This is NADPH-dependent codeinone reductase 1-3 protein, from Opium poppy, contains 321 amino acids, is soluble, locates in Cytoplasm.

NADPH-dependent codeinone reductase involved in biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids natural products (PubMed:10417697, PubMed:29779229, PubMed:15543134), Reduces codeinone to codeine in the penultimate step in morphine biosynthesis (PubMed:10417697, PubMed:15543134, PubMed:22098111), Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor (PubMed:10417697), Converts morphinone to morphine, and neomorphinone to neomorphine (PubMed:29779229), Reduces irreversibly neopinone, a spontaneous isomer of codeinone, to neopine; in planta, neopine levels are limited to low levels (PubMed:29779229)


This is NADPH-dependent codeinone reductase 1-2 protein, from Opium poppy, contains 321 amino acids, is soluble, locates in Cytoplasm.

NADPH-dependent codeinone reductase involved in biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids natural products (PubMed:10417697, PubMed:29779229, PubMed:15543134), Reduces codeinone to codeine in the penultimate step in morphine biosynthesis (PubMed:10417697, PubMed:29779229, PubMed:15543134, PubMed:22098111), Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor (PubMed:10417697), Converts morphinone to morphine, and neomorphinone to neomorphine (By similarity), Reduces irreversibly neopinone, a spontaneous isomer of codeinone, to neopine; in planta, neopine levels are limited to low levels (PubMed:29779229)

Belongs to the aldo/keto reductase family


This is NADPH-dependent codeinone reductase 1-1 protein, from Opium poppy, contains 321 amino acids, is soluble, locates in Cytoplasm.

NADPH-dependent reductase involved in biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids natural products (PubMed:10417697, PubMed:29779229, PubMed:15543134, PubMed:17207254), Reduces codeinone to codeine in the penultimate step in morphine biosynthesis (PubMed:10417697, PubMed:29779229, PubMed:15543134, PubMed:22098111), Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor (PubMed:10417697), Converts morphinone to morphine, and neomorphinone to neomorphine (By similarity), Reduces irreversibly neopinone, a spontaneous isomer of codeinone, to neopine; in planta, neopine levels are limited to low levels (PubMed:29779229)


This is Auxin efflux carrier component 6 protein, from Mouse-ear cress, contains 570 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the intracellular auxin-transport pathway (PubMed:19506555), Regulates auxin transport and auxin homeostasis (PubMed:23922907), Directly involved in the regulation of nectar production (PubMed:23551385), Involved in unfolded protein response (UPR) activation (PubMed:24180465), Involved in the control of vein patterning (PubMed:23437008, PubMed:24304505), Redundantly with PIN8, inhibits the vein-formation-promoting functions of PIN5 (PubMed:26560462), PIN5, PIN6, and PIN8 control vein network geometry, but they are expressed in mutually exclusive domains of leaf vascular cells (PubMed:26560462)

Belongs to the auxin efflux carrier (TC 2,A,69,1) family


This is Dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic protein, from Mouse-ear cress, contains 480 amino acids, is soluble, locates in Plastid.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)

Belongs to the 2-oxoacid dehydrogenase family


This is Protein CLP1 homolog protein, from Mouse-ear cress, contains 444 amino acids, locates in Nucleus.

Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation (By similarity), Functions in gametophyte, embryo and postembryotic development (PubMed:18971429)

Belongs to the Clp1 family, Clp1 subfamily


This is Beta-glucosidase 23 protein, from Mouse-ear cress, contains 524 amino acids, is soluble, locates in Endoplasmic reticulum.

Beta-D-glucosidase active on scopolin > esculin >> 4-MU-glucoside >> DIMBOA-glucoside, No activity with pNP-glucoside, oNP-glucoside and sinigrin as substrates, May possess beta-D-fucosidase activity, Required for the beneficial interaction with the endophytic fungus P,indica, May participate in the control of root colonization by P,indica by repressing defense responses and modulating other responses required for a mutualistic interaction

Belongs to the glycosyl hydrolase 1 family


This is Phosphoglucan phosphatase LSF2, chloroplastic protein, from Mouse-ear cress, contains 282 amino acids, locates in Plastid.

Starch-associated phosphoglucan phosphatase that selectively dephosphorylates the glucan C3 position, Probably participates in the regulation of starch degradation


This is Cytochrome P450 89A9 protein, from Mouse-ear cress, contains 511 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the chlorophyll breakdown by its action in nonpolar primary fluorescent chlorophyll catabolite (pFCC) decarbonylation (Ref,6, PubMed:23723324), Involved in the formation of major chlorophyll breakdown products, including non-fluorescent dioxobilin-type chlorophyll catabolites (NDCCs), during leaf senescence (PubMed:23723324)


This is 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2 protein, from Mouse-ear cress, contains 765 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation

Belongs to the vitamin-B12 independent methionine synthase family


This is Adenylyl-sulfate kinase 3 protein, from Mouse-ear cress, contains 208 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the synthesis of activated sulfate for the sulfation of secondary metabolites, including the glucosinolates (PubMed:19304933), Essential for plant reproduction and viability (PubMed:19903478)


This is E3 ubiquitin-protein ligase NLA protein, from Mouse-ear cress, contains 335 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination (PubMed:17355433), Plays a role in salicylic acid-mediated negative feedback regulation of salicylic acid (SA) accumulation (PubMed:18753285), May be involved in the overall regulation of SA, benzoic acid and phenylpropanoid biosynthesis (PubMed:18753285), Involved in defense response (PubMed:35839945), May act as negative regulator of resistance to the necrotrophic fungal pathogen Plectosphaerella cucumerina by modulating the accumulation of the phytoalexin camalexin and the salicylic acid- and jasmonate- dependent defense pathways (PubMed:35839945), Controls the adaptability to nitrogen limitation by channeling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis (PubMed:17355433, PubMed:18552353), Involved in the regulation of inorganic phosphate (Pi) homeostasis in a nitrate-dependent fashion (PubMed:21455488), Directs the ubiquitination and subsequent degradation of the plasma membrane-localized inorganic phosphate transporters PHT1-1 and PHT1-4, to maintain phosphate homeostasis (PubMed:24122828), The ubiquitination of PHTs triggers their clathrin-dependent endocytosis and trafficking to the vacuole through the endosomal pathway for degradation (PubMed:24122828), Functions cooperatively with UBC24/PHO2 to regulate the abundance of PHT1-1, PHT1-2 and PHT1-3 in different subcellular compartments (PubMed:24122828), Regulates Pi homeostasis by mediating, cooperatively with UBC24/PHO2, polyubiquitination of PHT1-4 and its targeting for degradation (PubMed:24474629), Directs the polyubiquitination and subsequent degradation of the plasma membrane-localized nitrate transporter NPF2,13/NRT1,7, to help plants to adapt to nitrogen deficiency by regulating the source-to-sink remobilization of nitrate (PubMed:28032637), Regulates leaf senescence during nitrogen deficiency by mediating, cooperatively with UBC24/PHO2, polyubiquitination of NAC92/ORE1 and its targeting for degradation (PubMed:30374089)


This is Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial protein, from Mouse-ear cress, contains 629 amino acids, is membrane-bound, locates in Mitochondrion.

