This is Alpha-1,3-galactosyltransferase 2 protein, from Rat, contains 339 amino acids, is membrane-bound, locates in Golgi apparatus.

Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide, Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures, Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids, Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids

Belongs to the glycosyltransferase 6 family


This is Protein LSM14 homolog A-A protein, from African clawed frog, contains 471 amino acids, is soluble, locates in Cytoplasm.

RNA-binding component of messenger ribonucleoprotein complexes (mRNPs), storage particles that mask maternal mRNAs from the translational apparatus during oocyte maturation (PubMed:17074753), Acts as a repressor of mRNA translation (PubMed:17074753), Probably involved in the storage of translationally inactive mRNAs in the cytoplasm in order to prevent their degradation (PubMed:17074753)


This is BICD family-like cargo adapter 1 protein, from Mouse, contains 577 amino acids, is soluble, locates in Cytoplasm.

Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin, Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track), Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor (PubMed:29420470, PubMed:33734450, PubMed:36071160), Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth, Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis


This is Zinc finger protein 382 protein, from Rat, contains 549 amino acids, has 10 C2H2-type Zinc finger, locates in Nucleus.

Functions as a sequence-specific transcriptional repressor

Belongs to the krueppel C2H2-type zinc-finger protein family


This is Sodium/mannose cotransporter SLC5A10 protein, from Human, contains 596 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the sodium:solute symporter (SSF) (TC 2,A,21) family


This is Irditoxin subunit A protein, from Brown tree snake, contains 109 amino acids, is soluble, locates in Extracellular.

This bird and reptile-specific postsynaptic neurotoxin inhibits the chick muscle alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHNRD) nicotinic acetylcholine receptor (nAChR) 100-fold more compared with the mouse receptor, In vivo, produces rapid flaccid paralysis, dyspnea and increased respiratory rate in geckos, At sublethal doses geckos were immobilized for up to three days and then recovered, Chicks injected with lethal doses showed rapid onset of inactivity, dyspnea and neck droop, and no extended paralysis with survival was seen

Belongs to the snake three-finger toxin family, Ancestral subfamily, Boigatoxin sub-subfamily


This is Irditoxin subunit B protein, from Brown tree snake, contains 111 amino acids, is soluble, locates in Extracellular.

This bird and reptile-specific postsynaptic neurotoxin inhibits the chick muscle alpha-1-beta-1-gamma-delta (CHRNA1-CHRNB1-CHRNG-CHRND) nicotinic acetylcholine receptor (nAChR) 100-fold more compared with the mouse receptor, In vivo, produces rapid flaccid paralysis, dyspnea and increased respiratory rate in geckos, At sublethal doses geckos were immobilized for up to three days and then recovered, Chicks injected with lethal doses showed rapid onset of inactivity, dyspnea and neck droop, and no extended paralysis with survival was seen


This is Protein FAM170A protein, from Human, contains 330 amino acids, has 1 C2H2-type; degenerate Zinc finger, locates in Nucleus.

C2H2-type; degenerate

Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes, Binds to heat shock promoter elements (HSE)


This is Anoctamin-9 protein, from Human, contains 782 amino acids, is membrane-bound, locates in Cell membrane.

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity), Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22178883), Can inhibit the activity of ANO1 (PubMed:20056604, PubMed:22946059)


This is Ubiquitin-conjugating enzyme E2Q-like protein 1 protein, from Human, contains 161 amino acids, locates in Nucleus.

Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins, May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7

Belongs to the ubiquitin-conjugating enzyme family


This is Nuclear envelope integral membrane protein 1b protein, from African clawed frog, contains 434 amino acids, is membrane-bound, locates in Nucleus.

In concert with ran, required for proper eye development (PubMed:25946333), May be involved in the expression of early eye marker genes (PubMed:19167377), Contributes to nuclear envelope stiffness in germ cells (By similarity), Required for fertility (By similarity)


This is Elongation of very long chain fatty acids protein 7 protein, from Human, contains 281 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle, This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle, Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs, Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA, Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs, May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators

Belongs to the ELO family, ELOVL7 subfamily


This is Transmembrane O-methyltransferase homolog protein, from Mouse, contains 258 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (PubMed:18794526), Required for auditory function (PubMed:18794526, PubMed:28504928), Component of the cochlear hair cell's mechanotransduction (MET) machinery, Involved in the assembly of the asymmetric tip-link MET complex, Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells, The function in MET is independent of the enzymatic activity (PubMed:28504928)

Belongs to the class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family


This is Transcription factor TCP18 protein, from Mouse-ear cress, contains 433 amino acids, locates in Nucleus.

Transcription factor that prevents axillary bud outgrowth and delays early axillary bud development, Indirectly required for the auxin-induced control of apical dominance


This is Facilitated trehalose transporter Tret1-1 protein, from Fruit fly, contains 857 amino acids, is membrane-bound, locates in Cell membrane.

Low-capacity facilitative transporter for trehalose, Does not transport maltose, sucrose or lactose, Mediates the bidirectional transfer of trehalose, Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph

Belongs to the major facilitator superfamily, Sugar transporter (TC 2,A,1,1) family, Trehalose transporter subfamily


This is Meiosis-specific coiled-coil domain-containing protein MEIOC protein, from Mouse, contains 965 amino acids, is soluble, locates in Cytoplasm.

Is required for meiosis completion in both male and female germ cells, Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I, The function may involve YTHDC2 and is independent of induction by retinoic acid (RA), Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle (PubMed:28380054)


This is Epididymal-specific lipocalin-5 protein, from Mouse, contains 192 amino acids, is soluble, locates in Extracellular.

Associates with spermatozoa in the epididymal fluid but does not bind tightly to them, Binds both all-trans and 13-cis retinoic acid, May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation

Belongs to the calycin superfamily, Lipocalin family


This is Acyl-coenzyme A amino acid N-acyltransferase 1 protein, from Mouse, contains 416 amino acids, locates in Peroxisome.

Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine (PubMed:17116739), Shows no conjugation activity in the presence of glycine (PubMed:17116739)

Belongs to the C/M/P thioester hydrolase family


This is Protein AF-9 protein, from Mouse, contains 569 amino acids, locates in Nucleus.

Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA, Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated, Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors, Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr), Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively), but with lower affinity than crotonylated histone H3, In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones, Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me), Plays a key role in hematopoietic stem cell (HSC) maintenance by preserving, rather than confering, HSC stemness, Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L


This is Leucine-rich repeat-containing G-protein coupled receptor 4 protein, from Mouse, contains 951 amino acids, is membrane-bound, locates in Cell membrane.

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs, Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes, In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal, Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye, May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo, Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells, Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts, Acts as a regulator of bone formation and remodeling, Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state, Involved in the development of the anterior segment of the eye, Required during erythropoiesis, Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production, Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (PubMed:24353284), Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (PubMed:32493844)

Belongs to the G-protein coupled receptor 1 family


This is Double-strand-break repair protein rad21-like protein 1 protein, from Mouse, contains 552 amino acids, locates in Nucleus.

Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis, Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes, Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I, Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I, Not required for meiosis in females in young mice, while it is required later as mice age


This is Short-chain dehydrogenase TIC 32, chloroplastic protein, from Mouse-ear cress, contains 322 amino acids, is membrane-bound, locates in Plastid.

Involved in protein precursor import into chloroplasts, Part of the redox regulon consisting of TIC32, TIC 55 and TIC62

Belongs to the short-chain dehydrogenases/reductases (SDR) family


This is Phospholipase A1 protein, from Neotropical social wasp, contains 322 amino acids, is soluble, locates in Extracellular.

Catalyzes the hydrolysis of phosphatidylcholine with phospholipase A1 activity (PubMed:17761205), Shows hemolytic activity (PubMed:17761205), Acts as an allergen (PubMed:17761205)

Belongs to the AB hydrolase superfamily, Lipase family


This is Sodium-coupled neutral amino acid transporter 5 protein, from Rat, contains 479 amino acids, is membrane-bound, locates in Cell membrane.

Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11698233, PubMed:16629640, PubMed:15218073, PubMed:22821889, PubMed:16249471), Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-glutamine cycle and the NMDA receptors activation (PubMed:22821889), In addition contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells and, therefore participates in the retinal glutamate-glutamine cycle (PubMed:16249471), The transport activity is pH sensitive (PubMed:22821889, PubMed:15218073, PubMed:11698233), Li(+) tolerant (PubMed:22821889, PubMed:15218073, PubMed:11698233), bidirectional (PubMed:22821889, PubMed:15218073) and associated with large uncoupled fluxes of protons (PubMed:22821889, PubMed:15218073, PubMed:11698233), The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (PubMed:22821889), May have particular importance for modulation of net hepatic glutamine flux (PubMed:15218073)

Belongs to the amino acid/polyamine transporter 2 family


This is GTP-binding protein 10 protein, from Human, contains 387 amino acids, locates in Nucleus.

