This is NAD-dependent protein deacetylase sirtuin-1 protein, from Human, contains 747 amino acids, locates in Cytoplasm.

(Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein, The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection

Belongs to the sirtuin family, Class I subfamily


This is Protein Hook homolog 2 protein, from Human, contains 719 amino acids, is soluble, locates in Cytoplasm.

Component of the FTS/Hook/FHIP complex (FHF complex), The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex), Contributes to the establishment and maintenance of centrosome function, May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones, FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997)


This is Myotubularin-related protein 8 protein, from Human, contains 704 amino acids, locates in Nucleus.

Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:22647598, PubMed:26143924), Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:22647598, PubMed:26143924), In complex with MTMR9, negatively regulates autophagy (PubMed:22647598)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is Mitochondrial assembly of ribosomal large subunit protein 1 protein, from Human, contains 234 amino acids, is soluble, locates in Mitochondrion.

Required for normal mitochondrial ribosome function and mitochondrial translation (PubMed:22238375, PubMed:23171548), May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable), Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable), Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable), May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome (PubMed:22238376, PubMed:23171548), May function as a ribosomal silencing factor (Probable)


This is KIF-binding protein protein, from Human, contains 621 amino acids, is soluble, locates in Cytoplasm.

Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development

Belongs to the KIF-binding protein family


This is Sodium/bile acid cotransporter 4 protein, from Human, contains 437 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the bile acid:sodium symporter (BASS) (TC 2,A,28) family


This is Ribosomal RNA processing protein 36 homolog protein, from Human, contains 259 amino acids, locates in Nucleus.

Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA


This is Small ribosomal subunit protein mS39 protein, from Human, contains 689 amino acids, locates in Mitochondrion.

Mitochondrial RNA-binding protein that has a role in mitochondrial translation

Belongs to the mitochondrion-specific ribosomal protein mS39 family


This is Enhancer of mRNA-decapping protein 3 protein, from Human, contains 508 amino acids, is soluble, locates in Cytoplasm.

Binds single-stranded RNA, Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping, May play a role in spermiogenesis and oogenesis


This is ATP-dependent DNA helicase DDX11 protein, from Human, contains 970 amino acids, locates in Nucleus.

(Microbial infection) Required for bovine papillomavirus type 1 regulatory protein E2 loading onto mitotic chromosomes during DNA replication for the viral genome to be maintained and segregated

Belongs to the DEAD box helicase family, DEAH subfamily, DDX11/CHL1 sub-subfamily


This is Phosphoinositide-3-kinase-interacting protein 1 protein, from Human, contains 263 amino acids, is membrane-bound, locates in Cell membrane.

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity


This is Multidrug and toxin extrusion protein 1 protein, from Human, contains 570 amino acids, is membrane-bound, locates in Cell membrane.

Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534), Plays a physiological role in the excretion of cationic compounds including endogenous metabolites, drugs, toxins through the kidney and liver, into urine and bile respectively (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373), Mediates the efflux of endogenous compounds such as creatinine, vitamin B1/thiamine, agmatine and estrone-3-sulfate (PubMed:16330770, PubMed:17495125, PubMed:17509534, PubMed:17582384, PubMed:18305230, PubMed:19158817, PubMed:21128598, PubMed:24961373), May also contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable)

Belongs to the multi antimicrobial extrusion (MATE) (TC 2,A,66,1) family


This is Intraflagellar transport protein 43 homolog protein, from Human, contains 208 amino acids, is soluble, locates in Cytoplasm.

As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis (PubMed:28400947, PubMed:28973684), Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base (PubMed:21378380)


This is Protein-lysine N-methyltransferase EEF2KMT protein, from Human, contains 330 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'

Belongs to the class I-like SAM-binding methyltransferase superfamily, EEF2KMT family


This is U3 small nucleolar ribonucleoprotein protein IMP4 protein, from Human, contains 291 amino acids, locates in Nucleus.

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP), Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)


This is Diphosphoinositol polyphosphate phosphohydrolase 3-beta protein, from Human, contains 164 amino acids, is soluble, locates in Cytoplasm.

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction, Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates, The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A, Also able to hydrolyze 5-phosphoribose 1-diphosphate

Belongs to the Nudix hydrolase family, DIPP subfamily


This is Centrosomal protein of 95 kDa protein, from Human, contains 821 amino acids, is soluble, locates in Cytoplasm.


This is Target of EGR1 protein 1 protein, from Human, contains 510 amino acids, has 1 C3H1-type Zinc finger, locates in Nucleus.

Inhibits cell growth rate and cell cycle, Induces CDKN1A expression as well as TGF-beta expression, Mediates the inhibitory growth effect of EGR1, Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684)


This is Probable ATP-dependent RNA helicase DDX27 protein, from Human, contains 796 amino acids, locates in Nucleus.

