This is Polycomb protein esc protein, from Fruit fly, contains 425 amino acids, locates in Nucleus.

Polycomb group (PcG) protein, While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state, Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene, The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required


This is Fringe glycosyltransferase protein, from Fruit fly, contains 412 amino acids, is membrane-bound, locates in Golgi apparatus.

Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling, Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats, Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development

Belongs to the glycosyltransferase 31 family


This is Lachesin protein, from Fruit fly, contains 359 amino acids, has 1 Ig-like V-type Immunoglobulin domain, has 2 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Ig-like C2-type

Ig-like C2-type

Required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier, Functions as a homophilic cell-adhesion molecule, May play a role in early neuronal differentiation and axon outgrowth


This is Glutamate [NMDA] receptor subunit 1 protein, from Fruit fly, contains 997 amino acids, is membrane-bound, locates in Cell membrane.

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium, Mediated by glycine, This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning, It mediates neuronal functions in glutamate neurotransmission, Is involved in the cell surface targeting of NMDA receptors, Plays a role in associative learning and in long-term memory consolidation

Belongs to the glutamate-gated ion channel (TC 1,A,10,1) family


This is Retinoblastoma family protein protein, from Fruit fly, contains 845 amino acids, locates in Nucleus.

Functions in cell cycle regulation, Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context, In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci, During development, the complex represses transcription of developmentally controlled E2F target genes

Belongs to the retinoblastoma protein (RB) family


This is Syntaxin-5 protein, from Fruit fly, contains 467 amino acids, is membrane-bound, locates in Golgi apparatus.

Mediates endoplasmic reticulum to Golgi transport


This is Chromatin assembly factor 1 p55 subunit protein, from Fruit fly, contains 430 amino acids, locates in Nucleus.

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA, Component of several complexes which regulate chromatin metabolism, These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the nucleosome remodeling factor (NURF) complex, which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin; and the polycomb group (PcG) repressor complex ESC-E(Z), which promotes repression of homeotic genes during development, Also required for transcriptional repression of E2F target genes by E2f2 and Rbf or Rbf2

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family


This is Protein dead ringer protein, from Fruit fly, contains 911 amino acids, locates in Nucleus.

Transcription factor which is a downstream target of gcm and repo, Directly or indirectly activates the transcription of locos and pros, which are essential for the development of some glial cells, Plays an essential role in defining the cell shape and migration characteristics of longitudinal glia that enable them to establish a normal axon scaffold


This is Cathepsin L-like proteinase protein, from Liver fluke, contains 326 amino acids, is soluble, locates in Extracellular.

Thiol protease, Probably involved in interaction with host tissues, Displays a similar activity to that of papain, Has high activity on Z-Phe-Arg-NHMec, but no activity on Z-Arg-NHMec


This is Thiosulfate/3-mercaptopyruvate sulfurtransferase 2 protein, from Mouse-ear cress, contains 342 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds, Substrate preference is 3-mercaptopyruvate > thiosulfate, Involved in embryo and seed development


This is Phenoloxidase subunit 2 protein, from Tobacco hawkmoth, contains 695 amino acids, is soluble, locates in Extracellular.

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds, Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinone, Binds to the surface of hemocytes and is involved in hemocyte melanization


This is Akirin-2 protein, from Rat, contains 201 amino acids, locates in Nucleus.

Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is involved in embryonic development, immunity, myogenesis and brain development (By similarity), Plays a key role in nuclear protein degradation by promoting import of proteasomes into the nucleus: directly binds to fully assembled 20S proteasomes at one end and to nuclear import receptor IPO9 at the other end, bridging them together and mediating the import of pre-assembled proteasome complexes through the nuclear pore (By similarity), Involved in innate immunity by regulating the production of interleukin-6 (IL6) downstream of Toll-like receptor (TLR): acts by bridging the NF-kappa-B inhibitor NFKBIZ and the SWI/SNF complex, leading to promote induction of IL6, Also involved in adaptive immunity by promoting B-cell activation, Involved in brain development: required for the survival and proliferation of cerebral cortical progenitor cells, Involved in myogenesis: required for skeletal muscle formation and skeletal development, possibly by regulating expression of muscle differentiation factors, Also plays a role in facilitating interdigital tissue regression during limb development (By similarity)


This is Protein ripply2.2 protein, from African clawed frog, contains 153 amino acids, locates in Nucleus.

Required during somitogenesis for the formation of somite boundaries, Represses the expression of genes involved in somite segmentation by acting with the corepressor tle4 to down-regulate the transcriptional activity of tbx6, May act by regulating the activity of tle4, Represses transcription of delta2, thy1 and ripply2,2/bowline itself


This is Acetylcholine receptor subunit beta-type lev-1 protein, from Caenorhabditis elegans, contains 507 amino acids, is membrane-bound, locates in Cell membrane.

Non-alpha subunit of nicotinic acetylcholine receptor (nAChR), Involved in nAChR sensitivity to nicotine

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily


This is ATP-dependent RNA helicase WM6 protein, from Fruit fly, contains 424 amino acids, locates in Nucleus.

Required for mRNA export out of the nucleus, Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis, Binds to salivary gland chromosomes and modifies position effect variegation, Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin

Belongs to the DEAD box helicase family, DECD subfamily


This is RNA-binding protein cabeza protein, from Fruit fly, contains 399 amino acids, has 1 RanBP2-type Zinc finger, locates in Nucleus.

May participate in a function common to the expression of most genes transcribed by RNA polymerase II


This is Protein sine oculis protein, from Fruit fly, contains 416 amino acids, locates in Nucleus.

Required for visual system development, May transcriptionally regulate genes necessary for optic lobe invagination and Bolwig's nerve formation

Belongs to the SIX/Sine oculis homeobox family


This is Transcription factor glial cells missing protein, from Fruit fly, contains 504 amino acids, locates in Nucleus.

Transcription factor that induces gliogenesis, It determines the choice between glial and neuronal fates, Also has a role in the differentiation of the plasmatocyte/macrophage lineage of hemocytes


This is Nucleoplasmin-like protein protein, from Fruit fly, contains 152 amino acids, locates in Nucleus.

Inactive for chromatin assembly, In vitro it appears to form a high molecular mass aggregate with the core histones


This is Peroxisomal catalase 1 protein, from Caenorhabditis elegans, contains 500 amino acids, locates in Peroxisome.

Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity (PubMed:25243607, PubMed:28456303), Plays a role in maintaining normal lifespan (PubMed:14996832), Plays a role in regulating the response to pathogens such as E,faecalis (PubMed:17483415)


This is ATP-dependent Clp protease proteolytic subunit 1, mitochondrial protein, from Caenorhabditis elegans, contains 221 amino acids, is soluble, locates in Mitochondrion.

Clp cleaves peptides in various proteins in a process that requires ATP hydrolysis, Clp may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates


This is Serine/threonine-protein phosphatase 6 catalytic subunit protein, from Fruit fly, contains 303 amino acids, is soluble, locates in Cytoplasm.

May be involved in controlling cellularization or in regulating transcription of the genes involved in this process

Belongs to the PPP phosphatase family, PP-6 (PP-V) subfamily


This is Protein phyllopod protein, from Fruit fly, contains 400 amino acids, locates in Nucleus.

Essential adapter component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, embryonic nervous system, external sensory organ development and specification of particular muscles, E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins, Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation, Acts downstream of Notch signaling to specify the fate of the SOP (sensory organ precursor) cells and their progeny, probably via the sina-mediated proteasomal degradation of ttk, Its restricted pattern of expression, upon Notch and Ras signaling pathways, suggests that it acts as a key determinant in E3 complexes to trigger protein proteolysis in appropriate cells


This is Venom plasminogen activator LV-PA protein, from Bushmaster, contains 258 amino acids, is soluble, locates in Extracellular.