May be involved in the ribosome maturation process, Complements an ObgE(CgtA) function in E,coli ribosome maturation, Plays a role of GTPase in vitro, When missing, disorganization of the nucleolar architecture is observed

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family


This is PIN2/TERF1-interacting telomerase inhibitor 1 protein, from Rat, contains 331 amino acids, locates in Nucleus.

Microtubule-binding protein essential for faithful chromosome segregation, Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres, Inhibits telomerase activity, May inhibit cell proliferation and act as tumor suppressor (By similarity)


This is Wee1-like protein kinase 2 protein, from Pig, contains 565 amino acids, locates in Nucleus.

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II, Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry, Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily


This is Catalase-peroxidase 2 protein, from Rice blast fungus, contains 786 amino acids, is soluble, locates in Extracellular.

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity, Confers resistance to H(2)O(2) in hyphae, May play an antioxidative role in fungal defense against the host-produced H(2)O(2) (oxidative burst) at the early stage of plant infection

Belongs to the peroxidase family, Peroxidase/catalase subfamily


This is Extracellular serine/threonine protein CG31145 protein, from Fruit fly, contains 528 amino acids, is membrane-bound, locates in Golgi apparatus.

Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs


This is Lactoperoxidase protein, from Domestic water buffalo, contains 712 amino acids, is soluble, locates in Extracellular.

Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (Probable), Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity), Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:12071645), Shows antibacterial properties against E,coli, K,pneumoniae, P,aeruginosa, S,sonnei, S,saphrophyticus, S,epidermidis and S,dysenteriae (PubMed:12071645), May protect the udder from infection and may promote growth in newborns (By similarity), May be implicated in airway host defense against infection (By similarity), May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity)

Belongs to the peroxidase family, XPO subfamily


This is Plasmanylethanolamine desaturase 1 protein, from Human, contains 270 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane (PubMed:31604315, PubMed:32209662), Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms (PubMed:31604315)

Belongs to the fatty acid desaturase CarF family


This is 5-hydroxytryptamine receptor 3E protein, from Human, contains 456 amino acids, is membrane-bound, locates in Cell membrane.

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen, This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses, It is a cation-specific, but otherwise relatively nonselective, ion channel

Belongs to the ligand-gated ion channel (TC 1,A,9) family, 5-hydroxytryptamine receptor (TC 1,A,9,2) subfamily, HTR3E sub-subfamily


This is SAC3 domain-containing protein 1 protein, from Mouse, contains 427 amino acids, is soluble, locates in Cytoplasm.

Involved in centrosome duplication and mitotic progression


This is Metalloprotease TIKI2 protein, from Human, contains 517 amino acids, is membrane-bound, locates in Cell membrane.

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins, Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation, Able to cleave WNT3A, WNT5, but not WNT11, Required for head formation


This is Ras association domain-containing protein 10 protein, from Human, contains 507 amino acids, is soluble, locates in Cytoplasm.

Plays an important role in regulating embryonic neurogenesis


This is Cannabidiolic acid synthase protein, from Hemp, contains 544 amino acids, is soluble, locates in Extracellular.

Oxidoreductase involved in the biosynthesis of cannabinoids-related terpenophenolic natural products, which have pharmacological activity (PubMed:17544411, PubMed:8663284), Catalyzes the stereoselective oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA), producing cannabidiolate (CBDA), the major cannabioid in fiber-type Cannabis plants (PubMed:17544411, PubMed:8663284), Can also use cannabinerolic acid as substrate, but not cannabigerol or cannabinerol (PubMed:17544411, PubMed:8663284)

Belongs to the oxygen-dependent FAD-linked oxidoreductase family


This is Renalase protein, from Mouse, contains 342 amino acids, is soluble, locates in Extracellular.

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+), The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure, Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk, High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis


This is Beta-hexosaminidase 1 protein, from Mouse-ear cress, contains 541 amino acids, locates in Lysosome/Vacuole.

Has a broad substrate specificity, Can use synthetic substrates such as pyridylaminated chitotriose, pyridylaminated chitobiose, p-nitrophenyl-beta-N-acetylglucosaminide, p-nitrophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside (pNP-GlcNAc), p-nitrophenyl-2-acetamido-2-deoxy-beta-D-galactopyranoside (pNP-GalNAc), 4-methylumbelliferyl-2-acetamido-2-deoxy-beta-D-glucopyranoside (MU-GlcNAc), and 4-methylumbelliferyl-6-sulfo-2-acetamido-2-deoxy-beta-D-glucopyranoside (MU-GlcNAc-6SO(4)) as substrates, Removes terminal GlcNAc residues from alpha1,3- and alpha1,6-mannosyl branches of biantennary N-glycans without any strict branch preference, Required for the presence of paucimannosidic N-glycans in glycoproteins of roots and, to a lower extent, of leaves

Belongs to the glycosyl hydrolase 20 family


This is Hydroxyproline O-galactosyltransferase GALT2 protein, from Mouse-ear cress, contains 684 amino acids, is membrane-bound, locates in Golgi apparatus.

Possesses hydroxyproline O-galactosyltransferase activity, Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs), Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues, Utilizes UDP-galactose solely as sugar donor, The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition, AGP glycans play essential roles in both vegetative and reproductive plant growth

Belongs to the glycosyltransferase 31 family


This is PBAN-type neuropeptides protein, from Honeybee, contains 195 amino acids, is soluble, locates in Extracellular.

A hormone that controls sex pheromone production in females and pheromone responsiveness in male, Also mediates visceral muscle contractile activity (myotropic activity) (By similarity)


This is POU class 2 homeobox associating factor 3 protein, from Human, contains 251 amino acids, is soluble, locates in Cytoplasm.

Transcriptional coactivator that specifically associates with POU2F3 (PubMed:35576971), This complex drives the development of tuft cells, a rare a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971)


This is Transcription factor kayak, isoforms D/sro protein, from Fruit fly, contains 722 amino acids, locates in Nucleus.

Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3', May play a role in the function or determination of a particular subset of cells in the developing embryo, It is able to carry out its function either independently of or in conjunction with Jra

Belongs to the bZIP family, Fos subfamily


This is Protein LNK1 protein, from Mouse-ear cress, contains 616 amino acids, locates in Nucleus.

Transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 (PubMed:25012192, PubMed:25848708), Antagonizes REV8 function in the regulation of anthocyanin accumulation (PubMed:25848001), Involved in red light input to the clock (PubMed:25012192), Activates clock-controlled genes with afternoon peak (PubMed:23818596), Mediates light inhibition of hypocotyl elongation (PubMed:23818596)


This is NAC domain-containing protein 68 protein, from Mouse-ear cress, contains 473 amino acids, is membrane-bound, locates in Nucleus.

Transcription activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) mediated by calpain or its functional homolog, Regulates cytokinin signaling during cell division


This is Dihydrolipoyl dehydrogenase 1, chloroplastic protein, from Mouse-ear cress, contains 623 amino acids, is soluble, locates in Plastid.

Lipoamide dehydrogenase is a component of the plastidial pyruvate dehydrogenase complex (PDC)

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family


This is Guanine nucleotide-binding protein G(t) subunit alpha-3 protein, from Human, contains 354 amino acids, is soluble, locates in Cytoplasm.

Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction, Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter, Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody, Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium, GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors, Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP, Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity

Belongs to the G-alpha family, G(i/o/t/z) subfamily


This is Chitin elicitor receptor kinase 1 protein, from Mouse-ear cress, contains 617 amino acids, is membrane-bound, locates in Cell membrane.

Lysin motif (LysM) receptor kinase that functions as a cell surface receptor in chitin elicitor (chitooligosaccharides) signaling leading to innate immunity toward both biotic and abiotic stresses (e,g, tolerance to salinity, heavy-metal stresses, and Botrytis cinerea infection), Recognizes microbe-derived N-acetylglucosamine (NAG)-containing ligands, Involved in the resistance to pathogenic fungi Alternaria brassicicola and Erysiphe cichoracearum, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP), Plays an essential role in detecting peptidoglycans (e,g, PGNs) and restricting bacterial growth, Target of the bacterial type III effector E3-ligase protein hopAB2/avrPtoB of Pseudomonas syringae pv, tomato DC3000 that mediates ubiquitination and subsequent proteolysis, thus blocking all defense responses by suppressing PAMP-triggered immunity (PTI), Mediates chitin-induced phosphorylation of PBL27 (PubMed:24750441)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Cilia- and flagella-associated protein 221 protein, from Mouse, contains 836 amino acids, is soluble, locates in Cytoplasm.