Probable ATP-dependent RNA helicase, Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154)

Belongs to the DEAD box helicase family, DDX27/DRS1 subfamily


This is Zinc transporter ZIP13 protein, from Human, contains 371 amino acids, is membrane-bound, locates in Golgi apparatus.

Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233), May regulate beige adipocyte differentiation (By similarity)

Belongs to the ZIP transporter (TC 2,A,5) family


This is Peroxisomal membrane protein 11C protein, from Human, contains 241 amino acids, is membrane-bound, locates in Peroxisome.

Promotes membrane protrusion and elongation on the peroxisomal surface


This is ERO1-like protein alpha protein, from Human, contains 468 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum, Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation, Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell, Required for the proper folding of immunoglobulins (PubMed:29858230), Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1, Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V,cholerae, thereby playing a role in retrotranslocation of the toxin


This is Sentrin-specific protease 5 protein, from Human, contains 755 amino acids, locates in Nucleus.

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins, Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates, Required for cell division


This is Receptor expression-enhancing protein 6 protein, from Human, contains 211 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Required for correct function and survival of retinal photoreceptors (PubMed:27889058), Required for retinal development (By similarity), In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity), May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity)


This is Serine/threonine-protein phosphatase PGAM5, mitochondrial protein, from Human, contains 289 amino acids, is membrane-bound, locates in Mitochondrion.

Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase, Has apparently no phosphoglycerate mutase activity, May be regulator of mitochondrial dynamics, Substrate for a KEAP1-dependent ubiquitin ligase complex, Contributes to the repression of NFE2L2-dependent gene expression, Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore

Belongs to the phosphoglycerate mutase family, BPG-dependent PGAM subfamily


This is Small G protein signaling modulator 3 protein, from Human, contains 749 amino acids, is soluble, locates in Cytoplasm.

May play a cooperative role in NF2-mediated growth suppression of cells

Belongs to the small G protein signaling modulator family


This is Probable asparagine--tRNA ligase, mitochondrial protein, from Human, contains 477 amino acids, is soluble, locates in Mitochondrion.

Belongs to the class-II aminoacyl-tRNA synthetase family


This is Mannose-1-phosphate guanyltransferase alpha protein, from Human, contains 420 amino acids, is soluble, locates in Cytoplasm.

May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose

Belongs to the transferase hexapeptide repeat family


This is Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase protein, from Human, contains 654 amino acids, is soluble, locates in Cytoplasm.

Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation, Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp, Prefers proteins containing high-mannose over those bearing complex type oligosaccharides, Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins, Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins

Belongs to the transglutaminase-like superfamily, PNGase family


This is Kinetochore-associated protein NSL1 homolog protein, from Human, contains 281 amino acids, locates in Nucleus.

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis


This is Androgen-dependent TFPI-regulating protein protein, from Human, contains 230 amino acids, is membrane-bound, locates in Cell membrane.

Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888), Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888), Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (PubMed:21868574)


This is Pleckstrin homology domain-containing family A member 8 protein, from Human, contains 519 amino acids, is membrane-bound, locates in Golgi apparatus.

Cargo transport protein that is required for apical transport from the Golgi complex, Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation, Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids, Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability, Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation


This is Conserved oligomeric Golgi complex subunit 3 protein, from Human, contains 828 amino acids, is membrane-bound, locates in Golgi apparatus.


This is MAGUK p55 subfamily member 4 protein, from Human, contains 637 amino acids, is soluble, locates in Cytoplasm.

May play a role in retinal photoreceptors development


This is Protein disulfide-isomerase TMX3 protein, from Human, contains 454 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds, May act as a dithiol oxidase

Belongs to the protein disulfide isomerase family


This is Ligand-dependent corepressor protein, from Human, contains 433 amino acids, locates in Nucleus.

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity), Repressor of ligand-dependent transcription activation by target nuclear receptors, Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR


This is E3 ubiquitin-protein ligase ZFP91 protein, from Human, contains 570 amino acids, has 5 C2H2-type Zinc finger, locates in Nucleus.

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK, It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway, May also play an important role in cell proliferation and/or anti-apoptosis

Belongs to the krueppel C2H2-type zinc-finger protein family


This is E3 ubiquitin-protein ligase RNF170 protein, from Human, contains 258 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Endoplasmic reticulum.

RING-type

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway, Also involved in ITPR1 turnover in resting cells


This is RBPJ-interacting and tubulin-associated protein 1 protein, from Human, contains 269 amino acids, locates in Cytoplasm.

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway, Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription, May play a role in neurogenesis


This is Potassium voltage-gated channel subfamily S member 1 protein, from Human, contains 526 amino acids, is membrane-bound, locates in Cell membrane.