Snake venom serine protease that activates plasminogen, Weakly hydrolyzes the alpha chain of human fibrinogen without releasing fibrinopeptide A, Does not hydrolyze plasma kallikrein or factor Xa, Does not clot fibrinogen, Does not affect platelet function, Induces hypotensive effects on rats, Shows a preferential cleavage at Lys-|-Xaa over Arg-|-Xaa bonds

Belongs to the peptidase S1 family, Snake venom subfamily


This is Bradykinin-potentiating and C-type natriuretic peptides protein, from Bushmaster, contains 239 amino acids, is soluble, locates in Extracellular.

Snake venom natriuretic peptide that exhibits hypotensive and vasodepressor activity, Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity)

In the C-terminal section; belongs to the natriuretic peptide family


This is Sodium/hydrogen exchanger 3 protein, from North American opossum, contains 839 amino acids, is membrane-bound, locates in Cell membrane.

Plasma membrane Na(+)/H(+) antiporter, Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis, Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2,A,36) family


This is Mitoferrin-1 protein, from Zebrafish, contains 332 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is ER degradation-enhancing alpha-mannosidase-like protein 3 protein, from Mouse, contains 931 amino acids, is soluble, locates in Endoplasmic reticulum.

Involved in endoplasmic reticulum-associated degradation (ERAD), Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans, May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD (PubMed:34143952), May have alpha 1,2-mannosidase activity

Belongs to the glycosyl hydrolase 47 family


This is C-type lectin domain family 12 member B protein, from Human, contains 276 amino acids, is membrane-bound, locates in Cell membrane.

Inhibitory receptor postulated to negatively regulate immune and non-immune functions (PubMed:17562706, PubMed:34310951), Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (PubMed:17562706, PubMed:34310951), Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (PubMed:17562706), May limit activation of myeloid cell subsets in response to infection or tissue inflammation (PubMed:17562706), May protect target cells against natural killer cell-mediated lysis (PubMed:17562706), May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (PubMed:34310951)


This is Protein moonraker protein, from Human, contains 967 amino acids, is soluble, locates in Cytoplasm.

Involved in centriole duplication (PubMed:24613305, PubMed:26297806), Positively regulates CEP63 centrosomal localization (PubMed:24613305, PubMed:26297806), Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806), May play a role in cilium assembly


This is Glycine N-acyltransferase protein, from Bovine, contains 295 amino acids, locates in Mitochondrion.

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently, Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid

Belongs to the glycine N-acyltransferase family


This is Sporulation-specific protein 5 protein, from Fission yeast, contains 567 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein which plays a role in sporulation, Regulates the progression of meiosis I and may function in the vicinity of the Mei2 dot


This is Protein canopy-1 protein, from Zebrafish, contains 187 amino acids, locates in Endoplasmic reticulum.

Involved in the maintenance of the midbrain-hindbrain boundary (MHB) organizer, Contributes to a positive-feedback loop of FGF signaling in the MHB, enabling the MHB to exert its role as an organizer for the tectal and cerebellar development


This is Protein Wnt-3a protein, from Chicken, contains 352 amino acids, is soluble, locates in Extracellular.

Ligand for members of the frizzled family of seven transmembrane receptors (Probable), Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:17488271), Regulates chick apical ectodermal ridge formation (PubMed:17488271), Required for normal embryonic mesoderm development and formation of caudal somites, Required for normal morphogenesis of the developing neural tube (By similarity)


This is Transmembrane protein 266 protein, from Human, contains 531 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529), Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529), Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529), Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529)


This is Probable E3 ubiquitin-protein ligase IRF2BPL protein, from Rhesus macaque, contains 794 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins, Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway, Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity), Also acts as a transcriptional regulator of genes controlling female reproductive function, May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)


This is Myocyte-specific enhancer factor 2A protein, from Rat, contains 495 amino acids, locates in Nucleus.

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes, Also involved in the activation of numerous growth factor- and stress-induced genes, Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival, Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription, In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation, Associates with chromatin to the ZNF16 promoter (By similarity)


This is Beta/kappa-theraphotoxin-Cg2a protein, from Chinese earth tiger tarantula, contains 83 amino acids, is soluble, locates in Extracellular.

This gating-modifier toxin shows an important inhibitory activity on sodium channels (PubMed:29723257), It is very active on Nav1,7/SCN9A (IC(50)~0,6 nM), and also shows activity on Nav1,3/SCN3A (IC(50)=292 nM), Nav1,4/SCN4A (IC(50)=2,2-159 nM), and Nav1,5/SCN5A (IC(50)=2,3-2,9 uM) (PubMed:25055801, PubMed:29723257), It has also been shown to inhibit tetrodotoxin (TTX)-resistant (IC(50)=27,6 nM) and TTX-sensitive (IC(50)=30,2 nM) sodium channels in rat dorsal root ganglion neurons (PubMed:17157888), Lower inhibitory activity has also been shown on potassium channels: Kv4,2/KCND2 (IC(50)=604,2 nM), Kv4,3/KCND3 (IC(50)=425,1 nM), and Kv2,1/KCNB1 (IC(50)=14,3 uM) (PubMed:17157888, PubMed:20571743, PubMed:17150181), It binds to phospholipid membranes, Like its analog AM-8145, it may act by interacting only with the second voltage-sensor domain of Nav1,7/SCN9A (Probable)

Belongs to the neurotoxin 30 (phrixotoxin) family


This is Bradykinin-potentiating and C-type natriuretic peptides protein, from Brazilian rattlesnake, contains 181 amino acids, is soluble, locates in Extracellular.


This is Kinesin-1 heavy chain protein, from Rat, contains 963 amino acids, is soluble, locates in Cytoplasm.

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes, Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity), Regulates centrosome and nuclear positioning during mitotic entry, During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (By similarity), Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (PubMed:23576431), Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends, Involved in NK cell-mediated cytotoxicity, Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity)

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin subfamily


This is Ubiquitin-like-specific protease 1D protein, from Mouse-ear cress, contains 584 amino acids, locates in Nucleus.

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins, Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5, Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3, Protease activity mainly directed at deconjugating SUM1 and SUM2 from their target proteins, Regulates salt stress responses and flowering time, Redundant with ULP1C


This is Pyruvate kinase 1, cytosolic protein, from Rice, contains 527 amino acids, is soluble, locates in Cytoplasm.

Key regulatory enzyme of the glycolytic pathway that catalyzes the final step of glycolysis, converting ADP and phosphoenolpyruvate (PEP) to ATP and pyruvate by essentially irreversible transphosphorylation, Is critical for plant growth and development


This is Peroxisomal leader peptide-processing protease protein, from Human, contains 566 amino acids, locates in Peroxisome.

Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins, Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids


This is Dynamin-like 120 kDa protein, mitochondrial protein, from Rat, contains 960 amino acids, is membrane-bound, locates in Mitochondrion.

Isoforms that contain the alternative exon 4b (present in isoform 2 and isoform 3, but not in isoform 1) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is Apelin receptor B protein, from African clawed frog, contains 363 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:17412318), Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (By similarity), Promotes angioblast migration toward the embryonic midline, i,e, the position of the future vessel formation, during vasculogenesis (By similarity), May promote sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity), Required for cardiovascular development, particularly for intersomitic vein angiogenesis by acting as a receptor for apln hormone (PubMed:17412318), Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure, Acts upstream of the i/o type of G-alpha proteins in the differentiation of endothelium, erythroid cells, myeloid cells and cardiomyocytes (By similarity)

Belongs to the G-protein coupled receptor 1 family


This is PWWP domain-containing DNA repair factor 3A protein, from Human, contains 710 amino acids, locates in Nucleus.

Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture, Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation, Required for efficient DNA repair and cell survival following DNA damage


This is NF-kappa-B inhibitor delta protein, from Mouse, contains 327 amino acids, locates in Nucleus.

Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity, Functions in the regulation of inflammatory responses (PubMed:11931770, PubMed:15749903, PubMed:16410444, PubMed:16413922, PubMed:17641034), Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160), According to PubMed:11931770, it may also regulate TCR-induced negative selection of thymocytes (PubMed:11931770)

Belongs to the NF-kappa-B inhibitor family


This is High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor protein, from Mouse, contains 535 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Functions as a receptor for the Fc fragment of IgA and IgM, Binds IgA and IgM with high affinity and mediates their endocytosis, May function in the immune response to microbes mediated by IgA and IgM


This is Kelch-like protein 40 protein, from Human, contains 621 amino acids, is soluble, locates in Cytoplasm.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development (PubMed:23746549), The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex (By similarity), Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity)


This is R-spondin-3 protein, from Mouse, contains 277 amino acids, is soluble, locates in Extracellular.

Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis (PubMed:16543246, PubMed:21693646, PubMed:26766444), Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes, Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway, Acts as a ligand for frizzled FZD8 and LRP6, May negatively regulate the TGF-beta pathway (PubMed:16543246, PubMed:21693646), Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (PubMed:26766444, PubMed:16543246, PubMed:21693646), Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (By similarity)


This is Zinc metalloproteinase-disintegrin-like EoVMP2 protein, from Ocellated saw-scaled viper, contains 613 amino acids, is soluble, locates in Extracellular.

Snake venom zinc metalloprotease that possesses high hemorrhagic activity, It inhibits collagen-induced platelet aggregation and activates prothrombin (F2)

Belongs to the venom metalloproteinase (M12B) family, P-III subfamily, P-IIIa sub-subfamily


This is MLX-interacting protein protein, from Mouse, contains 917 amino acids, locates in Cytoplasm.

Binds DNA as a heterodimer with MLX and activates transcription, Binds to the canonical E box sequence 5'-CACGTG-3', Plays a role in transcriptional activation of glycolytic target genes, Involved in glucose-responsive gene regulation


This is Carcinoembryonic antigen-related cell adhesion molecule 16 protein, from Human, contains 425 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C2-type

Ig-like C2-type

Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane

Belongs to the immunoglobulin superfamily, CEA family


This is Protein ripply1 protein, from Zebrafish, contains 140 amino acids, locates in Nucleus.

Plays a role in somitogenesis, Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites


This is Erythropoietin protein, from Zebrafish, contains 183 amino acids, is soluble, locates in Extracellular.

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass


This is Hereditary hemochromatosis protein protein, from Human, contains 348 amino acids, has 1 Ig-like C1-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C1-type

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin


This is cAMP-responsive element-binding protein-like 2 protein, from Mouse, contains 123 amino acids, locates in Nucleus.

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation, May also play a regulatory role in the cell cycle

Belongs to the bZIP family, ATF subfamily


This is Anoctamin-4 protein, from Human, contains 955 amino acids, is membrane-bound, locates in Cell membrane.

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity), Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity)


This is Zinc finger protein 750 protein, from Human, contains 723 amino acids, has 1 C2H2-type; degenerate Zinc finger, locates in Nucleus.

C2H2-type; degenerate

Transcription factor involved in epidermis differentiation, Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes, Specifically binds to the promoter of KLF4 and promotes its expression


This is Lysine-specific demethylase JMJ706 protein, from Rice, contains 858 amino acids, locates in Nucleus.

Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me3 and H3K9me2, No activity on H3K4me3, H3K9me1, H3K27me2 and H3K36me3/2, Involved in the control of floral organ development by demethylating H3K9me3 and H3K9me2 in the promoter regions of DH1 and MADS47, The 'Lys-9' demethylation of these two genes is required for induction of their expression


This is ATP-dependent protease subunit HslV protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 209 amino acids, is soluble, locates in Mitochondrion.

Protease subunit of a proteasome-like degradation complex, HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis, HslV is not believed to degrade folded proteins (By similarity), The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels

Belongs to the peptidase T1B family, HslV subfamily


This is ATP-dependent DNA helicase PIF1 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 929 amino acids, locates in Mitochondrion.

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability, Essential for replication of kinetoplast minicircles, Involved in the segregation of minicircle progeny

Belongs to the helicase family, PIF1 subfamily


This is Avenacosidase 1 protein, from Oat, contains 574 amino acids, is soluble, locates in Plastid.

Beta-glucosidase acting as a preformed defense system, Hydrolyzes the bisdesmosides avenacosides A and B to 26-desgluco-avenacosides exhibiting fungicidal activity, Can use beta-fucoside > beta-glucoside > beta-galactoside > beta-xyloside as substrates, but not alpha-glycosides, beta-thioglucosides and disaccharides

Belongs to the glycosyl hydrolase 1 family


This is 3-ketoacyl-CoA synthase 18 protein, from Mouse-ear cress, contains 506 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Contributes to fatty acids elongation and stockage in developing seeds, Active on both saturated and mono-unsaturated acyl-CoAs of 16 and 18 carbons, Required for the elongation of C18 to C20 and of C20 to C22 fatty acids, Mediates also the synthesis of VLCFAs from 20 to 26 carbons in length (e,g, C20:1, C20, C22:1, C22, C24:1, C24, C26) (PubMed:15277688, PubMed:16765910, PubMed:7734965, PubMed:9263455, Ref,4, Ref,5, PubMed:12135493, PubMed:23145136), Has no activity with polyunsaturated C18:2 and C18:3 or with acyl-CoAs having 22 carbons or longer chain length (PubMed:12135493)

Belongs to the thiolase-like superfamily, Chalcone/stilbene synthases family


This is Inositol-3-phosphate synthase isozyme 2 protein, from Mouse-ear cress, contains 510 amino acids, is soluble, locates in Cytoplasm.

Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner

Belongs to the myo-inositol 1-phosphate synthase family


This is Calcium-dependent protein kinase 9 protein, from Mouse-ear cress, contains 541 amino acids, is membrane-bound, locates in Cell membrane.

May play a role in signal transduction pathways that involve calcium as a second messenger

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDPK subfamily


This is Calcium-dependent protein kinase 2 protein, from Mouse-ear cress, contains 646 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is Calcium-dependent protein kinase 6 protein, from Mouse-ear cress, contains 544 amino acids, is membrane-bound, locates in Cell membrane.

May play a role in signal transduction pathways that involve calcium as a second messenger, Functions in abscisic acid (ABA) regulation of guard cell S-type anion- and Ca(2+)-permeable channels and stomatal closure (PubMed:17032064), Phosphorylates FD (PubMed:25661797)


This is Calcium-dependent protein kinase 7 protein, from Mouse-ear cress, contains 535 amino acids, is membrane-bound, locates in Cell membrane.


This is Homeobox protein SHOOT MERISTEMLESS protein, from Mouse-ear cress, contains 382 amino acids, locates in Nucleus.