Required for glycerol catabolism and involved in NADH/NAD(+) homeostasis (PubMed:12586344, PubMed:18599644), Essential for postgerminative growth and seedling establishment (PubMed:18599644)

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family


This is Zinc finger protein AZF2 protein, from Mouse-ear cress, contains 273 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor involved in the inhibition of plant growth under abiotic stress conditions, Can repress the expression of various genes, including osmotic stress and abscisic acid-repressive genes and auxin-inducible genes, by binding to their promoter regions in a DNA sequence-specific manner, Acts as a negative regulator of abscisic acid (ABA) signaling during seed germination, Probably involved in jasmonate (JA) early signaling response, May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade, May act as a positive regulator of leaf senescence, Has been identified as a suppressor of the deficiency of yeast snf4 mutant to grow on non-fermentable carbon source


This is Protein TOC75-3, chloroplastic protein, from Mouse-ear cress, contains 818 amino acids, is membrane-bound, locates in Plastid.

Essential protein, Mediates the insertion of proteins targeted to the outer membrane of chloroplasts (By similarity), Required for the import of protein precursors into chloroplasts, Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane


This is Protein PLASTID TRANSCRIPTIONALLY ACTIVE 16, chloroplastic protein, from Mouse-ear cress, contains 510 amino acids, is membrane-bound, locates in Plastid.

Probably involved in the regulation of plastid gene expression

Belongs to the NAD(P)-dependent epimerase/dehydratase family


This is Amidophosphoribosyltransferase 2, chloroplastic protein, from Mouse-ear cress, contains 561 amino acids, is soluble, locates in Plastid.

Catalyzes the first committed step of 'de novo purine biosynthesis from glutamine, Required for chloroplast biogenesis and cell division, Confers sensitivity to the phenyltriazole acetic acid compound [5-(4-chlorophenyl)-1-isopropyl-1H-[1,2,4]triazol-3-yl]-acetic acid (DAS734), a bleaching herbicide

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family


This is Chloroplastic lipocalin protein, from Mouse-ear cress, contains 353 amino acids, locates in Plastid.

Lipocalin that prevents thylakoidal membrane lipids peroxidation and confers protection against oxidative stress, especially mediated by singlet oxygen in response to high light and other stress (e,g, heat shocks) (PubMed:19674405, PubMed:23837879), Required for seed longevity by ensuring polyunsaturated lipids integrity (PubMed:23837879)

Belongs to the calycin superfamily, Lipocalin family


This is Heat shock 70 kDa protein 6, chloroplastic protein, from Mouse-ear cress, contains 718 amino acids, is soluble, locates in Plastid.

In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions

Belongs to the heat shock protein 70 (TC 1,A,33) family, DnaK subfamily


This is F-box protein GID2 protein, from Mouse-ear cress, contains 151 amino acids, locates in Nucleus.

Essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway, Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to activate the pathway


This is Peroxisomal membrane protein 11B protein, from Mouse-ear cress, contains 227 amino acids, is membrane-bound, locates in Peroxisome.

Involved in peroxisomal proliferation, Promotes peroxisomal duplication, aggregation or elongation without fission


This is Riboflavin biosynthesis protein PYRR, chloroplastic protein, from Mouse-ear cress, contains 599 amino acids, locates in Plastid.

Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products, Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do, Helps maintain flavin levels, Has no activity against GTP, nucleoside monophosphates or ADP-ribose

In the C-terminal section; belongs to the YbiA family


This is E3 ubiquitin-protein ligase UPL5 protein, from Mouse-ear cress, contains 873 amino acids, is soluble, locates in Cytoplasm.

E3 ubiquitin protein ligase that regulates leaf senescence through ubiquitination and subsequent degradation of WRKY53


This is Probable WRKY transcription factor 53 protein, from Mouse-ear cress, contains 324 amino acids, locates in Nucleus.

Transcription factor, Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:20409006), May regulate the early events of leaf senescence (PubMed:17369373, PubMed:20409006), Negatively regulates the expression of ESR/ESP (PubMed:20409006), Together with WRKY46 and WRKY70, promotes resistance to P,syringae, probably by enhancing salicylic acid (SA)- dependent genes, Contributes to the suppression of jasmonic acid (MeJA)-induced expression of PDF1,2 (PubMed:22325892)


This is Reticulon-like protein B2 protein, from Mouse-ear cress, contains 271 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a role in the Agrobacterium-mediated plant transformation via its interaction with VirB2, the major component of the T-pilus


This is Adenine phosphoribosyltransferase 3 protein, from Mouse-ear cress, contains 183 amino acids, is soluble, locates in Cytoplasm.

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis, May contribute to the recycling of adenine into adenylate nucleotides and the inactivation of cytokinins by phosphoribosylation, Possesses low activity toward adenine and cytokinins

Belongs to the purine/pyrimidine phosphoribosyltransferase family


This is Probable aquaporin NIP5-1 protein, from Mouse-ear cress, contains 304 amino acids, is membrane-bound, locates in Cell membrane.

Boric acid transporter, Low water transport activity, Plays an important role as plasma membrane boric acid channel for the boron uptake required for plant growth and development under boron limitation

Belongs to the MIP/aquaporin (TC 1,A,8) family, NIP (TC 1,A,8,12) subfamily


This is E3 ubiquitin-protein ligase PUB22 protein, from Mouse-ear cress, contains 435 amino acids, is soluble, locates in Cytoplasm.

E3 ubiquitin-protein ligase that negatively regulates water stress response, May control in coordination with PUB23 a drought signaling pathway by ubiquitinating cytosolic RPN12a, Acts as negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB23 and PUB24, Regulates EXO70B2 ubiquitination and degradation via the 26S proteasome to attenuate PAMP-induced signaling (PubMed:23170036)


This is Glycine-rich RNA-binding protein 2, mitochondrial protein, from Mouse-ear cress, contains 158 amino acids, locates in Mitochondrion.

Promotes the cis-splicing and editing of several mitochondrial RNAs (including NAD5 transcripts) (PubMed:28549172), Plays a role in RNA transcription or processing during stress, Binds RNAs and DNAs sequence with a preference to single-stranded nucleic acids, Displays strong affinity to poly(U) sequence, Exerts cold and freezing tolerance, probably by exhibiting an RNA chaperone activity during the cold and freezing adaptation process, Mediates cell-to-cell trafficking of RNA interference (RNAi) signals (small RNAs (sRNA), e,g, small interfering RNA (siRNA) and microRNA (miRNA)) which regulate growth and development, as well as responses to environmental inputs, including pathogen attack; can compromise zucchini yellow mosaic virus (ZYMV) and tobacco rattle virus (TRV) infections at the early stage (PubMed:31812689)


This is Zinc finger protein WIP2 protein, from Mouse-ear cress, contains 383 amino acids, has 1 C2H2-type Zinc finger, has 1 C2H2-type 2; atypical Zinc finger, has 1 C2H2-type 3; atypical Zinc finger, has 1 C2H2-type 4; atypical Zinc finger, locates in Nucleus.