Potassium channel subunit that does not form functional channels by itself, Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328)

Belongs to the potassium channel family, S (TC 1,A,1,2) subfamily, Kv9,1/KCNS1 sub-subfamily


This is Homeobox protein PKNOX2 protein, from Human, contains 472 amino acids, locates in Nucleus.

Belongs to the TALE/MEIS homeobox family


This is Cytosolic non-specific dipeptidase protein, from Human, contains 475 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the peptide bond hydrolysis in dipeptides, displaying a non-redundant activity toward threonyl dipeptides (By similarity), Mediates threonyl dipeptide catabolism in a tissue-specific way (By similarity), Has high dipeptidase activity toward cysteinylglycine, an intermediate metabolite in glutathione metabolism (PubMed:19346245, PubMed:12473676), Metabolizes N-lactoyl-amino acids, both through hydrolysis to form lactic acid and amino acids, as well as through their formation by reverse proteolysis (PubMed:25964343), Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568)


This is Prolyl hydroxylase EGLN2 protein, from Human, contains 407 amino acids, locates in Nucleus.

Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902), Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519), Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211), Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519), Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519), Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519), Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519), Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519), EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519), Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519), Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902), Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296), Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity)


This is Sushi domain-containing protein 3 protein, from Human, contains 255 amino acids, is membrane-bound, locates in Cell membrane.

May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration


This is Calreticulin-3 protein, from Human, contains 384 amino acids, is soluble, locates in Endoplasmic reticulum.

During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3, Required for sperm fertility (By similarity), CALR3 capacity for calcium-binding may be absent or much lower than that of CALR


This is MAP/microtubule affinity-regulating kinase 4 protein, from Human, contains 752 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942), Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762), Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945), Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532), Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999), Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999), Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532), Reduces neuronal cell survival (PubMed:15009667), Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity), Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity), Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942), Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily


This is Beta-1,3-galactosyltransferase 6 protein, from Human, contains 329 amino acids, is membrane-bound, locates in Golgi apparatus.

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue, Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate, Has no activity towards substrates with terminal glucosamine or galactosamine residues

Belongs to the glycosyltransferase 31 family


This is Fc receptor-like protein 2 protein, from Human, contains 508 amino acids, has 4 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May have an regulatory role in normal and neoplastic B cell development


This is Fc receptor-like protein 1 protein, from Human, contains 429 amino acids, has 3 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May function as an activating coreceptor in B-cells, May function in B-cells activation and differentiation


This is Protein arginine N-methyltransferase 6 protein, from Human, contains 375 amino acids, locates in Nucleus.

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910, PubMed:30420520), Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (PubMed:17898714, PubMed:18077460, PubMed:18079182, PubMed:19405910), Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (PubMed:17898714, PubMed:18079182, PubMed:18077460), H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (PubMed:17898714, PubMed:18077460), Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:19509293), Repression of TP53 blocks cellular senescence (By similarity), Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively), Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (PubMed:16600869), Methylates HMGA1 (PubMed:16157300, PubMed:16159886), Regulates alternative splicing events, Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1, Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (By similarity), May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC) (PubMed:17267505), Methylates GPS2, protecting GPS2 from ubiquitination and degradation (By similarity), Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (PubMed:30420520)

Belongs to the class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT6 subfamily


This is Peptidoglycan recognition protein 4 protein, from Human, contains 373 amino acids, is soluble, locates in Extracellular.

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria, Has bactericidal activity towards Gram-positive bacteria, May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis, Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria, Plays a role in innate immunity

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family


This is Peptidoglycan recognition protein 3 protein, from Human, contains 341 amino acids, is soluble, locates in Extracellular.


This is Centrosomal protein of 19 kDa protein, from Human, contains 163 amino acids, is soluble, locates in Cytoplasm.

Required for ciliation (PubMed:28625565, PubMed:28428259, PubMed:28659385), Recruits the RABL2B GTPase to the ciliary base to initiate ciliation, After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28625565, PubMed:28428259), Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly, Involved in microtubule (MT) anchoring to the centrosomes (PubMed:28659385)


This is Leucine rich adaptor protein 1 protein, from Human, contains 239 amino acids, is soluble, locates in Cytoplasm.

Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines, Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (PubMed:21048106), In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration, Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity)


This is Sphingomyelin synthase-related protein 1 protein, from Human, contains 415 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide, SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield, Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides, Seems to be critical for the integrity of the early secretory pathway

Belongs to the sphingomyelin synthase family


This is RNA-binding region-containing protein 3 protein, from Human, contains 517 amino acids, locates in Nucleus.

Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns, U12-type introns comprises less than 1% of all non-coding sequences, Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA


This is Adenylate kinase 8 protein, from Human, contains 479 amino acids, is soluble, locates in Cytoplasm.