Required for shoot apical meristem (SAM) formation during embryogenesis, Negatively regulates ASYMMETRIC LEAVES1 (AS1) and ASYMMETRIC LEAVES2 (AS2 or LBD6), Probably binds to the DNA sequence 5'-TGAC-3', Binds to RNA (By similarity)

Belongs to the TALE/KNOX homeobox family


This is Endoglucanase 25 protein, from Mouse-ear cress, contains 621 amino acids, is membrane-bound, locates in Cell membrane.

Required for cellulose microfibrils formation, Involved in cell wall assembly during cell elongation and cell plate maturation in cytokinesis, Required for secondary cell wall formation in the developing xylem, May cycle through different intracellular compartments, including plasma membrane

Belongs to the glycosyl hydrolase 9 (cellulase E) family


This is Homeobox protein BEL1 homolog protein, from Mouse-ear cress, contains 611 amino acids, locates in Nucleus.

Plays a major role in ovule patterning and in determination of integument identity via its interaction with MADS-box factors, Formation of complex with AG-SEP dimers negatively regulates the carpel identity process and favors the maintenance of ovule identity, BEL1-STM complex maintains the indeterminacy of the inflorescence meristem, Required, with SPL, for cytokinin-induced PIN1 expression in ovules (PubMed:22786869)

Belongs to the TALE/BELL homeobox family


This is Peptidyl-prolyl cis-trans isomerase CYP19-1 protein, from Mouse-ear cress, contains 173 amino acids, is soluble, locates in Cytoplasm.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Involved in reactive oxygen species production in response to pathogen infection

Belongs to the cyclophilin-type PPIase family


This is Translocase of chloroplast 34, chloroplastic protein, from Mouse-ear cress, contains 313 amino acids, is membrane-bound, locates in Plastid.

GTPase involved in protein precursor import into chloroplasts, Seems to recognize chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis, Probably specialized in the import of nuclear encoded non-photosynthetic preproteins from the cytoplasm to the chloroplast

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, TOC34 subfamily


This is Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 370 amino acids, locates in Nucleus.

S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of spliced leader and U1 small nuclear RNAs, Methylates the ribose of the first nucleotide of a m(7)GpppG-capped RNA to produce m(7)GpppNmp (cap1), Cap1 modification is linked to higher levels of translation, Recognizes a guanosine cap on RNA independent of its N(7) methylation status


This is ATP-dependent DNA helicase PIF6 protein, from Trypanosoma brucei brucei (strain 927/4 GUTat10.1), contains 796 amino acids, locates in Nucleus.

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability


This is Phosphoinositide phospholipase C 2 protein, from Mouse-ear cress, contains 581 amino acids, is membrane-bound, locates in Cell membrane.

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes, At physiological calcium concentration, the preferred substrate is phosphatidylinositol 4,5-bisphosphate versus phosphatidylinositol


This is Acid beta-fructofuranosidase 4, vacuolar protein, from Mouse-ear cress, contains 664 amino acids, locates in Lysosome/Vacuole.

Possible role in the continued mobilization of sucrose to sink organs (PubMed:20207708), Regulates root elongation (PubMed:16481625)

Belongs to the glycosyl hydrolase 32 family


This is GTP 3',8-cyclase, mitochondrial protein, from Mouse-ear cress, contains 390 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate

Belongs to the radical SAM superfamily, MoaA family


This is Zinc finger protein CONSTANS protein, from Mouse-ear cress, contains 373 amino acids, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type 2; atypical Zinc finger, locates in Nucleus.

B box-type 1; atypical

B box-type 2; atypical

Transcription factor that acts in the long day flowering pathway and may mediate between the circadian clock and the control of flowering, Plays a role in the regulation of flowering time by acting on 'SUPPRESSOR OF OVEREXPRESSION OF CO1', 'TERMINAL FLOWER 1' and 'FLOWERING LOCUS T', Also regulates P5CS2 and ACS10 (involved in proline and ethylene biosynthesis, respectively), Regulates the expression of NAKR1 by binding to the 5'-TGTG(N2-3)ATG-3' motif (PubMed:27255839)


This is Delta(24)-sterol reductase protein, from Mouse-ear cress, contains 561 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plays a critical role in the general process of plant cell elongation, Involved in the synthesis of campesterol, an early precursor of brassinolide, Required for the conversion of 24-methylenecholesterol to campesterol and for the conversion of isofucosterol to sitosterol, Necessary for both the isomerization and reduction of 24-methylenecholesterol, Regulates indirectly phytochrome-mediated light responses through the modulation of brassinosteroid biosynthesis


This is Protein PALE CRESS, chloroplastic protein, from Mouse-ear cress, contains 313 amino acids, locates in Plastid.

Required for the differentiation of chloroplast from proplastids or etioplasts, probably by modulating some chloroplast-encoded genes expression and mRNA maturation, Involved in leaf-cells differentiation


This is ATP-dependent zinc metalloprotease FTSH 1, chloroplastic protein, from Mouse-ear cress, contains 716 amino acids, is membrane-bound, locates in Plastid.

Part of a complex that function as an ATP-dependent zinc metallopeptidase, Involved in the thylakoid formation and in the removal of damaged D1 in the photosystem II, preventing cell death under high-intensity light conditions

In the C-terminal section; belongs to the peptidase M41 family


This is Thiosulfate sulfurtransferase 16, chloroplastic protein, from Mouse-ear cress, contains 120 amino acids, locates in Plastid.

Thought to act during the early stages of leaf senescence, Catalyzes the transfer of a sulfur ion from a donor to cyanide or to other thiol compounds, Substrate preference is thiosulfate > 3-mercaptopyruvate


This is Ferredoxin--nitrite reductase, chloroplastic protein, from Mouse-ear cress, contains 586 amino acids, locates in Plastid.

Catalyzes the six-electron reduction of nitrite to ammonium

Belongs to the nitrite and sulfite reductase 4Fe-4S domain family


This is Lipid transfer protein EARLI 1 protein, from Mouse-ear cress, contains 168 amino acids, is soluble, locates in Extracellular.

Probable lipid transfer protein (LTP), May improve freezing survival, Seems to control the flowering process and lignin synthesis, Has an auxiliary role for germinability and early seedling development under low temperature and salt stress conditions, probably in an abscisic acid- (ABA) dependent manner, Confers resistance to Botrytis cinerea and exhibits anti-fungal activity, at least against S,cerevisiae, B,cinerea and Fusarium oxysporum, probably by increasing their membrane permeability

Belongs to the plant LTP family, PEARLI1 subfamily


This is G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 protein, from Mouse-ear cress, contains 797 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Transcription factor MYC2 protein, from Mouse-ear cress, contains 623 amino acids, locates in Nucleus.

Transcriptional activator, Common transcription factor of light, abscisic acid (ABA), and jasmonic acid (JA) signaling pathways, With MYC3 and MYC4, controls additively subsets of JA-dependent responses, In cooperation with MYB2 is involved in the regulation of ABA-inducible genes under drought stress conditions, Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis, Binds to the MYC recognition site (5'-CACATG-3'), and to the G-box (5'-CACNTG-3') and Z-box (5'-ATACGTGT-3') of promoters, Binds directly to the promoters of the transcription factors PLETHORA1 (PLT1) and PLT2 and represses their expression, Negative regulator of blue light-mediated photomorphogenic growth and blue- and far-red-light regulated gene expression, Activates multiple TIFY/JAZ promoters, Positive regulator of lateral root formation, Regulates sesquiterpene biosynthesis, Subjected to proteasome-dependent proteolysis, The presence of the destruction element (DE) involved in turnover is required for the function to regulate gene transcription


This is Serine acetyltransferase 3, mitochondrial protein, from Mouse-ear cress, contains 391 amino acids, locates in Mitochondrion.

