This is Developmentally-regulated GTP-binding protein 1 protein, from Human, contains 367 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155), Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155), When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238), Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition, GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639)

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family


This is Ribitol-5-phosphate xylosyltransferase 1 protein, from Human, contains 443 amino acids, is membrane-bound, locates in Golgi apparatus.

Acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage on O-mannosyl glycan (PubMed:27733679, PubMed:29477842) (Probable), Participates in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699, PubMed:27601598, PubMed:27733679) (Probable)


This is Nuclease EXOG, mitochondrial protein, from Human, contains 368 amino acids, is membrane-bound, locates in Mitochondrion.

Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity

Belongs to the DNA/RNA non-specific endonuclease family


This is Probable small intestine urate exporter protein, from Human, contains 497 amino acids, is membrane-bound, locates in Cell membrane.

Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions (PubMed:22460716), Mediates chloride-dependent transport of urate (PubMed:22460716), Mediates sodium-independent high affinity transport of thyroid hormones including L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) (PubMed:30367059, PubMed:34937426), Can actively transport inorganic phosphate into cells via Na(+) cotransport (PubMed:22460716)

Belongs to the major facilitator superfamily, Sodium/anion cotransporter family


This is UDP-N-acetylglucosamine transporter protein, from Human, contains 325 amino acids, is membrane-bound, locates in Golgi apparatus.

Transports diphosphate-N-acetylglucosamine (UDP-GlcNAc) from the cytosol into the lumen of the Golgi apparatus, functioning as an antiporter that exchanges UDP-N-acetyl-alpha-D-glucosamine for UMP (PubMed:10393322), May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate highly branched, multiantennary complex N-glycans and keratan sulfate (PubMed:23766508, PubMed:34981577), However, the exact role of SLC35A3 still needs to be elucidated, it could be a member of a catalytically more efficient multiprotein complex rather than function independently as a single transporter (PubMed:32938718)

Belongs to the nucleotide-sugar transporter family, SLC35A subfamily


This is Sodium/hydrogen exchanger 8 protein, from Human, contains 581 amino acids, is membrane-bound, locates in Golgi apparatus.

Na(+)/H(+) antiporter, Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:15522866), Acts as an Na(+)/H(+) exchanger in the trans-Golgi, Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (PubMed:15522866, PubMed:20719963), In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity), Can also be active at the cell surface of specialized cells, In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (PubMed:34288721), Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (By similarity), Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity)

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2,A,36) family


This is Netrin-G1 protein, from Human, contains 539 amino acids, is membrane-bound, locates in Cell membrane.

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels, Promotes neurite outgrowth of both axons and dendrites


This is TBC1 domain family member 30 protein, from Human, contains 924 amino acids, is membrane-bound, locates in Cell membrane.

GTPase-activating protein (GAP) with broad specificity, Acts as a GAP for RAB3A, Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro


This is Hypoxia-inducible factor 3-alpha protein, from Human, contains 669 amino acids, locates in Cytoplasm.

Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation


This is Long-chain fatty acid transport protein 5 protein, from Human, contains 690 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes (PubMed:20448275, PubMed:20530735), Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates (PubMed:10479480), Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine (PubMed:10749848, PubMed:11980911), Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (PubMed:10749848, PubMed:11980911), In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911), Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Zinc finger protein 256 protein, from Human, contains 627 amino acids, has 15 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor that plays a role in cell proliferation, Requires TRIM28 for its activity

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Glutathione S-transferase kappa 1 protein, from Human, contains 226 amino acids, locates in Peroxisome.

Glutathione S-transferase that catalyzes the conjugation of glutathione to exogenous and endogenous compounds (PubMed:14709161, PubMed:14742434), Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB) (PubMed:14709161)

Belongs to the GST superfamily, Kappa family


This is Probable ATP-dependent RNA helicase DDX52 protein, from Human, contains 599 amino acids, locates in Nucleus.

Required for efficient ribosome biogenesis (By similarity), May control cell cycle progression by regulating translation of mRNAs that contain a terminal oligo pyrimidine (TOP) motif in their 5' UTRs, such as GTPBP4 (By similarity)

Belongs to the DEAD box helicase family, DDX52/ROK1 subfamily


This is G-protein coupled receptor 55 protein, from Human, contains 319 amino acids, is membrane-bound, locates in Cell membrane.

May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity), Receptor for L-alpha-lysophosphatidylinositol (LPI), LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA, Putative cannabinoid receptor, May play a role in bone physiology by regulating osteoclast number and function

Belongs to the G-protein coupled receptor 1 family


This is Inner nuclear membrane protein Man1 protein, from Human, contains 911 amino acids, is membrane-bound, locates in Nucleus.

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins, Antagonizes TGF-beta-induced cell proliferation arrest


This is Kelch domain-containing protein 2 protein, from Human, contains 406 amino acids, locates in Nucleus.

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578, PubMed:30526872), The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:29775578, PubMed:30526872), The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:29775578, PubMed:30526872), The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine (PubMed:26138980, PubMed:30526872), The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation (PubMed:29775578, PubMed:30526872), May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding (PubMed:11384994)


This is Zinc finger protein 281 protein, from Human, contains 895 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, locates in Nucleus.

C2H2-type 4; atypical

Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation, Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones, Not required for establishement and maintenance of ESCs (By similarity), Represses the transcription of a number of genes including GAST, ODC1 and VIM, Binds to the G-rich box in the enhancer region of these genes


This is Sodium- and chloride-dependent glycine transporter 2 protein, from Human, contains 797 amino acids, is membrane-bound, locates in Cell membrane.

Lacks sodium- and chloride-dependent glycine transporter activity

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A5 subfamily


This is Ubiquitin-conjugating enzyme E2 J1 protein, from Human, contains 318 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

(Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 (PubMed:30157886)

Belongs to the ubiquitin-conjugating enzyme family


This is Small ribosomal subunit protein uS2m protein, from Human, contains 296 amino acids, locates in Mitochondrion.

Required for mitoribosome formation and stability, and mitochondrial translation

Belongs to the universal ribosomal protein uS2 family


This is Large ribosomal subunit protein uL11m protein, from Human, contains 192 amino acids, locates in Mitochondrion.

Belongs to the universal ribosomal protein uL11 family


This is Methionine-R-sulfoxide reductase B2, mitochondrial protein, from Human, contains 182 amino acids, locates in Mitochondrion.

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine, While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue, Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance

Belongs to the MsrB Met sulfoxide reductase family


This is Mitochondrial import inner membrane translocase subunit TIM16 protein, from Human, contains 125 amino acids, is membrane-bound, locates in Mitochondrion.

Regulates ATP-dependent protein translocation into the mitochondrial matrix, Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity


This is Vesicle transport protein GOT1B protein, from Human, contains 138 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in fusion of ER-derived transport vesicles with the Golgi complex


This is Hepatoma-derived growth factor-related protein 3 protein, from Human, contains 203 amino acids, locates in Nucleus.