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates, Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP, Also displays broad nucleoside diphosphate kinase activity


This is E3 SUMO-protein ligase NSE2 protein, from Human, contains 247 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316), Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316), The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316), The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526), Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850), Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526), SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526), Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785)


This is Protein HEXIM2 protein, from Human, contains 286 amino acids, locates in Nucleus.

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662), Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662)


This is Cilia- and flagella-associated protein 418 protein, from Human, contains 207 amino acids, is soluble, locates in Cytoplasm.

May be involved in photoreceptor outer segment disk morphogenesis (By similarity)


This is Apoptosis-inducing factor 3 protein, from Human, contains 605 amino acids, locates in Mitochondrion.

Induces apoptosis through a caspase dependent pathway, Reduces mitochondrial membrane potential

Belongs to the FAD-dependent oxidoreductase family


This is Patched domain-containing protein 1 protein, from Human, contains 888 amino acids, is membrane-bound, locates in Cell membrane.

Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention


This is Proline-rich acidic protein 1 protein, from Human, contains 151 amino acids, is soluble, locates in Extracellular.

Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity), Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity), May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459), Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459), May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861)


This is Fc receptor-like protein 3 protein, from Human, contains 734 amino acids, has 6 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation, Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366), Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases, Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936), Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:20190142, PubMed:19494275), Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion (PubMed:36070373), Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion (PubMed:36070373)


This is Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 protein, from Human, contains 875 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

GTPase-activating protein for the ADP ribosylation factor family (Potential), GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway

Belongs to the centaurin gamma-like family


This is N-terminal EF-hand calcium-binding protein 3 protein, from Human, contains 396 amino acids, locates in Golgi apparatus.

Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta, May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3


This is Inositol hexakisphosphate kinase 3 protein, from Human, contains 410 amino acids, is soluble, locates in Cytoplasm.

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5), Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

Belongs to the inositol phosphokinase (IPK) family


This is Testis-specific serine/threonine-protein kinase 2 protein, from Human, contains 358 amino acids, is soluble, locates in Cytoplasm.

Testis-specific serine/threonine-protein kinase required during spermatid development, Phosphorylates TSKS at 'Ser-288' and SPAG16, Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm, During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family


This is Bcl-2-binding component 3, isoforms 3/4 protein, from Human, contains 261 amino acids, locates in Mitochondrion.


This is Fc receptor-like protein 4 protein, from Human, contains 515 amino acids, has 4 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May function as an inhibitor of the B-cell receptor signaling, May function in the B-cell-mediated immune response


This is E3 ubiquitin-protein ligase UHRF2 protein, from Human, contains 802 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger, locates in Nucleus.

PHD-type

RING-type

E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:29506131, PubMed:27743347, PubMed:23404503), Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:27129234, PubMed:24813944), This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity), Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639), Ubiquitinates also PCNP leading to its degradation by the proteasome (PubMed:14741369, PubMed:12176013), Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteasomal degradation (PubMed:29923055), Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor, Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751), Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395)


This is Protein FAM193B protein, from Human, contains 902 amino acids, locates in Cytoplasm.


This is Derlin-3 protein, from Human, contains 235 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins, May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome, May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976), May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908)


This is Serine/threonine-protein phosphatase 1 regulatory subunit 10 protein, from Human, contains 940 amino acids, has 1 C3H1-type Zinc finger, locates in Nucleus.

Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex, The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase, Mediates interaction of WDR82 and PPP1CA, Inhibitor of PPP1CA and PPP1CC phosphatase activities, Has inhibitory activity on PPP1CA only when phosphorylated, Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity)


This is Sodium-coupled neutral amino acid symporter 2 protein, from Human, contains 506 amino acids, is membrane-bound, locates in Cell membrane.

Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15922329, PubMed:16621798, PubMed:15774260), The trasnport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1, May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260), May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity), Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity), Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity)

Belongs to the amino acid/polyamine transporter 2 family


This is UAP56-interacting factor protein, from Human, contains 318 amino acids, is soluble, locates in Nucleus.

Required for mRNA export from the nucleus to the cytoplasm, Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore, Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4


This is Transcription elongation factor, mitochondrial protein, from Human, contains 360 amino acids, is soluble, locates in Mitochondrion.

Transcription elongation factor which increases mitochondrial RNA polymerase processivity, Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery


This is Transcriptional activator protein Pur-beta protein, from Human, contains 312 amino acids, locates in Nucleus.

Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene, Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts, Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element, Modulates constitutive liver galectin-3 gene transcription by binding to its promoter, May play a role in the dendritic transport of a subset of mRNAs (By similarity)

Belongs to the PUR DNA-binding protein family


This is Fc receptor-like protein 5 protein, from Human, contains 977 amino acids, has 8 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

Ig-like C2-type

May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages, May have an immunoregulatory role in marginal zone B-cells, May play a role in fertilization (By similarity)


This is Zinc finger protein 300 protein, from Human, contains 604 amino acids, has 12 C2H2-type Zinc finger, locates in Nucleus.