C2H2-type 2; atypical

C2H2-type 3; atypical

C2H2-type 4; atypical

Transcriptional regulator required for normal differentiation of the ovary transmitting tract cells and pollen tube growth, In Arabidopsis, the transmitting tract facilitates the transport of pollen tubes to the ovules for fertilization (PubMed:17600712), May play a role in the regulation of AGL8/FUL, which is required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique (PubMed:23515580), Plays a role in replum development by the activation of the homeobox protein KNAT1 (PubMed:25039392)

Belongs to the WIP C2H2-type zinc-finger protein family


This is Isovaleryl-CoA dehydrogenase, mitochondrial protein, from Mouse-ear cress, contains 409 amino acids, locates in Mitochondrion.

Involved in degradation of the branched-chain amino acids, phytol and lysine for the supply of carbon and electrons to the ETF/ETFQO complex during dark-induced sugar starvation

Belongs to the acyl-CoA dehydrogenase family


This is Protein FAR-RED IMPAIRED RESPONSE 1 protein, from Mouse-ear cress, contains 827 amino acids, has 1 SWIM-type Zinc finger, locates in Nucleus.

SWIM-type

Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CACGCGC-3', Activates the expression of FHY1 and FHL involved in light responses, Positive regulator of chlorophyll biosynthesis via the activation of HEMB1 gene expression


This is Protein PHYTOCHROME KINASE SUBSTRATE 1 protein, from Mouse-ear cress, contains 439 amino acids, is membrane-bound, locates in Cell membrane.

May be responsible for light-regulated cytoplasmic sequestration of phytochromes or may be a negative regulator of phytochrome B signaling, Component of the network that modulates the very low-fluence response (VLFR) branch of phyA signaling, Acts positively in PHOT1 signaling, Regulates phytochrome-mediated photomorphogenesis and hypocotyl phototropism, Involved in the control of leaf flattening and leaf positioning, Promotes negative root phototropism and negatively regulates root gravitropism, May act by controlling auxin homeostasis


This is ATP-dependent Clp protease adapter protein CLPS1, chloroplastic protein, from Mouse-ear cress, contains 159 amino acids, is soluble, locates in Plastid.

Small adapter protein that modulate the activity of CLPC (By similarity), Involved in plastid biogenesis in particular when chloroplast protein synthesis capacity is a limiting factor (PubMed:23898032), Probably involved in substrate selection for plastid Clp protease system (PubMed:23898032), Recruitment to ClpC chaperones is facilitated by CLPF thus forming a binary adapter for selective substrate recognition and delivery to plastid Clp protease system (CLPC) (PubMed:26419670)


This is Protein OSB1, mitochondrial protein, from Mouse-ear cress, contains 261 amino acids, locates in Mitochondrion.

Regulates mitochondrial DNA recombination, Represses homologous recombination, preventing mitochondrial genome instability and unbalanced transmission of alternative mtDNA configurations, Binds preferentially single-stranded DNA, Does not bind to RNA


This is G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 protein, from Mouse-ear cress, contains 842 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Alpha-mannosidase I MNS5 protein, from Mouse-ear cress, contains 574 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Can convert Man(9)GlcNAc(2) and Man(8)GlcNAc(2) into N-glycans with a terminal alpha-1,6-linked Man residue in the C-branch, Functions in the formation of unique N-glycan structures that are specifically recognized by components of the endoplasmic reticulum-associated degradation (ERAD) machinery, which leads to the degradation of misfolded glycoproteins, Most likely generates N-glycan signal on misfolded glycoproteins that is subsequently recognized by OS9, Required for ERAD of the heavily glycosylated and misfolded BRI1 variants BRI1-5 and BRI1-9, Does not seem to play role in N-glycan processing of correctly folded proteins destined for secretion

Belongs to the glycosyl hydrolase 47 family


This is Chaperone protein ClpC2, chloroplastic protein, from Mouse-ear cress, contains 952 amino acids, is membrane-bound, locates in Plastid.

Molecular chaperone (PubMed:15304652, PubMed:21737456, PubMed:24599948), May act as a suppressor of FtsH-mediated thylakoid membrane biogenesis and may enhance photoinhibition (PubMed:15304652), Seems not involved in chloroplastic protein import (PubMed:15304652), Probable component of the TIC-associated stromal import motor involved in inner membrane translocation (PubMed:17376159), Has an ATPase activity, but no ADPase activity (PubMed:21737456), Interacts with transit peptides with a positional preference (PubMed:21737456, PubMed:22545953), Localization of the signal sequence at the N-terminal end of a protein seems mandatory for interaction to take place (PubMed:22545953)

Belongs to the ClpA/ClpB family, ClpC subfamily


This is Photosystem I chlorophyll a/b-binding protein 3-1, chloroplastic protein, from Mouse-ear cress, contains 273 amino acids, is membrane-bound, locates in Plastid.

The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated, here photosystem I

Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family


This is Trihelix transcription factor ASIL1 protein, from Mouse-ear cress, contains 383 amino acids, locates in Nucleus.

Transcription repressor that binds specific DNA sequence such as the GT-box-like motif 5'-CGTGATT-3' in the AT2S3 promoter, Negative regulator of seed maturation genes during seed germination and seedling development, May target GT-box-containing embryonic genes by competing with the binding of transcriptional activators to this promoter region (PubMed:19155348), Contributes to the maintenance and control of seed filling (PubMed:22231199) and may repress the maturation program during early embryogenesis (PubMed:21330492)


This is Beta-hexosaminidase 2 protein, from Mouse-ear cress, contains 580 amino acids, is membrane-bound, locates in Cell membrane.

Has a broad substrate specificity, Can use synthetic substrates such as p-nitrophenyl-beta-N-acetylglucosaminide, p-nitrophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside (pNP-GlcNAc), p-nitrophenyl-2-acetamido-2-deoxy-beta-D-galactopyranoside (pNP-GalNAc), 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside (MU-GlcNAc), and 4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-D-glucopyranoside (MU-GlcNAc-6SO(4)) as substrates, Removes terminal GlcNAc residues from alpha1,3- and alpha1,6-mannosyl branches of biantennary N-glycans without any strict branch preference

Belongs to the glycosyl hydrolase 20 family


This is Protein VTE6, chloroplastic protein, from Mouse-ear cress, contains 333 amino acids, is membrane-bound, locates in Plastid.

Phytyl-phosphate kinase catalyzing the conversion of phytyl-monophosphate to phytyl-diphosphate (PubMed:26452599), Involved in the activation and reutilization of phytol from chlorophyll degradation in plant metabolism, including tocopherol (vitamin E) biosynthesis (PubMed:26452599), Involved in the biosynthesis of phylloquinone (vitamin K), which is required for the photosystem I (PSI) complex stability (PubMed:28007557)


This is B-box zinc finger protein 22 protein, from Mouse-ear cress, contains 299 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger, locates in Nucleus.