Belongs to the transferase hexapeptide repeat family


This is Violaxanthin de-epoxidase, chloroplastic protein, from Mouse-ear cress, contains 462 amino acids, is membrane-bound, locates in Plastid.

Part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts, Catalyzes the two-step mono de-epoxidation reaction, Stereospecific for all-trans xanthophylls, Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II

Belongs to the calycin superfamily, Lipocalin family


This is V-type proton ATPase subunit E1 protein, from Mouse-ear cress, contains 230 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function, V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, Required for Golgi organization and vacuole function in embryogenesis

Belongs to the V-ATPase E subunit family


This is Glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a protein, from Cucumber, contains 725 amino acids, locates in Peroxisome.

In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family


This is Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial protein, from Rat, contains 443 amino acids, is soluble, locates in Mitochondrion.

Involved in the heme biosynthesis, Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity)

Belongs to the aerobic coproporphyrinogen-III oxidase family


This is Nucleobase-ascorbate transporter 12 protein, from Mouse-ear cress, contains 709 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2,A,40) family


This is Protein GOLVEN 11 protein, from Mouse-ear cress, contains 116 amino acids, is soluble, locates in Extracellular.

Acts as a peptide hormone recognized by receptors (e,g, RGI1 and RGI2) to trigger signaling events including the regulation of RITF1 expression and leading to the production of reactive oxygen species (ROS) in roots to modulate meristem size (PubMed:31801996), Signaling peptide (root growth factor) that maintains the postembryonic root stem cell niche in a PIN2-traffic dependent manner by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT), mainly at the post-transcriptional level (PubMed:20798316, PubMed:23370719), Maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (e,g, PLT1 and PLT2), mainly at the post-transcriptional level (PubMed:20798316), Influences circumferential cell number in the root meristem in response to Pi-deprivation (PubMed:25856240), Regulates the pattern of root growth and lateral root development by modulating the length and the number of cortical cells in the root apical meristem (RAM), and the anticlinal asymmetric cell divisions in lateral root initiation cells (PubMed:22307643, PubMed:23370719)


This is Receptor-like protein kinase ANXUR2 protein, from Mouse-ear cress, contains 858 amino acids, is membrane-bound, locates in Cell membrane.

Receptor-like protein kinase that controls pollen tube behavior by directing rupture at proper timing to release the sperm cell


This is Protein inscuteable homolog protein, from Mouse, contains 579 amino acids, is soluble, locates in Cytoplasm.

May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex, Involved in spindle orientation during mitosis (PubMed:16301171, PubMed:21816348), May regulate cell proliferation and differentiation in the developing nervous system (PubMed:16301171), May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (PubMed:16094321)


This is Dynein axonemal assembly factor 6 protein, from Mouse, contains 218 amino acids, is soluble, locates in Cytoplasm.

Plays a role in cytoplasmic pre-assembly of axonemal dynein


This is Polycomb group RING finger protein 3 protein, from Human, contains 242 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development, PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility, Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332), Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity)


This is Transcription factor Sox-17-alpha-A protein, from African clawed frog, contains 380 amino acids, locates in Nucleus.

Transcriptional activator, Binds to the DNA sequence 5'-AACAAT-3' (By similarity), All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function, In addition, the sox17 proteins have distinct but overlapping roles in later gut development, Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly, Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling


This is Pyranose dehydrogenase protein, from White button mushroom, contains 594 amino acids, is soluble, locates in Extracellular.

Catalyzes the single-oxidation or sequential double oxidation reaction of carbohydrates primarily at carbon-2 and/or carbon-3 with the concomitant reduction of the flavin, The enzyme exhibits a broad sugar substrate specificity, oxidizing different aldopyranoses to the corresponding C-1, C-2, C-3 or C-1,2, C-2,3 and C-3,4 (di)dehydro sugars with substrate-specific regioselectivity, Accepts only a narrow range of electron acceptors such as substituted benzoquinones and complexed metal ions and reacts extremely slowly with O(2) as acceptor, May play a role in the natural recycling of plant matter by oxidizing all major monosaccharides in lignocellulose and by reducing quinone compounds or reactive radical species generated during lignin depolymerization

Belongs to the GMC oxidoreductase family


This is Pyranose dehydrogenase 1 protein, from Western flat-topped agaric, contains 602 amino acids, is soluble, locates in Extracellular.


This is N-acetyllactosaminide alpha-1,3-galactosyltransferase protein, from Rat, contains 371 amino acids, is membrane-bound, locates in Golgi apparatus.

Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid, Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3)

Belongs to the glycosyltransferase 6 family


This is Exocrine gland-secreted peptide 1 protein, from Mouse, contains 102 amino acids, is soluble, locates in Extracellular.

Male-specific phermone which is recognized by the Vmn2r116/V2rp5 receptor in the vomeronasal organ (VNO) and enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation

Belongs to the exocrine gland-secreted peptide family


This is Lon protease homolog 2, peroxisomal protein, from Rat, contains 852 amino acids, is soluble, locates in Peroxisome.

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix, Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import, May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1


This is Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y protein, from Human, contains 71 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815), May act by regulating the catalytic subunit PIGA (PubMed:16162815)


This is Inactive hydroxysteroid dehydrogenase-like protein 1 protein, from Human, contains 330 amino acids, locates in Mitochondrion.

Belongs to the short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily


This is Keratin, type II cytoskeletal 71 protein, from Human, contains 523 amino acids, is soluble, locates in Cytoplasm.

Plays a central role in hair formation, Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle

Belongs to the intermediate filament family


This is 2-acylglycerol O-acyltransferase 2 protein, from Human, contains 334 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA, Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0, Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes, May play a role in diet-induced obesity, Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)

Belongs to the diacylglycerol acyltransferase family


This is Putative phospholipase B-like 2 protein, from Mouse, contains 594 amino acids, is soluble, locates in Lysosome/Vacuole.

Belongs to the phospholipase B-like family


This is Testicular spindle-associated protein SHCBP1L protein, from Mouse, contains 639 amino acids, is soluble, locates in Cytoplasm.

Testis-specific spindle-associated factor that plays a role in spermatogenesis (PubMed:24557841), In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells (PubMed:24557841)


This is Metal transporter CNNM2 protein, from Mouse, contains 875 amino acids, is membrane-bound, locates in Cell membrane.

Divalent metal cation transporter, Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+)


This is Serine/arginine-rich splicing factor 6 protein, from Mouse, contains 339 amino acids, locates in Nucleus.

Plays a role in constitutive splicing and modulates the selection of alternative splice sites, Plays a role in the alternative splicing of MAPT/Tau exon 10, Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC, Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity)

Belongs to the splicing factor SR family


This is Polynucleotide 5'-hydroxyl-kinase NOL9 protein, from Mouse, contains 714 amino acids, locates in Nucleus.

Polynucleotide 5'-kinase involved in rRNA processing, The kinase activity is required for the processing of the 32S precursor into 5,8S and 28S rRNAs, more specifically for the generation of the major 5,8S(S) form, In vitro, has both DNA and RNA 5'-kinase activities, Probably binds RNA (By similarity)

Belongs to the Clp1 family, NOL9/GRC3 subfamily


This is Transmembrane protein 64 protein, from Mouse, contains 381 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Positively regulates TNFSF11-induced osteoclast differentiation, Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation, Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation (PubMed:23395171), Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway, Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1 (PubMed:25979161)


This is Lipase maturation factor 1 protein, from Mouse, contains 574 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in the maturation of specific proteins in the endoplasmic reticulum, Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway, Each LMF1 molecule chaperones 50 or more molecules of LPL

Belongs to the lipase maturation factor family


This is CMRF35-like molecule 7 protein, from Mouse, contains 209 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP


This is Histone-lysine N-methyltransferase KMT5B protein, from Mouse, contains 883 amino acids, locates in Nucleus.

Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:28114273, PubMed:24049080, PubMed:15145825), In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity), H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825), Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825), KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:16612004, PubMed:15750587), Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823), Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity), May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily


This is Monocarboxylate transporter 10 protein, from Mouse, contains 512 amino acids, is membrane-bound, locates in Cell membrane.

Sodium- and proton-independent thyroid hormones and aromatic acids transporter, Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (By similarity), Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:16245314), Plays an important role in homeostasis of aromatic amino acids (PubMed:23045339)

Belongs to the major facilitator superfamily, Monocarboxylate porter (TC 2,A,1,13) family


This is Forkhead box protein K2 protein, from Mouse, contains 651 amino acids, locates in Nucleus.

Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (PubMed:25402684, PubMed:29861159, PubMed:30700909), Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:25402684, PubMed:29861159, PubMed:30700909), Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (PubMed:30700909), Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (PubMed:30700909), Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (PubMed:30700909), Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (PubMed:25402684), In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity), Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity), Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity), Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity)


This is Ubiquitin thioesterase otulin protein, from Mouse, contains 352 amino acids, is soluble, locates in Cytoplasm.

Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response (PubMed:23708998, PubMed:27523608, PubMed:29950720), Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex (PubMed:23708998), Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (By similarity), OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC complex, thereby preventing inactivation of the LUBAC complex (PubMed:29950720), Acts as a key negative regulator of inflammation by restricting spontaneous inflammation and maintaining immune homeostasis (PubMed:27523608, PubMed:29950720), In myeloid cell, required to prevent unwarranted secretion of cytokines leading to inflammation and autoimmunity by restricting linear polyubiquitin formation (PubMed:27523608), Plays a role in innate immune response by restricting linear polyubiquitin formation on LUBAC complex in response to NOD2 stimulation, probably to limit NOD2-dependent pro-inflammatory signaling (By similarity)

Belongs to the peptidase C65 family, Otulin subfamily


This is Heparan-alpha-glucosaminide N-acetyltransferase protein, from Mouse, contains 656 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase


This is N6-adenosine-methyltransferase non-catalytic subunit protein, from Mouse, contains 456 amino acids, locates in Nucleus.

The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24394384, PubMed:28965759), In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity), N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity), M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (PubMed:24394384), In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (PubMed:24394384), M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (PubMed:28914256), M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (PubMed:28965759)


This is Myosin light chain kinase 3 protein, from Mouse, contains 795 amino acids, is soluble, locates in Cytoplasm.

Kinase that phosphorylates MYL2 in vitro (PubMed:18202317, PubMed:17885681), Has been proposed to be calmodulin-dependent (PubMed:17885681), although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin (PubMed:18202317), Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity)

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family


This is Calcium uniporter protein, mitochondrial protein, from Mouse, contains 350 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685886, PubMed:23900286, PubMed:24212091), Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity), Activity is regulated by MICU1 and MICU2 (By similarity), At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (By similarity), Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity), Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity), While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:26119742, PubMed:26119731, PubMed:25603276), Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731), Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity), Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (PubMed:25732818), Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (PubMed:26644474), Involved in antigen processing and presentation (PubMed:25251370)


This is Lysocardiolipin acyltransferase 1 protein, from Mouse, contains 376 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (PubMed:15152008), Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (PubMed:15152008), Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity), Possesses lysophosphatidylinositol acyltransferase (LPIAT) activity (PubMed:20668164), Possesses lysophosphatidylglycerol acyltransferase (LPGAT) activity (By similarity), Required for establishment of the hematopoietic and endothelial lineages (PubMed:17675553)

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family


This is Ubiquitin carboxyl-terminal hydrolase 30 protein, from Mouse, contains 517 amino acids, is membrane-bound, locates in Mitochondrion.

Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy, Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling, Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (By similarity), Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (PubMed:24513856)


This is Src kinase-associated phosphoprotein 2 protein, from Mouse, contains 358 amino acids, is soluble, locates in Cytoplasm.

May be involved in B-cell and macrophage adhesion processes, In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation, May play a role in src signaling pathway


This is Zinc finger and SCAN domain-containing protein 10 protein, from Mouse, contains 782 amino acids, has 14 C2H2-type Zinc finger, locates in Nucleus.

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency, Can both activate and /or repress expression of target genes, depending on the context, Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence, Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4


This is Integrin beta-2-like protein protein, from Mouse, contains 738 amino acids, is membrane-bound, locates in Cell membrane.

During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response

Belongs to the integrin beta chain family


This is Little elongation complex subunit 2 protein, from Mouse, contains 988 amino acids, locates in Nucleus.

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III


This is Putative histone-lysine N-methyltransferase PRDM6 protein, from Mouse, contains 596 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 2 C2H2-type Zinc finger, has 1 C2H2-type 4; degenerate Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate

C2H2-type 4; degenerate

Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression (PubMed:16537907, PubMed:17662997), Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells (PubMed:27181681, PubMed:16537907, PubMed:17662997), Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation, It is unclear whether it has histone methyltransferase activity in vivo, According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a (PubMed:16537907), According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro, 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression (PubMed:17662997)

Belongs to the class V-like SAM-binding methyltransferase superfamily


This is Sulfotransferase 1 family member D1 protein, from Mouse, contains 295 amino acids, is soluble, locates in Cytoplasm.

Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds, Has sulfotransferase activity towards p-nitrophenol, 2-naphthylamine and minoxidil (in vitro), Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites

Belongs to the sulfotransferase 1 family


This is Homeodomain-interacting protein kinase 4 protein, from Mouse, contains 616 amino acids, is soluble, locates in Cytoplasm.

Protein kinase that phosphorylates murine TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter, May act as a corepressor of transcription factors (Potential)

Belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, HIPK subfamily


This is Olfactomedin-like protein 2B protein, from Mouse, contains 746 amino acids, is soluble, locates in Extracellular.


This is Transforming growth factor beta regulator 1 protein, from Human, contains 411 amino acids, locates in Nucleus.

Acts as a growth inhibitor, Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis, Redistributes CDKN2A into the nucleoplasm, Involved in maintaining chromosomal stability


This is Short-chain specific acyl-CoA dehydrogenase, mitochondrial protein, from Bovine, contains 412 amino acids, is soluble, locates in Mitochondrion.

Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats, The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity), Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627)

Belongs to the acyl-CoA dehydrogenase family


This is Golgin subfamily A member 5 protein, from Rat, contains 728 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in maintaining Golgi structure, Stimulates the formation of Golgi stacks and ribbons, Involved in intra-Golgi retrograde transport


This is Zinc-activated ligand-gated ion channel protein, from Human, contains 412 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the ligand-gated ion channel (TC 1,A,9) family


This is 15-cis-phytoene desaturase, chloroplastic/chromoplastic protein, from Daffodil, contains 570 amino acids, is membrane-bound, locates in Plastid.

Converts phytoene into zeta-carotene via the intermediary of phytofluene by the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene with a concomitant isomerization of two neighboring double bonds at the C9 and C9' positions from trans to cis

Belongs to the carotenoid/retinoid oxidoreductase family


This is Guanine nucleotide-binding protein subunit beta protein, from Rice, contains 380 amino acids, is membrane-bound, locates in Cell membrane.