Has a transcriptional repressor activity


This is Bile acid receptor protein, from Human, contains 486 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is BRCA1-A complex subunit RAP80 protein, from Human, contains 719 amino acids, has 1 UBZ4-type Zinc finger, locates in Nucleus.

Ubiquitin-binding protein (PubMed:24627472), Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref,38), Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs), The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin, May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo, Does not bind Lys-48'-linked ubiquitin, May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1


This is Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial protein, from Human, contains 725 amino acids, is soluble, locates in Mitochondrion.

Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism


This is Twinkle mtDNA helicase protein, from Human, contains 684 amino acids, is soluble, locates in Mitochondrion.

Lack DNA unwinding and ATP hydrolysis activities (PubMed:18039713), Does not bind single-stranded or double-stranded DNA (PubMed:18039713)


This is Tribbles homolog 3 protein, from Human, contains 358 amino acids, locates in Nucleus.

Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15781252, PubMed:15775988), Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (PubMed:15781252, PubMed:15775988), May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (PubMed:15781252, PubMed:15775988), Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity), Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity), May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity), Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity (PubMed:12736262), Interacts with MAPK kinases and regulates activation of MAP kinases (PubMed:15299019), Can inhibit APOBEC3A editing of nuclear DNA (PubMed:22977230)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, Tribbles subfamily


This is Lipase maturation factor 1 protein, from Human, contains 567 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the maturation of specific proteins in the endoplasmic reticulum, Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway, Each LMF1 molecule chaperones 50 or more molecules of LPL

Belongs to the lipase maturation factor family


This is EKC/KEOPS complex subunit TP53RK protein, from Human, contains 253 amino acids, locates in Nucleus.

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914), The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914), TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity), Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806)

Belongs to the protein kinase superfamily, BUD32 family


This is GPI transamidase component PIG-S protein, from Human, contains 555 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the GPI transamidase complex, Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates


This is Dual specificity testis-specific protein kinase 2 protein, from Human, contains 571 amino acids, locates in Nucleus.

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues, Phosphorylates cofilin at 'Ser-3', May play an important role in spermatogenesis

Belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family


This is Protein artemis protein, from Human, contains 692 amino acids, locates in Nucleus.

Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993), Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996), V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996), These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996), These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996), This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:15071507, PubMed:15574326, PubMed:11955432, PubMed:15936993), The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432), Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628)

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family


This is Solute carrier family 49 member 4 protein, from Human, contains 478 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Belongs to the major facilitator superfamily


This is Cytochrome P450 2S1 protein, from Human, contains 504 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195), In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid, For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469), Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195), Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195)


This is Protein IWS1 homolog protein, from Human, contains 819 amino acids, locates in Nucleus.

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts, Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A), The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription


This is Bifunctional polynucleotide phosphatase/kinase protein, from Human, contains 521 amino acids, locates in Nucleus.

Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways (PubMed:10446192, PubMed:10446193, PubMed:15385968, PubMed:20852255, PubMed:28453785), Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone (PubMed:10446192, PubMed:10446193)

In the N-terminal section; belongs to the DNA 3' phosphatase family


This is Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 protein, from Human, contains 252 amino acids, locates in Mitochondrion.

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP, Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency, Can use triazofurin monophosphate (TrMP) as substrate, Can also use GTP and ITP as nucleotide donors, Also catalyzes the reverse reaction, i,e, the pyrophosphorolytic cleavage of NAD(+), For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates, Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+), Protects against axonal degeneration following injury

Belongs to the eukaryotic NMN adenylyltransferase family


This is Histone-lysine N-methyltransferase SETDB2 protein, from Human, contains 719 amino acids, locates in Nucleus.

Histone methyltransferase involved in left-right axis specification in early development and mitosis, Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3), H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones, Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats, Plays a role in chromosome condensation and segregation during mitosis

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is E3 ubiquitin-protein ligase UHRF1 protein, from Human, contains 793 amino acids, has 1 PHD-type Zinc finger, has 1 RING-type Zinc finger, locates in Nucleus.

PHD-type

RING-type

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification, Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication, In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins, Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication, Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications, Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML, It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo, Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation


This is DNA-binding protein rap1 protein, from Fission yeast, contains 693 amino acids, locates in Nucleus.

Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE), Unlike yeast, exhibits no effect in transcription regulation


This is Thyroid hormone receptor alpha-A protein, from Zebrafish, contains 427 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

High affinity receptor for triiodothyronine (By similarity), In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor, Whereas in the presence of thyroid hormone, can act as an activator of transcription, In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development


This is Embryonic polyadenylate-binding protein A protein, from African clawed frog, contains 629 amino acids, is soluble, locates in Cytoplasm.

