This is Lysosomal-associated transmembrane protein 5 protein, from Human, contains 262 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May have a special functional role during embryogenesis and in adult hematopoietic cells

Belongs to the LAPTM4/LAPTM5 transporter family


This is SNW domain-containing protein 1 protein, from Human, contains 536 amino acids, locates in Nucleus.

(Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters


This is Transformer-2 protein homolog alpha protein, from Human, contains 282 amino acids, locates in Nucleus.

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing

Belongs to the splicing factor SR family


This is Cullin-4B protein, from Human, contains 913 amino acids, locates in Nucleus.

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14578910, PubMed:16322693, PubMed:16678110, PubMed:18593899, PubMed:29779948, PubMed:30166453, PubMed:33854232, PubMed:33854239, PubMed:22118460), The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:29779948, PubMed:22118460), CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:14578910, PubMed:16678110, PubMed:18593899, PubMed:22118460), Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage (PubMed:14578910, PubMed:16678110, PubMed:18593899), Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication (PubMed:16678110), A number of DCX complexes (containing either TRPC4AP or DCAF12 as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948), The DCX(AMBRA1) complex is a master regulator of the transition from G1 to S cell phase by mediating ubiquitination of phosphorylated cyclin-D (CCND1, CCND2 and CCND3) (PubMed:33854232, PubMed:33854239), The DCX(AMBRA1) complex also acts as a regulator of Cul5-RING (CRL5) E3 ubiquitin-protein ligase complexes by mediating ubiquitination and degradation of Elongin-C (ELOC) component of CRL5 complexes (PubMed:30166453), Required for ubiquitination of cyclin E (CCNE1 or CCNE2), and consequently, normal G1 cell cycle progression (PubMed:16322693, PubMed:19801544), Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism (PubMed:18235224), Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8 (PubMed:18235224), With CUL4A, contributes to ribosome biogenesis (PubMed:26711351)


This is Trophoblast glycoprotein protein, from Human, contains 420 amino acids, is membrane-bound, locates in Cell membrane.

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization


This is THO complex subunit 5 homolog protein, from Human, contains 683 amino acids, locates in Cytoplasm.

Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate, May be involved in the differentiation of granulocytes and adipocytes, Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development


This is Phorbol-12-myristate-13-acetate-induced protein 1 protein, from Human, contains 54 amino acids, locates in Mitochondrion.

Promotes activation of caspases and apoptosis, Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria, Contributes to p53/TP53-dependent apoptosis after radiation exposure, Promotes proteasomal degradation of MCL1, Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity), Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1


This is ADP-ribosylation factor-related protein 1 protein, from Human, contains 201 amino acids, locates in Golgi apparatus.

Trans-Golgi-associated GTPase that regulates protein sorting, Controls the targeting of ARL1 and its effector to the trans-Golgi, Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver

Belongs to the small GTPase superfamily, Arf family


This is Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 protein, from Human, contains 863 amino acids, is soluble, locates in Extracellular.

Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:15769751, PubMed:26371182, PubMed:27754931, PubMed:14500380, PubMed:12354767), Major substrate is lysophosphatidylcholine (PubMed:12176993, PubMed:27754931, PubMed:14500380), Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility (PubMed:14500380), Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:15769751, PubMed:12176993), Involved in several motility-related processes such as angiogenesis and neurite outgrowth, Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation (PubMed:11559573), Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein (PubMed:1733949), May have a role in induction of parturition (PubMed:12176993), Possible involvement in cell proliferation and adipose tissue development (Probable), Tumor cell motility-stimulating factor (PubMed:1733949, PubMed:11559573), Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (PubMed:21393252), Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (PubMed:21393252)

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family


This is Nucleolar GTP-binding protein 2 protein, from Human, contains 731 amino acids, locates in Nucleus.

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547), May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195)

Belongs to the TRAFAC class YlqF/YawG GTPase family, NOG2 subfamily


This is Krueppel-like factor 9 protein, from Human, contains 244 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor that binds to GC box promoter elements, Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box, Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835)

Belongs to the Sp1 C2H2-type zinc-finger protein family


This is Krueppel-like factor 5 protein, from Human, contains 457 amino acids, has 3 C2H2-type Zinc finger, locates in Nucleus.

Transcription factor that binds to GC box promoter elements, Activates the transcription of these genes

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Protein CASP protein, from Human, contains 678 amino acids, is membrane-bound, locates in Golgi apparatus.

May be involved in intra-Golgi retrograde transport


This is Potassium voltage-gated channel subfamily C member 3 protein, from Human, contains 757 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons, The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient, The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792), It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells, Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity), Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792), Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484)

Belongs to the potassium channel family, C (Shaw) (TC 1,A,1,2) subfamily, Kv3,3/KCNC3 sub-subfamily


This is Bile acid-CoA:amino acid N-acyltransferase protein, from Human, contains 418 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12810727, PubMed:8034703, PubMed:2037576, PubMed:12239217), More than 95% of the BAs are N-acyl amidates with glycine and taurine (PubMed:8034703), Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (PubMed:12810727), This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption (PubMed:12810727), May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (PubMed:12810727, PubMed:8034703, PubMed:12239217), In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (PubMed:12810727)

Belongs to the C/M/P thioester hydrolase family


This is Lysosome membrane protein 2 protein, from Human, contains 478 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

(Microbial infection) Acts as a receptor for enterovirus 71


This is Vascular endothelial zinc finger 1 protein, from Human, contains 521 amino acids, has 6 C2H2-type Zinc finger, locates in Nucleus.

Possible transcription factor, Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3


This is Protein DGCR6 protein, from Human, contains 220 amino acids, locates in Nucleus.

May play a role in neural crest cell migration into the third and fourth pharyngeal pouches


This is Tripartite motif-containing protein 29 protein, from Human, contains 588 amino acids, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

B box-type

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract, Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation, In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited, Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation


This is Ribosome biogenesis protein BOP1 protein, from Human, contains 746 amino acids, is soluble, locates in Nucleus.

Component of the PeBoW complex, which is required for maturation of 28S and 5,8S ribosomal RNAs and formation of the 60S ribosome

Belongs to the WD repeat BOP1/ERB1 family


This is DAP3-binding cell death enhancer 1 protein, from Human, contains 515 amino acids, locates in Mitochondrion.

Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI (PubMed:32132706, PubMed:32132707), It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR (PubMed:32132706, PubMed:32132707)


This is DNA repair-scaffolding protein protein, from Human, contains 915 amino acids, locates in Nucleus.

Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR), Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity


This is Single-minded homolog 2 protein, from Human, contains 667 amino acids, locates in Nucleus.

Transcription factor that may be a master gene of CNS development in cooperation with Arnt, It may have pleiotropic effects in the tissues expressed during development


This is Dihydropyrimidinase-related protein 1 protein, from Human, contains 572 amino acids, is soluble, locates in Cytoplasm.

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:25358863), Plays a role in axon guidance (PubMed:25358863), During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863), Involved in invasive growth and cell migration (PubMed:11562390), May participate in cytokinesis (PubMed:19799413)

Belongs to the metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family


This is Adhesion G protein-coupled receptor E1 protein, from Human, contains 886 amino acids, is membrane-bound, locates in Cell membrane.

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system, May play a role in regulatory T-cells (Treg) development

Belongs to the G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily


This is Peptidyl-prolyl cis-trans isomerase FKBP8 protein, from Human, contains 412 amino acids, is membrane-bound, locates in Mitochondrion.

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium, Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state, The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets, The active form of FKBP8 may therefore play a role in the regulation of apoptosis, Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297)


This is Growth arrest-specific protein 6 protein, from Human, contains 678 amino acids, is soluble, locates in Extracellular.

(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828), Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921), Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828), Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688)


This is Chorionic somatomammotropin hormone-like 1 protein, from Human, contains 222 amino acids, is soluble, locates in Extracellular.

May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation

Belongs to the somatotropin/prolactin family


This is Polypeptide N-acetylgalactosaminyltransferase 3 protein, from Human, contains 633 amino acids, is membrane-bound, locates in Golgi apparatus.

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:8663203, PubMed:9295285, PubMed:16638743, PubMed:31932717), Has activity toward HIV envelope glycoprotein gp120, EA2, MUC2, MUC1A and MUC5AC (PubMed:8663203, PubMed:9295285), Probably glycosylates fibronectin in vivo (PubMed:9295285), Glycosylates FGF23 (PubMed:16638743, PubMed:31932717)

Belongs to the glycosyltransferase 2 family, GalNAc-T subfamily


This is Hyaluronan-binding protein 2 protein, from Human, contains 560 amino acids, is soluble, locates in Extracellular.

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly, It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form, Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080), May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560)


This is Hypermethylated in cancer 1 protein protein, from Human, contains 733 amino acids, has 5 C2H2-type Zinc finger, locates in Nucleus.

Transcriptional repressor (PubMed:12052894, PubMed:15231840), Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' (PubMed:15231840), May act as a tumor suppressor (PubMed:20154726), Involved in development of head, face, limbs and ventral body wall (By similarity), Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses (PubMed:16269335), The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1 (PubMed:12052894, PubMed:20547755), In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells (PubMed:20547755), Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes (PubMed:16724116), Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex (PubMed:18347096, PubMed:19486893), Probably represses transcription of ACKR3, FGFBP1 and EFNA1 (PubMed:16690027, PubMed:19525223, PubMed:20154726)

Belongs to the krueppel C2H2-type zinc-finger protein family, Hic subfamily


This is Interferon regulatory factor 3 protein, from Human, contains 427 amino acids, locates in Cytoplasm.

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:22394562, PubMed:25636800, PubMed:27302953, PubMed:24049179, PubMed:31340999), Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11846977, PubMed:16846591, PubMed:16979567, PubMed:20049431, PubMed:32972995), Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431), Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:22394562, PubMed:25636800, PubMed:27302953), This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16154084, PubMed:27302953, PubMed:33440148), Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591), In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis (PubMed:25609812), Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148)


This is EKC/KEOPS complex subunit LAGE3 protein, from Human, contains 143 amino acids, locates in Nucleus.

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914), The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914), LAGE3 functions as a dimerization module for the complex (PubMed:22912744, PubMed:27903914)


This is Ribosomal RNA processing protein 1 homolog B protein, from Human, contains 758 amino acids, locates in Nucleus.

(Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA


This is LRP chaperone MESD protein, from Human, contains 234 amino acids, locates in Endoplasmic reticulum.

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) (PubMed:15014448), Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane (PubMed:17488095), Essential for specification of embryonic polarity and mesoderm induction, Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity), May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity)


This is Raftlin protein, from Human, contains 578 amino acids, is membrane-bound, locates in Cell membrane.

Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579), Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579), Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity), May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216), May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216)


This is Chromobox protein homolog 2 protein, from Human, contains 532 amino acids, locates in Nucleus.

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530), PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530), Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity), Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity), Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780)


This is N-alpha-acetyltransferase 30 protein, from Human, contains 362 amino acids, is soluble, locates in Cytoplasm.

Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex, Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly, Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate

Belongs to the acetyltransferase family, MAK3 subfamily


This is Myocyte-specific enhancer factor 2D protein, from Human, contains 521 amino acids, locates in Nucleus.

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes, Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival, Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription, Plays a critical role in the regulation of neuronal apoptosis (By similarity)


This is Speriolin protein, from Mouse, contains 480 amino acids, is soluble, locates in Cytoplasm.


This is Nuclear receptor subfamily 1 group D member 2 protein, from Human, contains 579 amino acids, has 2 NR C4-type Zinc finger, locates in Nucleus.

NR C4-type

NR C4-type

Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner, Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1 and CLOCK, Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response, Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression, Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element, Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nuclegotides (RevDR-2), Acts as a potent competitive repressor of ROR alpha (RORA) function and also negatively regulates the expression of NR1D1, Regulates lipid and energy homeostasis in the skeletal muscle via repression of genes involved in lipid metabolism and myogenesis including: CD36, FABP3, FABP4, UCP3, SCD1 and MSTN, Regulates hepatic lipid metabolism via the repression of APOC3, Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs), In addition to its activity as a repressor, can also act as a transcriptional activator, Acts as a transcriptional activator of the sterol regulatory element-binding protein 1 (SREBF1) and the inflammatory mediator interleukin-6 (IL6) in the skeletal muscle (By similarity), Plays a role in the regulation of circadian sleep/wake cycle; essential for maintaining wakefulness during the dark phase or active period (By similarity), Key regulator of skeletal muscle mitochondrial function; negatively regulates the skeletal muscle expression of core clock genes and genes involved in mitochondrial biogenesis, fatty acid beta-oxidation and lipid metabolism (By similarity), May play a role in the circadian control of neutrophilic inflammation in the lung (By similarity)

Belongs to the nuclear hormone receptor family, NR1 subfamily


This is Rho GTPase-activating protein 19 protein, from Human, contains 494 amino acids, locates in Nucleus.