This is Importin subunit alpha-8 protein, from Human, contains 516 amino acids, locates in Nucleus.


This is Tabersonine 16-O-methyltransferase protein, from Madagascar periwinkle, contains 355 amino acids, is soluble, locates in Cytoplasm.

16-O-methyltransferase involved in the biosynthesis of vindoline, Highly specific for 16-hydroxytabersonine, No activity with tabersonine, 3-hydroxytyramine, 4-hydroxytyramine, 5-hydroxytryptamine (5HT), 2,3-dihydro-3-hydroxytabersonine, lochnericine, hoerhammericine, 16-hydroxy-2,3-dihydro-3-hydroxytabersonine, 16-hydroxylochnericine, 16-hydroxyhoerhammericine, quercetin, kaempferol and caffeic acid as substrates

Belongs to the class I-like SAM-binding methyltransferase superfamily, Cation-independent O-methyltransferase family, COMT subfamily


This is Golgin candidate 6 protein, from Mouse-ear cress, contains 914 amino acids, locates in Golgi apparatus.

Golgi matrix protein playing a role in tethering of vesicles to Golgi membranes and in maintaining the overall structure of the Golgi apparatus, Functions in the anterograde transport of storage protein precursors from the endoplasmic reticulum (ER) to the Golgi complex


This is cGMP-specific 3',5'-cGMP phosphodiesterase 3 protein, from Social amoeba, contains 466 amino acids, is soluble, locates in Cytoplasm.

Phosphodiesterase specific for cGMP, which is not activated by cGMP, Involved in the degradation of intracellular cGMP

Belongs to the cyclic nucleotide phosphodiesterase family


This is Metalloprotease TIKI2 protein, from Mouse, contains 517 amino acids, is membrane-bound, locates in Cell membrane.

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins, Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation, Able to cleave WNT3A, WNT5, but not WNT11, Required for head formation (By similarity)


This is Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial protein, from Rat, contains 520 amino acids, is soluble, locates in Mitochondrion.

Key enzyme for ketone body catabolism, Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA, Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity), Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA, Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)

Belongs to the 3-oxoacid CoA-transferase family


This is RNA polymerase I-specific transcription initiation factor RRN3 protein, from Mouse, contains 656 amino acids, locates in Nucleus.

Required for efficient transcription initiation by RNA polymerase I, Required for the formation of the competent preinitiation complex (PIC), Dissociates from pol I as a consequence of transcription, In vitro, cannot activate transcription in a subsequent transcription reaction


This is WD repeat-containing protein 55 protein, from Japanese rice fish, contains 400 amino acids, locates in Nucleus.

Nucleolar protein that acts as a modulator of rRNA synthesis, Plays a central role during organogenesis, including thymus development


This is Phosphatidylcholine:ceramide cholinephosphotransferase 4 protein, from Trypanosoma brucei brucei, contains 365 amino acids, is membrane-bound, locates in Golgi apparatus.

Bifunctional sphingomyelin (SM)/ethanolamine phosphorylceramide (EPC) synthase with minimal inositol phosphorylceramide (IPC) synthase activity (PubMed:18699867, PubMed:20457606, PubMed:19545591, PubMed:21899277), Specificity is likely to be defined by residues in the lumenal catalytic domain that interact with the polar head groups of the phospholipid donors (PubMed:21899277), SM is synthesized by both stages of the parasite life cycle, bloodstream forms (BSF) and procyclic forms (PCF), by transferring the phosphoryl headgroup from a 1,2-diacyl-sn-glycero-3-phosphocholine to an N-acylsphing-4-enine (ceramide) or an N-acylsphinganine (dihydroceramide) with release of 1,2-diacyl-sn-glycerol (PubMed:18699867), Also catalyzes the reverse reaction, production of ceramide from sphingomyelin (PubMed:21899277), EPC is synthesized by transferring phosphoethanolamine from a 1,2-diacyl-sn-glycero-3-phosphoethanolamine to ceramide or dihydroceramide by BSF and PCF, while IPC is confined to PCF (PubMed:18699867), The ceramide/dihydroceramide ratios are skewed towards dihydroceramide in PCF parasites and ceramide in BSF parasites, this is likely due to differential expression and/or regulation of dihydroceramide desaturase, the enzyme responsible for converting dihydroceramide to ceramide (PubMed:18699867)

Belongs to the sphingomyelin synthase family


This is Endo-1,4-beta-xylanase A protein, from Fusarium vascular wilt of tomato, contains 327 amino acids, is soluble, locates in Extracellular.

Catalyzes the hydrolysis of the internal glycosidic bonds in heteroxylans, releasing mainly xylobiose and xylotriose, Most active on oat-spelt xylan

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Mipartoxin-1 protein, from Red-tailed coral snake, contains 81 amino acids, is soluble, locates in Extracellular.

Snake venom neurotoxin that blocks neuromuscular transmission on both avian and mouse nerve-muscle preparations, presenting a postsynaptic action through the nicotinic acetylcholine receptor (nAChR), Reversibly inhibits twitches in mouse phrenic nerve diaphragm and irreversibly in chick biventer cervicis muscle, Has no cytotoxic activity towards C2C12 cells up to 180 ug/ml

Belongs to the snake three-finger toxin family, Short-chain subfamily


This is Purotoxin-2 protein, from Wolf spider, contains 64 amino acids, is soluble, locates in Extracellular.

Enhances the high-affinity desensitization of human P2RX3 purinoceptors (PubMed:22842000), At 50 nM, the toxin decreases the IC(50) for ambient ATP from 2,67 nM to 0,77 nM in human P2RX3 (PubMed:22842000)

Belongs to the neurotoxin 19 (CSTX) family, 05 (U4-Lctx) subfamily


This is Probable peroxygenase 7 protein, from Mouse-ear cress, contains 210 amino acids, is soluble, locates in Extracellular.

Probable calcium-binding peroxygenase, May be involved in pollination


This is Synaptonemal complex central element protein 3 protein, from Mouse, contains 88 amino acids, locates in Nucleus.

Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase, Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes, Chromosome loading appears to require SYCP1, Required for fertility, May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism


This is Preprofallaxidin-6 protein, from Eastern dwarf tree frog, contains 103 amino acids, is soluble, locates in Extracellular.

Fallaxidin-3,1 shows antibacterial activity against the Gram-positive bacteria E,faecalis (MIC=100 uM) and L,lactis (MIC=100 uM), No antibacterial activity against the Gram-positive bacteria B,cereus, L,innocua, M,luteus, S,epidermidis, S,uberis and S,aureus, or the Gram-negative bacteria E,cloacae and E,coli

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is Preprofallaxidin-7 protein, from Eastern dwarf tree frog, contains 132 amino acids, is soluble, locates in Extracellular.

Fallaxidin-1,3 shows no antibacterial activity against Gram-positive or Gram-negative bacteria, Does not inhibit the formation of NO by neuronal nitric oxide synthase, Has no effect on splenocyte proliferation or smooth muscle contraction


This is Immunoglobulin-like domain-containing receptor 2 protein, from Mouse, contains 661 amino acids, has 1 Ig-like V-type Immunoglobulin domain, is membrane-bound, locates in Endoplasmic reticulum.

Ig-like V-type

May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion (PubMed:33863978, PubMed:23826244), With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (PubMed:23239027), Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694), In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060)

Belongs to the immunoglobulin superfamily, LISCH7 family


This is Protein dimmed protein, from Fruit fly, contains 390 amino acids, is soluble, locates in Cytoplasm.

Transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate, Acts as a master regulator of common NS functions such as Phm expression and neuropeptide production, Plays a role as a regulator of peptide-containing large dense-core vesicle (LDCV) production and peptidergic cell differentiation, Controls transcription of FMRFamide in Tv neuronal cells and Fur1 in Ap-let cells (Tvb and dorsal apterous cells), Also required for up-regulation of Phm in Tv and Ap-let cells, and expression of three neuropeptide genes, Ms, FMRFamide and Lk, Influences both regulated and constitutive secretory activity in neuroendocrine cells at embryonic and postembryonic level, Loss of function studies show reduced cellular levels of various neuropeptides and neuropeptide biosynthetic enzymes


This is Toxin Css39.8 protein, from Durango bark scorpion, contains 87 amino acids, is soluble, locates in Extracellular.