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems, The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Belongs to the WD repeat G protein beta family


This is Oleate hydroxylase FAH12 protein, from Castor bean, contains 387 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Oleate hydroxylase involved in the biosynthesis of ricinoleate (PubMed:7624314, PubMed:27056057), It uses cytochrome b5 as an electron donor (PubMed:1417766), May act on both oleic acid (18:1(9cis)) and eicosenoic acid (20:1(11cis)) (PubMed:8784737)

Belongs to the fatty acid desaturase type 1 family


This is Aquaporin TIP2-1 protein, from Mouse-ear cress, contains 250 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Aquaporin required to facilitate the transport of water from the vacuolar compartment to the cytoplasm, Does not promote glycerol permeability, Its function is impaired by Hg(2+), Transports urea in yeast cells and Xenopus laevis oocytes in a pH-independent manner, Transports methylammonium or ammonium in yeast cells and Xenopus laevis oocytes, preferentially at high medium pH, May participate in vacuolar compartmentation and detoxification of ammonium

Belongs to the MIP/aquaporin (TC 1,A,8) family, TIP (TC 1,A,8,10) subfamily


This is Aquaporin TIP1-2 protein, from Mouse-ear cress, contains 253 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Water channel required to facilitate the transport of water across cell membrane, May be involved in the osmoregulation in plants under high osmotic stress such as under a high salt condition, Transports urea in yeast cells in a pH-independent manner, Transports H(2)O(2) in yeast cells


This is Oxygen-evolving enhancer protein 2-1, chloroplastic protein, from Mouse-ear cress, contains 263 amino acids, locates in Plastid.

May be involved in the regulation of photosystem II


This is LRR receptor-like serine/threonine-protein kinase ERECTA protein, from Mouse-ear cress, contains 976 amino acids, is membrane-bound, locates in Cell membrane.

Receptor kinase that, together with ERL1 and ERL2, regulates aerial architecture, including inflorescence (e,g, shoot apical meristem-originating organ shape, elongation of the internode and pedicels, and adaxial-abaxial polarity), and stomatal patterning (e,g, density and clustering), probably by tuning cell division and expansion, Redundantly involved with ERL1 in procambial development regulation, Forms a functional ligand-receptor pair with EPF2 (AC Q8LC53) (PubMed:22241782), Modulates plant transpiration efficiency by controlling stomatal density, leaf photosynthetic capacity, epidermal cell expansion, mesophyll cell proliferation and cell-cell contact, A phloem-specific expression of ER is sufficient for proper inflorescence architecture (PubMed:22474391), Probable major trait regulating canalization (maintenance of phenotype despite varying environment) in many aspect of the plant physiology (e,g, plant morphology, light-dependent leaves number, branch number, flowering time, phytate and mineral concentrations) by transducing microenvironmental variation into phenotypic differentiation (ecological amplifier), May maintain development integrity in heat stress conditions, Regulates cell wall composition and structure, Confers resistance to the pathogenic bacteria Ralstonia solanacearum and to the necrotrophic fungi Plectosphaerella cucumerina and Pythium irregulare, and required for callose deposition upon infection, Resistance to P,cucumerina seems cell wall-mediated, Forms a constitutive complex with TMM involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN (PubMed:28536146)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Protein pleiotropic regulatory locus 1 protein, from Mouse-ear cress, contains 486 amino acids, locates in Nucleus.

Pleiotropic regulator of glucose, stress and hormone responses, Also regulates cytochrome P450 CYP90A1/CPD, Coordinates the expression of hormone- and stress-related genes and genes related to cell wall modification and growth, leading to altered sugar-dependent growth and developmental responses, Component of the MAC complex that probably regulates defense responses through transcriptional control and thereby is essential for plant innate immunity, By suppressing the expression of several (1)O(2)-responsive genes, PRL1 seems to play a major role in modulating responses of plants to environmental changes by interconnecting (1)O(2)-mediated retrograde signaling with other signaling pathways, Acts as negative regulator of SNF1-related protein kinases AKIN10 and AKIN11 via the inhibition of their interaction with SKP1/ASK1, Component of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex, PRL1 may function as the substrate recognition module within this complex, leading to the AKIN10 degradation

Belongs to the WD repeat PRL1/PRL2 family


This is Amino acid permease 1 protein, from Mouse-ear cress, contains 485 amino acids, is membrane-bound, locates in Cell membrane.

Amino acid-proton symporter, Stereospecific transporter with a broad specificity for histidine, glutamate and neutral amino acids, Reduced affinities for asparagine and valine, Involved in amino acid uptake from the apoplastic cavity into the embryo cells for storage protein accumulation and in root amino acid uptake

Belongs to the amino acid/polyamine transporter 2 family, Amino acid/auxin permease (AAAP) (TC 2,A,18,2) subfamily


This is Thioredoxin H3 protein, from Mouse-ear cress, contains 118 amino acids, is soluble, locates in Cytoplasm.

Thiol-disulfide oxidoreductase that possesses disulfide reductase and insulin disulfide bonds reducing activities, Heat shock causes oligomerization and formation of high molecular weight (HMW) complexes with concomitant functional switching from a disulfide reductase to chaperone

Belongs to the thioredoxin family, Plant H-type subfamily


This is U1 small nuclear ribonucleoprotein 70 kDa protein, from Mouse-ear cress, contains 427 amino acids, is soluble, locates in Nucleus.

Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA


This is Calcium-dependent protein kinase 8 protein, from Mouse-ear cress, contains 533 amino acids, is membrane-bound, locates in Cell membrane.

May play a role in signal transduction pathways that involve calcium as a second messenger

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CDPK subfamily


This is Tryptophan synthase alpha chain, chloroplastic protein, from Mouse-ear cress, contains 312 amino acids, is soluble, locates in Plastid.

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate, Required for tryptophan biosynthesis, Contributes to the tryptophan-independent indole biosynthesis, and possibly to auxin production


This is Protochlorophyllide reductase A, chloroplastic protein, from Mouse-ear cress, contains 405 amino acids, locates in Plastid.

Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide), PORA may also function as a photoprotectant during the transitory stage from dark to light, Functions in skotomorphogenesis, photomorphogenesis and throughout the plant life under specific light conditions

Belongs to the short-chain dehydrogenases/reductases (SDR) family, POR subfamily


This is Protein-L-isoaspartate O-methyltransferase 1 protein, from Mouse-ear cress, contains 230 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues, It plays a role in the repair and/or degradation of damaged proteins, Contributes to seed longevity and germination vigor by limiting the abnormal accumulation of the L-isoaspartyl residues in seed proteins

Belongs to the methyltransferase superfamily, L-isoaspartyl/D-aspartyl protein methyltransferase family


This is L-ascorbate peroxidase 3 protein, from Mouse-ear cress, contains 287 amino acids, is membrane-bound, locates in Peroxisome.

Plays a key role in hydrogen peroxide removal

Belongs to the peroxidase family, Ascorbate peroxidase subfamily


This is Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1 protein, from Mouse-ear cress, contains 351 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the interconversion between UDP-glucose and UDP-galactose and the interconversion between UDP-arabinose and UDP-xylose (PubMed:8615692, PubMed:17496119), Plays a role in D-galactose detoxification

Belongs to the NAD(P)-dependent epimerase/dehydratase family


This is Ribulose-phosphate 3-epimerase, chloroplastic protein, from Spinach, contains 285 amino acids, is membrane-bound, locates in Plastid.

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate

Belongs to the ribulose-phosphate 3-epimerase family


This is Adenylyl-sulfate kinase 1, chloroplastic protein, from Mouse-ear cress, contains 276 amino acids, locates in Plastid.