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state


This is FAST kinase domain-containing protein 3, mitochondrial protein, from Human, contains 662 amino acids, locates in Mitochondrion.

Required for normal mitochondrial respiration (PubMed:20869947), Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6, Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity (PubMed:27789713)


This is Glycerol-3-phosphate acyltransferase 2, mitochondrial protein, from Mouse, contains 801 amino acids, is membrane-bound, locates in Mitochondrion.

Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids (PubMed:17013544, PubMed:17689486, PubMed:22905194), In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA) (PubMed:22905194), Prefers arachidonoyl-CoA as the acyl donor (PubMed:22905194), Required for primary processing step during piRNA biosynthesis (PubMed:23611983), Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity (PubMed:23611983)


This is Pre-mRNA-splicing regulator WTAP protein, from Human, contains 396 amino acids, is soluble, locates in Nucleus.

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755), Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863), Acts as a mRNA splicing regulator (PubMed:12444081), Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532), Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724)


This is Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein protein, from Human, contains 391 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405), Could enhance presenilin-mediated amyloid-beta protein 40 generation, Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982)


This is Polycomb protein SUZ12 protein, from Human, contains 739 amino acids, has 1 C2H2-type Zinc finger, locates in Nucleus.

Polycomb group (PcG) protein, Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557), The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464), Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557)

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family


This is 116 kDa U5 small nuclear ribonucleoprotein component protein, from Human, contains 972 amino acids, locates in Nucleus.

Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154), Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661), As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily


This is Ribosome biogenesis regulatory protein homolog protein, from Human, contains 365 amino acids, locates in Nucleus.

Involved in ribosomal large subunit assembly, May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus


This is IQ calmodulin-binding motif-containing protein 1 protein, from Human, contains 598 amino acids, is soluble, locates in Cytoplasm.

Involved in ciliogenesis, The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637), Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos, May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655)


This is WD repeat-containing protein 43 protein, from Human, contains 677 amino acids, locates in Nucleus.

Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis (PubMed:17699751), Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome, Involved in nucleolar processing of pre-18S ribosomal RNA, Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751, PubMed:34516797), Essential for stem cell pluripotency and embryonic development, In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level expression of its targets genes (By similarity)


This is Zinc finger protein OZF protein, from Human, contains 292 amino acids, has 10 C2H2-type Zinc finger, locates in Nucleus.


This is [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial protein, from Human, contains 436 amino acids, is soluble, locates in Mitochondrion.

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2, This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate, Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia, Protects cells against apoptosis in response to hypoxia and oxidative stress

Belongs to the PDK/BCKDK protein kinase family


This is Phosphomevalonate kinase protein, from Human, contains 192 amino acids, locates in Peroxisome.

Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites


This is Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform protein, from Human, contains 497 amino acids, is soluble, locates in Cytoplasm.

As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation, The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation

Belongs to the phosphatase 2A regulatory subunit B56 family


This is Periodic tryptophan protein 2 homolog protein, from Human, contains 919 amino acids, locates in Nucleus.

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit, During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome


This is Retinoblastoma-binding protein 5 protein, from Human, contains 538 amino acids, locates in Nucleus.

In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity), Does not affect ES cell self-renewal (By similarity), Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338), As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245), Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245), In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120)


This is Ankyrin repeat domain-containing protein 1 protein, from Human, contains 319 amino acids, locates in Nucleus.

May play an important role in endothelial cell activation, May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes, Induction seems to be correlated with apoptotic cell death in hepatoma cells


This is Mitochondrial import receptor subunit TOM20 homolog protein, from Human, contains 145 amino acids, is membrane-bound, locates in Mitochondrion.

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins, Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity), Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases


This is Pumilio homolog 3 protein, from Human, contains 648 amino acids, is soluble, locates in Nucleus.

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351), Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524), Involved in development of the eye and of primordial germ cells (By similarity)


This is Scaffold attachment factor B1 protein, from Human, contains 915 amino acids, locates in Nucleus.

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816), Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241), Thereby acts as a negative regulator of cell proliferation (PubMed:12660241), When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity)


This is Telomeric repeat-binding factor 2 protein, from Human, contains 542 amino acids, locates in Nucleus.

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes, In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo, Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection, Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways, Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair, Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo, Preferentially binds to positive supercoiled DNA, Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology, Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length


This is Microtubule-associated protein RP/EB family member 2 protein, from Human, contains 327 amino acids, is soluble, locates in Cytoplasm.

May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes, May play a role in cell migration (By similarity)


This is Dixin protein, from Human, contains 683 amino acids, is soluble, locates in Cytoplasm.

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2, Regulates JNK activation by AXIN1 and DVL2


This is Thyroid receptor-interacting protein 6 protein, from Human, contains 476 amino acids, locates in Cytoplasm.

Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness, Involved in lysophosphatidic acid-induced cell adhesion and migration, Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor


This is U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 protein, from Human, contains 482 amino acids, has 2 C3H1-type Zinc finger, locates in Nucleus.

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns, Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing, Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes, For U2-type introns, it is selectively and specifically required for the second step of splicing


This is ALX homeobox protein 1 protein, from Human, contains 326 amino acids, locates in Nucleus.

Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334), Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures, Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171), May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509)


This is Tubulin-specific chaperone C protein, from Human, contains 346 amino acids, is soluble, locates in Cytoplasm.

Tubulin-folding protein; involved in the final step of the tubulin folding pathway


This is NEDD8 protein, from Human, contains 81 amino acids, locates in Nucleus.

Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:15242646, PubMed:14690597), Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (PubMed:9694792, PubMed:10318914, PubMed:10597293, PubMed:11953428, PubMed:20688984), Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity (PubMed:15242646), Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (PubMed:14690597)


This is Histone-lysine N-methyltransferase EZH2 protein, from Human, contains 746 amino acids, locates in Nucleus.

Polycomb group (PcG) protein, Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene, Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively, Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826), Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation, The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems, Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes, EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA, Regulates the circadian clock via histone methylation at the promoter of the circadian genes, Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, EZ subfamily


This is Zinc finger and BTB domain-containing protein 6 protein, from Human, contains 424 amino acids, has 4 C2H2-type Zinc finger, locates in Nucleus.

May be involved in transcriptional regulation


This is Transcription initiation factor TFIID subunit 12 protein, from Human, contains 161 amino acids, locates in Nucleus.

