Fact 1: Disease-causing microbes have a negative impact on the body.

Fact 2: Pathogens are microbes that cause disease.

Given the two facts above, answer the question "Pathogens do what?" with the following options: 
- Break down proteins
 - adapt to environment
 - influenza orthomyxoviruses
 - work symbiotically with humans
 - the immune response
 - cure disease
 - have a negative impact on the body
 - are harmless


 

       have a negative impact on the body  