B box-type 1; atypical

B box-type 2; atypical

Acts as positive regulator of seedling photomorphogenesis and light-regulated inhibition of hypocotyl elongation, independently and in concert with HY5 and BBX21 (PubMed:18540109, PubMed:18796637, PubMed:18182030, PubMed:21427283), Acts as a positive regulator of de-etiolation and influences chloroplast biogenesis and function through regulation of genes encoding chloroplast proteins (PubMed:18182030), Acts downstream of COP1 and plays an important role in early and long-term adjustment of the shade avoidance syndrome (SAS) responses in natural environments (PubMed:21070414), Regulates the expression of genes responsive to light hormone signals which may contribute to optimal seedling development (PubMed:21427283)


This is Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1 protein, from Mouse-ear cress, contains 669 amino acids, is soluble, locates in Cytoplasm.

Trifunctional enzyme involved in UDP-beta-L-rhamnose biosynthesis, a precursor of the primary cell wall components rhamnogalacturonan I (RG-I) and rhamnogalacturonan II (RG-II) (PubMed:14671019, PubMed:17190829, PubMed:19056285), Plays a major role in supplying UDP-rhamnose for flavonol biosynthesis (PubMed:18757557), Catalyzes the dehydration of UDP-glucose to form UDP-4-dehydro-6-deoxy-D-glucose followed by the epimerization of the C3' and C5' positions of UDP-4-dehydro-6-deoxy-D-glucose to form UDP-4-keto-beta-L-rhamnose and the reduction of UDP-4-keto-beta-L-rhamnose to yield UDP-beta-L-rhamnose (By similarity)

In the C-terminal section; belongs to the dTDP-4-dehydrorhamnose reductase family


This is Receptor protein kinase CLAVATA1 protein, from Mouse-ear cress, contains 980 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the detection of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance, Acts with CLV3p as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation


This is Peroxisome biogenesis factor 10 protein, from Mouse-ear cress, contains 381 amino acids, has 1 RING-type Zinc finger, is membrane-bound, locates in Peroxisome.

RING-type

E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:12883010, PubMed:14576288, PubMed:17215364, PubMed:17478547, PubMed:20679226, PubMed:23336935, PubMed:25214533), The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity), PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:23336935, PubMed:25214533), When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity)


This is Photosystem I chlorophyll a/b-binding protein 2, chloroplastic protein, from Mouse-ear cress, contains 257 amino acids, is membrane-bound, locates in Plastid.


This is Glycerophosphodiester phosphodiesterase GDPDL3 protein, from Mouse-ear cress, contains 759 amino acids, is membrane-bound, locates in Cell membrane.

Involved in primary cell wall organization, Required for the accumulation of crystalline cellulose

Belongs to the glycerophosphoryl diester phosphodiesterase family


This is Fatty acid desaturase 4, chloroplastic protein, from Mouse-ear cress, contains 323 amino acids, is membrane-bound, locates in Plastid.

Fatty acid desaturase involved in the production of chloroplast-specific phosphatidylglycerol molecular species containing 16:1(3E), Catalyzes the formation of a trans double bond introduced close to the carboxyl group of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol

Belongs to the fatty acid desaturase CarF family


This is Nudix hydrolase 14, chloroplastic protein, from Mouse-ear cress, contains 309 amino acids, locates in Plastid.

Mediates the hydrolysis of some nucleoside diphosphate derivatives, Can use ADP-glucose, ADP-mannose and ADP-ribose as substrates, Regulates the intracellular ADP-glucose levels linked to starch biosynthesis


This is Cell division cycle 20.1, cofactor of APC complex protein, from Mouse-ear cress, contains 457 amino acids, locates in Nucleus.

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle

Belongs to the WD repeat CDC20/Fizzy family


This is Copper-transporting ATPase PAA1, chloroplastic protein, from Mouse-ear cress, contains 949 amino acids, is membrane-bound, locates in Plastid.

Mediates copper transfer across the plastid envelope, Required for the delivery of copper into the plastid stroma, which is essential for the function of copper proteins, Seems to be selective for monovalent copper Cu(+) transport, Also plays a role in glucose signaling-mediated cell proliferation of root meristem in non-green tissues

Belongs to the cation transport ATPase (P-type) (TC 3,A,3) family, Type IB subfamily


This is RNA-binding KH domain-containing protein PEPPER protein, from Mouse-ear cress, contains 495 amino acids, locates in Nucleus.

Regulates vegetative and gynoecium development (PubMed:16356489), In concert with HUA2, antagonizes FLK by positively regulating FLC probably at transcriptional and post-transcriptional levels, and thus acts as a negative regulator of flowering (PubMed:19576878)


This is Cadmium/zinc-transporting ATPase HMA2 protein, from Mouse-ear cress, contains 951 amino acids, is membrane-bound, locates in Cell membrane.

Plays an important role in zinc transport and homeostasis, Could also be involved in cadmium detoxification


This is NAD(P)H-quinone oxidoreductase subunit S, chloroplastic protein, from Mouse-ear cress, contains 250 amino acids, is membrane-bound, locates in Plastid.

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain, The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone, Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (Probable), Required for the efficient operation of ferredoxin-dependent plastoquinone reduction, Forms the electron donor-binding subcomplex in association with the NDHT and NDHU subunits (PubMed:21505067, PubMed:24225949)


This is UDP-glucose 4-epimerase 2 protein, from Mouse-ear cress, contains 350 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the interconversion between UDP-glucose and UDP-galactose (Ref,6, PubMed:16644739, PubMed:19754426), Cooperates with UGE3 in pollen development and with UGE4 in cell wall carbohydrate biosynthesis and growth (PubMed:17496119)

Belongs to the NAD(P)-dependent epimerase/dehydratase family


This is Protein PAM71-homolog, chloroplastic protein, from Mouse-ear cress, contains 359 amino acids, is membrane-bound, locates in Plastid.

Probable chloroplast-localized Mn(2+)/H(+) and/or Ca(2+)/H(+) antiporter regulating Ca(2+), Mn(2+) and pH homeostasis


This is Probable cyclin-dependent kinase 9 protein, from Caenorhabditis elegans, contains 478 amino acids, locates in Nucleus.

Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily


This is Calcium/calmodulin-dependent protein kinase type 1 protein, from Caenorhabditis elegans, contains 348 amino acids, locates in Nucleus.