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473), TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473), The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473), Component of the TATA-binding protein-free TAF complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:7729427, PubMed:8598932, PubMed:8663456, PubMed:9674425, PubMed:9885574)


This is Hsp90 co-chaperone Cdc37 protein, from Human, contains 378 amino acids, is soluble, locates in Cytoplasm.

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233), Inhibits HSP90AA1 ATPase activity (PubMed:23569206)


This is U11/U12 small nuclear ribonucleoprotein 35 kDa protein protein, from Human, contains 246 amino acids, locates in Nucleus.


This is Mitogen-activated protein kinase kinase kinase 11 protein, from Human, contains 847 amino acids, is soluble, locates in Cytoplasm.

Activates the JUN N-terminal pathway, Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7, Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly, Influences microtubule organization during the cell cycle

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily


This is Transcription initiation factor TFIID subunit 9 protein, from Human, contains 264 amino acids, locates in Nucleus.

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473), TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473), The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473), TAF9 is also a component of the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex (PubMed:15899866), TAF9 and its paralog TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes (PubMed:15899866), Essential for cell viability (PubMed:15899866), May have a role in gene regulation associated with apoptosis (PubMed:15899866)


This is Neuronal regeneration-related protein protein, from Human, contains 68 amino acids, is soluble, locates in Cytoplasm.

May have roles in neural function, Ectopic expression augments motility of gliomas, Promotes also axonal regeneration (By similarity), May also have functions in cellular differentiation (By similarity), Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration, Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity), Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity), May play a role in the regulation of alveolar generation


This is Serotonin N-acetyltransferase protein, from Human, contains 207 amino acids, is soluble, locates in Cytoplasm.

Controls the night/day rhythm of melatonin production in the pineal gland, Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin

Belongs to the acetyltransferase family, AANAT subfamily


This is Cleavage and polyadenylation specificity factor subunit 6 protein, from Human, contains 551 amino acids, locates in Nucleus.

(Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro)


This is Zinc finger and SCAN domain-containing protein 26 protein, from Human, contains 478 amino acids, has 1 C2H2-type 1; degenerate Zinc finger, has 7 C2H2-type Zinc finger, locates in Nucleus.

C2H2-type 1; degenerate


This is Glutaminyl-peptide cyclotransferase protein, from Human, contains 361 amino acids, is soluble, locates in Extracellular.

Responsible for the biosynthesis of pyroglutamyl peptides, Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue, Also catalyzes N-terminal pyroglutamate formation, In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta, May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides

Belongs to the glutaminyl-peptide cyclotransferase family


This is Dual specificity protein phosphatase 6 protein, from Human, contains 381 amino acids, is soluble, locates in Cytoplasm.

Inactivates MAP kinases, Has a specificity for the ERK family (PubMed:9858808), Plays an important role in alleviating chronic postoperative pain, Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity), Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity), Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors (PubMed:29043977)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily


This is Discoidin domain-containing receptor 2 protein, from Human, contains 855 amino acids, is membrane-bound, locates in Cell membrane.

Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416), It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation, Required for normal bone development, Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2, Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion, Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing

Belongs to the protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily


This is UTP--glucose-1-phosphate uridylyltransferase protein, from Human, contains 508 amino acids, is soluble, locates in Cytoplasm.

UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen


This is Glutamate-gated chloride channel subunit beta protein, from Caenorhabditis elegans, contains 434 amino acids, is membrane-bound, locates in Cell membrane.

Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition, Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration, Channels containing only glc-2 are activated by glutamate, but not by ivermectin (in vitro), The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid (PubMed:7935817)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Glutamate-gated chloride channel (TC 1,A,9,4) subfamily


This is Pre-mRNA-splicing factor CWC22 homolog protein, from Caenorhabditis elegans, contains 897 amino acids, locates in Nucleus.

Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly, Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs, Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity), Plays a role in the nuclear retention of unspliced mRNAs (PubMed:23149939), Plays a role in sex determination (PubMed:23149939), Required for early embryogenesis and tissue differentiation


This is Defective pharyngeal development protein 4 protein, from Caenorhabditis elegans, contains 506 amino acids, locates in Nucleus.

Acts as a transcription factor required for formation of the pharyngeal primordium (PubMed:7607089, PubMed:18448117), Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression (PubMed:18448117), Becomes associated with pharyngeal target promoters by the 8E cell stage, playing a role in inducing large-scale chromatin decompaction, prior to the activation of transcription (PubMed:20714352), Binding with target sequences in pharyngeal cells may be repressed by the nuclear lamina protein emr-1 (PubMed:20714352), Activates a wide array of pharyngeal genes including ceh-22, pax-1 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate (PubMed:11823633, PubMed:20714352, PubMed:9584117, PubMed:14738885), Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development, Acts in the regulation of diet-restriction-mediated longevity by increasing expression of sod-1, sod-2, sod-4 and sod-5 but not sod-3 (PubMed:17476212), Positively regulates the expression of the transcription factor hlh-6 in the pharyngeal gland (PubMed:17049341), May regulate gene expression in the intestine (PubMed:18448117)


This is Kinetochore protein ndc-80 protein, from Caenorhabditis elegans, contains 590 amino acids, locates in Nucleus.

Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity (PubMed:14522947), Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores (PubMed:18765790, PubMed:19109417, PubMed:24231804), Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1 (PubMed:24231804), The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020)


This is WD repeat-containing protein wdr-5.1 protein, from Caenorhabditis elegans, contains 376 amino acids, locates in Nucleus.

Contributes to histone modification (PubMed:16710447, PubMed:17967446, PubMed:20188723, PubMed:20555324, PubMed:21455483, PubMed:22012258), May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:21455483), Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3 (PubMed:20555324, PubMed:21455483, PubMed:24682813, PubMed:21527717), Not required for demethylation of histone H3 'Lys-27' (PubMed:21455483), H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function (PubMed:21455483), Implicated in the epigenetic inheritance of lifespan over several generations (PubMed:22012258), Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids (PubMed:17967446, PubMed:20555324, PubMed:28379943), Required for RNA interference with probable antagonistic role against hpl-2 function (PubMed:17967446), Plays a role in vulval cell fate specification by acting in the synthetic multivulva pathway independent of set-2 (PubMed:17967446), Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development (PubMed:24682813), Acts with the sex determining factor tra-1, and redundantly with wdr-5,2, to regulate fog-3 expression, which in turn determines germ cell fate (PubMed:24682813), Cooperates with jmjd-3,1, egl-27 and unc-3 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development (PubMed:25124442)

Belongs to the WD repeat WDR5/wds family


This is Aspartyl aminopeptidase protein, from Caenorhabditis elegans, contains 470 amino acids, is soluble, locates in Cytoplasm.