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing, This toxin is lethal to crustaceans (freshwater crayfish (Cambarellus montezumae spp,)), it provokes a reversible paralysis to insects (crickets (Achaeta spp,)), but is not toxic to mice, At high concentrations, it does displace the (beta) mammal-specific toxin Cn2 from rat brain synaptosomes

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Kunitz-type serine protease inhibitor taicotoxin protein, from Australian taipan, contains 88 amino acids, is soluble, locates in Extracellular.

Monomer: serine protease inhibitor that inhibits plasma kallikrein (Ki=0,057 nM), tissue kallikrein (Ki=0,23 nM), trypsin (Ki=0,31 nM), plasmin (Ki=6,1 nM), elastase (Ki=201 nM), factor Xa (Ki=871 nM), alpha-factor XIIa (Ki=2380 nM), Does not inhibit APC, urokinase-type plasminogen activator (uPA/PLAU), tissue plasminogen activator (tPA/PLAT), thrombin and factor VIIa, In addition, the monomer inhibits fibrinolysis in whole blood and prolonged the intrinsec clotting time


This is ARMADILLO BTB ARABIDOPSIS PROTEIN 1 protein, from Mouse-ear cress, contains 737 amino acids, locates in Nucleus.

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity), In association with TCP24, exerts a negative role in cell proliferation in leaves, possibly by inhibiting mitotic DNA replication


This is Protein ripply3 protein, from African clawed frog, contains 170 amino acids, locates in Nucleus.

Acts as a transcriptional corepressor, Negative regulator of the transcriptional activity of tbx1 that plays a key role in pharyngeal development, Plays a role in the formation of the anteroposterior (AP) axis during embryonic development; required to establish the posterolateral border of the pre-placodal ectoderm (PPE) acting downstream of the retinoic acid receptor (RAR) signaling


This is Transthyretin protein, from African clawed frog, contains 153 amino acids, is soluble, locates in Extracellular.

Thyroid hormone-binding protein, with a much higher binding affinity for triiodothyronine (T3) than for thyroxine (T4), Probably transports triiodothyronine from the bloodstream to the brain


This is Alkaline/neutral invertase C, mitochondrial protein, from Mouse-ear cress, contains 664 amino acids, locates in Mitochondrion.

Mitochondrial invertase that cleaves sucrose into glucose and fructose and is involved in the regulation of aerial tissue development and floral transition, May be modulating hormone balance in relation to the radicle emergence

Belongs to the glycosyl hydrolase 100 family


This is PTI1-like tyrosine-protein kinase 3 protein, from Mouse-ear cress, contains 408 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Tyr protein kinase family


This is Copper-transporting ATPase PAA2, chloroplastic protein, from Mouse-ear cress, contains 883 amino acids, is membrane-bound, locates in Plastid.

Mediates copper transfer across the chloroplast thylakoid membrane, Required for copper delivery into the thylakoids lumen, which is essential for the function of copper proteins

Belongs to the cation transport ATPase (P-type) (TC 3,A,3) family, Type IB subfamily


This is Basic leucine zipper 63 protein, from Mouse-ear cress, contains 314 amino acids, locates in Nucleus.

Transcription factor involved in controlling responses to starvation (PubMed:26263501), BZIP2-BZIP63-KIN10 complex binds to the ETFQO promoter to up-regulate its transcription (PubMed:29348240)


This is Thiamine pyrophosphokinase 1 protein, from Mouse-ear cress, contains 267 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) (PubMed:17611796), TPP is an active cofactor for enzymes involved in glycolysis and energy production (PubMed:17611796), Plant leaves require high levels of TPP for photosynthesis and carbohydrate metabolism (PubMed:17611796)

Belongs to the thiamine pyrophosphokinase family


This is ARM REPEAT PROTEIN INTERACTING WITH ABF2 protein, from Mouse-ear cress, contains 710 amino acids, locates in Nucleus.

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity), Acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements, Negative regulator of seed germination and young seedling growth


This is NADPH-dependent codeinone reductase 1-5 protein, from Opium poppy, contains 321 amino acids, is soluble, locates in Cytoplasm.

NADPH-dependent codeinone reductase involved in biosynthesis of morphinan-type benzylisoquinoline and opiate alkaloids natural products (PubMed:29779229, PubMed:15543134), Reduces codeinone to codeine in the penultimate step in morphine biosynthesis (PubMed:29779229, PubMed:15543134, PubMed:22098111), Can use morphinone, hydrocodone and hydromorphone as substrate during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrate during oxidative reaction with NADP as cofactor (PubMed:29779229), Converts morphinone to morphine, and neomorphinone to neomorphine (By similarity), Reduces irreversibly neopinone, a spontaneous isomer of codeinone, to neopine; in planta, neopine levels are limited to low levels (PubMed:29779229)

Belongs to the aldo/keto reductase family


This is Nuclear envelope integral membrane protein 1a protein, from African clawed frog, contains 434 amino acids, is membrane-bound, locates in Nucleus.

In concert with ran, required for proper eye development (PubMed:25946333), May be involved in the expression of early eye marker genes (PubMed:19167377), Contributes to nuclear envelope stiffness in germ cells (By similarity), Required for fertility (By similarity)


This is Alpha-mannosidase protein, from Jack bean, contains 981 amino acids, locates in Lysosome/Vacuole.

Liberates mannose from p-nitrophenyl-alpha-D-mannoside (PubMed:12325362, PubMed:4973951, PubMed:1156387), Liberates mannose from further alpha-D-mannosides including methyl-, benzyl-alpha-D-mannoside, 1-6-linked di-, tri- and tetrasaccharides of alpha-D-mannose and mannosyl-rhamnose (PubMed:12325362), Liberates mannose from various glycoproteins like ovalbumin and ovomucoid (PubMed:12325362, PubMed:5145), Does not hydrolyze beta-D-mannosides (PubMed:12325362), Has glycosyltransferase activity, forming disaccharides from mannose and lyxose but not from glucose, galactose, ribose, xylose or arabinose (PubMed:12325362)

Belongs to the glycosyl hydrolase 38 family


This is Fulgimotoxin protein, from Green vine snake, contains 74 amino acids, is soluble, locates in Extracellular.

Reptile-specific three-finger toxin that is lethal at low doses for lizards, but not for mice, Probably acts as a neurotoxin

Belongs to the snake three-finger toxin family, Ancestral subfamily, Boigatoxin sub-subfamily


This is Phospholipase A2 nigroviriditoxin basic subunit B protein, from Black-speckled palm pit viper, contains 122 amino acids, is soluble, locates in Extracellular.

Subunit B: Snake venom phospholipase A2 (PLA2) that induces myonecrosis in mice, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is LRR receptor-like serine/threonine-protein kinase FEI 1 protein, from Mouse-ear cress, contains 591 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the signaling pathway that regulates cell wall function, including cellulose biosynthesis, likely via an 1-aminocyclopropane-1-carboxylic acid (ACC)-mediated signal (a precursor of ethylene)

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is LRR receptor-like serine/threonine-protein kinase FEI 2 protein, from Mouse-ear cress, contains 589 amino acids, is membrane-bound, locates in Cell membrane.


This is Probable leucine-rich repeat receptor-like protein kinase IMK3 protein, from Mouse-ear cress, contains 784 amino acids, is membrane-bound, locates in Cell membrane.


This is Pollen receptor-like kinase 1 protein, from Mouse-ear cress, contains 662 amino acids, is membrane-bound, locates in Cell membrane.

Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth (PubMed:23024212)


This is LRR receptor-like serine/threonine-protein kinase ERL1 protein, from Mouse-ear cress, contains 966 amino acids, is membrane-bound, locates in Cell membrane.

Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ER and ERL2, Redundantly involved with ER in procambial development regulation, Forms a functional ligand-receptor pair with EPF1 (AC Q8S8I4) (PubMed:22241782), Forms a constitutive complex with TMM involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN (PubMed:28536146)


This is Importin subunit alpha-8 protein, from Mouse, contains 499 amino acids, locates in Nucleus.


This is Artemisinic aldehyde Delta(11(13)) reductase protein, from Sweet wormwood, contains 388 amino acids, is soluble, locates in Cytoplasm.

Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:18495659, PubMed:27488942), Catalyzes the double bond reduction of artemisinic aldehyde to produce (11R)-dihydroartemisinic aldehyde (PubMed:18495659), Also able to reduce 2-cyclohexen-1-one into cyclohexanone to a lesser extent (PubMed:18495659)

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family


This is Extra-large guanine nucleotide-binding protein 2 protein, from Mouse-ear cress, contains 861 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (By similarity), Binds GTP with specificity, Plays a role in the root morphogenesis by regulation of the cell proliferation, Acts as a positive regulator in resistance to pathogen that triggers the salicylic acid (SA) pathway, Promotes the DNA binding activity of RTV1 specifically to promoter regions of FT and SOC1 in vivo leading to the activation of floral integrator genes

Belongs to the G-alpha family, XLG subfamily


This is Pyridoxal 5'-phosphate synthase subunit Pdx1 protein, from Plasmodium falciparum (isolate 3D7), contains 301 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia, The ammonia is provided by Pdx2, Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively


This is Flavonoid 3',5'-methyltransferase protein, from Grape, contains 235 amino acids, is soluble, locates in Cytoplasm.

Mediates O-methylation of anthocyanins, Anthocyanins are major pigments in grapes: at ripening initiation in red grapevine berries, the exocarp turns color from green to red and then to purple due to the accumulation and extent of methylation of anthocyanins, Catalyzes both 3' and 5' O-methylation of anthocyanins, with a preference for glycosylated substrates, Active on both anthocyanins and flavonols in vitro, Most active with delphinidin 3-glucoside but also acts on cyanidin 3-glucoside, cyanidin, myricetin, quercetin and quercetin 3-glucoside, Not able to methylate flavan type skeletons with chiral centers, such as catechins or dihydroquercetin

Belongs to the class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family, CCoAMT subfamily


This is Metallophosphoesterase 1 protein, from Chinese hamster, contains 391 amino acids, is membrane-bound, locates in Golgi apparatus.

Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi, Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins

Belongs to the metallophosphoesterase superfamily, MPPE1 family


This is Protein-methionine methyltransferase laeA protein, from Aspergillus nidulans, contains 374 amino acids, locates in Nucleus.

Methyltransferase that performs automethylation at Met-207 (PubMed:23532849), No other methyl-accepting substrate has been identified yet (PubMed:23532849), Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:15075281, PubMed:20132440), Controls the expression of the sterigmatocystin, penicillin, and lovastatin gene clusters (PubMed:15075281, PubMed:16968230), Controls light-dependent formation of the velB-vosA complex, veA protein modification, and is required for light-mediated inhibition of sexual development (PubMed:21152013), Within the velvet complex, controls light-dependent secondary metabolism (PubMed:18556559), Involved in the defense response against Drosophila melanogaster larval grazing (PubMed:24023705)

Belongs to the methyltransferase superfamily, LaeA methyltransferase family


This is Kelch repeat and BTB domain-containing protein 13 protein, from Human, contains 458 amino acids, is soluble, locates in Cytoplasm.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex


This is Gonad-stimulating substance protein, from Starfish, contains 116 amino acids, is soluble, locates in Extracellular.

Induces oocyte maturation and ovulation in vitro in ovarian fragments and induces spawning behavior and gamete release in vivo (PubMed:19470645), Probably mediates its effects by binding to a G-protein coupled receptor located in follicle cell membranes (PubMed:21295575, PubMed:21967225, PubMed:24929230), Following receptor binding, stimulates GTP-dependent adenylyl cyclase activity in follicle cell membranes of fully grown ovaries at stage V but not in young ovaries at stage IV, leading to the production of cAMP (PubMed:21967225, PubMed:22134181), This stimulates the production of the maturation-inducing hormone, 1-methyladenine, in stage V but not stage IV ovaries (PubMed:19470645, PubMed:21295575, PubMed:22134181), The lack of activity in stage IV ovaries may be due to the very low levels of the G-protein alpha s subunit which is not expressed at high levels in follicle cells until stage V (PubMed:24929230)


This is Protein cornichon homolog 3 protein, from Rat, contains 160 amino acids, is membrane-bound, locates in Cell membrane.

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization


This is Myeloid cell nuclear differentiation antigen-like protein protein, from Mouse, contains 538 amino acids, locates in Nucleus.

Suppresses cell growth when expressed ectopically


This is Tar DNA-binding protein homolog 1 protein, from Caenorhabditis elegans, contains 414 amino acids, locates in Cytoplasm.

RNA-binding protein which regulates transcription, splicing and RNA-editing (PubMed:25391662), Limits the accumulation of double-stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs (PubMed:25391662), Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress (PubMed:22232551, PubMed:22792076), Involved in the regulation of physiological processes including aging, fertility, growth and locomotion (PubMed:22232551, PubMed:29760282), Plays a role in maintaining localization of chromobox protein homolog hpl-2 to gene bodies, perhaps acting via binding to nascent RNA transcripts (PubMed:29760282)


This is Zinc finger BED domain-containing protein 6 protein, from Mouse, contains 980 amino acids, has 2 BED-type Zinc finger, locates in Nucleus.

BED-type

BED-type

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799), Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799), Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (PubMed:20016685, PubMed:29440408, PubMed:32557799), Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (PubMed:32557799), Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (PubMed:20016685, PubMed:32557799), Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816), Binds to the CDH2 gene and may directly repress CDH2 transcription (PubMed:26750727), Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (PubMed:26750727), May also play a role in embryonic beta cell differentiation (PubMed:24043816), May play a role in insulin sensitivity and glucose clearance (PubMed:29440408)


This is 1,4-alpha-glucan-branching enzyme 3, chloroplastic/amyloplastic protein, from Mouse-ear cress, contains 899 amino acids, is soluble, locates in Plastid.

Catalyzes the formation of the alpha-1,6-glucosidic linkages in starch by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position, Essential during embryogenesis

Belongs to the glycosyl hydrolase 13 family, GlgB subfamily


This is GTP-binding protein 1 protein, from Rat, contains 669 amino acids, is soluble, locates in Cytoplasm.

Promotes degradation of target mRNA species, Plays a role in the regulation of circadian mRNA stability, Binds GTP and has GTPase activity

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, GTPBP1 subfamily


This is Mu-theraphotoxin-Hhn2b 1 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.

Weakly blocks the rat SCN2A/SCN1B (Nav1,2/beta-1) sodium channel (IC(50)=68 uM) and the insect sodium channel para/tipE (IC(50)=4,3 uM), without altering the activation or inactivation kinetics (depressant toxin)

Belongs to the neurotoxin 10 (Hwtx-1) family, 14 (Hntx-1) subfamily


This is Mu-theraphotoxin-Hhn2b 2 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Mu-theraphotoxin-Hhn2b 3 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 1 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.

Selective antagonist of neuronal tetrodotoxin (TTX)-sensitive voltage-gated sodium channels (IC(50)=1270 nM on Nav1,1/SCN1A, 270 nM on Nav1,2/SCN2A, 491 nM on Nav1,3/SCN3A and 232 nM on Nav1,7/SCN9A), This toxin suppress Nav1,7 current amplitude without significantly altering the activation, inactivation, and repriming kinetics, Short extreme depolarizations partially activate the toxin-bound channel, indicating voltage-dependent inhibition of this toxin, This toxin increases the deactivation of the Nav1,7 current after extreme depolarizations, The toxin-Nav1,7 complex is gradually dissociated upon prolonged strong depolarizations in a voltage-dependent manner, and the unbound toxin rebinds to Nav1,7 after a long repolarization, Moreover, analysis of chimeric channels showed that the DIIS3-S4 linker is critical for toxin binding to Nav1,7, These data are consistent with this toxin interacting with Nav1,7 site 4 and trapping the domain II voltage sensor in the closed state

Belongs to the neurotoxin 10 (Hwtx-1) family, 15 (Hntx-3) subfamily


This is Hainantoxin-III 2 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 4 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 5 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 6 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 7 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 8 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Mu-theraphotoxin-Hhn1b 1 protein, from Chinese bird spider, contains 86 amino acids, is soluble, locates in Extracellular.

Neurotoxin that selectively inhibits neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) (IC(50)=44,6 nM) (PubMed:14512091, PubMed:12518233), It is active on Nav1,2/SCN2A (IC(50)=22,4 nM), Nav1,6/SCN8A (IC(50)=50,1 nM) and Nav1,7/SCN9A (IC(50)=48,9 nM) (PubMed:29703751), It shows low affinity for lipid bilayers (PubMed:29703751)

Belongs to the neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily


This is Mu-theraphotoxin-Hhn1b 2 protein, from Chinese bird spider, contains 86 amino acids, is soluble, locates in Extracellular.

Neurotoxin, Selectively blocks neuronal tetrodotoxin-sensitive voltage-gated sodium channels (Nav) with an IC(50) of 44,6 nM, Does not affect tetrodotoxin-resistant voltage-gated sodium channels or calcium channels


This is Hainantoxin-III 9 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 10 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 11 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Mu-theraphotoxin-Hhn1b 3 protein, from Chinese bird spider, contains 86 amino acids, is soluble, locates in Extracellular.