Enhances DNA synthesis and may play a role in cell proliferation


This is BolA-like protein 1 protein, from Human, contains 137 amino acids, is soluble, locates in Extracellular.

Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity), Probably acts together with the monothiol glutaredoxin GLRX5 (PubMed:27532772), May protect cells against oxidative stress (PubMed:22746225)


This is Zinc finger protein 330 protein, from Human, contains 320 amino acids, has 4 C4-type Zinc finger, locates in Nucleus.


This is Chromatin target of PRMT1 protein protein, from Human, contains 248 amino acids, is soluble, locates in Nucleus.

Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA, TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway, The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production, Stimulates DDX39B ATPase and helicase activities, In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939)


This is Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 protein, from Human, contains 626 amino acids, locates in Nucleus.

Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:22056990, PubMed:24336198, PubMed:26294762, PubMed:26431200, PubMed:28229507, PubMed:28834754, PubMed:29670289), Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses, such as HIV-1: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:23602554, PubMed:23601106, PubMed:23364794, PubMed:25038827, PubMed:26101257, PubMed:22056990, PubMed:24336198, PubMed:28229507, PubMed:26294762, PubMed:26431200), Likewise, suppresses LINE-1 retrotransposon activity (PubMed:24035396, PubMed:29610582, PubMed:24217394), Not able to restrict infection by HIV-2 virus; because restriction activity is counteracted by HIV-2 viral protein Vpx (PubMed:21613998, PubMed:21720370), In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools (PubMed:23858451), Phosphorylation at Thr-592 acts as a switch to control dNTPase-dependent and -independent functions: it inhibits dNTPase activity and ability to restrict infection by viruses, while it promotes DNA end resection at stalled replication forks (PubMed:23602554, PubMed:23601106, PubMed:29610582, PubMed:29670289), Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication (PubMed:29670289), Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation (PubMed:27477283, PubMed:29670289), Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (PubMed:29670289), Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity)


This is Lethal(3)malignant brain tumor-like protein 1 protein, from Human, contains 840 amino acids, has 1 CCHHC-type Zinc finger, locates in Nucleus.

CCHHC-type

Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications, PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription, Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes, Also recognizes and binds RB1/RB monomethylated at 'Lys-860', Participates in the ETV6-mediated repression, Probably plays a role in cell proliferation, Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis


This is TRPM8 channel-associated factor 1 protein, from Human, contains 921 amino acids, is membrane-bound, locates in Cell membrane.

Positively regulates the plasma membrane cation channel TRPM8 activity, Involved in the recruitment of TRPM8 to the cell surface, Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner


This is Carbohydrate sulfotransferase 2 protein, from Human, contains 530 amino acids, is membrane-bound, locates in Golgi apparatus.

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands, SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation, Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches, Has no activity toward O-linked sugars, Its substrate specificity may be influenced by its subcellular location, Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains

Belongs to the sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily


This is G-protein-signaling modulator 3 protein, from Human, contains 160 amino acids, is soluble, locates in Cytoplasm.

Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins


This is Mitogen-activated protein kinase kinase kinase kinase 5 protein, from Human, contains 846 amino acids, is soluble, locates in Cytoplasm.

May play a role in the response to environmental stress, Appears to act upstream of the JUN N-terminal pathway

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily


This is Cyanocobalamin reductase / alkylcobalamin dealkylase protein, from Human, contains 282 amino acids, is soluble, locates in Cytoplasm.

Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:18779575, PubMed:19700356, PubMed:21697092, PubMed:25809485), Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle (PubMed:19801555), Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol (PubMed:25535791), The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:21071249, PubMed:27771510), Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether (PubMed:19801555, PubMed:21697092, PubMed:22642810, PubMed:25809485), The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors (PubMed:19801555), Cysteine and homocysteine cannot substitute for glutathione in this reaction (PubMed:19801555)


This is AFG3-like protein 2 protein, from Human, contains 797 amino acids, is membrane-bound, locates in Mitochondrion.

ATP-dependent protease which is essential for axonal and neuron development, In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (PubMed:27642048), Required for paraplegin (SPG7) maturation (PubMed:30252181), After its cleavage by mitochondrial-processing peptidase (MPP), it converts paraplegin into a proteolytically active mature form (By similarity), Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (PubMed:22354088, PubMed:30252181), Involved in the regulation of OMA1-dependent processing of OPA1 (PubMed:32600459, PubMed:30252181), Contributes to the proteolytic degradation of GHITM upon hyperpolarization of mitochondria (PubMed:35912435), Progressive GHITM degradation upon persistent hyperpolarization leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2 (PubMed:35912435)

In the C-terminal section; belongs to the peptidase M41 family


This is Centrosomal protein of 83 kDa protein, from Human, contains 701 amino acids, is soluble, locates in Cytoplasm.

Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly, May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly


This is NEDD8 ultimate buster 1 protein, from Human, contains 615 amino acids, locates in Nucleus.

Specific down-regulator of the NEDD8 conjugation system, Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation, Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2


This is Mitochondrial import inner membrane translocase subunit Tim9 protein, from Human, contains 89 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane, May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane, Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space


This is Mitochondrial import inner membrane translocase subunit Tim13 protein, from Human, contains 95 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane, Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane, Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space, The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins


This is Mannose-1-phosphate guanyltransferase beta protein, from Human, contains 360 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids

Belongs to the transferase hexapeptide repeat family


This is Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta protein, from Human, contains 575 amino acids, locates in Nucleus.

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment


This is MTRF1L release factor glutamine methyltransferase protein, from Human, contains 338 amino acids, locates in Mitochondrion.

N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L

Belongs to the protein N5-glutamine methyltransferase family


This is DnaJ homolog subfamily C member 15 protein, from Human, contains 150 amino acids, is membrane-bound, locates in Mitochondrion.

Negative regulator of the mitochondrial respiratory chain, Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity), Acts as an import component of the TIM23 translocase complex, Stimulates the ATPase activity of HSPA9


This is Mitochondrial pyruvate carrier 1 protein, from Human, contains 109 amino acids, is membrane-bound, locates in Mitochondrion.

Mediates the uptake of pyruvate into mitochondria

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2,A,105) family


This is Immediate early response 3-interacting protein 1 protein, from Human, contains 82 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size (PubMed:33122427), Required for secretion of extracellular matrix proteins (PubMed:33122427), Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (PubMed:33122427), Acts as a regulator of the unfolded protein response (UPR) (By similarity)


This is Photoreceptor-specific nuclear receptor protein, from Human, contains 410 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Orphan nuclear receptor of retinal photoreceptor cells, Transcriptional factor that is an activator of rod development and repressor of cone development, Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit, Enhances rhodopsin expression, Represses M- and S-cone opsin expression

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Spindlin-1 protein, from Human, contains 262 amino acids, locates in Nucleus.

Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2, In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551), Overexpression induces metaphase arrest and chromosomal instability, Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006), May play a role in cell-cycle regulation during the transition from gamete to embryo, Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption


This is Small ribosomal subunit protein mS40 protein, from Human, contains 258 amino acids, locates in Mitochondrion.

Belongs to the bacterial ribosomal protein bS18 family, Mitochondrion-specific ribosomal protein mS40 subfamily


This is Protein O-mannosyl-transferase 1 protein, from Human, contains 747 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues, Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:12369018, PubMed:14699049, PubMed:28512129), Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129)

Belongs to the glycosyltransferase 39 family


This is AP-4 complex subunit beta-1 protein, from Human, contains 739 amino acids, is membrane-bound, locates in Golgi apparatus.

Component of the adaptor protein complex 4 (AP-4), Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection, They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028), AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system, It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons, AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable)

Belongs to the adaptor complexes large subunit family


This is NAD-dependent protein lipoamidase sirtuin-4, mitochondrial protein, from Human, contains 314 amino acids, is soluble, locates in Mitochondrion.

Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase (PubMed:16959573, PubMed:17715127, PubMed:24052263, PubMed:25525879), Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications (PubMed:24052263, PubMed:25525879), Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879), Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity (PubMed:16959573, PubMed:17715127), Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127), In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation (PubMed:23663782), Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782), Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity), Does not seem to deacetylate PC (PubMed:23438705), Controls fatty acid oxidation by inhibiting PPARA transcriptional activation (PubMed:24043310), Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310), Down-regulates insulin secretion (PubMed:17715127)

Belongs to the sirtuin family, Class II subfamily


This is Testis-specific chromodomain protein Y 1 protein, from Human, contains 540 amino acids, locates in Nucleus.

Has histone acetyltransferase activity, with a preference for histone H4


This is Large ribosomal subunit protein mL42 protein, from Human, contains 142 amino acids, locates in Mitochondrion.

Belongs to the mitochondrion-specific ribosomal protein mL42 family


This is Synphilin-1 protein, from Human, contains 919 amino acids, is soluble, locates in Cytoplasm.

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins, Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH, Isoform 2 modulates SNCA monoubiquitination by SIAH1


This is Ubiquitin carboxyl-terminal hydrolase 3 protein, from Human, contains 520 amino acids, has 1 UBP-type Zinc finger, locates in Nucleus.

UBP-type

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B, Required for proper progression through S phase and subsequent mitotic entry, May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites, Associates with the chromatin

Belongs to the peptidase C19 family, USP3 subfamily


This is Potassium voltage-gated channel subfamily E member 2 protein, from Human, contains 123 amino acids, is membrane-bound, locates in Cell membrane.

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits, Modulates the gating kinetics and enhances stability of the channel complex, Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1, Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr), May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current, May associate with HCN1 and HCN2 and increase potassium current, Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505), KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability

Belongs to the potassium channel KCNE family


This is Adenylate kinase isoenzyme 5 protein, from Human, contains 562 amino acids, is soluble, locates in Cytoplasm.

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates, Active on AMP and dAMP with ATP as a donor, When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP, Also displays broad nucleoside diphosphate kinase activity


This is Solute carrier organic anion transporter family member 1B1 protein, from Human, contains 691 amino acids, is membrane-bound, locates in Cell membrane.

Mediates the Na(+)-independent uptake of organic anions (PubMed:10358072, PubMed:15159445, PubMed:17412826), Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (dehydroepiandrosterone 3-sulfate, 17-beta-glucuronosyl estradiol, and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine) (PubMed:10358072, PubMed:10601278, PubMed:10873595, PubMed:12568656, PubMed:15159445, PubMed:15970799, PubMed:16627748, PubMed:17412826, PubMed:12196548, PubMed:11159893, PubMed:19129463, PubMed:26979622), Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210), Involved in the clearance of endogenous and exogenous substrates from the liver (PubMed:10358072, PubMed:10601278), Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540), May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable), Can transport HMG-CoA reductase inhibitors (also known as statins), such as pravastatin and pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:10601278, PubMed:15970799, PubMed:15159445), May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drug methotrexate (PubMed:23243220), May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16627748, PubMed:16624871), Shows a pH-sensitive substrate specificity towards prostaglandin E2 and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463), Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463)

Belongs to the organo anion transporter (TC 2,A,60) family


This is Cytochrome c oxidase assembly protein COX11, mitochondrial protein, from Human, contains 276 amino acids, is membrane-bound, locates in Mitochondrion.

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I


This is MAU2 chromatid cohesion factor homolog protein, from Human, contains 613 amino acids, is soluble, locates in Nucleus.

Plays an important role in the loading of the cohesin complex on to DNA, Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566), Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347)


This is Bis(5'-adenosyl)-triphosphatase ENPP4 protein, from Human, contains 453 amino acids, is membrane-bound, locates in Cell membrane.

Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP, Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells, Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family


This is Zinc fingers and homeoboxes protein 2 protein, from Human, contains 837 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Acts as a transcriptional repressor (PubMed:12741956), Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956), May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity), In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity)


This is Lymphocyte antigen 96 protein, from Human, contains 160 amino acids, is soluble, locates in Extracellular.

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869), Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030), Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581), Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581)


This is Collectin-10 protein, from Human, contains 277 amino acids, is soluble, locates in Extracellular.

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141), Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481)


This is Spindle pole body component alp4 protein, from Fission yeast, contains 784 amino acids, is soluble, locates in Cytoplasm.

Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles


This is Meiotic coiled-coil protein 5 protein, from Fission yeast, contains 968 amino acids, is soluble, locates in Cytoplasm.

Involved in chromosome segregation, Facilitates nuclear oscillation during meiotic prophase I, the 'horsetail' phase, by acting as a dynein anchor, Essential for anchoring dhc1 to the cortex, Required for proper sliding of the microtubules along the cell cortex, which leads to the proper U-turn movement of the nucleus


This is Non-structural maintenance of chromosome element 3 protein, from Fission yeast, contains 328 amino acids, locates in Nucleus.

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks, Plays a critical role in meiosis


This is Lysine-specific histone demethylase 1 protein, from Fission yeast, contains 1000 amino acids, locates in Nucleus.

Catalytic component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Has a role in regulating heterochromatin propagation and euchromatic transcription, Also has a gene activating role

Belongs to the flavin monoamine oxidase family


This is Fanconi-associated nuclease 1 homolog protein, from Fission yeast, contains 703 amino acids, locates in Nucleus.

Nuclease required for the repair of DNA interstrand cross-links (ICL) (PubMed:24192486, PubMed:25319828), Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity)


This is Histone H3-like centromeric protein cnp1 protein, from Fission yeast, contains 120 amino acids, locates in Nucleus.

Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes, Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore, Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation, May serve as an epigenetic mark that propagates centromere identity through replication and cell division


This is mRNA export factor mex67 protein, from Fission yeast, contains 596 amino acids, locates in Cytoplasm.