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation (PubMed:10428833, PubMed:12231504, PubMed:26725111), Transcriptional activation occurs at least in part through phosphorylation of crh-1 (PubMed:10428833, PubMed:12231504), Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons (PubMed:10428833, PubMed:14711416, PubMed:25467978), Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature (PubMed:25467978), Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious heat and controls neuropeptide release from FLP neurons in response to temperature elevations (PubMed:25467982), Regulates the dauer decision, the decision of the larvae to enter into the alternative stress-resistant and long-lived dauer developmental stage, based on the feeding state, primarily in the AWC sensory neurons, Acts non cell-autonomously in the AWC neurons to regulate expression of the daf-28 insulin-like peptide and cell-autonomously in the ASI sensory neurons to regulate expression of the growth promoting daf-7 in a food-regulated manner (PubMed:26335407), Plays a role in memory-based thermal response of an individual AFD neuron cell (PubMed:26725111), Involved in chemotaxis response in AWC neurons to attractant 2-heptanone, a volatile organic compound emitted by the nematode pathogenic bacterium B,nematocida B16 (PubMed:27660389), Plays a role in a type of aversive gustatory associated learning called salt avoidance learning via regulation of crh-1 signaling and the promotion of long-term memory formation (PubMed:30779740), Represses transcription of glutamate receptor glr-1 in the nucleus basally and in response to change in synaptic activity (PubMed:27462879)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily


This is Serine/threonine-protein kinase chk-2 protein, from Caenorhabditis elegans, contains 476 amino acids, locates in Nucleus.

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks, May also negatively regulate cell cycle progression during unperturbed cell cycles, Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis, Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, CHK2 subfamily


This is Neuronal acetylcholine receptor subunit eat-2 protein, from Caenorhabditis elegans, contains 474 amino acids, is membrane-bound, locates in Cell membrane.

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity), Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping (PubMed:15020415, PubMed:8601480), Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity (PubMed:8462849, PubMed:9789046, PubMed:15141086, PubMed:28853436, PubMed:30965033), Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine (PubMed:30965033)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily


This is 5'-3' exoribonuclease 2 homolog protein, from Caenorhabditis elegans, contains 975 amino acids, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

Possesses 5'->3' exoribonuclease activity (PubMed:19734881, PubMed:21397849), Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA (PubMed:19734881, PubMed:21397849, PubMed:26779609), Degradation role is enhanced when in complex with paxt-1 (PubMed:24462208, PubMed:26779609), Partially redundant to xrn-1 in miRNA guide strand degradation (PubMed:19734881, PubMed:21397849), Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA (PubMed:19734881, PubMed:21397849), Positively regulates molting of the pharyngeal cuticle (PubMed:16122351, PubMed:19734881)

Belongs to the 5'-3' exonuclease family, XRN2/RAT1 subfamily


This is Zyxin protein, from Caenorhabditis elegans, contains 603 amino acids, locates in Cytoplasm.

Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus) (PubMed:23427270), Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development (PubMed:25252943)


This is Transcription factor grauzone protein, from Fruit fly, contains 570 amino acids, has 8 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor essential for the completion of meiosis in oocytes, Grauzone binds to the promoter region of cort via the zf-AD domain and activates cort expression in ovaries


This is Delta-conotoxin TxVIA protein, from Cloth-of-gold cone, contains 78 amino acids, is soluble, locates in Extracellular.

Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process, Binding of this toxin is strongly calcium-dependent but not voltage-dependent, The binding site is most likely on the extracellular side of the sodium channel, Binds receptor sites on both mollusk and rat central nervous system, but despite its high affinity binding to rat sodium channel, it has no functional effect in vivo and in vitro on it, Has also no effect on Gambusia fish, Is important in mollusk for the paralysis of the prey, Upon injection of the peptide, a subordinate lobster assumes an exaggerated dominant posture (of a 'King-Kong' lobster!)


This is Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 protein, from Fruit fly, contains 700 amino acids, is membrane-bound, locates in Nucleus.

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs, May methylate the ribose of the second nucleotide of a m(7)GpppG-capped mRNA (cap0) to produce m(7)GpppRmpNm (cap2) (By similarity), Regulates expression of tracheal genes required for pathfinding on the segmental nerve (PubMed:10068643)


This is Methyl-CpG-binding domain protein 2 protein, from Human, contains 411 amino acids, locates in Nucleus.

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669), Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175), Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852), Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666), Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179), Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179), May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568)


This is DNA (cytosine-5)-methyltransferase 3B protein, from Human, contains 853 amino acids, has 1 GATA-type; atypical Zinc finger, has 1 PHD-type; atypical Zinc finger, locates in Nucleus.

GATA-type; atypical

PHD-type; atypical

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development, DNA methylation is coordinated with methylation of histones, May preferentially methylates nucleosomal DNA within the nucleosome core region, May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation, Seems to be involved in gene silencing (By similarity), In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9, Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs, Functions as a transcriptional corepressor by associating with ZHX1, Required for DUX4 silencing in somatic cells (PubMed:27153398)

Belongs to the class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family


This is Ammonium transporter Rh type C protein, from Human, contains 479 amino acids, is membrane-bound, locates in Cell membrane.

Ammonium transporter involved in the maintenance of acid-base homeostasis, Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism, Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+), As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989), May act as a CO2 channel providing for renal acid secretion (PubMed:24077989)

Belongs to the ammonium transporter (TC 2,A,49) family, Rh subfamily


This is SUMO-activating enzyme subunit 1 protein, from Human, contains 346 amino acids, locates in Nucleus.

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4, It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2

Belongs to the ubiquitin-activating E1 family


This is Cornulin protein, from Human, contains 495 amino acids, is soluble, locates in Cytoplasm.

Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832), Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832)

Belongs to the S100-fused protein family


This is P2X purinoceptor 2 protein, from Human, contains 471 amino acids, is membrane-bound, locates in Cell membrane.

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis, In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling, Mediates synaptic transmission between neurons and from neurons to smooth muscle


This is 7-dehydrocholesterol reductase protein, from Human, contains 475 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway


This is tRNA (guanine-N(7)-)-methyltransferase protein, from Human, contains 276 amino acids, locates in Nucleus.

Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031083, PubMed:31031084, PubMed:36599982, PubMed:36599985), Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (PubMed:12403464, PubMed:34352207, PubMed:34352206, PubMed:36599982, PubMed:36599985), M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (PubMed:36599982, PubMed:36599985), Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084), Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084), Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083), N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083), Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity)

Belongs to the class I-like SAM-binding methyltransferase superfamily, TrmB family


This is PTB domain-containing engulfment adapter protein 1 protein, from Human, contains 304 amino acids, is soluble, locates in Cytoplasm.

May function as an adapter protein, Required for efficient phagocytosis of apoptotic cells, Modulates cellular glycosphingolipid and cholesterol transport, May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP, Increases cellular levels of GTP-bound ARF6


This is DnaJ homolog subfamily B member 11 protein, from Human, contains 358 amino acids, is soluble, locates in Endoplasmic reticulum.

As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351), Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676), May help recruiting HSPA5 and other chaperones to the substrate, Stimulates HSPA5 ATPase activity (PubMed:10827079), It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351)


This is DNA polymerase kappa protein, from Human, contains 870 amino acids, has 2 UBZ4-type Zinc finger, locates in Nucleus.

DNA polymerase specifically involved in DNA repair, Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls, Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts, Lacks 3'-5' proofreading exonuclease activity, Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity

Belongs to the DNA polymerase type-Y family


This is Nuclear RNA export factor 1 protein, from Human, contains 619 amino acids, locates in Cytoplasm.

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507), The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949), ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949), Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)


This is Protein sel-1 homolog 1 protein, from Human, contains 794 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207), Enhances SYVN1 stability, Plays a role in LPL maturation and secretion, Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells, May play a role in Notch signaling


This is Double homeobox protein 4 protein, from Human, contains 424 amino acids, locates in Nucleus.

Probably inactive as a transcriptional activator, due to the absence of the C-terminal region that is important for transcriptional activation, Can inhibit transcriptional activation mediated by isoform 1, Heterologous expression of isoform 2 has no deleterious effect on cell survival


This is Fibulin-5 protein, from Human, contains 448 amino acids, is soluble, locates in Extracellular.

Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537), Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity), Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif, Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823), May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108)


This is Protein CLN8 protein, from Human, contains 286 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Could play a role in cell proliferation during neuronal differentiation and in protection against cell death


This is Tripartite motif-containing protein 10 protein, from Human, contains 481 amino acids, has 1 RING-type Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type

E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells, May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity), In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity, Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647)


This is Mucosa-associated lymphoid tissue lymphoma translocation protein 1 protein, from Human, contains 824 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, locates in Cytoplasm.

Ig-like C2-type

Ig-like C2-type

Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955), Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101), Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101), Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity), Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753), May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475)


This is Serine/threonine-protein kinase 17A protein, from Human, contains 414 amino acids, locates in Nucleus.

Acts as a positive regulator of apoptosis, Also acts as a regulator of cellular reactive oxygen species

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, DAP kinase subfamily


This is CGG triplet repeat-binding protein 1 protein, from Human, contains 167 amino acids, locates in Nucleus.

Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter, May play a role in regulating FMR1 promoter


This is Peptide chain release factor 1-like, mitochondrial protein, from Human, contains 380 amino acids, locates in Mitochondrion.

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG

Belongs to the prokaryotic/mitochondrial release factor family


This is Solute carrier family 23 member 2 protein, from Human, contains 650 amino acids, is membrane-bound, locates in Cell membrane.

Sodium/ascorbate cotransporter (PubMed:10471399, PubMed:10556521), Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10471399)

Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2,A,40) family


This is Neuronal acetylcholine receptor subunit alpha-9 protein, from Human, contains 479 amino acids, is membrane-bound, locates in Cell membrane.

Ionotropic receptor with a probable role in the modulation of auditory stimuli, Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151), The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151), In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing, This may protect against acoustic trauma, May also regulate keratinocyte adhesion (PubMed:11021840)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily, Alpha-9/CHRNA9 sub-subfamily


This is Zinc finger CCCH domain-containing protein 7B protein, from Human, contains 977 amino acids, has 4 C3H1-type Zinc finger, has 1 C2H2-type Zinc finger, locates in Nucleus.

May be a specific regulator of miRNA biogenesis, Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop


This is Sushi domain-containing protein 2 protein, from Human, contains 822 amino acids, is membrane-bound, locates in Cell membrane.

May be a cytokine receptor for GPR15LG, May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403), May play a role in breast tumorigenesis (PubMed:23131994)


This is DNA dC->dU-editing enzyme APOBEC-3B protein, from Human, contains 382 amino acids, locates in Nucleus.

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms, After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA, The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells, Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA, Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons

Belongs to the cytidine and deoxycytidylate deaminase family


This is Kelch-like protein 3 protein, from Human, contains 587 amino acids, is soluble, locates in Cytoplasm.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031), The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031), The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity)


This is Serine/threonine-protein kinase TBK1 protein, from Human, contains 729 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359, PubMed:32404352), Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800), This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995), In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807), Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653), Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800), Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631), Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227), Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041), Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069), Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703), Phosphorylates and activates AKT1 (PubMed:21464307), Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity), Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402), Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125), Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily


This is Septin-9 protein, from Human, contains 586 amino acids, is soluble, locates in Cytoplasm.

Filament-forming cytoskeletal GTPase (By similarity), May play a role in cytokinesis (Potential), May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family


This is Epidermal growth factor-like protein 7 protein, from Human, contains 273 amino acids, is soluble, locates in Extracellular.

Regulates vascular tubulogenesis in vivo, Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis


This is Inositol hexakisphosphate kinase 2 protein, from Human, contains 426 amino acids, locates in Nucleus.

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5)

Belongs to the inositol phosphokinase (IPK) family


This is Solute carrier family 23 member 1 protein, from Human, contains 598 amino acids, is membrane-bound, locates in Cell membrane.


This is Scm-like with four MBT domains protein 1 protein, from Human, contains 866 amino acids, locates in Nucleus.

Histone-binding protein, which is part of various corepressor complexes, Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription, Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1, Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes, Part of the SLC complex in germ cells, where it may play a role during spermatogenesis


This is FMR1-interacting protein NUFIP1 protein, from Human, contains 495 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.


This is Nuclear prelamin A recognition factor protein, from Human, contains 456 amino acids, locates in Nucleus.


This is Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 protein, from Human, contains 511 amino acids, is soluble, locates in Cytoplasm.

May function as adapter protein, Involved in the formation of clusters of actin bundles, Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection


This is Poly(U)-binding-splicing factor PUF60 protein, from Human, contains 559 amino acids, locates in Nucleus.

DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation, In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor, Acts as a transcriptional repressor through the core-TFIIH basal transcription factor, Represses FUBP1-induced transcriptional activation but not basal transcription, Decreases ERCC3 helicase activity, Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells, Is also involved in pre-mRNA splicing, Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2, Involved in apoptosis induction when overexpressed in HeLa cells, Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer, Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells, Modulates alternative splicing of several mRNAs, Binds to relaxed DNA of active promoter regions, Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2, Binds to Y5 RNA in association with RO60, Binds to poly(U) RNA


This is Glutaminase liver isoform, mitochondrial protein, from Human, contains 602 amino acids, locates in Mitochondrion.

Plays an important role in the regulation of glutamine catabolism, Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate, Increases cellular anti-oxidant function via NADH and glutathione production, May play a role in preventing tumor proliferation


This is Dachshund homolog 1 protein, from Human, contains 758 amino acids, locates in Nucleus.

Transcription factor that is involved in regulation of organogenesis, Seems to be a regulator of SIX1, SIX6 and probably SIX5, Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex, Transcriptional activation seems also to involve association of CREBBP, Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity), Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1, Binds to chromatin DNA via its DACHbox-N domain (By similarity)


This is rRNA methyltransferase 2, mitochondrial protein, from Human, contains 246 amino acids, locates in Mitochondrion.

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA

Belongs to the class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family


This is Cytohesin-4 protein, from Human, contains 394 amino acids, is membrane-bound, locates in Cell membrane.

