This is 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial protein, from Baker's yeast, contains 307 amino acids, is membrane-bound, locates in Mitochondrion.

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

Belongs to the class I-like SAM-binding methyltransferase superfamily, MenG/UbiE family


This is Metalloproteinase inhibitor 1 protein, from Yellow baboon, contains 207 amino acids, is soluble, locates in Extracellular.

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor, Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16, Does not act on MMP14, Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1, Plays a role in integrin signaling

Belongs to the protease inhibitor I35 (TIMP) family


This is Nuclear receptor subfamily 2 group C member 2 protein, from Human, contains 596 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Orphan nuclear receptor that can act as a repressor or activator of transcription, An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways, May regulate gene expression during the late phase of spermatogenesis, Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1, Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, Plays a fundamental role in early embryonic development and embryonic stem cells, Required for normal spermatogenesis and cerebellum development, Appears to be important for neurodevelopmentally regulated behavior (By similarity), Activates transcriptional activity of LHCG, Antagonist of PPARA-mediated transactivation

Belongs to the nuclear hormone receptor family, NR2 subfamily


This is Beta-diguetoxin-Dc1a protein, from Desert bush spider, contains 94 amino acids, is soluble, locates in Extracellular.

Insecticidal toxin (PubMed:8541888, PubMed:8896202), This toxin promotes opening of insect Nav channels, The toxin binds to the S1-S2 and S3-S4 loops in the domain II voltage-sensor of insect Nav channels (i,e,, receptor site 4), The American cockroach P,americana is largely resistant to the effects of this toxin due to an unusual sequence within the domain II S1-S2 loop, In vivo, paralyzes lepidopteran and dipteran larvae, Paralyzed insects ultimately die from secondary effects of starvation and dehydration (PubMed:25014760)

Belongs to the neurotoxin 26 (DTX) family


This is Deoxyribonuclease-1-like 1 protein, from Human, contains 302 amino acids, locates in Endoplasmic reticulum.


This is CX3C chemokine receptor 1 protein, from Human, contains 355 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Acts as coreceptor with CD4 for HIV-1 virus envelope protein (PubMed:14607932), May have more potent HIV-1 coreceptor activity than isoform 1 (PubMed:14607932)

Belongs to the G-protein coupled receptor 1 family


This is Ethylene receptor 1 protein, from Mouse-ear cress, contains 738 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Ethylene receptor related to bacterial two-component regulators, Acts as a redundant negative regulator of ethylene signaling (PubMed:15466228, PubMed:15703053), In the presence of ethylene, the auto-kinase activity of ETR1 is inhibited and the non-phosphorylated kinase domain binds tightly to the corresponding domain of EIN2 (PubMed:20591837)


This is Protein Wnt-4 protein, from African clawed frog, contains 351 amino acids, is soluble, locates in Extracellular.

Ligand for members of the frizzled family of seven transmembrane receptors, Plays an important role in embryonic kidney development, Acts downstream of Notch signaling during pronephric kidney development, During early pronephros development, patterns the proximal pronephric anlagen to promote glomus and nephrostome formation, Also required later in pronephros development for tubulogenesis


This is Tyrosine-protein phosphatase non-receptor type 7 protein, from Rat, contains 359 amino acids, is soluble, locates in Cytoplasm.

May play a role in the regulation of T and B-lymphocyte development and signal transduction

Belongs to the protein-tyrosine phosphatase family, Non-receptor class subfamily


This is Glutamate dehydrogenase 2, mitochondrial protein, from Human, contains 558 amino acids, is soluble, locates in Mitochondrion.

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

Belongs to the Glu/Leu/Phe/Val dehydrogenases family


This is Alpha-tocopherol transfer protein protein, from Human, contains 278 amino acids, is soluble, locates in Cytoplasm.

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897), Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity)


This is CCAAT/enhancer-binding protein alpha protein, from Human, contains 358 amino acids, locates in Nucleus.

Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation

Belongs to the bZIP family, C/EBP subfamily


This is Ribonucleoside-diphosphate reductase small chain 2 protein, from Baker's yeast, contains 345 amino acids, locates in Nucleus.

Provides the precursors necessary for DNA synthesis, Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides, RNR4 is required for proper folding of RNR2 and assembly with the large subunits

Belongs to the ribonucleoside diphosphate reductase small chain family


This is Acyl-coenzyme A thioesterase 2, mitochondrial protein, from Human, contains 483 amino acids, locates in Mitochondrion.

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16940157, PubMed:10944470), Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:16940157, PubMed:10944470), The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity)

Belongs to the C/M/P thioester hydrolase family


This is Protein cornichon protein, from Fruit fly, contains 144 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Acts as cargo receptor necessary for the transportation of gurken (grk) to a transitional endoplasmic reticulum (tER) site and promotes its incorporation into coat protein complex II (COPII) vesicles, Associated with gurken, produces a signal received by torpedo resulting in a signaling pathway that first establishes posterior follicle cell fates and normal localization of the anterior and posterior determinants, later they act in a signaling event inducing dorsal follicle cell fates and regulating the dorsal-ventral pattern of egg and embryo


This is Protein Wnt-11b protein, from African clawed frog, contains 353 amino acids, is soluble, locates in Extracellular.

Ligand for the frizzled7 transmembrane receptor, Primarily acts via non-canonical Wnt pathways mediated by either Ca(2+) and PKC, or by JNK and dvl2/dsh, Depending on the cellular context, can also signal via the canonical Wnt pathway mediated by beta-catenin and dvl2/dsh, May also inhibit canonical Wnt signaling, Maternally initiates dorsal/ventral axis formation by a canonical route, which signals via lrp6, In a complex with wnt5a, activates the canonical and non-canonical processes involved in axis formation, In the non-canonical pathway, acts through fzd7/fz7 to induce phosphorylation of dvl2/dsh, Signals through a non-canonical Wnt pathway to regulate convergent extension movements during gastrulation, Interactions with the secreted Wnt antagonist sfrp5 to coordinate foregut development, acting via a non-canonical Wnt pathway whereby sfrp5 restricts wnt11b activity to prevent inappropriate foregut formation, Mediates cardiogenesis via non-canonical Wnt signaling involving JNK-activation and PKC, Acts redundantly with wnt11/wnt11r during pronephros induction


This is Double-strand break repair protein MRE11 protein, from Human, contains 708 amino acids, locates in Nucleus.