This is Hainantoxin-III 12 protein, from Chinese bird spider, contains 83 amino acids, is soluble, locates in Extracellular.


This is Killer cell lectin-like receptor subfamily F member 2 protein, from Human, contains 207 amino acids, is membrane-bound, locates in Cell membrane.

C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interaction with CLEC2A


This is Geminin coiled-coil domain-containing protein 1 protein, from African clawed frog, contains 316 amino acids, locates in Nucleus.

Regulator of DNA replication, Promotes initiation of chromosomal DNA replication by mediating topbp1- and cdk2-dependent recruitment of cdc45l onto replication origins


This is Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial protein, from Rat, contains 338 amino acids, is membrane-bound, locates in Mitochondrion.

Has no NAD/NADP-dependent methylenetetrahydrofolate dehydrogenase activity

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family


This is Leucine-rich repeat transmembrane neuronal protein 1 protein, from Rat, contains 523 amino acids, is membrane-bound, locates in Cell membrane.

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level


This is Bromodomain testis-specific protein protein, from Rat, contains 952 amino acids, locates in Nucleus.

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis, Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time, In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA, Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac), Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids, Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin


This is Potassium voltage-gated channel subfamily G member 1 protein, from Rat, contains 514 amino acids, is membrane-bound, locates in Cell membrane.

Potassium channel subunit that does not form functional channels by itself, Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:8980147)

Belongs to the potassium channel family, G (TC 1,A,1,2) subfamily, Kv6,1/KCNG1 sub-subfamily


This is Glutathione hydrolase proenzyme protein, from Trichophyton mentagrophytes, contains 584 amino acids, is soluble, locates in Extracellular.

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds, The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases, In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound, Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level, It is part of the cell antioxidant defense mechanism

Belongs to the gamma-glutamyltransferase family


This is Multicilin protein, from Human, contains 385 amino acids, locates in Nucleus.

Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963), Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis, Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963), Plays a role in mitotic cell cycle progression by promoting cell cycle exit, Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211)


This is Pectinesterase 1 protein, from Common olive, contains 364 amino acids, is soluble, locates in Extracellular.

Catalyzes the demethylesterification of homogalacturonan components of pectin, May be involved in pollen tube development


This is Cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose) protein, from Carnation, contains 502 amino acids, locates in Lysosome/Vacuole.

Beta-glycosidase that catalyzes the transfer of glucose moiety to anthocyanidin 3-glucoside at the 5 position, Anthocyanins are ubiquitous colored pigments that are responsible for variations in petal color, Uses acyl-glucoses, but not UDP-glucose, as the glucose donor

Belongs to the glycosyl hydrolase 1 family


This is Cyanidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose) protein, from Siberian larkspur, contains 505 amino acids, locates in Lysosome/Vacuole.

Beta-glycosidase that catalyzes the transfer of glucose moiety to anthocyanidin 3-glucoside at the 7 position, Anthocyanins are ubiquitous colored pigments that are responsible for variations in petal color


This is Putative beta-neurotoxin RjAa12f protein, from Caribbean blue scorpion, contains 83 amino acids, is soluble, locates in Extracellular.

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing, This toxin is lethal to insects (A,domestica), It is not toxic to mice and does not affect mammal F11 sodium channels

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Myosin light chain kinase 3 protein, from Rat, contains 786 amino acids, is soluble, locates in Cytoplasm.

Calmodulin-dependent kinase that phosphorylates MYL2 in vitro, Promotes sarcomere formation in cardiomyocytes, Increases cardiomyocyte contractility

Belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family


This is Fibrinogen alpha chain protein, from Mouse, contains 789 amino acids, is soluble, locates in Extracellular.

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix, Fibrin has a major function in hemostasis as one of the primary components of blood clots (PubMed:7649481), In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (PubMed:11389004), Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood (PubMed:7649481), However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (PubMed:10930441), Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769), Maternal fibrinogen is essential for successful pregnancy (PubMed:7649481), Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (PubMed:12629066), May also facilitate the immune response via both innate and T-cell mediated pathways (PubMed:23487423)


This is Carcinoembryonic antigen-related cell adhesion molecule 16 protein, from Mouse, contains 426 amino acids, has 2 Ig-like C2-type Immunoglobulin domain, is soluble, locates in Extracellular.

Ig-like C2-type

Ig-like C2-type

Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane

Belongs to the immunoglobulin superfamily, CEA family


This is Zinc finger protein 431 protein, from Mouse, contains 526 amino acids, has 15 C2H2-type Zinc finger, locates in Nucleus.

Sequence-specific DNA binding transcriptional repressor, Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases, Acts as a specific transcriptional repressor for PTCH1 during embryonic development, Required for osteoblast differentiation and sonic hedgehog/SHH signaling response, Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1


This is AP2-associated protein kinase 1 protein, from Bovine, contains 957 amino acids, is membrane-bound, locates in Cell membrane.

Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis, Preferentially, may phosphorylate substrates on threonine residues, Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes, Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes, Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Ovocleidin-116 protein, from Chicken, contains 743 amino acids, is soluble, locates in Extracellular.

Major component of the eggshell matrix, May play an important role in the regulation of calcite growth during eggshell calcification, May also regulate the mineralization process in developing and growing bones


This is Serine protease 56 protein, from Mouse, contains 604 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Serine protease required during eye development


This is Dynamin-related protein 5A protein, from Mouse-ear cress, contains 817 amino acids, is soluble, locates in Cytoplasm.

Probable microtubule-associated force-producing protein that is targeted to the forming cell plate during cytokinesis, May play a role in cell division

Belongs to the TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family


This is E3 ubiquitin-protein ligase CCNB1IP1 homolog protein, from Mouse-ear cress, contains 304 amino acids, has 1 RING-type; degenerate Zinc finger, locates in Nucleus.

RING-type; degenerate

Ubiquitin E3 ligase required for class I crossover (CO) formation during meiosis


This is Mannosyl-oligosaccharide glucosidase GCS1 protein, from Mouse-ear cress, contains 852 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor, Required for the accumulation of seed storage proteins, the formation of protein bodies, cell differentiation, cellulose biosynthesis and organization (in cell walls), cell shape determination and organization (e,g, epidermal cells), and embryo development, Involved in root development

Belongs to the glycosyl hydrolase 63 family


This is Chloroplast sensor kinase, chloroplastic protein, from Mouse-ear cress, contains 611 amino acids, is soluble, locates in Plastid.

Sensor kinase that senses the plastoquinone (PQ) redox state involved in stoichiometry adjustment of both photosystems (e,g, long-term adaptation via transcriptional regulation of reaction center genes of photosystems I and II) and state transitions (e,g, short-term adaptation involving reversible post-translational phosphorylation of light-harvesting complex II, LHC II), thus linking photosynthesis with gene expression in chloroplasts (PubMed:18632566, PubMed:22039472), Autophosphorylates, probably on a tyrosine residue (PubMed:18632566), Probably phosphorylates SIGA/SIG1 in response to plastoquinone redox state modification (PubMed:23754813), Reduced PQ suppresses its autophosphorylation activity, Represses expression of a number of chloroplast-encoded genes (PubMed:31925322)

Belongs to the chloroplast sensor kinase protein family


This is Protein POLLEN DEFECTIVE IN GUIDANCE 1 protein, from Mouse-ear cress, contains 624 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Probable component of the calreticulin 3 (CRT3) complex, acting probably as a co-chaperone involved in protein retention in the endoplasmic reticulum lumen, Required for micropylar pollen tube guidance, Plays an essential role in cell plate orientation or positioning in early embryo patterning


This is Very-long-chain aldehyde decarbonylase CER1 protein, from Mouse-ear cress, contains 625 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Aldehyde decarbonylase involved in the conversion of aldehydes to alkanes, Core component of a very-long-chain alkane synthesis complex, Involved in epicuticular wax biosynthesis and pollen fertility


This is Bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial protein, from Mouse-ear cress, contains 401 amino acids, locates in Mitochondrion.

Possesses 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase activity, Acts as a regulator of ACC levels and causes changes in ethylene levels

Belongs to the ACC deaminase/D-cysteine desulfhydrase family


This is Fructokinase-like 2, chloroplastic protein, from Mouse-ear cress, contains 614 amino acids, locates in Plastid.

Required for proper chloroplast development, most likely through regulating plastid-encoded polymerase (PEP) dependent chloroplast transcription, Acts as a component of the transcriptionally active plastid chromosome that is required for plastid gene expression

Belongs to the carbohydrate kinase PfkB family


This is Lysine-specific demethylase JMJ18 protein, from Mouse-ear cress, contains 819 amino acids, has 1 C5HC2 Zinc finger, locates in Nucleus.

Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a specific activity for H3K4me3 and H3K4me2, No activity on H3K9me3/2, H3K27me3/2 and H3K36me3/2, Involved in the control of flowering time by demethylating H3K4me3 at the FLC locus and repressing its expression, The repression of FLC level and reduction in H3K4me3 at the FLC locus results in induction of the flowering activator FT, which is a downstream target of FLC

Belongs to the JARID1 histone demethylase family


This is Alanine aminotransferase 1, mitochondrial protein, from Mouse-ear cress, contains 543 amino acids, locates in Mitochondrion.

Is the major alanine aminotransferase in roots that catalyzes the conversion of alanine to pyruvate (PubMed:17319845), Involved in the rapid conversion of alanine to pyruvate during recovery from low-oxygen stress (PubMed:17319845)

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily


This is RHOMBOID-like protein 10, chloroplastic protein, from Mouse-ear cress, contains 343 amino acids, is membrane-bound, locates in Plastid.

Rhomboid-type serine protease that catalyzes intramembrane proteolysis (PubMed:22416142, PubMed:22738221), Required for correct root growth, floral development, fertility and photoprotection (PubMed:22416142), May be involved in TIC22 processing during its import and in AOS accumulation in the chloroplast membrane (PubMed:22738221)


This is Pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 protein, from Mouse-ear cress, contains 717 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing, Plays a role during development in processes such as meristem maintenance, leaf morphogenesis and root morphogenesis

Belongs to the DEAD box helicase family, DEAH subfamily, PRP22 sub-subfamily


This is Protein SMAX1-LIKE 8 protein, from Mouse-ear cress, contains 910 amino acids, locates in Nucleus.

Probable component of a transcriptional corepressor complex involved in branching control, Regulates cotyledon expansion and lateral root growth, but not germination or hypocotyl elongation, Promotes auxin transport and PIN1 accumulation in the stem and represses BRC1/TCP18 expression in axillary buds (PubMed:26546447, PubMed:26546446)


This is Basic leucine zipper 34 protein, from Mouse-ear cress, contains 321 amino acids, locates in Nucleus.

Transcriptional activator involved in the sporophytic control of cell wall patterning and gametophytic control of pollen development, May play a role in the control of metabolic pathways regulating cellular transport and lipid metabolism


This is Preprotein translocase subunit SCY2, chloroplastic protein, from Mouse-ear cress, contains 575 amino acids, is membrane-bound, locates in Plastid.

Involved in protein export, Probably interacts with other proteins to allow the postimport or conservative sorting pathway for inner membrane proteins in plastids, Central subunit of the protein translocation channel SecYE, Consists of two halves formed by TMs 1-5 and 6-10, These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back, The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug (By similarity)


This is Thiamine pyrophosphokinase 2 protein, from Mouse-ear cress, contains 267 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) (PubMed:17611796), TPP is an active cofactor for enzymes involved in glycolysis and energy production (PubMed:17611796), Plant leaves require high levels of TPP for photosynthesis and carbohydrate metabolism (PubMed:17611796)

Belongs to the thiamine pyrophosphokinase family


This is UTP--glucose-1-phosphate uridylyltransferase 3, chloroplastic protein, from Mouse-ear cress, contains 883 amino acids, locates in Plastid.

Involved in the biosynthesis of sulfolipids in the chloroplast, Catalyzes the first committed step in sulfolipid biosynthesis, Converts glucose 1-phosphate to UDP-glucose, the precursor of the polar head of sulfolipid, In addition to glucose 1-phosphate, can use galactose 1-phosphate, but with much lower activity, No uridyltransferase activity with other hexose monophosphates, Specific for UTP and cannot use ATP, CTP, and GTP


This is Phosphoglucan phosphatase LSF1, chloroplastic protein, from Mouse-ear cress, contains 591 amino acids, locates in Plastid.

Starch granule-associated phosphoglucan phosphatase involved in the control of starch accumulation, Participates in the regulation of the initial steps of starch degradation at the granule surface, May release a different set of phosphate groups from those removed by DSP4


This is Peptide chain release factor PrfB3, chloroplastic protein, from Mouse-ear cress, contains 406 amino acids, is soluble, locates in Plastid.

Involved in the light- and stress-dependent regulation of stability of 3' processed petB transcripts, thus regulating cytochrome b6 accumulation, a rate-limiting step in photosynthetic electron transport, May be recruited to specifically protect petB transcripts against 3'-5' exonucleolytic attack by masking the 3' ends, Does not function as release factor

Belongs to the prokaryotic/mitochondrial release factor family


This is Folylpolyglutamate synthase protein, from Mouse-ear cress, contains 625 amino acids, is membrane-bound, locates in Mitochondrion.

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis, Essential for organellar and whole-plant folate homeostasis

Belongs to the folylpolyglutamate synthase family


This is Dolichol kinase EVAN protein, from Mouse-ear cress, contains 569 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential for pollen development, Involved in protein N-glycosylation in the endoplasmic reticulum (ER), especially in the female gametophyte, Mediates pollen tube (PT) reception in synergids through protein glycosylation


This is Protein LNK2 protein, from Mouse-ear cress, contains 663 amino acids, locates in Nucleus.

Transcriptional coactivator necessary for expression of the clock genes PRR5 and TOC1 (PubMed:25012192, PubMed:25848708), Antagonizes REV8 function in the regulation of anthocyanin accumulation (PubMed:25848001), Involved in red light input to the clock (PubMed:25012192), Activates clock-controlled genes with afternoon peak (PubMed:23818596), Mediates light inhibition of hypocotyl elongation (PubMed:23818596), Unable to bind to DNA, but recruited to the evening element (EE)-containing region of the PRR5 and TOC1 promoters through its interaction with the DNA binding proteins REV8 and REV4 (PubMed:25012192, PubMed:25848708)


This is Nucleosome assembly protein 1;4 protein, from Mouse-ear cress, contains 317 amino acids, locates in Cytoplasm.

May modulate chromatin structure by regulation of nucleosome assembly/disassembly

Belongs to the nucleosome assembly protein (NAP) family


This is DNA mismatch repair protein MSH5 protein, from Mouse-ear cress, contains 807 amino acids, locates in Nucleus.

Involved in meiotic recombination in association with MSH4, Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis, Promotes homologous recombination through facilitating chiasma formation during prophase I, Involved in the control of class I crossovers formation

Belongs to the DNA mismatch repair MutS family


This is Putative GTP diphosphokinase RSH1, chloroplastic protein, from Mouse-ear cress, contains 884 amino acids, locates in Plastid.

May be involved in a rapid plant ppGpp (guanosine 3'-diphosphate 5'-diphosphate)-mediated response to pathogens and other stresses (By similarity), Unable to functionally complement E,coli relA mutants


This is Proteinaceous RNase P 3 protein, from Mouse-ear cress, contains 576 amino acids, locates in Nucleus.

Endonuclease RNase P responsible for the 5' maturation of tRNA precursors, Also involved in the maturation of mRNA and small nucleolar RNA (snoRNA)


This is DNA mismatch repair protein MSH4 protein, from Mouse-ear cress, contains 792 amino acids, locates in Nucleus.

Involved in meiotic recombination in association with MSH5, Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis, Promotes homologous recombination through facilitating chiasma formation during prophase I, Involved in the control of class I crossovers formation


This is Serine/threonine-protein kinase STY46 protein, from Mouse-ear cress, contains 575 amino acids, is soluble, locates in Cytoplasm.

Serine/threonine protein kinase that specifically phosphorylates chloroplast precursor proteins in the cytosol within the cleavable presequences (transit peptides), May be part of a cytosolic regulatory network involved in chloroplast protein import, Does not phosphorylate mitochondrion precursor proteins, Specific for ATP and does not utilize other NTPs (PubMed:17090544, PubMed:16429265), Plays a role in chloroplast biogenesis and differentiation in cotyledons, possibly through phosphorylation of chloroplast preproteins (PubMed:21799034)


This is CRM-domain containing factor CFM3B, chloroplastic protein, from Mouse-ear cress, contains 907 amino acids, locates in Plastid.

Binds specific group II introns in chloroplasts and facilitates their splicing (PubMed:18799595, PubMed:32143506), Exhibits non-specific action during plastid rRNA biogenesis; RFC3 prevents unaccurate splicing to improve the accuracy of plastid rRNA processing (PubMed:32143506), Acts on subgroup IIB introns (PubMed:18799595), The substrates of the subgroup IIB also require the CRM domain proteins CAF1 or CAF2, with a simultaneous binding of CFM3B and CAF1 or CAF2 (PubMed:18799595), Required for seed development (PubMed:18799595)


This is Transcription termination factor MTERF5, chloroplastic protein, from Mouse-ear cress, contains 493 amino acids, locates in Plastid.