Promotes guanine-nucleotide exchange on ARF1 and ARF5, Promotes the activation of ARF factors through replacement of GDP with GTP


This is SLAM family member 5 protein, from Human, contains 345 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like C2-type

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response, Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2, Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity), Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process, Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway, May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647, PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation, In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity), In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234), In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity), Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592)


This is Zinc finger protein 639 protein, from Human, contains 485 amino acids, has 8 C2H2-type Zinc finger, locates in Nucleus.

Binds DNA and may function as a transcriptional repressor

Belongs to the krueppel C2H2-type zinc-finger protein family


This is GTP:AMP phosphotransferase AK3, mitochondrial protein, from Human, contains 227 amino acids, is soluble, locates in Mitochondrion.

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates, Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities

Belongs to the adenylate kinase family, AK3 subfamily


This is PHD finger protein 11 protein, from Human, contains 331 amino acids, has 1 C2HC pre-PHD-type Zinc finger, has 1 PHD-type Zinc finger, locates in Nucleus.

C2HC pre-PHD-type

PHD-type

Positive regulator of Th1-type cytokine gene expression


This is Potassium voltage-gated channel subfamily G member 1 protein, from Human, contains 513 amino acids, is membrane-bound, locates in Cell membrane.

Potassium channel subunit that does not form functional channels by itself, Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135)

Belongs to the potassium channel family, G (TC 1,A,1,2) subfamily, Kv6,1/KCNG1 sub-subfamily


This is Cardiolipin synthase (CMP-forming) protein, from Human, contains 301 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG), CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions

Belongs to the CDP-alcohol phosphatidyltransferase class-I family


This is Protein Hook homolog 1 protein, from Human, contains 728 amino acids, is soluble, locates in Cytoplasm.

Component of the FTS/Hook/FHIP complex (FHF complex) (PubMed:18799622, PubMed:32073997), The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622), FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997), Required for spermatid differentiation, Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity)


This is Kelch-like protein 21 protein, from Human, contains 597 amino acids, is soluble, locates in Cytoplasm.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis, The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB, Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome


This is Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial protein, from Human, contains 675 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871), Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton, Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871)

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Testis-specific serine kinase substrate protein, from Human, contains 592 amino acids, is soluble, locates in Cytoplasm.

May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development


This is Dynactin subunit 4 protein, from Human, contains 460 amino acids, is soluble, locates in Cytoplasm.

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules

Belongs to the dynactin subunit 4 family


This is Tubulointerstitial nephritis antigen protein, from Human, contains 476 amino acids, is soluble, locates in Extracellular.

Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3, This is a non catalytic peptidase C1 family protein


This is SERTA domain-containing protein 3 protein, from Human, contains 196 amino acids, locates in Nucleus.

Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (PubMed:33147462, PubMed:36594413), Plays a role in the late phase response of TLR-induced immune effector expression (By similarity), During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex (PubMed:33147462), Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation (PubMed:36594413), Strong transcriptional coactivator (PubMed:10982866)


This is Growth/differentiation factor 2 protein, from Human, contains 429 amino acids, is soluble, locates in Extracellular.

Potent circulating inhibitor of angiogenesis, Signals through the type I activin receptor ACVRL1 but not other Alks, Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG


This is N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase protein, from Human, contains 515 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step, Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases


This is Zinc finger protein 580 protein, from Human, contains 172 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Involved in the regulation of endothelial cell proliferation and migration, Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation, May be involved in transcriptional regulation


This is Cyclin-L1 protein, from Human, contains 526 amino acids, is soluble, locates in Nucleus.

Involved in pre-mRNA splicing, Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018), Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906), May play a role in the regulation of RNA polymerase II (pol II), May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036)

Belongs to the cyclin family, Cyclin L subfamily


This is Cytoplasmic phosphatidylinositol transfer protein 1 protein, from Human, contains 332 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the transfer of phosphatidylinositol between membranes

Belongs to the PtdIns transfer protein family, PI transfer class IIB subfamily


This is Serine/threonine-protein kinase tousled-like 1 protein, from Human, contains 766 amino acids, locates in Nucleus.

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase, This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly, Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin, Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs, In vitro, phosphorylates histone H3 at 'Ser-10'

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is REST corepressor 1 protein, from Human, contains 485 amino acids, locates in Nucleus.

Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells, The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier, In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval, Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates, It also protects KDM1A from the proteasome, Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation


This is Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase protein, from Human, contains 699 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation, It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)

Belongs to the glycosyl hydrolase 47 family


This is Isobutyryl-CoA dehydrogenase, mitochondrial protein, from Human, contains 415 amino acids, locates in Mitochondrion.

Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway (PubMed:11013134, PubMed:12359132, PubMed:16857760), To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA (PubMed:11013134, PubMed:12359132)

Belongs to the acyl-CoA dehydrogenase family


This is Nuclear pore complex protein Nup50 protein, from Human, contains 468 amino acids, is membrane-bound, locates in Nucleus.

Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008), Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008), Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity), This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity)


This is Zinc fingers and homeoboxes protein 1 protein, from Human, contains 873 amino acids, has 2 C2H2-type Zinc finger, locates in Nucleus.

Acts as a transcriptional repressor, Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA, May link molecule between DNMT3B and other co-repressor proteins


This is Protein O-mannosyl-transferase 2 protein, from Human, contains 750 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues, Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (PubMed:14699049, PubMed:28512129), Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins (PubMed:28512129)

Belongs to the glycosyltransferase 39 family


This is Integrator complex subunit 6 protein, from Human, contains 887 amino acids, locates in Nucleus.

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing, The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable), Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267), May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144)

Belongs to the Integrator subunit 6 family


This is Protein argonaute-1 protein, from Human, contains 857 amino acids, is soluble, locates in Cytoplasm.

Required for RNA-mediated gene silencing (RNAi), Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them, Lacks endonuclease activity and does not appear to cleave target mRNAs, Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs)

Belongs to the argonaute family, Ago subfamily


This is Zinc finger protein 346 protein, from Human, contains 294 amino acids, has 4 Matrin-type Zinc finger, locates in Cytoplasm.

Matrin-type

Matrin-type

Matrin-type

Matrin-type

Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053), May bind to specific miRNA hairpins (PubMed:28431233)


This is Paraneoplastic antigen Ma2 protein, from Human, contains 364 amino acids, locates in Nucleus.


This is Transcription factor-like 5 protein protein, from Human, contains 500 amino acids, locates in Nucleus.

Putative transcription factor, Isoform 3 may play a role in early spermatogenesis


This is Aspartyl aminopeptidase protein, from Human, contains 485 amino acids, is soluble, locates in Cytoplasm.

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus, Likely to play an important role in intracellular protein and peptide metabolism


This is Malignant T-cell-amplified sequence 1 protein, from Human, contains 181 amino acids, is soluble, locates in Cytoplasm.

Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition, When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation, Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes, Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits, Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant, Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation, Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells, May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis, May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis, Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3, Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes, Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits


This is Protein NDRG4 protein, from Human, contains 352 amino acids, is soluble, locates in Cytoplasm.

Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity), May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF, May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner


This is TBC1 domain family member 24 protein, from Human, contains 559 amino acids, is soluble, locates in Cytoplasm.

May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515, PubMed:20797691), Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515), Involved in the regulation of synaptic vesicle trafficking (PubMed:31257402)


This is Striatin-interacting protein 2 protein, from Human, contains 834 amino acids, is soluble, locates in Cytoplasm.

Plays a role in the regulation of cell morphology and cytoskeletal organization, Required in the control of cell shape


This is E3 ubiquitin-protein ligase ZNRF3 protein, from Human, contains 936 amino acids, has 1 RING-type; atypical Zinc finger, is membrane-bound, locates in Cell membrane.

RING-type; atypical

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6, Acts on both canonical and non-canonical Wnt signaling pathway, Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959), Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)


This is RNA-binding protein NOB1 protein, from Human, contains 412 amino acids, has 1 NOB1 Zinc finger, locates in Nucleus.

May play a role in mRNA degradation (Probable), Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity)


This is A-kinase anchor protein 8-like protein, from Human, contains 646 amino acids, has 2 C2H2 AKAP95-type Zinc finger, locates in Cytoplasm.

C2H2 AKAP95-type

C2H2 AKAP95-type

(Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity


This is Y+L amino acid transporter 1 protein, from Human, contains 511 amino acids, is membrane-bound, locates in Cell membrane.

Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux routeby exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine (PubMed:9878049, PubMed:9829974, PubMed:17329401, PubMed:10080182, PubMed:10655553, PubMed:15756301, PubMed:15776427, PubMed:14603368), Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells (PubMed:15280038, PubMed:31705628), The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity), In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity)

Belongs to the amino acid-polyamine-organocation (APC) superfamily, L-type amino acid transporter (LAT) (TC 2,A,3,8) family


This is Lysosomal thioesterase PPT2 protein, from Human, contains 302 amino acids, locates in Lysosome/Vacuole.

Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA, Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates, However, because of structural constraints, is unable to remove palmitate from peptides or proteins

Belongs to the palmitoyl-protein thioesterase family


This is Nucleolar protein 7 protein, from Human, contains 257 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome


This is DNA polymerase iota protein, from Human, contains 740 amino acids, locates in Nucleus.

Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224), Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127), Favors Hoogsteen base-pairing in the active site (PubMed:15254543), Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543), Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228), May play a role in hypermutation of immunoglobulin genes (PubMed:12410315), Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940)

Belongs to the DNA polymerase type-Y family


This is Tumor necrosis factor ligand superfamily member 18 protein, from Human, contains 177 amino acids, is membrane-bound, locates in Cell membrane.

Cytokine that binds to TNFRSF18/AITR/GITR, Regulates T-cell responses, Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation, Important for interactions between activated T-lymphocytes and endothelial cells, Mediates activation of NF-kappa-B, Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569), Promotes leukocyte adhesion to endothelial cells (PubMed:23892569), Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity)

Belongs to the tumor necrosis factor family


This is Probable dimethyladenosine transferase protein, from Human, contains 313 amino acids, locates in Nucleus.

Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604), Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Belongs to the class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family


This is WD repeat-containing protein 3 protein, from Human, contains 943 amino acids, locates in Nucleus.

Belongs to the WD repeat WDR3/UTP12 family


This is B9 domain-containing protein 1 protein, from Human, contains 204 amino acids, is soluble, locates in Cytoplasm.

Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes, Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)


This is Serine/threonine-protein phosphatase 6 regulatory subunit 1 protein, from Human, contains 881 amino acids, is soluble, locates in Cytoplasm.

Regulatory subunit of protein phosphatase 6 (PP6), May function as a scaffolding PP6 subunit, Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha


This is Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 protein, from Human, contains 857 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5, Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system

Belongs to the centaurin gamma-like family


This is Microtubule-associated protein RP/EB family member 3 protein, from Human, contains 281 amino acids, is soluble, locates in Cytoplasm.

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:28814570, PubMed:19255245), Promotes microtubule growth (PubMed:28814570, PubMed:19255245), May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes (PubMed:28814570, PubMed:19255245), Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570), Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570)


This is Paraplegin protein, from Human, contains 795 amino acids, is membrane-bound, locates in Mitochondrion.

ATP-dependent zinc metalloprotease, Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735)

In the C-terminal section; belongs to the peptidase M41 family


This is Superoxide dismutase [Mn], mitochondrial protein, from Fission yeast, contains 218 amino acids, is soluble, locates in Mitochondrion.

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems

Belongs to the iron/manganese superoxide dismutase family


This is Vacuolar transporter chaperone complex subunit 1 protein, from Fission yeast, contains 122 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Accessory subunit of the vacuolar transporter chaperone (VTC) complex, The VTC complex acts as vacuolar polyphosphate polymerase that catalyzes the synthesis of inorganic polyphosphate (polyP) via transfer of phosphate from ATP to a growing polyP chain, releasing ADP, VTC exposes its catalytic domain vtc4 to the cytosol, where the growing polyP chain winds through a tunnel-shaped pocket, integrating cytoplasmic polymer synthesis with polyP membrane translocation, The VTC complex carries 9 vacuolar transmembrane domains, which are likely to constitute the translocation channel into the organelle lumen, PolyP synthesis is tightly coupled to its transport into the vacuole lumen, in order to avoid otherwise toxic intermediates in the cytosol, and it depends on the proton gradient across the membrane, formed by V-ATPase, Vtc1 contributes only 3 transmembrane domains to the complex, The VTC complex also plays a role in vacuolar membrane fusion (By similarity), Involved in the control of cell polarity (PubMed:10628977)


This is NAD-dependent protein deacetylase hst4 protein, from Fission yeast, contains 415 amino acids, locates in Nucleus.

NAD-dependent histone deacetylase, which contributes to both telomeric and centromeric silencing, proper cell cycle progression, DNA damage control, recombination, and genomic maintenance

Belongs to the sirtuin family, Class I subfamily


This is Fructose-bisphosphate aldolase protein, from Yeast, contains 359 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis

Belongs to the class II fructose-bisphosphate aldolase family


This is Serine/threonine-protein kinase ppk16 protein, from Fission yeast, contains 672 amino acids, is soluble, locates in Cytoplasm.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Glucosidase 2 subunit alpha protein, from Fission yeast, contains 923 amino acids, locates in Endoplasmic reticulum.

Catalytic subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins

Belongs to the glycosyl hydrolase 31 family


This is Kinesin-like protein 3 protein, from Fission yeast, contains 554 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic motor that could play a role in Golgi membrane recycling

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family


This is Protein dom34 protein, from Fission yeast, contains 390 amino acids, is soluble, locates in Cytoplasm.

Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290), In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (By similarity), Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity)

Belongs to the eukaryotic release factor 1 family, Pelota subfamily


This is Golgi apyrase protein, from Fission yeast, contains 572 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates, Required for Golgi glycosylation and cell wall integrity, Involved in N-mannosylation of proteins in Golgi