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289), The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289), RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289), This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738), The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416), In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888)


This is Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase protein, from Baker's yeast, contains 525 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation, Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol

Belongs to the ALG10 glucosyltransferase family


This is Prohibitin-2 protein, from Baker's yeast, contains 310 amino acids, is membrane-bound, locates in Mitochondrion.

Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins


This is Mitochondrial prohibitin complex protein 2 protein, from Caenorhabditis elegans, contains 294 amino acids, is membrane-bound, locates in Mitochondrion.

PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad, A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells (PubMed:12794069), Required for clearance of paternal mitochondria after embryonic fertilization (PubMed:28017329)


This is Inosine-5'-monophosphate dehydrogenase 4 protein, from Baker's yeast, contains 524 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth


This is Inosine-5'-monophosphate dehydrogenase 3 protein, from Baker's yeast, contains 523 amino acids, is soluble, locates in Cytoplasm.


This is Transcription initiation factor TFIID subunit 4 protein, from Baker's yeast, contains 388 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID, Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription


This is DNA-directed RNA polymerase I subunit RPA14 protein, from Baker's yeast, contains 137 amino acids, locates in Nucleus.

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors, RPA14 seems to play a role in the stability of subunits RPO26 and RPA43, In vitro, the RPA14-RPA43 subcomplex binds single-stranded RNA


This is Homeobox protein Nkx-2.1 protein, from Mouse, contains 372 amino acids, locates in Nucleus.

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor, Crucial in the maintenance of the thyroid differentiation phenotype, May play a role in lung development and surfactant homeostasis, Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271), Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression, Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123)


This is Homeobox protein MOX-2 protein, from Human, contains 304 amino acids, locates in Nucleus.

Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity), Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity), May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity), Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000), Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000), While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000), Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity)


This is Carnitine O-palmitoyltransferase 1, liver isoform protein, from Human, contains 773 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:9691089, PubMed:11350182, PubMed:14517221), Plays an important role in hepatic triglyceride metabolism (By similarity)

Belongs to the carnitine/choline acetyltransferase family


This is Serine/threonine-protein kinase ssp1 protein, from Fission yeast, contains 652 amino acids, is soluble, locates in Cytoplasm.

Involved in actin localization and thus in polarized cell growth

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Serine/threonine-protein kinase shk1/pak1 protein, from Fission yeast, contains 658 amino acids, is soluble, locates in Cytoplasm.

MAP4K component of the MAPK pathway required for the mating pheromone response, Phosphorylates histone H2B to form H2BS10ph (By similarity), Phosphorylates tea1, Required for skb1-dependent mitotic inhibitory function, Regulates microtubule dynamics and cell polarity

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily


This is Checkpoint protein rad17 protein, from Fission yeast, contains 606 amino acids, locates in Nucleus.

Participates in checkpoint pathways arrest of the cell cycle, A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes


This is Gamma-aminobutyric acid receptor subunit beta-1 protein, from Mouse, contains 474 amino acids, is membrane-bound, locates in Cell membrane.

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain, Functions also as histamine receptor and mediates cellular responses to histamine (By similarity), Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site, Functions as ligand-gated chloride channel

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Gamma-aminobutyric acid receptor (TC 1,A,9,5) subfamily, GABRB1 sub-subfamily


This is Methionine aminopeptidase 2 protein, from Human, contains 478 amino acids, is soluble, locates in Cytoplasm.

Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR, Plays a critical role in the regulation of protein synthesis

Belongs to the peptidase M24A family, Methionine aminopeptidase eukaryotic type 2 subfamily


This is SUMO-conjugating enzyme UBC9 protein, from Baker's yeast, contains 157 amino acids, locates in Nucleus.

E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA, Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2)

Belongs to the ubiquitin-conjugating enzyme family


This is Potassium voltage-gated channel subfamily A member 5 protein, from Rabbit, contains 598 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient, The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:7556635), Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity), Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:7556635), Homotetrameric channels display rapid activation and slow inactivation (PubMed:7556635), May play a role in regulating the secretion of insulin in normal pancreatic islets (By similarity)

Belongs to the potassium channel family, A (Shaker) (TC 1,A,1,2) subfamily, Kv1,5/KCNA5 sub-subfamily


This is 6,7-dimethyl-8-ribityllumazine synthase protein, from Baker's yeast, contains 169 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate, This is the penultimate step in the biosynthesis of riboflavin


This is Transcriptional regulatory protein PHO23 protein, from Baker's yeast, contains 330 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


This is T-complex protein 1 subunit theta protein, from Human, contains 548 amino acids, is soluble, locates in Cytoplasm.

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444), The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444), As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638), The TRiC complex plays a role in the folding of actin and tubulin (Probable)


This is AMP deaminase protein, from Fission yeast, contains 831 amino acids, is soluble, locates in Cytoplasm.

AMP deaminase plays a critical role in energy metabolism

Belongs to the metallo-dependent hydrolases superfamily, Adenosine and AMP deaminases family


This is RNA-binding protein FXR1 protein, from Human, contains 621 amino acids, is soluble, locates in Cytoplasm.

mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis (PubMed:17382880, PubMed:20417602, PubMed:30067974, PubMed:34731628, PubMed:35989368, PubMed:36306353), Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:17382880, PubMed:34731628), Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity), Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity), Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site (PubMed:34731628), Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (PubMed:30067974), Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity), Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity), Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity), Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity), Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (PubMed:30770808), Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (PubMed:32706158)


This is Sodium-dependent noradrenaline transporter protein, from Bovine, contains 615 amino acids, is membrane-bound, locates in Cell membrane.

Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:8150077), Can also mediate sodium- and chloride-dependent transport of dopamine (By similarity)

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family, SLC6A2 subfamily


This is Fos-related antigen 2 protein, from Rat, contains 326 amino acids, locates in Nucleus.

Controls osteoclast survival and size (By similarity), As a dimer with JUN, activates LIF transcription (By similarity), Activates CEBPB transcription in PGE2-activated osteoblasts (PubMed:15299028)

Belongs to the bZIP family, Fos subfamily


This is Amiloride-sensitive sodium channel subunit gamma protein, from Human, contains 649 amino acids, is membrane-bound, locates in Cell membrane.

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride, Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells, Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus, Controls the reabsorption of sodium in kidney, colon, lung and sweat glands, Also plays a role in taste perception

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family, SCNN1G subfamily


This is Amiloride-sensitive sodium channel subunit delta protein, from Human, contains 802 amino acids, is membrane-bound, locates in Cell membrane.

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride, Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells, Controls the reabsorption of sodium in kidney, colon, lung and sweat glands, Also plays a role in taste perception

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family, SCNN1D subfamily


This is Protoporphyrinogen oxidase protein, from Mouse, contains 477 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX

Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family, Protoporphyrinogen oxidase subfamily


This is Small ribosomal subunit protein mS29 protein, from Human, contains 398 amino acids, locates in Mitochondrion.

Involved in mediating interferon-gamma-induced cell death

Belongs to the mitochondrion-specific ribosomal protein mS29 family


This is Nuclear receptor ROR-alpha protein, from Mouse, contains 523 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence, Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism, Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively, Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts, Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1, Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction, Regulates the circadian expression of several clock genes, including CLOCK, BMAL1, NPAS2 and CRY1, Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression, Therefore influences the period length and stability of the clock, Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG, In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1, Induces a rhythmic expression of some of these genes, In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism, Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC1 and PCK1, In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms, May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding, Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus, Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A, May inhibit cell growth in response to cellular stress, May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Nuclear receptor ROR-gamma protein, from Human, contains 518 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches, Required for the generation of LTi (lymphoid tissue inducer) cells, Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2, Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus, May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus


This is Nuclear receptor ROR-gamma protein, from Mouse, contains 516 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches (PubMed:10602018, PubMed:14691482, PubMed:16148126), Required for the generation of LTi (lymphoid tissue inducer) cells, Regulates thymocyte survival through DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2, Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program, Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus (PubMed:16990136, PubMed:18164222, PubMed:26607793), May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regulation of DNA accessibility in the TCR-J(alpha) locus (PubMed:9881970, PubMed:10602018, PubMed:14691482, PubMed:16148126, PubMed:16990136, PubMed:18164222), Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (By similarity)


This is Dual specificity protein phosphatase 3 protein, from Human, contains 185 amino acids, locates in Nucleus.

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines, Specifically dephosphorylates and inactivates ERK1 and ERK2

Belongs to the protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily


This is Steroidogenic acute regulatory protein, mitochondrial protein, from Mouse, contains 284 amino acids, locates in Mitochondrion.

Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone, Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion


This is B-cell receptor-associated protein 31 protein, from Human, contains 246 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Functions as a chaperone protein (PubMed:9396746, PubMed:18287538), Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538), Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538), Also serves as a cargo receptor for the export of transmembrane proteins (By similarity), Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022), In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022), May be involved in CASP8-mediated apoptosis (PubMed:10958671)


This is Ubiquitin-conjugating enzyme E2 D1 protein, from Human, contains 147 amino acids, is soluble, locates in Cytoplasm.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338), In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386), Mediates the selective degradation of short-lived and abnormal proteins, Functions in the E6/E6-AP-induced ubiquitination of p53/TP53, Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941), Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044), Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044), Essential for viral activation of IRF3 (PubMed:19854139), Mediates polyubiquitination of CYP3A4 (PubMed:19103148)


This is C-C chemokine receptor type 5 protein, from Human, contains 352 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1

Belongs to the G-protein coupled receptor 1 family


This is H(+)/Cl(-) exchange transporter 7 protein, from Human, contains 805 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911), Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284), The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity), The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)

Belongs to the chloride channel (TC 2,A,49) family, ClC-7/CLCN7 subfamily


This is H(+)/Cl(-) exchange transporter 7 protein, from Rat, contains 803 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189), Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (By similarity), The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:18449189), The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity)


This is Nuclear receptor subfamily 0 group B member 1 protein, from Human, contains 470 amino acids, locates in Cytoplasm.

Orphan nuclear receptor, Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis, Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions, May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity)

Belongs to the nuclear hormone receptor family, NR0 subfamily


This is Teratocarcinoma-derived growth factor protein, from Mouse, contains 171 amino acids, is membrane-bound, locates in Cell membrane.

GPI-anchored cell membrane protein involved in Nodal signaling, Cell-associated Tdgf1 acts as a Nodal coreceptor in cis, Shedding of Tdgf1 by Tmem8a modulates Nodal signaling by allowing soluble Tdgf1 to act as a Nodal coreceptor on other cells, Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm

Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family


This is Sodium-dependent serotonin transporter protein, from Fruit fly, contains 622 amino acids, is membrane-bound, locates in Cell membrane.

Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2,A,22) family


This is Cyclin-G1 protein, from Human, contains 295 amino acids, locates in Nucleus.

May play a role in growth regulation, Is associated with G2/M phase arrest in response to DNA damage, May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity)

Belongs to the cyclin family, Cyclin G subfamily


This is Ubiquitin-conjugating enzyme E2 E1 protein, from Human, contains 193 amino acids, locates in Nucleus.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, Catalyzes the covalent attachment of ISG15 to other proteins, Mediates the selective degradation of short-lived and abnormal proteins, In vitro also catalyzes 'Lys-48'-linked polyubiquitination

Belongs to the ubiquitin-conjugating enzyme family


This is NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 protein, from Human, contains 172 amino acids, is membrane-bound, locates in Mitochondrion.

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867), Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371), The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371)

Belongs to the complex I NDUFA8 subunit family


This is GTP-binding protein YPT32/YPT11 protein, from Baker's yeast, contains 222 amino acids, is membrane-bound, locates in Golgi apparatus.

Required for protein transport through the secretory pathway, Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment, Mediates the proper polarized localization of SEC2, a GEF for SEC4, but does not alter the exchange activity of SEC2 on SEC4, Plays a role in autophagy

Belongs to the small GTPase superfamily, Rab family


This is Peptidyl-prolyl cis-trans isomerase 5 protein, from Caenorhabditis elegans, contains 204 amino acids, is soluble, locates in Cytoplasm.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Belongs to the cyclophilin-type PPIase family


This is Calreticulin protein, from Bovine, contains 417 amino acids, is soluble, locates in Endoplasmic reticulum.

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle, This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER, Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity), Involved in maternal gene expression regulation, May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity), Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)


This is Calmegin protein, from Mouse, contains 611 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida, Required for normal sperm migration from the uterus into the oviduct, Required for normal male fertility, Binds calcium ions


This is Heterogeneous nuclear ribonucleoprotein M protein, from Human, contains 730 amino acids, locates in Nucleus.

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro, Involved in splicing, Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines


This is Serine/threonine-protein kinase polo protein, from Fruit fly, contains 576 amino acids, is soluble, locates in Cytoplasm.

May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (PubMed:1660828), Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles (PubMed:24829288), Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules (PubMed:24829288)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDC5/Polo subfamily


This is DNA-directed RNA polymerases I, II, and III subunit RPABC3 protein, from Human, contains 150 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively

Belongs to the eukaryotic RPB8 RNA polymerase subunit family


This is DNA-directed RNA polymerase II subunit RPB11-a protein, from Human, contains 117 amino acids, locates in Nucleus.

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs, Pol II is the central component of the basal RNA polymerase II transcription machinery, It is composed of mobile elements that move relative to each other, RPB11 is part of the core element with the central large cleft (By similarity)

Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family


This is Rho GDP-dissociation inhibitor 1 protein, from Human, contains 204 amino acids, is soluble, locates in Cytoplasm.

Controls Rho proteins homeostasis, Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them, Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation, Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms, Through the modulation of Rho proteins, may play a role in cell motility regulation, In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1


This is Rho GDP-dissociation inhibitor 2 protein, from Human, contains 201 amino acids, is soluble, locates in Cytoplasm.

Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369), Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133)


This is Cationic amino acid transporter 2 protein, from Human, contains 658 amino acids, is membrane-bound, locates in Cell membrane.

Functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine)

Belongs to the amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2,A,3,3) family


This is Zinc finger protein 131 protein, from Human, contains 623 amino acids, has 5 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger, locates in Nucleus.

C2H2-type 4; degenerate

Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity), May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling

Belongs to the krueppel C2H2-type zinc-finger protein family


This is RNA-binding protein 5 protein, from Human, contains 815 amino acids, has 1 RanBP2-type Zinc finger, has 1 C2H2-type; atypical Zinc finger, locates in Nucleus.

C2H2-type; atypical

Component of the spliceosome A complex, Regulates alternative splicing of a number of mRNAs, May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron, May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2, In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis, In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis


This is Ephrin-A5 protein, from Human, contains 228 amino acids, is membrane-bound, locates in Cell membrane.

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development, Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor, This signaling event requires the activity of the Fyn tyrosine kinase, Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization, With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance, May function actively to stimulate axon fasciculation, The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion, Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion


This is Homeobox protein unc-30 protein, from Caenorhabditis elegans, contains 323 amino acids, locates in Nucleus.

Transcriptional regulator within D-type neurons that controls terminal differentiation (PubMed:7997265), Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid-secreting) D-type motor neurons, which control locomotion (PubMed:7997265), Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1 (PubMed:26083757), Also required for expression of flp-13 in DD motor neurons (PubMed:15882588), Plays a role in respecification of DD motor neurons through regulation of genes involved in the modulation of cellular cAMP including pde-4 which hydrolyzes cAMP and acy-1 which catalyzes cAMP formation (PubMed:29033363)

Belongs to the paired homeobox family, Bicoid subfamily


This is High mobility group protein HMGI-C protein, from Mouse, contains 108 amino acids, locates in Nucleus.

Functions as a transcriptional regulator, Functions in cell cycle regulation through CCNA2, Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes, Plays a role in postnatal myogenesis, is involved in satellite cell activation (PubMed:27446912), Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (By similarity)


This is Mannosyl-oligosaccharide glucosidase protein, from Baker's yeast, contains 833 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically (PubMed:9363442), Seems to play a role in beta-1,6-glucan synthesis (PubMed:8576053)

Belongs to the glycosyl hydrolase 63 family


This is Replication factor C subunit 2 protein, from Fruit fly, contains 331 amino acids, locates in Nucleus.

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1, Subunit 2 binds ATP

Belongs to the activator 1 small subunits family


This is Serine/threonine-protein phosphatase T protein, from Baker's yeast, contains 513 amino acids, locates in Nucleus.

Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90 (HSC82 and HSP82), Dephosphorylation positively regulates the Hsp90 chaperone machinery

Belongs to the PPP phosphatase family, PP-5 (PP-T) subfamily


This is Oligo-1,6-glucosidase IMA1 protein, from Baker's yeast, contains 589 amino acids, locates in Mitochondrion.

Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization, Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides, Does not hydrolyze maltose

Belongs to the glycosyl hydrolase 13 family


This is RNA polymerase-associated protein RTF1 protein, from Baker's yeast, contains 558 amino acids, is soluble, locates in Nucleus.

The PAF1 complex is a multifunctional complex, Involved in transcription initiation via genetic interactions with TATA-binding proteins, Involved in elongation, It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II, Also has a role in transcription-coupled histone modification, Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B, Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2, Important for TATA site selection by TBP, Directly or indirectly regulates the DNA-binding properties of SPT15, the TATA box-binding protein, and the relative activities of different TATA elements


This is Aromatic/aminoadipate aminotransferase 1 protein, from Baker's yeast, contains 500 amino acids, is soluble, locates in Cytoplasm.

General aromatic amino acid transaminase involved in several otherwise unrelated metabolic pathways, Responsible for phenylalanine and tyrosine biosynthesis, Active with glutamate, phenylalanine, tyrosine and tryptophan as amino donors and with phenylpyruvate, hydroxyphenylpyruvate, 2-oxoglutarate and pyruvate as amino acceptors, Also active with methionine, alpha-aminoadipate and leucine as amino donors when phenylpyruvate is the amino acceptor and in the reverse reactions with the corresponding oxo acids and phenylalanine as amino donor, Catalyzes the formation of methionine from 2-keto-4-methylthiobutyrate (KMTB) in the methionine salvage pathway primarily using aromatic amino acids (tyrosine, phenylalanine and tryptophan) as the amino donors, Catalyzes the formation of alpha-aminoadipate from alpha-ketoadipate in the lysine biosyntheic pathway

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is RQC trigger complex subunit CUE3 protein, from Baker's yeast, contains 624 amino acids, is soluble, locates in Cytoplasm.

Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:28223409, PubMed:32203490, PubMed:36627279), Specifically recognizes and binds RPS20/uS10 ubiquitinated by HEL2, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes (PubMed:28757607, PubMed:36627279)


This is RNA-binding protein RMD9, mitochondrial protein, from Baker's yeast, contains 646 amino acids, is membrane-bound, locates in Mitochondrion.

Binds the RNA motif 5'-AAUAA[U/C]AUUCUU-3' in the 3'-UTR of mitochondrial mRNAs (PubMed:33876744, PubMed:10441495, PubMed:10905425), Involved in the processing or stability of mitochondrial mRNAs (PubMed:33876744, PubMed:17194787, PubMed:17194786)


This is Large subunit GTPase 1 protein, from Baker's yeast, contains 640 amino acids, is soluble, locates in Cytoplasm.