Transcription termination factor required for processing and steady-state levels of plastid transcripts (PubMed:22905186), Involved also in chloroplast transcriptional pausing, a general feature of chloroplast genes (PubMed:31128276), Specifically and positively regulates the transcription of chloroplast psbEFLJ encoding for photosystem II (PSII) core subunits psbE, psbF, psbL and psbJ; causes the plastid-encoded RNA polymerase (PEP) complex to pause at psbEFLJ by binding to the +30 to +51 region of double-stranded DNA, and recruits additional pTAC6 to the transcriptionally paused region of psbEFLJ (PubMed:31128276), May play a role in response to abiotic stresses (PubMed:22905186)


This is Phosphatidylinositol-3-phosphatase myotubularin-2 protein, from Mouse-ear cress, contains 833 amino acids, is soluble, locates in Cytoplasm.

Phosphatase with phosphoinositide 3'-phosphatase activity that can use phosphatidylinositol-3-phosphate (PtdIns3P) and phosphatidylinositol-3,5-diphosphate (PtdIns3,5P(2)) as substrates and produces phosphatidylinositol-5-phosphate (PtdIns5P); participates in pathway(s) that transfer gene regulatory signals to the nucleus

Belongs to the protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily


This is Cytosolic endo-beta-N-acetylglucosaminidase 1 protein, from Mouse-ear cress, contains 680 amino acids, is soluble, locates in Cytoplasm.

Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core, Involved in the production of high-mannose type N-glycans during plant development and fruit maturation

Belongs to the glycosyl hydrolase 85 family


This is Thylakoid membrane protein TERC, chloroplastic protein, from Mouse-ear cress, contains 384 amino acids, is membrane-bound, locates in Plastid.

Integral thylakoid membrane protein that plays a crucial role in thylakoid membrane biogenesis and thylakoid formation in early chloroplast development (PubMed:18429937), Is essential for de novo synthesis of photosystem II (PSII) core proteins and required for efficient insertion of thylakoid membrane proteins, presumably via interaction with ALB3, May assist synthesis of thylakoid membrane proteins at the membrane insertion step (PubMed:24612058)


This is Folylpolyglutamate synthase protein, from Mouse-ear cress, contains 571 amino acids, locates in Plastid.

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis, Essential for organellar and whole-plant folate homeostasis, Required for postembryonic root development, Generates polyglutamylated folate cofactors to support C1 metabolism required for meristem maintenance and cell expansion during postembryonic root development


This is Probable inactive ATP-dependent zinc metalloprotease FTSHI 4, chloroplastic protein, from Mouse-ear cress, contains 855 amino acids, is membrane-bound, locates in Plastid.

Functions in chloroplast biogenesis and chloroplast division, Required for plastid development during embryogenesis (PubMed:24964212), Might be involved in chaperone functions or play a structural role in the thylakoid FtsH complex (PubMed:12185496)


This is Serine/arginine-rich splicing factor 6 protein, from Rat, contains 339 amino acids, locates in Nucleus.

Plays a role in constitutive splicing and modulates the selection of alternative splice sites, Plays a role in the alternative splicing of MAPT/Tau exon 10, Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC, Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity)

Belongs to the splicing factor SR family


This is Potassium channel subfamily K member 4 protein, from Rat, contains 397 amino acids, is membrane-bound, locates in Cell membrane.

Voltage-insensitive potassium channel (PubMed:11374070, PubMed:15677687), Channel opening is triggered by mechanical forces that deform the membrane, and by raising the intracellular pH to basic levels (PubMed:11374070, PubMed:15677687), The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (PubMed:15677687), Plays a role in the perception of pain caused by heat (By similarity), Plays a role in the sensory perception of pain caused by pressure (By similarity)

Belongs to the two pore domain potassium channel (TC 1,A,1,8) family


This is Protein O-glucosyltransferase 1 protein, from Rat, contains 392 amino acids, is soluble, locates in Endoplasmic reticulum.

Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C, Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (By similarity), Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity), Notch glucosylation does not affect Notch ligand binding (By similarity), Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity)

Belongs to the glycosyltransferase 90 family


This is Protein CHAPERONE-LIKE PROTEIN OF POR1, chloroplastic protein, from Nicotiana benthamiana, contains 252 amino acids, is membrane-bound, locates in Plastid.

Exhibits holdase chaperone activity involved in the stabilization of POR proteins against photooxidative stress in chloroplasts, Required for chloroplast development

Belongs to the chaperone-like protein of POR1 protein family


This is Na(+)/H(+) exchanger protein 7 protein, from Caenorhabditis elegans, contains 783 amino acids, is membrane-bound, locates in Cell membrane.

Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation (PubMed:18191228, PubMed:18291648, PubMed:23319594), Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells (PubMed:25849533)

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2,A,36) family


This is Protein mes-1 protein, from Caenorhabditis elegans, contains 966 amino acids, is membrane-bound, locates in Cell membrane.

During early embryogenesis, controls asymmetric cell division and the asymmetric localization of P granules of germline precursor P2 and its descendant P3 (PubMed:7555722), Probably upstream of tyrosine kinase src-1, plays a role in endoderm development by controlling spindle orientation during EMS blastomere cell division (PubMed:12110172), Controls EMS spindle orientation probably by promoting lin-5 and gpr-1/2 enrichment at, and let-99 exclusion from the junction between P2 and EMS cells (PubMed:14534135, PubMed:12730122)

Belongs to the protein kinase superfamily


This is Sodium- and chloride-dependent betaine transporter protein, from Caenorhabditis elegans, contains 600 amino acids, is membrane-bound, locates in Cell membrane.

Betaine transporter dependent on Na(+) and Cl(-) ions that functions primarily in the epidermis to clear betaine from the extracellular space, Elicits current in response to betaine but not in response to GABA, L-carnitine, sarcosine, glycine or dimethylglycine

Belongs to the sodium:neurotransmitter symporter (SNF) family


This is Glutamate-gated chloride channel alpha protein, from Caenorhabditis elegans, contains 461 amino acids, is membrane-bound, locates in Cell membrane.

Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition, Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration, Channels containing only glc-1 are activated by ivermectin, but not by glutamate alone (in vitro), The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid (PubMed:7935817), Plays a role in the regulation of locomotor behavior (PubMed:16527366)

Belongs to the ligand-gated ion channel (TC 1,A,9) family, Glutamate-gated chloride channel (TC 1,A,9,4) subfamily


This is Zinc finger E-box-binding homeobox protein zag-1 protein, from Caenorhabditis elegans, contains 596 amino acids, has 3 C2H2-type Zinc finger, has 1 C2H2-type 2; degenerate Zinc finger, has 1 C2H2-type 5; degenerate Zinc finger, locates in Nucleus.

C2H2-type 2; degenerate

C2H2-type 5; degenerate

Transcription factor (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162), Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA (PubMed:12835394), Acts as a transcriptional repressor to regulate multiple, discrete, neuron-specific aspects of terminal differentiation, including cell migration, axonal development and gene expression (PubMed:12835394, PubMed:12835395, PubMed:25474681, PubMed:30291162), Promotes touch receptor neuron differentiation by repressing the expression of egl-44 and egl-46 (PubMed:30291162), As egl-44 and egl-46, probably acting as a heterodimer, repress expression of zag-1 in FLP neurons, together these proteins form a bistable, negative-feedback loop that regulates the choice between neuronal fates (PubMed:30291162), Required for axon guidance (PubMed:12835395), Involved in the proper development of the pharynx (PubMed:12835395), Required for pharynx isthmus peristalsis, probably via a role in the differentiation of the M4 cholinergic motor neuron (PubMed:25474681), Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter (PubMed:12835394, PubMed:12835395), May also act as a transcriptional activator of the homeodomain ceh-28 (PubMed:25474681)


This is Tyrosine-protein phosphatase non-receptor type ptp-2 protein, from Caenorhabditis elegans, contains 668 amino acids, is soluble, locates in Cytoplasm.

Involved in embryonic and larval development (PubMed:9472025, PubMed:20380830), Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP) (PubMed:9472025, PubMed:20380830), During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15 (PubMed:16495308), Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1 (PubMed:11689700), Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23 (PubMed:9472025, PubMed:16547100), Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100)

Belongs to the protein-tyrosine phosphatase family, Non-receptor class 2 subfamily