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus, Plays a role in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo


This is Protein kinase C-like 3 protein, from Caenorhabditis elegans, contains 597 amino acids, has 1 Phorbol-ester/DAG-type Zinc finger, is soluble, locates in Cytoplasm.

Phorbol-ester/DAG-type

Required for the normal progression of embryogenesis and viability of the organism (PubMed:9422779), Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3 (PubMed:9716526, PubMed:9834192), Required for epithelial cell polarity in the distal spermatheca (PubMed:15151982), Phosphorylates serine residues of num-1 (PubMed:11134025), Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury (PubMed:19380113)

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily


This is Intermediate filament protein ifb-2 protein, from Caenorhabditis elegans, contains 543 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic intermediate filaments provide mechanical strength to cells, Not essential protein, Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells, Correct localization of filaments requires let-413

Belongs to the intermediate filament family


This is Inositol monophosphatase ttx-7 protein, from Caenorhabditis elegans, contains 285 amino acids, is soluble, locates in Cytoplasm.

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity), Required in central interneurons of the mature nervous system for correct localization of synaptic components, Required for thermotaxis

Belongs to the inositol monophosphatase superfamily


This is Pyruvate, phosphate dikinase regulatory protein, chloroplastic protein, from Maize, contains 426 amino acids, is soluble, locates in Plastid.

Bifunctional serine/threonine kinase and phosphorylase involved in the dark/light-mediated regulation of PPDK by catalyzing its phosphorylation/dephosphorylation, Dark/light-induced changes in stromal concentrations of the competing ADP and Pi substrates govern the direction of the reaction, In the dark, phosphorylates the catalytic intermediate of PPDK (PPDK-HisP), inactivating it, Light exposure induces the phosphorolysis reaction that reactivates PPDK, Phosphorylates PPDK at both Ser-528 and Thr-527 (PubMed:24710069), Can use ADP as a high specificity substrate and GDP as a lower affinity substrate, but has no activity with UDP (PubMed:21414960)

Belongs to the pyruvate, phosphate/water dikinase regulatory protein family, PDRP subfamily


This is T-box protein 2 protein, from Caenorhabditis elegans, contains 423 amino acids, locates in Nucleus.

Involved in the transcriptional regulation of genes required for the development of pharyngeal muscles derived from the ABa lineage (PubMed:16701625, PubMed:23933492), Acts as a transcriptional repressor and binds to T-box binding sites in its own promoter to negatively autoregulate its own expression in neurons, seam cells and the gut in order to restrict its expression to certain tissues (PubMed:25873636), May function together with the nfya-1-NF-Y complex to repress its own expression (PubMed:25873636), Plays a role in neural fate specification in the hermaphrodite-specific neuron (HSN)/PHB neuron lineage, acting in concert with homeobox protein egl-5 and the asymmetric cell division protein ham-1


This is Serine/threonine-protein kinase VRK1 protein, from Caenorhabditis elegans, contains 610 amino acids, locates in Nucleus.

Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation, May act through the egl-17 signaling pathway, Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line, Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation, Regulates anchor cell polarity and the timing of anchor cell invasion through the basement membranes separating vulval and somatic gonadal cells during the L3 larval stage

Belongs to the protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily


This is Transcription enhancer factor-like protein egl-44 protein, from Caenorhabditis elegans, contains 486 amino acids, locates in Nucleus.

Transcription factor (PubMed:30291162), Binds to DNA sequence motif 5'-CATNNNNAAATGCAT-3' as a heterodimer with egl-46 (PubMed:30291162), Represses expression of genes involved in differentiation of touch receptor neurons (TRN), probably acting as a heterodimer with egl-46, perhaps by occupying similar cis-regulatory elements as an unc-86/mec-3 heterodimer (PubMed:30291162), Plays a role in cell fate specification of neurons, including the hook neuron HOB, and touch receptor neurons (PubMed:12954713, PubMed:30291162), Involved in male mating behavior, acting in concert with egl-46, via modulation of expression of polycystins lov-1 and pkd-2, homeodomain protein ceh-26, and neuropeptide-like protein nlp-8 (PubMed:12954713), Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons (PubMed:11274062), Plays a role in neuron differentiation by repressing the expression of zag-1 in FLP neurons, probably acting as a heterodimer with egl-46; because zag-1 represses expression of egl-46 and egl-44, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates (PubMed:30291162), Also promotes HSN neuron development (PubMed:11274062), In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage (PubMed:23946438), Plays a role in specifying commissural dendrites of the PVD nociceptive neurons, acting in concert with egl-46 (PubMed:29031632), May be involved in thermal stress response downstream of yap-1 (PubMed:23396260)


This is Chromo domain-containing protein cec-4 protein, from Caenorhabditis elegans, contains 270 amino acids, is membrane-bound, locates in Nucleus.

Chromatin anchor protein which binds to methylated lysine residues on histone H3, thereby recruiting heterochromatin to the nuclear periphery, especially in embryonic cells, with a lesser role in differentiated cells (PubMed:26607792, PubMed:31118512), May be required for the correct positioning of chromatin and nucleoli in embryos (PubMed:26607792)


This is DNA dC->dU-editing enzyme APOBEC-3H protein, from Rhesus macaque, contains 210 amino acids, is soluble, locates in Cytoplasm.

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms, Exhibits antiviral activity against vif-deficient HIV-1, After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA, The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells, Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA

Belongs to the cytidine and deoxycytidylate deaminase family


This is Signal transducer and activator of transcription 3 protein, from Pig, contains 770 amino acids, locates in Cytoplasm.

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors, Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene, May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4, Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes, Activated by IL31 through IL31RA (By similarity), Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity), Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity), Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation, May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity), Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity), Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion, Plays an important role in host defense in methicillin-resistant S,aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity)

Belongs to the transcription factor STAT family


This is M-zodatoxin-Lt4b protein, from Spider, contains 179 amino acids, is soluble, locates in Extracellular.

Shows no antimicrobial activity against Gram-positive bacterium B,subtilis B-501 or Gram-negative bacterium E,coli DH5-alpha at concentration up to 20 uM

Belongs to the cationic peptide 03 (latarcin) family, 04 subfamily


This is M-zodatoxin-Lt4a protein, from Spider, contains 207 amino acids, is soluble, locates in Extracellular.