Binds and protects the poly(A) tail of mRNA with or without an AU-rich element (ARE) and prevents mRNA deadenylation, Stimulates the translation of mRNAs to which it is bound during early development

Belongs to the polyadenylate-binding protein type-1 family


This is Very-long-chain enoyl-CoA reductase protein, from Baker's yeast, contains 310 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle, This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle, This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation, Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators, VLCFAs serve for instance as precursors for ceramide and sphingolipids, Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress

Belongs to the steroid 5-alpha reductase family


This is Nucleolar complex protein 14 protein, from Baker's yeast, contains 810 amino acids, locates in Nucleus.

Involved in nucleolar processing of pre-18S ribosomal RNA, Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm


This is Protein OS-9 homolog protein, from Baker's yeast, contains 542 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Lectin involved in the quality control of the secretory pathway, As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation, The recognition of targets is N-glycan specific, Functions in recruiting misfolded protein substrates in conjunction with HRD3 (PubMed:32327568)


This is Mediator of RNA polymerase II transcription subunit 11 protein, from Baker's yeast, contains 115 amino acids, locates in Nucleus.

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex (PIC) with RNA polymerase II and the general transcription factors, The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II, The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins, The essential MED11/22 heterodimer specifically functions in promoting stable PIC formation

Belongs to the mediator complex subunit 11 family


This is Protein SEY1 protein, from Baker's yeast, contains 776 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network, Has GTPase activity, which is required for its function in ER organization

Belongs to the TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3 GTPase family, RHD3 subfamily


This is Something about silencing protein 5 protein, from Baker's yeast, contains 248 amino acids, locates in Nucleus.

Component of the SAS complex, a multiprotein complex that acetylates 'Lys-16' of histone H4 and 'Lys-14' of histone H3, The SAS complex is however unable to acetylate nucleosomal histones, The complex is involved in transcriptional silencing at telomeres and at HML locus, Also involved in rDNA silencing, In the complex, SAS5 is required for maximal histone acetyltransferase (HAT) activity of the complex, suggesting that it may be required to stabilize the complex or help in substrate recognition


This is Vacuolar calcium ion transporter protein, from Baker's yeast, contains 411 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane, Involved also in manganese ion homeostasis via its uptake into the vacuole

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2,A,19) family


This is Tubulin-folding cofactor B protein, from Human, contains 244 amino acids, is soluble, locates in Cytoplasm.

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649), Involved in regulation of tubulin heterodimer dissociation, May function as a negative regulator of axonal growth (By similarity)


This is E3 ubiquitin-protein ligase RING2 protein, from Human, contains 336 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:33864376, PubMed:21772249, PubMed:25355358, PubMed:26151332), H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals, May be involved in the initiation of both imprinted and random X inactivation (By similarity), Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332), PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332), E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249), Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable), Association with the chromosomal DNA is cell-cycle dependent, In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity), Also acts as a negative regulator of autophagy by mediating ubiquitination of AMBRA1, leading to its subsequent degradation (By similarity)


This is P2X purinoceptor 7 protein, from Human, contains 595 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for ATP that acts as a ligand-gated ion channel, Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules, Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells, In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206)


This is Protein FEV protein, from Human, contains 238 amino acids, locates in Nucleus.

Functions as a transcriptional regulator, According to PubMed:12761502, it functions as a transcriptional repressor, Functions in the differentiation and the maintenance of the central serotonergic neurons, May play a role in cell growth


This is ETS-related transcription factor Elf-4 protein, from Human, contains 663 amino acids, locates in Nucleus.

Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3', Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene, Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity), Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells (PubMed:34326534), Plays a role in the development and function of NK and NK T-cells and in innate immunity, Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity), Controls cell senescence in a p53-dependent manner, Can also promote cellular transformation through inhibition of the p16 pathway, Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses, Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071), Is a negative regulator of pro-inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071), Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (By similarity) (PubMed:34326534, PubMed:35266071)


This is Protein C10 protein, from Human, contains 126 amino acids, is soluble, locates in Cytoplasm.

In brain, may be required for corpus callosum development


This is Cell growth regulator with RING finger domain protein 1 protein, from Human, contains 332 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Able to inhibit growth in several cell lines


This is Zinc finger protein Gfi-1 protein, from Human, contains 422 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Transcription repressor essential for hematopoiesis, Functions in a cell-context and development-specific manner, Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes, Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development, Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development, Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity), Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling, Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA, Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth, Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters, Required for the maintenance of inner ear hair cells


This is DNA endonuclease RBBP8 protein, from Human, contains 897 amino acids, locates in Nucleus.

Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway (PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:26721387), HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse (PubMed:17965729, PubMed:19202191), Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ) (PubMed:19202191), Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA (PubMed:16581787, PubMed:17965729, PubMed:19759395, PubMed:20064462), Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:15485915, PubMed:16818604), During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity)


This is Neuronal PAS domain-containing protein 2 protein, from Human, contains 824 amino acids, locates in Nucleus.

Transcriptional activator which forms a core component of the circadian clock, The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior, It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function, Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system, Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'), The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN, The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle, Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day, Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle), A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively, Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging, A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism, Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters, The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression, This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively, The NPAS2-BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina, NPAS2 plays an important role in sleep homeostasis and in maintaining circadian behaviors in normal light/dark and feeding conditions and in the effective synchronization of feeding behavior with scheduled food availability, Regulates the gene transcription of key metabolic pathways in the liver and is involved in DNA damage response by regulating several cell cycle and DNA repair genes, Controls the circadian rhythm of NR0B2 expression by binding rhythmically to its promoter (By similarity), Mediates the diurnal variation in the expression of GABARA1 receptor in the brain and contributes to the regulation of anxiety-like behaviors and GABAergic neurotransmission in the ventral striatum (By similarity)


This is Thioredoxin, mitochondrial protein, from Human, contains 166 amino acids, locates in Mitochondrion.

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability, Possesses a dithiol-reducing activity


This is Homeobox protein Nkx-3.1 protein, from Human, contains 234 amino acids, locates in Nucleus.

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor, Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate, Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells


This is Myeloid differentiation primary response protein MyD88 protein, from Human, contains 296 amino acids, is soluble, locates in Cytoplasm.

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825), Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249), Increases IL-8 transcription (PubMed:9013863), Involved in IL-18-mediated signaling pathway, Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes, Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825), MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity)


This is Probable rRNA-processing protein EBP2 protein, from Human, contains 306 amino acids, locates in Nucleus.

Required for the processing of the 27S pre-rRNA


This is AT-rich interactive domain-containing protein 3A protein, from Human, contains 593 amino acids, locates in Cytoplasm.

Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation


This is Achaete-scute homolog 2 protein, from Human, contains 193 amino acids, locates in Nucleus.

Transcription factor, Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3, May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes, Required during post-implantation development for the generation of some differentiated trophoblast cell types, Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins, Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6, May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation, Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin, May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (By similarity), Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells, May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (By similarity), May be dispensable for blastocyst formation and later embryonic function (By similarity), May be involved in the determination of neuronal precursors (By similarity)


This is Opiorphin prepropeptide protein, from Human, contains 248 amino acids, is soluble, locates in Extracellular.

Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N, Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively, Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM, Has a potent analgesic effect when administered to rats by intravenous injection


This is 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha protein, from Human, contains 283 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is Forkhead box protein C2 protein, from Human, contains 501 amino acids, locates in Nucleus.

Transcriptional activator, Might be involved in the formation of special mesenchymal tissues


This is Cbp/p300-interacting transactivator 1 protein, from Human, contains 193 amino acids, locates in Cytoplasm.

Transcriptional coactivator of the p300/CBP-mediated transcription complex, Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex, Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300, Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex, Induces transcription from estrogen-responsive promoters and protection against cell death, Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter, Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling, May play a role in pigmentation of melanocytes, Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner


This is Cbp/p300-interacting transactivator 2 protein, from Human, contains 270 amino acids, locates in Nucleus.

Transcriptional coactivator of the p300/CBP-mediated transcription complex, Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation, Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex, Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity, Enhances estrogen-dependent transactivation mediated by estrogen receptors, Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex, Participates in sex determination and early gonad development by stimulating transcription activation of SRY, Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM), Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity, Associates with chromatin to the PITX2 P1 promoter region


This is DNA dC->dU-editing enzyme APOBEC-3 protein, from Mouse, contains 440 amino acids, is soluble, locates in Cytoplasm.

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms, Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA, Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons

Belongs to the cytidine and deoxycytidylate deaminase family


This is DNA damage-binding protein 2 protein, from Mouse, contains 432 amino acids, locates in Nucleus.

Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (PubMed:12107171), Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (PubMed:33937266), The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity), Also functions as the substrate recognition module for the DCX (DDB2-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB2-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) (By similarity), The DDB2-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage (By similarity), The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity), The DDB2-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity), The DDB2-CUL4-ROC1 complex also ubiquitinates KAT7/HBO1 in response to DNA damage, leading to its degradation: recognizes KAT7/HBO1 following phosphorylation by ATR (By similarity)

Belongs to the WD repeat DDB2/WDR76 family


This is Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 protein, from Mouse, contains 245 amino acids, locates in Mitochondrion.

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP, Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency, Can use triazofurin monophosphate (TrMP) as substrate, Can also use GTP and ITP as nucleotide donors, Also catalyzes the reverse reaction, i,e, the pyrophosphorolytic cleavage of NAD(+), For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates, Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity), Protects against axonal degeneration following injury


This is GTPase IMAP family member 4 protein, from Mouse, contains 328 amino acids, is soluble, locates in Cytoplasm.