Involved in the export of mRNA from the nucleus to the cytoplasm


This is Growth/differentiation factor 3 protein, from African clawed frog, contains 354 amino acids, is soluble, locates in Extracellular.

Required for posterior mesoderm formation during embryogenesis, Acts indirectly to suppress head formation by altering mesodermal patterning, Also involved in the establishment of left-right axis asymmetry, acting upstream of nodal/nr-1, Can exert long-range effects in the embryo


This is Cytoplasmic polyadenylation element-binding protein 1 protein, from Zebrafish, contains 559 amino acids, is soluble, locates in Cytoplasm.

Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation and early development, Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (By similarity)


This is Transcription factor 7-like 1-A protein, from Zebrafish, contains 560 amino acids, locates in Nucleus.

Participates in the Wnt signaling pathway, Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence, Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone, Required for head formation and forebrain specification, Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates


This is Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial protein, from Chicken, contains 665 amino acids, is membrane-bound, locates in Mitochondrion.

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Belongs to the FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily


This is Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial protein, from Chicken, contains 290 amino acids, is membrane-bound, locates in Mitochondrion.

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family


This is Meiosis 1 arrest protein protein, from Mouse, contains 529 amino acids, is soluble, locates in Cytoplasm.

Required for meiosis I progression during spermatogenesis


This is Cholesterol 25-hydroxylase protein, from Mouse, contains 298 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097, PubMed:29033131), Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953), May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing (PubMed:9852097), In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (PubMed:9852097), Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome (PubMed:29033131), Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses (By similarity)


This is Thioredoxin reductase 2, mitochondrial protein, from Rat, contains 526 amino acids, locates in Mitochondrion.

Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity), Maintains mitochondrial thioredoxin in a reduced state, May play a role in redox-regulated cell signaling

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family


This is Adhesion G protein-coupled receptor E5 protein, from Mouse, contains 818 amino acids, is membrane-bound, locates in Cell membrane.

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation, Plays an essential role in leukocyte migration

Belongs to the G-protein coupled receptor 2 family, LN-TM7 subfamily


This is Tyrosine-protein kinase transmembrane receptor ROR2 protein, from Mouse, contains 944 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes, It seems to be required for cartilage and growth plate development (PubMed:10700181), Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation, In contrast, has also been shown to have very little tyrosine kinase activity in vitro, May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity)

Belongs to the protein kinase superfamily, Tyr protein kinase family, ROR subfamily


This is NEDD8-activating enzyme E1 regulatory subunit protein, from Rat, contains 534 amino acids, is membrane-bound, locates in Cell membrane.

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme, E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP, E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M, Necessary for cell cycle progression through the S-M checkpoint, Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (PubMed:14557245), The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development

Belongs to the ubiquitin-activating E1 family, ULA1 subfamily


This is Glutathione S-transferase Mu 5 protein, from Rat, contains 225 amino acids, is soluble, locates in Cytoplasm.

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

Belongs to the GST superfamily, Mu family


This is Sodium/myo-inositol cotransporter 2 protein, from Rat, contains 673 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1, Exclusively responsible for apical MI transport and absorption in intestine (PubMed:17932225), Can also transport D-chiro-inositol (DCI) but not L-fucose, Exhibits stereospecific cotransport of both D-glucose and D-xylose, May induce apoptosis through the TNF-alpha, PDCD1 pathway, May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity)

Belongs to the sodium:solute symporter (SSF) (TC 2,A,21) family


This is Angiopoietin-related protein 4 protein, from Mouse, contains 410 amino acids, is soluble, locates in Extracellular.

Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism, Has higher activity in LPL inactivation than the uncleaved protein


This is Phosphatidylserine synthase 2 protein, from Mouse, contains 473 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:10938271, PubMed:23071296, PubMed:12361952), Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (PubMed:10938271, PubMed:23071296), Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (PubMed:23071296), Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (PubMed:23071296)

Belongs to the phosphatidyl serine synthase family


This is PDZ and LIM domain protein 7 protein, from Rat, contains 457 amino acids, is soluble, locates in Cytoplasm.

May function as a scaffold on which the coordinated assembly of proteins can occur, May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues, Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e,g, embryonic flat bones mandible and cranium), and endochondral bone formation (e,g, embryonic long bone development), Plays a role during fracture repair, Involved in BMP6 signaling pathway


This is Dipeptidyl aminopeptidase-like protein 6 protein, from Mouse, contains 804 amino acids, is membrane-bound, locates in Cell membrane.

Promotes cell surface expression of the potassium channel KCND2 (PubMed:22311982), Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:22311982), Has no dipeptidyl aminopeptidase activity (By similarity)


This is Peptidyl-prolyl cis-trans isomerase FKBP9 protein, from Mouse, contains 570 amino acids, is soluble, locates in Endoplasmic reticulum.

PPIases accelerate the folding of proteins during protein synthesis


This is Mitogen-activated protein kinase 15 protein, from Rat, contains 547 amino acids, locates in Nucleus.

Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner, Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation, Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling, Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins, Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion, Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA, Regulates DA transporter (DAT) activity and protein expression via activation of RhoA, In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (By similarity), Also functions in a kinase activity-independent manner as a negative regulator of growth (PubMed:9891064), Phosphorylates in vitro FOS and MBP (PubMed:11875070), During oocyte maturation, plays a key role in the microtubule organization and mei- otic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity), Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (By similarity)

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily


This is Diacylglycerol O-acyltransferase 1 protein, from Mouse, contains 498 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:15834126, PubMed:19028692, PubMed:20876538, PubMed:22493088, PubMed:28420705), Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (By similarity), In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:15834126), Also present in female mammary glands, where it produces fat in the milk (By similarity), May be involved in VLDL (very low density lipoprotein) assembly (By similarity), In contrast to DGAT2 it is not essential for survival (PubMed:11959864), Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:19028692), Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (PubMed:15834126), Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)

Belongs to the membrane-bound acyltransferase family, Sterol o-acyltransferase subfamily


This is Methyl-CpG-binding protein 2 protein, from Mouse, contains 484 amino acids, locates in Nucleus.

Chromosomal protein that binds to methylated DNA, It can bind specifically to a single methyl-CpG pair, It is not influenced by sequences flanking the methyl-CpGs, Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3, Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)


This is Methyl-CpG-binding domain protein 4 protein, from Mouse, contains 554 amino acids, locates in Nucleus.

Mismatch-specific DNA N-glycosylase involved in DNA repair, Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites, Can also remove uracil or 5-fluorouracil in G:U mismatches, Has no lyase activity, Was first identified as methyl-CpG-binding protein


This is Methyl-CpG-binding domain protein 3 protein, from Mouse, contains 285 amino acids, locates in Nucleus.

Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity), Acts as transcriptional repressor and plays a role in gene silencing (By similarity), Does not bind methylated DNA by itself (PubMed:9774669), Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity), Recruits histone deacetylases and DNA methyltransferases (By similarity)


This is Serine/threonine-protein kinase/endoribonuclease IRE2 protein, from Mouse, contains 911 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis, Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] protein, from Rat, contains 292 amino acids, locates in Peroxisome.

Auxiliary enzyme of beta-oxidation, Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome, Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA, Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid

Belongs to the short-chain dehydrogenases/reductases (SDR) family, 2,4-dienoyl-CoA reductase subfamily


This is Eukaryotic translation initiation factor 2-alpha kinase 1 protein, from Mouse, contains 619 amino acids, is soluble, locates in Cytoplasm.

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions (PubMed:11726526, PubMed:12767237, PubMed:16893190), Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock (PubMed:11726526, PubMed:16893190), EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming (PubMed:11726526, PubMed:16893190), Acts as a key sensor of heme-deficiency: in normal conditions, binds hemin via a cysteine thiolate and histidine nitrogenous coordination, leading to inhibit the protein kinase activity (PubMed:16893190), This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell: heme depletion relieves inhibition and stimulates kinase activity, activating the ISR (PubMed:16893190), Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions (PubMed:16893190), In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties (PubMed:11726526, PubMed:11050009, PubMed:15931390), It thereby plays an essential protective role for RBC survival in anemias of iron deficiency (PubMed:11726526), Also activates the ISR in response to mitochondrial dysfunction: HRI/EIF2AK1 protein kinase activity is activated upon binding to the processed form of DELE1 (S-DELE1), thereby promoting the ATF4-mediated reprogramming (By similarity)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily


This is Kelch-like ECH-associated protein 1 protein, from Mouse, contains 624 amino acids, locates in Cytoplasm.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:9887101, PubMed:12682069, PubMed:15282312, PubMed:15367669, PubMed:15581590), KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:9887101, PubMed:12193649, PubMed:14764894), In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:12193649, PubMed:20498371, PubMed:22014577, PubMed:29590092), In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20421418, PubMed:20173742, PubMed:24011591), The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357), The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity)


This is CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial protein, from Chinese hamster, contains 553 amino acids, locates in Mitochondrion.

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin

Belongs to the CDP-alcohol phosphatidyltransferase class-II family


This is Serine/threonine-protein kinase SBK1 protein, from Rat, contains 417 amino acids, is soluble, locates in Cytoplasm.

May be involved in signal-transduction pathways related to the control of brain development


This is Proline-rich receptor-like protein kinase PERK4 protein, from Mouse-ear cress, contains 633 amino acids, is membrane-bound, locates in Cell membrane.

Required during abscisic acid (ABA)-mediated activation of Ca(2+) channels, Regulates ABA signaling pathways, Modulates the expression of genes related to cell elongation and ABA signaling during root growth


This is NADH--cytochrome b5 reductase 1 protein, from Mouse-ear cress, contains 281 amino acids, is membrane-bound, locates in Mitochondrion.

Reductase transferring electrons from NADH to cytochrome b5, Required for the NADH-dependent electron transfer involved in the desaturation and hydroxylation of fatty acids and in the desaturation of sterol precursors, No activity with NADPH as electron donor

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family


This is NAC domain-containing protein 18 protein, from Mouse-ear cress, contains 320 amino acids, locates in Nucleus.

May encode a transcription factor involved in the elaboration of shoot apical meristems (SAM) (Probable), Together with NAC056/NARS1, regulates embryogenesis by regulating the development and degeneration of ovule integuments, a process required for intertissue communication between the embryo and the maternal integument (PubMed:18849494)


This is Malate dehydrogenase 1, mitochondrial protein, from Mouse-ear cress, contains 341 amino acids, is soluble, locates in Mitochondrion.

Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable), Required for carbon dioxide and energy partitioning in leaves, May limit photorespiration during the dark phase (PubMed:20876337, PubMed:27208265), Its activity is essential to shuttle reductants out from the mitochondria to support the photorespiratory flux (PubMed:26889011), Can convert 2-oxoglutarate to (S)-2-hydroxyglutarate in vitro (PubMed:26203119)

Belongs to the LDH/MDH superfamily, MDH type 1 family


This is Thioredoxin M5, chloroplastic protein, from Rice, contains 172 amino acids, locates in Plastid.

Thiol-disulfide oxidoreductase probably involved in the redox regulation of chloroplastic enzymes, Required for chloroplast biogenesis and differentiation, Functions as an electron donor for plastidial 2-Cys peroxiredoxins and participates in hydrogen peroxide scavenging system in chloroplasts, Possesses reducing activity towards insulin disulfide bonds

Belongs to the thioredoxin family, Plant M-type subfamily


This is Arginase 2, chloroplastic/mitochondrial protein, from Mouse-ear cress, contains 344 amino acids, locates in Mitochondrion.

Catalyzes the hydrolysis of L-arginine to urea and L-ornithine, The latter can be utilized in the urea cycle or as a precursor for the synthesis of both polyamines and proline (By similarity), Possesses agmatinase activity, Catalyzes the formation of putrescine from agmatine (PubMed:28716421)


This is Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial protein, from Mouse-ear cress, contains 632 amino acids, is membrane-bound, locates in Mitochondrion.

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Belongs to the FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily


This is Transcription factor ABA-INDUCIBLE bHLH-TYPE protein, from Mouse-ear cress, contains 566 amino acids, locates in Nucleus.

Transcription activator, Regulates positively abscisic acid (ABA) response, Confers drought tolerance and sensitivity to ABA


This is Replication protein A 32 kDa subunit A protein, from Mouse-ear cress, contains 279 amino acids, locates in Nucleus.

Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication, The activity of RPA is mediated by single-stranded DNA binding and protein interactions, Required fo cell division in meristems, Involved in the maintenance of transcriptional epigenetic gene silencing (TGS) at specific loci (including some transposons) by regulating histone H3 acetylation, 'Lys-4' and 'Lys-9' methylation

Belongs to the replication factor A protein 2 family


This is Casparian strip membrane protein 3 protein, from Mouse-ear cress, contains 221 amino acids, is membrane-bound, locates in Cell membrane.

Regulates membrane-cell wall junctions and localized cell wall deposition, Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion

Belongs to the Casparian strip membrane proteins (CASP) family


This is Frataxin, mitochondrial protein, from Mouse-ear cress, contains 187 amino acids, locates in Mitochondrion.

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways (PubMed:17092311), May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+) (PubMed:17092311), May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (PubMed:17092311), Binds to the mitochondrial cysteine desulfurase NIFS1 and increases its activity (PubMed:22511606)


This is GRR1-like protein 1 protein, from Mouse-ear cress, contains 585 amino acids, locates in Nucleus.

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins, Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin-regulated transcription, Involved in embryogenesis regulation by auxin, Confers sensitivity to the virulent bacterial pathogen P,syringae, Mediates glucose repression in yeast


This is Ras-related protein RABD1 protein, from Mouse-ear cress, contains 205 amino acids, is membrane-bound, locates in Golgi apparatus.

Protein transport, Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER)

Belongs to the small GTPase superfamily, Rab family


This is Probable LRR receptor-like serine/threonine-protein kinase RPK1 protein, from Mouse-ear cress, contains 540 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the main abscisic acid-mediated (ABA) signaling pathway and in early ABA perception, Together with RPK2, required for pattern formation along the radial axis (e,g, the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e,g, differentiation of the basal pole during early embryogenesis)


This is DNA mismatch repair protein MLH1 protein, from Mouse-ear cress, contains 737 amino acids, locates in Nucleus.

Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis, Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches, This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis, Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates

Belongs to the DNA mismatch repair MutL/HexB family


This is Glutathione S-transferase U19 protein, from Mouse-ear cress, contains 219 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the glutathionylation of 12-oxophytodienoate (OPDA), In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC), and glutathione peroxidase activity toward cumene hydroperoxide

Belongs to the GST superfamily, Tau family


This is UPF0051 protein ABCI8, chloroplastic protein, from Mouse-ear cress, contains 557 amino acids, locates in Plastid.

Involved in light signaling, probably by mediating the transport and correct distribution of protoporphyrin IX, a chlorophyll precursor, in response to far-red light


This is Calcium-dependent protein kinase 21 protein, from Mouse-ear cress, contains 531 amino acids, is membrane-bound, locates in Cell membrane.

May play a role in signal transduction pathways that involve calcium as a second messenger, Mediates the phosphorylation and activation of the S-type anion efflux channel SLAC1

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDPK subfamily


This is Nitrogen regulatory protein P-II homolog protein, from Mouse-ear cress, contains 196 amino acids, locates in Plastid.

Participates in sensing carbon and organic nitrogen status and regulates some steps of primary carbon and nitrogen metabolism, Required for nitrite uptake in chloroplasts and regulates arginine biosynthesis through interaction with acetylglutamate kinase (NAGK) in chloroplasts, Regulates fatty acids synthesis in chloroplasts by interacting with the acetyl-CoA carboxylase complex and inhibiting acetyl-CoA carboxylase (ACCase) activity


This is FKBP12-interacting protein of 37 kDa protein, from Mouse-ear cress, contains 330 amino acids, locates in Nucleus.

Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs (PubMed:15047892, PubMed:28503769), Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences (PubMed:28503769), N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing (PubMed:15047892, PubMed:28503769), Essential protein required during endosperm development and embryogenesis, Involved in endoreduplication, especially in trichomes, May play a role in splicing events (PubMed:15047892)


This is Metal tolerance protein 1 protein, from Mouse-ear cress, contains 398 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Mediates zinc accumulation in roots and confers resistance to zinc, Involved in sequestration of excess zinc in the cytoplasm into vacuoles to maintain zinc homeostasis, Can also transport cadmium with a low efficiency

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2,A,4) family, SLC30A subfamily


This is Fructose-bisphosphate aldolase 3, chloroplastic protein, from Mouse-ear cress, contains 391 amino acids, is soluble, locates in Plastid.

Plays a key role in glycolysis and gluconeogenesis

Belongs to the class I fructose-bisphosphate aldolase family


This is Vacuolar iron transporter 1 protein, from Mouse-ear cress, contains 250 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Vacuolar iron transporter involved in the transfer of iron ions from the cytosol to the vacuole for intracellular iron storage (PubMed:17082420, PubMed:26232490), Involved in regulation of cellular iron homeostasis (PubMed:17082420, PubMed:26232490), Vacuolar iron storage is required for seed embryo and seedling development (PubMed:17082420, PubMed:26232490) (Probable)


This is Metalloendoproteinase 5-MMP protein, from Mouse-ear cress, contains 360 amino acids, is membrane-bound, locates in Cell membrane.

Matrix metalloproteinases (MMPs) or matrixins may play a role in the degradation and remodeling of the extracellular matrix (ECM) during development or in response to stresses (By similarity), Active on Mca-KESAbuNLFVLKDpaR-NH(2) (QF75) and, to some extent, on McaPLGLDpaAR-NH(2) (QF24), myelin basic protein (MBP) and beta-casein (PubMed:24156403)

Belongs to the peptidase M10A family, Matrix metalloproteinases (MMPs) subfamily


This is Protein CHROMATIN REMODELING 19 protein, from Mouse-ear cress, contains 763 amino acids, locates in Nucleus.

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization, Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity), Probable chromatin remodeling factor, Probable helicase-like transcription factor involved in transcriptional gene silencing, Associates with SUVR2 and contributes to transcriptional gene silencing at RNA-directed DNA methylation (RdDM) target loci but also at RdDM-independent target loci, May be involved in nucleosome positioning to form ordered nucleosome arrays on chromatin (PubMed:25420628)

Belongs to the SNF2/RAD54 helicase family


This is RNA-binding protein CP29B, chloroplastic protein, from Mouse-ear cress, contains 289 amino acids, locates in Plastid.

Could be involved in splicing and/or processing of chloroplast RNA's


This is Protein FAR1-RELATED SEQUENCE 3 protein, from Mouse-ear cress, contains 851 amino acids, has 1 SWIM-type Zinc finger, locates in Nucleus.

SWIM-type

Putative transcription activator involved in regulating light control of development


This is Serrate RNA effector molecule protein, from Mouse-ear cress, contains 720 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery, Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs, Does not participate in sense post-transcriptional gene silencing, Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression, Its function is however not limited to miRNA-mediated repression of leaf polarity genes, but rather acts as a general regulator of primary microRNAs processing, Also critical for the accumulation of the trans-acting small interfering RNA (ta-siRNA), Required for pre-mRNA splicing


This is Protein argonaute 4 protein, from Mouse-ear cress, contains 924 amino acids, is soluble, locates in Nucleus.

Together with RDM3, required for transcriptional gene silencing (TGS) by DNA methylation and repressive histone modifications (H3K9me2) of several chromatin loci (PubMed:21738482), Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats, Forms a AGO4/NRPE1/siRNA complex in cajal body, facilitating its function in RNA-directed gene silencing of target loci, Required for CpNpG and asymmetric DNA methylation as well as histone H3 'Lys-9' methylation (H3K9me) at SUP and SN1 loci, May be not required for CpG methylation, Required for the production and maintenance of retrotransposon SN1 and Copia and ribosomal 5S 25 nucleotide siRNAs specialized in gene silencing at chromatin level, Involved in de novo methylation of FWA gene and required for the maintenance of RNA-directed DNA methylation (RdDM) triggered by inverted repeat transgenes, Interacts with miRNA miR390 and miR172, targeting respectively TAS3 and AP2 mRNAs, and mediates cleavage of miRNA targets, Associates mainly with small RNAs of 24 nucleotide in length and preferentially recruits small RNAs with a 5' terminal adenosine, Targeted by the turnip yellows virus (TuYV) protein P0 (via F-box-like domain) for probable proteasome degradation and thereby inactivating AGO4 function in RNA silencing, Required for resistance to the bacterial pathogen P,syringae, Works independently of the RdDM pathway in mediating resistance to P,syringae, RdDM is involved in viral genome methylation as an epigenetic defense against geminiviruses (PubMed:12522258, PubMed:14988555, PubMed:15242620, PubMed:16839878, PubMed:16839879, PubMed:16998468, PubMed:17869110, PubMed:17938239, PubMed:17993621, PubMed:18342361, PubMed:18596098, PubMed:19377477, PubMed:20173091)

Belongs to the argonaute family, Ago subfamily


This is Phytyl ester synthase 1, chloroplastic protein, from Mouse-ear cress, contains 704 amino acids, is soluble, locates in Plastid.

