levels of PIN proteins in the root


This is Protein TIC 55, chloroplastic protein, from Mouse-ear cress, contains 539 amino acids, is membrane-bound, locates in Plastid.

Involved in protein precursor import into chloroplasts, Part of the redox regulon consisting of TIC32, TIC 55 and TIC62


This is Transcription factor JUNGBRUNNEN 1 protein, from Mouse-ear cress, contains 275 amino acids, locates in Nucleus.

Transcription factor that binds to the 5'- RRYGCCGT-3' consensus core sequence, Central longevity regulator, Negative regulator of leaf senescence, Modulates cellular H(2)O(2) levels and enhances tolerance to various abiotic stresses through the regulation of DREB2A


This is Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 protein, from Mouse-ear cress, contains 641 amino acids, is membrane-bound, locates in Cell membrane.

Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates, Acting as a counterplayer of BIR1, promotes the activation of plant defense and cell death (PubMed:19616764), Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity (PubMed:27251392), Functions as an inhibitor/regulator of abscission, probably by regulating membrane trafficking during abscission (PubMed:20081191)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Jasmonoyl--L-amino acid synthetase JAR1 protein, from Mouse-ear cress, contains 575 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the synthesis of jasmonates-amino acid conjugates by adenylation; can use Ile and, in vitro at least, Val, Leu and Phe as conjugating amino acids on jasmonic acid (JA) and 9,10-dihydro-JA substrates, and to a lower extent, on 3-oxo-2-(2Z-pentenyl)-cyclopentane-1-butyric acid (OPC-4) and 12-hydroxy-JA (12-OH-JA), Can synthesize adenosine 5-tetraphosphate in vitro, Required for the JA-mediated signaling pathway that regulates many developmental and defense mechanisms, including growth root inhibition, vegetative storage proteins (VSPs) accumulation, induced systemic resistance (ISR), response to wounding and herbivores, tolerance to ozone O(3) (probably having a role in lesion containment), Plays an important role in the accumulation of JA-Ile in response to wounding, both locally and systemically; promotes JA responding genes especially in distal part of wounded plants, via the JA-Ile-stimulated degradation of JAZ repressor proteins by the SCF(COI)E3 ubiquitin-protein ligase pathway, Involved in the apoptosis-like programmed cell death (PCD) induced by fungal toxin fumonisin B1-mediated (FB1), Required for volatile compounds (C6-aldehydes and allo-ocimene)-mediated defense activation, Involved in the non-pathogenic rhizobacterium-mediated ISR (defense priming) by P,fluorescens (strains CHAOr and WCS417r) and P,putida LSW17S against infection leaf pathogens such as P,syringae pv, tomato and H,parasitica, Required for the JA-dependent resistance to fungi such as P,irregulare, U,vignae and U,appendiculatus, Necessary to induce systemic resistance against R,solanaceraum and P,syringae pv, tomato with P,oligandrum (a non-pathogenic biocontrol agent) cell wall protein fraction (CWP), Mediates PGIP2 accumulation in response to B,cinerea infection and thus contributes to resistance against this pathogen, Modulates the UV-B alteration of leaves attractiveness to diamondback moths P,xylostella leading to insect oviposition, Involved in the regulation of far-red light influence on development, being an actor of the interplay between light and JA signaling (PubMed:28223489), Seems necessary for the salicylic acid (SA)-mediated, NPR1-independent resistance pathway, May contribute to the chitin-elicited pathway, Contributes to the sensitivity toward F,graminearum

Belongs to the IAA-amido conjugating enzyme family


This is Replication protein A 70 kDa DNA-binding subunit A protein, from Mouse-ear cress, contains 640 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions, Plays an essential role at later stages of meiotic recombination events required for the formation of class I crossovers, Is essential for normal progression through meiosis in pollen mother cells, Is involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses, but does not seem to be required for the repair of meiotic DSBs

Belongs to the replication factor A protein 1 family


This is EIN3-binding F-box protein 1 protein, from Mouse-ear cress, contains 628 amino acids, locates in Nucleus.

Component of SCF(EBF1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1), Regulator of the ethylene signaling cascade by modulating the stability of EIN3 and EIL1 proteins, Confers insensitivity to ethylene


This is Protein PROTON GRADIENT REGULATION 5, chloroplastic protein, from Mouse-ear cress, contains 133 amino acids, is membrane-bound, locates in Plastid.

Involved in the regulation of the cyclic electron flow (CEF) around Photosystem I, Essential for the reduction of PGRL1A by ferredoxin and for photoprotection, Contributes to maximize photosynthesis efficiency after a long dark adaptation via the regulation of non-photochemical quenching (NPQ) (PubMed:32978277)


This is Geranylgeranyl pyrophosphate synthase 4 protein, from Mouse-ear cress, contains 372 amino acids, locates in Endoplasmic reticulum.

Catalyzes the trans-addition of the three molecules of isopentenyl diphosphate (IPP) onto dimethylallyl diphosphate (DMAPP) to form geranylgeranyl diphosphate


This is DELLA protein RGA protein, from Mouse-ear cress, contains 587 amino acids, locates in Nucleus.

Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway, Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes, Positively regulates XERICO expression in seeds, Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway, Compared to other DELLA proteins, it is the most sensitive to GA application, No effect of the BOI proteins on its stability, Its activity is probably regulated by other phytohormones such as auxin and ethylene, attenuation of auxin transport delaying its GA-induced degradation, Involved in the regulation of seed dormancy and germination, including glucose-induced delay of seed germination (PubMed:24989044)

Belongs to the GRAS family, DELLA subfamily


This is Violaxanthin de-epoxidase, chloroplastic protein, from Spinach, contains 472 amino acids, is membrane-bound, locates in Plastid.