GTPase required for the nuclear export of the 60S ribosomal subunit, Acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm

Belongs to the TRAFAC class YlqF/YawG GTPase family, LSG1 subfamily


This is Protein transport protein USE1 protein, from Baker's yeast, contains 245 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER


This is Mitochondrial pyruvate carrier 1 protein, from Baker's yeast, contains 130 amino acids, is membrane-bound, locates in Mitochondrion.

Mediates the uptake of pyruvate into mitochondria

Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2,A,105) family


This is Large ribosomal subunit protein bL12m protein, from Baker's yeast, contains 194 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the bacterial ribosomal protein bL12 family


This is ATP-dependent RNA helicase MRH4, mitochondrial protein, from Baker's yeast, contains 561 amino acids, locates in Mitochondrion.

ATP-binding RNA helicase involved in mitochondrial RNA metabolism, Required for maintenance of mitochondrial DNA

Belongs to the DEAD box helicase family, MRH4 subfamily


This is [Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial protein, from Baker's yeast, contains 491 amino acids, is soluble, locates in Mitochondrion.

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit (PDA1), thus contributing to the regulation of glucose metabolism

Belongs to the PDK/BCKDK protein kinase family


This is Glutamine sensor PIB2 protein, from Baker's yeast, contains 635 amino acids, has 1 FYVE-type; atypical Zinc finger, is membrane-bound, locates in Lysosome/Vacuole.

FYVE-type; atypical

Functions as an intracellular glutamine sensor that directly activates the TORC1 signaling pathway, to promote cell growth when glutamine is available (PubMed:34535752, PubMed:29698392, PubMed:28483912, PubMed:26510498, PubMed:32801125), May play a role in repressing NPR1 activity independently of TORC1 signaling (PubMed:28993463)


This is SWR1-complex protein 4 protein, from Baker's yeast, contains 476 amino acids, locates in Nucleus.

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling, Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair


This is Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 protein, from Baker's yeast, contains 395 amino acids, locates in Nucleus.

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:12597897), Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD), Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis (By similarity), Predominantly acts in the salvage pathways via NMN (PubMed:11884393)

Belongs to the eukaryotic NMN adenylyltransferase family


This is Ethanol acetyltransferase 1 protein, from Baker's yeast, contains 328 amino acids, locates in Mitochondrion.

Alcohol acetyltransferase that catalyzes the synthesis of ethyl acetate from ethanol and acetyl-CoA (PubMed:28356220), Can also function as a thioesterase by hydrolyzing acetyl-CoA in the absence of ethanol, as well as esterase hydrolyzing ethyl acetate (By similarity)


This is Ribonucleases P/MRP protein subunit POP6 protein, from Baker's yeast, contains 158 amino acids, locates in Nucleus.

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends, Also a component of RNase MRP, which cleaves pre-rRNA sequences


This is Protein ORM1 protein, from Baker's yeast, contains 222 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the SPOTS complex that acts as a negative regulator of sphingolipid synthesis, Acts by inhibiting serine palmitoyltransferases (LCB1 and LCB2) activity


This is Phosphatidate cytidylyltransferase, mitochondrial protein, from Baker's yeast, contains 385 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane, Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane


This is Ribosome biogenesis protein SLX9 protein, from Baker's yeast, contains 210 amino acids, locates in Nucleus.

Involved in ribosome biogenesis, Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1), May be involved in the movements of the replication forks


This is Pescadillo homolog protein, from Baker's yeast, contains 605 amino acids, is soluble, locates in Nucleus.

Component of the NOP7 complex, which is required for maturation of the 25S and 5,8S ribosomal RNAs and formation of the 60S ribosome


This is Cardiolipin-specific deacylase 1, mitochondrial protein, from Baker's yeast, contains 445 amino acids, locates in Mitochondrion.

Mitochondrial cardiolipin-specific phospholipase which deacylates de novo synthesized cardiolipin (CL), Part of the remodeling process of cardiolipin, which involves deacylation-reacylation of premature cardiolipin, Has a strong substrate preference for palmitic acid residues and generates monolysocardiolipin (MLCL) for TAZ1-dependent reacylation with unsaturated fatty acids (PubMed:19244244, PubMed:23637464), The hydrolytic selectivity of the enzyme toward C16-CL substrates contributes to the preservation of C18:1-containing CL species (PubMed:27982579), Has high specificity towards peroxidized cardiolipids CL(OX), Required to mitigate oxidative stress by removing CL(OX) (PubMed:29935382)

Belongs to the peptidase S33 family, ABHD4/ABHD5 subfamily


This is Conserved oligomeric Golgi complex subunit 2 protein, from Baker's yeast, contains 262 amino acids, is membrane-bound, locates in Golgi apparatus.

Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking, COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events, COG2 is required for ER to Golgi vesicle docking, Not essential for viability


This is U3 small nucleolar RNA-associated protein 8 protein, from Baker's yeast, contains 713 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Also has a role in nuclear tRNA export, It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus, Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs)


This is Pre-mRNA-splicing factor SYF2 protein, from Baker's yeast, contains 215 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing and cell cycle control, As a component of the NTC complex (or PRP19-associated complex), associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation, The cell cycle arrest of SYF2 defective cells may be due to the inefficient splicing of TUB1


This is GTP-binding protein GTR2 protein, from Baker's yeast, contains 341 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions (PubMed:26510498, PubMed:15989961, PubMed:32801125, PubMed:28993463), Also required for TORC1 inactivation during nitrogen starvation (PubMed:28993463), Required for intracellular sorting of GAP1 out of the endosome (PubMed:16732272), Involved in the regulation of microautophagy (PubMed:15989961)

Belongs to the GTR/RAG GTP-binding protein family


This is Mitochondrial import inner membrane translocase subunit TIM13 protein, from Baker's yeast, contains 105 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane, Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane, Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space, The TIM8-TIM13 complex is non essential and only mediates the import of few proteins under precise conditions while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins, Strictly required for import of TIM23 in some conditions, when a low membrane potential exists in the mitochondria


This is Nucleolar protein 19 protein, from Baker's yeast, contains 196 amino acids, locates in Nucleus.

Ribosome biogenesis factor required for cleavage of pre-rRNA at A0, A1 and A2 sites, Essential for the incorporation of UTP25 in pre-ribosomes


This is Steryl acetyl hydrolase 1 protein, from Baker's yeast, contains 424 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for the deacetylation of acetylated sterols, Involved in the resistance to eugenol and pregnenolone toxicity

Belongs to the 'GDXG' lipolytic enzyme family


This is Probable family 17 glucosidase SCW4 protein, from Baker's yeast, contains 386 amino acids, is soluble, locates in Extracellular.

Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation

Belongs to the glycosyl hydrolase 17 family


This is Protein PXR1 protein, from Baker's yeast, contains 271 amino acids, locates in Nucleus.

Involved in rRNA-processing at A0, A1 and A2 sites through its action in U18 and U24 snoRNA 3'-end final trimming, Negative regulator of telomerase through competition for binding to EST2 with TLC1


This is Aspartic proteinase MKC7 protein, from Baker's yeast, contains 596 amino acids, is membrane-bound, locates in Cell membrane.

Cleaves proteins C-terminally to the most C-terminal basic residue, Can process the alpha-mating factor precursor, Required for cell wall integrity


This is RNA polymerase II subunit A C-terminal domain phosphatase SSU72 protein, from Baker's yeast, contains 206 amino acids, locates in Nucleus.

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1)


This is m7GpppN-mRNA hydrolase protein, from Baker's yeast, contains 970 amino acids, is soluble, locates in Cytoplasm.

Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:10508173, PubMed:11139489, PubMed:11741542), Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12554866), Decapping is the major pathway of mRNA degradation in yeast and occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (PubMed:10508173, PubMed:11139489, PubMed:11741542), Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:19779198)

Belongs to the Nudix hydrolase family, DCP2 subfamily


This is CCAAT/enhancer-binding protein alpha protein, from Mouse, contains 359 amino acids, locates in Nucleus.

Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation

Belongs to the bZIP family, C/EBP subfamily


This is CCAAT/enhancer-binding protein gamma protein, from Mouse, contains 150 amino acids, locates in Nucleus.

Transcription factor that binds to the promoter and the enhancer regions of target genes (PubMed:21602272), Binds to the promoter and the enhancer of the immunoglobulin heavy chain (PubMed:2121606), Binds to GPE1, a cis-acting element in the G-CSF gene promoter (PubMed:1709121), Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity), Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity)


This is Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial protein, from Baker's yeast, contains 329 amino acids, locates in Mitochondrion.

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:9874242), The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit (By similarity)

Belongs to the succinate/malate CoA ligase alpha subunit family


This is Probable secreted beta-glucosidase SUN4 protein, from Baker's yeast, contains 420 amino acids, is soluble, locates in Extracellular.

Involved in the remodeling of the cell wall during the various phases of yeast culture development and under various environmental conditions and plays a role in septation


This is Poly(A) RNA polymerase protein 2 protein, from Baker's yeast, contains 584 amino acids, locates in Nucleus.

Catalytic subunit of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information, Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met, Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome, TRF4 is also required for proper nuclear division in mitosis, DNA damage repair and sister chromatid cohesion, Involved in the regulation of histone mRNA levels, May mediate mitotic chromosome condensation

Belongs to the DNA polymerase type-B-like family


This is Prenylated Rab acceptor 1 protein, from Baker's yeast, contains 176 amino acids, is membrane-bound, locates in Golgi apparatus.


This is NAD-dependent protein deacetylase HST1 protein, from Baker's yeast, contains 503 amino acids, locates in Nucleus.

NAD-dependent histone deacetylase involved in telomeric silencing, Histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Restores silencing at HMR in SIR2 mutants when overexpressed, Required to repress middle sporulation genes during vegetative growth, Acts as a sensor of NAD(+) levels and regulator of NAD(+) biosynthesis, Regulates the gene expression of de novo NAD(+) biosynthesis genes

Belongs to the sirtuin family, Class I subfamily


This is NAD-dependent histone deacetylase HST4 protein, from Baker's yeast, contains 370 amino acids, locates in Nucleus.

NAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance


This is Mitochondrial inner membrane protease ATP23 protein, from Baker's yeast, contains 227 amino acids, is membrane-bound, locates in Mitochondrion.

Has a dual role in the assembly of mitochondrial ATPase, Acts as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(0) subunit 6 (ATP6) at the intermembrane space side, Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of ATP6 with the subunit 9 ring


This is ATP-dependent RNA helicase DBP6 protein, from Baker's yeast, contains 629 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5,8S rRNAs

Belongs to the DEAD box helicase family, DDX51/DBP6 subfamily


This is Nucleolar GTP-binding protein 2 protein, from Baker's yeast, contains 486 amino acids, locates in Nucleus.

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation

Belongs to the TRAFAC class YlqF/YawG GTPase family, NOG2 subfamily


This is Pre-rRNA-processing protein ESF2 protein, from Baker's yeast, contains 316 amino acids, locates in Nucleus.

Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis, Required for the early cleavages at sites A0, A1 and A2, Stimulates DBP8 RNA helicase ATPase activity


This is Phosphatidylcholine-sterol acyltransferase protein, from Rabbit, contains 440 amino acids, is soluble, locates in Extracellular.

Central enzyme in the extracellular metabolism of plasma lipoproteins, Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs), The cholesterol ester is then transported back to the liver, Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels, Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins, Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity), Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107), Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity), Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity), Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity)

Belongs to the AB hydrolase superfamily, Lipase family


This is Pre-mRNA-splicing factor CWC24 protein, from Baker's yeast, contains 259 amino acids, has 1 C3H1-type Zinc finger, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type


This is Phosphatidylinositol transfer protein PDR17 protein, from Baker's yeast, contains 350 amino acids, is soluble, locates in Cytoplasm.

Has phosphatidylinositol transfer activity, Involved in the regulation of the phospholipid composition of plasma- and endomembranes, Altering plasma membrane composition may provide a possible mechanism for multidrug resistance, Contributes to efficient phospholipase D1 activation and phospholipase B1 inhibition in the regulation of phospholipid turnover, Forms a complex with phosphatidylserine decarboxylase PSD2 that seems essential for maintenance of vacuolar phosphatidylethanolamine (PE) levels (PubMed:20016005)


This is Protein transport protein DSL1 protein, from Baker's yeast, contains 754 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for protein transport between the Golgi and the endoplasmic reticulum, May tether coatomer-coated retrograde transport vesicles to the ER membrane through interaction with coatomer as well as the SNARE complex, May contribute to the stabilization of the SNARE complex


This is Folic acid synthesis protein FOL1 protein, from Baker's yeast, contains 824 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes three sequential steps of tetrahydrofolate biosynthesis

In the C-terminal section; belongs to the DHPS family


This is Vacuolar protein sorting-associated protein 75 protein, from Baker's yeast, contains 264 amino acids, locates in Nucleus.