Shows no antimicrobial activity against Gram-positive bacterium B,subtilis B-501 or Gram-negative bacterium E,coli DH5-alpha at concentrations up to 20 uM, Shows no toxicity towards insect (S,carnaria) larvae


This is Folate synthesis bifunctional protein protein, from Mouse-ear cress, contains 484 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis (PubMed:17289662), Plays a role in seed stress response and survival (PubMed:17289662, PubMed:21996493)

In the C-terminal section; belongs to the DHPS family


This is Divinyl chlorophyllide a 8-vinyl-reductase, chloroplastic protein, from Mouse-ear cress, contains 417 amino acids, locates in Plastid.

Catalyzes the conversion of divinyl chlorophyllide to monovinyl chlorophyllide, Reduces the 8-vinyl group of the tetrapyrrole to an ethyl group using NADPH as the reductant, The best substrate is (3,8-divinyl)-chlorophyllide a (DV-Chlidea), Very low activity with (3,8-divinyl)-protochlorophyllide a (DV-Pchlidea) and (3,8-divinyl)-magnesium-protoporphyrin IX monomethyl ester (DV-MPE), No activity with (3,8-divinyl)-chlorophyllide b (DV-Chlideb), (3,8-divinyl)-magnesium-protoporphyrin IX (DV-Mg-Proto) and either (3,8-divinyl)-chlorophyll a (DV-Chla) or b (DV-Chlb)


This is ELAV-like protein 1-A protein, from African clawed frog, contains 337 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability, Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity), Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs, May be involved in cytoplasmic mRNA polyadenylation, Acts cooperatively with cribp to stabilize AU-rich sequence (ARE)-containing mRNAs, May play a role during gastrulation, Required for the vegetal localization of vg1 mRNA


This is Probable transmembrane GTPase FZO-like, chloroplastic protein, from Mouse-ear cress, contains 912 amino acids, is membrane-bound, locates in Plastid.

Probable membrane-remodeling GTPase that plays a unique role in the in the determination of thylakoid and chloroplast morphology and regulates organization of the thylakoid network, Not involved in the determination of mitochondrial morphology or ultrastructure

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family, Mitofusin subfamily


This is E3 ubiquitin-protein ligase brl1 protein, from Fission yeast, contains 692 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type

E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation


This is Kinesin-like protein tea2 protein, from Fission yeast, contains 628 amino acids, is soluble, locates in Cytoplasm.

Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell, Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively, ATPase activity stimulated via interaction with mal3

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family


This is Protein inscuteable homolog protein, from Human, contains 579 amino acids, is soluble, locates in Cytoplasm.

May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856), Involved in spindle orientation during mitosis, May regulate cell proliferation and differentiation in the developing nervous system, May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity)


This is ATP-dependent zinc metalloprotease FTSH 6, chloroplastic protein, from Mouse-ear cress, contains 688 amino acids, is membrane-bound, locates in Plastid.

Probable ATP-dependent zinc metallopeptidase, Involved in the degradation of the light-harvesting complex of photosystem II (LHC II) during senescence or high light acclimation

In the C-terminal section; belongs to the peptidase M41 family


This is Serine/threonine-protein kinase AGC1-7 protein, from Mouse-ear cress, contains 555 amino acids, is soluble, locates in Cytoplasm.

Functions redudantly with AGC1-5 as signaling component in the pollen tube, Required for polarized growth of pollen tubes

Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family


This is E3 ubiquitin-protein ligase TRIM71 protein, from Mouse, contains 855 amino acids, has 1 RING-type Zinc finger, has 1 B box-type 1; atypical Zinc finger, has 1 B box-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

B box-type 1; atypical

B box-type

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466), Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A, Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451), In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361), Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451), Specific regulator of miRNA biogenesis, miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity)


This is GATA-type zinc finger protein 1 protein, from Mouse, contains 266 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Transcriptional regulator that plays a key role in germ cell development (PubMed:16982049, PubMed:21123517, PubMed:32054698), Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry (PubMed:32054698), Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells (PubMed:32054698), Regulates expression of STRA8, a central downstream effector for the meiotic program (PubMed:32054698), Acts independently of retinoic acid (RA) (PubMed:32054698), In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase (PubMed:32054698)


This is Acid-sensing ion channel 1 protein, from Chicken, contains 527 amino acids, is membrane-bound, locates in Cell membrane.

Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized, Generates a biphasic current with a fast inactivating and a slow sustained phase, Has high selectivity for sodium ions and can also transport lithium ions with high efficiency, Can also transport potassium ions, but with lower efficiency, It is nearly impermeable to the larger rubidium and cesium ions

Belongs to the amiloride-sensitive sodium channel (TC 1,A,6) family, ASIC1 subfamily


This is MAP kinase kinase mkk-4 protein, from Caenorhabditis elegans, contains 363 amino acids, is soluble, locates in Cytoplasm.

Activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology (PubMed:15707898), Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983)

Belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily


This is Transcription factor cep-1 protein, from Caenorhabditis elegans, contains 644 amino acids, locates in Nucleus.

Transcriptional activator that binds the same DNA consensus sequence as p53 (PubMed:11696333, PubMed:15242600, PubMed:28560849), Has a role in normal development to ensure proper meiotic chromosome segregation (PubMed:11557844, PubMed:12445383), Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation (PubMed:11696333, PubMed:11557844, PubMed:12445383, PubMed:15273685, PubMed:17186023, PubMed:18836529, PubMed:21901106), Regulates germline apoptosis in response to DNA damage (PubMed:11696333, PubMed:15273685, PubMed:15707894, PubMed:16319925, PubMed:17276923, PubMed:17186023, PubMed:17347667, PubMed:19015549, PubMed:26598553), Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro (PubMed:12524540), Plays a role in cell cycle arrest in the germline in response to DNA damage by UV-C light (PubMed:17347667), However, not required for survival in response to DNA damage induced by UV-C light, indicating that it is unlikely to be involved in DNA repair (PubMed:17347667), Required for induction of ced-13 in response to DNA damage (PubMed:15605074), Regulates DNA damage-induced apoptosis by inducing transcription of the programmed cell death activator egl-1 (PubMed:12445383, PubMed:19521535), Regulates germline proliferation by activating phg-1 (PubMed:17186023), Modulates lifespan (PubMed:17895432, PubMed:18836529, PubMed:28560849)


This is Pumilio domain-containing protein 5 protein, from Caenorhabditis elegans, contains 553 amino acids, is soluble, locates in Cytoplasm.