Catalyzes the synthesis of activated sulfate, Essential for plant reproduction and viability, Required for the production of glucosinolates


This is Acid beta-fructofuranosidase 3, vacuolar protein, from Mouse-ear cress, contains 648 amino acids, locates in Lysosome/Vacuole.

Possible role in the continued mobilization of sucrose to sink organs

Belongs to the glycosyl hydrolase 32 family


This is Protein TOC75, chloroplastic protein, from Garden pea, contains 809 amino acids, is membrane-bound, locates in Plastid.

Mediates the insertion of proteins targeted to the outer membrane of chloroplasts, Required for the import of protein precursors into chloroplasts, Forms the voltage-dependent preprotein translocation channels (hydrophilic beta barrel) of the TOC complex in the chloroplastic outer membrane, The narrowest inner diameter of this channel is approximately 14 Angstroms


This is Leucine-rich repeat-containing protein 4 protein, from Rat, contains 652 amino acids, has 1 Ig-like C2-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like C2-type

Synaptic adhesion protein, Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins, Organize the lamina/pathway-specific differentiation of dendrites, Plays an important role for auditory synaptic responses, Involved in the suppression of glioma


This is T-cell immunoreceptor with Ig and ITIM domains protein, from Human, contains 244 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Cell membrane.

Ig-like V-type

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells


This is Cytokine-like nuclear factor N-PAC protein, from Human, contains 553 amino acids, locates in Nucleus.

Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244), Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:30970244, PubMed:29759984), Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244), Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:30970244, PubMed:29759984), Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984), With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466), Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664), Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664), The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664)

Belongs to the HIBADH-related family, NP60 subfamily


This is Coiled-coil domain-containing protein 14 protein, from Human, contains 953 amino acids, is soluble, locates in Cytoplasm.

Negatively regulates centriole duplication, Negatively regulates CEP63 and CDK2 centrosomal localization


This is Transcription termination factor 2, mitochondrial protein, from Human, contains 385 amino acids, is soluble, locates in Mitochondrion.

Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species


This is Microtubule-associated protein 9 protein, from Human, contains 647 amino acids, is soluble, locates in Cytoplasm.

Involved in organization of the bipolar mitotic spindle, Required for bipolar spindle assembly, mitosis progression and cytokinesis, May act by stabilizing interphase microtubules


This is Histone-lysine N-methyltransferase KMT5B protein, from Human, contains 885 amino acids, locates in Nucleus.

Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273), In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869), H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression, Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions, KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity), Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823), Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273), May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, Suvar4-20 subfamily


This is La-related protein 7 protein, from Human, contains 582 amino acids, is soluble, locates in Nucleus.

RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:18249148, PubMed:32017898), Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (PubMed:18249148, PubMed:18483487), The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:18249148, PubMed:18483487), The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838), LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (PubMed:18483487, PubMed:18281698), LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017898), Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017898), U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017898), Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (PubMed:32017898), U6 snRNA processing is required for spermatogenesis (By similarity)


This is NAD kinase 2, mitochondrial protein, from Human, contains 442 amino acids, locates in Mitochondrion.

Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+), Can use both ATP or inorganic polyphosphate as the phosphoryl donor, Also has weak NADH kinase activity in vitro; however NADH kinase activity is much weaker than the NAD(+) kinase activity and may not be relevant in vivo


This is Cilia- and flagella-associated protein 221 protein, from Human, contains 840 amino acids, is soluble, locates in Cytoplasm.


This is Malonate--CoA ligase ACSF3, mitochondrial protein, from Human, contains 576 amino acids, locates in Mitochondrion.

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed:21846720, PubMed:21841779), May have some preference toward very-long-chain substrates (PubMed:17762044)

Belongs to the ATP-dependent AMP-binding enzyme family


This is Peptidyl-prolyl cis-trans isomerase E protein, from Barber pole worm, contains 324 amino acids, locates in Nucleus.

PPIases accelerate the folding of proteins, It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, Combines RNA-binding and PPIase activities

Belongs to the cyclophilin-type PPIase family, PPIase E subfamily


This is Prolyl endopeptidase-like protein, from Human, contains 727 amino acids, is soluble, locates in Cytoplasm.

Serine peptidase whose precise substrate specificity remains unclear (PubMed:16143824, PubMed:16385448, PubMed:28726805), Does not cleave peptides after a arginine or lysine residue (PubMed:16143824), Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636), May play a role in the regulation of synaptic vesicle exocytosis (PubMed:24610330)


This is LHFPL tetraspan subfamily member 5 protein protein, from Mouse, contains 219 amino acids, is membrane-bound, locates in Cell membrane.

In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel, Regulates transducer channel conductance and is required for fast channel adaptation


This is TBC1 domain family member 10B protein, from Human, contains 808 amino acids, is soluble, locates in Cytoplasm.

Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35, Does not act on RAB2A and RAB6A


This is Anoctamin-6 protein, from Human, contains 910 amino acids, is membrane-bound, locates in Cell membrane.

(Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia


This is Folic acid synthesis protein fol1 protein, from Fission yeast, contains 733 amino acids, is soluble, locates in Cytoplasm.

Catalyzes three sequential steps of tetrahydrofolate biosynthesis

In the C-terminal section; belongs to the DHPS family


This is E3 SUMO-protein ligase nse2 protein, from Fission yeast, contains 250 amino acids, has 1 SP-RING-type Zinc finger, locates in Nucleus.

SP-RING-type

Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins, Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks, Plays a critical role in meiosis


This is Phospholipid--sterol O-acyltransferase protein, from Mouse-ear cress, contains 633 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Involved in lipid catabolism, Essential for sterol esters biosynthesis in leaves and seeds, but not in flowers, Plays a role in controlling the free sterol content of leaves, Catalyzes the transacylation of acyl groups from phospholipids to a variety of different sterols, Prefers phosphatidylethanolamine over phosphatidylcholine as an acyl donor, Not active toward neutral lipids, Highly specific for position sn-2, which in plant lipids is essentially devoid of saturated acyl groups, Broad sterol specificity (cholesterol > campesterol > sitosterol > stigmasterol), but no activity with lupeol or beta-amyrin

Belongs to the AB hydrolase superfamily, Lipase family


This is Protein LURE 1.2 protein, from Mouse-ear cress, contains 90 amino acids, is soluble, locates in Extracellular.

Pollen tube attractants guiding pollen tubes to the ovular micropyle (PubMed:23271953, PubMed:29109411), Attracts specifically pollen tubes from A,thaliana, but not those from A,lyrata (PubMed:23271953), Triggers endocytosis of MDIS1 in the pollen tube tip (PubMed:26863186)


This is Complement C1q-like protein 4 protein, from Mouse, contains 238 amino acids, is soluble, locates in Extracellular.

May regulate the number of excitatory synapses that are formed on hippocampus neurons, Has no effect on inhibitory synapses, May inhibit adipocyte differentiation at an early stage of the process


This is NADH kinase protein, from Mouse-ear cress, contains 317 amino acids, is soluble, locates in Cytoplasm.

Phosphorylates specifically NADH, Can phosphorylate NAD with a 100-fold decrease in efficiency compared to NADH, Prefers ATP as nucleoside triphosphate substrate, Can also utilize UTP, GTP and CTP, Key source of the cellular reductant NADPH which is an important antioxidant factor


This is Mini-chromosome maintenance complex-binding protein protein, from Mouse-ear cress, contains 589 amino acids, locates in Nucleus.

Associated component of the MCM complex that acts as a regulator of DNA replication, Binds to the MCM complex during late S phase and may act by promoting the disassembly of the MCM complex from chromatin, Required for sister chromatid cohesion