Part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts, Catalyzes the two-step mono de-epoxidation reaction, Stereospecific for all-trans xanthophylls, Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II

Belongs to the calycin superfamily, Lipocalin family


This is Monogalactosyldiacylglycerol synthase, chloroplastic protein, from Spinach, contains 522 amino acids, is membrane-bound, locates in Plastid.

Involved in the synthesis of the major structural component of photosynthetic membranes, The 1,2-diacylglycerol substrate preference is 18:2/18:2 > 18:0/18:1 > 18:1/18:1 > 18:1/16:0 > 16:0/18:2 > 18:3/18:3 > 16:0/18:1 > 16:0/16:0 > 18:0/18:0

Belongs to the glycosyltransferase 28 family


This is Bidirectional sugar transporter SWEET11 protein, from Mouse-ear cress, contains 289 amino acids, is membrane-bound, locates in Cell membrane.

Mediates both low-affinity uptake and efflux of sugar across the plasma membrane, Involved in phloem loading by mediating export from parenchyma cells feeding H(+)-coupled import into the sieve element/companion cell complex, thus contributing to the sucrose migration from sites of synthesis in the mesophyll to the phloem (PubMed:22157085, PubMed:24027245, PubMed:25988582), Contributes to seed filling by triggering sucrose efflux involved in the transfer of sugars from seed coat to embryos (PubMed:25988582)

Belongs to the SWEET sugar transporter family


This is Gamma carbonic anhydrase-like 2, mitochondrial protein, from Mouse-ear cress, contains 256 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in complex I assembly in mitochondria and respiration

Belongs to the gamma-class carbonic anhydrase family


This is NAD(P)H-quinone oxidoreductase subunit T, chloroplastic protein, from Mouse-ear cress, contains 249 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable), Required for the accumulation of both the NDH subcomplex A and NDHS (PubMed:21505067)


This is Oxalate--CoA ligase protein, from Mouse-ear cress, contains 514 amino acids, is soluble, locates in Cytoplasm.

Oxalyl-CoA synthetase acting exclusively against oxalate (PubMed:22447686, PubMed:27326693), Follows a two-step reaction mechanism, wherein oxalate first undergoes adenylation by ATP, followed by a thioesterification in the presence of CoA to yield oxalyl-CoA (By similarity), No activity with malonate, succinate, malate, acetate, formate, lactate, glycolate, glyoxylate or glutarate (PubMed:22447686), Required for oxalate degradation, normal seed development and defense against oxalate-producing fungal pathogens (PubMed:22447686)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Receptor-like protein 51 protein, from Mouse-ear cress, contains 431 amino acids, is membrane-bound, locates in Cell membrane.

Involved in plant defense, Required for basal resistance against P,syringae pv, tomato DC3000


This is Malate dehydrogenase, chloroplastic protein, from Mouse-ear cress, contains 403 amino acids, is soluble, locates in Plastid.

Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable), Plays a key role in the metabolism of dark chloroplasts and non-green plastids, Essential for embryo viability (PubMed:24198233, PubMed:24453164), Plays an essential role in heterotrophic metabolism in embryos, and autotrophic metabolism in photosynthetic tissues as well (PubMed:24453164)

Belongs to the LDH/MDH superfamily, MDH type 1 family


This is Transcription factor LUX protein, from Mouse-ear cress, contains 323 amino acids, locates in Nucleus.

Transcription factor that is essential for the generation of the circadian clock oscillation, Is necessary for activation of CCA1 and LHY expression, Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter, Directly regulates the expression of PRR9, a major component of the morning transcriptional feedback circuit, by binding specific sites on PRR9 promoter, Binds to its own promoter, inducing a negative auto-regulatory feedback loop within the core clock, Binds to ELF3 and associates with ELF4 in a diurnal complex which is required for the expression of the growth-promoting transcription factors PIF4 and PIF5 and subsequent hypocotyl growth in the early evening


This is Methyl-CpG-binding domain-containing protein 5 protein, from Mouse-ear cress, contains 182 amino acids, locates in Nucleus.

Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides, In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C), Plays probably a role in gene silencing


This is Metal transporter Nramp3 protein, from Mouse-ear cress, contains 509 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Vacuolar metal transporter involved in intracellular metal homeostasis, Can transport iron (Fe), manganese (Mn) and cadmium (Cd), Regulates metal accumulation under Fe starvation, Acts redundantly with NRAMP4 to mobilize vacuolar Fe and provide sufficient Fe during seed germination, In association with NRAMP4, required for optimal growth and photosynthesis under Mn deficiency, Exports Mn from vacuoles in leaf mesophyll cells, making Mn available for functional photosystem II in chloroplasts, Involved in basal resistance to the bacterial pathogen E,chrysanthemi


This is Mitochondrial import inner membrane translocase subunit TIM17-2 protein, from Mouse-ear cress, contains 243 amino acids, is membrane-bound, locates in Mitochondrion.

Essential component of the TIM17:23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane, Links the inner and outer membranes


This is NADPH-dependent codeinone reductase 1-4 protein, from Opium poppy, contains 321 amino acids, is soluble, locates in Cytoplasm.

NADPH-dependent codeinone reductase involved in biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids natural products (PubMed:10417697, PubMed:29779229, PubMed:15543134), Reduces codeinone to codeine in the penultimate step in morphine biosynthesis (PubMed:10417697, PubMed:29779229, PubMed:15543134, PubMed:22098111), Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor (PubMed:10417697), Converts morphinone to morphine, and neomorphinone to neomorphine (By similarity), Reduces irreversibly neopinone, a spontaneous isomer of codeinone, to neopine; in planta, neopine levels are limited to low levels (PubMed:29779229)

Belongs to the aldo/keto reductase family