Answer the following question given this paragraph: 

Proteins have different shapes and molecular weights; some proteins are globular in shape whereas others are fibrous in nature. For example, hemoglobin is a globular protein, but collagen, found in our skin, is a fibrous protein. Protein shape is critical to its function, and this shape is maintained by many different types of chemical bonds. Changes in temperature, pH, and exposure to chemicals may lead to permanent changes in the shape of the protein, leading to loss of function, known as denaturation. All proteins are made up of different arrangements of the same 20 types of amino acids.


Q: Changes in temperature, ph, and exposure to chemicals may lead to permanent changes in the shape of a protein, leading to loss of function known as what?

 Choices:

- digestion

- fermentation

- bioturbation

- denaturation

A:
denaturation