During thymocyte development, may play a role in the regulation of apoptosis

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily


This is DnaJ homolog subfamily B member 11 protein, from Mouse, contains 358 amino acids, is soluble, locates in Endoplasmic reticulum.

As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins, Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed, May help recruiting HSPA5 and other chaperones to the substrate, Stimulates HSPA5 ATPase activity, It is necessary for maturation and correct trafficking of PKD1


This is PAXIP1-associated glutamate-rich protein 1A protein, from Mouse, contains 253 amino acids, locates in Nucleus.

Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation, However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex, Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460), However, its function in DNA damage has been questioned (PubMed:26744420), During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (PubMed:26744420), Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity), Acts as transcriptional cofactor for nuclear hormone receptors, Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity), May be involved in the regulation of the BMP pathway in extraembryonic development (PubMed:24633704)


This is Phosphatidylserine synthase 1 protein, from Mouse, contains 473 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:9516423, PubMed:18343815, PubMed:10938271), Catalyzes mainly the conversion of phosphatidylcholine (PubMed:9516423, PubMed:18343815, PubMed:10432300, PubMed:10938271), Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:10432300, PubMed:9516423, PubMed:18343815, PubMed:10938271)

Belongs to the phosphatidyl serine synthase family


This is Lysophosphatidylserine lipase ABHD12 protein, from Mouse, contains 398 amino acids, is membrane-bound, locates in Mitochondrion.

Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (PubMed:23297193, PubMed:25580854, PubMed:30420694), Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (PubMed:23297193), Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal (PubMed:30643283), Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways (PubMed:18096503), Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (PubMed:30237167)


This is Lipoyl synthase, mitochondrial protein, from Mouse, contains 373 amino acids, locates in Mitochondrion.

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives

Belongs to the radical SAM superfamily, Lipoyl synthase family


This is Actin-like protein 6B protein, from Mouse, contains 426 amino acids, locates in Nucleus.

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology), Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner, Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth, During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state, The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes, As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF), The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells, The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth, ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth, Essential for neuronal maturation and dendrite development (By similarity)


This is LIM and SH3 domain protein 1 protein, from Rat, contains 263 amino acids, is soluble, locates in Cytoplasm.

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities, Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types


This is Histone deacetylase 9 protein, from Mouse, contains 588 amino acids, locates in Nucleus.

Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3, Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events, Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development, Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter

Belongs to the histone deacetylase family, HD type 2 subfamily


This is Carotenoid-cleaving dioxygenase, mitochondrial protein, from Mouse, contains 532 amino acids, locates in Mitochondrion.

Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids (PubMed:11278918, PubMed:21106934), Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond (PubMed:11278918, PubMed:21106934), Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules (PubMed:21106934)

Belongs to the carotenoid oxygenase family


This is Arylacetamide deacetylase protein, from Mouse, contains 398 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity), Displays serine esterase activity in liver, Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity

Belongs to the 'GDXG' lipolytic enzyme family


This is Reticulon-4 receptor protein, from Mouse, contains 473 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for RTN4, OMG and MAG (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:18411262, PubMed:22923615), Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262), Besides, functions as receptor for chondroitin sulfate proteoglycans (PubMed:22406547), Can also bind heparin (PubMed:22406547), Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity), Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200), Mediates axonal growth inhibition (By similarity), Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:22923615), Plays a role in postnatal brain development (PubMed:27339102), Required for normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102), Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717), Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development (PubMed:20093372), Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200)


This is Acyl-CoA desaturase 3 protein, from Mouse, contains 359 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates, Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA (PubMed:16443825, PubMed:26098370), Has a strong preference for saturated fatty acids with chain lengths of 14 or 16 carbon atoms (C14:0 and C16:0), and has only very low activity with stearatate (C18:0) (PubMed:16443825, PubMed:26098370), Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)

Belongs to the fatty acid desaturase type 1 family


This is Histidine-rich glycoprotein protein, from Rat, contains 525 amino acids, is soluble, locates in Extracellular.

Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions, Inhibits rosette formation, Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis, Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway, This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions, Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes, Tethers plasminogen to the cell surface, Binds T-cells and alters the cell morphology, Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity)


This is Rho GDP-dissociation inhibitor 1 protein, from Mouse, contains 204 amino acids, is soluble, locates in Cytoplasm.

Controls Rho proteins homeostasis, Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them, Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation, Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms, Through the modulation of Rho proteins, may play a role in cell motility regulation, In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1


This is INO80 complex subunit B protein, from Mouse, contains 375 amino acids, has 1 HIT-type Zinc finger, locates in Nucleus.

HIT-type

Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair