This is Delta-ctenitoxin-Pn1b protein, from Brazilian armed spider, contains 48 amino acids, is soluble, locates in Extracellular.

Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav) (By similarity), Inhibits glutamate uptake in rat brain synaptosomes (PubMed:14757211), In vivo, induces immediate excitatory effects when injected intrathoracically in houseflies and cockroaches (PubMed:14757211)

Belongs to the neurotoxin 03 (Tx2) family, 05 subfamily


This is Defensin ARD1 protein, from One-spotted leafwing butterfly, contains 44 amino acids, is soluble, locates in Extracellular.

Belongs to the invertebrate defensin family, Type 2 subfamily


This is Bombesin protein, from Yellow-bellied toad, contains 107 amino acids, is soluble, locates in Extracellular.

Stimulates smooth muscle contraction, Role in induction of hypothermia, stimulation of DNA replication and release of many gastrointestinal hormones, Possesses insulin-releasing activity

Belongs to the bombesin/neuromedin-B/ranatensin family


This is Palustrin-1c protein, from Pickerel frog, contains 68 amino acids, is soluble, locates in Extracellular.

Antimicrobial activity against Gram-negative bacterium E,coli, Stimulates insulin release

Belongs to the frog skin active peptide (FSAP) family, Brevinin subfamily


This is Hemocyanin subunit 2 protein, from Green crab, contains 650 amino acids, is soluble, locates in Extracellular.

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods

Belongs to the tyrosinase family, Hemocyanin subfamily


This is Phylloseptin-H2 protein, from Orange-legged leaf frog, contains 66 amino acids, is soluble, locates in Extracellular.

Has antimicrobial activity, No hemolytic activity

Belongs to the frog skin active peptide (FSAP) family, Phylloseptin subfamily


This is Phylloseptin-H5 protein, from Orange-legged leaf frog, contains 66 amino acids, is soluble, locates in Extracellular.

Has antibacterial activity against the Gram-negative bacteria E,coli and P,aeruginosa, and the Gram-positive bacterium S,aureus, No hemolytic activity


This is Alpha-toxin Bs-Tx28 protein, from Scorpion, contains 65 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission, This toxin inhibits the inactivation of activated TTX-sensitive sodium channels (Nav)

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily


This is Acidic phospholipase A2 protein, from Central American bushmaster, contains 122 amino acids, is soluble, locates in Extracellular.

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides

Belongs to the phospholipase A2 family, Group II subfamily, D49 sub-subfamily


This is Toxin To5 protein, from Amazonian scorpion, contains 84 amino acids, is soluble, locates in Extracellular.

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily


This is Basic phospholipase A2 homolog zhaoermiatoxin protein, from Mangshan pitviper, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 homolog that induces myonecrosis, and edema, Has low myotoxic activity

Belongs to the phospholipase A2 family, Group II subfamily, R49 sub-subfamily


This is Thrombin-like enzyme elegaxobin-1 protein, from Elegant pitviper, contains 233 amino acids, is soluble, locates in Extracellular.

Thrombin-like snake venom serine protease that clots rabbit fibrinogen, Only the beta chain of fibrinogen (FGB) is cleaved, releasing fibrinopeptide B, Incubation with human fibrinogen alpha and beta resulted in cleavage of both fibrinogen chains but generated neither fibrinopeptide A nor fibrinopeptide B, Promotes clotting of rabbit fibrinogen, but not bovine or human fibrinogen

Belongs to the peptidase S1 family, Snake venom subfamily


This is Vasotab protein, from Horse fly, contains 76 amino acids, is soluble, locates in Extracellular.

Vasodilator protein that inhibits vasoconstriction of isolated rat femoral artery induced by phenylephrine, Since platelet aggregation and vasoconstriction are key hemostatic responses, particularly in small wounds, this protein likely participates in the antihemostatic responses during blood feeding, Blocks L-type calcium channels (Cav1/CACNA1) in left ventricular myocytes isolated from rat hearts


This is Ribonuclease protein, from Green sea-turtle, contains 119 amino acids, is soluble, locates in Extracellular.

Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides, Acts on single-stranded and double-stranded RNA (By similarity)

Belongs to the pancreatic ribonuclease family


This is Esculentin-1SEb protein, from Dusky gopher frog, contains 46 amino acids, is soluble, locates in Extracellular.

Mast cell degranulating peptide, Causes histamine release from rat peritoneal mast cells in vitro, Has antibacterial activity against the Gram-negative bacterium E,coli K12 and Gram-positive bacterium M,luteus NCT C2665

Belongs to the frog skin active peptide (FSAP) family, Esculentin subfamily


This is Esculentin-1SEa protein, from Dusky gopher frog, contains 46 amino acids, is soluble, locates in Extracellular.


This is Omega-lycotoxin-Gsp2671a protein, from Wolf spider, contains 87 amino acids, is soluble, locates in Extracellular.

Modulates P-type voltage-gated calcium channels (Cav2,1/CACNA1A) in rat cerebellar Purkinje cells and hippocampal CA1-CA3 neurons, At saturating concentrations (>10 nM) the toxin decelerates activation kinetics and slightly increases peak amplitude without affecting deactivation kinetics

Belongs to the neurotoxin (omega-lctx) family


This is Lebocin-like anionic peptide 1 protein, from Greater wax moth, contains 42 amino acids, is soluble, locates in Extracellular.

Antimicrobial protein, Has antibacterial activity against the Gram-positive bacteria M,luteus (MIC=22,7 uM) and L,monocytogenes (MIC=90,9 uM), Lacks antibacterial activity against the Gram-positive bacteria B,circulans, S,aureus, and S,lutea, and the Gram-negative bacteria E,coli D31, E,coli ATCC 25922, and S,typhimurium, Has antifungal activity against A,niger (MIC=90,9 uM) and T,harzianum (MIC=90,9 uM), but lacks antifungal activity against S,cerevisiae, P,pastoris, Z,marxianus, C,albicans, C,fructus, and F,oxysporum


This is Defensin protein, from Greater wax moth, contains 72 amino acids, is soluble, locates in Extracellular.

Has antifungal activity against A,niger (MIC=2,1 uM), C,albicans (MIC=8,5 uM), C,fructus (MIC=8,5 uM), F,oxysporum (MIC=16,9 uM), P,pastoris (MIC=16,9 uM), P,tannophilus (MIC=8,5 uM), T,harzianum (MIC=4,2 uM), and Z,marxianus (MIC=8,5 uM), Lacks antibacterial activity against the Gram-positive bacteria L,monocytogenes, M,luteus, S,aureus, and S,lutea, and the Gram-negative bacteria E,coli D31, E,coli ATCC 25922, and S,typhimurium


This is Defensin-like peptide protein, from Greater wax moth, contains 44 amino acids, is soluble, locates in Extracellular.

Has antibacterial activity against the Gram-positive bacterium S,lutea (MIC=1,9 uM), Lacks antibacterial activity against the Gram-positive bacteria L,monocytogenes and M,luteus, and the Gram-negative bacteria E,coli D31, E,coli ATCC 25922, and S,typhimurium, Has antifungal activity against A,niger (MIC=2,9 uM), C,albicans (MIC=2,9 uM), C,fructus (MIC=2,9 uM), C,wickerhamii (MIC=2,9 uM), P,pastoris (MIC=2,9 uM), P,stiptis (MIC=2,9 uM), P,tannophilus (MIC=2,9 uM), T,harzianum (MIC=2,9 uM), and Z,marxianus (MIC=2,9 uM), but lacks antifungal activity against C,albidus, F,oxysporum, and S,cerevisiae


This is M-zodatoxin-Lt8h protein, from Spider, contains 129 amino acids, is soluble, locates in Extracellular.

Insecticidal, cytolytic and antimicrobial peptide, Has insecticidal activity against the flesh fly S,carnaria, Has antibacterial activity against the Gram-negative bacteria E,coli, Forms voltage-dependent, ion-permeable channels in membranes, At high concentration causes cell membrane lysis

Belongs to the cationic peptide 06 (cytoinsectotoxin) family


This is M-zodatoxin-Lt8f protein, from Spider, contains 129 amino acids, is soluble, locates in Extracellular.


This is M-zodatoxin-Lt8g protein, from Spider, contains 129 amino acids, is soluble, locates in Extracellular.


This is Elongation factor Tu, mitochondrial protein, from Rat, contains 452 amino acids, locates in Mitochondrion.

Plays a role in the regulation of autophagy and innate immunity, Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway, In turn, inhibits RLR-mediated type I interferon while promoting autophagy, Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Belongs to the TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-Tu/EF-1A subfamily


This is Phylloseptin-Az2 protein, from Orange-legged monkey tree frog, contains 66 amino acids, is soluble, locates in Extracellular.

Has antibacterial activity against the Gram-negative bacteria E,coli ATCC 11775 (MIC=7,2 uM), and the Gram-positive bacteria S,aureus ATCC 12600 (MIC=3,6 uM) and M,luteus ATCC 49732 (MIC=1,8 uM), Does not inhibit the growth of the fungus C,albicans


This is Ranakinin-N protein, from Black-striped frog, contains 58 amino acids, is soluble, locates in Extracellular.

Induces contraction of intestinal smooth muscle in isolated guinea pig ileum, May induce relaxation of arterial smooth muscle, May target bradykinin receptors (BDKRB), Lacks antibacterial activity against the Gram-positive bacterium S,aureus and the Gram-negative bacteria E,coli and B,dysenteria, and antifungal activity against C,albicans


This is Potassium channel toxin kappa-KTx 2.5 protein, from South American scorpion, contains 70 amino acids, is soluble, locates in Extracellular.

Voltage-independently blocks potassium currents on hKv1,1/KCNA1 (IC(50)=217 uM), and hKv1,4/KCNA4 (IC(50)=71 uM) (expressed in CHO cells)

Belongs to the short scorpion toxin superfamily, Potassium channel inhibitor kappa-KTx family, Kappa-KTx 2 subfamily


This is Crotamine-IV-2 protein, from South American rattlesnake, contains 42 amino acids, is soluble, locates in Extracellular.

Cationic peptide that possesses multiple functions, It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor, It exhibits antimicrobial activities, and hind limb paralysis (By similarity), It also induces potent blockade of neuromuscular transmission in young chicken biventer cervicis preparation and potent myotoxic effect, In mice, it induces myonecrosis, upon intramuscular or subcutaneous injections (PubMed:17828447)

Belongs to the crotamine-myotoxin family


This is Crotamine-IV-3 protein, from South American rattlesnake, contains 42 amino acids, is soluble, locates in Extracellular.


This is Acidic phospholipase A2 2 protein, from Terciopelo, contains 124 amino acids, is soluble, locates in Extracellular.

PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is Sodium channel neurotoxin MeuNaTxalpha-2 protein, from Lesser Asian scorpion, contains 85 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission, This toxin inhibits inactivation of Nav1,4/SCN4A (EC(50)=2,23 uM) and drosophila DmNav1 (EC(50)=220 nM) (PubMed:21969612, Ref,2), The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612), In addition, the toxin accelerates the recovery from fast inactivation in Nav1,4/SCN4A and DmNav1 (PubMed:21969612), It also shows antimicrobial activity (Ref,2)


This is Sodium channel neurotoxin MeuNaTxalpha-4 protein, from Lesser Asian scorpion, contains 86 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission, This toxin inhibits inactivation of drosophila DmNav1 (EC(50)=130 nM) (PubMed:21969612, Ref,2)


This is Sodium channel neurotoxin MeuNaTxalpha-5 protein, from Lesser Asian scorpion, contains 86 amino acids, is soluble, locates in Extracellular.

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission, This toxin inhibits inactivation of Nav1,6/SCN8A (EC(50)=790 nM) and drosophila DmNav1 (EC(50)=280 nM) (PubMed:21969612, Ref,2), The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612), Has antimicrobial activity (Ref,2)


This is Sodium channel neurotoxin MeuNaTxalpha-15 protein, from Lesser Asian scorpion, contains 86 amino acids, is soluble, locates in Extracellular.

Inhibits sodium channels (Nav), Has antimicrobial activity

Belongs to the long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family


This is Rho-elapitoxin-Da1b protein, from Eastern green mamba, contains 66 amino acids, is soluble, locates in Extracellular.

Non-competitive antagonist of alpha-2 adrenergic receptors (ADRA2) in smooth muscles, and partial antagonist of D3 dopamine receptors (DRD3) (inhibits 25% of methylspiperone binding to this receptor) (PubMed:20659106), Also shows a low antagonism on D2 dopamine receptors (DRD2) (short isoform) (PubMed:24793485), Shows high affinity to adrenergic receptors (Ki=14 nM (ADRA2A), Ki=73 nM (ADRA2B), and Ki=38 nM (ADRA2C)) (PubMed:20659106), Increases heart rate and blood catecholamine concentrations (PubMed:21419153)

Belongs to the snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily


This is Acidic phospholipase A2 SpII RP4 protein, from Urutu, contains 121 amino acids, is soluble, locates in Extracellular.

Snake venom phospholipase A2 (PLA2) which exhibits indirect hemolysis, induces mild edema inflammation in the foot pads of mice and slightly delays anticoagulant activities, In mice, not lethal, even at the highest dose, and exhibits low to moderate myotoxicity on muscular fibers, PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides


This is Venom allergen 5 protein, from Neotropical social wasp, contains 207 amino acids, is soluble, locates in Extracellular.

Belongs to the CRISP family, Venom allergen 5-like subfamily


This is Vacuolar fusion protein CCZ1 homolog protein, from Human, contains 482 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991)


This is L-amino-acid oxidase protein, from White-spotted spinefoot, contains 527 amino acids, is soluble, locates in Extracellular.

Inhibits the growth of both Gram-negative and Gram-positive bacteria, Displays strong antibacterial activity towards V,cholerae and E,tarda, Causes deformation of the surface of S,aureus and the formation of pores on the surface of E,coli, Strong antiparasitic activity is seen towards C,irritans, T,brucei and I,multifiliis, Cilia of treated theronts are lost and the macronucleus swells, inducing cell membrane rupture and efflux of the cytoplasm

Belongs to the flavin monoamine oxidase family, FIG1 subfamily


This is Intelectin-like protein protein, from American alligator, contains 313 amino acids, is soluble, locates in Extracellular.

Binds mannan, mannose and, to a lesser degree, D-lactose, N-acetylgalactosamine, N-acetylglucosamine and beta-D-glucose


This is ATP-dependent helicase fft1 protein, from Fission yeast, contains 944 amino acids, locates in Nucleus.

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization

Belongs to the SNF2/RAD54 helicase family


This is Transcriptional activator spt7 protein, from Fission yeast, contains 992 amino acids, locates in Nucleus.

Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK, SAGA is involved in RNA polymerase II-dependent transcriptional regulation, At the promoters, SAGA is required for recruitment of the basal transcription machinery, It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination, SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac), SAGA interacts with DNA via upstream activating sequences (UASs), SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation, SLIK is proposed to have partly overlapping functions with SAGA, It preferentially acetylates methylated histone H3 (By similarity)


This is Probable ADP-ribosylation factor-binding protein C25H2.16c protein, from Fission yeast, contains 533 amino acids, locates in Golgi apparatus.

May play a role in the regulation of membrane traffic through the trans-Golgi network


This is SWM histone demethylase complex subunit phf1 protein, from Fission yeast, contains 461 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor, Has a role in regulating heterochromatin propagation and euchromatic transcription


This is Spindle pole body component alp16 protein, from Fission yeast, contains 759 amino acids, is soluble, locates in Cytoplasm.

Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles


This is Pachytene arrest protein SAE3 protein, from Baker's yeast, contains 91 amino acids, locates in Nucleus.

Involved in meiotic DNA-break repair, Required for the recruitment of DCM1 to meiosis recombination hot spots


This is Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal protein, from Leishmania mexicana, contains 366 amino acids, locates in Peroxisome.

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family


This is GATA-binding factor C protein, from Fruit fly, contains 486 amino acids, has 2 GATA-type Zinc finger, locates in Nucleus.

GATA-type

GATA-type

Transcription factor that is vital to the development of multiple organ systems, Binds to the core consensus sequence 5'-WGATAR-3'


This is Macrophage migration inhibitory factor homolog protein, from Filarial nematode worm, contains 115 amino acids, is soluble, locates in Extracellular.

Tautomerization of the methyl ester of L-dopachrome (By similarity), Inhibits migration of human peripheral blood mononuclear cells


This is snRNA-activating protein complex subunit 4 homolog protein, from Caenorhabditis elegans, contains 944 amino acids, locates in Nucleus.

Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes, Required for expression of mature 21U-RNAs


This is Mitochondrial import receptor subunit TOM20 protein, from Potato, contains 204 amino acids, is membrane-bound, locates in Mitochondrion.

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins, Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore


This is Probable xyloglucan endotransglucosylase/hydrolase protein protein, from Common tobacco, contains 295 amino acids, is soluble, locates in Extracellular.

Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET), Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues

Belongs to the glycosyl hydrolase 16 family, XTH group 1 subfamily


This is Rust resistance kinase Lr10 protein, from Wheat, contains 636 amino acids, is membrane-bound, locates in Cell membrane.

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Lon protease homolog, mitochondrial protein, from Maize, contains 964 amino acids, is soluble, locates in Mitochondrion.

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix, May also have a chaperone function in the assembly of inner membrane protein complexes, Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome, Binds to mitochondrial DNA in a site-specific manner


This is Lon protease homolog 1, mitochondrial protein, from Mouse-ear cress, contains 940 amino acids, is soluble, locates in Mitochondrion.


This is Pre-mRNA-splicing factor 38 protein, from Baker's yeast, contains 242 amino acids, locates in Nucleus.

Required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels, Implicated in the formation of stable and biologically active snRNP structures, As part of the U4/U6,U5 tri-snRNP particle, dispensible for spliceosome assembly, but required for conformational changes, which result in U4 snRNA release and the subsequent catalytic activation of the spliceosome


This is Alcohol oxidase protein, from Yeast, contains 663 amino acids, is soluble, locates in Peroxisome.

Catalyzes the oxidation of methanol to formaldehyde and hydrogen peroxide, the first step in the methanol utilization pathway of methylotrophic yeasts

Belongs to the GMC oxidoreductase family


This is Endo-1,4-beta-xylanase 2 protein, from Crabgrass-specific blast fungus, contains 331 amino acids, is soluble, locates in Extracellular.

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose, Accounts for approximately 70 percent of the endoxylanase activity in the culture filtrate

Belongs to the glycosyl hydrolase 10 (cellulase F) family


This is Flagellar radial spoke protein 6 protein, from Chlamydomonas smithii, contains 459 amino acids, is soluble, locates in Cytoplasm.

Flagellar radial spokes contribute to the regulation of dynein arm activity and thus the pattern of flagellar bending, They consist of a thin stalk, which is attached to the a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules

Belongs to the flagellar radial spoke RSP4/6 family


This is Aspartate aminotransferase, mitochondrial protein, from Baker's yeast, contains 451 amino acids, is soluble, locates in Mitochondrion.

Plays a key role in amino acid metabolism, Important for metabolite exchange between mitochondria and cytosol (By similarity)

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family


This is N-alpha-acetyltransferase 35, NatC auxiliary subunit protein, from Baker's yeast, contains 733 amino acids, is soluble, locates in Cytoplasm.

Component of the NatC N-terminal acetyltransferase, which catalyzes acetylation of the N-terminus Met of L-A virus Gag protein, MAK10 has a role in the propagation of L-A and M viruses, perhaps in the viral assembly, It is apparently directly needed for optimum respiration


This is 5-hydroxytryptamine receptor 1F protein, from Mouse, contains 366 amino acids, is membrane-bound, locates in Cell membrane.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin), Also functions as a receptor for various alkaloids and psychoactive substances, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase, Signaling inhibits adenylate cyclase activity

Belongs to the G-protein coupled receptor 1 family


This is Meiotic recombination protein REC102 protein, from Baker's yeast, contains 264 amino acids, locates in Nucleus.

Required for formation of the SPO11-mediated double-strand breaks (DSBs) that initiate meiotic recombination, May mediate the interaction between SPO11 subunits during meiosis, Also needed for homolog chromosome pairing, synaptonemal complex formation, and for the proper timing of the first meiotic division, Not required for mitosis and mitotic DNA repair mechanisms


This is Large ribosomal subunit protein eL21A protein, from Baker's yeast, contains 160 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel

Belongs to the eukaryotic ribosomal protein eL21 family


This is Mitochondrial inner membrane magnesium transporter MFM1 protein, from Baker's yeast, contains 413 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis, Modulates the conductance of the MRS2 channel, Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing

Belongs to the CorA metal ion transporter (MIT) (TC 1,A,35) family


This is Transcriptional regulatory protein LGE1 protein, from Baker's yeast, contains 332 amino acids, locates in Nucleus.

Required to activate transcription of PDR3, a gene involved in retrograde regulation of multidrug resistance, a phenomenon that takes place in cells that have lost their mitochondrial genome, Also required for ubiquitination of histone H2B to form H2BK123ub1, H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation, Its precise role in H2BK123ub1 formation however is unclear and is independent of retrograde regulation of multidrug resistance function


This is Peroxisomal membrane protein PEX25 protein, from Baker's yeast, contains 394 amino acids, is membrane-bound, locates in Peroxisome.

Required for regulation of peroxisome size and maintenance, Has a role in the import of peroxisomal matrix proteins, Imports RHO1 into the peroxisome, Also promotes peroxisome division and biogenesis


This is RNA polymerase I-specific transcription initiation factor RRN5 protein, from Baker's yeast, contains 363 amino acids, locates in Nucleus.

Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex, Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level


This is Fatty acyl-CoA synthetase and RNA processing-associated kinase 1 protein, from Baker's yeast, contains 865 amino acids, is soluble, locates in Cytoplasm.

Putative serine/threonine-protein kinase that may be involved in rRNA transcription and ribosome biogenesis


This is Lysosomal aspartic protease protein, from Yellowfever mosquito, contains 387 amino acids, locates in Lysosome/Vacuole.

May degrade organelles involved in the biosynthesis and secretion of vitellogenin


This is Small ribosomal subunit protein uS17m protein, from Baker's yeast, contains 237 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (PubMed:25609543, PubMed:28154081), uS17m may have a meiosis-specific role as it accumulates during the middle stage of sporulation (PubMed:15543521)

Belongs to the universal ribosomal protein uS17 family


This is Inner nuclear membrane protein HEH2 protein, from Baker's yeast, contains 663 amino acids, is membrane-bound, locates in Nucleus.


This is Mitochondrial fusion and transport protein UGO1 protein, from Baker's yeast, contains 502 amino acids, is membrane-bound, locates in Mitochondrion.

Required for mitochondrial fusion as well as normal mitochondrial morphology by bridging the essential interaction between FZO1 and MGM1, May coordinate fusion of inner and outer membranes during mitochondrial fusion


This is Small ribosomal subunit protein mS46 protein, from Baker's yeast, contains 361 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane

Belongs to the mitochondrion-specific ribosomal protein mS46 family


This is CAAX prenyl protease 2 protein, from Baker's yeast, contains 315 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Proteolytically removes the C-terminal three residues of farnesylated proteins, including the a-factor mating pheromone and RAS


This is Ceramide synthase subunit LIP1 protein, from Baker's yeast, contains 150 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the ceramide synthase complex required for synthesis of ceramides


This is Inheritance of peroxisomes protein 1 protein, from Baker's yeast, contains 420 amino acids, is membrane-bound, locates in Peroxisome.


This is Inner nuclear membrane protein SRC1 protein, from Baker's yeast, contains 834 amino acids, is membrane-bound, locates in Nucleus.

Plays a role in sister chromatid separation


This is Non-structural maintenance of chromosome element 5 protein, from Baker's yeast, contains 556 amino acids, locates in Nucleus.

Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage, Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks


This is Transcription initiation factor TFIID subunit 8 protein, from Baker's yeast, contains 510 amino acids, locates in Nucleus.

Functions as a component of the DNA-binding general transcription factor complex TFIID, Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation, TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription


This is SPS-sensor component SSY1 protein, from Baker's yeast, contains 852 amino acids, is membrane-bound, locates in Cell membrane.

Amino acid sensor component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2, Amino-acid permease homolog that seems to interact directly with the extracellular signaling molecules, but has no amino acid transporter activity, May recruit casein kinases YCK1 and YCK2 to hyperphosphorylate and activate downstream component PTR3 in response to amino acid stimulus

Belongs to the amino acid-polyamine-organocation (APC) superfamily


This is 56 kDa U1 small nuclear ribonucleoprotein component protein, from Baker's yeast, contains 492 amino acids, locates in Nucleus.

Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA, Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway


This is Inheritance of peroxisomes protein 2 protein, from Baker's yeast, contains 705 amino acids, is membrane-bound, locates in Peroxisome.

Required for peroxisome inheritance, Acts as the peroxisome-specific receptor for the myosin V motor MYO2


This is AP-1-like transcription factor YAP6 protein, from Baker's yeast, contains 383 amino acids, locates in Nucleus.

Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements, According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, protein synthesis, carbohydrate metabolism, and carbohydrate transport, It may also be involved in pleiotropic drug resistance, When overexpressed, it confers resistance to cisplatin, methylmethanosulfonate, and mitomycin C, and increases cellular tolerance to sodium and lithium

Belongs to the bZIP family, YAP subfamily


This is Phosducin-like protein 1 protein, from Baker's yeast, contains 230 amino acids, is soluble, locates in Cytoplasm.

Not essential for growth, Inhibits early G-protein signaling events following pheromone stimulation, May help create heterodimerizable beta-tubulin by facilitating the efficient transfer of nascent beta-tubulin polypeptides to the folding apparatus


This is Transcriptional activator ARO80 protein, from Baker's yeast, contains 950 amino acids, locates in Nucleus.

Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10


This is Sensitive to high expression protein 9, mitochondrial protein, from Baker's yeast, contains 456 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the maintenance of the structure of the mitochondrial inner membrane, Involved in mitochondrial morphology, Causes growth arrest when highly overexpressed


This is Eisosome protein SEG1 protein, from Baker's yeast, contains 960 amino acids, is membrane-bound, locates in Cell membrane.

Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations, Required for efficient incorporation of the eisosome component PIL1 into eisosomes


This is Bud site selection protein 22 protein, from Baker's yeast, contains 519 amino acids, locates in Nucleus.

Involved in positioning the proximal bud pole signal


This is ADP-ribosylation factor GTPase-activating protein effector protein 1 protein, from Baker's yeast, contains 482 amino acids, has 1 C4-type Zinc finger, is soluble, locates in Cytoplasm.

GTPase-activating protein (GAP) for the ADP ribosylation factors ARF1 and ARF2, May be involved in the endocytic pathway


This is Protein IVY1 protein, from Baker's yeast, contains 453 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

May be required for vacuolar fusion, Overexpression leads to fragmentation of vacuoles, missorting of the vacuolar enzyme carboxypeptidase Y (CPY) to the exterior of the cell and accumulation of multivesicular bodies inside the cell


This is Ribosome quality control complex subunit 1 protein, from Baker's yeast, contains 723 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23178123, PubMed:27129255), Within the RQC complex, RQC1 is essential for the recruitment of CDC48 to incompletely synthesized nascent polypeptides that are ubiquitinated by RKR1/LTN1 (PubMed:23479637, PubMed:27129255)


This is rRNA-processing protein FCF1 protein, from Baker's yeast, contains 189 amino acids, locates in Nucleus.

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly, Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites

Belongs to the UTP23/FCF1 family, FCF1 subfamily


This is Protein PAL1 protein, from Baker's yeast, contains 499 amino acids, is membrane-bound, locates in Cell membrane.

Involved in the early step of endocytosis


This is Regulator of Ty1 transposition protein 103 protein, from Baker's yeast, contains 409 amino acids, locates in Nucleus.

Involved in transcription termination by RNA polymerase II and in regulation of Ty1 transposition


This is Cell wall biogenesis protein NCW2 protein, from Baker's yeast, contains 254 amino acids, is membrane-bound, locates in Cell membrane.

Cell wall biogenesis protein that participates in the organization of the beta-glucan assembly (PubMed:27246500), Involved in the mechanism responsible for cell tolerance to polyhexamethylene biguanide (PHMB), an antifungal agent (PubMed:27246500)


This is Cell division cycle protein 123 protein, from Baker's yeast, contains 360 amino acids, is soluble, locates in Cytoplasm.

Regulates the cell cycle in a nutrient dependent manner, Accumulates in presence of nutrients and directs the destabilization of DMA1 and DMA2, whose accumulation results in a G1 block, Regulates also the abundance of GCD11 an essential component of the translational initiation factor 2


This is Cytochrome oxidase assembly factor 4 protein, from Baker's yeast, contains 96 amino acids, is membrane-bound, locates in Mitochondrion.

Involved in cytochrome c oxidase assembly or stability


This is Protein N-terminal and lysine N-methyltransferase EFM7 protein, from Baker's yeast, contains 261 amino acids, is soluble, locates in Cytoplasm.

S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha (TEF1 and TEF2), before also catalyzing the mono- and dimethylation of 'Lys-3' (PubMed:21858014, PubMed:26545399), May be involved in rDNA silencing and in lifespan determination (PubMed:12736687)

Belongs to the class I-like SAM-binding methyltransferase superfamily, EFM7 family


This is MIOREX complex component 2 protein, from Baker's yeast, contains 277 amino acids, locates in Mitochondrion.

Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707), Component of a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis (PubMed:25631044)


This is Ribosome assembly protein 3 protein, from Baker's yeast, contains 220 amino acids, locates in Nucleus.

Required for efficient biogenesis of the 60S ribosomal subunit


This is Large ribosomal subunit protein mL43 protein, from Baker's yeast, contains 140 amino acids, locates in Mitochondrion.

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain, The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable), Also has an extraribosomal function, being essential for mitochondrial genome integrity, May interact with MHR1 to take part in the mtDNA repair mechanism (PubMed:25609543)

Belongs to the mitochondrion-specific ribosomal protein mL43 family


This is Pre-mRNA-splicing factor SNT309 protein, from Baker's yeast, contains 175 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing by stabilizing the NTC (or PRP19-associated complex), As a component of the NTC complex, associates to the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation


This is Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W protein, from Baker's yeast, contains 509 amino acids, is soluble, locates in Cytoplasm.

Synthesis and degradation of fructose 2,6-bisphosphate

In the C-terminal section; belongs to the phosphoglycerate mutase family


This is Inner kinetochore subunit NKP2 protein, from Baker's yeast, contains 153 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly


This is Mitochondrial inner membrane protein SHH4 protein, from Baker's yeast, contains 168 amino acids, is membrane-bound, locates in Mitochondrion.

Homolog of SDH4, but seems not to be a stoichiometric subunit of either the succinate dehydrogenase (SDH) complex or the mitochondrial inner membrane translocase TIM22 complex


This is Biogenesis of lysosome-related organelles complex 1 subunit CNL1 protein, from Baker's yeast, contains 122 amino acids, is soluble, locates in Cytoplasm.

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting


This is E3 ubiquitin-protein ligase MAG2 protein, from Baker's yeast, contains 670 amino acids, has 1 RING-type Zinc finger, is soluble, locates in Cytoplasm.

RING-type

E3 ubiquitin-protein ligase involved in the degradation of non-functional 18S rRNAs in response to stalled ribosomes (PubMed:30893611), Catalyzes monoubiquitination of RPS3/uS3 in response to stalled ribosomes, initiating a HEL2-dependent response that activates the degradation of non-functional 18S rRNAs (PubMed:30893611)


This is Polyamine transporter 3 protein, from Baker's yeast, contains 622 amino acids, is membrane-bound, locates in Cell membrane.

Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm, Recognizes spermine, but not spermidine

Belongs to the major facilitator superfamily, DHA1 family, Polyamines/proton antiporter (TC 2,A,1,2,16) subfamily


This is Peroxisomal adenine nucleotide transporter 1 protein, from Baker's yeast, contains 328 amino acids, is membrane-bound, locates in Peroxisome.

Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen, This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol, Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids, Required for growth on medium-chain fatty acids, pH gradient formation in peroxisomes and for normal peroxisome proliferation

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Ribosomal RNA-processing protein 15 protein, from Baker's yeast, contains 250 amino acids, locates in Nucleus.

Constituent of pre-60S ribosomal particles, Required for large subunit rRNA maturation, in particular processing of the 27S pre-rRNA at the A3 and B1 sites to yield 5,8S and 25S rRNA


This is Pre-mRNA-splicing factor URN1 protein, from Baker's yeast, contains 465 amino acids, locates in Nucleus.

Component of the spliceosome involved in mRNA processing


This is ABC1 family protein MCP2 protein, from Baker's yeast, contains 569 amino acids, is membrane-bound, locates in Mitochondrion.

Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression (PubMed:25683707), Involved in mitochondrial lipid homeostasis (PubMed:23781023)

Belongs to the protein kinase superfamily, ADCK protein kinase family


This is Aquaporin PIP1-2 protein, from Mouse-ear cress, contains 286 amino acids, is membrane-bound, locates in Cell membrane.

Water channel required to facilitate the transport of water across cell membrane, Essential for the water permeability of the plasma membrane and for the morphology of the root system, Its function is impaired by Hg(2+), Inhibited by cytosolic acidosis which occurs during anoxia in roots

Belongs to the MIP/aquaporin (TC 1,A,8) family, PIP (TC 1,A,8,11) subfamily


This is Inositol-pentakisphosphate 2-kinase protein, from Baker's yeast, contains 281 amino acids, locates in Nucleus.

Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate


This is Methyltransferase OMS1, mitochondrial protein, from Baker's yeast, contains 471 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial methyltransferase which suppresses respiratory defects caused by OXA1 mutations when overexpressed

Belongs to the methyltransferase superfamily, METL family


This is Putative ATP-dependent helicase IRC3 protein, from Baker's yeast, contains 689 amino acids, locates in Mitochondrion.

Belongs to the helicase family, IRC3 subfamily


This is Alcohol-sensitive RING finger protein 1 protein, from Baker's yeast, contains 288 amino acids, has 1 RING-type 1; atypical Zinc finger, has 1 RING-type 2; degenerate Zinc finger, locates in Cytoplasm.

RING-type 1; atypical

RING-type 2; degenerate


This is Pre-mRNA-splicing factor RDS3 protein, from Baker's yeast, contains 107 amino acids, locates in Nucleus.

Required for pre-mRNA splicing, Involved in regulation of drug sensitivity and may play a role in multidrug resistance


This is NADH kinase POS5, mitochondrial protein, from Baker's yeast, contains 414 amino acids, is soluble, locates in Mitochondrion.

Phosphorylates both NADH and NAD(+), with a twofold preference for NADH, Anti-oxidant factor and key source of the cellular reductant NADPH


This is Protein PUN1 protein, from Baker's yeast, contains 263 amino acids, is membrane-bound, locates in Cell membrane.

Contributes to the wild-type cellular response to nitrogen stress through signaling pathways that regulate the expression of genes involved in amino acid biosynthesis, Required for wild-type filamentous growth, cell growth, and cell-cell adhesion


This is Kinetoplast-associated protein 4 protein, from Crithidia fasciculata, contains 128 amino acids, is soluble, locates in Mitochondrion.

Histone H1-like DNA-binding protein involved in the organization and segregation of kinetoplast DNA (kDNA), The mitochondrial DNA of kinetoplastid protozoa consists of about 5,000 minicircles and 20 to 30 maxicircles, These circular DNAs are held together by catenation into a highly organized compact disk structure referred to as a kinetoplast DNA (kDNA) network, Binds preferentially to a specific fragment of minicircle DNA and is able to compact kDNA networks through DNA charge neutralization and condensation


This is Transcriptional regulatory protein RXT3 protein, from Baker's yeast, contains 294 amino acids, locates in Nucleus.

Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


This is Formate dehydrogenase, mitochondrial protein, from Potato, contains 381 amino acids, locates in Mitochondrion.

Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide (PubMed:8278546), Involved in the cell stress response, Involved in formate-dependent oxygen uptake coupled to ATP synthesis (PubMed:9490763)

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family, FDH subfamily


This is Mitochondrial glycine transporter protein, from Baker's yeast, contains 307 amino acids, is membrane-bound, locates in Mitochondrion.

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix, Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix

Belongs to the mitochondrial carrier (TC 2,A,29) family, SLC25A38 subfamily


This is Nucleolar protein 6 protein, from Baker's yeast, contains 225 amino acids, locates in Nucleus.

Predicted to be involved in rRNA processing


This is Mesoderm-specific transcript protein protein, from Mouse, contains 335 amino acids, is membrane-bound, locates in Endoplasmic reticulum.


This is SUR7 family protein FMP45 protein, from Baker's yeast, contains 309 amino acids, is membrane-bound, locates in Cell membrane.

Involved in sporulation and affects the sphingolipid composition of the plasma membrane


This is Probable guanine deaminase protein, from Baker's yeast, contains 489 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

Belongs to the metallo-dependent hydrolases superfamily, ATZ/TRZ family


This is Galectin-3-binding protein protein, from Mouse, contains 577 amino acids, is soluble, locates in Extracellular.

Promotes integrin-mediated cell adhesion, May stimulate host defense against viruses and tumor cells (By similarity)


This is ELMO family protein LMO1 protein, from Baker's yeast, contains 665 amino acids, is soluble, locates in Cytoplasm.

Forms a transiant heterodimeric complex with DCK1, that acts as a guanine nucleotide exchange factor (GEF) for the small GTPase RHO5 (PubMed:25598154), DCK1, LMO1 and RHO5 relocate to mitochondria upon oxidative stress and trigger cell death (PubMed:25598154), The DCK1/LMO1/RHO5 signaling module mediates mitochondrial turnover under nitrogen starvation conditions via mitophagy (PubMed:25598154), The DCK1/LMO1/RHO5 signaling module also plays a role in cell wall integrity signaling (PubMed:25598154)


This is Putative Xaa-Pro aminopeptidase FRA1 protein, from Baker's yeast, contains 749 amino acids, is soluble, locates in Cytoplasm.

Involved in the regulation of the iron regulon in responss to decreased mitochondrial iron-sulfur cluster synthesis


This is Chromatin structure-remodeling complex protein RSC58 protein, from Baker's yeast, contains 502 amino acids, locates in Nucleus.

Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning, RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA, The reaction requires ATP and involves an activated RSC-nucleosome intermediate, Remodeling reaction also involves DNA translocation, DNA twist and conformational change, As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton


This is DNA mismatch repair protein MLH2 protein, from Baker's yeast, contains 695 amino acids, locates in Nucleus.

Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis, Component of a MutL heterodimer with MLH1, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches, This complex is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis, Plays a role in the repair of heteroduplex sites present in meiotic recombination intermediates and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates

Belongs to the DNA mismatch repair MutL/HexB family


This is Coenzyme Q-binding protein COQ10, mitochondrial protein, from Baker's yeast, contains 207 amino acids, is membrane-bound, locates in Mitochondrion.

Required for the function of coenzyme Q in the respiratory chain, May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes


This is Mitochondrial import protein 1 protein, from Baker's yeast, contains 113 amino acids, is membrane-bound, locates in Mitochondrion.

Component of the MIM complex required for mitochondrial outer membrane protein import (PubMed:22467864), The MIM complex cooperates with the receptor TOM70 in binding of precursor proteins and promotes their insertion and assembly into the outer membrane (PubMed:21825073), Involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including UGO1 (PubMed:21825073, PubMed:21825074), Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:15242642, PubMed:15326197, PubMed:15608614), Required specifically for assembly of TOM40, TOM20, and TOM70, but not TOM22 (PubMed:17974559, PubMed:18187149)


This is Nucleolar protein 12 protein, from Baker's yeast, contains 459 amino acids, locates in Nucleus.


This is RNA exonuclease 4 protein, from Baker's yeast, contains 289 amino acids, locates in Nucleus.

Exoribonuclease involved in ribosome biosynthesis, Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5,8S rRNAs


This is Ino eighty subunit 4 protein, from Baker's yeast, contains 116 amino acids, locates in Nucleus.


This is Peroxisomal membrane protein PEX27 protein, from Baker's yeast, contains 376 amino acids, is membrane-bound, locates in Peroxisome.

Required for regulation of peroxisome size and number, Also promotes peroxisome division and biogenesis


This is Genetic interactor of prohibitins 3, mitochondrial protein, from Baker's yeast, contains 556 amino acids, locates in Mitochondrion.

Interacts genetically with prohibitins and thus may be involved in the mitochondrial lipid metabolism

Belongs to the TRAFAC class YlqF/YawG GTPase family, GEP3 subfamily


This is GPN-loop GTPase 2 protein, from Baker's yeast, contains 347 amino acids, is soluble, locates in Cytoplasm.

Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII), May act at an RNAP assembly step prior to nuclear import (PubMed:23267056), Required for establishment of sister chromatid cohesion (PubMed:18439903)


This is Serine/threonine-protein kinase HRK1 protein, from Baker's yeast, contains 759 amino acids, is soluble, locates in Cytoplasm.

Involved in regulating the activity of the plasma membrane proton pump PMA1

Belongs to the protein kinase superfamily, Ser/Thr protein kinase family


This is Regulator of ribosome biosynthesis protein, from Baker's yeast, contains 203 amino acids, locates in Nucleus.


This is Leucine-rich repeat-containing protein SOG2 protein, from Baker's yeast, contains 791 amino acids, is soluble, locates in Cytoplasm.

Required for proper cell morphogenesis and cell separation after mitosis, Functions in the RAM (regulation of ACE2 activity and cellular morphogenesis) signaling network and is required for proper ACE2 localization and CBK1 kinase activity


This is Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial protein, from Baker's yeast, contains 631 amino acids, is membrane-bound, locates in Mitochondrion.

Accepts electrons from ETF and reduces ubiquinone


This is Transgelin protein, from Baker's yeast, contains 200 amino acids, is soluble, locates in Cytoplasm.

Has actin-binding and actin-bundling activity, Stabilizes actin filaments against disassembly


This is Formate dehydrogenase 1 protein, from Baker's yeast, contains 376 amino acids, is soluble, locates in Cytoplasm.

Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide, Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms (PubMed:9178506, PubMed:12144528, PubMed:11921099), Has a role in the detoxification of exogenous formate in non-methylotrophic organisms (PubMed:11921099)


This is Ubiquitin carboxyl-terminal hydrolase MIY1 protein, from Baker's yeast, contains 360 amino acids, is soluble, locates in Cytoplasm.

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins, Has endodeubiquitinase activity

Belongs to the MINDY deubiquitinase family, FAM63 subfamily


This is U2 small nuclear ribonucleoprotein A' protein, from Baker's yeast, contains 238 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing, Associates to U2 snRNA in a MSL1 dependent manner and is required for normal accumulation of U2 snRNA, Required for the spliceosome assembly and the efficient addition of U2 snRNP onto the pre-mRNA

Belongs to the U2 small nuclear ribonucleoprotein A family


This is Protamine-like protein protein, from Striped red mullet, contains 178 amino acids, locates in Nucleus.

Replaces histones in the chromatin of sperm during the haploid phase of spermatogenesis, Compacts sperm DNA into a highly condensed, stable and inactive complex


This is Hibernation-specific plasma protein HP-55 protein, from Siberian chipmunk, contains 413 amino acids, is soluble, locates in Extracellular.


This is Alpha-1,2-galactosyltransferase protein, from Fission yeast, contains 375 amino acids, is membrane-bound, locates in Golgi apparatus.

Involved in the O- and N-linked oligosaccharide modification of proteins transported through the Golgi stack, This occurs in cis Golgi where the enzyme transfers galactose from UDP-galactose to a variety of mannose based acceptors

Belongs to the glycosyltransferase 34 family


This is Adenylate kinase isoenzyme 6 homolog protein, from Caenorhabditis elegans, contains 182 amino acids, locates in Nucleus.

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates, AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates, ATP and dATP are the best phosphate donors, May have a role in nuclear energy homeostasis

Belongs to the adenylate kinase family, AK6 subfamily


This is Alcohol dehydrogenase 4 protein, from Fission yeast, contains 422 amino acids, is soluble, locates in Mitochondrion.

Involved in ethanol oxidation in mitochondria

Belongs to the iron-containing alcohol dehydrogenase family


This is Transcriptional repressor tup11 protein, from Fission yeast, contains 614 amino acids, locates in Nucleus.


This is ATP-dependent RNA helicase dbp10 protein, from Fission yeast, contains 848 amino acids, locates in Nucleus.

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5,8S rRNAs

Belongs to the DEAD box helicase family, DDX54/DBP10 subfamily


This is Eukaryotic translation initiation factor 3 subunit M protein, from Fission yeast, contains 402 amino acids, is soluble, locates in Cytoplasm.

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome, The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation


This is Multidrug resistance protein fnx1 protein, from Fission yeast, contains 531 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Efflux transporter, Confers resistance to a variety of toxic compounds

Belongs to the major facilitator superfamily


This is Small ribosomal subunit protein uS4A protein, from Fission yeast, contains 191 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell, The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules, The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain, The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel, uS4 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly

Belongs to the universal ribosomal protein uS4 family


This is Cullin-3 protein, from Fission yeast, contains 785 amino acids, is soluble, locates in Cytoplasm.

Probable core component of multiple cullin-RING-based BC3B (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme, The functional specificity of the BC3B complex depends on the substrate recognition component (By similarity), Involved in ubiquitin-mediated degradation of btb3


This is DNA replication regulator sld3 protein, from Fission yeast, contains 699 amino acids, locates in Nucleus.

Required for loading and maintenance of stable association of cdc45 with chromatin during initiation and elongation of DNA replication, Also involved in temporal regulation of origin firing, Plays a role in meiosis


This is ATP-dependent helicase upf1 protein, from Fission yeast, contains 925 amino acids, is soluble, locates in Cytoplasm.

RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (By similarity), Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (By similarity)

Belongs to the DNA2/NAM7 helicase family


This is F-box/WD repeat-containing protein pof11 protein, from Fission yeast, contains 506 amino acids, is soluble, locates in Cytoplasm.


This is Peptidyl-prolyl cis-trans isomerase cyp8 protein, from Fission yeast, contains 516 amino acids, locates in Nucleus.

May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins, May also function as a chaperone, playing a role in intracellular transport of proteins, May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins

Belongs to the cyclophilin-type PPIase family, PPIL2 subfamily


This is Cyclin-B2-2 protein, from Rice, contains 419 amino acids, locates in Nucleus.

Involved in the control of the cell cycle at the G2/M (mitosis) transition, May associate to CDKB2-1 and activate CDKB2-1 kinase activity to promote cell division

Belongs to the cyclin family, Cyclin AB subfamily


This is Transcription factor ILI6 protein, from Rice, contains 92 amino acids, locates in Nucleus.

Atypical and probable non DNA-binding bHLH transcription factor that acts as a positive regulator of grain size, Binds the transcription repressor APG and forms a heterodimer of antagonistic bHLH transcription factors that regulates grain length and weight by controlling cell elongation in lemma and palea, May be involved in the control of lamina inclination through brassinosteroid signaling pathway


This is Chaperone protein ClpB3, mitochondrial protein, from Rice, contains 983 amino acids, locates in Mitochondrion.

Molecular chaperone that may not be involved in heat stress response or tolerance


This is Metal transporter CNNM1 protein, from Mouse, contains 951 amino acids, is membrane-bound, locates in Cell membrane.


This is Methyl-CpG-binding domain protein 4-like protein protein, from Mouse-ear cress, contains 445 amino acids, locates in Nucleus.

Monofunctional DNA glycosylase targeting U:G and T:G mispairs (PubMed:23994068), Excises uracil derivatives and exhibits a preference for a CpG sequence context, irrespective of the methylation status of the complementary strand (PubMed:23994068), The activity follows a biphasic kinetics, with an initial burst of product accumulation followed by a slower phase (PubMed:23994068), Specifically binds its reaction product (PubMed:23994068), Triggers the base excision repair (BER) pathway (PubMed:25900572)


This is Probable transcription factor RL9 protein, from Rice, contains 532 amino acids, locates in Nucleus.

Probable transcription factor that regulates abaxial identity during leaf development (PubMed:18594992), Modulates leaf rolling by regulating the programmed cell death (PCD) of abaxial mesophyll and sclerenchyma cells during leaf development (PubMed:19304938)


This is Protein LSD1 protein, from Rice, contains 184 amino acids, locates in Nucleus.

Negative regulator of programmed cell death and hypersensitive response (HR), Positive regulator of callus differentiation


This is Protein YABBY 5 protein, from Rice, contains 266 amino acids, has 1 C4-type Zinc finger, locates in Nucleus.

May be involved in leaf cell growth and differentiation, rather than abaxial cell fate determination


This is cAMP-responsive element-binding protein-like 2 protein, from Bovine, contains 120 amino acids, locates in Nucleus.

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation, May also play a regulatory role in the cell cycle

Belongs to the bZIP family, ATF subfamily


This is Heat shock 70 kDa protein 14 protein, from Human, contains 509 amino acids, is soluble, locates in Cytoplasm.

Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state, In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity

Belongs to the heat shock protein 70 family


This is Probradykinin-2 protein, from Orange-legged monkey tree frog, contains 61 amino acids, is soluble, locates in Extracellular.

May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity), May target bradykinin receptors (BDKRB)

Belongs to the frog skin active peptide (FSAP) family, Bradykinin-related peptide subfamily


This is Phyllokinin-1 protein, from Orange-legged monkey tree frog, contains 62 amino acids, is soluble, locates in Extracellular.

Inhibits ACE with a Ki of 1,6 uM, and targets B2 bradykinin receptor (BDKRB2), Provokes contraction of smooth muscle preparation (ileum), In vivo, induces an early hyperalgesic effects in living rats after intraplantar injection (By similarity)


This is Probradykinin-1 protein, from Orange-legged monkey tree frog, contains 61 amino acids, is soluble, locates in Extracellular.


This is Phylloseptin-H9 protein, from Orange-legged leaf frog, contains 66 amino acids, is soluble, locates in Extracellular.

Belongs to the frog skin active peptide (FSAP) family, Phylloseptin subfamily


This is Phylloseptin-H8 protein, from Orange-legged leaf frog, contains 66 amino acids, is soluble, locates in Extracellular.


This is Phylloseptin-H7 protein, from Orange-legged leaf frog, contains 66 amino acids, is soluble, locates in Extracellular.


This is Auxilin-related protein 2 protein, from Mouse-ear cress, contains 891 amino acids, is soluble, locates in Cytoplasm.

Promotes probably uncoating of clathrin-coated vesicles


This is Dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial protein, from Mouse-ear cress, contains 637 amino acids, is soluble, locates in Mitochondrion.

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Belongs to the 2-oxoacid dehydrogenase family


This is RHOMBOID-like protein 1 protein, from Mouse-ear cress, contains 389 amino acids, is membrane-bound, locates in Golgi apparatus.

Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis, Unable to cleave the Drosophila protein Spitz


This is GDSL esterase/lipase EXL4 protein, from Mouse-ear cress, contains 343 amino acids, is soluble, locates in Extracellular.

Required for the formation of pollen coats and male fertility

Belongs to the 'GDSL' lipolytic enzyme family


This is MEF2-activating motif and SAP domain-containing transcriptional regulator protein, from Mouse, contains 421 amino acids, locates in Nucleus.

Transcriptional coactivator, Stimulates the transcriptional activity of MEF2C, Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation


This is Probable splicing factor, arginine/serine-rich 5 protein, from Caenorhabditis elegans, contains 208 amino acids, locates in Nucleus.

Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites

Belongs to the splicing factor SR family


This is Heat shock protein 70 homolog lhs1 protein, from Fission yeast, contains 848 amino acids, is soluble, locates in Endoplasmic reticulum.

Chaperone required for protein translocation and folding in the endoplasmic reticulum


This is Serine hydroxymethyltransferase, mitochondrial protein, from Fission yeast, contains 488 amino acids, locates in Mitochondrion.


This is Manganese transporter pdt1 protein, from Fission yeast, contains 521 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Transports manganese ions into the cell, Regulates cell morphogenesis through control of manganese homeostasis


This is Ras modification protein erf4 protein, from Fission yeast, contains 172 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

The erf2-erf4 complex is a palmitoyltransferase with a major role in driving sexual development (PubMed:23843742, PubMed:16303567), Palmitoylates ras1 (PubMed:23843742), Palmitoylates isp3 (PubMed:23843742), Palmitoylates rho3 (PubMed:23843742)


This is RNA polymerase I-specific transcription initiation factor RRN9 homolog protein, from Fission yeast, contains 250 amino acids, locates in Nucleus.

Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and is required for the proper accumulation of rpa1/nuc1 at rDNAs, Required for nucleolar localization of condensin


This is Spindle pole body protein ppc89 protein, from Fission yeast, contains 783 amino acids, is soluble, locates in Cytoplasm.


This is BTB/POZ domain-containing protein 3 protein, from Fission yeast, contains 523 amino acids, is soluble, locates in Cytoplasm.

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins


This is Cell polarity protein alp11 protein, from Fission yeast, contains 234 amino acids, is soluble, locates in Cytoplasm.

Required for microtubule function and cell polarity, Involved in the proper folding of alpha-tubulin


This is Pre-rRNA-processing protein crb3/ipi3 protein, from Fission yeast, contains 446 amino acids, locates in Nucleus.

Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA

Belongs to the WD repeat IPI3/WDR18 family


This is Cell polarity protein alp21 protein, from Fission yeast, contains 511 amino acids, is soluble, locates in Cytoplasm.

Required for microtubule and spindle assembly, Involved in the proper folding of alpha-tubulin


This is Transcription regulator complex subunit bur6 protein, from Fission yeast, contains 199 amino acids, locates in Nucleus.

Transcription regulator complex subunit that is essential for cell cycle progression


This is Uncharacterized ATP-dependent helicase C582.10c protein, from Fission yeast, contains 830 amino acids, locates in Nucleus.

Belongs to the SNF2/RAD54 helicase family


This is Superoxide dismutase 1 copper chaperone protein, from Fission yeast, contains 297 amino acids, is soluble, locates in Cytoplasm.

Copper chaperone for superoxide dismutase 1 (sod1), Binds copper ions and delivers them specifically to sod1, Also has a role in cell protection against copper ion toxicity during conditions of copper excess, The C-terminal region is thought to act specifically in this sequestration role


This is Electron transfer protein 1, mitochondrial protein, from Fission yeast, contains 616 amino acids, is membrane-bound, locates in Mitochondrion.


This is SET domain-containing protein 3 protein, from Fission yeast, contains 859 amino acids, has 1 PHD-type Zinc finger, locates in Nucleus.

PHD-type

Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin, Required for both gene activation and repression, Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis, Required for the transcriptional activation of genes with high activity (By similarity)

Belongs to the class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET3 subfamily


This is Transcription factor zip1 protein, from Fission yeast, contains 330 amino acids, locates in Nucleus.

Mediates cell growth arrest in response to cadmium exposure, which is essential to maintain cell viability, Regulates cadmium stress specific genes


This is Nuclear/nucleolar GTPase 2 protein, from Rice, contains 535 amino acids, locates in Nucleus.

GTPase involved in pre-60S ribosomal subunit maturation

Belongs to the TRAFAC class YlqF/YawG GTPase family, RsgA subfamily


This is Neutral/alkaline invertase 1, mitochondrial protein, from Rice, contains 628 amino acids, locates in Mitochondrion.

Mitochondrial invertase that cleaves sucrose into glucose and fructose

Belongs to the glycosyl hydrolase 100 family


This is Translation machinery-associated protein 46 protein, from Baker's yeast, contains 345 amino acids, has 2 C3H1-type Zinc finger, is soluble, locates in Cytoplasm.


This is DSC E3 ubiquitin ligase complex subunit 3 protein, from Baker's yeast, contains 292 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Component of the DSC E3 ubiquitin ligase complexes that tag proteins present in Golgi, endosome and vacuole membranes and function in protein homeostasis under non-stress conditions and support a role in protein quality control (PubMed:25078903, PubMed:29355480), Involved in endocytic protein trafficking (PubMed:21777356)


This is Endoplasmic reticulum membrane protein complex subunit 10 protein, from Baker's yeast, contains 205 amino acids, locates in Endoplasmic reticulum.

Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29809151), Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29809151), Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151), It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes, By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins (By similarity)


This is Mitochondrial 2-methylisocitrate lyase ICL2 protein, from Baker's yeast, contains 575 amino acids, is soluble, locates in Mitochondrion.

Catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA, Does not act on isocitrate

Belongs to the isocitrate lyase/PEP mutase superfamily, Isocitrate lyase family


This is Protein THP3 protein, from Baker's yeast, contains 470 amino acids, locates in Nucleus.

Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation, May also be involved in pre-mRNA splicing


This is Iron sulfur cluster assembly protein 2, mitochondrial protein, from Baker's yeast, contains 156 amino acids, is soluble, locates in Mitochondrion.

Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins, First, a [2Fe-2S] cluster is transiently assembled on the scaffold proteins ISU1 and ISU2, In a second step, the cluster is released from ISU1/ISU2, transferred to glutaredoxin GRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins, Cluster assembly on ISU1/ISU2 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin (YFH1) as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase ARH1 and ferredoxin YAH1, which receive their electrons from NADH, Fe-S cluster release from ISU1/ISU2 is achieved by interaction with the Hsp70 chaperone SSQ1, assisted by the DnaJ-like co-chaperone JAC1 and the nucleotide exchange factor MGE1 (PubMed:23615440), ISU1 is the major isoform in yeast, while ISU2 is not detectable in cells grown to stationary phase (By similarity), ISU2 is the minor isoform in yeast and is not detectable in cells grown to stationary phase (PubMed:10588895), Also involved in production of a sulfur precursor required for thiolation of cytoplasmic tRNAs (PubMed:31040179)


This is Nuclear rim protein 1 protein, from Baker's yeast, contains 484 amino acids, is membrane-bound, locates in Nucleus.

Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability, Required for rDNA repeat stability


This is Transcriptional protein SWT1 protein, from Baker's yeast, contains 458 amino acids, locates in Nucleus.

Involved in transcription, Probably functions as a transcriptional activator


This is Golgi to ER traffic protein 4 protein, from Baker's yeast, contains 312 amino acids, is soluble, locates in Cytoplasm.

May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane


This is Signal peptidase complex subunit 3 protein, from Baker's yeast, contains 184 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:9148931, PubMed:9148930), Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (PubMed:9148931, PubMed:9148930), Essential for viability (PubMed:9148931, PubMed:9148930)


This is Kinetochore-associated protein NSL1 protein, from Baker's yeast, contains 216 amino acids, locates in Nucleus.

Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity, MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules, NSL1 facilitates the attachment of two of the DASH complex components, DAD2 and SPC19, to the kinetochore in a microtubule-dependent manner


This is Ribosome biogenesis protein SSF2 protein, from Baker's yeast, contains 453 amino acids, locates in Nucleus.

Required for biogenesis of the 60S ribosomal subunit


This is RING finger protein PSH1 protein, from Baker's yeast, contains 406 amino acids, has 1 RING-type Zinc finger, locates in Nucleus.

RING-type


This is NAP1-binding protein 2 protein, from Baker's yeast, contains 236 amino acids, is soluble, locates in Cytoplasm.

Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity, Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK), With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2


This is Putative endoplasmic reticulum mannosidase MNL2 protein, from Baker's yeast, contains 849 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

Putative mannosidase involved in glycoprotein quality control since it is involved in the targeting of misfolded glycoproteins for ER-associated protein degradation (ERAD)

Belongs to the glycosyl hydrolase 47 family


This is Uncharacterized protein SLP1 protein, from Baker's yeast, contains 587 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in membrane protein folding (PubMed:19325107), Required for localization of MPS3 to the nuclear envelope (PubMed:23275891)


This is GRIP domain-containing protein RUD3 protein, from Baker's yeast, contains 484 amino acids, is soluble, locates in Golgi apparatus.

Involved in the structural organization of the cis-Golgi and in vesicle targeting/fusion stages of ER to Golgi transport


This is Proteasome chaperone 4 protein, from Baker's yeast, contains 148 amino acids, is soluble, locates in Cytoplasm.

Involved in 20S proteasome assembly, facilitating the alpha-ring formation, Involved in maintenance of telomere length


This is Malonyl CoA-acyl carrier protein transacylase, mitochondrial protein, from Baker's yeast, contains 360 amino acids, locates in Mitochondrion.

Involved in biosynthesis of fatty acids in mitochondria


This is Protein MAM3 protein, from Baker's yeast, contains 706 amino acids, is membrane-bound, locates in Lysosome/Vacuole.

Involved in metal homeostasis and more specially in manganese sensitivity


This is Transcription factor tau 60 kDa subunit protein, from Baker's yeast, contains 588 amino acids, locates in Nucleus.

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements, Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function, Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes, Plays a role in TFIIB assembly through its interaction with SPT15/TBP, Essential for cell viability


This is Platinum sensitivity protein 3 protein, from Baker's yeast, contains 242 amino acids, locates in Nucleus.

Required for resistance to the DNA-damaging agents methyl methanesulfonate (MMS), cisplatin and oxaliplatin, but not to mitomycin C, Plays a role in protection against mutation accumulation, May be a component of the recombination-repair pathway


This is Ino eighty subunit 3 protein, from Baker's yeast, contains 250 amino acids, locates in Nucleus.

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex


This is Protein SFI1 protein, from Baker's yeast, contains 946 amino acids, is soluble, locates in Cytoplasm.

Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication


This is S-methylmethionine permease 1 protein, from Baker's yeast, contains 583 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source

Belongs to the amino acid-polyamine-organocation (APC) superfamily, YAT (TC 2,A,3,10) family


This is Mitochondrial ornithine transporter 1 protein, from Baker's yeast, contains 292 amino acids, is membrane-bound, locates in Mitochondrion.

Required for arginine biosynthesis, Transports ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol, where it is converted to arginine

Belongs to the mitochondrial carrier (TC 2,A,29) family


This is Pre-mRNA-splicing factor prp1 protein, from Fission yeast, contains 906 amino acids, locates in Nucleus.

Involved in pre-mRNA splicing, Interacts with prp6 and prp13, May also be involved in the regulation of the G0-G1/G2 transition, Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing, This protein is associated with snRNP U5, Has a role in branch site-3' splice site selection, Associates with the branch site-3' splice 3'-exon region


This is N-terminal acetyltransferase B complex subunit MDM20 protein, from Baker's yeast, contains 796 amino acids, is soluble, locates in Cytoplasm.

Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met, NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions, MDM20 is required for mitochondrial inheritance during budding and together with TPM1, is essential for the integrity and assembly of actin cables, Genetically interacts with CIN8


This is Peroxisomal membrane protein LPX1 protein, from Baker's yeast, contains 387 amino acids, is soluble, locates in Peroxisome.

Has acyl esterase, lipase and phospholipase A activity


This is Transcription factor tau 55 kDa subunit protein, from Baker's yeast, contains 435 amino acids, locates in Nucleus.

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements, Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function, Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes


This is 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component protein, from Baker's yeast, contains 587 amino acids, locates in Nucleus.

Component of the U4/U6,U5 tri-snRNP particle, one of the building blocks of the spliceosome, Required for pre-mRNA splicing


This is Polyamine N-acetyltransferase 1 protein, from Baker's yeast, contains 191 amino acids, is soluble, locates in Cytoplasm.

Acetylates spermine and probably also other polyamines such as putrescine or spermidine, May regulate the levels of polyamines on chromosomal DNA, which would modify chromatin structure and affect transcription or replication, Also able to acetylate arylalkylamines such as tryptamine and serotonin in vitro

Belongs to the acetyltransferase family, AANAT subfamily


This is Cytoplasmic export protein 1 protein, from Baker's yeast, contains 761 amino acids, is soluble, locates in Cytoplasm.

Component of the nuclear tRNA export machinery that my collect tRNA from the nuclear tRNA export receptors of the aminoacylation-dependent export and may deliver aminoacylated tRNAs to the translation machinery pathway at the nuclear pore complex


This is Inner kinetochore subunit NKP1 protein, from Baker's yeast, contains 238 amino acids, locates in Nucleus.

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis, Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly


This is UDP-galactose transporter homolog 1 protein, from Baker's yeast, contains 339 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen, Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum, Overexpression confers resistance to the immunosuppressive drug, leflunomide

Belongs to the nucleotide-sugar transporter family, SLC35B subfamily


This is Homocysteine S-methyltransferase 1 protein, from Baker's yeast, contains 324 amino acids, is soluble, locates in Cytoplasm.

Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio, Also converts S-methylmethionine (SMM) to methionine


This is Dihydrofolate synthetase protein, from Baker's yeast, contains 427 amino acids, is soluble, locates in Cytoplasm.

Glutamate-adding enzyme which catalyzes the binding of the first glutamyl side chain to dihydropteroate, Leads to the de nove synthesis of tetrahydrofolate

Belongs to the folylpolyglutamate synthase family


This is Endochitinase 33 protein, from Hypocrea lixii, contains 321 amino acids, is soluble, locates in Extracellular.

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods), Plays a morphogenetic role during apical growth, cell division and differentiation (cell wall morphogenesis), May be involved in the degradation and further assimilation of phytopathogenic fungi, namely mycoparasitism, the major mechanism accounting for the antagonistic activity against phytopathogenic fungi displayed by Trichoderma

Belongs to the glycosyl hydrolase 18 family, Chitinase class III subfamily


This is DER1-like family member protein 1 protein, from Baker's yeast, contains 341 amino acids, is membrane-bound, locates in Endoplasmic reticulum.

May be involved in the degradation process of some misfolded endoplasmic reticulum (ER) luminal proteins, Its precise role is however unclear and its inability to complement der1 mutations, suggests either that it is not involved in degradation process of misfolded proteins, or that it participates in the destruction of specific misfolded ER luminal proteins


This is RNA polymerase II assembly factor RTP1 protein, from Baker's yeast, contains 981 amino acids, is soluble, locates in Cytoplasm.

Required for the cytoplasmic assembly and the nuclear import of RNA polymerase II, May facilitate the starting interaction between RNA polymerase II subunits RPB2 and RPB3 and the subsequent interaction of the resulting complex with subunit RPB1, May also participate in the transport of RNA polymerase II through the nuclear pore complex


This is Transcriptional activator HAA1 protein, from Baker's yeast, contains 694 amino acids, locates in Nucleus.

Regulates the transcription of a set of genes, many of which encode membrane proteins, Among the genes regulated are YGR138C and YRO2, Does not seem to be dependent on copper


This is Adipogenesis regulatory factor protein, from Human, contains 76 amino acids, locates in Nucleus.

Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation, Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin


This is Probable prefoldin subunit 1 protein, from Caenorhabditis elegans, contains 117 amino acids, is soluble, locates in Cytoplasm.

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it, Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity), Has a role in gonadogenesis

Belongs to the prefoldin subunit beta family


This is Suppressor of presenilin-2 protein, from Caenorhabditis elegans, contains 312 amino acids, locates in Nucleus.

Potential corepressor protein, which may affect chromatin structure and/or transcription, May participate in the transcriptional repression of the presenilin protein hop-1

Belongs to the nucleosome assembly protein (NAP) family


This is ADP-ribosylation factor-like protein 6 protein, from Caenorhabditis elegans, contains 190 amino acids, is soluble, locates in Cytoplasm.

Belongs to the small GTPase superfamily, Arf family


This is REST corepressor spr-1 protein, from Caenorhabditis elegans, contains 558 amino acids, has 1 GATA-type Zinc finger, locates in Nucleus.

GATA-type

Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1 (PubMed:12381669), Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones (PubMed:12381669), Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation (PubMed:17070797)


This is Glutathione s-transferase kappa 2 protein, from Caenorhabditis elegans, contains 225 amino acids, locates in Mitochondrion.

Has roles in respiratory and lipid metabolism

Belongs to the GST superfamily, Kappa family


This is Homogentisate solanesyltransferase, chloroplastic protein, from Mouse-ear cress, contains 386 amino acids, is membrane-bound, locates in Plastid.

Involved in the synthesis of plastoquinone-9, Can use both homogentisic acid and 2,5-dihydroxyphenylacetic acid gamma-lactone as prenyl acceptors, and solanesyl diphosphate > farnesyl diphosphate > geranylgeranyl diphosphate >> phytyl diphosphate as prenyl donors, Do not catalyze the decardoxylation of homogentisate uncoupled from prenylation

Belongs to the UbiA prenyltransferase family


This is M-zodatoxin-Lt1a protein, from Spider, contains 88 amino acids, is soluble, locates in Extracellular.

Has antimicrobial activity against Gram-positive bacteria (A,globiformis VKM Ac-1112 (MIC=0,5 uM), and B,subtilis VKM B-501 (MIC=1,0 uM)), Gram-negative bacteria (E,coli DH5-alpha (MIC=1,0 uM), E,coli MH1 (MIC=0,7 uM), and P,aeruginosa PAO1 (MIC=4,1 uM)), and yeasts (P,pastoris GS115 (MIC=17 uM), and S,cerevisiae Y190 (MIC>33 uM)), Has a moderate hemolytic activity against rabbit erythrocytes, Causes paralysis, but is not lethal when injected into insect (M,domestica) larvae

Belongs to the cationic peptide 03 (latarcin) family, 01 subfamily


This is M-zodatoxin-Lt2a protein, from Spider, contains 84 amino acids, is soluble, locates in Extracellular.

It has antimicrobial activity against Gram-positive bacteria (A,globiformis VKM Ac-1112 (MIC=0,7 uM), and B,subtilis VKM B-501 (MIC=0,4 uM)), Gram-negative bacteria (E,coli DH5-alpha (MIC=1,0 uM), E,coli MH1 (MIC=0,7 uM), and P,aeruginosa PAO1 (MIC=6,7 uM)), and yeasts (P,pastoris GS115 (MIC=6,7 uM), and S,cerevisiae Y190 (MIC=54 uM)), Also has a strong hemolytic activity against rabbit erythrocytes, Causes paralysis, but is not lethal when injected into insect (M,domestica) larvae

Belongs to the cationic peptide 03 (latarcin) family, 02 subfamily


This is M-zodatoxin-Lt3b protein, from Spider, contains 82 amino acids, is soluble, locates in Extracellular.

It has antimicrobial activity against Gram-positive bacteria (A,globiformis VKM Ac-1112 (MIC=0,7 uM), and B,subtilis VKM B-501 (MIC=2,9 uM)), Gram-negative bacteria (E,coli DH5-alpha (MIC=23 uM), E,coli MH1 (MIC=28 uM), and P,aeruginosa PAO1 (MIC>45 uM)), and yeasts (P,pastoris GS115 (MIC=23 uM), and S,cerevisiae Y190 (MIC=23 uM)), Does not have hemolytic against rabbit erythrocytes, Causes paralysis, but is not lethal when injected into insect (M,domestica) larvae

Belongs to the cationic peptide 03 (latarcin) family, 03 subfamily


This is M-zodatoxin-Lt6a/c protein, from Spider, contains 116 amino acids, is soluble, locates in Extracellular.

Does not have antimicrobial activity against Gram-positive bacteria (A,globiformis VKM Ac-1112 (MIC>70 uM) and B,subtilis VKM B-501 (MIC>70 uM)), Gram-negative bacteria (E,coli DH5-alpha (MIC>70 uM), E,coli MH1 (MIC>70 uM) and P,aeruginosa PAO1 (MIC>70 uM)), yeast (P,pastoris GS115 (MIC>70 uM) or S,cerevisiae Y190 (MIC>70 uM)), Does not have hemolytic activity against rabbit erythrocytes, However, it causes some conductance changes in planar bilayer membranes, without membrane rupture, suggesting a cytolytic function on other biological targets, It causes paralysis, but is not lethal when injected into insect larvae

Belongs to the cationic peptide 03 (latarcin) family, 06 subfamily