Acyltransferase involved in fatty acid phytyl ester synthesis in chloroplasts, a process required for the maintenance of the photosynthetic membrane integrity during abiotic stress and senescence (PubMed:22623494), Exhibits phytyl ester synthesis and diacylglycerol acyltransferase activities with broad substrate specificities, and can employ acyl-CoAs, acyl carrier proteins, and galactolipids as acyl donors (PubMed:22623494)

Belongs to the diacylglycerol acyltransferase family


This is DExH-box ATP-dependent RNA helicase DExH10 protein, from Mouse-ear cress, contains 995 amino acids, is soluble, locates in Nucleus.

ATP-dependent RNA helicase that associates with the RNA exosome complex, with the cap binding complex (CBC) and with the NEXT-like complex, Involved in the degradation of a large number of non-coding nuclear exosome substrates such as snoRNA and miRNA precursors, incompletely spliced mRNAs, and spurious transcripts produced from pseudogenes and intergenic regions (PubMed:25144737), Involved in the maintenance of homeotic B and C gene expression in the reproductive whorls, Regulates floral organ spacing and identity, probably through the regulation of protein synthesis or mRNA degradation (PubMed:11923195)

Belongs to the DExH box helicase family, SKI2 subfamily


This is 3-isopropylmalate dehydratase small subunit 2 protein, from Mouse-ear cress, contains 256 amino acids, is soluble, locates in Plastid.

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (Probable), Functions redundantly with LEUD2 in the methionine chain elongation pathway of aliphatic glucosinolate formation


This is 3-isopropylmalate dehydratase small subunit 1 protein, from Mouse-ear cress, contains 251 amino acids, is soluble, locates in Plastid.

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (PubMed:19597944), Plays an essential role in leucine biosynthesis (PubMed:19597944, PubMed:20663849, PubMed:24608865, PubMed:32612621), Functions in both the biosynthesis of leucine, and in the methionine chain elongation pathway of aliphatic glucosinolate formation (PubMed:24608865), Plays an essential role in female gametophyte development (PubMed:19597944, PubMed:20663849, PubMed:24608865)


This is Two-component response regulator ARR2 protein, from Mouse-ear cress, contains 664 amino acids, locates in Nucleus.

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3', Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system, Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes, Could directly activate some type-A response regulators in response to cytokinins, Involved in the expression of nuclear genes for components of mitochondrial complex I, Promotes cytokinin-mediated leaf longevity, Involved in the ethylene signaling pathway in an ETR1-dependent manner and in the cytokinin signaling pathway

Belongs to the ARR family, Type-B subfamily


This is Lipoyl synthase, mitochondrial protein, from Mouse-ear cress, contains 374 amino acids, locates in Mitochondrion.

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (PubMed:9808738, PubMed:24872381) (By similarity), Together with LIP2 is essential for mitochondrial protein lipoylation during seed development, Required for the lipoylation of mitochondrial pyruvate dehydrogenase component E2 proteins in leaves and roots (PubMed:24872381)

Belongs to the radical SAM superfamily, Lipoyl synthase family


This is Maternal embryonic leucine zipper kinase protein, from Caenorhabditis elegans, contains 706 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants (PubMed:16774992, PubMed:20929735, PubMed:23946438, PubMed:23267054, PubMed:23851392, PubMed:28659600), Plays a role in neural fate specification in several dopaminergic linages, acting in concert with ham-1 (PubMed:28659600), Involved in phosphorylation of multiple proteins associated with key developmental processes, including the cell cycle, apoptosis, endocytosis, and asymmetric cell division (PubMed:28659600), Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface (PubMed:22801495), May act downstream of par-4/strd-1/mop-25 to regulate cell shedding (PubMed:22801495)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is Alpha-L-arabinofuranosidase B protein, from Penicillium canescens, contains 463 amino acids, is soluble, locates in Extracellular.

Secreted alpha-L-arabinofuranosidase that actively hydrolyzes p-NP-alpha-L-arabinofuranoside and is specific for furanose configuration of the carbohydrate ring, Exhibits also significant activity against polymeric arabinose-containing substrates such as arabinan and arabinoxylan, a major component of plant hemicellulose

Belongs to the glycosyl hydrolase 54 family


This is Pyranose dehydrogenase protein, from Poison yellow meadow mushroom, contains 600 amino acids, is soluble, locates in Extracellular.

Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin, The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity, Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor, May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization

Belongs to the GMC oxidoreductase family


This is L-amino acid oxidase protein, from Horned desert viper, contains 516 amino acids, is soluble, locates in Extracellular.

Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (PubMed:25009089), Is highly active on L-Met>L-Leu>L-Phe>L-Trp=L-Ile (PubMed:25009089), Binds to the cell surface and enables the production of highly localized concentration of hydrogen peroxide in or near the binding interfaces (PubMed:26433175), Does not bind to phospholipids (PubMed:26433175), Induces platelet-rich plasma aggregation, shows cytotoxic effects on some cancer cell lines (B16-F10 (mouse melanoma), PC12 (rat pheochromocytoma), MCF-7 and MDA-MB-231 (human breast carcinoma)) and shows antibacterial activities against both Gram-positive and Gram-negative bacteria (PubMed:26433175), Also exhibits hemorrhage and edema (By similarity), Does not show cytotoxicity on erythrocytes and peripheral blood mononuclear cells (PubMed:26433175), Its effect on platelets is controversial, since it either induces aggregation or inhibits agonist-induced aggregation, These different effects are probably due to different experimental conditions

Belongs to the flavin monoamine oxidase family, FIG1 subfamily


This is Cell pattern formation-associated protein ust1 protein, from Corn smut fungus, contains 624 amino acids, locates in Nucleus.

Transcription factor that regulates asexual reproduction (PubMed:25208341), Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (By similarity), Regulates dimorphism, virulence, and the sporulation program (PubMed:20064064), Required for mating, gall induction, and sporogenesis in maize tissue (PubMed:20064064), Regulates expression of the filament-down-regulated gene UM00205 and the teliospore-specific gene ssp1 (PubMed:20064064)


This is Brevinin-2GHb protein, from Gunther's frog, contains 72 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide, Active against the Gram-positive bacteria S,aureus FDA209P (MIC=16,5 ug/ml) and B,subtilis ATCC 6633 (MIC>64 ug/ml), and the Gram-negative bacteria E,coli O111 (MIC=8,2 ug/ml) and E,coli ATCC 25922 (MIC=8,2 ug/ml), Not active against the fungus C,albicans

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is Brevinin-2GHc protein, from Gunther's frog, contains 72 amino acids, is soluble, locates in Extracellular.

Antimicrobial peptide, Active against the Gram-positive bacteria S,aureus FDA209P (MIC=9,8 ug/ml) and B,subtilis ATCC 6633 (MIC>64 ug/ml), and the Gram-negative bacteria E,coli O111 (MIC=19,6 ug/ml) and E,coli ATCC 25922 (MIC=9,8 ug/ml), Not active against the fungus C,albicans


This is Basal body-orientation factor 1 protein, from African clawed frog, contains 531 amino acids, is soluble, locates in Cytoplasm.

Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow, May act by mediating a maturation step that stabilizes and aligns cilia orientation, Not required to respond to planar cell polarity (PCP) or flow-based orientation cues


This is Neoverrucotoxin subunit alpha protein, from Reef stonefish, contains 703 amino acids, is soluble, locates in Extracellular.

Has hemolytic and lethal activities, Its hemolytic activity is inhibited by anionic lipids, especially potently by cardiolipin


This is Neoverrucotoxin subunit beta protein, from Reef stonefish, contains 700 amino acids, is soluble, locates in Extracellular.


This is RNA-binding protein MEX3A protein, from Human, contains 520 amino acids, has 1 RING-type Zinc finger, locates in Cytoplasm.

RING-type

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms


This is Protein CLT2, chloroplastic protein, from Mouse-ear cress, contains 431 amino acids, is membrane-bound, locates in Plastid.

Involved in thiol transport from the plastid to the cytosol, Transports probably both glutathione (GSH) and its precursor, gamma-glutamylcysteine (gamma-EC)

Belongs to the CRT-like transporter family


This is Alpha-xylosidase A protein, from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513), contains 736 amino acids, is soluble, locates in Extracellular.

Catalyzes the liberation of alpha-xylose from the non-reducing terminal glucose of xyloglucan oligosaccharides

Belongs to the glycosyl hydrolase 31 family


This is Bifunctional protein FolD 1, mitochondrial protein, from Mouse-ear cress, contains 352 amino acids, locates in Mitochondrion.

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family


This is Protein starmaker protein, from Zebrafish, contains 613 amino acids, is soluble, locates in Extracellular.

Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration, May be one of the organic components of the ortholiths


This is Growth-regulating factor 1 protein, from Rice, contains 396 amino acids, locates in Nucleus.

Transcription activator that plays a regulatory role in gibberellin-induced stem elongation


This is Cyclin-B2-2 protein, from Rice, contains 419 amino acids, locates in Nucleus.

Involved in the control of the cell cycle at the G2/M (mitosis) transition, May associate to CDKB2-1 and activate CDKB2-1 kinase to promote cell division

Belongs to the cyclin family, Cyclin AB subfamily


This is Zinc transporter 8 protein, from Rice, contains 390 amino acids, is membrane-bound, locates in Cell membrane.

Zinc transporter that may mediate zinc uptake from the rhizosphere and may be responsible for the translocation of zinc within the plant

Belongs to the ZIP transporter (TC 2,A,5) family


This is Mitochondrial import receptor subunit TOM40B protein, from Rat, contains 308 amino acids, is membrane-bound, locates in Mitochondrion.

Potential channel-forming protein implicated in import of protein precursors into mitochondria


This is Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform protein, from Bovine, contains 467 amino acids, is soluble, locates in Cytoplasm.

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment

Belongs to the phosphatase 2A regulatory subunit B56 family


This is B3 domain-containing protein LFL1 protein, from Rice, contains 402 amino acids, locates in Nucleus.

Transcription repressor involved in flowering time regulation, Represses the flowering activator EHD1 by binding specifically to the DNA sequence 5'-CATGCATG-3 of its promoter


This is Facilitated trehalose transporter Tret1 protein, from Sleeping chironomid midge, contains 504 amino acids, is membrane-bound, locates in Cell membrane.

High-capacity facilitative transporter for trehalose, required to induce anhydrobiosis, Anhydrobiotic larvae can survive almost complete dehydration, Does not transport maltose, sucrose or lactose, Mediates the bidirectional transfer of trehalose, Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Trehalose transporter subfamily


This is Protein leg1a protein, from Zebrafish, contains 364 amino acids, is soluble, locates in Extracellular.

Important for early development of liver, exocrine pancreas and intestine, probably through cell cycle regulation, In liver, its function is partially redundant with leg1b function


This is Keratin, type I cytoskeletal 28 protein, from Mouse, contains 462 amino acids, is soluble, locates in Cytoplasm.

Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs)

Belongs to the intermediate filament family


This is Venom prothrombin activator vestarin-D1 protein, from Lesser black whip snake, contains 473 amino acids, is soluble, locates in Extracellular.

Snake prothrombin activator that attacks the hemostatic system of prey, This protein is functionally similar to blood coagulation factor Xa (By similarity)

Belongs to the peptidase S1 family, Snake venom subfamily


This is Venom prothrombin activator vestarin-D2 protein, from Lesser black whip snake, contains 471 amino acids, is soluble, locates in Extracellular.


This is Endochitinase 46 protein, from Hypocrea lixii, contains 430 amino acids, is soluble, locates in Extracellular.

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods), Plays a morphogenetic role during apical growth, cell division and differentiation (cell wall morphogenesis), Acts also as an antifungal agent, Involved in the degradation and further assimilation of phytopathogenic fungi, namely mycoparasitism, the major mechanism accounting for the antagonistic activity against phytopathogenic fungi displayed by Trichoderma

Belongs to the glycosyl hydrolase 18 family, Chitinase class V subfamily


This is Modulator of macroautophagy TMEM150B protein, from Human, contains 233 amino acids, is membrane-bound, locates in Cell membrane.

Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859), Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859), May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859)


This is Nuclear protein 2 protein, from Human, contains 97 amino acids, locates in Nucleus.

Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells (PubMed:25899918), Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation (PubMed:25899918), Plays a role as a negative regulator of the protumoral factor NUPR1 (PubMed:25899918)


This is C2 calcium-dependent domain-containing protein 4B protein, from Human, contains 364 amino acids, locates in Nucleus.

May be involved in inflammatory process, May regulate cell architecture and adhesion


This is Mu-conotoxin cal12a protein, from California cone, contains 87 amino acids, is soluble, locates in Extracellular.

Mu-conotoxins block voltage-gated sodium channels (Nav), This toxin reversibly blocks voltage-gated sodium channel in cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation, Has no effect on sodium channels of the two gastropod S,luhuanus and A,californica (which are not natural prey)