RNA-binding protein that binds to the consensus sequence 5'-CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability, Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis


This is Metalloprotease mig-17 protein, from Caenorhabditis elegans, contains 509 amino acids, is soluble, locates in Extracellular.

Metalloprotease (PubMed:17491590, PubMed:18637819), Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis (PubMed:10864868, PubMed:15556863, PubMed:17491590, PubMed:19104038, PubMed:24318535, PubMed:26994289), Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane (PubMed:19104038), During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length (PubMed:26994289), Does not recruit fbl-1 to the pharynx basement membrane (PubMed:26994289)


This is Intermediate filament protein ifc-2 protein, from Caenorhabditis elegans, contains 622 amino acids, is soluble, locates in Cytoplasm.

Cytoplasmic intermediate filaments provide mechanical strength to cells, Not essential protein, although its absence leads to mild defects in locomotion


This is Peptide transporter family 1 protein, from Caenorhabditis elegans, contains 835 amino acids, is membrane-bound, locates in Cell membrane.

Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine, Transport is independent of sodium and chloride ions, Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine, Regulates cellular pH differences together with the antiporter protein, nhx-2, Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently affecting the stress response and longevity of the organism, It is required for the uptake of the L-enantiomers of various amino acids, including L-glutamate (PubMed:30560135), In response to the availability of amino acid nutrients, may play a role in promoting reproduction and fertility (PubMed:30560135)

Belongs to the major facilitator superfamily, Proton-dependent oligopeptide transporter (POT/PTR) (TC 2,A,17) family


This is Lamin-1 protein, from Caenorhabditis elegans, contains 566 amino acids, is membrane-bound, locates in Nucleus.

Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:11071918, PubMed:25057012), Provides a framework for the nuclear envelope and probably also interacts with chromatin (PubMed:11071918, PubMed:25057012), Essential to maintain the shape and integrity of the nucleus, and for DNA replication (PubMed:11071918), Involved in spatial organization of nuclear pore complexes (PubMed:11071918), It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C,elegans (PubMed:12064941)


This is Protein lin-14 protein, from Caenorhabditis elegans, contains 539 amino acids, locates in Nucleus.

May be involved in specifying L1 cell fates


This is MOG interacting and ectopic P-granules protein 1 protein, from Caenorhabditis elegans, contains 870 amino acids, has 6 C2H2-type Zinc finger, has 1 CCHC-type Zinc finger, locates in Nucleus.

CCHC-type

Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate, Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch, Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR


This is Nucleoside-diphosphatase mig-23 protein, from Caenorhabditis elegans, contains 552 amino acids, is membrane-bound, locates in Golgi apparatus.

Seems to be able to hydrolyze ADP, UDP and GDP, Supports mig-17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis


This is NAD-dependent protein deacetylase sir-2.1 protein, from Caenorhabditis elegans, contains 607 amino acids, locates in Nucleus.

NAD-dependent deacetylase (By similarity), Involved in metabolism, apoptosis, response to oxidative stress, response to DNA damage, and determination of lifespan (PubMed:16777605, PubMed:16280150, PubMed:16256736, PubMed:21909281, PubMed:23509272, PubMed:24077178, PubMed:27514077, PubMed:26598553, PubMed:27650246), Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites (PubMed:22393255), Plays a role in germ cell and somatic cell apoptosis in response to DNA damage (PubMed:26598553, PubMed:27650246), Functions upstream of daf-16/Forkhead box protein O in the Insulin/IGF-1-like signaling (IIS) mediated pathway, promoting daf-16 mediated transcriptional activation and increased lifespan (PubMed:16777605, PubMed:16280150), May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticulum (ER) (PubMed:16256736, PubMed:16280150), Functions upstream of transcriptional coregulator hcf-1, perhaps acting independently of the IIS mediated pathway, to modulate lifespan and oxidative stress response (PubMed:21909281), Acts upstream of the nicotinic acid metabolism pathway, which may be linked to the regulation of longevity (PubMed:24077178), Plays a role in ascaroside-mediated longevity and stress resistance (PubMed:23509272)

Belongs to the sirtuin family, Class I subfamily


This is L-xylulose reductase protein, from Caenorhabditis elegans, contains 251 amino acids, is membrane-bound, locates in Cell membrane.

Catalyzes the NADPH-dependent reduction of L-xylulose, D-xylulose, L-(+) erythrulose, D-erythrose, D-threose, L-ribulose, 1,4-dibromo-2,3-butanedione and 2,3-heptanedione (PubMed:21477590), Also active against isatin, 9,10-phenanthrenequinone, menadione, 2,3-hexaenadione and 3,4-hexahenadione (PubMed:21300042), No activity observed when tested using NADH rather than NADPH (PubMed:21300042)

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Cyclin-dependent kinase inhibitor 1 protein, from Caenorhabditis elegans, contains 184 amino acids, locates in Nucleus.

Negative cell-cycle regulator that functions at the G1-to-S-phase transition (PubMed:10587644, PubMed:9716524), Required for suspension of the cell cycle in dauer larvae and starved L1 larvae (PubMed:10587644, PubMed:9716524), In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage (PubMed:10587644, PubMed:9716524, PubMed:15247923), Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation (PubMed:10587644), Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1,aa/Z4,pp and in Z1,ap/Z4,pa (PubMed:17476329)


This is DNA-dependent metalloprotease dvc-1 protein, from Caenorhabditis elegans, contains 368 amino acids, has 1 UBZ4-type Zinc finger, locates in Nucleus.

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity (PubMed:27871365), DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde (PubMed:27871365), Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis (PubMed:27871365), Regulator of UV-induced DNA damage response: required to protect genome stability during DNA replication, possibly via recruitment of vcp/p97 (cdc-48,1 or cdc-48,2) recruitment (PubMed:23042605)


This is Histone-lysine N-methyltransferase set-1 protein, from Caenorhabditis elegans, contains 242 amino acids, locates in Nucleus.

Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1) (PubMed:23028348), H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis (PubMed:23028348, PubMed:22393255), Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites (PubMed:23028348), Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway (PubMed:23884442)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, PR/SET subfamily


This is Acetylcholine receptor subunit alpha-type unc-38 protein, from Caenorhabditis elegans, contains 511 amino acids, is membrane-bound, locates in Cell membrane.

Alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:9221782, PubMed:15990870, PubMed:20027209), Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion (PubMed:20027209), Involved in nAChR sensitivity to nicotine (PubMed:9221782, PubMed:15990870)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Acetylcholine receptor (TC 1,A,9,1) subfamily


This is Transcription factor egl-13 protein, from Caenorhabditis elegans, contains 470 amino acids, locates in Nucleus.

Probable transcription factor that is required for uterine and neuronal cell fate decisions (PubMed:9834196, PubMed:14668410, PubMed:23946438), Controls genes required for the specification and differentiation of O(2) and CO(2)-sensing neurons and for maintaining URX sensory neuronal cell fate (PubMed:23671427)


This is Small RNA 2'-O-methyltransferase protein, from Tetrahymena thermophila (strain SB210), contains 423 amino acids, locates in Nucleus.

Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements, This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation, Required for programmed DNA elimination

Belongs to the methyltransferase superfamily, HEN1 family


This is Probable splicing factor, arginine/serine-rich 2 protein, from Caenorhabditis elegans, contains 281 amino acids, locates in Nucleus.

Plays a functionally redundant role in spermatogenesis and growth rate control, Required for the development of somatic gonad structures and for progression from larval stage to adulthood

Belongs to the splicing factor SR family


This is Probable splicing factor, arginine/serine-rich 1 protein, from Caenorhabditis elegans, contains 312 amino acids, locates in Nucleus.

Plays a functionally redundant role in spermatogenesis and growth rate control


This is XO lethal protein 1 protein, from Caenorhabditis elegans, contains 417 amino acids, locates in Nucleus.

Sex-determining factor that is required for sexual differentiation and X chromosome dosage compensation to promote male development (PubMed:7813020, PubMed:9217163, PubMed:33372658), High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development, Although related to GHMP kinase, its mode of action remains unclear

Belongs to the GHMP kinase family, Xol-1 subfamily


This is Cytoplasmic aconitate hydratase protein, from Caenorhabditis elegans, contains 887 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (PubMed:12438312), Has probably no RNA-binding activity (PubMed:12438312)

Belongs to the aconitase/IPM isomerase family


This is Protein Smaug protein, from Fruit fly, contains 999 amino acids, is soluble, locates in Cytoplasm.

Translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevents their translation, Prevents translation of unlocalized nos in the bulk cytoplasm via the recruitment of cup


This is Protein matrimony protein, from Fruit fly, contains 217 amino acids, locates in Nucleus.

Polo kinase inhibitor required to maintain G2 arrest in the meiotic cell cycle in females (PubMed:18052611), Holds heterochromatically paired homologs together from the end of pachytene until metaphase I (PubMed:14573476), Haploinsufficient locus for homologous achiasmate segregation and may be required for the maintenance of heterochromatic pairings (PubMed:14573476)


This is Protein deltex protein, from Fruit fly, contains 738 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations, Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context, Mediates the antineural activity of Notch, May function as a ubiquitin ligase protein in the Notch pathway


This is Imaginal disk growth factor 6 protein, from Fruit fly, contains 452 amino acids, is soluble, locates in Extracellular.

Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells, May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity)

Belongs to the glycosyl hydrolase 18 family, IDGF subfamily


This is Inactivation-no-after-potential D protein protein, from Fruit fly, contains 674 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the negative feedback regulation of the light-activated signaling cascade in photoreceptors through a calcium-mediated process, Interacts with tetrapeptide ligand located in C-terminal sequence of 3 key components of the visual cascade, tethering them and forming a macromolecular signaling phototransduction complex


This is Dynein light chain 1, cytoplasmic protein, from Fruit fly, contains 89 amino acids, is soluble, locates in Cytoplasm.

Acts as a non-catalytic accessory component of a dynein complex

Belongs to the dynein light chain family


This is Negative elongation factor D protein, from Fruit fly, contains 578 amino acids, locates in Nucleus.

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II, The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing


This is Tyrosine-protein kinase Shark protein, from Fruit fly, contains 939 amino acids, is soluble, locates in Cytoplasm.

Following axon injury, required for recruitment of drpr and glial cells to severed axons and for glial clearance of severed axons from the central nervous system (PubMed:18432193), Together with Src42a and drpr, promotes the migration of macrophages to sites of wounding as part of a signaling cascade where Scr42a detects production of hydrogen peroxide at wound sites which triggers phosphorylation of drpr and subsequent recruitment and activation of shark (PubMed:26028435), May be involved in signal transduction on the apical surface of ectodermal epithelial cells, regulating their polarity during invagination (PubMed:7892198), Crumbs (crb) may be the intracellular signal (PubMed:7892198)

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is Origin recognition complex subunit 2 protein, from Fruit fly, contains 618 amino acids, locates in Nucleus.

Component of the origin recognition complex (ORC) that binds origins of replication (PubMed:11137005), DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far (PubMed:11137005), ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (PubMed:11137005), As part of the ORC complex, might also have a role in mRNA export (Probable)


This is Peripheral plasma membrane protein CASK protein, from Fruit fly, contains 898 amino acids, is membrane-bound, locates in Cell membrane.

May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides, Functionally modulates eag potassium channels; increases eag current and whole-cell conductance, Also regulates autophosphorylation of CaMKII


This is Cullin homolog 1 protein, from Fruit fly, contains 774 amino acids, is soluble, locates in Cytoplasm.

Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription, In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits, May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme, During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larval ddaC dendrites and mushroom body axons (PubMed:24068890), The SCF-slmb complex also regulates asymmetrical division of neuroblasts and inhibits ectopic neuroblast formation partly through SAK and Akt1 (PubMed:24413555), Also part of an SCF complex required for caspase activation during sperm differentiation (PubMed:20392747), Necessary for auditory transduction: plays a role in Johnston's organ organization by acting in the regulation of zip and ck function in scolopidial apical attachment (PubMed:27331610), May function by acting in a Ubr3-mediated pathway that negatively regulates the ubiquitination of zip, consequently affecting its interaction with ck (PubMed:27331610)


This is DNA-binding protein Ewg protein, from Fruit fly, contains 733 amino acids, locates in Nucleus.

May function as a positive regulator of transcription in developing and differentiated neurons, regulating common aspects of neuronal differentiation and maintenance, Requirement in the CNS may be higher than in the peripheral system, Vital for development of the indirect flight muscles