Histone chaperone which acts as a cofactor stimulating histone H3 acetylation by RTT109 (PubMed:21256037, PubMed:17320445, PubMed:31387991, PubMed:29300933, PubMed:19172748), Preferentially stimulates histone H3 'Lys-9' acetylation by RTT109 (PubMed:21256037, PubMed:31387991, PubMed:29300933), May also stimulate histone H3 'Lys-56' acetylation by RTT109 (PubMed:17320445), Assembles nucleosomes (in vitro) (PubMed:19172748)

Belongs to the nucleosome assembly protein (NAP) family


This is Pre-rRNA-processing protein IPI3 protein, from Baker's yeast, contains 555 amino acids, locates in Nucleus.

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA

Belongs to the WD repeat IPI3/WDR18 family


This is Protein ASI2 protein, from Baker's yeast, contains 289 amino acids, is membrane-bound, locates in Nucleus.

Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain, Required for ERG11 degradation (PubMed:25236469), Negative regulator of SPS-sensor signaling, Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:17085444), Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748)


This is GPI mannosyltransferase 2 subunit PGA1 protein, from Baker's yeast, contains 198 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential component of the GPI mannosyltransferase 2 complex, Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly


This is Chromatin modification-related protein EAF7 protein, from Baker's yeast, contains 425 amino acids, locates in Nucleus.

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A, The NuA4 complex is also involved in DNA repair


This is H/ACA ribonucleoprotein complex non-core subunit NAF1 protein, from Baker's yeast, contains 492 amino acids, locates in Nucleus.

RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis, During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex, Acts as a competitive binder for CBF5 probably required to prevent non-cognate RNAs from being loaded during transport of the particle by inducing a non-productive conformation of CBF5


This is Pro-apoptotic serine protease NMA111 protein, from Baker's yeast, contains 997 amino acids, locates in Nucleus.

Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1


This is E3 ubiquitin-protein ligase DMA2 protein, from Baker's yeast, contains 522 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjunction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugating enzymes, Involved in nutritional control of the cell cycle, Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck


This is Phosphatidate phosphatase APP1 protein, from Baker's yeast, contains 587 amino acids, is soluble, locates in Cytoplasm.

Mg(2+)-dependent phosphatidate (PA) phosphatase which catalyzes the dephosphorylation of PA to yield diacylglycerol, May play a role in vesicular trafficking through its PAP activity at cortical actin patches (PubMed:23071111, PubMed:23335564), Can also utilize diacylglycerol pyrophosphate and lyso-PA as substrates with specificity constants 4- and 7-fold lower, respectively, when compared with PA (PubMed:23335564)


This is U3 small nucleolar ribonucleoprotein protein IMP4 protein, from Baker's yeast, contains 290 amino acids, locates in Nucleus.

Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing


This is GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase protein, from Baker's yeast, contains 548 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for N-linked oligosaccharide assembly, Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum

Belongs to the glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily


This is Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2 protein, from Baker's yeast, contains 656 amino acids, is membrane-bound, locates in Cell membrane.

Together with SLM1, effector of the TORC2- and calcineurin-signaling pathways, Phosphorylated and activated by TORC2 under favorable growth conditions, Mediates actin polarization via inhibition of calcineurin-dependent transcription, Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin, inhibiting interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization, Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis


This is Inositol phosphatase SIW14 protein, from Baker's yeast, contains 281 amino acids, is soluble, locates in Cytoplasm.

Selectively cleaves the beta-phosphate at the 5-position of soluble inositol pyrophosphates, Converts 5-diphosphoinositol tetrakisphosphate (5-PP-InsP(4)) into inositol pentakisphosphate (InsP(5)), 5-diphosphoinositol pentakisphosphate (5-PP-IP(5) or 5-InsP(7)) into inositol hexakisphosphate (IP(6) or InsP(6)), and 1,5-bisdiphosphoinositol tetrakisphosphate (1,5-PP-IP(5) or InsP(8)) into 1-diphosphoinositol pentakisphosphate (1-PP-IP(5) or 1-InsP(7)) (PubMed:26828065, PubMed:29540476), Modulates inositol pyrophosphate metabolism that may have an influence in stress response (PubMed:26828065), Plays a role in actin filament organization and endocytosis (PubMed:15020461), Functions as a prion suppressing factor possibly due to its phosphatase activity against inositol pyrophosphates, which are signal transduction molecules involved in prion propagation (PubMed:28923943)

Belongs to the protein-tyrosine phosphatase family


This is Sorting assembly machinery 50 kDa subunit protein, from Baker's yeast, contains 484 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the mitochondrial outer membrane sorting assembly machinery (SAM or TOB) complex, which is required for the sorting of proteins with complicated topology, such as beta-barrel proteins, to the mitochondrial outer membrane after import by the TOM complex


This is 25S rRNA (cytosine(2278)-C(5))-methyltransferase protein, from Baker's yeast, contains 490 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 2278 (m5C2278) in 25S rRNA (PubMed:23913415, PubMed:25125595, PubMed:25635753), Loss of m5C2278 in 25S rRNA results in anisomycin hypersensitivity (PubMed:23913415)

Belongs to the class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family


This is Probable ERAD-associated E3 ubiquitin-protein ligase ASI1 protein, from Baker's yeast, contains 676 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Nucleus.

RING-type; atypical


This is Monocarboxylate transporter 1 protein, from Human, contains 500 amino acids, is membrane-bound, locates in Cell membrane.

Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:33333023, PubMed:32946811), Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023), The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate, MCT1 is a major lactate exporter (By similarity), Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity), Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811), Functions via alternate outward- and inward-open conformation states, Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023)

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is Monocarboxylate transporter 1 protein, from Mouse, contains 493 amino acids, is membrane-bound, locates in Cell membrane.

Bidirectional proton-coupled monocarboxylate transporter, Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (By similarity), The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate, MCT1 is a major lactate exporter (By similarity), Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (PubMed:22522610, PubMed:24367518), Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart, Functions via alternate outward- and inward-open conformation states, Protonation and deprotonation of 302-Asp is essential for the conformational transition (By similarity)


This is Monocarboxylate transporter 1 protein, from Rat, contains 494 amino acids, is membrane-bound, locates in Cell membrane.

Bidirectional proton-coupled monocarboxylate transporter, Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH, The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate, MCT1 is a major lactate exporter (PubMed:9374487, PubMed:9639576, PubMed:10417314, PubMed:19473976, PubMed:8526936, PubMed:10564700, PubMed:11719518, PubMed:17127621), Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity), Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart, Functions via alternate outward- and inward-open conformation states, Protonation and deprotonation of 302-Asp is essential for the conformational transition (By similarity)


This is Monocarboxylate transporter 2 protein, from Golden hamster, contains 484 amino acids, is membrane-bound, locates in Cell membrane.

Proton-coupled monocarboxylate symporter (PubMed:7829520), Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate, Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity)


This is Protein SUR7 protein, from Baker's yeast, contains 302 amino acids, is membrane-bound, locates in Cell membrane.

Involved in sporulation and affects the sphingolipid composition of the plasma membrane, Probably involved in endocytosis


This is ERAD-associated E3 ubiquitin-protein ligase ASI1 protein, from Baker's yeast, contains 624 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Nucleus.

RING-type; atypical

E3 ubiquitin-protein ligase which transfers ubiquitin to substrates promoting their degradation, Part of the nuclear inner membrane (INM)-specific branch of the ER-associated degradation (ERAD) pathway, required for the elimination of misfolded proteins in the INM, a specialized ER subdomain, Required for ERG11 degradation (PubMed:25236469), Negative regulator of SPS-sensor signaling, Together with ASI2 and ASI3, prevents the unprocessed precursor forms of STP1 and STP2 that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes in the absence of inducing signals (PubMed:16735580, PubMed:17085444), Controls amino acid permease (AAP) gene expression in response to amino acid availability, a process mediated by the transcription factors STP1 and STP1 (PubMed:11454748)


This is Arginine--tRNA ligase, cytoplasmic protein, from Human, contains 660 amino acids, is soluble, locates in Cytoplasm.

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775), Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684)

Belongs to the class-I aminoacyl-tRNA synthetase family


This is Ammonium transporter 1 member 1 protein, from Mouse-ear cress, contains 501 amino acids, is membrane-bound, locates in Cell membrane.

High affinity ammonium transporter probably involved in ammonium uptake from the soil, long-distance transport to the shoots and re-uptake of apoplastic ammonium that derives from photorespiration in shoots, Contributes with AMT1-3 to the overall ammonium uptake capacity in roots under nitrogen-deficiency conditions

Belongs to the ammonia transporter channel (TC 1,A,11,2) family


This is Acetylcholine receptor subunit alpha-type deg-3 protein, from Caenorhabditis elegans, contains 564 amino acids, is membrane-bound, locates in Cell membrane.

Subunit of the non-synaptic neuronal acetylcholine receptor, which may play a role in chemotaxis towards choline, After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (PubMed:9860996, PubMed:11273652)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily


This is Ataxin-3 protein, from Human, contains 361 amino acids, is soluble, locates in Nucleus.

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278), Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782), Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity), Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501), Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460)


This is Mismatch repair endonuclease PMS2 protein, from Human, contains 862 amino acids, locates in Nucleus.

Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042), Heterodimerizes with MLH1 to form MutL alpha, DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex, Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2, It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch, DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected, MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR, Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages, Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042)

Belongs to the DNA mismatch repair MutL/HexB family


This is Inactive pancreatic lipase-related protein 1 protein, from Human, contains 467 amino acids, is soluble, locates in Extracellular.

May function as inhibitor of dietary triglyceride digestion, Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity)


This is Pancreatic lipase-related protein 2 protein, from Human, contains 469 amino acids, is soluble, locates in Extracellular.

Lipase that primarily hydrolyzes triglycerides and galactosylglycerides (PubMed:15287741, PubMed:17401110, PubMed:19451396, PubMed:21865348, PubMed:20083229, PubMed:26494624, PubMed:18702514), In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides (PubMed:23732775, PubMed:19824014, PubMed:21652702), Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity (PubMed:15287741, PubMed:17401110, PubMed:21865348, PubMed:21652702, PubMed:18702514), Can completely deacylate triacylglycerols (PubMed:21865348), When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase, Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids (PubMed:15287741, PubMed:17401110, PubMed:20083229, PubMed:26494624, PubMed:18702514), Hydrolyzes medium- and long-chain fatty acyls in galactolipids (PubMed:20083229, PubMed:18702514), May act together with LIPF to hydrolyze partially digested triglycerides (PubMed:23732775), Hydrolyzes long-chain monoglycerides with high efficiency (PubMed:17401110, PubMed:21652702, PubMed:23732775), In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity), Also has low phospholipase activity (PubMed:17401110, PubMed:18702514), In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity), The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity)


This is Vesicle-fusing ATPase 2 protein, from Fruit fly, contains 752 amino acids, is soluble, locates in Cytoplasm.

Required for vesicle-mediated transport, Catalyzes the fusion of transport vesicles within the Golgi cisternae, Is also required for transport from the endoplasmic reticulum to the Golgi stack, Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity)


This is Tyrosine--tRNA ligase, cytoplasmic protein, from Human, contains 528 amino acids, is soluble, locates in Cytoplasm.

Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949), Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity (PubMed:25533949), Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:25533949)


This is Single-stranded DNA-binding protein, mitochondrial protein, from Fruit fly, contains 146 amino acids, locates in Mitochondrion.

Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:7673145, PubMed:8206370, PubMed:21953457), Required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the gamma complex polymerase PolG1/tam at the replication fork (PubMed:21953457, PubMed:26446790, PubMed:14754882, PubMed:28318978, PubMed:7673145, PubMed:11294889), Promotes PolG1 activity largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate PolG1 activity (PubMed:26446790, PubMed:21953457, PubMed:7673145)


This is Calcium-dependent cell adhesion molecule 1 protein, from Social amoeba, contains 213 amino acids, is membrane-bound, locates in Cell membrane.

Mediates calcium-dependent cell-cell adhesion during the early stage of development


This is Protein rtoA protein, from Social amoeba, contains 367 amino acids, is soluble, locates in Cytoplasm.

May have dual functions, one in vegetative cells at starvation involving cell-type choice and a later function involving progression to the tipped mound stage, Involved in vesicle fusion in endo- and exocytosis, Involved in L,pneumophila intracellular growth


This is G1/S-specific cyclin-E protein, from Fruit fly, contains 709 amino acids, locates in Nucleus.

Essential for the control of the cell cycle at the G1/S (start) transition, Targeted by archipelago for degradation by the SFC ubiquitin ligase complex

Belongs to the cyclin family, Cyclin E subfamily


This is Ephrin type-B receptor 4 protein, from Human, contains 987 amino acids, is membrane-bound, locates in Cell membrane.

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability, EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells

Belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily